Amino acids and one-carbon
Metabolic regulation by p53 prevents R-loop-associated genomic instability – Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01429-2
BCAT1 redox function maintains mitotic fidelity – Liliana Francois, Pavle Boskovic, Julian Knerr, Wei He, Gianluca Sigismondo, Carsten Schwan, Tushar H. More, Magdalena Schlotter, Jeroen Krijgsveld, Karsten Hiller, Robert Grosse, Peter Lichter, Bernhard Radlwimmer. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01379-1
Asparagine bioavailability regulates the translation of MYC oncogene – Sankalp Srivastava, Jie Jiang, Jagannath Misra, Gretchen Seim, Kirk A. Staschke, Minghua Zhong, Leonardo Zhou, Yu Liu, Chong Chen, Utpal Davé, Reuben Kapur, Sandeep Batra, Chi Zhang, Jiehao Zhou, Jing Fan, Ronald C. Wek and Ji Zhang. https://www.nature.com/articles/s41388-022-02474-9
Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins – Catarina Pechincha, Sven Groessl, Robert Kalis, Melanie de Almeida, Andrea Zanotti, Marten Wittmann, Martin Schneider, Rafael P. de Campos, Sarah Rieser, Marlene Brandstetter, Alexander Schleiffer, Karin Müller-Decker, Dominic Helm, Sabrina Jabs, David Haselbach, Marius K. Lemberg, Johannes Zuber, Wilhelm Palm. https://www.science.org/doi/10.1126/science.abn5637
Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1 – Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Q. Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong. https://www.jci.org/articles/view/161408
Starvation / mTOR / UPR-ISR
An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs – Cornelius Schneider, Florian Erhard, Beyenech Binotti, Alexander Buchberger, Jörg Vogel, Utz Fischer. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01317-1
A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling – Johanna B. Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan E. Eickhoff, Peter J. Murray. https://www.jbc.org/article/S0021-9258(22)01072-9/fulltext
Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells – Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas and Carmen Palacios. https://www.nature.com/articles/s41419-022-05346-y
Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer – Woo Kyung Lee Doolittle, Sunmi Park, Seul Gi Lee, Seonhyang Jeong, Gibbeum Lee, Dongryeol Ryu, Kristina Schoonjans, Johan Auwerx, Jandee Lee and Young Suk Jo. https://www.nature.com/articles/s41388-022-02484-7
Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention – Laura Matabishi-Bibi, Drice Challal, Mara Barucco, Domenico Libri and Anna Babour. https://www.nature.com/articles/s41467-022-34133-8
Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner – Iris Divé, Kevin Klann, Jonas B. Michaelis, Dennis Heinzen, Joachim P. Steinbach, Christian Münch and Michael W. Ronellenfitsch. https://www.nature.com/articles/s41420-022-01195-y
Glucose metabolism
ATF4-dependent fructolysis fuels growth of glioblastoma multiforme – Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You and Xinjian Li. https://www.nature.com/articles/s41467-022-33859-9
The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans – Mehul Vora, Stephanie M. Pyonteck, Tatiana Popovitchenko, Tarmie L. Matlack, Aparna Prashar, Nanci S. Kane, John Favate, Premal Shah and Christopher Rongo. https://www.nature.com/articles/s41467-022-33849-x
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma – Qi-tao Chen, Zhi-yuan Zhang, Qiao-ling Huang, Hang-zi Chen, Wen-bin Hong, Tianwei Lin, Wen-xiu Zhao, Xiao-min Wang, Cui-yu Ju, Liu-zheng Wu, Ya-ying Huang, Pei-pei Hou, Wei-jia Wang, Dawang Zhou, Xianming Deng and Qiao Wu. https://www.nature.com/articles/s42255-022-00642-5
Glucose-6-phosphate dehydrogenase exerts anti-stress effects independently of its enzymatic activity – Xiaohan Jin, Xuexue Li, Lifang Li, Benfu Zhong, Yang Hong, Jing Niu, Binghui Li. https://www.jbc.org/article/S0021-9258(22)01030-4/fulltext
Anti‐tumour effects of a macrolide analog F806 in oesophageal squamous cell carcinoma cells by targeting and promoting GLUT1 autolysosomal degradation – Xiang Li, Liyan Li, Xiaodong Wu, Bing Wen, Wan Lin, Yufei Cao, Lei Xie, Hefeng Zhang, Geng Dong, Enmin Li, Liyan Xu, Yinwei Cheng. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16545
Structural mechanism of SGLT1 inhibitors – Yange Niu, Wenhao Cui, Rui Liu, Sanshan Wang, Han Ke, Xiaoguang Lei and Lei Chen. https://www.nature.com/articles/s41467-022-33421-7
Glucose deprivation and sensing
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK – Chen-Song Zhang, Mengqi Li, Yu Wang, Xiaoyang Li, Yue Zong, Shating Long, Mingliang Zhang, Jin-Wei Feng, Xiaoyan Wei, Yan-Hui Liu, Baoding Zhang, Jianfeng Wu, Cixiong Zhang, Wenhua Lian, Teng Ma, Xiao Tian, Qi Qu, Yaxin Yu, Jinye Xiong, Dong-Tai Liu, Zhenhua Wu, Mingxia Zhu, Changchuan Xie, Yaying Wu, Zheni Xu, Chunyan Yang, Junjie Chen, Guohong Huang, Qingxia He, Xi Huang, Lei Zhang, Xiufeng Sun, Qingfeng Liu, Abdul Ghafoor, Fu Gui, Kaili Zheng, Wen Wang, Zhi-Chao Wang, Yong Yu, Qingliang Zhao, Shu-Yong Lin, Zhi-Xin Wang, Hai-Long Piao, Xianming Deng and Sheng-Cai Lin. https://www.nature.com/articles/s42255-022-00640-7
Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation – Yang S Chen, Wanfu Hou, Sharon Tracy, Alex T Harvey, Vince Harjono, Fan Xu, James J Moresco, John R Yates III, Brian M Zid. https://elifesciences.org/articles/76965
TSC22D4 interacts with Akt1 to regulate glucose metabolism – Sevgican Demir, Gretchen Wolff, Annika Wieder, Adriano Maida, Lea Bühler, Maik Brune, Oksana Hautzinger, Annette Feuchtinger, Tanja Poth, Julia Szendroedi, Stephan Herzig, Bilgen Ekim Üstünel. https://www.science.org/doi/full/10.1126/sciadv.abo5555
Lipid metabolism
Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner – Damian E. Berardi, Althea Bock-Hughes, Alexander R. Terry, Lauren E. Drake, Grazyna Bozek, Kay F. Macleod. https://www.science.org/doi/full/10.1126/sciadv.abo2510
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma – Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon and Amato J. Giaccia. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00290-z
Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells – Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A Frias, David A Foster. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276579
Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids – Guangyuan Zhao, Yuying Tan, Horacio Cardenas, David Vayngart, Yinu Wang, Hao Huang, Russell Keathley, Jian-Jun Wei, Christina R. Ferreira, Sandra Orsulic, Ji-Xin Cheng and Daniela Matei. https://www.pnas.org/doi/10.1073/pnas.2203480119
Cancer Immunometabolism
A Cancer Cell–Intrinsic GOT2–PPARδ Axis Suppresses Antitumor Immunity – Jaime Abrego, Hannah Sanford-Crane, Chet Oon, Xu Xiao, Courtney B. Bett, Duanchen Sun, Shanthi Nagarajan, Luis Diaz, Holly Sandborg, Sohinee Bhattacharyya, Zheng Xia, Lisa M. Coussens, Peter Tontonoz, Mara H. Sherman. https://aacrjournals.org/cancerdiscovery/article/12/10/2414/709426
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice – Muna Al-Habsi, Kenji Chamoto, Ken Matsumoto, Norimichi Nomura, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Aprilia Maharani, Yuka Nakajima, Yibo Wu, Yayoi Nomura, Rosemary Menzies, Masaki Tajima, Koji Kitaoka, Yasuharu Haku, Sara Delghandi, Keiko Yurimoto, Fumihiko Matsuda, So Iwata, Toshihiko Ogura, Sidonia Fagarasan, Tasuku Honjo. https://www.science.org/doi/abs/10.1126/science.abj3510
NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function – Ajay Kumar, Emily L. Yarosz, Anthony Andren, Li Zhang, Costas A. Lyssiotis, Cheong-Hee Chang. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01366-3
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment – Spencer R. Rosario, Randall J. Smith Jr, Santosh K. Patnaik, Song Liu, Joseph Barbi and Sai Yendamuri. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00292-x
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance – Qingzhu Shi, Qicong Shen, Yanfang Liu, Yang Shi, Wenwen Huang, Xi Wang, Zhiqing Li, Yangyang Chai, Hao Wang, Xiangjia Hu, Nan Li, Qian Zhang, Xuetao Cao. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00376-2
Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion – Zenan Wang, Binghao Li, Shan Li, Wenlong Lin, Zhan Wang, Shengdong Wang, Weida Chen, Wei Shi, Tao Chen, Hao Zhou, Eloy Yinwang, Wenkan Zhang, Haochen Mou, Xupeng Chai, Jiahao Zhang, Zhimin Lu and Zhaoming Ye. https://www.nature.com/articles/s41467-022-34064-4
Mitochondria / nucleotides
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch – Erika Fernández-Vizarra, Sandra López-Calcerrada, Ana Sierra-Magro, Rafael Pérez-Pérez, Luke E. Formosa, Daniella H. Hock, María Illescas, Ana Peñas, Michele Brischigliaro,Shujing Ding, Ian M. Fearnley, Charalampos Tzoulis, Robert D.S. Pitceathly, Joaquín Arenas, Miguel A. Martín, David A. Stroud, Massimo Zeviani, Michael T. Ryan, Cristina Ugalde. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00395-3
HIRA loss transforms FH-deficient cells – Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R. Maher, Grant D. Stewart, Sakari Vanharanta, David J. Adams, Christian Frezza. https://www.science.org/doi/full/10.1126/sciadv.abq8297
Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation – Hae J Park, Mark A Gregory, Vadym Zaberezhnyy, Andrew Goodspeed, Craig T Jordan, Jeffrey S Kieft, James DeGregori. https://elifesciences.org/articles/79940
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation – Kenji Miki, Mikako Yagi, Koji Yoshimoto, Dongchon Kang and Takeshi Uchiumi. https://www.nature.com/articles/s41389-022-00437-z
Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy [methotrexate] – Ahram Jang, Boryana Petrova, Taek-Chin Cheong, Miriam E. Zawadzki, Jill K. Jones, Andrew J. Culhane, Frederick B. Shipley, Roberto Chiarle, Eric T. Wong, Naama Kanarek, Maria K. Lehtinen. https://www.cell.com/neuron/fulltext/S0896-6273(22)00741-3
Miscellaneous
Scaffold-mediated switching of lymphoma metabolism in culture – Rachana Bhatt, Dashnamoorthy Ravi, Andrew M. Evens and Biju Parekkadan. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00291-y
Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition – Samuel Ogden, Kashmala Carys, Ibrahim Ahmed, Jason Bruce and Andrew D. Sharrocks. https://www.nature.com/articles/s41388-022-02465-w
Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls – Julian O. Kim, Robert Balshaw, Connel Trevena, Shantanu Banerji, Leigh Murphy, David Dawe, Lawrence Tan, Sadeesh Srinathan, Gordon Buduhan, Biniam Kidane, Gefei Qing, Michael Domaratzki and Michel Aliani. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00294-9
Reviews
The role of lipids in cancer progression and metastasis – Miguel Martin-Perez, Uxue Urdiroz-Urricelqui, Claudia Bigas, Salvador Aznar Benitah. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00447-8
Amino acid metabolism in primary bone sarcomas – Jennifer A. Jiménez, Elizabeth R. Lawlor and Costas A. Lyssiotis. https://www.frontiersin.org/articles/10.3389/fonc.2022.1001318/full
Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers – Deborah Y. Moss, Christopher McCann, Emma M. Kerr. https://www.science.org/doi/abs/10.1126/scisignal.abj3490
GOT2 consider the tumor microenvironment – Brian T. Do, Matthew G. Vander Heiden. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00195-9
Targeting PDAC metabolism: Environment determines what has GOT2 give – Oliver J. Newsom, Lucas B. Sullivan
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00451-X
Nutrient availability as an arbiter of cell size – Douglas R. Kellogg, Petra Anne Levin. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00147-7
Non-canonical mTORC1 signaling at the lysosome – Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00117-9
Principles and functions of metabolic compartmentalization – Liron Bar-Peled and Nora Kory. https://www.nature.com/articles/s42255-022-00645-2
Metabolic guidance and stress in tumors modulate antigen-presenting cells – Jaeoh Park, Limei Wang and Ping-Chih Ho. https://www.nature.com/articles/s41389-022-00438-y
Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer – Léa Montégut, Rafael de Cabo, Laurence Zitvogel, Guido Kroemer. https://aacrjournals.org/cancerdiscovery/article-abstract/12/10/2258/709430
Comments
Nuclear TCA cycle reactions – Melina Casadio. https://www.nature.com/articles/s41556-022-01006-7
Starving cancer into submission by activating BAT – Mohammed K. Hankir, Annett Hoffmann, Florian Seyfried. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00399-0
Gliomas lean on pyrimidines – Joseph Willson. https://www.nature.com/articles/s41568-022-00515-9
Liver cancer metabolism: a hexokinase from the stars – Aveline Filliol and Robert F. Schwabe. https://www.nature.com/articles/s42255-022-00659-w
Glutamine, MTOR and autophagy: a multiconnection relationship – Clément Bodineau, Mercedes Tomé, Piedad del Socorro Murdoch and Raúl V. Durán. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2062875
Cold exposure as anti-cancer therapy – Mariia Yuneva. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00437-8
Transient Systemic Autophagy Ablation Irreversibly Inhibits Lung Tumor Cell Metabolism and Promotes T-Cell Mediated Tumor Killing – Kyle Nunn and Jessie Yanxiang Guo. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2141534
Metabolism and Cancer articles 