MetaboList – August 2022


Glucose/Warburg metabolism


Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells – Yahui Wang, Ethan Stancliffe, Ronald Fowle-Grider, Rencheng Wang, Cheng Wang, Michaela Schwaiger-Haber, Leah P. Shriver, Gary J. Patti. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00703-1 Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis – Dan He, Huijin Feng, Belen Sundberg, Jiaxing Yang, Justin Powers, Alec H. Christian, John E. Wilkinson, Cian Monnin, Daina Avizonis, Craig J. Thomas, Richard A. Friedman, Michael D. Kluger, Michael A. Hollingsworth, Paul M. Grandgenett, Kelsey A. Klute, F. Dean Toste, Christopher J. Chang, Iok In Christine Chio. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00541-X RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1 – Yifei Pei, Shuning Lv, Yong Shi, Jingwen Jia, Mengru Ma, Hailong Han, Rongying Zhang, Jieqiong Tan and Xinjun Zhang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2114271 An Integrated Proteomic and Glycoproteomic Investigation Reveals Alterations in the N-Glycoproteomic Network Induced by 2-Deoxy-D-Glucose in Colorectal Cancer Cells – Cheng Ma, Hong-Yuan Tsai, Qi Zhang, Lakmini Senavirathna, Lian Li, Lih-Shen Chin, Ru Chen and Sheng Pan. https://www.mdpi.com/1422-0067/23/15/8251/htm#app1-ijms-23-08251 PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway – Min Liu, Runmei Li, Min Wang, Ting Liu, Qiuru Zhou, Dong Zhang, Jian Wang, Meng Shen, Xiubao Ren, Qian Sun. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13259 Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate – John N. Koberstein, Melissa L. Stewart, Chadwick B. Smith, Andrei I. Tarasov, Frances M. Ashcroft, Philip J. S. Stork and Richard H. Goodman. https://www.pnas.org/doi/10.1073/pnas.2204407119

Lipid/NADPH sensing and metabolism


Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1 – Hijai R. Shin, Y. Rose Citron, Lei Wang, Laura Tribouillard, Claire S. Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson4, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, Rushika M. Perera, Eunyong Park, Douglas F. Covey, Mathieu Laplante, Alex S. Evers, Roberto Zoncu. https://www.science.org/doi/10.1126/science.abg6621 Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma – Fangzhou Liu, Tian Tian, Zhen Zhang, Shanshan Xie, Jiecheng Yang, Linyu Zhu, Wen Wang, Chengyu Shi, Lingjie Sang, Kaiqiang Guo, Zuozhen Yang, Lei Qu, Xiangrui Liu, Jian Liu, Qingfeng Yan, Huai-qiang Ju, Wenqi Wang, Hai-long Piao, Jianzhong Shao, Tianhua Zhou and Aifu Lin. https://www.nature.com/articles/s42255-022-00616-7 Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells – Yuying Tan, Junjie Li, Guangyuan Zhao, Kai-Chih Huang, Horacio Cardenas, Yinu Wang, Daniela Matei and Ji-Xin Cheng. https://www.nature.com/articles/s41467-022-32101-w The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis – Kha The Nguyen, Sang-Hyeon Mun, Jihye Yang, Jongeun Lee, Ok-Hee Seok, Eunjeong Kim, Dasom Kim, So Young An, Dong-Young Seo, Jeong-Yong Suh, Yoontae Lee and Cheol-Sang Hwang. https://www.nature.com/articles/s41556-022-00973-1

Nutrient sensing/mTOR/AMPK


Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly – Edoardo Ratto, S. Roy Chowdhury, Nora S. Siefert, Martin Schneider, Marten Wittmann, Dominic Helm and Wilhelm Palm. https://www.nature.com/articles/s41467-022-32515-6 Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment – Yan Tang, David J. Kwiatkowski and Elizabeth P. Henske. https://www.nature.com/articles/s41467-022-32673-7 The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations – Tianzhuo Wang, Huiying Guo, Qianchen Li, Weijie Wu, Miao Yu, Lei Zhang, Cuicui Li, Jiagui Song, Zhenbin Wang, Jing Zhang, Yan Tang, Lei Kang, Hongquan Zhang, Jun Zhan https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01074-9 Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells – Younghwan Lee, Yoko Itahana, Choon Chen Ong, Koji Itahana. https://journals.biologists.com/jcs/article-abstract/135/15/jcs259090/276257 Manganese is a physiologically relevant TORC1 activator in yeast and mammals – Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, Marie-Pierre Péli-Gulli, Elisabet Fernández-García, Mercedes Tomé, Néstor García-Rodríguez, Raúl V Durán, Claudio De Virgilio Is a corresponding author, Ralf Erik Wellinger. https://elifesciences.org/articles/80497 DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting – Christopher J. Yuskaitis, Jinita B. Modasia, Sandra Schrötter, Leigh-Ana Rossitto, Karenna J. Groff, Christopher Morici, Divakar S. Mithal, Ram P. Chakrabarty, Navdeep S. Chandel, Brendan D. Manning, Mustafa Sahin. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01098-1 PTEN inhibits AMPK to control collective migration – Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense and Sandrine Etienne-Manneville. https://www.nature.com/articles/s41467-022-31842-y

Nucleotide metabolism and sensing


Nucleotide imbalance decouples cell growth from cell proliferation – Frances F. Diehl, Teemu P. Miettinen, Ryan Elbashir, Christopher S. Nabel, Alicia M. Darnell, Brian T. Do, Scott R. Manalis, Caroline A. Lewis and Matthew G. Vander Heiden. https://www.nature.com/articles/s41556-022-00965-1 The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis – Eunus S. Ali, Anna Lipońska, Brendan P. O’Hara, David R. Amici, Michael D. Torno, Peng Gao, John M. Asara, Mee-Ngan F. Yap, Marc L. Mendillo, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00544-5 SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis – Erica Pranzini, Elisa Pardella, Livio Muccillo, Angela Leo, Ilaria Nesi, Alice Santi, Matteo Parri, Tong Zhang, Alejandro Huerta Uribe, Tiziano Lottini, Lina Sabatino, Anna Caselli, Annarosa Arcangeli, Giovanni Raugei, Vittorio Colantuoni, Paolo Cirri, Paola Chiarugi, Oliver D.K. Maddocks, Paolo Paoli, Maria Letizia Taddei. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01050-6 Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth – Meng Yuan, Bo Tu, Hengchao Li, Huanhuan Pang, Nan Zhang, Minghe Fan, Jingru Bai, Wei Wang, Zhaoqi Shu, Christopher C. DuFort, Sihan Huo, Jie Zhai, Ke Yao, Lina Wang, Haoqiang Ying, Wei-Guo Zhu, Deliang Fu, Zeping Hu and Ying Zhao. https://www.nature.com/articles/s43018-022-00426-

Amino acid metabolism


Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers – Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniela Annibali and Frédéric Amant. https://www.nature.com/articles/s41467-022-32272-6 Glutamine addiction promotes glucose oxidation in triple-negative breast cancer – Lake-Ee Quek, Michelle van Geldermalsen, Yi Fang Guan, Kanu Wahi, Chelsea Mayoh, Seher Balaban, Angel Pang, Qian Wang, Mark J. Cowley, Kristin K. Brown, Nigel Turner, Andrew J. Hoy and Jeff Holst. https://www.nature.com/articles/s41388-022-02408-5 Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context – Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis. https://elifesciences.org/articles/73245 I also recommend the selection: “Glutamine cancer metabolism” by Sreeparna Banerjee – Sign up at http://biomed.news/reports

Mitochondria / heme / hypoxia


Operation of a TCA cycle subnetwork in the mammalian nucleus – Eleni Kafkia, Amparo Andres-Pons, Kerstin Ganter, Markus Seiler, Tom S. Smith, Anna Andrejeva, Paula Jouhten, Filipa Pereira, Catarina Franco, Anna Kuroshchenkova, Sergio Leone, Ritwick Sawarkar, Rebecca Boston, James Thaventhiran, Judith B. Zaugg1, Kathryn S. Lilley, Christophe Lancrin, Martin Beck, Kiran Raosaheb Patil. https://www.science.org/doi/10.1126/sciadv.abq5206 In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors – Panayotis Pachnis, Zheng Wu, Brandon Faubert, Alpaslan Tasdogan, Wen Gu, Spencer Shelton, Ashley Solmonson, Aparna D. Rao, Akash K. Kaushik,  Thomas J. Rogers, Jessalyn M. Ubellacker, Collette A. LaVigne, Chendong Yang1, Bookyung Ko1, Vijayashree Ramesh, Jessica Sudderth, Lauren G. Zacharias,  Misty S. Martin-Sandoval1, Duyen Do1, Thomas P. Mathews1, Zhiyu Zhao, Prashant Mishra, Sean J. Morrison, Ralph J. DeBerardinis. https://www.science.org/doi/10.1126/sciadv.abn9550 Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction – Isabelle Adant, Matthew Bird, Bram Decru, Petra Windmolders, Marie Wallays, Peter de Witte, Daisy Rymen, Peter Witters, Pieter Vermeersch, David Cassiman, Bart Ghesquière. https://www.sciencedirect.com/science/article/pii/S2212877822001065 Glutamine metabolism mediates sensitivity to respiratory complex II inhibition in acute myeloid leukemia – Alessia Roma,  Matthew Tcheng; Nawaz Ahmed; Sarah Walker; Preethi Jayanth; Mark D. Minden; Kristin Hope; Praveen P. Nekkar Rao; Jessica Luc; Andrew C. Doxey; Julie A. Reisz; Rachel Culp-Hill; Angelo D’Alessandro; Paul A. Spagnuolo. https://aacrjournals.org/mcr/article-abstract/doi/10.1158/1541-7786.MCR-21-1032/708293 Hypoxia‐induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R – Seung Hee Seo, Soo-Yeon Hwang, Seohui Hwang, Sunjung Han, Hyojin Park, Yun-Sil Lee, Seung Bae Rho, Youngjoo Kwon https://www.embopress.org/doi/full/10.15252/embr.202152977 Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability – Gokhan Unlu, Benjamin Prizer, Ranya Erdal, Hsi-Wen Yeh, Erol C. Bayraktar, Kıvanç Birsoy. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00491-9 I also recommend the selection: “Mitochondrial metabolism in cancer” by Christian Frezza. Sign up at http://biomed.news/reports

Starvation/the UPR/celll death


Sublethal cytochrome c release generates drug-tolerant persister cells – Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W.G. Tait, Colin R. Goding, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(22)00978-3 Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells – Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas and Jose C. Perales. https://www.nature.com/articles/s41419-022-05177-x GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment – Rindert Missiaen, Nicole M. Anderson, Laura C. Kim, Bailey Nance, Michelle Burrows, Nicolas Skuli, Madeleine Carens, Romain Riscal, An Steensels, Fuming Li, M. Celeste Simon. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00230-3 Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector – Ruizhi Li, Kristin F. Wilson and Richard A. Cerione. https://www.nature.com/articles/s41420-022-01156-5 Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling under leucine deprivation – Junki Yamamura, Sihui Ma, Huijuan Jia and Hisanori Kato. https://www.frontiersin.org/articles/10.3389/fnut.2022.965771/full The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages – Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R. Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E. Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V. Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L. Oliveira, Marco Constante, Manuela M. Santos, Carlos R. Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho and Soroush Tahmasebi. https://www.pnas.org/doi/10.1073/pnas.2121251119 Supramolecular assembly of GSK3α as a cellular response to amino acid starvation – Laura Hinze, Sabine Schreek, Andre Zeug, Nurul Khalida Ibrahim, Beate Fehlhaber, Lorent Loxha, Buesra Cinar, Evgeni Ponimaskin, James Degar, Connor McGuckin, Gabriela Chiosis, Cornelia Eckert, Gunnar Cario, Beat Bornhauser, Jean-Pierre Bourquin, Martin Stanulla, Alejandro Gutierrez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00492-0 FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma – Junjun Li, Yongchang Zhang, Li Wang, Min Li, Jianbo Yang, Pan Chen, Jie Zhu, Xiayu Li, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, James B. McCarthy, Bo Xiang and Mei Yi. https://www.nature.com/articles/s41419-022-05150-8 I also recommend the selection: “Unfolded protein response” by Susan Logue. Sign up at http://biomed.news/reports

Cancer Immunometabolism


Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells – Ilaria Elia, Jared H. Rowe, Sheila Johnson, Shakchhi Joshi, Giulia Notarangelo, Kiran Kurmi, Sarah Weiss, Gordon J. Freeman, Arlene H. Sharpe, Marcia C. Haigis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00228-5 TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells – Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00538-X Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects [in mice] – Salvatore Cortellino, Alessandro Raveane, Claudia Chiodoni, Gloria Delfanti, Federica Pisati, Vanessa Spagnolo, Euplio Visco, Giuseppe Fragale, Federica Ferrante, Serena Magni, Fabio Iannelli, Federica Zanardi, Giulia Casorati, Francesco Bertolini, Paolo Dellabona, Mario P. Colombo, Claudio Tripodo, Valter D. Longo. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01074-9 Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response – Kazi Mokim Ahmed, Ratna Veeramachaneni, Defeng Deng, Nagireddy Putluri, Vasanta Putluri, Maria F Cardenas, David A Wheeler, William K Decker, Andy I Frederick, Sawad Kazi, Andrew G Sikora, Vlad C Sandulache and Mitchell J Frederick. https://jitc.bmj.com/content/10/8/e004752 I also recommend the selection: “Immunometabolism of infection, cancer and immune-mediated disease” by Dylan Ryan. Sign up at http://biomed.news/reports

IDH


Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells – Emily Gruber, Joan So, Alexander C. Lewis, Rheana Franich, Rachel Cole, Luciano G. Martelotto, Amy J. Rogers, Eva Vidacs, Peter Fraser, Kym Stanley, Lisa Jones, Anna Trigos, Niko Thio, Jason Li, Brandon Nicolay, Scott Daigle, Adriana E. Tron, Marc L. Hyer, Jake Shortt, Ricky W. Johnstone, Lev M. Kats. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00995-0 Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors – Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud and Christopher J. Schofield. https://www.nature.com/articles/s41467-022-32436-4
Miscellaneous
MYC sensitises cells to apoptosis by driving energetic demand – Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen and Andrew J. Finch Show fewer authors. https://www.nature.com/articles/s41467-022-32368-z Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures – Fariba Roshanzamir, Jonathan L. Robinson, Daniel Cook, Mohammad Hossein Karimi-Jafari and Jens Nielsen. https://www.pnas.org/doi/10.1073/pnas.2205456119 Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer – Rui An, Haitao Yu, Yanzhong Wang, Jie Lu, Yuzhen Gao, Xinyou Xie and Jun Zhang. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00289-6 Other recommended reports at http://biomed.news/reportsMetabolism and paracrine crosstalk between cancer and the organism” by Cristina Muñoz Pinedo “Metabolism of non-small cell lung carcinoma“, by the Muñoz Pinedo/Nadal lab “Metabolic-dependent epigenetic reprogramming in differentiation and disease“, by Alessandro Carrer.

Reviews


A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements – Ajit S. Divakaruni and Martin Jastroch. https://www.nature.com/articles/s42255-022-00619-4 Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance – Sophie Vasseur and Fabienne Guillaumond. https://www.nature.com/articles/s41389-022-00420-8 Regulation of gene expression by glycolytic and gluconeogenic enzymes – Xueli Bian, Hongfei Jiang, Ying Meng, Ying-ping Li, Jing Fang, Zhimin Lu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00036- Transsulfuration, minor player or crucial for cysteine homeostasis in cancer – Hai-Feng Zhang, Ramon I. Klein Geltink, Seth J. Parker, Poul H. Sorensen. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00036-8 Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia – Benzheng Jiao, Shanshan Liu, Hongguang Zhao, Yuying Zhuang, Shumei Ma, Chenghe Lin, Jifan Hu and Xiaodong Liu. https://www.nature.com/articles/s41419-022-05114-y

Comments/other


The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation – Hyllana C.D. Medeiros, Sophia Y. Lunt. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00757-2 PYGBacking on glycogen metabolism to fuel early memory T cell recall responses – Joseph Longo, McLane J. Watson, Matthew J. Vos, Kelsey S. Williams, Russell G. Jones. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00712-2 SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate – Jessica C. Koe, Keeley G. Hewton, Seth J. Parker. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00763-8 Leucine Dieting Inhibits Immunosuppressive B Cells in Colorectal Cancer. https://aacrjournals.org/cancerdiscovery/article-abstract/12/8/OF15/707242 NUFIP1+ stroma keeps PDAC fed – Holly Sandborg and Mara H. Sherman. https://www.nature.com/articles/s43018-022-00421-x Conference: EACR “Cancer Metabolism“. Bilbao, Spain : 11 – 13 October 2022. Organizers: Arkaitz Carracedo, Christian Frezza, Sarah-Maria Fendt, Sara Zanivan. https://www.eacr.org/conference/cancermetabolism2022/scientific-programme Conference: “Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer“. Oct. 24/25th. Organizers: Payam Gammage, Stephen Tait , Tom MacVicar. Glasgow, UK. https://www.beatson.gla.ac.uk/Beatson-Workshop-October-2022/programme.html

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