MetaboList – August 2021

Dear all,

registrations and abstract submission are still open for two meetings in autumn in the Barcelona area:

EMBO Cancer Immunometabolism

https://meetings.embo.org/event/21-cancer – fellowships available

7th MetNet International annual meeting

https://scb.iec.cat/7th-metnet-international-annual-meeting-2021/

Both can be attended remotely online.

Best,

Cristina


Glucose metabolism


UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth – Andrew L. Wolfe, Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A. Ku, Richard P. Koche, Sourav Bandyopadhyay, Maurizio Scaltriti, Carlito B. Lebrilla, Frank McCormick, and Sung Eun Kim. https://www.pnas.org/content/118/31/e2103592118.abstract?etoc

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition – Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya’an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao and Haoqiang Ying. https://cancerres.aacrjournals.org/content/81/15/4054

The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer – Pei Yu, Xiong Zhu, Jia-Le Zhu, Yu-Bao Han, Hao Zhang, Xiang Zhou, Lei Yang, Yuan-Zheng Xia, Chao Zhang and Ling-Yi Kong. https://www.nature.com/articles/s41388-021-01933-z

Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes – Maria Apostolidi, Ioannis A. Vathiotis, Viswanathan Muthusamy, Patricia Gaule, Brandon M. Gassaway, David L. Rimm and Jesse Rinehart. https://cancerres.aacrjournals.org/content/81/16/4346

Thioredoxin reductase is a major regulator of metabolism in leukemia cells – Sheelarani Karunanithi, Ruifu Liu, Yongchun Hou, Giancarlo Gonzalez, Natasha Oldford, Anne Jessica Roe, Nethrie Idipilly, Kalpana Gupta, Chandra Sekhar Amara, Satwikreddy Putluri, Grace Kyueun Lee, Juan Valentin-Goyco, Lindsay Stetson, Stephen A. Moreton, Vasanta Putluri, Shyam M. Kavuri, Yogen Saunthararajah, Marcos de Lima, Gregory P. Tochtrop, Nagireddy Putluri and David N. Wald. https://www.nature.com/articles/s41388-021-01924-0

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria – Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M. Zerbes, Katelyn O’Neill, Martin van der Laan, Xu Luo, and Frank Edlich. https://www.pnas.org/content/118/33/e2021175118.abstract


Amino acid metabolism


GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis – Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive and Costas A. Lyssiotis. https://www.nature.com/articles/s41467-021-24859-2

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis – Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad del Socorro Murdoch, Victor H. Villar and Raúl V. Durán. https://www.nature.com/articles/s41467-021-25079-4

The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer – Alexandra Giatromanolaki, Adrian L. Harris and Michael I. Koukourakis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00264-7

Snail enhances arginine synthesis by inhibiting ubiquitination‐mediated degradation of ASS1 – Hao Jia, Yuquan Yang, Mengying Li, Yimin Chu, Huan Song, Jie Zhang, Dan Zhang, Qun Zhang, Ying Xu, Jiamin Wang, Hong Xu, Xiuqun Zou, Haixia Peng, Zhaoyuan Hou. https://www.embopress.org/doi/abs/10.15252/embr.202051780

Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase – Ronghui Yang, Zihao Guo, Yiliang Zhao, Lingdi Ma, Binghui Li and Chuanzhen Yang. https://www.nature.com/articles/s41420-021-00590-1


Lipid metabolism


Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance – Sze Kiat Tan, Iqbal Mahmud, Flavia Fontanesi, Michelle Puchowicz, Chase K.A. Neumann, Anthony J. Griswold, Rutulkumar Patel, Marco Dispagna, Hamzah H. Ahmed, Mark L. Gonzalgo, J. Mark Brown, Timothy J. Garrett and Scott M. Welford. https://cancerdiscovery.aacrjournals.org/content/11/8/2072

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy – Magali Humbert, Kristina Seiler, Severin Mosimann, Vreni Rentsch, Katyayani Sharma, Amit V. Pandey, Sharon L. McKenna and Mario P. Tschan. https://www.nature.com/articles/s41418-021-00768-1

Gut Microbiota–Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling – Makoto Matsushita, Kazutoshi Fujita, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Kentaro Jingushi, Gaku Yamamichi, Satoru Yumiba, Eisuke Tomiyama, Yoko Koh, Yujiro Hayashi, Kosuke Nakano, Cong Wang, Yu Ishizuya, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Maria D.C. Rodriguez Pena, Jennifer B. Gordetsky, George J. Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda and Norio Nonomura. https://cancerres.aacrjournals.org/content/81/15/4014

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies – Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan and Rosalie C. Sears. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00263-8

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects – Emeline Dierge, Elena Debock, Céline Guilbaud, Cyril Corbet, Eric Mignolet, Louise Mignard, Estelle Bastien, Chantal Dessy, Yvan Larondelle, Olivier Feron. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00233-3

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer – Wen Liu, Binita Chakraborty, Rachid Safi, Dmitri Kazmin, Ching-yi Chang and Donald P. McDonnell. https://www.nature.com/articles/s41467-021-25354-4


Nucleotides and one carbon


Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification – Thanh H. Nguyen, Prasantha L. Vemu, Gregory E. Hoy, Salah Boudjadi, Bishwanath Chatterjee, Jack F. Shern, Javed Khan, Wenyue Sun, and Frederic G. Barr. https://www.jci.org/articles/view/138022

Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression – Nora Pällmann, Ke Deng, Marte Livgård, Martina Tesikova, Yixin Jin, Nicolai Sebastian Frengen, Nermin Kahraman, Hamada M. Mokhlis, Bulent Ozpolat, Wanja Kildal, Havard Emil Danielsen, Ladan Fazli, Paul S. Rennie, Partha P. Banerjee, Aykut Üren, Yang Jin, Omer F. Kuzu and Fahri Saatcioglu. https://cancerres.aacrjournals.org/content/81/15/4066

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma – Yajie Yu, Jane Ding, Shunqin Zhu, Ahmet Alptekin, Zheng Dong, Chunhong Yan, Yunhong Zha and Han-Fei Ding. https://www.nature.com/articles/s41419-021-04120-w


Mitochondria


Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia – Junyan Lu, Ester Cannizzaro, Fabienne Meier-Abt, Sebastian Scheinost, Peter-Martin Bruch, Holly A. R. Giles, Almut Lütge, Jennifer Hüllein, Lena Wagner, Brian Giacopelli, Ferran Nadeu, Julio Delgado, Elías Campo, Maurizio Mangolini, Ingo Ringshausen, Martin Böttcher, Dimitrios Mougiakakos, Andrea Jacobs, Bernd Bodenmiller, Sascha Dietrich, Christopher C. Oakes, Thorsten Zenz and Wolfgang Huber. https://www.nature.com/articles/s43018-021-00216-6

International initiative for a curated SDHB variant database improving the diagnosis of hereditary paraganglioma and pheochromocytoma – Laurene Ben Aim, Eamonn R Maher, Alberto Cascon, Anne Barlier, Sophie Giraud, Tonino Ercolino6, Pascal Pigny, Roderick J Clifton-Bligh8, Delphine Mirebeau-Prunier, Amira Mohamed, Judith Favier, Anne-Paule Gimenez-Roqueplo, Francesca Schiavi1, Rodrigo A Toledo, Patricia L Dahia, Mercedes Robledo, Jean Pierre Bayley, Nelly Burnichon. https://jmg.bmj.com/content/early/2021/08/26/jmedgenet-2020-107652


mTOR / AMPK


The TOR‐dependent phosphoproteome and regulation of cellular protein synthesis – Tiffany Mak, Andrew W Jones, Paul Nurse. https://www.embopress.org/doi/full/10.15252/embj.2021107911

AMPKα loss promotes KRAS-mediated lung tumorigenesis – Manuela La Montagna, Lei Shi, Peter Magee, Sudhakar Sahoo, Matteo Fassan and Michela Garofalo. https://www.nature.com/articles/s41418-021-00777-0

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965 – Danial Ahwazi; Katyayanee Neopane; Greg R. Markby; Franziska Kopietz; Ashley J. Ovens ; Morten Dall; Anna S. Hassing; Pamina Gräsle; Yazeed Alshuweishi; Jonas T. Treebak ; Ian P. Salt; Olga Göransson; Elton Zeqiraj; John W. Scott; Kei Sakamoto. https://portlandpress.com/biochemj/article/478/15/2977/229245/Investigation-of-the-specificity-and-mechanism-of


Hypoxia


Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization – Yufeng Wang , Yajing Lyu, Kangsheng Tu, Qiuran Xu, Yongkang Yang, Shaima Salman, Nguyet Le, Haiquan Lu, Chelsey Chen, Yayun Zhu, Ru Wang, Qingguang Liu, Gregg L. Semenza. https://advances.sciencemag.org/content/7/35/eabe3771

Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer – Vineet K. Gupta, Nikita S. Sharma, Brittany Durden, Vanessa T. Garrido, Kousik Kesh, Dujon Edwards, Dezhen Wang, Ciara Myer, Beatriz Mateo-Victoriano, Sai Sundeep Kollala, Yuguang Ban, Zhen Gao, Sanjoy K. Bhattacharya, Ashok Saluja, Pankaj K. Singh and Sulagna Banerjee. https://cancerres.aacrjournals.org/content/81/15/4001


Cancer Immunometabolism


Standardized Uptake Value for 18F-Fluorodeoxyglucose Is a Marker of Inflammatory State and Immune Infiltrate in Cervical Cancer – John M. Floberg, Jin Zhang, Naoshad Muhammad, Todd A. DeWees, Matthew Inkman, Kevin Chen, Alexander J. Lin, Ramachandran Rashmi, Kay Jayachandran, Brian T. Edelson, Barry A. Siegel, Farrokh Dehdashti, Perry W. Grigsby, Stephanie Markovina and Julie K. Schwarz. https://clincancerres.aacrjournals.org/content/27/15/4245


Miscellaneous


O-GlcNAcylated p53 in the liver modulates hepatic glucose production – Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D. Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M. Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck and Ruben Nogueiras. https://www.nature.com/articles/s41467-021-25390-0

Diabetes Risk Reduction Diet and Survival after Breast Cancer Diagnosis – Tengteng Wang, Maryam S. Farvid, Jae H. Kang, Michelle D. Holmes, Bernard A. Rosner, Rulla M. Tamimi, Walter C. Willett and A. Heather Eliassen. https://cancerres.aacrjournals.org/content/81/15/4155

Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma – Sureerat Padthaisong, Jutarop Phetcharaburanin, Poramate Klanrit, Jia V. Li, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Arporn Wangwiwatsin, Panupong Mahalapbutr and Watcharin Loilome. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00266-5

Inflammatory metabolic profile of South African patients with prostate cancer – Stefano Cacciatore, Martha Wium, Cristina Licari, Aderonke Ajayi-Smith, Lorenzo Masieri, Chanelle Anderson, Azola Samkele Salukazana, Lisa Kaestner, Marco Carini, Giuseppina M. Carbone, Carlo V. Catapano, Massimo Loda, Towia A. Libermann and Luiz F. Zerbini. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00265-6

Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration – Le Qi, Misty S. Martin-Sandoval, Salma Merchant, Wen Gu, Matthias Eckhardt, Thomas P. Mathews, Zhiyu Zhao, Michalis Agathocleous, Sean J. Morrison. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00296-4


Reviews


The context-specific roles of urea cycle enzymes in tumorigenesis – Emma Haja,, Marco Sciacovelli, Christian Frezza, Ayelet Erez. https://www.sciencedirect.com/science/article/abs/pii/S1097276521006456

Autophagy is a major metabolic regulator involved in cancer therapy resistance – Laura Poillet-Perez, Jean-Emmanuel Sarry, Carine Joffre. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00959-1

Metabolic reprogramming in renal cancer: Events of a metabolic disease – Samik Chakraborty, Murugabaskar Balan, Akash Sabarwal, Toni K. Choueiri, Soumitro Pal. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000561

Recent advancements in therapeutic targeting of the Warburg effect in refractory ovarian cancer: A promise towards disease remission – Komal Tyagi, Supratim Mandal, Adhiraj Roy. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000603

Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy – Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000652

The immunological and metabolic landscape in primary and metastatic liver cancer – Xin Li, Pierluigi Ramadori, Dominik Pfister, Marco Seehawer, Lars Zender and Mathias Heikenwalder. https://www.nature.com/articles/s41568-021-00383-9

Exploring the therapeutic potential of mitochondrial uncouplers in cancer – Riya Shrestha, Edward Johnson, Frances L. Byrne. https://www.sciencedirect.com/science/article/pii/S2212877821000661


Comments


How the amino acid leucine activates the key cell-growth regulator mTOR – Tibor Vellai. https://www.nature.com/articles/d41586-021-01943-7

RAG-ulating mTORC1 with amino acids – Jenna L. Jewell. https://www.nature.com/articles/s41580-021-00378-2

Multiplexed suppression of TOR complex 1 induces autophagy during starvation – Tomoyuki Fukuda and Kazuhiro Shiozaki. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1938915

An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation – Ying Yang and Daniel J. Klionsky. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1959240

CD36 pumps fat to defang killer T cells in tumors – Manikandan Subramanian, Federica M. Marelli-Berg. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00320-X?dgcid=raven_jbs_etoc_email

Mechanisms of resistance to mitochondria-targeted therapy in pancreatic cancer – Stepana Boukalova, Zuzana Ezrova,  and Jiri Neuzil. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=5145010dcf&e=923b339f12

Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11high cancer cells – Xiaoguang Liu, and Boyi Gan. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=dde7eee63d&e=923b339f12

Excess Polyunsaturated Fatty Acids Induce Death in Acidic Cancer Cellshttps://cancerdiscovery.aacrjournals.org/content/11/8/1872.2

Metabolic mechanisms of medulloblastoma metastasis – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-021-00391-9

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