MetaboList – July 2020


Glucose sensing and metabolism


Dihydroxyacetone phosphate signals glucose availability to mTORC1 – Jose M. Orozco, Patrycja A. Krawczyk, Sonia M. Scaria, Andrew L. Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini. https://www.nature.com/articles/s42255-020-0250-5

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancerMaría Gutiérrez-Salmerón, José Manuel García-Martínez, Javier Martínez-Useros, María Jesús Fernández-Aceñero, Benoit Viollet, Severine Olivier, Jagat Chauhan, Silvia R. Lucena, Antonio De la Vieja, Colin R. Goding, Ana Chocarro-Calvo, Custodia García-Jiménez. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000732

Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways – Min Li, Xuxiao He, Weixing Guo, Hongming Yu, Shicheng Zhang, Ningning Wang, Guijun Liu, Rina Sa, Xia Shen, Yabo Jiang, Yufu Tang, Yujuan Zhuo, Chunzhao Yin, Qiaochu Tu, Nan Li, Xiaoqun Nie, Yu Li, Zhimin Hu, Hanwen Zhu, Jianping Ding, Zi Li, Te Liu, Fan Zhang, He Zhou, Shengxian Li, Jiang Yue, Zheng Yan, Shuqun Cheng, Yongzhen Tao and Huiyong Yin. https://www.nature.com/articles/s43018-020-0086-7

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells – M. Caillot, J. Bourgeais, H. Dakik, É. Costé, N. M. Mazure, É. Lelièvre, O. Coqueret, O. Hérault, F. Mazurier and B. Sola. https://www.nature.com/articles/s41389-020-00253-3


Amino acid metabolism


Extracellular serine controls epidermal stem cell fate and tumour initiation – Sanjeethan C. Baksh, Pavlina K. Todorova, Shiri Gur-Cohen, Brian Hurwitz, Yejing Ge, Jesse S. S. Novak, Matthew T. Tierney, June dela Cruz-Racelis, Elaine Fuchs and Lydia W. S. Finley. https://www.nature.com/articles/s41556-020-0525-9

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells – Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell. https://www.jci.org/articles/view/131859

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression – Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu and Qing-Bai She. https://www.nature.com/articles/s41467-020-17067-x

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth – Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman and Mei Kong. https://www.nature.com/articles/s41467-020-17181-w


Lipid sensing and metabolism


Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms – Stephen L. Pinkosky, John W. Scott, Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Rebecca J. Ford, Christopher G. Langendorf, Naomi X. Y. Ling, Tracy L. Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William. Smiles, Kevin R. W. Ngoei, Michael W. Parker, Yan Yan, Karsten Melcher, Bruce E. Kemp, Jonathan S. Oakhill and Gregory R. Steinberg. https://www.nature.com/articles/s42255-020-0245-2

De Novo Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma – Nima Abbassi-Ghadi, Stefan S. Antonowicz, James S. McKenzie, Sacheen Kumar, Juzheng Huang, Emrys A. Jones, Nicole Strittmatter, Gemma Petts, Hiromi Kudo, Stephen Court, Jonathan M. Hoare, Kirill Veselkov, Robert Goldin, Zoltán Takáts and George B. Hanna. https://cancerres.aacrjournals.org/content/80/13/2764


Mitochondria and hypoxia


Mitochondrial ubiquinol oxidation is necessary for tumour growth – Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S. McElroy, Marie Werner, Hermon Kihshen, Colleen R. Reczek, Samuel E. Weinberg, Peng Gao, Elizabeth M. Steinert, Raul Piseaux, G. R. Scott Budinger and Navdeep S. Chandel. https://www.nature.com/articles/s41586-020-2475-6

Na+ controls hypoxic signalling by the mitochondrial respiratory chainPablo Hernansanz-Agustín, Carmen Choya-Foces, Susana Carregal-Romero, Elena Ramos, Tamara Oliva, Tamara Villa-Piña, Laura Moreno, Alicia Izquierdo-Álvarez, J. Daniel Cabrera-García, Ana Cortés, Ana Victoria Lechuga-Vieco, Pooja Jadiya, Elisa Navarro, Esther Parada, Alejandra Palomino-Antolín, Daniel Tello, Rebeca Acín-Pérez, Juan Carlos Rodríguez-Aguilera, Plácido Navas, Ángel Cogolludo, Iván López-Montero, Álvaro Martínez-del-Pozo, Javier Egea, Manuela G. López, John W. Elrod, Jesús Ruíz-Cabello, Anna Bogdanova, José Antonio Enríquez and Antonio Martínez-Ruiz. https://www.nature.com/articles/s41586-020-2551-y

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells – Jie Li , Ekta Agarwal, Irene Bertolini, Jae Ho Seo, M. Cecilia Caino, Jagadish C. Ghosh, Andrew V. Kossenkov, Qin Liu, Hsin-Yao Tang, Aaron R. Goldman, Lucia R. Languino, David W. Speicher, Dario C. Altieri. https://stke.sciencemag.org/content/13/642/eaaz8240

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival – Cesar Cardenas , Alenka Lovy, Eduardo Silva-Pavez, Felix Urra, Craig Mizzoni, Ulises Ahumada-Castro, Galdo Bustos, Fabian Jaňa, Pablo Cruz, Paula Farias, Elizabeth Mendoza, Hernan Huerta, Paola Murgas, Martin Hunter, Melany Rios, Oscar Cerda, Irene Georgakoudi, Armen Zakarian, Jordi Molgó, J. Kevin Foskett. https://stke.sciencemag.org/content/13/640/eaay1212

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells by modulating metabolism and death pathways – J. Vial, P. Huchedé, S. Fagault, F. Basset, M. Rossi, J. Geoffray, H. Soldati, J. Bisaccia, M. H. Elsensohn, M. Creveaux, D. Neves, J. Y. Blay, F. Fauvelle, F. Bouquet, N. Streichenberger, N. Corradini, C. Bergeron, D. Maucort-Boulch, P. Castets, M. Carré, K. Weber and M. Castets. https://www.nature.com/articles/s41420-020-00302-1

Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth – L. M. Schiffmann, J. P. Werthenbach, F. Heintges-Kleinhofer, J. M. Seeger, M. Fritsch, S. D. Günther, S. Willenborg, S. Brodesser, C. Lucas, C. Jüngst, M. C. Albert, F. Schorn, A. Witt, C. T. Moraes, C. J. Bruns, M. Pasparakis, M. Krönke, S. A. Eming, O. Coutelle and H. Kashkar. https://www.nature.com/articles/s41467-020-17472-2

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells – Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00219-4


Starvation/metabolic stress


Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damageJoffrey Pelletier, Ferran Riaño‐Canalias, Eugènia Almacellas, Caroline Mauvezin, Sara Samino, Sonia Feu, Sandra Menoyo, Ana Domostegui, Marta Garcia‐Cajide, Ramon Salazar, Constanza Cortés, Ricard Marcos, Albert Tauler, Oscar Yanes, Neus Agell, Sara C Kozma, Antonio Gentilella, George Thomas. https://www.embopress.org/doi/full/10.15252/embj.2019103838

Systematic quantitative analysis of ribosome inventory during nutrient stress – Heeseon An, Alban Ordureau, Maria Körner, Joao A. Paulo and J. Wade Harper. https://www.nature.com/articles/s41586-020-2446-y

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress – Ahmad Kobiita, Svenja Godbersen, Elisa Araldi, Umesh Ghoshdastider, Marc W. Schmid, Giatgen Spinas, Holger Moch, Markus Stoffel. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30827-5


AMPK/mTOR


VRK-1 extends life span by activation of AMPK via phosphorylation – Sangsoon Park , Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, Seung-Jae V. Lee. https://advances.sciencemag.org/content/6/27/eaaw7824

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndromeGennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E. G. de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagnì, Pier Paolo Di Fiore, Lukas A. Huber and Andrea Ballabio. https://www.nature.com/articles/s41586-020-2444-0


Metabolic reprogramming (general)


Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma – Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden  . https://elifesciences.org/articles/56782

The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolismM. Carmen Lafita-Navarro, Lizbeth Perez-Castro, Lauren G. Zacharias, Spencer Barnes, Ralph J. DeBerardinis and Maralice Conacci-Sorrell. http://www.jbc.org/content/early/2020/07/01/jbc.AC120.014189.abstract 

Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells – Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova and Mónica Marín. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00216-7


Cancer Immunometabolism


An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells – Shogo Kumagai, Yosuke Togashi, Chika Sakai, Akihito Kawazoe, Masahito Kawazu, Toshihide Ueno, Eiichi Sato, Takeshi Kuwata, Takahiro Kinoshita, Masami Yamamoto, Sachiyo Nomura, Tetsuya Tsukamoto, Hiroyuki Mano, Kohei Shitara, Hiroyoshi Nishikawa. https://www.cell.com/immunity/fulltext/S1074-7613(20)30271-5

Tumors induce de novo steroid biosynthesis in T cells to evade immunity – Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields and Sarah A. Teichmann. https://www.nature.com/articles/s41467-020-17339-6

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells – Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell. https://www.jci.org/articles/view/131859


Methods


Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers – Andre Koit, Natalja Timohhina, Laura Truu, Vladimir Chekulayev, Shivakumar Gudlawar, Igor Shevchuk, Katrin Lepik, Lea Mallo, Riina Kutner, Vahur Valvere and Tuuli Kaambre. https://www.frontiersin.org/articles/10.3389/fonc.2020.01053/full

Metabolite AutoPlotter – an application to process and visualise metabolite data in the web browser – Matthias Pietzke and Alexei Vazquez. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00220-x


Miscellaneous


Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility – James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30861-5

Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscleCristina Sánchez‐González, Cristina Nuevo‐Tapioles, Juan Cruz Herrero Martín, Marta P Pereira, Sandra Serrano Sanz, Ana Ramírez de Molina, José M Cuezva, Laura Formentini. https://www.embopress.org/doi/full/10.15252/embj.2019103812

Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma – Anil R. Singh, Juan J. Gu, Qunling Zhang, Pallawi Torka, Suchitra Sundaram, Cory Mavis and Francisco J. Hernandez-Ilizaliturri. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00213-w


Reviews


Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments – Fuming Li, M. Celeste Simon. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30497-4

Lactate: the ugly duckling of energy metabolism – Joshua D. Rabinowitz and Sven Enerbäck. https://www.nature.com/articles/s42255-020-0243-4

Metabolite sensing and signaling in Cancer – Yi-Ping Wang, Jin-Tao Li, Jia Qu, Miao Yin and Qun-Ying Lei. http://www.jbc.org/content/early/2020/07/07/jbc.REV119.007624.abstract

Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer ImmunotherapyElisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo, Tomás Alarcón,Ruth Lupu, Joaquim Bosch-Barrera and Javier A. Menendez. https://www.mdpi.com/2072-6694/12/7/1757

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy? – Hannah J. Smith, Arpit Sharma, William B. Mair. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30461-5

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational ModificationsOscar A. Tarazona, Olivier Pourquié. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30543-8

Integration of Hippo-YAP Signaling with MetabolismConsuelo Ibar, Kenneth D. Irvine. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30504-9

The Lysosome at the Intersection of Cellular Growth and Destruction – Hijai R. Shin, Roberto Zoncu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30460-3

Fructose contributes to the Warburg effect for cancer growth – Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan and Richard J. Johnson. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00222-9

Mitochondrial Stress Response and Cancer – Jordan O’Malley, Rahul Kumar, Joseph Inigo, Nagendra Yadava, Dhyan Chandra. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30139-4

Metabolic Modulation of Immunity: A New Concept in Cancer ImmunotherapyLuana Guerra, Lynn Bonetti, Dirk Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30829-9


Comments


A spoonful of DHAP keeps mTORC1 running on sugars – Gerta Hoxhaj, Jason W. Locasale and Issam Ben-Sahra. https://www.nature.com/articles/s42255-020-0246-1

AMPK as a direct sensor of long-chain fatty acyl–CoA estersD. Grahame Hardie. https://www.nature.com/articles/s42255-020-0249-y

A ‘fast’er way to treat breast cancer – Marcus D. Goncalves and Lewis C. Cantley. https://www.nature.com/articles/s42255-020-0225-6

Starve a cold, and perhaps a cancer – Daniel Haensel and Anthony E. Oro. https://www.nature.com/articles/s41556-020-0543-7

Integrating serine with tumour initiation – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-0287-5

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