MetaboList – April 2022


Ketones / Lipids / Acetate


β-Hydroxybutyrate suppresses colorectal cancer – Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Hélène C. Descamps, Lenka Dohnalová, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss and Maayan Levy. https://www.nature.com/articles/s41586-022-04649-6

Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression – Victoire Gouirand, Tristan Gicquel, Evan C Lien, Emilie Jaune-Pons,  Quentin Da Costa,  Pascal Finetti,  Elodie Metay, Camille Duluc, Jared R Mayers, Stephane Audebert,  Luc Camoin, Laurence Borge, Marion Rubis, Julie Leca, Jeremy Nigri, François Bertucci, Nelson Dusetti, Juan Lucio Iovanna, Richard Tomasini, Ghislain Bidaut, Fabienne Guillaumond, Matthew G Vander Heiden, Sophie Vasseur. https://www.embopress.org/doi/abs/10.15252/embj.2021110466

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer – Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman and Afshin Samali. https://www.nature.com/articles/s41467-022-30159-0

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration – Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida, Toshio Suda. https://www.embopress.org/doi/abs/10.15252/embj.2021109463

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma – Min Tang, Xin Dong […] Ya Cao. https://www.nature.com/articles/s41419-022-04730-y

Altered propionate metabolism contributes to tumour progression and aggressiveness – Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt and John Blenis. https://www.nature.com/articles/s42255-022-00553-5

Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer – Luigi Ippolito, Giuseppina Comito, Matteo Parri, Marta Iozzo, Assia Duatti, Francesca Virgilio, Nicla Lorito, Marina Bacci, Elisa Pardella, Giada Sandrini, Francesca Bianchini, Roberta Damiano, Lavinia Ferrone, Giancarlo la Marca, Sergio Serni, Pietro Spatafora, Carlo V. Catapano, Andrea Morandi, Elisa Giannoni, Paola Chiarugi. https://aacrjournals.org/cancerres/article-abstract/82/7/1267/694059


Mitochondria


Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma – Xin Ge, Mengdie Li, Jianxing Yin, Zhumei Shi, Yao Fu, Ningwei Zhao, Hongshan Chen, Longxiyu Meng, Xinjian Li, Zhibin Hu, Xiaozhi Zhao, Hongqian Guo, Xu Qian. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00105-8

Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with SDHB gene mutation – Takao Kamai, Satoshi Murakami, Kyoko Arai, Daisaku Nishihara, Toshitaka Uematsu, Kazuyuki Ishida, Toshiki Kijima. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09415-5

Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells – Jin-Song Yan, Meng-Ying Yang, Xue-Hong Zhang, Chen-Hui Luo, Cheng-Kan Du, Yue Jiang, Xuan-Jia Dong, Zhang-Man Wang, Li-Xue Yang, Yi-Dong Li, Li Xia and Ying Lu. https://www.nature.com/articles/s41419-022-04842-5

PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer – Carmen Ghilardi, Catarina Moreira-Barbosa, Laura Brunelli, Paola Ostano, Nicolò Panini, Monica Lupi, Alessia Anastasia, Fabio Fiordaliso, Monica Salio, Laura Formenti, Massimo Russo, Edoardo Arrigoni, Ferdinando Chiaradonna, Giovanna Chiorino, Giulio Draetta, Joseph R. Marszalek, Christopher P. Vellano, Roberta Pastorelli, MariaRosa Bani, Alessandra Decio, Raffaella Giavazzi. https://aacrjournals.org/cancerres/article/82/7/1423/694053

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer – Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji. https://www.sciencedirect.com/science/article/pii/S2212877822000382


Starvation / AMPK


Carbon starvation, senescence and specific mitochondrial stresses, but not nitrogen starvation and general stresses, are major triggers for mitophagy in Arabidopsis – Sylwia M. Kacprzak and Olivier Van Aken. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2054039

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis – Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00525-3


Hypoxia


NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment – Irene Bertolini, Michela Perego, Jagadish C. Ghosh, Andrew V. Kossenkov and Dario C. Altieri. https://www.nature.com/articles/s41388-022-02280-3

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation – Koh Nakayama, Sigal Shachar, Elizabeth H. Finn, Hiroyuki Sato, AkihiroHirakawa, and Tom Misteli. https://www.molbiolcell.org/doi/10.1091/mbc.E21-11-0593?ai=25zg&ui=2oy6&af=T

Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress – Sandhya Chipurupalli, Raja Ganesan, Giulia Martini, Luigi Mele, Alessio Reggio, Marianna Esposito, Elango Kannan, Vigneshwaran Namasivayam, Paolo Grumati, Vincenzo Desiderio and Nirmal Robinson. https://www.nature.com/articles/s41419-022-04813-w


Cancer Immunometabolism


Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer – Sarah A. Best, Patrick M. Gubser, Shalini Sethumadhavan,  Ariena Kersbergen., Yashira L. Negrón Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L. Garnham, Jackson A. McDonald, Clare E. Weeden, Dovile Anderson, David Pirman, Thomas P. Roddy, Darren J. Creek, Axel Kallies, Gillian Kingsbury, Kate D. Sutherland. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00130-9

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells – Jia Xiong, Jia He, Jun Zhu, Jiongli Pan, Weijie Liao, Hongying Ye, Haofei Wang, Yinjing Song, Yue Du, Bijun Cui, Maoguang Xue, Wanling Zheng, Xiangxing Kong, Kai Jiang, Kefeng Ding, Lihua Lai, Qingqing Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00207-6

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function – Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martín, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00127-9

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer – Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang. https://aacrjournals.org/cancerres/article-abstract/82/8/1575/694351

Metabolism drives macrophage heterogeneity in the tumor microenvironment – Shasha Li, Jiali Yu, Amanda Huber, Ilona Kryczek, Zhuwen Wang, Long Jiang, Xiong Li, Wan Du, Gaopeng Li, Shuang Wei, Linda Vatan, Wojciech Szeliga, Arul M. Chinnaiyan, Michael D. Green, Marcin Cieslik, Weiping Zou. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00357-6

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy – Lupeng Ye, Jonathan J. Park, Lei Peng, Quanjun Yang, Ryan D. Chow, Matthew B. Dong, Stanley Z. Lam, Jianjian Guo, Erting Tang, Yueqi Zhang, Guangchuan Wang, Xiaoyun Dai, Yaying Du, Hyunu R. Kim, Hanbing Cao, Youssef Errami, Paul Clark, Alexey Bersenev, Ruth R. Montgomery, Sidi Chen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00053-5

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 – Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00036-8


Glucose metabolism/lactate


Hexokinase 1 cellular localization regulates the metabolic fate of glucose – Adam De Jesus, Farnaz Keyhani-Nejad, Carolina M. Pusec, Lauren Goodman, Justin A. Geier, Joshua S. Stoolman, Paulina J. Stanczyk, Tivoli Nguyen, Kai Xu, Krishna V. Suresh, Yihan Chen, Arianne E. Rodriguez, Jason S. Shapiro, Hsiang-Chun Chang, Chunlei Chen, Kriti P. Shah, Issam Ben-Sahra, Brian T. Layden, Navdeep S. Chandel, Samuel E. Weinberg, Hossein Ardehali. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00166-6

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway – Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel. https://elifesciences.org/articles/69223

NEDD9 sustains hexokinase expression to promote glycolysis – Alexander Y. Deneka, Anna S. Nikonova, Hyung-Ok Lee, Warren D. Kruger and Erica A. Golemis. https://www.nature.com/articles/s41389-022-00391-w

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth – Chunwan Lu, Dafeng Yang, John D. Klement, Yolonda L. Colson, Nicholas H. Oberlies, Cedric J. Pearce, Aaron H. Colby, Mark W. Grinstaff, Zhuoqi Liu, Huidong Shi, Han-Fei Ding and Kebin Liu. https://www.nature.com/articles/s41388-022-02283-0

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis – Xuetian Yue, Jianming Wang, Chun-yuan Chang, Juan Liu, Xue Yang, Fan Zhou, Xia Qiu, Vrushank Bhatt, Jessie Yanxiang Guo, Xiaoyang Su, Lanjing Zhang, Zhaohui Feng and Wenwei Hu. https://www.nature.com/articles/s41419-022-04820-x

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells – Vivian Morris, Dahai Wang, Zhiheng Li, William Marion, Travis Hughes, Patricia Sousa, Taku Harada, Shannan Ho Sui, Sergey Naumenko, Jérémie Kalfon, Prerana Sensharma, Marcelo Falchetti, Renan Vinicius da Silva, Tito Candelli, Pauline Schneider, Thanasis Margaritis, Frank C.P. Holstege, Yana Pikman, Marian Harris, Ronald W. Stam, Stuart H. Orkin, Angela N. Koehler, Alex K. Shalek, Trista E. North, Maxim Pimkin, George Q. Daley, Edroaldo Lummertz da Rocha, R. Grant Rowe. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00516-2

A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma – Jennifer G. Gill, Samantha N. Leef, Vijayashree Ramesh, Misty S. Martin-Sandoval, Aparna D. Rao, Lindsey West, Sarah Muh, Wen Gu, Zhiyu Zhao, Gregory A. Hosler, Travis W. Vandergriff, Alison B. Durham, Thomas P. Mathews, Arin B. Aurora. https://aacrjournals.org/cancerres/article-abstract/82/7/1251/694035

A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer – Emanuela Dylgjeri, Vishal Kothari, Ayesha A. Shafi, Galina Semenova, Peter T. Gallagher, Yi F. Guan, Angel Pang, Jonathan F. Goodwin, Swati Irani, Jennifer J. McCann, Amy C. Mandigo, Saswati Chand, Christopher M. McNair, Irina Vasilevskaya, Matthew J. Schiewer, Costas D. Lallas,  Peter A. McCue, Leonard G. Gomella, Erin L. Seifert, Jason S. Carroll, Lisa M. Butler, Jeff Holst, William K. Kelly, Karen E. Knudsen. https://aacrjournals.org/clincancerres/article/28/7/1446/682199/

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability – Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante and Jan Jacob Schuringa. https://www.nature.com/articles/s41467-022-29639-0


Amino acid metabolism


MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis – Hamed Alborzinia, Andrés F. Flórez, Sina Kreth, Lena M. Brückner, Umut Yildiz, Moritz Gartlgruber, Dorett. Odoni, Gernot Poschet, Karolina Garbowicz, Chunxuan Shao, Corinna Klein, Jasmin Meier, Petra Zeisberger, Michal Nadler-Holly, Matthias Ziehm, Franziska Paul, Jürgen Burhenne, Emma Bell, Marjan Shaikhkarami, Roberto Würth, Sabine A. Stainczyk, Elisa M. Wecht, Jochen Kreth, Michael Büttner, Naveed Ishaque, Matthias Schlesner, Barbara Nicke, Carlo Stresemann, María Llamazares-Prada, Jan H. Reiling, Matthias Fischer, Ido Amit, Matthias Selbach, Carl Herrmann, Stefan Wölfl, Kai-Oliver Henrich, Thomas Höfer, Andreas Trumpp and Frank Westermann. https://www.nature.com/articles/s43018-022-00355-4

Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial – Funda Meric-Bernstam, Nizar M. Tannir, Othon Iliopoulos, Richard J. Lee, Melinda L. Telli, Alice C. Fan, Angela DeMichele, Naomi B. Haas, Manish R. Patel, James J. Harding, Martin H. Voss, Taofeek K. Owonikoko, Bradley Carthon, Ramaprasad Srinivasan, Johanna C. Bendell, Yonchu Jenkins, Sam H. Whiting, Keith Orford, Mark K. Bennett, Todd M. Bauer. https://aacrjournals.org/clincancerres/article-abstract/28/8/1540/694145

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy – Mario R. Fernandez, Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, rank C. Dorsey, Min Liu, Meredith A. Steeves, Andrea Ballabio, Alexandar Tzankov, Zhihua Chen, John M. Koomen, Anders E. Berglund, John L. Cleveland. https://aacrjournals.org/cancerres/article/82/7/1234/694032

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML – Chang Liu, Waiyi Zou, Danian Nie, Shuyi Li, Chen Duan, Min Zhou, Peilong Lai, Shengyong Yang, Sen Ji, Yangqiu Li, Mei Mei, Shilai Bao, Yanli Jin, Jingxuan Pan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00131-0

Characterization of metabolic alterations of Chronic Lymphocytic Leukemia in the lymph node microenvironment – Zhenghao Chen,  Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, Michel van Weeghel, Dean Bryant, Jaco A. C. van Bruggen, F. S. Peters, Jeffrey C. Rathmell, G.J.W. van der Windt, Arnon P Kater, Graham Packham, Eric Eldering. https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2021013990/485126


Miscellaneous


Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia – Elisabeth Wyart, Myriam Y Hsu, Roberta Sartori, Erica Mina, Valentina Rausch, Elisa S Pierobon, Mariarosa Mezzanotte, Camilla Pezzini, Laure B Bindels, Andrea Lauria, Fabio Penna, Emilio Hirsch, Miriam Martini, Massimiliano Mazzone, Antonella Roetto, Simonetta Geninatti Crich, Hans Prenen, Marco Sandri, Alessio Menga, Paolo E Porporato. https://www.embopress.org/doi/full/10.15252/embr.202153746

Integrative metabolomic characterization identifies plasma metabolomic signature in the diagnosis of papillary thyroid cancer – Shuang Yu, Changan Liu, Yingtong Hou, Jie Li, Zhuming Guo, Xinwen Chen, Luyao Zhang, Sui Peng, Shubin Hong, Lixia Xu, Xiaoxing Li, Rengyun Liu, Shuwei Chen, Bin Li, Zongpeng Weng, Yanbing Li, Weiming Lv, Jun Yu and Haipeng Xiao. https://www.nature.com/articles/s41388-022-02254-5

Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms – James R. Larkin, Susan Anthony, Vanessa A. Johanssen, Tianrong Yeo, Megan Sealey, Abi G. Yates, Claire Friedemann Smith, Timothy D.W. Claridge, Brian D. Nicholson, Julie-Ann Moreland, Fergus Gleeson, Nicola R. Sibson, Daniel C. Anthony, Fay Probert. https://aacrjournals.org/clincancerres/article/28/8/1651/694157

Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy – Marta Mascaraque-Checa, María Gallego-Rentero, Jimena Nicolás-Morala, Mikel Portillo-Esnaola, José M. Cuezva, Salvador González, Yolanda Gilaberte, Ángeles Juarranz. https://www.sciencedirect.com/science/article/pii/S2212877822000655

An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition – Maurizio Ragni, Chiara Ruocco, Laura Tedesco, Michele O.Carruba, Alessandra Valerio, Enzo Nisoli. https://www.sciencedirect.com/science/article/pii/S2212877822000473

Atg6 promotes organismal health by suppression of cell stress and inflammation – James L. Shen, Johnna Doherty, Elizabeth Allen, Tina M. Fortier and Eric H. Baehrecke. https://www.nature.com/articles/s41418-022-01014-y


Nucleotides and NADPH


Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity – Amy Tarangelo, Jason Rodencal, Joon Tae Kim, Leslie Magtanong, Jonathan Z Long and Scott J Dixon. https://www.life-science-alliance.org/content/5/4/e202101157.abstract

NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells – Chiqi Chen, Xiaoyun Lai, Yaping Zhang, Li Xie, Zhuo Yu, Sijia Dan, Yu Jiang, Weicai Chen, Ligen Liu, Yi Yang, Dan Huang, Yuzheng Zhao, Junke Zheng. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00355-2

MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers – Omar Alhalabi, Jianfeng Chen, …, and Jianjun Gao. https://www.nature.com/articles/s41467-022-29397-z


Reviews


The two sides of creatine in cancer – Liwen Zhang, Pengcheng Bu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00230-0

Regulation of chromatin accessibility by hypoxia and HIF – Michael Batie; Julianty Frost; Dilem Shakir; Sonia Rocha. https://portlandpress.com/biochemj/article/479/6/767/230989

Glutamine, MTOR and autophagy: a multiconnection relationship – Clément Bodineau, Mercedes Tomé, Piedad del Socorro Murdoch and Raúl V. Durán. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2062875

Emerging signaling mediators in the anorexia–cachexia syndrome of cancer – Erin E. Talbert, Denis C. Guttridge. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00010-3


Comments


Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival – Dohun Kim, Gerta Hoxhaj. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00375-6

Circling back to PTEN: Fumarate inhibits canonical tumor suppressor – Sally E. Claridge, Benjamin D. Hopkins. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00222-2

Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness – Emily J. Kay and Sara Zanivan. https://www.nature.com/articles/s42255-022-00540-w

Alternative cycle for citrate – Paulina Strzyz. https://www.nature.com/articles/s41580-022-00475-w

Restored Ketosis Drives Anticancer Immunity in Colorectal Cancer – David C. Montrose, Lorenzo Galluzzi. https://aacrjournals.org/cancerres/article-abstract/82/8/1464/694347

In an Era of ctDNA, Is Metabolomics the New Kid on the Block? – Brian A. Van Tine, Costas A. Lyssiotis. https://aacrjournals.org/clincancerres/article-abstract/28/8/1477/694166

Cell scientist to watch – Lydia Finley. https://journals.biologists.com/jcs/article/135/7/jcs260023/274953

Dying cell-derived SAM switches off inflammation – Roel P. H. De Maeyer and Derek W. Gilroy. https://www.nature.com/articles/s42255-022-00556-2

A FAsT contribution: Adipocytes rewire their metabolism to acquire immune functions – Takumi Kobayashi, Dirk Brenner. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00134-6?


Profile of Ana Maria Cuervo  – Sandeep Ravindran. https://www.pnas.org/doi/10.1073/pnas.2204524119?ai=aqle&ui=c8ih&af=T

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