MetaboList – January 2022


Glucose metabolism


The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis – Youming Zhu, Lei Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00997-7

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1 – Tong Zhang, Linchong Sun, Yijie Hao, Caixia Suo, Shengqi Shen, Haoran Wei, Wenhao Ma, Pinggen Zhang, Ting Wang, Xuemei Gu, Shi-Ting Li, Zhaolin Chen, Ronghui Yan, Yi Zhang, Yongping Cai, Rongbin Zhou, Weidong Jia, Fang Huang, Ping Gao and Huafeng Zhang. https://www.nature.com/articles/s43018-021-00299-1

Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer – Nikita Sushentsev, Mary A. McLean and Ferdia A. Gallagher. https://www.nature.com/articles/s41467-022-28069-2

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells – Arin B. Aurora, Vishal Khivansara, Ashley Leach, Jennifer G. Gill, Misty Martin-Sandoval, Chendong Yang, Stacy Y. Kasitinon, Divya Bezwada, Alpaslan Tasdogan, Wen Gu, Thomas P. Mathews, Zhiyu Zhao, Ralph J. DeBerardinis, and Sean J. Morrison. https://www.pnas.org/content/119/6/e2120617119


Amino acids


Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors – Bo-Hyun Choi, Vipin Rawat, Jenny Högström, Philippa A. Burns, Kelly O. Conger, Mete Emir Ozgurses, Jaymin M. Patel, Tejas S. Mehta, Angelica Warren, Laura M. Selfors, Taru Muranen, Jonathan L. Coloff. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01793-9

Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions – Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00031-6


Lipids and cancer


Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity – Yanping Wang, Sungyong You, Shengchen Su, Austin Yeon, Eric M. Lo, Sungjin Kim, James L. Mohler, Michael R. Freeman and Hyung L. Kim. https://clincancerres.aacrjournals.org/content/28/2/414

MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation – Ting Zhang, Yanan Zhang, Jie Liu, Yan Ma, Qinong Ye, Xinlong Yan and Lihua Ding. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00276-3

C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer – Xiao-Zheng Liu, Anastasiia Rulina and Nils Halberg. https://www.nature.com/articles/s41467-021-27734-2

Lipidomic profiling of human serum enables detection of pancreatic cancer – Denise Wolrab, Robert Jirásko, Eva Cífková, Marcus Höring, Ding Mei, Michaela Chocholoušková, Ondřej Peterka, Jakub Idkowiak, Tereza Hrnčiarová, Ladislav Kuchař, Robert Ahrends, Radana Brumarová, David Friedecký, Gabriel Vivo-Truyols, Pavel Škrha, Jan Škrha, Radek Kučera, Bohuslav Melichar, Gerhard Liebisch, Ralph Burkhardt, Markus R. Wenk, Amaury Cazenave-Gassiot, Petr Karásek, Ivo Novotný, Kristína Greplová, Roman Hrstka and Michal Holčapek. https://www.nature.com/articles/s41467-021-27765-9

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis – Guangxi Wang, Mantang Qiu, Xudong Xing, Juntuo Zhou, Hantao Yao, Mingru Li, Rong Yin, Yan Hou, Yang Li, Shuli Pan, Yuqing Huang, Fan Yang, Fan Bai, Honggang Nie, Shuangshuang Di, Limei Guo, Zhu Meng, Jun Wang, Yuxin Yin. https://www.science.org/doi/abs/10.1126/scitranslmed.abk2756


Nucleotides


Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance – Gabriel Therizols, Zeina Bash-Imam, Baptiste Panthu, Christelle Machon, Anne Vincent, Julie Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, Maxime Garcia, Florian Laforêts, Virginie Marcel, Jihane Boubaker-Vitre, Marie-Ambre Monet, Céline Bouclier, Christophe Vanbelle, Guillaume Souahlia, Elise Berthel, Marie Alexandra Albaret, Hichem C. Mertani, Michel Prudhomme, Martin Bertrand, Alexandre David, Jean-Christophe Saurin, Philippe Bouvet, Eric Rivals, Théophile Ohlmann, Jérôme Guitton, Nicole Dalla Venezia, Julie Pannequin, Frédéric Catez and Jean-Jacques Diaz. https://www.nature.com/articles/s41467-021-27847-8


Mitochondria


Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism – Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex von Kriegsheim, Christian Frezza. https://elifesciences.org/articles/72593

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases – Esther P. Jane, Daniel R. Premkumar, Dhivyaa Rajasundaram, Swetha Thambireddy, Matthew C. Reslink, Sameer Agnihotri, Ian F. Pollack. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13025


Starvation


Leucine retention in lysosomes is regulated by starvation – Urmi Bandyopadhyay, Pavlina Todorova, Natalya N. Pavlova, Yuma Tada, Craig B. Thompson, Lydia W.S. Finley, and Michael Overholtzer. https://www.pnas.org/content/119/6/e2114912119

Endosomal cargo recycling mediated by Gpa1 and  Phosphatidylinositol-3-Kinase is inhibited by glucose starvation – Kamilla ME. Laidlaw, Katherine M. Paine, Daniel D. Bisinski, Grant Calder, Karen Hogg, Sophia Ahmed, Sally James, Peter J. O’Toole, and Chris MacDonald. https://www.molbiolcell.org/doi/10.1091/mbc.E21-04-0163?ai=25zg&ui=2oy6&af=T

The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress – Luyun Zou, Helen E Collins, Martin E Young, Jianhua Zhang, Adam R Wende, Victor M Darley-Usmar, John C Chatham.. https://www.frontiersin.org/articles/10.3389/fmolb.2021.780865/full


Hypoxia


Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions – Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00031-6

Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity – Brijesh Kumar, Adedeji K. Adebayo, Mayuri Prasad, Maegan L. Capitano, Ruizhong Wang, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Edward Simpson, Duojiao Chen, Yunlong Liu, Jeanne M. Schilder, Austyn B. Colter, Callista Maguire, Constance J. Temm, George Sandusky, Emma H. Doud, Aruna B. Wijeratne, Amber L. Mosley, Hal E. Broxmeyer, Harikrishna Nakshatri. https://www.science.org/doi/full/10.1126/sciadv.abh3375

Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers – Jialing Shen, Chunxue Yang, Misty Shuo Zhang, Don Wai-Ching Chin, For-Fan Chan, Cheuk-Ting Law, Gengchao Wang, Carol Lai-Hung Cheng, Mengnuo Chen, Rebecca Ting-Chi Wan, Mengjie Wu, Zhijian Kuang, Rakesh Sharma, Terence Kin Wah Lee, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00016-X


Cancer Immunometabolism


MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function – Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, Katherine L. Beier, Nowrin U. Chowdhury, Melissa M. Wolf, Arissa C. Young, Dalton L. Greenwood, Allison E. Sewell, Shailesh K. Shahi, Samantha N. Freedman, Alanna M. Cameron, Patrik Foerch, Tim Bourne, Juan C. Garcia-Canaveras, John Karijolich, Dawn C. Newcomb, Ashutosh K. Mangalam, Joshua D. Rabinowitz, Jeffrey C. Rathmell. https://www.cell.com/immunity/fulltext/S1074-7613(21)00448-9

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function – Lydia Dyck,  Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk, Roisin M. Loftus, Aaron Douglas, Janet McCormack, Bruce Moran, Michael Wilkinson, Evanna L. Mills, Michael Doughty, Aurelie Fabre, Helen Heneghan, Carel LeRoux, Andrew Hogan, Edward T. Chouchani, Donal O’Shea, Donal Brennan, Lydia Lynch. https://rupress.org/jem/article/219/3/e20210042/212992


Fasting


Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer – Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimondi, Darawan Rinchai, Gianmaria Frigè, Antonino Belfiore, Luca Lalli, Claudia Chiodoni, Valeria Cancila, Federica Zanardi, Arta Ajazi, Salvatore Cortellino, Viviana Vallacchi, Paola Squarcina, Agata Cova, Samantha Pesce, Paola Frati, Raghvendra Mall, Paola Antonia Corsetto, Angela Maria Rizzo, Cristina Ferraris, Secondo Folli, Marina Chiara Garassino, Giuseppe Capri, Giulia Bianchi, Mario Paolo Colombo, Saverio Minucci, Marco Foiani, Valter Daniel Longo, Giovanni Apolone, Valter Torri, Giancarlo Pruneri, Davide Bedognetti, Licia Rivoltini and Filippo de Braud. https://cancerdiscovery.aacrjournals.org/content/12/1/90

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism – Jelena Krstic, Isabel Reinisch, Katharina Schindlmaier, Markus Galhuber, Zina Riahi, Natascha Berger, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Helene Michenthaler, Christoph Nössing, Maria R. Depaoli, Jeta Ramadani-Muja, Sinem Usluer, Sarah Stryeck, Martin Pichler, Beate Rinner, Alexander J. A. Deutsch, Andreas Reinisch, Tobias Madl, Riccardo Zenezini Chiozzi, Albert J. R. Heck, Meritxell Huch, Roland Malli, Andreas Prokesch. https://www.science.org/doi/full/10.1126/sciadv.abh2635


Miscellaneous


Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors – Rupsa Datta, Sharanya Sivanand, Allison N. Lau, Logan V. Florek, Anna M. Barbeau, Jeffrey Wyckoff, Melissa C. Skala, Matthew G. Vander Heiden. https://www.science.org/doi/full/10.1126/sciadv.abg6383

Mitochondria shed their outer membrane in response to infection-induced stress – Xianhe Li, Julian Straub, Tânia Catarina Medeiros, Chahat Mehra, Fabian den Brave, Esra Peker, Ilian Atanassov, Katharina Stillger, Jonas Benjamin Michaelis, Emma Burbridge, Colin Adrain, Christian Münch, Jan Riemer, Thomas Becker, Lena F. Pernas. https://www.science.org/doi/abs/10.1126/science.abi4343


Reviews


Hypoxia-Inducible Factors in Cancer – Laura C. Kim, and M. Celeste Simon. https://cancerres.aacrjournals.org/content/82/2/195

Understanding the role of cysteine in ferroptosis: progress & paradoxes – Carson D. Poltorack, Scott J. Dixon. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15842

Amino Acid Metabolism in Cancer Drug Resistance – Hee-Chan Yoo and Jung-Min Han. https://doi.org/10.3390/cells11010140

Metabolic adaptation of lymphocytes in immunity and disease – Nicole M. Chapman, Hongbo Chi. https://www.cell.com/immunity/fulltext/S1074-7613(21)00548-3

The assembly, regulation and function of the mitochondrial respiratory chain – Irene Vercellino & Leonid A. Sazanov. https://www.nature.com/articles/s41580-021-00415-0

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma – Gabriel Alzial, Ophelie Renoult, François Paris, Catherine Gratas, Anne Clavreul and Claire Pecqueur. https://www.nature.com/articles/s41388-021-02056-1

Circulating metabolite homeostasis achieved through mass action – Xiaoxuan Li, Sheng Hui, Emily T. Mirek, William O. Jonsson, Tracy G. Anthony, Won Dong Lee, Xianfeng Zeng, Cholsoon Jang and Joshua D. Rabinowitz. https://www.nature.com/articles/s42255-021-00517-1

Built to last: lysosome remodeling and repair in health and disease – Roberto Zoncu, Rushika M.Perera. https://www.sciencedirect.com/science/article/pii/S0962892422000010

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap – Anna Halama and Karsten Suhre. https://www.mdpi.com/2072-6694/14/3/553

Cellular senescence: all roads lead to mitochondria – Hélène Martini, João F. Passos. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16361#.Yfhngl2bq4U


Comments


Metabolic transitions – Anna Dart. https://www.nature.com/articles/s41568-021-00438-x

Shifting acetylation during starvation – Wei Wong. https://www.science.org/doi/full/10.1126/scisignal.abo1065

Pentose phosphate pathway drives vascular maturation – Olga A. Cherepanova and Tatiana V. Byzova. https://www.nature.com/articles/s42255-021-00512-6

Tumor-Secreted Lipids Induce ER Stress Response to Polarize Macrophageshttps://cancerdiscovery.aacrjournals.org/content/12/1/OF5

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