MetaboList – June 2020


Serine / glycine / one carbon


Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcomaMadi Y. Cissé , Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, Hélène Delpech, Romain Riscal, Giuseppe Arena, Frédéric Chibon, Sophie Le Gellec, Aurélie Maran-Gonzalez, Marie-Christine Chateau, Charles Theillet, Sébastien Carrere, Jean-Charles Portais, Laurent Le Cam, Laetitia K. Linares. https://stm.sciencemag.org/content/12/547/eaay2163.full

SHMT Inhibition Is Effective and Synergizes With Methotrexate in T-cell Acute Lymphoblastic LeukemiaJuan C García-Cañaveras, Olga Lancho, Gregory S Ducker, Jonathan M Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D Rabinowitz. https://pubmed.ncbi.nlm.nih.gov/32382081

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencingSara Parsa, Ana Ortega-Molina, Hsia-Yuan Ying, Man Jiang, Matt Teater, Jiahui Wang, Chunying Zhao, Ed Reznik, Joyce P. Pasion, David Kuo, Prathibha Mohan, Shenqiu Wang, Jeannie M. Camarillo, Paul M. Thomas, Neeraj Jain, Javier Garcia-Bermudez, Byoung-kyu Cho, Wayne Tam, Neil L. Kelleher, Nicholas Socci, Ahmet Dogan, Elisa De Stanchina, Giovanni Ciriello, Michael R. Green, Sheng Li, Kivanc Birsoy, Ari M. Melnick and Hans-Guido Wendel. https://www.nature.com/articles/s43018-020-0080-0

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progressionJuan Liu, Cen Zhang, Hao Wu, Xiao-Xin Sun, Yanchen Li, Shan Huang, Xuetian Yue, Shou-En Lu, Zhiyuan Shen, Xiaoyang Su, Eileen White, Bruce G. Haffty, Wenwei Hu, and Zhaohui Feng. https://www.jci.org/articles/view/132876


Other amino acids


Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic CancerSeth J. Parker, Caroline R. Amendola, Kate E.R. Hollinshead, Qijia Yu, Keisuke Yamamoto, Joel Encarnación-Rosado, Rebecca E. Rose, Madeleine M. LaRue, Albert S.W. Sohn, Doug E. Biancur, Joao A. Paulo, Steven P. Gygi, Drew R. Jones, Huamin Wang, Mark R. Philips, Dafna Bar-Sagi, Joseph D. Mancias and Alec C. Kimmelman. https://cancerdiscovery.aacrjournals.org/content/10/7/1018

Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cellsAimin Cai, Hailun Zheng, Zhiwei Chen, Xinlu Lin, Chen Li, Qing yao, Yangzom D. Bhutia, Vadivel Ganapathy, Ruijie Chen, Longfa Kou. https://portlandpress.com/biochemj/article/477/10/1923/223853

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrenceChao-Chieh Lin, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, Jeremy Force, Jeffrey R. Marks, Tso-Pang Yao, James V. Alvarez and Jen-Tsan Chi. https://www.nature.com/articles/s41418-020-0499-y


Glucose metabolism


Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast CancerLisa M. Becker, Joyce T. O’Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu, Raghu Kalluri. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30671-9

PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancerDanna Yeerken, Ruoxi Hong, Yan Wang, Ying Gong, Rui Liu, Di Yang, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang, Qimin Zhan. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233750

Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor MicroenvironmentPei-pei Hou, Li-juan Luo, Hang-zi Chen, Qi-tao Chen, Xue-li Bian, Sheng-fu Wu, Jia-xin Zhou, Wen-xiu Zhao, Jian-ming Liu, Xiao-min Wang, Zhi-yuan Zhang, Lu-ming Yao, Qinghua Chen, Dawang Zhou, Qiao Wu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30305-1

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblastsAkiko Kogure, Yutaka Naito, Yusuke Yamamoto, Masakazu Yashiro, Tohru Kiyono, Kazuyoshi Yanagihara, Kosei Hirakawa, Takahiro Ochiya. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234613

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen and Ning Zhang. https://www.nature.com/articles/s41467-020-16966-3

Label-free sensing of exosomal MCT1 and CD147  for tracking metabolic reprogramming and  malignant progression in gliomaA. Thakur , G. Qiu, C. Xu, X. Han, T. Yang, S. P. NG, K. W. Y. Chan, C. M. L. Wu, Y. Lee. https://advances.sciencemag.org/content/6/26/eaaz6119


Lipid metabolism


REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumorsShuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke,  Krushna Chandra Patra, Elma Zaganjor, Kenneth Ross, Yusuke Mizukami,  Sarah Jeanfavre, Athena Chen, Mari Mino-Kenudson, Sridhar Ramaswamy,  Clary Clish, Marcia Haigis, Nabeel Bardeesy and Leif W. Ellisen. http://genesdev.cshlp.org/content/34/11-12/751.abstract?etoc

PHGDH supports liver ceramide synthesis and sustains lipid homeostasisYun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth and Gina M. DeNicola. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00212-x

Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolismErol C. Bayraktar, Konnor La, Kara Karpman, Gokhan Unlu, Ceren Ozerdem, Dylan J. Ritter, Hanan Alwaseem, Henrik Molina, Hans-Heinrich Hoffmann, Alec Millner, G. Ekin Atilla-Gokcumen, Eric R. Gamazon, Amy R. Rushing, Ela W. Knapik, Sumanta Basu and Kıvanç Birsoy. https://www.nature.com/articles/s42255-020-0206-9

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolismMichael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone and Jason Moffat. https://www.nature.com/articles/s42255-020-0211-z

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancerKaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson and Martin C. Sadowski. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00217-6

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived EicosanoidsNikos Koundouros, Evdoxia Karali, Aurelien Tripp, Adamo Valle, Paolo Inglese, Nicholas J.S. Perry, David J. Magee, Sara Anjomani Virmouni, George A. Elder, Adam L. Tyson, Maria Luisa Dória, Antoinette van Weverwijk, Renata F. Soares, Clare M. Isacke, Jeremy K. Nicholson, Robert C. Glen, Zoltan Takats, George Poulogiannis. https://www.cell.com/cell/fulltext/S0092-8674(20)30686-3


Nucleotides


ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine SynthesisEunus S. Ali, Umakant Sahu, Elodie Villa, Brendan P. O’Hara, Peng Gao, Cynthia Beaudet, Antony W. Wood, John M. Asara, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30302-6

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxiaKarolina Losenkova, Mariachiara Zuccarini, Marika Karikoski, Juha Laurila, Detlev Boison, Sirpa Jalkanen and Gennady G. Yegutkin. http://jcs.biologists.org/content/133/10/jcs241463?etoc


Mitochondria


Defective NADPH production in mitochondrial disease complex I causes inflammation and cell deathEduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench and Pere Puigserver. https://www.nature.com/articles/s41467-020-16423-1

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growthŽiva Frangež, Yuniel Fernández-Marrero, Darko Stojkov, S. Morteza Seyed Jafari, Robert E. Hunger, Valentin Djonov, Carsten Riether and Hans-Uwe Simon. https://www.nature.com/articles/s41388-020-1339-8

Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal TumorHuang WK, Gao J, Chen Z, Shi H, Yuan J, Cui HL, Yeh CN, Bränström R, Larsson C, Li S, Lui WO. https://www.mdpi.com/2073-4409/9/6/1333

ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK InhibitionWeinan Guo, Jinyuan Ma, Yuqi Yang, Sen Guo, Weigang Zhang, Tao Zhao, Xiuli Yi, Huina Wang, Shiyu Wang, Yu Liu, Wei Dai, Xuguang Chen, Qiong Shi, Gang Wang, Tianwen Gao and Chunying Li. https://clincancerres.aacrjournals.org/content/26/11/2725


Nutrient sensing / starvation


H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell DeathYilei Zhang, Jiejun Shi, Xiaoguang Liu, Zhenna Xiao, Guang Lei, Hyemin Lee, Pranavi Koppula, Weijie Cheng, Chao Mao, Li Zhuang, Li Ma, Wei Li and Boyi Gan. https://cancerres.aacrjournals.org/content/80/11/2243

Leucine regulates autophagy via acetylation of the mTORC1 component raptorSung Min Son, So Jung Park, Eleanna Stamatakou, Mariella Vicinanza, Fiona M. Menzies and David C. Rubinsztein. https://www.nature.com/articles/s41467-020-16886-2

Metabolic energy sensing by mammalian CLC anion/proton exchangersMatthias Grieschat, Raul E Guzman, Katharina Langschwager, Christoph Fahlke, Alexi K Alekov. https://www.embopress.org/doi/full/10.15252/embr.201947872?campaign=woletoc

The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERKQin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15144?campaign=woletoc

Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylationCarlo Yague-Sanz, Yann Vanrobaeys, Ronan Fernandez, Maxime Duval, Marc Larochelle, Jude Beaudoin, Julien Berro, Simon Labbé, Pierre-Étienne Jacques and François Bachand. http://genesdev.cshlp.org/content/34/13-14/883.abstract?etoc


mTOR / AMPK


Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitorsChase H. Melick, Jenna L. Jewell. https://portlandpress.com/biochemj/article/477/10/1847/222875

Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic MutationsPatrick Hansmann, Anne Brückner, Stephan Kiontke, Bianca Berkenfeld, Guiscard Seebohm, Pascal Brouillard, Miikka Vikkula, Floor E. Jansen, Mark Nellist, Andrea Oeckinghaus, Daniel Kümmel. https://www.cell.com/structure/fulltext/S0969-2126(20)30177-5

FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restrictionAvantika Gupta, Hugo Stocker. https://elifesciences.org/articles/53159

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancerArcadi Cipponi, David L. Goode, Justin Bedo, Mark J. McCabe, Marina Pajic, David R. Croucher, Alvaro Gonzalez Rajal, Simon R. Junankar, Darren N. Saunders, Pavel Lobachevsky, Anthony T. Papenfuss, Danielle Nessem, Max Nobis, Sean C. Warren, Paul Timpson, Mark Cowley, Ana C. Vargas, Min R. Qiu, Daniele G. Generali, Shivakumar Keerthikumar, Uyen Nguyen, Niall M. Corcoran, Georgina V. Long, Jean-Yves Blay, David M. Thomas. https://science.sciencemag.org/content/368/6495/1127

AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1Eri Matsumoto, Kaho Akiyama, Takuya Saito, Yu Matsumoto, Ken-Ichi Kobayashi, Jun Inoue, Yuji Yamamoto, Tsukasa Suzuki. https://portlandpress.com/biochemj/article/477/12/2237/225005


Diet and cancer


Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trialStefanie de Groot, Rieneke T. Lugtenberg, Danielle Cohen, Marij J. P. Welters, Ilina Ehsan, Maaike P. G. Vreeswijk, Vincent T. H. B. M. Smit, Hiltje de Graaf, Joan B. Heijns, Johanneke E. A. Portielje, Agnes J. van de Wouw, Alex L. T. Imholz, Lonneke W. Kessels, Suzan Vrijaldenhoven, Arnold Baars, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Valter D. Longo, Hanno Pijl, Judith R. Kroep & Dutch Breast Cancer Research Group (BOOG). https://www.nature.com/articles/s41467-020-16138-3

Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor MacrophagesLianliang Liu, Rong Jin, Jiaqing Hao, Jun Zeng, Di Yin, Yanmei Yi, Mingming Zhu, Anita Mandal, Yuan Hua, Chin K. Ng, Nejat K. Egilmez, Edward R. Sauter and Bing Li. https://cancerres.aacrjournals.org/content/80/12/2564

A Randomized Controlled Trial of a 6-Month Low-Carbohydrate Intervention on Disease Progression in Men with Recurrent Prostate Cancer: Carbohydrate and Prostate Study 2 (CAPS2)Stephen J. Freedland, Jenifer Allen, Aubrey Jarman, Taofik Oyekunle, Andrew J. Armstrong, Judd W. Moul, Howard M. Sandler, Edwin Posadas, Dana Levin, Emily Wiggins, Lauren E. Howard, Yuan Wu and Pao-Hwa Lin. https://clincancerres.aacrjournals.org/content/26/12/3035


Biguanides / Antifolates


GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-PhosphateJianjiang Xie, Jianheng Ye, Zhiduan Cai, Yong Luo, Xuejin Zhu, Yulin Deng, Yuanfa Feng, Yingke Liang, Ren Liu, Zhaodong Han, Yuxiang Liang, Yu Zheng, Rujun Mo, Yangjia Zhuo, Yongding Wu, Funeng Jiang, Jianguo Zhu, Chin-Lee Wu and Weide Zhong. https://cancerres.aacrjournals.org/content/80/11/2150 

Repression of LKB1 by miR-1792 Sensitizes MYC-Dependent Lymphoma to Biguanide TreatmentIzreig S, Gariepy A, Kaymak I, Bridges HR, Donayo AO, Bridon G, DeCamp LM, Kitchen-Goosen SM, Avizonis D, Sheldon RD, Laister RC, Minden MD, Johnson NA, Duchaine TF, Rudoltz MS, Yoo S, Pollak MN, Williams KS, Jones RG. https://pubmed.ncbi.nlm.nih.gov/32478334/

Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma–Derived CellsYasuo Takashima, Azusa Hayano and Ryuya Yamanaka. https://clincancerres.aacrjournals.org/content/26/11/2754


Methods


Using arterial–venous analysis to characterize cancer metabolic consumption in patientsNanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G. Zacharias, Hong Lin, Hieu S. Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J. DeBerardinis, Hao Xu and Woo-ping Ge. https://www.nature.com/articles/s41467-020-16810-8

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal AdenocarcinomaKazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Shun Kishimoto, Nobu Oshima, Rajani Choudhuri, Stephen S. Adler, Elaine M. Jagoda, Keita Saito, Nallathamby Devasahayam, Peter L. Choyke, James B. Mitchell and Murali C. Krishna. https://cancerres.aacrjournals.org/content/80/11/2087

Comparative assessment of purified saponins as permeabilization agents during respirometryCorinna Dawid, Daniela Weber, Eva Musiol, Vanessa Janas, Sebastian Baur, Roman Lang, Tobias Fromme. https://www.sciencedirect.com/science/article/abs/pii/S0005272820301018


Cancer Immunometabolism


Inosine is an alternative carbon source for CD8+-T-cell function under glucose restrictionTingting Wang, J. N. Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Hayley Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Penghui Lin, Zayda Lizbeth Piedra-Quintero, Mireia Guerau-de-Arellano, Kevin A. Cassady, Song Guo Zheng, Jun Yang, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan and Ruoning Wang. https://www.nature.com/articles/s42255-020-0219-4


Miscellaneous


T cells with dysfunctional mitochondria induce multimorbidity and premature senescenceGabriela Desdín-Micó, Gonzalo Soto-Heredero, Juan Francisco Aranda, Jorge Oller, Elisa Carrasco, Enrique Gabandé-Rodríguez, Eva Maria Blanco, Arantzazu Alfranca, Lorena Cussó, Manuel Desco, Borja Ibañez, Arancha R. Gortazar, Pablo Fernández-Marcos, Maria N. Navarro, Bruno Hernaez, Antonio Alcamí, Francesc Baixauli, María Mittelbrunn. https://science.sciencemag.org/content/368/6497/1371

Intracellular pH controls WNT downstream of glycolysis in amniote embryosMasayuki Oginuma, Yukiko Harima, Oscar A. Tarazona, Margarete Diaz-Cuadros, Arthur Michaut, Tohru Ishitani, Fengzhu Xiong and Olivier Pourquié. https://www.nature.com/articles/s41586-020-2428-0

Oncometabolites suppress DNA repair by disrupting local chromatin signallingParker L. Sulkowski, Sebastian Oeck, Jonathan Dow, Nicholas G. Economos, Lily Mirfakhraie, Yanfeng Liu, Katelyn Noronha, Xun Bao, Jing Li, Brian M. Shuch, Megan C. King, Ranjit S. Bindra and Peter M. Glazer. https://www.nature.com/articles/s41586-020-2363-0

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1Rodrigo Romero, Francisco J. Sánchez-Rivera, Peter M. K. Westcott, Kim L. Mercer, Arjun Bhutkar, Alexander Muir, Tania J. González Robles, Swanny Lamboy Rodríguez, Laura Z. Liao, Sheng Rong Ng, Leanne Li, Caterina I. Colón, Santiago Naranjo, Mary Clare Beytagh, Caroline A. Lewis, Peggy P. Hsu, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks. https://www.nature.com/articles/s43018-020-0071-1

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolismHo JJD, Balukoff NC, Theodoridis PR, Wang M, Krieger JR, Schatz JH, Lee S. https://pubmed.ncbi.nlm.nih.gov/32472050/


Reviews


The Molecular Link from Diet to Cancer Cell MetabolismShree Bose, Annamarie E. Allen, Jason W. Locasale. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30319-1

Dietary Approaches to Cancer TherapyMylène Tajan, Karen H. Vousden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30204-X

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer ImmunotherapyJackie E. Bader, Kelsey Voss, Jeffrey C. Rathmell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30355-5

Drilling for Oil: Tumor-Surrounding Adipocytes Fueling CancerCamille Attané, Catherine Muller. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30084-4

Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolismBouthelier A, Aragonés J. https://www.sciencedirect.com/science/article/abs/pii/S0167488920300914

Systemic effects of mitochondrial stressRaz BarZiv, Theodore Bolas, Andrew Dillin. https://www.embopress.org/doi/abs/10.15252/embr.202050094?campaign=woletoc

You are what you eat – How nutrition and metabolism shape the genome through epigeneticsTill Bartke, Robert Schneider. https://www.sciencedirect.com/science/article/pii/S2212877820300612

Compartmentalised acyl-CoA metabolism and roles in chromatin regulationSophie Trefely, Claudia D. Lovell, Nathaniel W. Snyder, Kathryn E. Wellen. https://www.sciencedirect.com/science/article/pii/S2212877820300077

The taming of PARP1 and its impact on NAD+ metabolismSarah Hurtado-Bagès, Gunnar Knobloch, Andreas G. Ladurner, Marcus Buschbeck. https://www.sciencedirect.com/science/article/pii/S2212877820300223

Metabolic Escape Routes of Cancer Stem Cells and Therapeutic OpportunitiesTurdo A, Porcelli G, D’Accardo C, Franco SD, Verona F, Forte S, Giuffrida D, Memeo L, Todaro M, Stassi G. https://www.mdpi.com/2072-6694/12/6/1436

Role of amino acids in regulation of ROS balance in cancerJaune-Pons E, Vasseur S. https://www.sciencedirect.com/science/article/abs/pii/S0003986120304471?via%3Dihub

Chromatin-remodeling links metabolic signaling to gene expressionAshby J.Morrison. https://www.sciencedirect.com/science/article/pii/S2212877820300466

Metabolic Regulation of Tissue Stem CellsSuzanne N. Shapira, Heather R. Christofk. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30075-1

Cytokine-like Roles for Metabolites in ImmunityZbigniew Zasłona, Luke A.J. O’Neill. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30228-8 


Comments


Extracellular serine feeds cancer skin stem cellsKim Baumann. https://www.nature.com/articles/s41580-020-0261-9

Tumour metabolites hinder DNA repairLei-Lei Chen, Yue Xiong. https://www.nature.com/articles/d41586-020-01569-1

Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancerW. Brian Dalton. https://www.jci.org/articles/view/137411

Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer – https://cancerdiscovery.aacrjournals.org/content/10/6/757.1

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