Amino acid metabolism
Cysteine depletion induces pancreatic tumor ferroptosis in mice – Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive. https://science.sciencemag.org/content/368/6486/85
Identifying strategies to target the metabolic flexibility of tumours – Andrés Méndez-Lucas, Wei Lin, Paul C. Driscoll, Nathalie Legrave, Laura Novellasdemunt, Chencheng Xie, Mark Charles, Zena Wilson, Neil P. Jones, Stephen Rayport, Manuel Rodríguez-Justo, Vivian Li, James I. MacRae, Nissim Hay, Xin Chen and Mariia Yuneva. https://www.nature.com/articles/s42255-020-0195-8
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma – Kewen Hu, Kun Li, Jing Lv, Jie Feng, Jing Chen, Haigang Wu, Feixiong Cheng, Wenhao Jiang, Jieqiong Wang, Haixiang Pei, Paul J. Chiao, Zhenyu Cai, Yihua Chen, Mingyao Liu, and Xiufeng Pang. https://www.jci.org/articles/view/124049
Serine Catabolism Feeds NADH when Respiration Is Impaired – Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30114-5
ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase – Robert T. Williams, Rohiverth Guarecuco, Leah A. Gates, Douglas Barrows, Maria C. Passarelli, Bryce Carey, Lou Baudrier, Swarna Jeewajee, Konnor La, Benjamin Prizer, Sohail Malik, Javier Garcia-Bermudez, Xiphias Ge Zhu, Jason Cantor, Henrik Molina, Thomas Carroll, Robert G. Roeder, Omar Abdel-Wahab, C. David Allis, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30123-6
EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma – Rui Yang, Xiuxiu Li, Yanan Wu, Guanghui Zhang, Xiaoran Liu, Yanping Li, Yonghua Bao, Wancai Yang and Hongjuan Cui. https://www.nature.com/articles/s41388-020-1199-2
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival – Longfei Deng, Pengbo Yao, Le Li, Fansen Ji, Shuang Zhao, Chang Xu, Xun Lan and Peng Jiang. https://www.nature.com/articles/s41467-020-15573-6
Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers – Suman Mukhopadhyay, Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin, Serguei V. Kozlov, Dwight V. Nissley and Frank McCormick. https://cancerres.aacrjournals.org/content/80/8/1630
Interaction of the neutral amino acid transporter ASCT2 with basic amino acids – Elias Ndaru, Rachel-Ann A. Garibsingh, Laura Zielewicz, Avner Schlessinger, Christof Grewer. https://portlandpress.com/biochemj/article/477/8/1443/222575/Interaction-of-the-neutral-amino-acid-transporter
Glucose metabolism
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer – Hunain Alam, Ming Tang, Mayinuer Maitituoheti, Shilpa S. Dhar, Manish Kumar, Chae Young Han, Chandrashekar R. Ambati, Samir B. Amin, Bingnan Gu, Tsai-Yu Chen, Yu-Hsi Lin, Jichao Chen, Florian L. Muller, Nagireddy Putluri, Elsa R. Flores, Francesco J. DeMayo, Laura Baseler, Kunal Rai, Min Gyu Lee. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30106-9
Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3) – D. A. Richardson, P. Sritangos, A. D. James, A. Sultan and J. I. E. Bruce. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0210-2
Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis – Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang and Chunlin Shao. https://link-springer-com.sire.ub.edu/article/10.1007/s11010-020-03729-3
Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition – Aaminah Khan, Emanuele Valli, Hayley Lam, David A. Scott, Jayne Murray, Kimberley M. Hanssen, Georgina Eden, Laura D. Gamble, Rupinder Pandher, Claudia L. Flemming, Sophie Allan, Andrei L. Osterman, Michelle Haber, Murray D. Norris, Jamie I. Fletcher and Denise M. T. Yu. https://www.nature.com/articles/s41388-020-1235-2
Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth – Simranjot Bawa, David S Brooks, Kathryn E Neville, Marla Tipping, Md Abdul Sagar, Joseph A Kollhoff, Geetanjali Chawla, Brian V Geisbrecht, Jason M Tennessen, Kevin W Eliceiri, Erika R Geisbrecht. https://elifesciences.org/articles/52358
Lipid metabolism
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis – Daqian Xu, Zheng Wang, Yan Xia, Fei Shao, Weiya Xia, Yongkun Wei, Xinjian Li, Xu Qian, Jong-Ho Lee, Linyong Du, Yanhua Zheng, Guishuai Lv, Jia-shiun Leu, Hongyang Wang, Dongming Xing, Tingbo Liang, Mien-Chie Hung and Zhimin Lu. https://www.nature.com/articles/s41586-020-2183-2
Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer – Daniela Criscuolo, Rosario Avolio, Giovanni Calice, Chiara Laezza, Simona Paladino, Giovanna Navarra, Francesca Maddalena, Fabiana Crispo, Cristina Pagano, Maurizio Bifulco, Matteo Landriscina, Danilo Swann Matassa, Franca Esposito. https://www.mdpi.com/2073-4409/9/4/828
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling – Divya Venkatesh, Nicholas A. O’Brien, Fereshteh Zandkarimi, David R. Tong, Michael E. Stokes, Denise E. Dunn, Everett S. Kengmana, Allegra T. Aron, Alyssa M. Klein, Joleen M. Csuka, Sung-Hwan Moon, Marcus Conrad, Christopher J. Chang, Donald C. Lo, Angelo D’Alessandro, Carol Prives and Brent R. Stockwell. http://genesdev.cshlp.org/content/34/7-8/526.abstract?etoc
Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance – Abir Mukherjee, Chun-Yi Chiang, Helen A. Daifotis, Kristin M. Nieman, Johannes F. Fahrmann, Ricardo R. Lastra, Iris L. Romero, Oliver Fiehn and Ernst Lengyel. https://cancerres.aacrjournals.org/content/80/8/1748
Nucleotides
IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex – Alexander J. Valvezan, Molly C. McNamara, Spencer K. Miller, Margaret E. Torrence, John M. Asara, Elizabeth P. Henske, and Brendan D. Manning. https://insight.jci.org/articles/view/135071
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells – Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic. https://science.sciencemag.org/content/368/6488/283
Mitochondria
IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism – Atsuhito Tsuji, Takumi Akao, Takahiro Masuya, Masatoshi Murai and Hideto Miyoshi. http://www.jbc.org/content/early/2020/04/14/jbc.RA120.013366.abstract
High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung – Mitchell Frederick, Heath D. Skinner, Sawad A. Kazi, Andrew G. Sikora and Vlad C. Sandulache. https://www.nature.com/articles/s41598-020-63448-z
Starvation
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells – Franziska Püschel, Francesca Favaro, Jaime Redondo-Pedraza, Estefanía Lucendo, Raffaella Iurlaro, Sandrine Marchetti, Blanca Majem, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Eric Chevet, and Cristina Muñoz-Pinedo. https://www.pnas.org/content/early/2020/04/17/1913707117/
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer – Xiaoguang Liu, Kellen Olszewski, Yilei Zhang, Esther W. Lim, Jiejun Shi, Xiaoshan Zhang, Jie Zhang, Hyemin Lee, Pranavi Koppula, Guang Lei, Li Zhuang, M. James You, Bingliang Fang, Wei Li, Christian M. Metallo, Masha V. Poyurovsky and Boyi Gan. https://www.nature.com/articles/s41556-020-0496-x
High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11) – Itsuki Yamaguchi, Shige H. Yoshimura and Hironori Katoh. http://www.jbc.org/content/early/2020/04/07/jbc.RA119.012213.abstract
Reorganization of budding yeast cytoplasm upon energy depletion – Guendalina Marinia, Elisabeth Nüskea, Weihua Lenga, Simon Albertia, and Gaia Pigino. https://www.molbiolcell.org/doi/10.1091/mbc.E20-02-0125?ai=25zg&ui=2oy6&af=T
Nutrient sensing/mTOR
Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity – Neeharika Nemani , Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, Karthik Ramachandran, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya SinghMalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Christopher E. Shannon, Warren G. Tourtellotte, Brij B. Singh, W. Brian Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Jonathan Soboloff, Muniswamy Madesh. https://stke.sciencemag.org/content/13/628/eaaz6206
Mitochondrial localization of SESN2 – Irina E Kovaleva, Artem V Tokarchuk, Andrei O Zheltukhin, Alexandra A Dalina, Grigoriy G Safronov, Alexandra G Evstafieva, Konstantin G Lyamzaev, Peter M Chumakov, Andrei V Budanov. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226862
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells – Yeonjin Kim, Mark S. Sundrud, Changqian Zhou, Maja Edenius, Davide Zocco, Kristen Powers, Miao Zhang, Ralph Mazitschek, Anjana Rao, Chang-Yeol Yeo, Erika H. Noss, Michael B. Brenner, Malcolm Whitman, and Tracy L. Keller. https://www.pnas.org/content/117/16/8900.abstract?etoc
The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4 – Thomas D Burton, Anthony O Fedele, Jianling Xie, Lauren Sandeman and Christopher G. Proud. http://www.jbc.org/content/early/2020/04/20/jbc.RA119.011864.abstract
Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver – Cédric Gobet, Benjamin Dieter Weger, Julien Marquis, Eva Martin, Nagammal Neelagandan, Frédéric Gachon, and Felix Naef. https://www.pnas.org/content/117/17/9630.abstract?etoc
Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress in Saccharomyces cerevisiae – Imadeddin Hijazi, Jeffrey Knupp and Amy Chang. http://jcs.biologists.org/content/133/6/jcs241539?etoc
A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth – Chase H. Melick, Delong Meng and Jenna L. Jewell. http://www.jbc.org/content/early/2020/04/20/jbc.AC120.012595.abstract
Hypoxia
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism – Isha H. Jain, Sarah E. Calvo, Andrew L. Markhard, Owen S. Skinner, Tsz-Leung To, Tslil Ast, Vamsi K. Mootha. https://www.cell.com/cell/fulltext/S0092-8674(20)30321-4
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia – Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates III, Sua Myong, John K Kim. https://elifesciences.org/articles/48480
HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α – Peizhan Chen, Xiaohua Duan, Xiaoguang Li, Jingquan Li, Qian Ba and Hui Wang. https://www.nature.com/articles/s41388-020-1190-y
Cancer Immunometabolism
Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages – Pan Su, Qiang Wang, Enguang Bi, Xingzhe Ma, Lintao Liu, Maojie Yang, Jianfei Qian and Qing Yi. https://cancerres.aacrjournals.org/content/80/7/1438
Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy – Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo. https://elifesciences.org/articles/52330
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment – Prasenjit Dey, Jun Li, Jianhua Zhang, Surendra Chaurasiya, Anders Strom, Huamin Wang, Wen-Ting Liao, Frederick Cavallaro, Parker Denz, Vincent Bernard, Er-Yen Yen, Giannicola Genovese, Pat Gulhati, Jielin Liu, Deepavali Chakravarti, Pingna Deng, Tingxin Zhang, Federica Carbone, Qing Chang, Haoqiang Ying, Xiaoying Shang, Denise J. Spring, Bidyut Ghosh, Nagireddy Putluri, Anirban Maitra, Y. Alan Wang and Ronald A. DePinho. https://cancerdiscovery.aacrjournals.org/content/10/4/608
IDH
Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2 – Ritika Dutta, Tian Yi Zhang, Thomas Köhnke, Daniel Thomas, Miles Linde, Eric Gars, Melissa Stafford, Satinder Kaur, Yusuke Nakauchi, Raymond Yin, Armon Azizi, Anupama Narla, and Ravindra Majeti. https://www.jci.org/articles/view/133344
Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas – Yuxiang Wang , Aaron T. Wild, Sevin Turcan, Wei H. Wu, Carlie Sigel, David S. Klimstra, Xiaoxiao Ma, Yongxing Gong, Eric C. Holland, Jason T. Huse, Timothy A. Chan. https://advances.sciencemag.org/content/6/17/eaaz3221
Miscellaneous
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis – Katerina Rohlenova, Jermaine Goveia, Melissa García-Caballero, Abhishek Subramanian, Joanna Kalucka, Lucas Treps, Kim D. Falkenberg, Laura P.M.H. de Rooij, Yingfeng Zheng, Lin Lin, Liliana Sokol, Laure-Anne Teuwen, Vincent Geldhof, Federico Taverna, Andreas Pircher, Lena-Christin Conradi, Shawez Khan, Steve Stegen, Dena Panovska, Frederik De Smet, Frank J.T. Staal, Rene J. Mclaughlin, Stefan Vinckier, Tine Van Bergen, Nadine Ectors, Patrik De Haes, Jian Wang, Lars Bolund, Luc Schoonjans, Tobias K. Karakach, Huanming Yang, Geert Carmeliet, Yizhi Liu, Bernard Thienpont, Mieke Dewerchin, Guy Eelen, Xuri Li, Yonglun Luo, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30124-8
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress – Hakjoo Lee, Sylvia B. Smith, Shey-Shing Sheu and Yisang Yoon. https://www.jbc.org/content/early/2020/04/03/jbc.RA119.010983.abstract
Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor – Yejun Zou, Aoxue Wang, Li Huang, Xudong Zhu, Qingxun Hu, Yinan Zhang, Xianjun Chen, Fengwen Li, Qiaohui Wang, Hu Wang, Renmei Liu, Fangting Zuo, Ting Li, Jing Yao, Yajie Qian, Mei Shi, Xiao Yue, Weicai Chen, Zhuo Zhang, Congrong Wang, Yong Zhou, Linyong Zhu, Zhenyu Ju, Joseph Loscalzo, Yi Yang, Yuzheng Zhao. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30144-1
Metabolic Imaging Using Hyperpolarized Pyruvate–Lactate Exchange Assesses Response or Resistance to the EGFR Inhibitor Cetuximab in Patient-Derived HNSCC Xenografts – Lionel Mignion, Stefania Acciardo, Florian Gourgue, Nicolas Joudiou, Xavier Caignet, Rose-Marie Goebbels, Cyril Corbet, Olivier Feron, Caroline Bouzin, Patrice D. Cani, Jean-Pascal Machiels, Sandra Schmitz and Bénédicte F. Jordan. https://clincancerres.aacrjournals.org/content/26/8/1932
AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture – Dongqing Zheng, Jonathan H. Sussman, Matthew P. Jeon, Sydney T. Parrish, Melanie A. MacMullan, Alireza Delfarah and Nicholas A. Graham. http://jcs.biologists.org/content/133/7/jcs239277?etoc
GAPDH Delivers Heme to Soluble Guanylyl Cyclase – Yue Dai, Elizabeth A. Sweeny, Simon Schlanger, Arnab Ghosh and Dennis J. Stuehr. http://www.jbc.org/content/early/2020/04/30/jbc.RA120.013802.abstract
Reviews
Metabolic reprogramming and cancer progression – Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis. https://science.sciencemag.org/content/368/6487/eaaw5473
Nitrogen Metabolism in Cancer and Immunity – Kiran Kurmi, Marcia C. Haigis. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30040-4
Metabolic Reprogramming in Tumors: Contributions of the Tumor Microenvironment – Andrew N Lane, Richard M Higashi, Teresa W-M Fan. https://www.sciencedirect.com/science/article/pii/S2352304219300947?via%3Dihub
Enzyme promiscuity, metabolite damage, and metabolite damage control systems of the tricarboxylic acid cycle – Thomas D. Niehaus, Katie B. Hillmann. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15284
The integrated stress response: From mechanism to disease – Mauro Costa-Mattioli, Peter Walter. https://science.sciencemag.org/content/368/6489/eaat5314
A non-proliferative role of pyrimidine metabolism in cancer – Aarif Siddiqui, Paolo Ceppi. https://www.sciencedirect.com/science/article/pii/S221287782030034X?dgcid=raven_sd_via_email
On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity – Shobbir Hussain. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30069-8
Seminars in Cell & Developmental Biology special issue: Cancer Cells & Therapeutic Targets – Edited by Massimo Donadelli, Chiara Riganti. https://www.sciencedirect.com/journal/seminars-in-cell-and-developmental-biology/vol/98/suppl/C
Including:
Mitochondrial metabolic alterations in cancer cells and related therapeutic targets
Chiara Riganti, Massimo Donadelli
Regulation of succinate dehydrogenase and role of succinate in cancer
Elisa Dalla Pozza, Ilaria Dando, Raffaella Pacchiana, Elio Liboi, … Marta Palmieri
Fumarate hydratase in cancer: A multifaceted tumour suppressor
Christina Schmidt, Marco Sciacovelli, Christian Frezza
The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?
Houda Abla, Manuela Sollazzo, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Porcelli
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
José M. Matés, Floriana J. Di Paola, José A. Campos-Sandoval, Sybille Mazurek, Javier Márquez
Role of coenzymes in cancer metabolism
Maheshwor Thapa, Guido Dallmann
Exploiting metabolic vulnerabilities of Non small cell lung carcinoma
Blanca Majem, Ernest Nadal, Cristina Muñoz-Pinedo
Metabolic pathways regulating colorectal cancer initiation and progression
Sofia La Vecchia, Carlos Sebastián
Marina Bacci, Luigi Ippolito, Lucia Magnelli, Elisa Giannoni, Paola Chiarugi
Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?
Joanna Kopecka, Elena Gazzano, Barbara Castella, Iris C. Salaroglio, … Chiara Riganti
The multifaceted effects of metformin on tumor microenvironment
Ivana Kurelac, Nikkitha Umesh Ganesh, Maria Iorio, Anna Maria Porcelli, Giuseppe Gasparre
3D gastrointestinal models and organoids to study metabolism in human colon cancer
Catarina Silva-Almeida, Marie-Ann Ewart, Colin Wilde
Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer diseas
Giovanni Blandino, Fabio Valenti, Andrea Sacconi, Silvia Di Agostino
NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond
Daria Capece, Daniela Verzella, Barbara Di Francesco, Edoardo Alesse, … Francesca Zazzeroni
Autophagy and mitophagy in cancer metabolic remodelling
Fabio Ferro, Stéphane Servais, Pierre Besson, Sébastien Roger, … Lucie Brisson
Mitochondria as playmakers of apoptosis, autophagy and senescence
Marianna Abate, Agostino Festa, Michela Falco, Angela Lombardi, … Gabriella Misso
Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer
Saharnaz Sarlak, Claude Lalou, Nivea Dias Amoedo, Rodrigue Rossignol
Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective
Alessandro Rimessi, Gaia Pedriali, Bianca Vezzani, Anna Tarocco, … Paolo Pinton
Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines
Tânia Capelôa, Zohra Benyahia, Luca X. Zampieri, Marine C.N.M. Blackman, Pierre Sonveaux
Valentina Audrito, Antonella Managò, Federica Gaudino, Silvia Deaglio
Catherine Vander Linden, Cyril Corbet
From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer
Sepideh Aminzadeh-Gohari, Daniela D. Weber, Silvia Vidali, Luca Catalano, … René G. Feichtinger
Comments
NADH Ties One-Carbon Metabolism to Cellular Respiration – Adam G. Maynard, Naama Kanarek. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30127-3
Why Warburg Works: Lactate Controls Immune Evasion through GPR81 – Kathrine Lundø, Mette Trauelsen, Stine F. Pedersen, Thue W. Schwartz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30116-9
FABP4: A New Player in Obesity-Associated Breast Cancer – Jun Zeng, Edward R. Sauter, Bing Li. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30076-9
