MetaboList – April 2021


Cancer Immunometabolism


Cell-programmed nutrient partitioning in the tumour microenvironment – Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson, Ayaka Sugiura, Allison S. Cohen, Ahmed Ali, Brian T. Do, Alexander Muir, Caroline A. Lewis, Rachel A. Hongo, Kirsten L. Young, Rachel E. Brown, Vera M. Todd, Tessa Huffstater, Abin Abraham, Richard T. O’Neil, Matthew H. Wilson, Fuxue Xin, M. Noor Tantawy, W. David Merryman, Rachelle W. Johnson, Christopher S. Williams, Emily F. Mason, Frank M. Mason, Katherine E. Beckermann, Matthew G. Vander Heiden, H. Charles Manning, Jeffrey C. Rathmell and W. Kimryn Rathmell. https://www.nature.com/articles/s41586-021-03442-1

Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity – Yiwen Zhang, Hongrong Hu, Weiwei Liu,Shu-Mei Yan3, Yuzhuang Li, Likai Tan, Yingshi Chen, Jun Liu, Zhilin Peng, Yaochang Yuan, Wenjing Huang, Fei Yu, Xin He, Bo Li, Hui Zhang. https://jitc.bmj.com/content/9/4/e002137


Glucose metabolism


The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts – Junjie Gu, Xuechun Li, Lin Zhao, Ying Yang, Chunling Xue, Yang Gao, Jing Li, Qin Han, Zhao Sun, Chunmei Bai and Robert Chunhua Zhao. https://www.nature.com/articles/s41419-021-03579-x

BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells – Calder W. Reinsborough, Hélène Ipas, Nathan S. Abell, Ellen B. Gouws, J. Paige Williams, Marvin Mercado, Carla Van Den Berg and Blerta Xhemalçe. https://www.nature.com/articles/s41388-021-01702-y

Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response – Hayato Irokawa; Satoshi Numasaki; Shin Kato; Kenta Iwai; Atsushi Inose-Maruyama; Takumi Ohdate; Gi-Wook Hwang; Takashi Toyama; Toshihiko Watanabe; Shusuke Kuge. https://portlandpress.com/biochemj/article-abstract/478/7/1453/228124

DOWN REGULATION OF LACTATE DEHYDROGENASE INITIATES APOPTOSIS IN HELA AND MCF-7 CANCER CELLS THROUGH INCREASED VOLTAGE-DEPENDENT ANION CHANNEL PROTEIN AND INHIBITION OF BCL2 – Suhail Al-Salam, Karthishwaran Kandhan,  and  Manjusha Sudhadevi. https://www.oncotarget.com/article/27950/text/

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation – Anxo Martínez-Ordoñez, Samuel Seoane, Leandro Avila, Noemi Eiro, Manuel Macía, Efigenia Arias, Fabio Pereira, Tomas García-Caballero, Noemi Gómez-Lado, Pablo Aguiar, Francisco Vizoso and Román Perez-Fernandez. https://www.nature.com/articles/s41388-021-01740-6

The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells – Wenwen Gao, Mengqiu Huang, Xi Chen, Jianping Chen, Zhiwei Zou, Linlin Li, Kaiyuan Ji, Zhirui Nie, Bingsheng Yang, Zibo Wei, Pengfei Xu, Junshuang Jia, Qianbing Zhang, Hongfen Shen, Qianli Wang, Keyi Li, Lingqun Zhu, Meng Wang, Shuangyan Ye, Sisi Zeng, Ying Lin, Zhili Rong, Yang Xu, Peng Zhu, Hui Zhang, Bingtao Hao and Qiuzhen Liu. https://www.nature.com/articles/s41419-021-03681-0

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation – Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, and Ni Tang. https://www.jci.org/articles/view/144703

HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness – Lei Bi, Yidan Ren, Maoxiao Feng, Peng Meng, Qin Wang, Weiping Chen, Qinlian Jiao, Yuli Wang, Lutao Du, Fuqiong Zhou, Yucui Jiang, Feiyan Chen, Chuanxin Wang, Bo Tang and Yunshan Wang. https://cancerres.aacrjournals.org/content/81/8/2015


Amino acids and glycosamines


Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells – Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen and Hsing-Jien Kung. https://www.nature.com/articles/s41467-021-22652-9

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 – Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann and Martin S. Denzel. https://www.nature.com/articles/s41467-021-22320-y


Lipid metabolism


Fatty acid synthesis is required for breast cancer brain metastasis – Gino B. Ferraro, Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott, Divya Bezwada, Landry Blanc, Brendan Prideaux, Xin Jin, Jessica M. Possada, Jiang Chen, Christopher R. Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy X. Chen, Kamila Naxerova, Christopher Ng, Anna M. Westermark, Mark Duquette, Sylvie Roberge, Neal I. Lindeman, Costas A. Lyssiotis, Jens Nielsen, David E. Housman, Dan G. Duda, Elena Brachtel, Todd R. Golub, Lewis C. Cantley, John M. Asara, Shawn M. Davidson, Dai Fukumura, Véronique A. Dartois, Clary B. Clish, Rakesh K. Jain and Matthew G. Vander Heiden. https://www.nature.com/articles/s43018-021-00183-y

Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis – Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G. P. Grünewald, Adrian Liston, Chantal Mathieu, Christophe M. Deroose, Johannes V. Swinnen, Diether Lambrechts, Diego di Bernardo, Shinya Kuroda, Katrien De Bock and Sarah-Maria Fendt. https://cancerres.aacrjournals.org/content/early/2021/03/04/0008-5472.CAN-20-1954

Down-regulation of SLC25A20 promotes hepatocellular carcinoma growth and metastasis through suppression of fatty-acid oxidation – Peng Yuan, Jiao Mu, Zijun Wang, Shuaijun Ma, Xiuwei Da, Jian Song, Hongxin Zhang, Le Yang, Jibin Li and Jingyue Yang. https://www.nature.com/articles/s41419-021-03648-1


Nucleotides and NAD(P)


Mitochondrial NADP+ is essential for proline biosynthesis during cell growth – Diem H. Tran, Rushendhiran Kesavan, Halie Rion, Mona Hoseini Soflaee, Ashley Solmonson, Divya Bezwada, Hieu S. Vu, Feng Cai, John A. Phillips III, Ralph J. DeBerardinis and Gerta Hoxhaj. https://www.nature.com/articles/s42255-021-00374-y

Mitochondrial NADP(H) generation is essential for proline biosynthesis – Jiajun Zhu, Simon Schwörer, Mirela Berisa, Yeon Ju Kyung,Keun Woo Ryu, Junmei Yi, Xuejun Jiang, Justin R. Cross, Craig B. Thompson. https://science.sciencemag.org/content/early/2021/04/21/science.abd5491

Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer – Craig Davison, Roisin Morelli, Catherine Knowlson, Melanie McKechnie, Robbie Carson, Xanthi Stachtea, Kylie A. McLaughlin, Vivien E. Prise, Kienan Savage, Richard H. Wilson, Karl A. Mulligan, Peter M. Wilson, Robert D. Ladner and Melissa J. LaBonte. https://www.nature.com/articles/s41523-021-00245-5


Mitochondria


PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer – Laura C. A. Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian MacKay, David Sumpton, Owen J. Sansom, Hing Y. Leung and Imran Ahmad. https://www.nature.com/articles/s41388-021-01707-7

Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth – Denise Sighel, Michela Notarangelo, Shintaro Aibara, Angela Re, Gianluca Ricci, Marianna Guida, Alessia Soldano, Valentina Adami, Chiara Ambrosini, Francesca Broso, Emanuele Filiberto Rosatti, Sara Longhi, Mariachiara Buccarelli, Quintino G. D’Alessandris, Stefano Giannetti, Simone Pacioni, Lucia Ricci-Vitiani, Joanna Rorbach, Roberto Pallini, Sandrine Roulland, Alexey Amunts, Ines Mancini, Angelika Modelska, Alessandro Quattrone. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00338-7

Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria – Marshall L. Deline, Martin Grashei, Frits H.A. van Heijster, Franz Schilling, Joshua Straub, Tobias Fromme. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000426

Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly – Bennett CF, O’Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P.. https://www.nature.com/articles/s41589-021-00772-z

Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis – Maria E. Solesio, Lihan Xie, Brendan McIntyre, Mathew Ellenberger, Erna Mitaishvili, Siddharth Bhadra-Lobo, Lisa F. Bettcher, Jason N. Bazil, Daniel Raftery, Ursula Jakob, Evgeny V. Pavlov. https://portlandpress.com/biochemj/article-abstract/478/8/1631/228286


Starvation / nutrient sensing


Kog1/Raptor mediates metabolic rewiring during nutrient limitation by controlling SNF1/AMPK activity – Zeenat Rashida , Rajalakshmi Srinivasan, Meghana Cyanam, Sunil Laxman. https://advances.sciencemag.org/content/7/16/eabe5544

THOC4 regulates energy homeostasis by stabilizing TFEB mRNA during prolonged starvation – Toshiharu Fujita, Sayaka Kubo, Tatsuya Shioda, Ayaka Tokumura, SatoshiMinami, Megumi Tsuchiya, Yoshitaka Isaka, Hidesato Ogawa, Maho Hamasaki, Li Yu, Tamotsu Yoshimori and Shuhei Nakamura. http://jcs.biologists.org/content/134/6/jcs248203?etoc

Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation – Sulhee Kim, Ina Yoon, Jonghyeon Son, Junga Park, Kibum Kim, Ji-Ho Lee, Sam-Yong Park, Beom Sik Kang, Jung Min Han, Kwang Yeon Hwang, Sunghoon Kim. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00345-4

Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis – Guang Zhang, Yang Yang, Hao Hu, Kaiyue Liu, Bingyan Li, Yu Zhu, Zhongyu Wang, Qingfa Wu and Yide Mei. https://www.nature.com/articles/s41388-021-01749-x

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy – Chien-Min Hung , Portia S. Lombardo, Nazma Malik, Sonja N. Brun, Kristina Hellberg, Jeanine L. Van Nostrand, Daniel Garcia, Joshua Baumgart, Ken Diffenderfer, John M. Asara, Reuben J. Shaw. https://advances.sciencemag.org/content/7/15/eabg4544


Miscellaneous


The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer – Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern and Pilar Blancafort. https://www.nature.com/articles/s41467-021-22101-7

Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin – David Papadopoli , Oro Uchenunu, Ranveer Palia, Nabila Chekkal, Laura Hulea, Ivan Topisirovic , Michael Pollak, Julie St-Pierre. https://www.sciencedirect.com/science/article/pii/S1476558621000099

Control of endothelial quiescence by FOXO-regulated metabolites – Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza and Michael Potente. https://www.nature.com/articles/s41556-021-00637-6

Metabolic heterogeneity of human hepatocellular carcinoma: implications for personalized pharmacological treatment – Nikolaus Berndt, Johannes Eckstein, Niklas Heucke, Tilo Wuensch, Robert Gajowski, Martin Stockmann, David Meierhofer, Hermann‐Georg Holzhütter. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15587

Proteogenomic and metabolomic characterization of human glioblastoma – Liang-Bo Wang, Alla Karpova, Marina A. Gritsenko et al. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00050-7


Reviews


Metabolic barriers to cancer immunotherapy – Kristin DePeaux and Greg M. Delgoffe. https://www.nature.com/articles/s41577-021-00541-y

Autophagy in tumour immunity and therapy – Houjun Xia, Douglas R. Green and Weiping Zou.  https://www.nature.com/articles/s41568-021-00344-2

Signaling Pathways Involved in Nutrient Sensing Control in Cancer Stem Cells: An Overview – Martha Robles-Flores, Angela P Moreno-Londoño, M Cristina Castañeda-Patlán. https://www.frontiersin.org/articles/10.3389/fendo.2021.627745/full

Linking Serine/Glycine Metabolism to Radiotherapy Resistance – Sánchez-Castillo A, Vooijs M, Kampen KR. https://www.mdpi.com/2072-6694/13/6/1191

Mitochondrial metabolism as a target for acute myeloid leukemia treatment – Svetlana B. Panina, Jingqi Pei and Natalia V. Kirienko. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00253-w

Metabolic implications of non-electrogenic ATP/ADP exchange in cancer cells: A mechanistic basis for the Warburg effect – John J. Lemasters. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000438

Mitochondrial proton leaks and uncoupling proteins – David G. Nicholls. https://www.sciencedirect.com/science/article/pii/S000527282100061X

Glutathione and its precursors in cancer – Gloria Asantewaa, Isaac S Harris. https://www.sciencedirect.com/science/article/abs/pii/S0958166921000458


Comments


Mitochondrial NADPH is a pro at Pro synthesis – Frances F. Diehl and Matthew G. Vander Heiden. https://www.nature.com/articles/s42255-021-00381-z

Fatty acid synthesis enables brain metastasis – Felix C. E. Vogel and Almut Schulze. https://www.nature.com/articles/s43018-021-00202-y

Macropinocytosis: the big drinker behind cancer cell self-consumption – Hua Su, Fei Yang, Beicheng Sun and Michael Karin. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1919969

Glucose makes Treg lose their temper – Matteo Villa, David O’Sullivan, Erika L. Pearce. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00159-8

Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress? – Ralf Baumeister, Coleen T. Murphy and Thomas Heimbucher. https://www.nature.com/articles/s41418-021-00741-y


Conference: SIBBM 2021 “FRONTIERS IN METABOLIC RESEARCH” virtual meeting – June 7th – 10th, 2021

Organized by Graziano Martello, Sirio Dupont, Massimo Santoro. https://sibbm2021.azuleon.org/welcome

One thought on “MetaboList – April 2021

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