MetaboList – October 2020


Amino acid metabolism


Serine restriction alters sphingolipid diversity to constrain tumour growth – Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani Gengatharan, Antonio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace, Alan Saghatelian and Christian M. Metallo. https://www.nature.com/articles/s41586-020-2609-x

Polyamine pathway activity promotes cysteine essentiality in cancer cells – Tong Zhang, Christin Bauer, Alice C. Newman, Alejandro Huerta Uribe, Dimitris Athineos, Karen Blyth and Oliver D. K. Maddocks. https://www.nature.com/articles/s42255-020-0253-2

Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells – Rohiverth Guarecuco , Robert T. Williams, Lou Baudrier, Konnor La, Maria C. Passarelli, Naz Ekizoglu, Mert Mestanoglu, Hanan Alwaseem, Bety Rostandy, Justine Fidelin, Javier Garcia-Bermudez, Henrik Molina, Kivanç Birsoy. https://advances.sciencemag.org/content/6/41/eabc7120

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer – Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards. https://elifesciences.org/articles/56749

Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers – Yao-An Shen, Jiaxin Hong, Ryoichi Asaka, Shiho Asaka, Fang-Chi Hsu, Yohan Suryo Rahmanto, Jin-Gyoung Jung, Yu-Wei Chen, Ting-Tai Yen, Alicja Tomaszewski, Cissy Zhang, Nabeel Attarwala, Angelo M. DeMarzo, Ben Davidson, Chi-Mu Chuang, Xi Chen, Stephanie Gaillard, Anne Le, Ie-Ming Shih and Tian-Li Wang. https://cancerres.aacrjournals.org/content/80/20/4514

Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting – Hawley E Kunz, Jessica M Dorschner, Taylor E Berent, Thomas Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar and Ian R. Lanza. http://www.jbc.org/content/early/2020/10/01/jbc.RA120.014884.abstract


Glucose metabolism


Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle – Shiyu Liu, Ziwei Dai, Daniel E Cooper, David G Kirsch, Jason W Locasale. https://www.sciencedirect.com/science/article/abs/pii/S1550413120304836

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma – Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31282-1

Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation – Suparno Nandi, Mortezaali Razzaghi, Dhiraj Srivastava and Mishtu Dey. http://www.jbc.org/content/early/2020/09/28/jbc.RA120.015800.abstract

Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer – Bei Li, Qian Yang, Zhiyu Li, Zhiliang Xu, Si Sun, Qi Wu, and Shengrong Sun. https://www.frontiersin.org/articles/10.3389/fonc.2020.574787/full

Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer – Jiyoung Kim, Jengmin Kang, Ye-Lim Kang, Jongmin Woo, Youngsoo Kim, June Huh and Jong-Wan Park. https://www.nature.com/articles/s41467-020-19263-1


Lipid metabolism


Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase – Angela Maria Savino, Sara Isabel Fernandes, Orianne Olivares, Anna Zemlyansky, Antony Cousins, Elke K. Markert, Shani Barel, Ifat Geron, Liron Frishman, Yehudit Birger, Cornelia Eckert, Sergey Tumanov, Gillian MacKay, Jurre J. Kamphorst, Pawel Herzyk, Jonatan Fernández-García, Ifat Abramovich, Inbal Mor, Michela Bardini, Ersilia Barin, Sudha Janaki-Raman, Justin R. Cross, Michael G. Kharas, Eyal Gottlieb, Shai Izraeli and Christina Halsey. https://www.nature.com/articles/s43018-020-00115-2

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer – Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri, Janusz Franco-Barraza, Diana Restifo, Nicole Weitz, Charline Ogier, Aaron R. Goldman, Tiffiney R. Hartman, Ralph Francescone, Yinfei Tan, Emmanuelle Nicolas, Neelima Shah, Elizabeth A. Handorf, Kathy Q. Cai, Alana M. O’Reilly, Ido Sloma, Rachel Chiaverelli, Richard A. Moffitt, Vladimir Khazak, Carolyn Y. Fang, Erica A. Golemis, Edna Cukierman, Igor Astsaturov. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30426-8

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype – Virginia Lope, Ángel Guerrero-Zotano, Ana Casas, José Manuel Baena-Cañada, Begoña Bermejo, Beatriz Pérez-Gómez, Inmaculada Criado-Navarro, Silvia Antolín, Pedro Sánchez-Rovira, Manuel Ramos-Vázquez, Antonio Antón, Adela Castelló, José Ángel García-Saénz, Montserrat Muñoz, Ana de Juan, Raquel Andrés, Antonio Llombart-Cussac, Blanca Hernando, Rosa María Franquesa, Rosalia Caballero, Feliciano Priego-Capote, Miguel Martín and Marina Pollán. https://www.mdpi.com/2072-6643/12/10/3132

Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem–Like Cells and Reduces Metastases through Effects on Lipid Anabolism – Rosanna Dattilo, Carla Mottini, Emanuela Camera, Alessia Lamolinara, Noam Auslander, Ginevra Doglioni, Michela Muscolini, Wei Tang, Melanie Planque, Cristiana Ercolani, Simonetta Buglioni, Isabella Manni, Daniela Trisciuoglio, Alessandra Boe, Sveva Grande, Anna Maria Luciani, Manuela Iezzi, Gennaro Ciliberto, Stefan Ambs, Ruggero De Maria, Sarah-Maria Fendt, Eytan Ruppin and Luca Cardone. https://cancerres.aacrjournals.org/content/80/19/4087


Mitochondria and nucleotides


MCART1/SLC25A51 is required for mitochondrial NAD transport – Nora Kory, Jelmi uit de Bos, Sanne van der Rijt, Nevena Jankovic, Miriam Güra, Nicholas Arp, Izabella A. Pena, Gyan Prakash, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini. https://advances.sciencemag.org/content/early/2020/09/08/sciadv.abe5310

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis – Zhen Cai, Chien-Feng Li, Fei Han, Chunfang Liu, Anmei Zhang, Che-Chia Hsu, Danni Peng, Xian Zhang, Guoxiang Jin, Abdol-Hossein Rezaeian, Guihua Wang, Weina Zhang, Bo-Syong Pan, Chi-Yun Wang, Yu-Hui Wang, Shih-Ying Wu, Shun-Chin Yang, Fang-Chi Hsu, Ralph B. D’Agostino Jr., Christina M. Furdui, Gregory L. Kucera, John S. Parks, Floyd H. Chilton, Chih-Yang Huang, Fuu-Jen Tsai, Boris Pasche, Kounosuke Watabe, Hui-Kuan Lin. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30648-1

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells – Sandra Valle, Sonia Alcalá, Laura Martin-Hijano, Pablo Cabezas-Sáinz, Diego Navarro, Edurne Ramos Muñoz, Lourdes Yuste, Kanishka Tiwary, Karolin Walter, Laura Ruiz-Cañas, Marta Alonso-Nocelo, Juan A. Rubiolo, Emilio González-Arnay, Christopher Heeschen, Laura Garcia-Bermejo, Patrick C. Hermann, Laura Sánchez, Patricia Sancho, Miguel Ángel Fernández-Moreno and Bruno Sainz Jr. https://www.nature.com/articles/s41467-020-18954-z

Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis – Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom and Laura C. Greaves. https://www.nature.com/articles/s43018-020-00112-5

Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma – Yu Qian, Xiao Liang, Pengzhou Kong, Yikun Cheng, Heyang Cui, Ting Yan, Jinghao Wang, Ling Zhang, Yiqian Liu, Shiping Guo, Xiaolong Cheng and Yongping Cui. https://www.nature.com/articles/s41419-020-03044-1


Starvation and metabolic stress


Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation – Chan Lee, Lilian Lamech, Eleanor Johns, Michael Overholtzer. https://www.sciencedirect.com/science/article/abs/pii/S1534580720306663

Metabolic control of acclimation to nutrient deprivation dependent on polyphosphate synthesis – Sanz-Luque , S. Saroussi, W. Huang, N. Akkawi, A. R. Grossman. https://advances.sciencemag.org/content/6/40/eabb5351

Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism – Alexander I. May, Mark Prescott and Yoshinori Ohsumi. https://www.nature.com/articles/s41467-020-18805-x

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition – Takefumi Onodera, Isao Momose, Hayamitsu Adachi, Yohko Yamazaki, Ryuichi Sawa, Shun-ichi Ohba and Manabu Kawada. http://www.jbc.org/content/early/2020/09/25/jbc.RA120.013893.abstract


Nutrient sensing / AMPK


The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids – Geoffrey G. Hesketh, Fotini Papazotos, Judy Pawling, Dushyandi Rajendran, James D. R. Knight, Sebastien Martinez, Mikko Taipale, Daniel Schramek, James W. Dennis, Anne-Claude Gingras. https://science.sciencemag.org/content/370/6514/351

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation – Steffi Heidenreich, Pamela Weber, Heike Stephanowitz, Konstantin M. Petricek, Till Schütte, Moritz Oster, Antti M. Salo, Miriam Knauer, Isabel Goehring, Na Yang, Nicole Witte, Anne Schumann, Manuela Sommerfeld, Matthias Muenzner, Johanna Myllyharju, Eberhard Krause and Michael Schupp. http://www.jbc.org/content/early/2020/10/06/jbc.RA120.014402.abstract

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking – Maria Casas, Rut Fadó, José Luis Domínguez, Aina Roig, Moena Kaku, Shigeru Chohnan, Montse Solé, Mercedes Unzeta, Alfredo Jesús Miñano-Molina, José Rodríguez-Álvarez, Eamonn James Dickson, Núria Casals. https://rupress.org/jcb/article/219/10/e201912045/152088

AMP-independent activator of AMPK for treatment of mitochondrial disorders – Tereza Moore, Rolando E Yanes, Melissa A Calton, Douglas Vollrath, Gregory M Enns, Tina M Cowan. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240517


Hypoxia


Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer – Kate E.R. Hollinshead, Seth J. Parker, Vinay V. Eapen, Joel Encarnacion-Rosado, Albert Sohn, Tugba Oncu, Michael Cammer, Joseph D. Mancias, Alec C. Kimmelman. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31220-1

Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment – Irene Bertolini, Jagadish C. Ghosh, Andrew V. Kossenkov, Sudheer Mulugu, Shiv Ram Krishn, Valentina Vaira, Jun Qin, Edward F. Plow, Lucia R. Languino, Dario C. Altieri. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30588-8

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia – Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian H. Heidel, Tina M. Schnöder, Spasenija Savic Prince, Lukas Bubendorf, Paolo Pinton, Ralph A. Schmid, Johanna Baumgartner, Stefan Freigang, Sabina A. Berezowska, Alessandro Rimessi and Georgia Konstantinidou. https://www.nature.com/articles/s41556-020-00592-8


IDH


Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition – Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert and Mioara Larion. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00229-2

Poly(ADP-ribose) Glycohydrolase Inhibition Sequesters NAD+ to Potentiate the Metabolic Lethality of Alkylating Chemotherapy in IDH-Mutant Tumor Cells – Hiroaki Nagashima, Christine K. Lee, Kensuke Tateishi, Fumi Higuchi, Megha Subramanian, Seamus Rafferty, Lisa Melamed, Julie J. Miller, Hiroaki Wakimoto and Daniel P. Cahill. https://cancerdiscovery.aacrjournals.org/content/10/11/1672  


Cancer Immunometabolism


Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells – Valentí Gómez , Thomas R. Eykyn, Rami Mustapha, Fabián Flores-Borja, Victoria Male, Paul R. Barber, Antonia Patsialou, Ryan Green, Fani Panagaki, Chun W. Li, Gilbert O. Fruhwirth, Susana Ros, Kevin M. Brindle, Tony Ng. https://stke.sciencemag.org/content/13/652/eaax4585

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis – Peishan Li, Ming Lu, Jiayuan Shi, Zheng Gong, Li Hua, Qing Li, Bora Lim, Xiang H.-F. Zhang, Xiaowen Chen, Sheng Li, Leonard D. Shultz and Guangwen Ren. https://www.nature.com/articles/s41590-020-0783-5


Metabolic inhibitors


5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation – Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers and Kang-Yell Choi. https://www.nature.com/articles/s41467-020-19173-2

Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma – Qinchao Hu, Jianmin Peng, Laibo Jiang, Wuguo Li, Qiao Su, Jiayu Zhang, Huan Li, Ming Song, Bin Cheng, Juan Xia and Tong Wu. https://www.nature.com/articles/s41419-020-03126-0


Miscellaneous


Probing single-cell metabolism reveals prognostic value of highly metabolically active circulating stromal cells in prostate cancer – Francesca Rivello , Kinga Matula, Aigars Piruska, Minke Smits, Niven Mehra, Wilhelm T. S. Huck. https://advances.sciencemag.org/content/6/40/eaaz3849

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense – Marta Bosch Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocío Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M. Templin, James E. B. Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A. Del Pozo, Matthew J. Sweet, Patricia T. Bozza, Steven P. Gross, Robert G. Parton, Albert Pol. https://science.sciencemag.org/content/370/6514/eaay8085

Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins – J.J. Hulmi, F. Penna, N. Pöllänen, T.A. Nissinen, J. Hentilä, L. Euro, J.H. Lautaoja, R. Ballarò, R. Soliymani, M. Baumann, O. Ritvos, E. Pirinen, M. Lalowski. https://www.sciencedirect.com/science/article/pii/S2212877820301204

Macrophage-derived glutamine boosts satellite cells and muscle regeneration – Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien De Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquière, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi and Massimiliano Mazzone. https://www.nature.com/articles/s41586-020-2857-9

Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling – Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo, Marco Vanoni, Christian M. Metallo, Rosa Maria Moresco and Lilia Alberghina. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00227-4


Reviews


Immunometabolic Interplay in the Tumor Microenvironment – Irem Kaymak, Kelsey S. Williams, Jason R. Cantor, Russell G. Jones. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30478-5#.X5r5lrvYA_U

The Janus-like role of proline metabolism in cancer – Lynsey Burke, Inna Guterman, Raquel Palacios Gallego, Robert G. Britton, Daniel Burschowsky, Cristina Tufarelli and Alessandro Rufini. https://www.nature.com/articles/s41420-020-00341-8

Filament formation by metabolic enzymes—A new twist on regulation – Eric M. Lynch, Justin M. Kollman, Bradley A. Webb. https://www.sciencedirect.com/science/article/abs/pii/S0955067420300521

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology – J. Kierans  C. T. Taylor. https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280572

Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy – Stephen M. Hatfield and Michail V. Sitkovsky. https://www.jci.org/articles/view/137554

Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth – Birkeland ES, Koch LM, Dechant R. https://www.frontiersin.org/articles/10.3389/fonc.2020.01561/full

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors – Marjolein M G Kes, Jan Van den Bossche, Arjan W Griffioen, Elisabeth J M Huijbers. https://www.sciencedirect.com/science/article/pii/S0304419X20301463?via%3Dihub

Metabolic compartmentalization at the leading edge of metastatic cancer cells – Kara Wolfe, Ryo Kamata, Kester Coutinho, Takanari Inoue and Atsuo T. Sasaki. https://www.frontiersin.org/articles/10.3389/fonc.2020.554272/abstract

Targeting the HIF2–VEGF axis in renal cell carcinoma – Toni K. Choueiri and William G. Kaelin Jr. https://www.nature.com/articles/s41591-020-1093-z

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity – Emma U. Hammarlund, Emily Flashman, Sofie Mohlin, Francesco Licausi. https://science.sciencemag.org/content/370/6515/eaba3512

Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies – Ruiyuan Xu, Jinshou Yang, Bo Ren, Huanyu Wang, Gang Yang, Yuan Chen, Lei You, and Yupei Zhao. https://www.frontiersin.org/articles/10.3389/fonc.2020.572722/full

Multifaceted role of branched-chain amino acid metabolism in cancer – Hui Peng, Yingfei Wang and Weibo Luo. https://www.nature.com/articles/s41388-020-01480-z

Metabolic rivalry: circadian homeostasis and tumorigenesis – Kenichiro Kinouchi and Paolo Sassone-Corsi. https://www.nature.com/articles/s41568-020-0291-9

Targeting EMT in Cancer with Repurposed Metabolic Inhibitors – Vignesh Ramesh, Thomas Brabletz, Paolo Ceppi. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30189-8

Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer – Zhaodong Ji, Yan Shen, Xu Feng, Yue Kong, Yang Shao, Jiao Meng, Xiaofei Zhang, and Gong Yang. https://www.frontiersin.org/articles/10.3389/fonc.2020.593017/full

Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function – Ariel Igal, Débora I.Sinner. https://www.sciencedirect.com/science/article/abs/pii/S1388198120302328

Editorial: Metabolic Plasticity of Cancer – Sara Rodríguez-Enríquez, Tuuli Kaambre, and Rafael Moreno-Sánchez. https://www.frontiersin.org/articles/10.3389/fonc.2020.607511/full

Editorial: Metabolism Meets Function: Untangling the Cross-Talk Between Signaling and Metabolism – Alessandra Castegna, Daniel W. McVicar, Paolo E. Porporato, Annalisa Campanella, Erika M. Palmieri, and Alessio Menga. https://www.frontiersin.org/articles/10.3389/fonc.2020.607511/full

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer – Ellen C. de Heer, Mathilde Jalving, and Adrian L. Harris. https://www.jci.org/articles/view/137552

Quantitative Fluxomics of Circulating Metabolites – Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa, Xiaoxuan Li, Caroline Bartman, Zhaoyue Zhang, Cholsoon Jang, Lin Wang, Wenyun Lu, Jennifer Rojas, Joseph Baur, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30371-5

TCA cycle signalling and the evolution of eukaryotes – Dylan G Ryan, Christian Frezza, Luke AJ O’Neill. https://www.sciencedirect.com/science/article/abs/pii/S0958166920301440


Comments


Free Asparagine or Die: Cancer Cells Require Proteasomal Protein Breakdown to Survive Asparagine Depletion – Kristian Davidsen and Lucas B. Sullivan. https://cancerdiscovery.aacrjournals.org/content/10/11/1632

The smell of death and deCYStiny: polyamines play the hero – Joseph A. Combs and Gina M. DeNicola. https://www.nature.com/articles/s42255-020-0260-3

Hitting Gliomas When They Are Down: Exploiting IDH-Mutant Metabolic Vulnerabilities – Christopher J. Pirozzi and Hai Yan. https://cancerdiscovery.aacrjournals.org/content/10/11/1629

Metabolic ageing drives tumour progression – Ulrike Harjes. https://www.nature.com/articles/s41568-020-00301-5

Immortalizing switch to OXPHOS – Paulina Strzyz. https://www.nature.com/articles/s41580-020-00301-1

Serine Restriction Alters Sphingolipid Synthesis to Lower Tumor Growth. https://cancerdiscovery.aacrjournals.org/content/10/10/1440.2

Relapse-Driving AML Cells Exhibit Pyrimidine-Synthesis Dependency. https://cancerdiscovery.aacrjournals.org/content/10/10/1438.2

Fasting May Complement Endocrine Therapy. https://cancerdiscovery.aacrjournals.org/content/10/11/1617.2

Tumor Cells Deplete Methionine via SLC43A2, Causing T-cell Dysfunction. https://cancerdiscovery.aacrjournals.org/content/10/11/1623.2

Metabolic Adaptation to Lymphoma Suppresses NK-Cell Antitumor Function. https://cancerdiscovery.aacrjournals.org/content/10/11/1621.2


Paolo Sassone-Corsi (1956–2020) – Eric Verdin. https://science.sciencemag.org/content/370/6516/532

Paolo Sassone-Corsi (1956–2020) – Selma Masri, Colin R. Goding, Todd Leff. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30481-2

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