MetaboList – September 2020


Amino acid metabolism


Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition – Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley and Michael E. Pacold. https://cancerdiscovery.aacrjournals.org/content/10/9/1352

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance – Nick van Gastel, Jessica B. Spinelli, Azeem Sharda, Amir Schajnovitz, Ninib Baryawno, Catherine Rhee, Toshihiko Oki, Eliane Grace, Heather J. Soled, Jelena Milosevic, David B. Sykes, Peggy P. Hsu, Matthew G. Vander Heiden, Charles Vidoudez, Sunia A. Trauger, Marcia C. Haigis, David T. Scadden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30367-3

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism – Ruoyan Xu, William Jones, Ewa Wilcz‐Villega, Ana SH Costa, Vinothini Rajeeve, Robert B Bentham, Kevin Bryson, Ai Nagano, Busra Yaman, Sheila Olendo Barasa, Yewei Wang, Claude Chelala, Pedro Cutillas, Gyorgy Szabadkai, Christian Frezza, Katiuscia Bianchi. https://www.embopress.org/doi/full/10.15252/embr.201948260

Cancer proteome and metabolite changes linked to SHMT2 – Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237981Systemic muscle wasting and coordinated tumour response drive tumourigenesis – Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets and Susumu Hirabayashi. https://www.nature.com/articles/s41467-020-18502-9

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth – Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran and Chuanyue Wu. https://www.nature.com/articles/s41467-020-18753-6


Lipid metabolism


Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer – Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash and Timothy C. Thompson. https://www.nature.com/articles/s41467-020-17645-z

Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction – Manish Chamoli, Anita Goyala, Syed Shamsh Tabrez, Atif Ahmed Siddiqui, Anupama Singh, Adam Antebi, Gordon J. Lithgow, Jennifer L. Watts and Arnab Mukhopadhyay. https://www.nature.com/articles/s41467-020-18690-4


Nucleotides and NAD/PH


Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors – Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S. Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-wei Shen, Nir Peled, Igor Ulitsky, Angel Porgador, Eytan Ruppin and Ayelet Erez. https://www.nature.com/articles/s43018-020-0106-7

Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism – Muskan Bhatia, Jyotika Thakur, Shradha Suyal, Ruchika Oniel, Rahul Chakraborty, Shalini Pradhan, Monika Sharma, Shantanu Sengupta, Sunil Laxman, Shyam Kumar Masakapalli and Anand Kumar Bachhawat. http://www.jbc.org/content/early/2020/09/15/jbc.RA120.015129.abstract

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma – Anna E. Gibson, Choh Yeung, Sameer H. Issaq, Victor J. Collins, Michael Gouzoulis, Yiping Zhang, Jiuping Ji, Arnulfo Mendoza and Christine M. Heske. https://www.nature.com/articles/s41389-020-00264-0


Glucose metabolism


Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis – Jonathan M. Ghergurovich, Mark Esposito, Zihong Chen, Joshua Z. Wang, Vrushank Bhatt, Taijin Lan, Eileen White, Yibin Kang, Jessie Yanxiang Guo and Joshua D. Rabinowitz. https://cancerres.aacrjournals.org/content/80/18/3820

Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane – Yi Rao, Seth Gammon, Niki M. Zacharias, Tracy Liu, Travis Salzillo, Yuanxin Xi, Jing Wang, Pratip Bhattacharya, and David Piwnica-Worms. https://www.pnas.org/content/117/36/22378.abstract?etoc


Mitochondria


A Cellular Mechanism to Detect and Alleviate Reductive Stress – Andrew G. Manford, Fernando Rodríguez-Pérez, Karen Y. Shih, Zhuo Shi, Charles A. Berdan, Mangyu Choe, Denis V. Titov, Daniel K. Nomura, Michael Rape. https://www.cell.com/cell/fulltext/S0092-8674(20)31076-X

Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction – Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, Benjamin Olenchock, Eugene Rhee, Andrew M. Intlekofer, Othon Iliopoulos, Edward Chouchani and Jing-Ruey Joanna Yeh. https://cancerres.aacrjournals.org/content/80/17/3492 

Metabolic rewiring in drug resistant cells exhibit higher OXPHOS and fatty acids as preferred major source to cellular energetics – Sameer Salunkhe, Saket V. Mishra, Atanu Ghorai, Aarti Hole, Pratik Chandrani, Amit Dutt, Murali Chilakapati, Shilpee Dutt. https://www.sciencedirect.com/science/article/pii/S000527282030150X 

SLC25A51 is a mammalian mitochondrial NAD+ transporter – Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne and Joseph A. Baur. https://www.nature.com/articles/s41586-020-2741-7


Starvation


Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis – Bryan King, Jingwen Araki, Wilhelm Palm and Craig B. Thompson. http://genesdev.cshlp.org/content/34/19-20/1345.abstract?etoc

GADD34 is a modulator of autophagy during starvation – Gennaro Gambardella , Leopoldo Staiano, Maria Nicoletta Moretti, Rossella De Cegli, Luca Fagnocchi, Giuseppe Di Tullio, Sara Polletti, Clarissa Braccia, Andrea Armirotti, Alessio Zippo, Andrea Ballabio, Maria Antonietta De Matteis, Diego di Bernardo. https://advances.sciencemag.org/content/6/39/eabb0205

Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming – Caitlyn B. Brashears, Meltem Barlin, William R. Ehrhardt, Richa Rathore, Matthew Schultze, Shin-Chen Tzeng, Brian A. Van Tine and Jason M. Held. https://www.nature.com/articles/s41419-020-02899-8

Differential regulation of autophagy during metabolic stress in astrocytes and neurons – Aditi Kulkarni, Audrey Dong, Vineet Vinay Kulkarni, Jessica Chen, Olivia Laxton, Anip Anand and Sandra Maday. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1703354

Amino acid starvation inhibits autophagy in lipid droplet-deficient cells through mitochondrial dysfunction – Pierre Voisin, Marianne Bernard, Thierry Bergès, Matthieu Régnacq. https://portlandpress.com/biochemj/article-abstract/477/18/3613/226330


mTOR / AMPK


Phosphorylated Acetyl-CoA Carboxylase Is Associated with Clinical Benefit with Regorafenib in Relapsed Glioblastoma: REGOMA Trial Biomarker Analysis – Stefano Indraccolo, Gian Luca De Salvo, Martina Verza, Mario Caccese, Giovanni Esposito, Ilaria Piga, Paola Del Bianco, Marco Pizzi, Marina Paola Gardiman, Marica Eoli, Roberta Rudà, Alba Ariela Brandes, Toni Ibrahim, Simona Rizzato, Ivan Lolli, Vittorina Zagonel and Giuseppe Lombardi. https://clincancerres.aacrjournals.org/content/26/17/4478

Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling – Eleanor C. Warren, Stephanie Dooves, Eleonora Lugarà, Joseph Damstra-Oddy, Judith Schaf, Vivi M. Heine, Mathew C. Walker, and Robin S. B. Williams. https://www.pnas.org/content/117/38/23617.abstract?etoc

Cell death induced by dorsomorphin in adult T‐cell leukemia/lymphoma is AMPK‐independent – Akiyoshi Aikawa, Tomohiro Kozako, Yuichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Takeo Ohsugi, Shin‐ichiro Honda. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15239

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway – Erica De Zan , Ruud van Stiphout, Bianca V. Gapp, Vincent A. Blomen, Thijn R. Brummelkamp, Sebastian M.B. Nijman. https://stke.sciencemag.org/content/13/649/eaba5665 


IDH


Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells – Yi Xu, Yang Zhang, Juan C. García-Cañaveras, Lili Guo, Mengyuan Kan, Sixiang Yu, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang. https://science.sciencemag.org/content/369/6502/397/

Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma – Risheng Yang, Yuanlin Zhao, Yu Gu, Ying Yang, Xing Gao, Yuan Yuan, Liming Xiao, Jin Zhang, Chao Sun, Han Yang, Junhui Qin, Jing Li, Feng Zhang, Lijun Zhang and Jing Ye. https://www.nature.com/articles/s41388-020-01439-0 


Cancer Immunometabolism


Cancer SLC43A2 alters T cell methionine metabolism and histone methylation – Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Zeribe C. Nwosu, Li Zhang, Arkadiusz Czerwonka, Anna Pawłowska, Houjun Xia, Jing Li, Peng Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Rebecca Liu, Karen McLean, Marcin Cieslik, Arul M. Chinnaiyan, Witold Zgodziński, Grzegorz Wallner, Iwona Wertel, Karolina Okła, Ilona Kryczek, Costas A. Lyssiotis and Weiping Zou. https://www.nature.com/articles/s41586-020-2682-1

Seven-Gene Signature Based on Glycolysis Is Closely Related to the Prognosis and Tumor Immune Infiltration of Patients With Gastric Cancer – Shanshan Yu, Chuan Hu, Luya Cai, Xuedan Du, Fan Lin, Qiongjie Yu, Lixiao Liu, Cheng Zhang, Xuan Liu, Wenfeng Li, and Yu Zhan. https://www.frontiersin.org/articles/10.3389/fonc.2020.01778 


Metformin


AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation – Jeanine L. Van Nostrand, Kristina Hellberg, En-Ching Luo, Eric L. Van Nostrand, Alina Dayn, Jingting Yu, Maxim N. Shokhirev, Yelena Dayn, Gene W. Yeo and Reuben J. Shaw. http://genesdev.cshlp.org/content/34/19-20/1330.abstract?eto

Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial – Shuhong Wang, Yusheng Lin, Xiao Xiong, Lu Wang, Yi Guo, Yuping Chen, Shaobin Chen, Geng Wang, Peng Lin, Hongcai Chen, Sai-Ching Jim Yeung, Edwin Bremer and Hao Zhang. https://clincancerres.aacrjournals.org/content/26/18/4921

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways – Huairui Yuan, Ying Han, Xuege Wang, Ni Li, Qiuli Liu, Yuye Yin, Hanling Wang, Lulu Pan, Li Li, Kun Song, Tong Qiu, Qiang Pan, Qilong Chen, Guoying Zhang, Yi Zang, Minjia Tan, Jian Zhang, Qintong Li, Xiaoming Wang, Jun Jiang, Jun Qin. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30272-5


Miscellaneous


Age-induced accumulation of methylmalonic acid promotes tumour progression – Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt and John Blenis. https://www.nature.com/articles/s41586-020-2630-0

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas – Chan Chung, Stefan R. Sweha, Drew Pratt, Benita Tamrazi, Pooja Panwalkar, Adam Banda, Jill Bayliss, Debra Hawes, Fusheng Yang, Ho-Joon Lee, Mengrou Shan, Marcin Cieslik, Tingting Qin, Christian K. Werner, Daniel R. Wahl, Costas A. Lyssiotis, Zhiguo Bian, J. Brad Shotwell, Viveka Nand Yadav, Carl Koschmann, Arul M. Chinnaiyan, Stefan Blüml, Alexander R. Judkins, Sriram Venneti. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30369-X

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts – Wen-Chih Lee, Xing Ji, Itzhak Nissim, Fanxin Long. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31097-4

Defining the ATPome reveals cross-optimization of metabolic pathways – Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. https://www.nature.com/articles/s41467-020-18084-6

Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways – Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia and Jinglin Xia. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00225-6

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia – Martin Benej, Eliska Svastova, Radivojka Banova, Juraj Kopacek, Adriana Gibadulinova, Nicholas C. Denko, Martin Kery, Simona Arena, Andrea Scaloni, Monica Vitale, Nicola Zambrano, Ioanna Papandreou, and Silvia Pastorekova. https://www.frontiersin.org/articles/10.3389/fonc.2020.01462/full


Reviews


Mitochondrial Metabolism as a Target for Cancer Therapy – Karthik Vasan, Marie Werner, Navdeep S. Chandel. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30320-X

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take – Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt. https://www.embopress.org/doi/abs/10.15252/embr.202050635

Amino Assets: How Amino Acids Support Immunity – Beth Kelly, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30311-9 

Oxygen‐sensing mechanisms in cells – James W. Wilson, Dilem Shakir, Michael Batie, Mark Frost, Sonia Rocha. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15374 

If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease – Ffion R. Hammond, Amy Lewis, Philip M. Elks. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15476

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms – Clotilde Laussel, Sébastien Léon. https://www.sciencedirect.com/science/article/pii/S0006295220304494

Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis – Tao Jiang, Guangji Zhang and Zhaohuan Lou. https://www.frontiersin.org/articles/10.3389/fonc.2020.01788/full 

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications – Qinyao Wei, Yun Qian, Jun Yu and Chi Chun Wong. https://www.nature.com/articles/s41388-020-01432-7

Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring – Mariafrancesca Scalise, Lara Console, Filomena Rovella, Michele Galluccio, Lorena Pochini and Cesare Indiveri. https://www.mdpi.com/2073-4409/9/9/2028

Glutamine reliance in cell metabolism – Hee Chan Yoo, Ya Chun Yu, Yulseung Sung and Jung Min Han. https://www.nature.com/articles/s12276-020-00504-8

Metabolic Reprogramming is a Hallmark of Metabolism Itself – Miguel Ángel Medina. https://onlinelibrary.wiley.com/doi/10.1002/bies.202000058


Comments / other


Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation – Sharanya Sivanand and Matthew G. Vander Heiden. http://genesdev.cshlp.org/content/34/19-20/1253.abstract?etoc 

Cancer cells stock up in lymph vessels to survive – Barbara M. Grüner, Sarah-Maria Fendt. https://www.nature.com/articles/d41586-020-02383-5

ASS1igning purine dependency to cancer – Elodie Villa & Issam Ben-Sahra. https://www.nature.com/articles/s43018-020-00117-0

AMPK as a direct sensor of long-chain fatty acyl–CoA esters – D. Grahame Hardie. https://www.nature.com/articles/s42255-020-0249-y

Microenvironmental Aspartate Preserves Leukemic Cells from Therapy-Induced Metabolic Collapse – Lucille Stuani, Jean-Emmanuel Sarry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30421-6

An Antibody Attack against Body Wasting in Cancer – Maria Rohm, Stephan Herzig. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30416-2

Mitochondrial Oxidation of Ubiquinol Is Required for Tumorigenesishttps://cancerdiscovery.aacrjournals.org/content/10/9/1250.1


Paolo Sassone-Corsi (1956–2020) – Selma Masri, Colin R. Goding, Todd Leff. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30608-0

A tribute to Beth Levine (1960–2020) – Ralph J. DeBerardinis. https://www.jci.org/articles/view/142454


ISCaM 7th Annual Meeting Webinar Series, with focus on Systemic Metabolism and Cancer.

  • Systemic Metabolism and Cancer 1: Cancer Therapy and Diet. 20 October, 2020, 4pm. Karen Vousden, Valter D Longo, Jason W Locasale, Almut Schulze, 
  • Systemic Metabolism and Cancer 2: The Tumour Microenvironment. 27 October, 2020, 4pm. Jean-Ehrland Ricci, Katiuscia Bianchi, Kathrin Renner 

Direct access: https://drive.google.com/file/d/1On-B0W74p6BgZpEDX1JqQChm_dVbcifo/view?usp=sharing

EMBO Workshop: Cancer Immunometabolism

Organizers: Cristina Muñoz-Pinedo, Jean-Ehrland Ricci, Eric Eldering

Sitges (Barcelona), Spain, March 15-17 2021

https://meetings.embo.org/event/21-cancer

2 thoughts on “MetaboList – September 2020

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