MetaboList – November 2020


Starvation/metabolism and translation


Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer – Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schneider, Michael E. Pacold, Alec C. Kimmelman. https://www.cell.com/cell/fulltext/S0092-8674(20)31322-2

Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors – Stefan Bresson, Vadim Shchepachev, Christos Spanos, Tomasz W. Turowski, Juri Rappsilber, David Tollervey. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30651-1

A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress – Adam M. Lamper, Rebecca H. Fleming, Kayla M. Ladd, Amy S. Y. Lee. https://science.sciencemag.org/content/370/6518/853

A translational program that suppresses metabolism to shield the genome – Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz and Stephen Lee. https://www.nature.com/articles/s41467-020-19602-2

eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis – Ruan H, Li X, Xu X, Leibowitz BJ, Tong J, Chen L, Ao L, Xing W, Luo J, Yu Y, Schoen RE, Sonenberg N, Lu X, Zhang L, Yu J. https://elifesciences.org/articles/60151

4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs – Khawla Alasad, Kai Voeltzke, Liron Levin, Guido Reifenberger, Gabriel Leprivier and Barak Rotblat. https://www.nature.com/articles/s41419-020-03182-6


Amino acid metabolism


Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway – Ian J. Restall, Orsolya Cseh, Laura M. Richards, Trevor J. Pugh, H. Artee Luchman and Samuel Weiss. https://cancerres.aacrjournals.org/content/early/2020/10/24/0008-5472.CAN-19-3923.long

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis – Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler and Juliane G. Bogner-Strauss. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00232-7

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity – Amani Bouzidi, Maria Chiara Magnifico, Alessandro Paiardini, Alberto Macone, Giovanna Boumis, Giorgio Giardina, Serena Rinaldo, Francesca Romana Liberati, Clotilde Lauro, Cristina Limatola, Chiara Lanzillotta, Antonella Tramutola, Marzia Perluigi, Gianluca Sgarbi, Giancarlo Solaini, Alessandra Baracca, Alessio Paone and Francesca Cutruzzolà. https://www.nature.com/articles/s41419-020-03215-0

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers – Yiqing Zhao, Xiujing Feng, Yicheng Chen, J. Eva Selfridge, Shashank Gorityala, Zhanwen Du, Janet M. Wang, Yujun Hao, Gino Cioffi, Ronald A. Conlon, Jill S. Barnholtz-Sloan, Joel Saltzman, Smitha S. Krishnamurthi, Shaveta Vinayak, Martina Veigl, Yan Xu, David L. Bajor, Sanford D. Markowitz, Neal J. Meropol, Jennifer R. Eads and Zhenghe Wang. https://cancerres.aacrjournals.org/content/80/21/4815


Glycolysis, glucosamines


The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer – Jiyeon Kim, Hyun Min Lee, Feng Cai, Bookyung Ko, Chendong Yang, Elizabeth L. Lieu, Nefertiti Muhammad, Shawn Rhyne, Kailong Li, Mohamed Haloul, Wen Gu, Brandon Faubert, Akash K. Kaushik, Ling Cai, Sahba Kasiri, Ummay Marriam, Kien Nham, Luc Girard, Hui Wang, Xiankai Sun, James Kim, John D. Minna, Keziban Unsal-Kacmaz and Ralph J. DeBerardinis. https://www.nature.com/articles/s42255-020-00316-0

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers – Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Victoria C. Yan, Yasaman Barekatain, Sunada Khadka, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Cong-Dat Pham, Kenisha Arthur, David Maxwell, Zhenghong Peng, Paul G. Leonard, Barbara Czako, Federica Pisaneschi, Pijus Mandal, Yuting Sun, Rafal Zielinski, Susana Castro Pando, Xiaobo Wang, Theresa Tran, Quanyu Xu, Qi Wu, Yongying Jiang, Zhijun Kang, John M. Asara, Waldemar Priebe, William Bornmann, Joseph R. Marszalek, Ronald A. DePinho and Florian L. Muller. https://www.nature.com/articles/s42255-020-00313-3

Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target – Juliana C. Ferreira, Abdul-Rahman Khrbtli, Cameron Lee Shetler, Samman Mansoor, Liaqat Ali, Ozge Sensoy and Wael M. Rabeh. http://www.jbc.org/content/early/2020/11/13/jbc.RA120.015293.abstract

Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis – Keqiu Jiang, Chengyong Dong, Zeli Yin, Rui Li, Jiakai Mao, Chengye Wang, Junlin Zhang, Zhenming Gao, Rui Liang, Qi Wang and Liming Wang. https://www.nature.com/articles/s41419-020-03179-1


Lipid metabolism


Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis – Jonathan S. Rink, Adam Lin, Kaylin M. McMahon, Andrea E Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton and Leo I Gordon. http://www.jbc.org/content/early/2020/11/18/jbc.RA120.014888.abstract

ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway – Guohua Chen, Guoli Zhou, Aaron Lotvola, James G. Granneman and Jian Wang. http://www.jbc.org/content/early/2020/11/20/jbc.RA120.014682.abstract

The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial – Maria Feldt, Julien Menard, Ann H. Rosendahl, Barbara Lettiero, Pär-Ola Bendahl, Mattias Belting and Signe Borgquist. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00231-8


Mitochondria and mitochondrial stress


MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity – Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa and Masatoshi Nomura. https://www.nature.com/articles/s41467-020-19287-7

Anti-cancer strategy targeting the energy metabolism of tumor cells surviving a low-nutrient acidic microenvironment – Yuki Maeda, Ryota Kikuchi, Junichiro Kawagoe, Takao Tsuji, Nobuyuki Koyama, Kazuhiro Yamaguchi, Hiroyuki Nakamura, Kazutetsu Aoshiba. https://www.sciencedirect.com/science/article/pii/S2212877820301678


Starvation / nutrient sensing


Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation – Chan Lee, Lilian Lamech, Eleanor Johns, Michael Overholtzer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30666-3

Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress – Huaiyuan Zhang, Yu Zhao, Qi Yao, Zijing Ye, Adriana Mañas, Jialing Xiang. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242700

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity – Yao Yao, Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A. MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30687-0

Rapid changes in the ATG5‐ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT) – Emily Crowley  Euphemia Leung  Jóhannes Reynisson  Alan Richardson. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15275


mTOR / AMPK


The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction – Shu Yang, Yingbiao Zhang, Chun-Yuan Ting, Lucia Bettedi, Kuikwon Kim, Elena Ghaniam, Mary A. Lilly. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30630-4

IQGAP1 binds AMPK and is required for maximum AMPK activation – Andrew C. Hedman, Zhigang Li, Laëtitia Gorisse, Swetha Parvathaneni, Chase J. Morgan and David B. Sacks. http://www.jbc.org/content/early/2020/11/15/jbc.RA120.016193.abstract


Hypoxia


p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen – Liz J. Valente; Amy Tarangelo; Albert Mao Li ; Marwan Naciri; Nitin Raj; Anthony M. Boutelle; Yang Li; Stephano Spano Mello ; Kathryn Bieging-Rolett; Ralph J. DeBerardinis; Jiangbin Ye; Scott J. Dixon; Laura D. Attardi. https://rupress.org/jcb/article/219/11/e201908212/152074

LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α – Linguo Xu, Lin Huan, Tianan Guo, Yangjun Wu, Yanfang Liu, Qifeng Wang, Shenglin Huang, Ye Xu, Linhui Liang and Xianghuo He. https://www.nature.com/articles/s41388-020-01512-8


Cancer Immunometabolism


Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity – Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30722-X

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy – Meixi Hao, Siyuan Hou, Weishuo Li, Kaiming Li, Lingjing Xue, Qifan Hu, Lulu Zhu, Yue Chen, Hongbin Sun, Caoyun Ju, Can Zhang. https://stm.sciencemag.org/content/12/571/eaaz6667

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy – Chia-Sing Lu, Ching-Wen Lin, Ya-Hsuan Chang, Hsuan-Yu Chen, Wei-Chia Chung2, Wei-Yun Lai, Chao-Chi Ho, Tong-Hong Wang, Chi-Yuan Chen, Chen-Lin Yeh, Sean Wu, Shu-Ping Wang and Pan-Chyr Yang. https://jitc.bmj.com/content/8/2/e001392


Miscellaneous


Treatment of glioblastoma multiforme with “classic” 4:1 ketogenic diet total meal replacement – Pavel Klein, Ivana Tyrlikova, Giulio Zuccoli, Adam Tyrlik and Joseph C. Maroon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00230-9

Downregulation of Keap1 Confers Features of a Fasted Metabolic State – Elena V Knatko, Michael H Tatham, Ying Zhang, Cecilia Castro, Maureen Higgins, Sharadha Dayalan Naidu, Chiara Leonardi, Laureano de la Vega, Tadashi Honda, Julian L Griffin, Ronald T Hay, Albena T Dinkova-Kostova. https://www.cell.com/iscience/fulltext/S2589-0042(20)30830-0


Reviews


Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy – Weimin Wang, Weiping Zou. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30614-6

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer – DeBlasi JM, DeNicola GM. https://pubmed.ncbi.nlm.nih.gov/33080927/

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment – Lara P. Fernández, Marta Gómez de Cedrón, and Ana Ramírez de Molina. https://www.frontiersin.org/articles/10.3389/fonc.2020.577420/full

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation – Tashbib Khan, Mitchell A. Sullivan, Jennifer H. Gunter, Thomas Kryza, Nicholas Lyons, Yaowu He, and John D. Hooper. https://www.frontiersin.org/articles/10.3389/fonc.2020.592455/full

Metabolic heterogeneity in cancer: An overview and therapeutic implications – Yu Tong, Wei-Qiang Gao, Yanfeng Liu. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20301402

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors – Marjolein M.G. Kes, Jan Van den Bossche, Arjan W. Griffioen, Elisabeth J.M. Huijbers. https://www.sciencedirect.com/science/article/pii/S0304419X20301463

2-Oxoglutarate-dependent dioxygenases in cancer – Julie-Aurore Losman, Peppi Koivunen and William G. Kaelin Jr. https://www.nature.com/articles/s41568-020-00303-3

A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer – Kodama M, Nakayama KI.. https://onlinelibrary.wiley.com/doi/10.1002/bies.202000169

Current biomarker-associated procedures of cancer modeling-a reference in the context of IDH1 mutant glioma – Narges Zare Mehrjardi, Daniel Hänggi and Ulf Dietrich Kahlert. https://www.nature.com/articles/s41419-020-03196-0

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy – Michaël Cerezo and Stéphane Rocchi. https://www.nature.com/articles/s41419-020-03175-5


Comments


A Tug-of-War Over Methionine – Ke Xu, Amy Shyu, Ming O. Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30549-0

Aldolase deployed for surveilling glucose – Sheng-Cai Lin. https://www.nature.com/articles/s41580-020-00305-x

Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux – Maria I. Matias, Valérie Dardalhon, Naomi Taylor. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30783-8

The metabolic foibles of triple negative breast cancer – Emily J. Gallagher. https://stm.sciencemag.org/content/12/571/eabf7102

In PDAC, “bad” cholesterol is good – Leslie K. Ferrarelli. https://stke.sciencemag.org/content/13/657/eabf5642

Metabolic benefits of mitochondrial DNA mutations – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-00309-x

Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming – Ana M.Urbano. https://www.sciencedirect.com/science/article/pii/S0925443920303136

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The 4th edition of Cancer and Metabolism symposium – Bordeaux area, France, May 27-29th 2021 will address key questions on human tumors nutrition and metabolism. Special guest: Sir Peter J. Ratcliffe, Nobel co-Laureate in 2019. http://www.canceropole-gso.org/?p=calendrier&id=1905&mod=evenement_consulter

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For more weekly updates on papers on Glutamine metabolism follow  Sreeparna Banerjee (https://twitter.com/sreeparna_b)

For more weekly papers on mitochondrial bioenergetics and cancer follow Kelsey Fisher-Wellman (https://twitter.com/KFW_Lab) (and @Frezzalab of course)

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