MetaboList – January 2021


Metabolic pathways (general) and cancer


Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets – Yue Gong, Peng Ji, Yun-Song Yang, Xin Hu, Yi-Zhou Jiang, Zhi-Ming Shao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30545-3

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer – Douglas E. Biancur, Kevin S. Kapner, Keisuke Yamamoto, Robert S. Banh, Jasper E. Neggers, Albert S.W. Sohn, Warren Wu, Robert T. Manguso, Adam Brown, David E. Root, Andrew J. Aguirre, Alec C. Kimmelman. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30551-9

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells – Xiphias Ge Zhu, Aleksey Chudnovskiy, Lou Baudrier, Benjamin Prizer, Yuyang Liu, Benjamin N. Ostendorf, Norihiro Yamaguchi, Abolfozl Arab, Bernardo Tavora, Rebecca Timson, Søren Heissel, Elisa de Stanchina, Henrik Molina, Gabriel D. Victora, Hani Goodarzi, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30550-7

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma – James Reigle, Dina Secic, Jacek Biesiada, Collin Wetzel, Behrouz Shamsaei, Johnson Chu, Yuanwei Zang, Xiang Zhang, Nicholas J. Talbot, Megan E. Bischoff, Yongzhen Zhang, Charuhas V. Thakar, Krishnanath Gaitonde, Abhinav Sidana, Hai Bui, John T. Cunningham, Qing Zhang, Laura S. Schmidt, W. Marston Linehan, Mario Medvedovic, David R. Plas, Julio A. Landero Figueroa, Jarek Meller, and Maria F. Czyzyk-Krzeska. https://www.jci.org/articles/view/140522

Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes – Karl Kochanowski, Timur Sander, Hannes Link, Jeremy Chang, Steven J. Altschuler, Lani F. Wu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31636-3

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors – Anna Han, Timothy J. Purwin, Nelisa Bechtel, Connie Liao, Vivian Chua, Erin Seifert, Takami Sato, Zachary T. Schug, David W. Speicher, J. William Harbour and Andrew E. Aplin. https://www.nature.com/articles/s41388-020-01554-y

Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI – Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen and May-Britt Tessem. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00242-z


Hexose metabolism


Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer – Catríona M. Dowling , Kate E. R. Hollinshead, Alessandra Di Grande, Justin Pritchard, Hua Zhang, Eugene T. Dillon, Kathryn Haley, Eleni Papadopoulos, Anita K. Mehta, Rachel Bleach, Andreas U. Lindner, Brian Mooney, Heiko Düssmann, Darran O’Connor, Jochen H. M. Prehn, Kieran Wynne, Michael Hemann, James E. Bradner, Alec C. Kimmelman, Jennifer L. Guerriero, Gerard Cagney, Kwok-Kin Wong, Anthony G. Letai, Tríona Ní Chonghaile. https://advances.sciencemag.org/content/7/3/eabc4897

The harsh microenvironment in early breast cancer selects for a Warburg phenotype – Mehdi Damaghi, Jeffrey West, Mark Robertson-Tessi, Liping Xu, Meghan C. Ferrall-Fairbanks, Paul A. Stewart, Erez Persi, Brooke L. Fridley, Philipp M. Altrock, Robert A. Gatenby, Peter A. Sims, Alexander R. A. Anderson, and Robert J. Gillies. https://www.pnas.org/content/118/3/e2011342118.abstract?etoc

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex – Xuxiao He, Min Li, Hongming Yu, Guijun Liu, Ningning Wang, Chunzhao Yin, Qiaochu Tu, Goutham Narla, Yongzhen Tao, Shuqun Cheng, Huiyong Yin. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000803

Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells – Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem and Stefan Wölfl. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00239-8

Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment – Yongbo Yu, Ye Liang, Dan Li, Liping Wang, Zhijuan Liang, Yuanbin Chen, Guofeng Ma, Hui Wu, Wei Jiao and Haitao Niu. https://www.nature.com/articles/s41420-021-00401-7

Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with localized primary gastrointestinal stromal tumors – Sang Hyun Hwang, Minkyu Jung, Yong Hyu Jeong, KwanHyeong Jo, Soyoung Kim, Jiyoung Wang and Arthur Cho. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00244-x

Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells – Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman and P. Darrell Neufer. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00241-0


Lactate


An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism – Nunu Huang, Fanying Li, Maolei Zhang, Huangkai Zhou, Zhipeng Chen, Xiaoyan Ma, Lixuan Yang, Xujia Wu, Jian Zhong, Feizhe Xiao, Xuesong Yang, Kun Zhao, Xixi Li, Xin Xia, Zexian Liu, Song Gao, Nu Zhang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30663-X

Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export – Ke Wang, Wan Huang, Ruo Chen, Peng Lin, Tao Zhang, Yun-Feng Ni, Hao Li, Jiao Wu, Xiu-Xuan Sun, Jie-Jie Geng, Yu-Meng Zhu, Gang Nan, Wei Zhang, Xi Chen, Ping Zhu, Huijie Bian, Zhi-Nan Chen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30660-4

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates – Nan Wang, Xin Jiang, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan. https://www.cell.com/cell/fulltext/S0092-8674(20)31615-9


Amino acid metabolism


The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer – Arafath K. Najumudeen, Fatih Ceteci, Sigrid K. Fey, Gregory Hamm, Rory T. Steven, Holly Hall, Chelsea J. Nikula, Alex Dexter, Teresa Murta, Alan M. Race, David Sumpton, Nikola Vlahov, David M. Gay, John R. P. Knight, Rene Jackstadt, Joshua D. G. Leach, Rachel A. Ridgway, Emma R. Johnson, Colin Nixon, Ann Hedley, Kathryn Gilroy, William Clark, Sudhir B. Malla, Philip D. Dunne, Giovanny Rodriguez-Blanco, Susan E. Critchlow, Agata Mrowinska, Gaurav Malviya, Dmitry Solovyev, Gavin Brown, David Y. Lewis, Gillian M. Mackay, Douglas Strathdee, Saverio Tardito, Eyal Gottlieb, CRUK Rosetta Grand Challenge Consortium, Zoltan Takats, Simon T. Barry, Richard J. A. Goodwin, Josephine Bunch, Martin Bushell, Andrew D. Campbell and Owen J. Sansom. https://www.nature.com/articles/s41588-020-00753-3

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy – Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom and Karen H. Vousden. https://www.nature.com/articles/s41467-020-20223-y

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis – Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S. Harris, Gina M. DeNicola. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30662-8

Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma – Richa Rathore, Katharine E. Caldwell, Charles Schutt, Caitlyn B. Brashears, Bethany C. Prudner, William R. Ehrhardt, Cheuk Hong Leung, Heather Lin, Najat C. Daw, Hannah C. Beird, Abigail Giles, Wei-Lien Wang, Alexander J. Lazar, John S.A. Chrisinger, J. Andrew Livingston, Brian A. Van Tine. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31667-3

Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer – Deanna N. Edwards, Verra M. Ngwa, Ariel L. Raybuck, Shan Wang, Yoonha Hwang, Laura C. Kim, Sung Hoon Cho, Yeeun Paik, Qingfei Wang, Siyuan Zhang, H. Charles Manning, Jeffrey C. Rathmell, Rebecca S. Cook, Mark R. Boothby, Jin Chen. https://www.jci.org/articles/view/140100

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells – Sangmoo Jeong, Angela Maria Savino, Rachel Chirayil, Ersilia Barin, Yuanming Cheng, Sun-Mi Park, Alexandra Schurer, Edouard Mullarky, Lewis C. Cantley, Michael G. Kharas, Kayvan R. Keshari. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30665-3

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells – Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S. https://www.mdpi.com/2072-6694/13/3/412

Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells – Leonard C. Rogers, Jing Zhou, Adriana Baker, Charles R. Schutt, Prashanta K. Panda and Brian A. Van Tine. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00238-9


Lipid metabolism


Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas – Nivea Dias Amoedo, Saharnaz Sarlak, Emilie Obre, Pauline Esteves, Hugues Bégueret, Yann Kieffer, Benoît Rousseau, Alexis Dupis, Julien Izotte, Nadège Bellance, Laetitia Dard, Isabelle Redonnet-Vernhet, Giuseppe Punzi, Mariana Figueiredo Rodrigues, Elodie Dumon, Walid Mafhouf, Véronique Guyonnet-Dupérat, Lara Gales, Tony Palama, Floriant Bellvert, Nathalie Dugot-Senan, Stéphane Claverol, Jean-Marc Baste, Didier Lacombe, Hamid Reza Rezvani, Ciro Leonardo Pierri, Fatima Mechta-Grigoriou, Matthieu Thumerel, and Rodrigue Rossignol. https://www.jci.org/articles/view/133081

Phospholipid dynamics in ex vivo lung cancer and normal lung explants – Julia Lesko, Alexander Triebl, Elvira Stacher-Priehse, Nicole Fink-Neuböck, Jörg Lindenmann, Freyja-Maria Smolle-Jüttner, Harald C. Köfeler, Andelko Hrzenjak, Horst Olschewski & Katharina Leithner. https://www.nature.com/articles/s12276-020-00547-x

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma – Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E. Davis, Pei Lin, P. Leif Bergsagel, Elisabet E. Manasanch, Stephen T.C. Wong, Nestor F. Esnaola, Jenny C. Chang, Robert Z. Orlowski, Qing Yi, Jing Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30666-5

A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer – Krishna B. Singh, Eun-Ryeong Hahm, Su-Hyeong Kim, Stacy G. Wendell and Shivendra V. Singh. https://www.nature.com/articles/s41388-020-01553-z

2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis – Liang Sun, Xiaoqin Yang, Xiaoheng Huang, Yizhou Yao, Xiangyu Wei, Shugao Yang, Diyuan Zhou, Wei Zhang, Zhimin Long, Xiaoyan Xu, Xinguo Zhu, Songbing He and Xiong Su. https://cancerres.aacrjournals.org/content/81/2/289

Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation – Qingyu Zhang, Wei Zhou, Shan Yu, Yaojun Ju, Sally Kit Yan To, Alice Sze Tsai Wong, Yufei Jiao, Terence Chuen Wai Poon, Kin Yip Tam and Leo Tsz On Lee. https://www.nature.com/articles/s41388-020-01516-4


Nucleotides and NADPH


Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation – Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M. Ghergurovich, Lili Guo, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30535-0

Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model – Martin P. Ogrodzinski, Shao Thing Teoh and Sophia Y. Lunt. https://cancerres.aacrjournals.org/content/81/2/303

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer – Fang Huang, Kenneth E. Huffman, Zixi Wang, Xun Wang, Kailong Li, Feng Cai, Chendong Yang, Ling Cai, Terry S. Shih, Lauren G. Zacharias, Andrew Chung, Qian Yang, Milind D. Chalishazar, Abbie S. Ireland, C. Allison Stewart, Kasey Cargill, Luc Girard, Yi Liu, Min Ni, Jian Xu, Xudong Wu, Hao Zhu, Benjamin Drapkin, Lauren A. Byers, Trudy G. Oliver, Adi F. Gazdar, John D. Minna, and Ralph J. DeBerardinis. https://www.jci.org/articles/view/139929

NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor comple – Wei Li, Junjie Kou, Junying Qin, Li Li, Zhenxi Zhang, Ying Pan, Yi Xue and Wenjing Du. https://www.nature.com/articles/s42255-020-00330-2


Mitochondrial metabolism


Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer – Daniel R. Crooks , Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, G. Mariah Cawthon, Ferri Sohelian, Natalia De Val, Ruth M. Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa W.-M. Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa, Ashkan A. Malayeri, Maria J. Merino, Youfeng Yang, Jordan L. Meier, Mark W. Ball, Tracey A. Rouault, Ramaprasad Srinivasan, W. Marston Linehan. https://stke.sciencemag.org/content/14/664/eabc4436

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice – Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera & Alessio Nencioni. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00240-1

Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer – Bianca Oresta , Chiara Pozzi, Daniele Braga, Rodolfo Hurle, Massimo Lazzeri, Piergiuseppe Colombo, Nicola Frego, Marco Erreni, Cristina Faccani, Grazia Elefante, Matteo Barcella, Giorgio Guazzoni, Maria Rescigno. https://stm.sciencemag.org/content/13/575/eaba6110

Targeting oxidative phosphorylation to increase the efficacy of radio- and immune- combination therapy – Daan F Boreel, Paul N Span, Sandra Heskamp, Gosse J. Adema and Johan Bussink. https://clincancerres.aacrjournals.org/content/early/2021/01/08/1078-0432.CCR-20-3913


Mitochondrial stress


Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction – Kendall J. Condon, Jose M. Orozco, Charles H. Adelmann, Jessica B. Spinelli, Pim W. van der Helm, Justin M. Roberts, Tenzin Kunchok, and David M. Sabatini. https://www.pnas.org/content/118/4/e2022120118.abstract?etoc

Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response – Kai Mao, Peter Breen, Gary Ruvkun. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000996

Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress – Lingjie Sang, Huai-qiang Ju, Zuozhen Yang, Qiwei Ge, Zhen Zhang, Fangzhou Liu, Luojia Yang, Hangdi Gong, Chengyu Shi, Lei Qu, Hui Chen, Minjie Wu, Hao Chen, Ruihua Li, Qianqian Zhuang, Hailong Piao, Qingfeng Yan, Weishi Yu, Liangjing Wang, Jianzhong Shao, Jian Liu, Wenqi Wang, Tianhua Zhou and Aifu Lin. https://www.nature.com/articles/s42255-020-00325-z

Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration – Zhaoying Yang, Xiaocui Zhao, Weina Shang, Yang Liu, Jun-Feng Ji, Jun-Ping Liu and Chao Tong. https://www.nature.com/articles/s41418-020-0601-5

Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway – Lin Cheng, Xu Zhang, Yu-Zhou Huang, Yu-Lan Zhu, Ling-Yun Xu, Zhi Li, Xin-Yuan Dai, Liang Shi, Xu-Jie Zhou, Ji-Fu Wei and Qiang Ding. https://www.nature.com/articles/s41389-020-00290-y

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development – Zhida Wu, Meiling Zuo, Ling Zeng, Kaisa Cui, Bing Liu, Chaojun Yan, Li Chen, Jun Dong, Fugen Shangguan, Wanglai Hu, He He, Bin Lu, Zhiyin Song. https://www.embopress.org/doi/abs/10.15252/embr.202050827


Starvation response / ATF4


PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner – Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals and Jose C. Perales. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00236-3

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis – Kwontae You, Lingfei Wang, Chih-Hung Chou, Kai Liu, Toru Nakata, Alok Jaiswal, Junmei Yao, Ariel Lefkovith, Abdifatah Omar, Jacqueline G Perrigoue, Jennifer E Towne, Aviv Regev, Daniel B Graham, Ramnik J Xavier. https://science.sciencemag.org/content/371/6524/eabb6896

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program – Rajalakshmi Srinivasan, Adhish S. Walvekar, Zeenat Rashida, Aswin Seshasayee, Sunil Laxman. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009252

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B – Alisa F. Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P. Harding, Ana Crespillo-Casado, Luke A. Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30738-3


mTOR


Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation – Sung-Hoon Kim, Jung-Hyun Choi, Peng Wang, Christopher D. Go, Geoffrey G. Hesketh, Anne-Claude Gingras, Seyed Mehdi Jafarnejad, Nahum Sonenberg. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4

Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma – Liangfang Yao, Yang Xuan, Haiyang Zhang, Bo Yang, Xinglong Ma, Tianzhen Wang, Tianyuan Meng, Wenshe Sun, Haibin Wei, Xueqing Ma, Robb Moses, Jianru Xiao, Pei Zhang, Chao Ge, Jinjun Li, Lei Li, Xiaotao Li, Jinbao Li and Bianhong Zhang. https://www.nature.com/articles/s41388-020-01558-8


Hypoxia


Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation – Omar A. Itani, Xuefei Zhong, Xiaoting Tang, Barbara A. Scott, Jun Yi Yan, Stephane Flibotte, Yiting Lim, Andrew C. Hsieh, James E. Bruce, Marc Van Gilst, C. Michael Crowder. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31505-0

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis – Alina Küper, Jennifer Baumann, Kirsten Göpelt, Melanie Baumann, Christopher Sänger, Eric Metzen, Philip Kranz & Ulf Brockmeier. https://www.nature.com/articles/s41419-020-03319-7


Cancer Immunometabolism


Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion – Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk, Paolo D. A. Vignali, B. Rhodes Ford, Natalie L. Rittenhouse, Ronal Peralta, Yiyang Wang, Yupeng Wang, Kristin DePeaux, Amanda C. Poholek and Greg M. Delgoffe. https://www.nature.com/articles/s41590-020-00834-9

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion – Hongwei Lv, Guishuai Lv, Cian Chen, Qianni Zong, Guoqing Jiang, Dan Ye, Xiuliang Cui, Yufei He, Wei Xiang, Qin Han, Liang Tang, Wen Yang, Hongyang Wang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30554-4

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles – Zhaohan Wei, Xiaoqiong Zhang, Tuying Yong, Nana Bie, Guiting Zhan, Xin Li, Qingle Liang, Jianye Li, Jingjing Yu, Gang Huang, Yuchen Yan, Zelong Zhang, Bixiang Zhang, Lu Gan, Bo Huang and Xiangliang Yang. https://www.nature.com/articles/s41467-020-20723-x


Miscellaneous


Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death – Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta-Leonor Rodriguez, Marta Garcia-Cajide, Virginia Amador, Ramón Salazar, Sara C Kozma, Eric P Kusnadi, Jian Kang, Antonio Gentilella, Richard B Pearson, George Thomas, Joffrey Pelletier. https://ashpublications.org/blood/article/doi/10.1182/blood.2020007452/474958

Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia – Wenjun Hu, Hairong Xiong, Zeyuan Ru, Yan Zhao, Yali Zhou, Kairu Xie, Wen Xiao, Zhiyong Xiong, Cheng Wang, Changfei Yuan, Jian Shi, Quansheng Du, Xiaoping Zhang & Hongmei Yang. https://www.nature.com/articles/s41419-020-03382-0

IDH1 mutations induce organelle defects via dysregulated phospholipids – Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad & Mioara Larion. https://www.nature.com/articles/s41467-020-20752-6


Reviews


Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism – Ilaria Elia and Marcia C. Haigis. https://www.nature.com/articles/s42255-020-00317-z

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers – Gaurav Pathria, Ze’ev A. Ronai. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30664-1

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies – Daqian Xu, Fei Shao, Xueli Bian, Ying Meng, Tingbo Liang, Zhimin Lu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30670-7

Lipid metabolism and cancer – Xueli Bian; Rui Liu; Ying Meng; Dongming Xing; Daqian Xu; Zhimin Lu. https://rupress.org/jem/article-abstract/218/1/e20201606/211616/

Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies – Matthew S. Waitkus and Hai Yan. https://clincancerres.aacrjournals.org/content/27/2/383

Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification – Pilar Espiau-Romera, Sarah Courtois, Beatriz Parejo-Alonso, Patricia Sancho. https://www.mdpi.com/2077-0383/9/12/4128

The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells – Yoshida GJ. https://pubmed.ncbi.nlm.nih.gov/33401672/

Modification of Proteins by Metabolites in Immunity – Diskin, T.A.J. Ryan, L.A.J. O’Neill. https://www.cell.com/immunity/fulltext/S1074-7613(20)30408-8

Immunometabolic Interplay in the Tumor Microenvironment – Irem Kaymak, Kelsey S. Williams, Jason R. Cantor, Russell G. Jones. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30478-5

The diversity and breadth of cancer cell fatty acid metabolism – Shilpa R. Nagarajan, Lisa M. Butler and Andrew J. Hoy. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00237-2

Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts – Weber DD, Thapa M, Aminzadeh-Gohari S, Redtenbacher AS, Catalano L, Feichtinger RG, Koelblinger P, Dallmann G, Emberger M, Kofler B, Lang R.. https://pubmed.ncbi.nlm.nih.gov/33498757/

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia – Valentina Rausch, Valentina Sala, Fabio Penna, Paolo Ettore Porporato & Alessandra Ghigo. https://www.nature.com/articles/s41389-020-00288-6

The ins and outs of serine and glycine metabolism in cancer – Shauni L. Geeraerts, Elien Heylen, Kim De Keersmaecker & Kim R. Kampen. https://www.nature.com/articles/s42255-020-00329-9

Endoplasmic reticulum stress signals in the tumour and its microenvironment – Xi Chen & Juan R. Cubillos-Ruiz. https://www.nature.com/articles/s41568-020-00312-2


Comments


Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target  – Sanne Bootsma, Sanne M. van Neerven and Louis Vermeulen. https://www.nature.com/articles/s41588-020-00758-y

Food for Growth: Distinct Nutrient Preferences between Primary Tumors and Metastases – Yannick Audet-Delage, Julie St-Pierre. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30965-5

From the T-cell receptor to cancer therapy: an interview with Tak W. Mak – Tak W. Mak. https://www.nature.com/articles/s41418-020-00666-y

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s