Lipid and acetate metabolism
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity – Marta Barradas, Adrián Plaza, Gonzalo Colmenarejo, Iolanda Lázaro, Luis Filipe Costa-Machado, Roberto Martín-Hernández, Victor Micó, José Luis López-Aceituno, Jesús Herranz, Cristina Pantoja, Hector Tejero, Alberto Diaz-Ruiz, Fatima Al-Shahrour, Lidia Daimiel, Viviana Loria-Kohen, Ana Ramirez de Molina, Alejo Efeyan, Manuel Serrano, Oscar J. Pozo, Aleix Sala-Vila and Pablo J. Fernandez-Marcos. https://www.nature.com/articles/s41467-022-33352-3
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells – Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia. https://elifesciences.org/articles/75908
KIF11 manipulates SREBP2‐dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma – Xiang Gu, Qunshan Zhu, Guangyu Tian, Wenbo Song, Tao Wang, Ali Wang, Xiaojun Chen, Songbing Qin. https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.4683
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer – Xiaopeng Xiong, Sumati Hasani, Lyndsay E. A. Young, Dylan R. Rivas, Ashley T. Skaggs, Rebecca Martinez, Chi Wang, Heidi L. Weiss, Matthew S. Gentry, Ramon C. Sun and Tianyan Gao. https://www.nature.com/articles/s41418-022-00974-5
Nucleotides
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma – Sharmistha Pal, Jakub P. Kaplan, Huy Nguyen, Sylwia A. Stopka, Milan R. Savani, Michael S. Regan, Quang-De Nguyen, Kristen L. Jones, Lisa A. Moreau, Jingyu Peng, Marina G. Dipiazza, Andrew J. Perciaccante, Xiaoting Zhu, Bradley R. Hunsel, Kevin X. Liu, Sanda Alexandrescu, Rachid Drissi, Mariella G. Filbin, Samuel K. McBrayer, Nathalie Y.R. Agar, Dipanjan Chowdhury, Daphne A. Haas-Kogan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00325-7
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer – Abhinav Achreja, Tao Yu, Anjali Mittal, Srinadh Choppara, Olamide Animasahun, Minal Nenwani, Fulei Wuchu, Noah Meurs, Aradhana Mohan, Jin Heon Jeon, Itisam Sarangi, Anusha Jayaraman, Sarah Owen, Reva Kulkarni, Michele Cusato, Frank Weinberg, Hye Kyong Kweon, Chitra Subramanian, Max S. Wicha, Sofia D. Merajver, Sunitha Nagrath, Kathleen R. Cho, Analisa DiFeo, Xiongbin Lu and Deepak Nagrath. https://www.nature.com/articles/s42255-022-00636-
IDH
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function – Giulia Notarangelo, Jessica B. Spinelli, Elizabeth M. Perez, Gregory J. Baker, Kiran Kurmi, Ilaria Elia, Sylwia A. Stopka, Gerard Baquer, Jia-Ren Lin, Alexandra J. Golby, Shakchhi Joshi, Heide F. Baron, Jefte M. Drijvers, Peter Georgiev, Alison E. Ringel, Elma Zaganjor, Samuel K. McBrayer, Peter K. Sorger, Arlene H. Sharpe, Kai W. Wucherpfennig, Sandro Santagata, Nathalie Y. R. Agar, Mario L. Suvà, Marcia C. Haigis. https://www.science.org/doi/abs/10.1126/science.abj5104
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma – Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, Joyce H. Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy B. Cameron, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin Jr., Samuel K. McBrayer. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00324-5
Cancer Immunometabolism
Carbon source availability drives nutrient utilization in CD8+ T cells – Irem Kaymak, Katarzyna M. Luda, Lauren R. Duimstra, Eric H. Ma, Joseph Longo, Michael S. Dahabieh, Brandon Faubert, Brandon M. Oswald, McLane J. Watson, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Shelby E. Compton, Zhen Fu, Ralph J. DeBerardinis, Kelsey S. Williams, Ryan D. Sheldon, Russell G. Jones. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00311-4
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity – Qiang Feng, Zhida Liu, Xuexin Yu, Tongyi Huang, Jiahui Chen, Jian Wang, Jonathan Wilhelm, Suxin Li, Jiwon Song, Wei Li, Zhichen Sun, Baran D. Sumer, Bo Li, Yang-Xin Fu and Jinming Gao. https://www.nature.com/articles/s41467-022-32521-8
CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis – Ping Yang, Hong Qin, Yiyu Li, Anhua Xiao, Enze Zheng, Han Zeng, Chunxiao Su, Xiaoqing Luo, Qiannan Lu, Meng Liao, Lei Zhao, Li Wei, Zac Varghese, John F. Moorhead, Yaxi Chen and Xiong Z. Ruan. https://www.nature.com/articles/s41467-022-33349-y
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer – Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song and Wenting Liao. https://www.nature.com/articles/s41467-022-33285-x
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα – Dong Guo, Yingying Tong, Xiaoming Jiang, Ying Meng, Hongfei Jiang, Linyong Du, Qingang Wu, Shan Li, Shudi Luo, Min Li, Liwei Xiao, Haiyan He, Xuxiao He, Qiujing Yu, Jing Fang, Zhimin Lu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00345-X
Mitochondria
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway – Peng Wei, Alex J. Bott, Ahmad A. Cluntun, Jeffrey T. Morgan, Corey N. Cunningham, John C. Schell, Yeyun Ouyang, Scott B. Ficarro, Jarrod A. Marto, Nika N. Danial, Ralph J. DeBerardinis, Jared Rutter. https://www.science.org/doi/full/10.1126/sciadv.abq0117
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions – Pu Zhang, Lindsey T. Brinton, Mehdi Gharghabi, Steven Sher, Katie Williams, Matthew Cannon, Janek S. Walker, Daniel Canfield, Larry Beaver, Casey B. Cempre, Hannah Phillips, Xuyong Chen, Pearlly Yan, Amy Lehman, Peggy Scherle, Min Wang, Kris Vaddi, Robert Baiocchi, Ruoning Wang, Deepa Sampath, Lapo Alinari, James S. Blachly, Rosa Lapalombella. https://www.science.org/doi/full/10.1126/sciadv.abp9005?et_rid=33946976
Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells – James T. Hagen, McLane M. Montgomery, Ericka M. Biagioni, Polina Krassovskaia, Filip Jevtovic, Daniel Shookster, Uma Sharma, Kang Tung, Nickolas T. Broskey, Linda May, Hu Huang, Jeffrey J. Brault, P. Darrell Neufer, Myles C. Cabot, Kelsey H. Fisher-Wellman. https://www.sciencedirect.com/science/article/abs/pii/S0005272822003851
Starvation
Sensitisation of cancer cells to radiotherapy by serine and glycine starvation – Mattia Falcone, Alejandro Huerta Uribe, Vasileios Papalazarou, Alice C. Newman, Dimitris Athineos, Katrina Stevenson, Charles-Etienne Gabriel Sauvé, Yajing Gao, Jin K. Kim, Michael Del Latto, Maria Kierstead, Chao Wu, J. Joshua Smith, Paul B. Romesser, Anthony J. Chalmers, Karen Blyth and Oliver D. K. Maddocks. https://www.nature.com/articles/s41416-022-01965-6
Mitochondrial and metabolic remodelling in human skin fibroblasts in response to glucose availability – Sónia A. Pinho, Cláudio F. Costa, Cláudia M. Deus, Sonia L. C. Pinho, Inês Miranda-Santos, Gonçalo Afonso, Olivia Bagshaw, Jeffrey A. Stuart, Paulo J. Oliveira, Teresa Cunha-Oliveira. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16413
cAMP-Protein Kinase A and Stress-Activated MAP Kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation – Armando Jesús Pérez-Díaz, Beatriz Vázquez-Marín, Jero Vicente-Soler, Francisco Prieto-Ruiz, Teresa Soto, Alejandro Franco, José Cansado and Marisa Madrid. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2125204
AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation [In collection: Metabolism] – Kuan-Jung Chen, Jia-Wei Hsu, Fang-Jen S. Lee. https://journals.biologists.com/jcs/article/135/18/jcs259609/276628
mTOR
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids – Peter Gollwitzer, Nina Grützmacher, Sabine Wilhelm, Daniel Kümmel and Constantinos Demetriades. https://www.nature.com/articles/s41556-022-00976-y
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition – Gianluca Figlia, Sandra Müller, Anna M. Hagenston, Susanne Kleber, Mykola Roiuk, Jan-Philipp Quast, Nora ten Bosch, Damian Carvajal Ibañez, Daniela Mauceri, Ana Martin-Villalba and Aurelio A. Teleman. https://www.nature.com/articles/s41556-022-00977-x
Brain-restricted mTOR inhibition with binary pharmacology – Ziyang Zhang, Qiwen Fan, Xujun Luo, Kevin Lou, William A. Weiss and Kevan M. Shokat. https://www.nature.com/articles/s41586-022-05213-y
Invading Bacterial Pathogens Activate Transcription Factor EB in Epithelial Cells through the Amino Acid Starvation Pathway of mTORC1 Inhibition – Liliane Cabral-Fernandes, Shawn Goyal, Armin Farahvash, Jessica Tsalikis, Dana J. Philpott, Stephen E. Girardin. https://journals.asm.org/doi/abs/10.1128/mcb.00241-22
Tissue-restricted inhibition of mTOR using chemical genetics – Douglas R. Wassarman, Kondalarao Bankapalli, Leo J. Pallanck, and Kevan M. Shokat. https://www.pnas.org/doi/10.1073/pnas.2204083119
Glucose-driven TOR–FIE–PRC2 signalling controls plant development – Ruiqiang Ye, Meiyue Wang, Hao Du, Shweta Chhajed, Jin Koh, Kun-hsiang Liu, Jinwoo Shin, Yue Wu, Lin Shi, Lin Xu, Sixue Chen, Yijing Zhang and Jen Sheen. https://www.nature.com/articles/s41586-022-05171-5
Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma – Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas and Ryan M. Young. https://www.nature.com/articles/s41467-022-33142-x
Hypoxia
FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A – Xiaohai Wang, Lourdes Brea, Xiaodong Lu, Galina Gritsina, Su H. Park, Wanqing Xie, Jonathan C. Zhao and Jindan Yu. https://www.nature.com/articles/s41388-022-02423-6
Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation – Chloe-Anne Martinez, Yannasittha Jiramongkol, Neha Bal, Imala Alwis, Polina E. Nedoboy, Melissa MJ. Farnham, Mark D. White, Peter A. Cistulli, Kristina M. Cook. https://www.jbc.org/article/S0021-9258(22)00979-6
Reviews
Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer – Jacob M. Winter, Tarun Yadav, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00708-0
Glutaminase Inhibitors—Do They Have a Role in the Treatment of Metastatic Clear-Cell Renal Cell Carcinoma? – Janet E. Brown. https://jamanetwork.com/journals/jamaoncology/article-abstract/2795983
Metabolic reprogramming: a bridge between aging and tumorigenesis – Stanislav Drapela, Didem Ilter, Ana P. Gomes. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13261
Genetic approaches to understand cellular responses to oxygen availability – Brian M. Ortmann, James A. Nathan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16072
Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis – Valeria Manuelli, Chiara Pecorari, Giuseppe Filomeni, Ester Zito. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16110
Metabolic Reprogramming in Hematologic Malignancies: Advances and Clinical Perspectives – Zhuoya Yu, Xiangxiang Zhou, Xin Wang. https://aacrjournals.org/cancerres/article/82/17/2955/708282
The Central Role of mTORC1 in Amino Acid Sensing – Shusheng Yue, Guanya Li, Shanping He, Tingting Li. https://aacrjournals.org/cancerres/article-abstract/82/17/2964/708284
AMPK: An odyssey of a metabolic regulator, a tumor suppressor, and now a contextual oncogene – Vasudevarao Penugurti, Yasaswi Gayatri Mishra, Bramanandam Manavathi. https://www.sciencedirect.com/science/article/abs/pii/S0304419X2200110X
Comments
Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer – Vaibhav Jain, Ravi K. Amaravadi. https://aacrjournals.org/cancerdiscovery/article-abstract/12/9/2023/708772
Plasma L-Arginine Predicts Clinical Response to Immune Checkpoint Inhibitors – https://aacrjournals.org/cancerdiscovery/article-abstract/12/9/OF6/708788
Metabolite-driven antitumor immunity [D-2HG] – https://www.science.org/doi/10.1126/science.ade3697
Glucose metabolism
Glycolytic oscillations in HeLa cervical cancer cell spheroids – Takashi Amemiya, Kenichi Shibata, Junpei Takahashi, Masatoshi Watanabe, Satoshi Nakata, Kazuyuki Nakamura, Tomohiko Yamaguchi. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16454
ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3 – Mengnan Hu, Ruoxuan Bao, Miao Lin, Xiao-Ran Han, Ying-Jie Ai, Yun Gao, Kun-Liang Guan, Yue Xiong and Hai-Xin Yuan. https://www.nature.com/articles/s41388-022-02453-0
PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma – Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnölzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt and Violaine Goidts. https://www.nature.com/articles/s41389-022-00433-3
Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression – Ya Jiang, Ting Wang, Dandan Sheng, Chaoqiang Han, Tian Xu, Peng Zhang, Weiyi You, Weiwei Fan, Zhiyong Zhang, Tengchuan Jin, Xiaotao Duan, Xiao Yuan, Xing Liu, Kaiguang Zhang, Ke Ruan, Jue Shi, Jing Guo, Aoxing Cheng, Zhenye Yang. https://www.jbc.org/article/S0021-9258(22)01005-5/fulltext
Amino acid metabolism
GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma – Sawako Suzuki, Divya Venkatesh, Hiroaki Kanda, Akitoshi Nakayama, Hiroyuki Hosokawa, Eunyoung Lee, Takashi Miki, Brent R. Stockwell, Koutaro Yokote, Tomoaki Tanaka, Carol Prives. https://aacrjournals.org/cancerres/article-abstract/82/18/3209/709027
GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors – Yunzheng Li, Binghua Li, Yanchao Xu, Liyuan Qian, Tiancheng Xu, Gang Meng, Huan Li, Ye Wang, Laizhu Zhang, Xiang Jiang, Qi Liu, Yuanyuan Xie, Chunxiao Cheng, Beicheng Sun, Decai Yu. https://aacrjournals.org/cancerres/article-abstract/82/18/3223/709031
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling – Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson and Ze’ev A. Ronai. https://www.nature.com/articles/s41556-022-00985-x
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis – Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Robero Pili Is a corresponding author, Ronald C Wek Is a corresponding author, Kirk A Staschke. https://elifesciences.org/articles/81083
Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma. The CANTATA Randomized Clinical Trial – Nizar M. Tannir, Neeraj Agarwal, Camillo Porta, Nicola J. Lawrence, Robert Motzer, Bradley McGregor, Richard J. Lee, Rohit K. Jain, Nancy Davis, Leonard J. Appleman, Oscar Goodman Jr, Walter M. Stadler, Sunil Gandhi, Daniel M. Geynisman, Roberto Iacovelli, Begoña Mellado, Juan Manuel Sepúlveda Sánchez, Robert Figlin, Thomas Powles, Lalith Akella, Keith Orford, Bernard Escudier. https://jamanetwork.com/journals/jamaoncology/article-abstract/2795979
Metabolism and Cancer articles 