MetaboList – June 2021


Glucose metabolism


KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition – Pranavi Koppula, Kellen Olszewski, Yilei Zhang, Lavanya Kondiparthi, Xiaoguang Liu, Guang Lei, Molina Das, Bingliang Fang, Masha V. Poyurovsky, Boyi Gan. https://www.cell.com/iscience/fulltext/S2589-0042(21)00617-9

PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer – Thu H. Truong, Elizabeth A. Benner, Kyla M. Hagen, Nuri A. Temiz, Carlos Perez Kerkvliet, Ying Wang, Emilio Cortes-Sanchez, Chieh-Hsiang Yang, Marygrac e C. Trousdell, Thomas Pengo, Katrin P. Guillen, Bryan E. Welm, Camila O. Dos Santos, Sucheta Telang, Carol A. Lange and Julie H. Ostrander. https://www.nature.com/articles/s41388-021-01871-w

Dual covalent inhibition of PKM and IMPDH targets metabolism in cutaneous metastatic melanoma – Marwa Zerhouni, Anthony R. Martin, Nathan Furstoss, Vincent S. Gutierrez, Emilie Jaune, Nedra Tekaya, Guillaume E. Beranger, Patricia Abbe, Claire Regazzetti, Hella Amdouni, Mohsine Driowya, Patrice Dubreuil, Frédéric Luciano, Arnaud Jacquel, Meri K. Tulic, Thomas Cluzeau, Brendan P. O’Hara, Issam Ben-Sahra, Thierry Passeron, Rachid Benhida, Guillaume Robert, Patrick Auberger and Stéphane Rocchi. https://cancerres.aacrjournals.org/content/early/2021/06/04/0008-5472.CAN-20-2114.long

The role of endoplasmic reticulum in in vivo cancer FDG kinetics – Sara Sommariva, Mara Scussolini, Vanessa Cossu, Cecilia Marini, Gianmario Sambuceti, Giacomo Caviglia, Michele Piana. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252422

Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma – Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara and Florian Muller. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00259-4


Lactate


Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas – Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch’ng, K. Mark Parnell, Nicolás M. Reinoso-Vizcaíno, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, and Micah A. Luftig. https://www.pnas.org/content/118/25/e2022495118.abstract

Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition – Catherine Vander Linden, Cyril Corbet, Estelle Bastien, Ruben Martherus, Céline Guilbaud, Laurenne Petit, Loris Wauthier, Axelle Loriot, Charles De Smet, Olivier Feron. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00551-9

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer – Jiang J, Huang D, Jiang Y, Hou J, Tian M, Li J, Sun L, Zhang Y, Zhang T, Li Z, Li Z, Tong S, Ma Y.. https://www.frontiersin.org/articles/10.3389/fonc.2021.647559/full


Amino acids


Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells – Alice Clare Newman, Mattia Falcone, Alejandro Huerta Uribe, Tong Zhang, Dimitris Athineos, Matthias Pietzke, Alexei Vazquez, Karen Blyth, Oliver David Kenneth Maddocks. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00214-8

SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells – Yingying Tong, Dong Guo, Shu-Hai Lin, Jiazhen Liang, Dianqiang Yang, Chunmin Ma, Fei Shao, Min Li, Qiujing Yu, Yuhui Jiang, Lei Li, Jing Fang, Rilei Yu, Zhimin Lu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00269-0

Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-14 amplification – Thanh H. Nguyen, Prasantha . Vemu, Gregory E. Hoy, Salah Boudjadi, Bishwanath Chatterjee, Jack F. Shern, Javed Khan, Wenyue Sun, and Frederic G. Barr. https://www.jci.org/articles/view/138022


Lipid metabolism


E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment – Francisco González-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O’Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela-Rey, Marta Palomo-Irigoyen, Beatriz Gómez-Santos, Diego Sáenz de Urturi, Maitane Núñez-García, Juan L. García-Rodríguez, Larraitz Fernández-Ares, Xabier Buqué, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C. Delgado, Naroa Goikoetxea-Usandizaga, Richard Lee, Sanjay Bhanot, Igotz Delgado, Maria J. Perugorria, Gaizka Errazti, Lorena Mosteiro, Sonia Gaztambide, Idoia Martinez de la Piscina, Paula Iruzubieta, Javier Crespo, Jesus M. Banales, Maria L. Martínez-Chantar, Luis Castaño, Ana M. Zubiaga and Patricia Aspichueta. https://cancerres.aacrjournals.org/content/81/11/2874

Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma – Daria Capece, Daniel D’Andrea, Federica Begalli, Laura Goracci, Laura Tornatore, James L. Alexander, Alessandra Di Veroli, Shi-Chi Leow, Thamil S. Vaiyapuri, James K. Ellis, Daniela Verzella, Jason Bennett, Luca Savino, Yue Ma, James S. McKenzie, Maria Luisa Doria, Sam E. Mason, Kern Rei Chng, Hector C. Keun, Gary Frost, Vinay Tergaonkar, Katarzyna Broniowska, Walter Stunkel, Zoltan Takats, James M. Kinross, Gabriele Cruciani, and Guido Franzoso. https://www.jci.org/articles/view/137845

Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability – Triana Amen, Daniel Kaganovich. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00596-9

Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development – Hidenori Ito, Ikuko Nakamae, Jun-ya Kato, and Noriko Yoneda-Kato. https://www.jci.org/articles/view/141529

Cancer-associated cells release citrate to support tumour metastatic progression – Konstantin Drexler, Katharina M Schmidt, Katrin Jordan, Marianne Federlin, Vladimir M Milenkovic, Gerhard Liebisch, Anna Artati, Christian Schmidl, Gregor Madej, Janina Tokarz, Alexander Cecil, Wolfgang Jagla, Silke Haerteis, Thiha Aung, Christine Wagner, Maria Kolodziejczyk, Stefanie Heinke, Evan H Stanton, Barbara Schwertner, Dania Riegel, Christian H Wetzel, Wolfgang Buchalla, Martin Proescholdt, Christoph A Klein, Mark Berneburg, Hans J Schlitt, Thomas Brabletz, Christine Ziegler, Eric K Parkinson, Andreas Gaumann, Edward K Geissler, Jerzy Adamski, Sebastian Haferkamp and Maria E Mycielska. https://www.life-science-alliance.org/content/4/6/e202000903.abstract


Nucleotides and NAD


NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma – Tanya Schild, Melanie R. McReynolds, Christie Shea, Vivien Low, Bethany E. Schaffer, John M. Asara, Elena Piskounova, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00597-0

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics – Veerle W. Daniels , Jason J. Zoeller, Nick van Gastel, Kelley E. McQueeney, Salma Parvin, Danielle S. Potter, Geoffrey G. Fell, Vinícius G. Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D. Bhola, Jennifer E. Endress, Isaac S. Harris, Emanuel Carrilho, Kristopher A. Sarosiek, David T. Scadden, Joan S. Brugge, Anthony Letai. https://stke.sciencemag.org/content/14/686/eabc7405

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy – Jian Chen, Risi Na, Chao Xiao, Xiao Wang, Yupeng Wang, Dongwang Yan, Guohe Song, Xueni Liu, Jiayi Chen, Huijun Lu, Chunyan Chen, Huamei Tang, Guohong Zhuang, Guangjian Fan and Zhihai Peng. https://www.nature.com/articles/s41388-021-01815-4

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma – Shunsuke Kunou, Kazuyuki Shimada, Mika Takai, Akihiko Sakamoto, Tomohiro Aoki, Tomoya Hikita, Yusuke Kagaya, Eisuke Iwamoto, Masashi Sanada, Satoko Shimada, Fumihiko Hayakawa, Chitose Oneyama and Hitoshi Kiyoi. https://www.nature.com/articles/s41388-021-01829-y


Mitochondria


ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis – Charles Ricordel, Laura Chaillot, Alice Blondel, Jérôme Archambeau, Florence Jouan, Audrey Mouche, Marie Tiercin, Agnès Burel, Hervé Lena, Benoît Desrues, Thierry Guillaudeux and Rémy Pedeux. https://www.nature.com/articles/s41388-021-01832-3

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex – Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao and Chenji Wang

https://www.nature.com/articles/s41419-021-03908-0


Starvation, nutrient sensing


Sugar phosphate activation of the stress sensor eIF2B – Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong and Carmela Sidrauski. https://www.nature.com/articles/s41467-021-23836-z

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase – Simon Klaessens, Vincent Stroobant, Delia Hoffmann, Mads Gyrd-Hansen, Luc Pilotte, Nathalie Vigneron, Etienne De Plaen, and Benoit J. Van den Eynde. https://www.pnas.org/content/118/23/e2022447118.abstract?etoc

TOR and MAP kinase pathways synergistically regulate autophagy in response to nutrient depletion in fission yeast – Cristina Corral-Ramos, Rubén Barrios, José Ayté and Elena Hidalgo. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1935522

Pharmacological preconditioning protects from ischemia/reperfusion‐induced apoptosis by modulating Bcl‐xL expression through a ROS‐dependent mechanism – Romain Rozier, Rachel Paul, Blandine Madji Hounoum, Elodie Villa, Rana Mhaidly, Johanna Chiche, Els Verhoeyen, Sandrine Marchetti, Ashaina Vandenberghe, Marc Raucoules, Michel Carles, Jean-Ehrland Ricci. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15675

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1 – Mengqi Li, Chen-Song Zhang, Jin-Wei Feng, Xiaoyan Wei, Cixiong Zhang, Changchuan Xie, Yaying Wu, Simon A. Hawley, Abdelmadjid Atrih, Douglas J. Lamont, Zhichao Wang, Hai-Long Piao, D. Grahame Hardie and Sheng-Cai Lin. https://www.nature.com/articles/s41422-020-00456-8


mTOR


Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling – Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini and Alejo Efeyan. https://www.nature.com/articles/s41467-021-23857-8

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals – Jun Jin , Chulwoo Kim, Qiong Xia, Timothy M. Gould, Wenqiang Cao, Huimin Zhang, Xuanying Li, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Cornelia M. Weyand, Jorg J. Goronzy. https://immunology.sciencemag.org/content/6/60/eabg0791

ArfGAP1 inhibits mTORC1 lysosomal localization and activation – Delong Meng, Qianmei Yang, Chase H Melick, Brenden C Park, Ting-Sung Hsieh, Adna Curukovic, Mi-Hyeon Jeong, Junmei Zhang, Nicholas G James, Jenna L Jewell. https://www.embopress.org/doi/full/10.15252/embj.2020106412

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia – Zengzhang Zheng, Wanyan Deng, Yang Bai, Rui Miao, Shenglin Mei, Zhibin Zhang, Youdong Pan, Yi Wang, Rui Min, Fan Deng, Zeyu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, Judy Lieberman, Xing Liu. https://science.sciencemag.org/content/372/6549/eabg0269

Vps34 and TOR Kinases Coordinate HAC1 mRNA Translation in the Presence or Absence of Ire1-Dependent Splicing – Jagadeesh Kumar Uppala, Sankhajit Bhattacharjee, and Madhusudan Dey. https://doi.org/10.1128/MCB.00662-20

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1 – Raphael Böhm, Stefan Imseng, Roman P. Jakob, Michael N. Hall, Timm Maier, Sebastian Hiller. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00226-4

TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose – Yusuke Toyoda ; Saeko Soejima; Fumie Masuda; Shigeaki Saitoh. https://journals.biologists.com/jcs/article-abstract/134/10/jcs257485/268339


Hypoxia and HIFs


Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination–deficient cancer models – Manal Mehibel, Yu Xu, Caiyun G. Li, Eui Jung Moon, Kaushik N. Thakkar, Anh N. Diep, Ryan K. Kim, Joshua D. Bloomstein, Yiren Xiao, Julien Bacal, Joshua C. Saldivar, Quynh-Thu Le, Karlene A. Cimprich, Erinn B. Rankin, and Amato J. Giaccia. https://www.jci.org/articles/view/146256

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron – Rashi Singhal, Sreedhar R. Mitta, Nupur K. Das, Samuel A. Kerk, Peter Sajjakulnukit, Sumeet Solanki, Anthony Andren, Roshan Kumar, Kenneth P. Olive, Ruma Banerjee, Costas A. Lyssiotis, and Yatrik M. Shah. https://www.jci.org/articles/view/143691

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes – Travis Peng, Shin-Yi Du, Myoungsun Son, and Betty Diamond. https://www.pnas.org/content/118/26/e2106017118.abstract?etoc


Cancer Immunometabolism


Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD – Hsin-Fang Tu, Chun-Jung Ko, Ching-Tai Lee, Cheng-Fan Lee, Shao-Wei Lan, Hsin-Hsien Lin, Hsin-Ying Lin, Chia-Chi Ku, Der-Yen Lee, I-Chun Chen, Ya-Hui Chuang, Francisco Del Caño-Ochoa, Santiago Ramón-Maiques, Chao-Chi Ho, Ming-Shyue Lee and Geen-Dong Chang. https://cancerres.aacrjournals.org/content/81/12/3270

Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors – Lin Wang, Luz M. Londono, Jessica Cowell, Ozge Saatci, Mertkaya Aras, Pelin G. Ersan, Sara Serra, Hong Pei, Renee Clift, Qiping Zhao, Kim B. Phan, Lei Huang, Michael J. LaBarre, Xiaoming Li, H. Michael Shepard, Silvia Deaglio, Joel Linden, Christopher D. Thanos, Ozgur Sahin and Caglar Cekic. https://cancerres.aacrjournals.org/content/81/12/3319

Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function – Sam Sheppard, Endi K. Santosa, Colleen M. Lau, Sara Violante, Paolo Giovanelli, Hyunu Kim, Justin R. Cross, Ming O. Li, Joseph C. Sun. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00559-3

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment – Sophie M. Poznanski, Kanwaldeep Singh, Tyrah M. Ritchie, Jennifer A. Aguiar, Isabella Y. Fan, Ana L. Portillo, Eduardo A. Rojas, Fatemeh Vahedi, Abdullah El-Sayes, Sansi Xing, Martin Butcher, Yu Lu, Andrew C. Doxey, Jonathan D. Schertzer, Hal W. Hirte, Ali A. Ashkar. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00130-3

Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade – Xiaoming Dai, Xia Bu, Yang Gao, Jianping Guo, Jia Hu, Cong Jiang, Zhao Zhang, Kexin Xu, Jinzhi Duan, Shaohui He, Jinfang Zhang, Lixin Wan, Tianjie Liu, Xiaobo Zhou, Mien-Chie Hung, Gordon J. Freeman, Wenyi Wei. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00232-X


Cachexia


Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia – Joseph E. Rupert; Ashok Narasimhan ; Daenique H.A. Jengelley; Yanlin Jiang; Jianguo Liu; Ernie Au; Libbie M. Silverman ; George Sandusky; Andrea Bonetto; Sha Cao; Xiaoyu Lu; Thomas M. O’Connell ; Yunlong Liu; Leonidas G. Koniaris; Teresa A. Zimmers. https://rupress.org/jem/article/218/6/e20190450/211985

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models – Mengyuan Niu, Li Li, Zhonglan Su, Lulu Wei, Wenyuan Pu, Chen Zhao, Yibing Ding, Junaid Wazir, Wangsen Cao, Shiyu Song, Qian Gao and Hongwei Wang. https://www.nature.com/articles/s41419-021-03932-0


Miscellaneous


In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor – Jacob P. Keller, Jonathan S. Marvin, Haluk Lacin, William C. Lemon, Jamien Shea, Soomin Kim, Richard T. Lee, Minoru Koyama, Philipp J. Keller, Loren L. Looger. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00656-2

Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma – Jianhua Cao, Benjamin Balluff, Martijn Arts, Ludwig J. Dubois, Luc J. C. van Loon, Tilman M. Hackeng, Hans M. H. van Eijk, Gert Eijkel, Lara R. Heij, Zita Soons, Steven W. M. Olde Damink and Ron M. A. Heeren. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00262-9

Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation – Jiao-Jiao Zhang, Ting-Ting Fan, Yun-Zi Mao, Jun-Li Hou, Meng Wang, Min Zhang, Yan Lin, Lei Zhang, Guo-Quan Yan, Yan-Peng An, Jun Yao, Cheng Zhang, Peng-Cheng Lin, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu and Shi-Min Zhao. https://www.nature.com/articles/s42255-021-00405-8

The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study – Huaili Jiang, Lei Zhou, Qiangsheng He, Kanglun Jiang, Jinqiu Yuan and Xinsheng Huang. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00261-w


Reviews


Targeting the Metabolic Adaptation of Metastatic Cancer – Josep Tarragó-Celada and Marta Cascante. https://www.mdpi.com/2072-6694/13/7/1641

Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure – Kosaku Uyeda. https://www.annualreviews.org/doi/10.1146/annurev-biochem-070820-125228

Assays for Determination of Cellular and Mitochondrial NAD+ and NADH Content – Yue Yang, Anthony A. Sauve. https://link.springer.com/protocol/10.1007%2F978-1-0716-1433-4_15

Mitochondrial DNA variation and cancer – Piotr K. Kopinski, Larry N. Singh, Shiping Zhang, Marie T. Lott and Douglas C. Wallace. https://www.nature.com/articles/s41568-021-00358-w

Role of NAD+ in regulating cellular and metabolic signaling pathways – Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris, Ravinder Reddy, Zoltan Patay, Joseph Baur, Puneet Bagga. https://www.sciencedirect.com/science/article/pii/S2212877821000351

Lipid droplets and the host–pathogen dynamic: FATal attraction? – Marta Bosch, Matthew J. Sweet, Robert G. Parton, Albert Pol. https://rupress.org/jcb/article-abstract/220/8/e202104005/212436

The role of polyamines in gastric cancer – Kara M. McNamara, Alain P. Gobert and Keith T. Wilson. https://www.nature.com/articles/s41388-021-01862-x


Comments


Can tumor cells take it all away? – Anna Kohl, Kung-Chi Kao, Ping-Chih Ho. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00227-8

Creatine promotes metastatic dissemination – Damien Lagarde, Lawrence Kazak. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00229-1

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