MetaboList – March 2022


Glucose metabolism


A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine – Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi, Nadia Ducano, Alessia Mira, Manasvi S. Shah, Sylwia A. Stopka, Andrew J. Perciaccante, Claudio Isella, Daniel Moya-Rull, Marianela Vara-Messler, Silvia Giordano, Elena Maldi, Niyati Desai, Diane E. Capen, Enzo Medico, Murat Cetinbas, Ruslan I. Sadreyev, Dennis Brown, Miguel N. Rivera, Anna Sapino, David T. Breault, Nathalie Y. R. Agar and Raul Mostoslavsky. https://www.nature.com/articles/s41467-022-29085-y

MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer – Cannistraci, P. Hascoet, A. Ali, P. Mundra, N. W. Clarke, V. Pavet and R. Marais. https://www.nature.com/articles/s41388-022-02178-0

Aminopyridine analogs selectively target metastatic pancreatic cancer – Rana V. Smalling, Matthew E. Bechard, Jeff Duryea, Philip J. Kingsley, Evan R. Roberts, Lawrence J. Marnett, Daniel Bilbao, Shaun R. Stauffer and Oliver G. McDonald. https://www.nature.com/articles/s41388-022-02183-3

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma – Jia Li, Zhi-Qiang Hu, Song-Yang Yu, Li Mao; Zheng-Jun Zhou, Peng-Cheng Wang, Yu Gong; Sheng Su, Jian Zhou, Jia Fan, Shao-Lai Zhou, Xiao-Wu Huang. https://aacrjournals.org/cancerres/article-abstract/82/6/1055/682071


Amino acids


Tryptophan depletion results in tryptophan-to-phenylalanine substitutants – Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper and Reuven Agami. https://www.nature.com/articles/s41586-022-04499-2

For more papers on glutamine metabolism follow https://twitter.com/sreeparna_b

http://biomed.news/bims-glucam/2022-03-06

http://biomed.news/bims-glucam/2022-03-20

http://biomed.news/bims-glucam/2022-03-13

http://biomed.news/bims-glucam/2022-03-27


Lipid metabolism / acetate


Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia – Marissa Rashkovan, Robert Albero, Francesca Gianni, Pablo Perez-Duran, Hannah I. Miller, Adam L. Mackey, Elisabeth M. Paietta, Martin S. Tallman, Jacob M. Rowe, Mark R. Litzow, Peter H. Wiernik, Selina Luger, Maria Luisa Sulis, Rajesh K. Soni, Adolfo A. Ferrando. https://aacrjournals.org/cancerdiscovery/article/12/3/856/681883

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation – Lorela Ciraku, Zachary A. Bacigalupa, Jing Ju, Rebecca A. Moeller, Giang Le Minh, Rusia H. Lee, Michael D. Smith, Christina M. Ferrer, Sophie Trefely, Luke T. Izzo, Mary T. Doan, Wiktoria A. Gocal, Luca D’Agostino, Wenyin Shi, Joshua G. Jackson, Christos D. Katsetos, Kathryn E. Wellen, Nathaniel W. Snyder and Mauricio J. Reginato. https://www.nature.com/articles/s41388-022-02237-6


Nucleotides


Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex – Sharon Spizzichino, Dalila Boi, Giovanna Boumis, Roberta Lucchi, Francesca Romana Liberati, Davide Capelli, Roberta Montanari, Giorgio Pochetti, Roberta Piacentini, Giacomo Parisi, Alessio Paone, Serena Rinaldo, Roberto Contestabile, Angela Tramonti, Alessandro Paiardini, Giorgio Giardina, Francesca Cutruzzolà. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16248


Mitochondria and iron


CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH – Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00226-1

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death – Sylvain Garciaz, Andrew A. Guirguis, Sebastian Müller, Fiona C. Brown, Yih-Chih Chan, Ali Motazedian, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y.N. Lam, Tatiana Cañeque, Marian L. Burr, Véronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C.S. Huang, Andrew H. Wei, Kate McArthur, Raphaël Rodriguez, Mark A. Dawson. https://aacrjournals.org/cancerdiscovery/article/12/3/774/681925

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma – Julie Devin, Tatiana Cañeque, Yea-Lih Lin, Lucie Mondoulet, Jean-Luc Veyrune, Matthieu Abouladze, Elvira Garcia De Paco, Ouissem Karmous Gadacha, Guillaume Cartron, Philippe Pasero, Caroline Bret, Raphaël Rodriguez, Jerome Moreaux. https://aacrjournals.org/cancerres/article/82/6/998/682058

Mitochondrial respiration supports autophagy to provide stress resistance during quiescence – Silvia Magalhaes-Novais, Jan Blecha, Ravindra Naraine, Jana Mikesova, Pavel Abaffy, Alena Pecinova, Mirko Milosevic, Romana Bohuslavova, Jan Prochazka, Shawez Khan, Eliska Novotna, Radek Sindelka, Radek Machan, Mieke Dewerchin, Erik Vlcak, Joanna Kalucka, Sona Stemberkova Hubackova, Ales Benda, Jermaine Goveia, Tomas Mracek, Cyril Barinka, Peter Carmeliet, Jiri Neuzil, Katerina Rohlenova and Jakub Rohlena. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2038898

Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice – Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz-Barneo, G. R. Scott Budinger and Navdeep S. Chandel. https://www.nature.com/articles/s41598-022-09074-3


Starvation / nutrient sensing


Amino acid starvation‐induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance – Ye Chen, Xiao Wu, Jing Zhang, Guopin Pan, Xiaoyun Wang, Xiaosun Guo, Jianli Wang, Xiaopei Cui, Haiqing Gao, Mei Cheng, Jingwen Yang, Cheng Zhang, Fan Jiang. https://www.embopress.org/doi/full/10.15252/embr.202153373

Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation – Kamilla M. E. Laidlaw, Katherine M. Paine, Daniel D. Bisinski, Grant Calder, Karen Hogg, Sophia Ahmed, Sally James, Peter J. O’Toole, and Chris MacDonald. https://www.molbiolcell.org/doi/full/10.1091/mbc.E21-04-0163

Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer – Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao, Peng Gao. https://aacrjournals.org/cancerres/article-abstract/82/5/805/681782


Hypoxia


Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy – Jingyi Li, Tao Zhang, Tao Ren, Xiaoyu Liao, Yilong Hao, Je Sun Lim, Jong-Ho Lee, Mi Li, Jichun Shao and Rui Liu. https://www.nature.com/articles/s41467-022-28831-6


IDH


Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma – Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E. Olander, Ramzi Adil, Amaya Pankaj, Krishna Seshu Tummala, Vajira Weeresekara, Yuanli Zhen, Qibiao Wu, Meiqi Luo, William Shen, María García-Beccaria, Mirian Fernández-Vaquero, Christine Hudson, Sebastien Ronseaux, Yi Sun; Rodrigo Saad-Berreta, Russell W. Jenkins, Tong Wang, Mathias Heikenwälder, Cristina R. Ferrone, Lipika Goyal, Brandon Nicolay, Vikram Deshpande, Rahul M. Kohli, Hongwu Zheng, Robert T. Manguso, Nabeel Bardeesy. https://aacrjournals.org/cancerdiscovery/article/12/3/812/68192


Cancer Immunometabolism


Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses – Kunle Odunsi, Feng Qian, Amit A. Lugade, Han Yu, Melissa A. Geller, Steven P. Fling, Judith C. Kaiser, Andreanne M. Lacroix, Leonard D’Amico, Nirasha Ramchurren, Chihiro Morishima, Mary L. Disis, Lucas Dennis, Patrick Danaher, Sarah Warren, Van Anh Nguyen, Sudharshan Ravi, Takemasa Tsuji, Spencer Rosario, Wenjuan Zha, Alan Hutson, Song Liu, Shashikant Lele, Emese Zsiros, A. J. Robert McGray, Jessie Chiello, Richard Koya, Thinle Chodon, Carl D. Morrison, Vasanta Putluri, Nagireddy Putluri, Donald E. Mager, Rudiyanto Gunawan, Martin A. Cheever, Sebastiano Battaglia, Junko Matsuzaki. https://www.science.org/doi/abs/10.1126/scitranslmed.abg8402

Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma – Brooks P. Leitner, Kevin B. Givechian, Shyryn Ospanova, Aray Beisenbayeva, Katerina Politi and Rachel J. Perry. https://www.nature.com/articles/s41698-021-00248-2


Miscellaneous


Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis – Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras and Patricia Aspichueta. https://www.nature.com/articles/s41467-022-28749-z

Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer – Caner Yelek, Lionel Mignion, Adrien Paquot, Caroline Bouzin, Cyril Corbet, Giulio G Muccioli, Patrice D Cani, Bénédicte F Jordan. https://www.mdpi.com/2072-6694/14/3/562

Angiocrine polyamine production regulates adiposity – Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura Herrero, Rui Benedito, Pablo Garcia-Roves, Josep Vidal, Paul Cohen, Rubén Nogueiras, Marc Claret, Arkaitz Carracedo and Mariona Graupera. https://www.nature.com/articles/s42255-022-00544-6


Reviews


NRF2: KEAPing Tumors Protected – Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos. https://aacrjournals.org/cancerdiscovery/article/12/3/625/681905

Advancing Cancer Treatment by Targeting Glutamine Metabolism-A Roadmap – Anna Halama, Karsten Suhre. https://www.mdpi.com/2072-6694/14/3/553

Structural advances in sterol-sensing domain-containing proteins – Xuelan Wu, Renhong Yan, Pingping Cao, Hongwu Qian, Nieng Yan. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00274-7

Insulin and cancer: a tangled web – Brooks P. Leitner, Stephan Siebel, Ngozi D. Akingbesote, Xinyi Zhang, Rachel J. Perry. https://portlandpress.com/biochemj/article/479/5/583/230979

The central moTOR of metabolism – Judith Simcox, Dudley W. Lamming. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00126-5


Comments


IDH1 Inhibition Reawakens the Immune Response against Cholangiocarcinoma – Yan Zhu, Lawrence N. Kwong. https://aacrjournals.org/cancerdiscovery/article/12/3/604/681915

MTHFD2, metabolic mastermind of CD4+ T cell destiny – Victoire Gouirand and Michael D. Rosenblum. https://www.science.org/doi/full/10.1126/sciimmunol.abo6765

Metabolic Adaptations Alter Metastatic Fitness in Brain-Tropic Breast Cancer. https://aacrjournals.org/cancerdiscovery/article/12/3/OF5/681892

CAR T-cell Efficacy in Solid Tumors Is Affected by N-glycosylation. https://aacrjournals.org/cancerdiscovery/article/12/3/598/681906

Obesity and antitumor immunity – John F. Foley. https://www.science.org/doi/full/10.1126/scisignal.abq0080

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