MetaboList – August 2020


Amino acids


Serine restriction alters sphingolipid diversity to constrain tumour growth – Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani Gengatharan, Antonio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace, Alan Saghatelian and Christian M. Metallo. https://www.nature.com/articles/s41586-020-2609-x

Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis – Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31006-8

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway – Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan and Jeffrey A. Moscow. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00214-9

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model – Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N. Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, François Vallette, Woo-Ping Ge, François Paris, Ralph J. DeBerardinis and Claire Pecqueur. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00215-8

Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours – Ziwen Zhu, Abhinav Achreja, Noah Meurs, Olamide Animasahun, Sarah Owen, Anjali Mittal, Pooja Parikh, Ting-Wen Lo, Janusz Franco-Barraza, Jiaqi Shi, Valerie Gunchick, Mara H. Sherman, Edna Cukierman, Andrew M. Pickering, Anirban Maitra, Vaibhav Sahai, Meredith A. Morgan, Sunitha Nagrath, Theodore S. Lawrence and Deepak Nagrath. https://www.nature.com/articles/s42255-020-0226-5


Glucose metabolism


HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors – Kangjing Xu, Zhongyuan He, Ming Chen, Nuofan Wang, Diancai Zhang, Li Yang, Zekuan Xu and Hao Xu. https://www.nature.com/articles/s41419-020-02768-4

p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis – Fang Wang, Xiao-Mei Qi, Ryan Wertz, Matthew Mortensen, Catherine Hagen, John Evans, Yuri Sheinin, Michael James, Pengyuan Liu, Susan Tsai, James Thomas, Alexander Mackinnon, Michael Dwinell, Charles R. Myers, Ramon Bartrons Bach, Liwu Fu and Guan Chen. https://cancerres.aacrjournals.org/content/80/16/3251

Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer – Elisabeth Smolle, Petra Leko, Elvira Stacher‐Priehse, Luka Brcic, Amin El‐Heliebi, Lilli Hofmann, Franz Quehenberger, Andelko Hrzenjak, Helmut H. Popper, Horst Olschewski, Katharina Leithner. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12780


Lipid metabolism


Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress – Xiang Cheng, Feng Geng, Meixia Pan, Xiaoning Wu, Yaogang Zhong, Chunyan Wang, Zhihua Tian, Chunming Cheng, Rui Zhang, Vinay Puduvalli, Craig Horbinski, Xiaokui Mo, Xianlin Han, Arnab Chakravarti, Deliang Guo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30303-X

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites – Claudie Bosc, Nicolas Broin, Marjorie Fanjul, Estelle Saland, Thomas Farge, Charly Courdy, Aurélie Batut, Rawand Masoud, Clément Larrue, Sarah Skuli, Nicolas Espagnolle, Jean-Christophe Pagès, Alice Carrier, Frédéric Bost, Justine Bertrand-Michel, Jérôme Tamburini, Christian Récher, Sarah Bertoli, Véronique Mansat-De Mas, Stéphane Manenti, Jean-Emmanuel Sarry and Carine Joffre. https://www.nature.com/articles/s41467-020-17882-2

Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression – Ji Hye Yang, Nam Hee Kim, Jun Seop Yun, Eunae Sandra Cho, Yong Hoon Cha, Sue Bean Cho, Seon-Hyeong Lee, So Young Cha, Soo-Youl Kim, Jiwon Choi, Tin-Tin Manh Nguyen, Sunghyouk Park, Hyun Sil Kim and Jong In Yook. https://www.life-science-alliance.org/content/3/7/e202000683.abstract

Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells – James Drury, Piotr G. Rychahou, Daheng He, Naser Jafari, Yekaterina Y. Zaytseva, Chi Wang, Eun Y. Lee, Heidi L. Weiss, and Bernard Mark Evers. https://www.frontiersin.org/articles/10.3389/fonc.2020.01185/full


Nucleotides


Purine metabolism regulates DNA repair and therapy resistance in glioblastoma – Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis and Daniel R. Wahl. https://www.nature.com/articles/s41467-020-17512-x

New regulatory mechanism‐based inhibitors of aspartate transcarbamoylase for potential anticancer drug development – Zhen Lei, Biying Wang, Zhifang Lu, Nan Wang, Hongwei Tan, Jimin Zheng, Zongchao Jia. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15220

Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage – Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31062-7


Mitochondria


Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria – Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter. https://elifesciences.org/articles/58041

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression – Yotaro Kudo, Masayuki Sugimoto, Esperanza Arias, Hiroaki Kasashima, Thekla Cordes, Juan F. Linares, Angeles Duran, Yuki Nakanishi, Naoko Nakanishi, Antoine L’Hermitte, Alex Campos, Nadia Senni, Tarmo Rooslid, Lewis R. Roberts, Ana Maria Cuervo, Christian M. Metallo, Michael Karin, Maria T. Diaz-Meco, Jorge Moscat. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30268-3

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex – Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza and James A. Nathan. https://www.nature.com/articles/s41467-020-17862-6

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite – Minervo Perez, Daniel W. Bak, Sarah E. Bergholtz, Daniel R Crooks, Bhargav Srinivas Arimilli, Youfeng Yang, Eranthie Weerapana, W. Marston Linehan and Jordan L. Meier. http://www.jbc.org/content/early/2020/08/19/jbc.AC120.014993.abstract

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition – Alba Roca-Portoles, Giovanny Rodriguez-Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian M. Mackay, Katelyn O’Neill, Leandro Lemgruber, Xu Luo & Stephen W. G. Tait. https://www.nature.com/articles/s41419-020-02867-2


Starvation


p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth – Ada Nowosad, Pauline Jeannot, Caroline Callot, Justine Creff, Renaud Thierry Perchey, Carine Joffre, Patrice Codogno, Stephane Manenti and Arnaud Besson. https://www.nature.com/articles/s41556-020-0554-4

Glutamine deprivation alters the origin and function of cancer cell exosomes – Shih‐Jung Fan, Benjamin Kroeger, Pauline P Marie, Esther M Bridges, John D Mason, Kristie McCormick, Christos E Zois, Helen Sheldon, Nasullah Khalid Alham, Errin Johnson, Matthew Ellis, Maria Irina Stefana, Cláudia C Mendes, Stephen Mark Wainwright, Christopher Cunningham, Freddie C Hamdy, John F Morris, Adrian L Harris, Clive Wilson, Deborah CI Goberdhan. https://www.embopress.org/doi/full/10.15252/embj.2019103009


Hypoxia


Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment – Irene Bertolini. Jagadish C. Ghosh. Andrew V. Kossenkov. Sudheer Mulugu. Shiv Ram Krishn. Valentina Vaira. Jun Qin. Edward F. Plow. Lucia R. Languino. Dario C. Altieri. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30588-8

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice – Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries and Ian J. Frew. https://www.nature.com/articles/s41467-020-17873-3


Miscellaneous


Lymph protects metastasizing melanoma cells from ferroptosis – Jessalyn M. Ubellacker, Alpaslan Tasdogan, Vijayashree Ramesh, Bo Shen, Evann C. Mitchell, Misty S. Martin-Sandoval, Zhimin Gu, Michael L. McCormick, Alison B. Durham, Douglas R. Spitz, Zhiyu Zhao, Thomas P. Mathews and Sean J. Morrison. https://www.nature.com/articles/s41586-020-2623-z

Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin – Ramy Ayoub, Rebecca M. Ruddy, Elizabeth Cox, Adeoye Oyefiade, Daniel Derkach, Suzanne Laughlin, Benjamin Ades-aron, Zahra Shirzadi, Els Fieremans, Bradley J. MacIntosh, Cynthia B. de Medeiros, Jovanka Skocic, Eric Bouffet, Freda D. Miller, Cindi M. Morshead and Donald J. Mabbott. https://www.nature.com/articles/s41591-020-0985-2

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice – Rowena Suriben, Michael Chen, Jared Higbee, Julie Oeffinger, Richard Ventura, Betty Li, Kalyani Mondal, Zhengyu Gao, Dina Ayupova, Pranali Taskar, Diana Li, Shelley R. Starck, Hung-I Harry Chen, Michele McEntee, Subhash D. Katewa, Van Phung, Marilyn Wang, Avantika Kekatpure, Damodharan Lakshminarasimhan, Andre White, Andrea Olland, Raj Haldankar, Mark J. Solloway, Jer-Yuan Hsu, Yan Wang, Jie Tang, Darrin A. Lindhout and Bernard B. Allan. https://www.nature.com/articles/s41591-020-0945-x

In situ Metabolic Profiling of Ovarian Cancer Tumor Xenografts: A Digital Pathology Approach – Ilaria Piga, Martina Verza, Francesca Montenegro, Giorgia Nardo, Elisabetta Zulato, Tiziana Zanin, Paola Del Bianco, Giovanni Esposito and Stefano Indraccolo. https://www.frontiersin.org/articles/10.3389/fonc.2020.01277/full


Reviews


Lactate modulation of immune responses in inflammatory versus tumour microenvironments – Michelangelo Certo, Chin-Hsien Tsai, Valentina Pucino, Ping-Chih Ho and Claudio Mauro. https://www.nature.com/articles/s41577-020-0406-2

Glycolysis – a key player in the inflammatory response – Gonzalo Soto‐Heredero, Manuel M. Gómez de las Heras, Enrique Gabandé‐Rodríguez, Jorge Oller, María Mittelbrunn. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15327

Tracking the carbons supplying gluconeogenesis – Ankit M. Shah and Fredric E. Wondisford. http://www.jbc.org/content/early/2020/08/13/jbc.REV120.012758.abstract

Metabolism and the Epigenome: A Dynamic Relationship – Spencer A. Haws, Cassandra M. Leech, John M. Denu. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30092-X

Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks – Rachel J. Perry and Gerald I. Shulman. http://www.jbc.org/content/early/2020/08/12/jbc.REV120.008387.abstract

Metabolism of immune cells in cancer – Robert D. Leone and Jonathan D. Powell. https://www.nature.com/articles/s41568-020-0273-y

Endogenous toxic metabolites and implications in cancer therapy – Namgyu Lee, Meghan E. Spears, Anne E. Carlisle and Dohoon Kim. https://www.nature.com/articles/s41388-020-01395-9

Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth – Eivind Salmorin Birkeland, Lisa Maria Koch and Reinhard Dechant. https://www.frontiersin.org/articles/10.3389/fonc.2020.01561/full

Manipulation of Mitochondrial Plasticity Changes the Metabolic Competition Between “Foe” and “Friend” During Tumor Malignant Transformation – Hui Tian, Baofu Zhang, Liantao Li, Gang Wang, Huizhong Li and JunNian Zheng. https://www.frontiersin.org/articles/10.3389/fonc.2020.01692/full

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy – Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Daqing Zhao, Boyang Jason Wu and Xiangyan Li. https://www.frontiersin.org/articles/10.3389/fonc.2020.01510/full

The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation – Cyrielle L. Bouchez, Noureddine Hammad, Sylvain Cuvellier, Stéphane Ransac, Michel Rigoulet and Anne Devin. https://www.frontiersin.org/articles/10.3389/fonc.2020.01333/full

Oncology Therapeutics Targeting the Metabolism of Amino Acids – Muhammad N, Lee HM, Kim J. https://www.mdpi.com/2073-4409/9/8/1904

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions – Lavanya Ponnusamy, Sathan Raj Natarajan, Karthik Thangaraj, Ravi Manoharan. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20300986

Cholesterol metabolism: New functions and therapeutic approaches in cancer – Huanji Xu, Sheng Zhou, Qiulin Tang, Hongwei Xia, Feng Bi. https://www.sciencedirect.com/science/article/abs/pii/S0304419X2030113X

Inside the hypoxic tumour: reprogramming of the DDR and radioresistance – Katheryn Begg and Mahvash Tavassoli. https://www.nature.com/articles/s41420-020-00311-0


Comments


Give and take: competition for BCAAs in the tumour microenvironment – Russell E. Ericksen and Weiping Han. https://www.nature.com/articles/s42255-020-0239-0

PKCλ/ι Loss Induces Metabolic Reprogramming in Liver Cancer: Hitting Two Birds with One Stone? – Pierluigi Ramadori, Xin Li, Mathias Heikenwalder. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30364-0

Fasting-mimicking diet plus chemotherapy in breast cancer treatment – Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini and Filippo de Braud. https://www.nature.com/articles/s41467-020-18194-1

The IDH1 Inhibitor Ivosidenib May Slow IDH1-Mutant Glioma Progression – https://cancerdiscovery.aacrjournals.org/content/10/8/OF6

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