MetaboList – July 2021

 

Join us for an EMBO workshop on Cancer Immunometabolism near Barcelona! 

Early bird registration deadline August 15th.  See more details below.

 


Starvation / nutrient sensing


SAR1B senses leucine levels to regulate mTORC1 signalling – Jie Chen, Yuhui Ou, Rong Luo, Jie Wang, Dong Wang, Jialiang Guan, Yi Li, Peixue Xia, Peng R. Chen and Ying Liu. https://www.nature.com/articles/s41586-021-03768-w

RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal – Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00868-8

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner – Cansu Karabiyik, Mariella Vicinanza, Sung Min Son, David C. Rubinsztein. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00439-1

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness – Yijuan Zhang, M. Victoria Recouvreux, Michael Jung, Koen M.O. Galenkamp, Yunbo Li, Olga Zagnitko, David A. Scott, Andrew M. Lowy and Cosimo Commisso. https://cancerdiscovery.aacrjournals.org/content/11/7/1808


mTOR / AMPK


Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin – Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD.. https://www.sciencedirect.com/science/article/pii/S2212877821001563

Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs – Ana Ortega-Molina, Cristina Lebrero-Fernández, Alba Sanz, Nerea Deleyto-Seldas, Ana Belén Plata-Gómez, Camino Menéndez, Osvaldo Graña-Castro, Eduardo Caleiras, Alejo Efeyan. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00770-1

Gαq activation modulates autophagy by promoting mTORC1 signaling – Sofía Cabezudo, Maria Sanz-Flores, Alvaro Caballero, Inmaculada Tasset, Elena Rebollo, Antonio Diaz, Anna M. Aragay, Ana María Cuervo, Federico Mayor Jr and Catalina Ribas. https://www.nature.com/articles/s41467-021-24811-4

Structure of an AMPK complex in an inactive, ATP-bound state – Yan Yan, Somnath Mukherjee, Kaleeckal G. Harikumar, Timothy S. Strutzenberg, X. Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D. Sheldon, Jared Lamp, Joseph S. Brunzelle, Katarzyna Radziwon, Abigail Ellis, Scott J. Novick, Irving E. Vega, Russell G. Jones, Laurence J. Miller, H. Eric Xu, Patrick R. Griffin, Anthony A. Kossiakoff, Karsten Melcher. https://science.sciencemag.org/content/373/6553/413

Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2 – Christelle Harly , Stephen Paul Joyce, Charlotte Domblides, Thomas Bachelet, Vincent Pitard, Charlotte Mannat, Angela Pappalardo, Lionel Couzi, Sonia Netzer, Layal Massara, Emilie Obre, Omar Hawchar, Lydia Lartigue, Stéphane Claverol, Carla Cano, Jean-François Moreau, Isabelle Mahouche, Isabelle Soubeyran, Rodrigue Rossignol, Benoit Viollet, Carrie R. Willcox, Fiyaz Mohammed, Benjamin E. Willcox, Benjamin Faustin, Julie Déchanet-Merville.https://immunology.sciencemag.org/content/6/61/eaba9010


Hypoxia


Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy – Audrey Lequeux, Muhammad Zaeem Noman, Malina Xiao, Kris Van Moer, Meriem Hasmim, Alice Benoit, Manon Bosseler, Elodie Viry, Tsolere Arakelian, Guy Berchem, Salem Chouaib and Bassam Janji. https://www.nature.com/articles/s41388-021-01846-x

Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α – Leonard A. Daly , Philip J. Brownridge, Michael Batie, Sonia Rocha, Violaine Sée, Claire E. Eyers. https://stke.sciencemag.org/content/14/692/eabf6685


Glucose metabolism


Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect – Elizabeth K. Wiese, Sadae Hitosugi, Sharon T. Loa, Annapoorna Sreedhar, Lindsey G. Andres-Beck, Kiran Kurmi, Yuan-Ping Pang, Larry M. Karnitz, Wilson I. Gonsalves and Taro Hitosugi. https://www.nature.com/articles/s42255-021-00424-5

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs – Chia-Hung Chen, Bo-Wei Wang, Yu-Chun Hsiao, Chun-Yi Wu, Fang-Ju Cheng, Te-Chun Hsia, Chih-Yi Chen, Yihua Wang, Zhang Weihua, Ruey-Hwang Chou, Chih-Hsin Tang, Yun-Ju Chen, Ya-Ling Wei, Jennifer L. Hsu, Chih-Yen Tu, Mien-Chie Hung and Wei-Chien Huang. https://www.nature.com/articles/s41388-021-01889-0


Amino acid metabolism


Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition – George Sharbeen, Joshua A. McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R. Cox, Brooke A. Pereira, Jessica L. Chitty, Sigrid K. Fey, Arafath K. Najumudeen, Andrew D. Campbell, Owen J. Sansom, Rosa Mistica C. Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J. Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti V. Apte, Thomas P. Davis, Jennifer P. Morton, Koroush S. Haghighi, Jorjina Kasparian, Benjamin J. McLean, Yordanos F. Setargew; Australian Pancreatic Cancer Genome Initiative and Phoebe A. Phillips. https://cancerres.aacrjournals.org/content/81/13/3461

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis – Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu and Shu Li. https://www.nature.com/articles/s41467-021-24321-3

Structural and biochemical properties of L‐asparaginase – Jacek Lubkowski, Alexander Wlodawer. https://stm.sciencemag.org/content/13/604/eabb1069

Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway – Bingbing Dai, Jithesh J. Augustine, Ya’an Kang, David Roife, Xinqun Li, Jenying Deng, Lin Tan, Leona A. Rusling, John N. Weinstein, Philip L. Lorenzi, Michael P. Kim and Jason B. Fleming. https://www.nature.com/articles/s41419-021-03970-8


Lipid metabolism


SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis – Elma Zaganjor, Haejin Yoon, Jessica B. Spinelli, Elizabeth R. Nunn, Gaëlle Laurent, Paulina Keskinidis, Suganja Sivaloganathan, Shakchhi Joshi, Giulia Notarangelo, Stacy Mulei, Mathew T. Chvasta, Sarah A. Tucker, Krystle Kalafut, Robert A.H. van de Ven, Clary B. Clish, Marcia C. Haigis. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00721-X

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer – Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler and De-Chen Lin. https://www.nature.com/articles/s41467-021-24656-x


Nucleotides


p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage – Gen Li, Jun Wu, Le Li, and Peng Jiang. https://www.pnas.org/content/118/28/e2019822118.abstract?etoc

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia – Daniela Di Marcantonio, Esteban Martinez, Joice S. Kanefsky, Jacklyn M. Huhn, Rashid Gabbasov, Anushk Gupta, John J. Krais, Suraj Peri, YinFei Tan, Tomasz Skorski, Adrienne Dorrance, Ramiro Garzon, Aaron R. Goldman, Hsin-Yao Tang, Neil Johnson, Stephen M. Sykes. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00365-8

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells – Andrew J. Schwartz, Joshua W. Goyert, Sumeet Solanki, Samuel A. Kerk, Brandon Chen, Cristina Castillo, Peggy P. Hsu, Brian T. Do, Rashi Singhal, Michael K. Dame, Ho-Joon Lee, Jason R. Spence, Samira Lakhal-Littleton, Matthew G. Vander Heiden, Costas A. Lyssiotis, Xiang Xue and Yatrik M. Shah. https://www.nature.com/articles/s42255-021-00424-5

Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells – Xiangguo Shi , Yajian Jiang, Ayumi Kitano, Tianyuan Hu, Rebecca L. Murdaugh, Yuan Li, Kevin A. Hoegenauer, Rui Chen, Koichi Takahashi, Daisuke Nakada. https://advances.sciencemag.org/content/7/30/eabf3895


Mitochondria


Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate – Judith Goncalves, Sophie Moog, Aurélie Morin, Géraldine Gentric, Sebastian Müller, Alexander P. Morrell, Katarina Kluckova, Theodora J. Stewart, Cynthia L. Andoniadou, Charlotte Lussey-Lepoutre, Paule Bénit, Alpesh Thakker, Lisa Vettore, Jennie Roberts, Raphaël Rodriguez, Fatima Mechta-Grigoriou, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Daniel A. Tennant and Judith Favier. https://cancerres.aacrjournals.org/content/81/13/3480

BCL(X)L and BCL2 increase mitochondrial dynamics in breast cancer cell: Evidence from functional and genetic studies – Federico Lucantoni, Manuela Salvucci, Heiko Dussmann, Jochen H.M.Prehn. https://www.sciencedirect.com/science/article/abs/pii/S016748892100149X


Cancer Immunometabolism


Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors – Shihao Xu, Omkar Chaudhary, Patricia Rodríguez-Morales, Xiaoli Sun, Dan Chen, Roberta Zappasodi, Ziyan Xu, Antonio F.M. Pinto, April Williams, Isabell Schulze, Yagmur Farsakoglu, Siva Karthik Varanasi, Jun Siong Low, Wenxi Tang, Haiping Wang, Bryan McDonald, Victoria Tripple, Michael Downes, Ronald M. Evans, Nada A. Abumrad, Taha Merghoub, Jedd D. Wolchok, Maxim N. Shokhirev, Ping-Chih Ho, Joseph L. Witztum, Brinda Emu, Guoliang Cui, Susan M. Kaech. https://www.cell.com/immunity/fulltext/S1074-7613(21)00209-0

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation – Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, German R. Aleman-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sanchez-Lopez. https://www.cell.com/immunity/fulltext/S1074-7613(21)00210-7

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas – Mirco Friedrich, Roman Sankowski, Lukas Bunse, Michael Kilian, Edward Green, Carina Ramallo Guevara, Stefan Pusch, Gernot Poschet, Khwab Sanghvi, Markus Hahn, Theresa Bunse, Philipp Münch, Hagen M. Gegner, Jana K. Sonner, Anna von Landenberg, Frederik Cichon, Katrin Aslan, Tim Trobisch, Lucas Schirmer, Denis Abu-Sammour, Tobias Kessler, Miriam Ratliff, Daniel Schrimpf, Felix Sahm, Carsten Hopf, Dieter H. Heiland, Oliver Schnell, Jürgen Beck, Chotima Böttcher, Camila Fernandez-Zapata, Josef Priller, Sabine Heiland, Ilona Gutcher, Francisco J. Quintana, Andreas von Deimling, Wolfgang Wick, Marco Prinz and Michael Platten. https://www.nature.com/articles/s43018-021-00201-z


Miscellaneous


Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells – Kouichi Yanagi, Toru Komatsu, Shusuke Ogihara, Takayoshi Okabe, Hirotatsu Kojima, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00687-2

SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides – Yoshiki Ikeda, Akiyoshi Hirayama, Satoshi Kofuji, Yoshihisa Hirota, Ryo Kamata, Natsuki Osaka, Yuki Fujii, Mika Sasaki, Satsuki Ikeda, Eric P Smith, Robert Bachoo, Tomoyoshi Soga, Atsuo T Sasaki. https://academic.oup.com/jb/advance-article-abstract/doi/10.1093/jb/mvab077/6318401

Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma – Daniel J. Silver, Gustavo A. Roversi, Nazmin Bithi, Sabrina Z. Wang, Katie M. Troike, Chase K.A. Neumann, Grace K. Ahuja, Ofer Reizes, J. Mark Brown, Christopher Hine, Justin D. Lathia. https://www.jci.org/articles/view/138276

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine – Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri and Florian L. Muller. https://www.nature.com/articles/s41467-021-24240-3


Reviews


Cancer metabolism: looking forward – Inmaculada Martínez-Reyes and Navdeep S. Chandel. https://www.nature.com/articles/s41568-021-00378-6

The Complex Integration of T-cell Metabolism and Immunotherapy – Matthew Z. Madden, and Jeffrey C. Rathmell. https://cancerdiscovery.aacrjournals.org/content/11/7/1636

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment – Samuel A. Kerk, Thales Papagiannakopoulos, Yatrik M. Shah and Costas A. Lyssiotis. https://www.nature.com/articles/s41568-021-00375-9

Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer – Violet Y. Tu, Asma Ayari and Roddy S. O’Connor. https://www.mdpi.com/2073-4468/10/3/25/htm

The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species – Brandán Pedre, Uladzimir Barayeu, Daria Ezeriņa, Tobias P. Dick. https://www.sciencedirect.com/science/article/pii/S0163725821001182

Quantitative flux analysis in mammals – Caroline R Bartman, Tara TeSlaa, Joshua D Rabinowitz.. https://www.nature.com/articles/s42255-021-00419-2

Peroxisomes as cellular adaptors to metabolic and environmental stress – Anyuan He, John M. Dean, Irfan J. Lodhi. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00030-1

ATP and cancer immunosurveillance – Oliver Kepp, Lucillia Bezu, Takahiro Yamazaki, Francesco Di Virgilio, Mark J Smyth, Guido Kroemer, Lorenzo Galluzzi. https://www.embopress.org/doi/abs/10.15252/embj.2021108130

Regulation of Autophagy Enzymes by Nutrient Signaling – Karyn E. King, Truc T. Losier, Ryan C. Russell. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00020-7

The mTOR–Autophagy Axis and the Control of Metabolism – Nerea Deleyto-Seldas and Alejo Efeyan. https://www.frontiersin.org/articles/10.3389/fcell.2021.655731/full

Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer – Macus Hao-Ran Bao and Carmen Chak-Lui Wong. https://www.mdpi.com/2073-4409/10/7/1715

Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers – Juan C García-Cañaveras 1, Agustín Lahoz. https://www.mdpi.com/2072-6694/13/13/3230

Targeting Serine in Cancer: Is Two Better Than One? – Aitziber Buqué, Lorenzo Galluzzi, David C. Montrose. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00134-5

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma – Anna Han, Zachary T. Schug, Andrew E. Aplin. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00106-0

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids – Erica Pranzini, Elisa Pardella, Paolo Paoli, Sarah-Maria Fendt, Maria Letizia Taddei. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00046-7

Metabolic Plasticity of Neutrophils: Relevance to Pathogen Responses and Cancer – Thomas Rogers, Ralph J. DeBerardinis. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00099-6

Therapeutic Repurposing of Biguanides in Cancer – Hongyun Zhao, Kenneth D. Swanson, Bin Zheng. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00064-9

Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment – Anna M. Chiarella, Yun K. Ryu, Gulam A. Manji, Anil K. Rustgi. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00100-X

Immunometabolism: A ‘Hot’ Switch for ‘Cold’ Pediatric Solid Tumors – Lin Xiao, Harrison Yeung, Michelle Haber, Murray D. Norris, Klaartje Somers. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00103-5

Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity – Eileen White, Edmund C. Lattime, Jessie Yanxiang Guo. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00104-7

Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy – Wen-Hsuan Yang, Yijian Qiu, Olivia Stamatatos, Tobias Janowitz, Michael J. Lukey. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00083-2


Comments


How the amino acid leucine activates the key cell-growth regulator mTOR – Tibor Vellai. https://www.nature.com/articles/d41586-021-01943-7

Is glucose the scapegoat for tumor evasion? – Lydia N. Raines, Stanley Ching-Cheng Huang. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00327-5

Hunger brings down the tumor fort – Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00097-0

Oxidative phosphorylation system and cell culture media – Pilar Bayona-Bafaluy, Julio Montoya, Eduardo Ruiz-Pesini. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00095-7

2-HG modulates glioma macrophages via Trp metabolism – Marie Jo Halaby and Tracy L. McGaha. https://www.nature.com/articles/s43018-021-00231-7

Zebrafish as a New Model to Study the Crosstalk between Tumor and Host Metabolism – Emily Montal, Richard M. White. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00138-2

IDH-Mutant Brain Tumors Hit the Achilles’ Heel of Macrophages with R-2-Hydroxyglutarate – Xanthe A.M.H. van Dierendonck, Kyra E. de Goede, Jan Van den Bossche. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00133-3

 

 

Cancer immunometabolism – EMBO Workshop

29 November – 01 December 2021 | Sitges, Barcelona, Spain – Hybrid conference

We will issue full refunds in case of COVID-related travel restrictions, and you can also join us online.

Organized by Cristina Muñoz Pinedo, Jean-Ehrland Ricci and Eric Eldering

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https://meetings.embo.org/event/21-cancer

 

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