MetaboList – May 2020


Glucose metabolism


A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway – Jonathan M. Ghergurovich, Juan C. García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, Mari Carmen Gomez-Cabrera, Agustín Lahoz, Jing Fan, Ulf H. Beier, Hahn Kim and Joshua D. Rabinowitz. https://www.nature.com/articles/s41589-020-0533-x

N6-methyladenosine regulates glycolysis of cancer cells through PDK4 – Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin and Hongsheng Wang. https://www.nature.com/articles/s41467-020-16306-5

Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts – Kozlov AM, Lone A, Betts DH, Cumming RC. https://www.nature.com/articles/s41598-020-65193-9

Glycolytic biomarkers predict transformation in patients with follicular lymphoma – Ida Monrad, Charlotte Madsen, Kristina Lystlund Lauridsen, Bent Honoré, Trine Lindhardt Plesner, Stephen Hamilton-Dutoit, Francesco d’Amore, Maja Ludvigsen. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233449


Methionine, Serine, one-carbon


Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function – Henry Kurniawan, Davide G. Franchina, Luana Guerra, Lynn Bonetti, Leticia Soriano – Baguet, Melanie Grusdat, Lisa Schlicker, Oliver Hunewald, Catherine Dostert, Myriam P. Merz, Carole Binsfeld, Gordon S. Duncan, Sophie Farinelle, Yannic Nonnenmacher, Jillian Haight, Dennis Das Gupta, Anouk Ewen, Rabia Taskesen, Rashi Halder, Ying Chen, Christian Jäger, Markus Ollert, Paul Wilmes, Vasilis Vasiliou, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Jonathan D. Turner, Tak W. Mak, Michael Lohoff, Johannes Meiser, Karsten Hiller, Dirk Brenner. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30119-4

DISTINCT PATTERN OF ONE-CARBON METABOLISM, A NUTRIENT-SENSITIVE PATHWAY, IN INVASIVE BREAST CANCER: A METABOLOMIC STUDYJéssica Reis Santos, Dan Linetzky Waitzberg, Ismael Dale Cotrim Guerreiro da Silva, Tharcisio Citrangulo Tortelli Junior, Luciana Rodrigues Carvalho Barros, Gisele André Baptista Canuto, Andréa Tedesco Faccio, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Marina Franco Maggi Tavares, Ana Cristina Martinez, Ângela Flavia Logullo, Raquel Suzana M.M. Torrinhas, and Graziela Ravacci. https://www.oncotarget.com/article/27575/text/

Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity – Nairita Maitra, Chong He, Heidi M Blank, Mitsuhiro Tsuchiya, Birgit Schilling,  Matt Kaeberlein, Rodolfo Aramayo, Brian K Kennedy , Michael Polymenis. https://elifesciences.org/articles/53127 


Other amino acids / polyamines


Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress – Simon Schwörer, Mirela Berisa, Sara Violante, Weige Qin, Jiajun Zhu, Ronald C Hendrickson, Justin R Cross, Craig B Thompson. https://www.embopress.org/doi/abs/10.15252/embj.2019103334

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma – Tjaden B, Baum K, Marquardt V, Simon M, Trajkovic-Arsic M, Kouril T, Siebers B, Lisec J, Siveke JT, Schulte JH, Benary U, Remke M, Wolf J, Schramm A. https://www.nature.com/articles/s41598-020-64040-1

Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs – Akihiko Sakamoto, Yusuke Terui, Takeshi Uemura, Kazuei Igarashi and Keiko Kashiwagi. http://www.jbc.org/content/early/2020/05/06/jbc.RA120.013833.abstract

Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling – Shailer B. Martin, William S. Reiche, Nicholas A. Fifelski, Alexander J. Schultz, Spencer J. Stanford, Alexander A. Martin, Danielle L. Nack, Bernhard Radlwimmer, Michael P. Boyer, Elitsa A. Ananieva. https://portlandpress.com/biochemj/article/477/9/1579/222659/Leucine-and-branchedchain-amino-acid-metabolism

Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum – Cassandra E. Holbert, Matthew Dunworth, Jackson R. Foley, Tiffany T. Dunston, Tracy Murray Stewart and Robert A. Casero Jr. http://www.jbc.org/content/early/2020/05/19/jbc.RA120.013867.abstract


Nucleotides


Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex – Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A. https://www.jbc.org/content/early/2020/05/21/jbc.RA119.012175

SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network – Archan Chakraborty, Wei-Cheng Lin, Yu-Tsun Lin, Kuang-Jing Huang, Pei-Yu Wang, Ian Yi-Feng Chang, Hsiang-Iu Wang, Kung-Ting Ma, Chun-Yen Wang, Xuan-Rong Huang, Yen-Hsien Lee, Bi-Chang Chen, Ya-Ju Hsieh, Kun-Yi Chien, Tzu-Yang Lin, Ji-Long Liu, Li-Ying Sung, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai. https://jcs.biologists.org/content/133/9/jcs240200?etoc

Methotrexate Elicits Pro-Respiratory and Anti-Growth Effects by Promoting AMPK Signaling – David J Papadopoli, Eric H Ma, Dominic Roy, Mariana Russo, Gaëlle Bridon, Daina Avizonis, Russell G Jones, Julie St-Pierre. https://www.nature.com/articles/s41598-020-64460-z


Mitochondria


Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitorsÁlvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals. https://www.embopress.org/doi/full/10.15252/emmm.201911217

Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer – Jason R Brown, Daniel K. Chan, Jessica J Shank, Kent A. Griffith, Huihui Fan, Robert Szulawski, Kun Yang, R. Kevin Reynolds, Carolyn Johnston, Karen McLean, Shitanshu Uppal, J. Rebecca Liu, Lourdes Cabrera, Sarah E Taylor, Brian C. Orr, Francesmary Modugno, Pooja Mehta, Michael Bregenzer, Geeta Mehta, Hui Shen, Lan Coffman, and Ronald J. Buckanovich. https://insight.jci.org/articles/view/133247

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I – Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst,  Barrie Kellam, Anne E Willis. https://elifesciences.org/articles/55845

Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells – Kenta Kuramoto, Masahiro Yamamoto, Shuhei Suzuki, Tomomi Sanomachi, Keita Togashi, Shizuka Seino, Chifumi Kitanaka, Masashi Okada. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15187


Starvation / metabolic stress


Distinct Mitochondrial Defects Trigger the Integrated Stress Response Depending on the Metabolic State of the Cell – Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha. https://elifesciences.org/articles/49178

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy – David Pla‐Martín, Désirée Schatton, Janica L Wiederstein, Marie‐Charlotte Marx, Salim Khiati, Marcus Krüger, Elena I Rugarli. https://www.embopress.org/doi/full/10.15252/embj.2019102731

AKT Ser/Thr kinase increases V-ATPase–dependent lysosomal acidification in response to amino acid starvation in mammalian cells – Michael P. Collins, Laura A. Stransky and Michael Forgac. http://www.jbc.org/content/early/2020/05/14/jbc.RA120.013223.abstract


Nutrient sensing / ATF4


p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators – Charles N. Birts , Arindam Banerjee, Matthew Darley, Charles R. Dunlop, Sarah Nelson, Sharandip K. Nijjar, Rachel Parker, Jonathan West, Ali Tavassoli, Matthew J. J. Rose-Zerilli, Jeremy P. Blaydes. https://stke.sciencemag.org/content/13/630/eaau9529

Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1 – Jianyin Long, Daniel L. Galvan, Koki Mise, Yashpal S. Kanwar, Li Li, Naravat Poungvarin, Paul A. Overbeek, Benny H Chang and Farhad R. Danesh. http://www.jbc.org/content/early/2020/05/28/jbc.RA120.013228.abstract

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion – Aharon Helman, Andrew L. Cangelosi, Jeffrey C. Davis, Quan Pham, Arielle Rothman, Aubrey L. Faust, Juerg R. Straubhaar, David M. Sabatini, Douglas A. Melton. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30186-8

ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila – Sebastian Sorge, Jonas Theelke, Kerem Yildirim, Helen Hertenstein, Ellen McMullen, Stephan Müller, Christian Altbürger, Stefanie Schirmeier, Ingrid Lohmann. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30612-4


IDH


Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism – Di Yu, Yang Liu, Yiqiang Zhou, Victor Ruiz-Rodado, Mioara Larion, Guowang Xu, and Chunzhang Yang. https://www.pnas.org/content/117/18/9964.abstract?etoc


Miscellaneous


Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis [CAD is the deamidase] – Jun Zhao, Mao Tian, Shu Zhang, Alireza Delfarah, Ruoyun Gao, Youliang Rao, Ali Can Savas, Anjie Lu, Larissa Bubb, Xiao Lei, Rosa Moshirian, Wenjie Zhu, Cheng Peng, Taijiao Jiang, Lin Chen, Nicholas A. Graham, Pinghui Feng. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30188-1

Common biochemical properties of metabolic genes recurrently dysregulated in tumors – Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis and Sriram Chandrasekaran. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0211-1

N‐acetyl‐l‐tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals – Takashi Matsumura, Outa Uryu, Fumikazu Matsuhisa, Keiji Tajiri, Hitoshi Matsumoto, Yoichi Hayakawa. https://www.embopress.org/doi/abs/10.15252/embr.201949211

Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation – Accalia Fu, Juan Carlos Alvarez-Perez, Daina Avizonis, Tatsuya Kin, Scott B. Ficarro, Dong Wook Choi, Esra Karakose, Mehmet G. Badur, Lindsay Evans, Carolina Rosselot, Gaelle Bridon, Gregory H. Bird, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jurre J. Kamphorst, Andrew F. Stewart, A. M. James Shapiro, Jarrod A. Marto, Loren D. Walensky, Russell G. Jones, Adolfo Garcia-Ocana and Nika N. Danial. https://www.nature.com/articles/s42255-020-0199-4


Reviews


Advances into understanding metabolites as signaling molecules in cancer progression – Joyce Y. Liu, Kathryn E. Wellen. https://www.sciencedirect.com/science/article/abs/pii/S095506742030020X

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic CellsFernando Erra Díaz, Valeria Ochoa, Antonela Merlotti, Ezequiel Dantas, Ignacio Mazzitelli, Virginia Gonzalez Polo, Juan Sabatté, Sebastián Amigorena, Elodie Segura, Jorge Geffner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30562-3

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions – Jawed A. Siddiqui, Ramesh Pothuraju, Maneesh Jain, Surinder K.Batra, Mohd W.Nasser. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20300159

Cholesterol and beyond – The role of the mevalonate pathway in cancer biology – Andy Göbel, Martina Rauner, Lorenz C. Hofbauer, Tilman D. Rachner. https://www.sciencedirect.com/science/article/abs/pii/S0304419X1930174X

Death by lipids: the role of small nucleolar RNAs in metabolic stress – Jean E. Schaffer. http://www.jbc.org/content/early/2020/05/11/jbc.AW120.011105.abstract

The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance – Margot Riggi, Beata Kusmider and Robbie Loewith. http://jcs.biologists.org/content/133/9/jcs242040?etoc

Metabolic Flux Analysis: Moving beyond Static MetabolomicsSilvia Radenkovic, Ivan Vuckovic, Ian R. Lanza. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30059-1

Folding the Mitochondrial UPR into the Integrated Stress ResponseNadine S. Anderson, Cole M. Haynes. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30055-6

The Complex Interplay between Antioxidants and ROS in Cancer – Isaac S. Harris, Gina M. DeNicola. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30058-1

Emerging Mechanisms and Disease Relevance of Ferroptosis – Brent R. Stockwell, Xuejun Jiang, Wei Gu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30054-4

Reprogramming of serine, glycine and one-carbon metabolism in cancer – Li AM, Ye J. https://pubmed.ncbi.nlm.nih.gov/32439610/

Chromatin as a key consumer in the metabolite economy – Diehl KL, Muir TW. https://www.nature.com/articles/s41589-020-0517-x

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death – Daher B, Vučetić M, Pouysségur J. https://www.frontiersin.org/articles/10.3389/fonc.2020.00723/full


Comments


Glutamine: A bad guy for antitumor immunity? – Lewis Z. Shi. https://stm.sciencemag.org/content/12/542/eabb7093

Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers – G. Aaron Hobbs, Channing J. Der. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30055-4

A BAD portion of glucose can be good for inflamed beta cells – Christian Frezza. https://www.nature.com/articles/s42255-020-0198-5

CLUHing in mitochondria to starvation – Annalisa M. VanHook. https://stke.sciencemag.org/content/13/631/eabc6690

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