MetaboList – December 2022


Amino acid metabolism


Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression – Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez and Christian Frezza. https://www.nature.com/articles/s41467-022-35036-4

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma – Akash K. Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T. Tcheuyap, Faeze Saatchi, Quyen N. Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D. Rao, Brandon Faubert, Panayotis Pachnis, Lauren G. Zacharias, Hieu Vu, Feng Cai, Thomas P. Mathews, Giannicola Genovese, Barbara S. Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis. https://www.science.org/doi/full/10.1126/sciadv.abp8293

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia – Hengyou Weng, Feng Huang, Zhaojin Yu, Zhenhua Chen, Emily Prince, Yalin Kang, Keren Zhou, Wei Li, Jiacheng Hu, Chen Fu, Tursunjan Aziz, Hongzhi Li, Jingwen Li, Ying Yang, Li Han, Subo Zhang, Yuelong Ma, Mingli Sun, Huizhe Wu, Zheng Zhang, Mark Wunderlich, Sean Robinson, Daniel Braas, Johanna ten Hoeve, Bin Zhang, Guido Marcucci, James C. Mulloy, Keda Zhou, Hong-Fang Tao, Xiaolan Deng, David Horne, Minjie Wei, Huilin Huang, Jianjun Chen. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00495-0

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1 – Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Q. Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao and Wei-Xing Zong. https://www.jci.org/articles/view/161408

Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2 – Wen Chen, Liang Wen, Yingying Bao, Zengwei Tang, Jianhui Zhao, Xiaozhen Zhang, Tao Wei, Jian Zhang, Tao Ma, Qi Zhang, Xiao Zhi, Jin Li, Cheng Zhang, Lei Ni, Muchun Li and Tingbo Liang. https://www.pnas.org/doi/10.1073/pnas.2203894119


Lipid/Acetyl CoA metabolism


mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species – Aaron M. Hosios, Meghan E. Wilkinson, Molly C. McNamara, Krystle C. Kalafut, Margaret E. Torrence, John M. Asara and Brendan D. Manning. https://www.nature.com/articles/s42255-022-00706-6

Acetyl-CoA-mediated autoacetylation of fatty acid synthase as a metabolic switch of de novo lipogenesis in Drosophila – Ting Miao, Jinoh Kim, Ping Kang, Hideji Fujiwara, Fong-Fu Hsu and Hua Bai. https://www.pnas.org/doi/10.1073/pnas.2212220119

Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells – Tomoko Warita, Nanami Irie, Yaxuan Zhou, Jiro Tashiro, Akihiro Sugiura, Zoltán N Oltvai, Katsuhiko Warita.. https://www.sciencedirect.com/science/article/pii/S0024320522009493

Monounsaturated and Diunsaturated Fatty Acids Sensitize Cervical Cancer to Radiation Therapy – Naoshad Muhammad, Fiona Ruiz, Jennifer Stanley, Ramachandran Rashmi, Kevin Cho, Kay Jayachandran, Michael C. Zahner, Yi Huang, Jin Zhang, Stephanie Markovina, Gary J. Patti, Julie K. Schwarz. https://aacrjournals.org/cancerres/article-abstract/82/24/4515/711531


Moonlighting functions of metabolic proteins


Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer – Juan Liu, Cen Zhang, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Ludvinna Bazile, Lanjing Zhang, Bruce G. Haffty, Wenwei Hu and Zhaohui Feng. https://www.nature.com/articles/s42255-022-00708-4

Non‐canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism – Ying Shu, Yijie Hao, Junru Feng, Haiying Liu, Shi-ting Li, Jiaqian Feng, Zetan Jiang, Ling Ye, Yingli Zhou, Yuchen Sun, Zilong Zhou, Haoran Wei, Ping Gao, Huafeng Zhang, Linchong Sun. https://www.embopress.org/doi/abs/10.15252/embj.2022111550

Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation – Flávio P. Veras, Gabriel A. Publio, Bruno M. Melo, Douglas S. Prado, Thainá Norbiato, Nerry T. Cecilio, Carlos Hiroki, Luis Eduardo A. Damasceno, Rebecca Jung, Juliana E. Toller-Kawahisa, Timna V. Martins, Stella F. Assunção, Diogenes Lima, Marcia G. Alves, Gabriel V. Vieira, Lucas A. Tavares, Ana L.R. Alves-Rezende, Susanne H. Karbach, Helder I. Nakaya, Thiago M. Cunha, Cacilda S. Souza, Fernando Q. Cunha, Katiuchia U. Sales, Ari Waisman, José C. Alves-Filho. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01796-X

Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence – Tao Dai, Spencer R. Rosario, Eriko Katsuta, Abhisha Sawant Dessai, Emily J. Paterson, Aaron T. Novickis, Eduardo Cortes Gomez, Bokai Zhu, Song Liu, Hai Wang, Scott I. Abrams, Mukund Seshadri, Wiam Bshara, Subhamoy Dasgupta. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01639-4


Glucose/lactate/nucleotide metabolism


Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis – Joris Guyon, Ignacio Fernandez-Moncada, Claire M Larrieu, Cyrielle L Bouchez, Antonio C Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M Ravi, Heidi Espedal, Gro Vatne Røsland, Boutaina Daher, Aurélien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero-Garmendia, Barbara Klink, Konrad Grützmann, Marie-Alix Derieppe, Thibaut Molinié, Nina Obad, Céline Léon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon. https://www.embopress.org/doi/full/10.15252/emmm.202115343

Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism – Yan Ding, Sujie Gao, Jiabin Zheng and Xuebo Chen. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00293-w

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma – William D. Gwynne, Yujin Suk, Stefan Custers, Nicholas Mikolajewicz, Jeremy K. Chan, Zsolt Zador, Shawn C. Chafe, Kui Zhai, Laura Escudero, Cunjie Zhang, Olga Zaslaver, Chirayu Chokshi, Muhammad Vaseem Shaikh, David Bakhshinyan, Ian Burns, Iqra Chaudhry, Omri Nachmani, Daniel Mobilio, William T. Maich, Patricia Mero, Kevin R. Brown, Andrew T. Quaile, Chitra Venugopal, Jason Moffat, J. Rafael Montenegro-Burke, Sheila K. Singh. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00500-1


Mitochondria / Hypoxia


Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function – Wonyul Jang, Dmytro Puchkov, Paula Samsó, YongTian Liang, Michal Nadler-Holly, Stephan J. Sigrist, Ulrich Kintscher, Fan Liu, Kamel Mamchaoui, Vincent Mouly, Volker Haucke. https://www.science.org/doi/abs/10.1126/science.abq5209

Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia – Angeliki Karagiota, Amalia Kanoura, Efrosyni Paraskeva, George Simos, Georgia Chachami. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16694

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase (PDH) phosphorylation – Takeshi Ikizawa, Kazutaka Ikeda, Makoto Arita, Shojiro Kitajima, Tomoyoshi Soga, Hidenori Ichijo, Isao Naguro. https://www.jbc.org/article/S0021-9258(22)01280-7

A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer – Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke, Neesha Dhani, David D’Souza, Ting-Yim Lee, Naz Chaudary, Jeffrey Bruce, Melania Pintilie, Rob Cairns, Douglass Vines, Sara Pakbaz, David Jaffray, Ur Metser, Marjan Rouzbahman, Michael Milosevic, Marianne Koritzinsky. https://aacrjournals.org/clincancerres/article-abstract/28/24/5263/711455

Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells – Kshitiz, Junaid Afzal. Yasir Suhail, Hao Chang, Maimon E. Hubbi, Archer Hamidzadeh, Ruchi Goyal, Yamin Liu, Peng Sun, Stefania Nicoli, Chi V. Dang, Andre Levchenko. https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00462-8

Exploratory meta-analysis of hypoxic transcriptomes using a precise transcript reference sequence set – Yoko Ono and Hidemasa Bono. https://www.life-science-alliance.org/content/6/1/e202201518.abstract


Starvation / AMPK


Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha – Qi Zhou, Bingbing Hao, Xiaolei Cao, Lin Gao, Zhenyue Yu, Yang Zhao, Mingrui Zhu, Guoxuan Zhong, Fangtao Chi, Xiaoming Dai, Jizhong Mao, Yibing Zhu, Ping Rong, Liang Chen, Xueli Bai, Cunqi Ye, Shuai Chen, Tingbo Liang, Li Li, Xin-Hua Feng, Minjia Tan, Bin Zhao. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01058-9

A Subset of VEGFR-TKIs Activates AMPK in LKB1-mutant Lung Cancer – Lujie Yang, Qin Zhang, Yanli Xiong, Zhaoqian Dang, He Xiao, Qian Chen, Xiaoyan Dai, Lei Zhang, Jianwu Zhu, Dong Wang, Mengxia Li. https://onlinelibrary.wiley.com/doi/10.1111/cas.15677

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis – Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J. Ovens, Gavin Tjin, Luke M. McAloon, Dingyi Yu, Naomi X.Y. Ling, Matthew J. Sanders, Jonathan S. Oakhill, John W. Scott, Gregory R. Steinberg, Kim Loh, Bruce E. Kemp, Kei Sakamoto, Sandra Galic. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01758-2

Mitochondrial genome recovery by ATFS-1 is essential for development after starvation – Nandhitha Uma Naresh, Sookyung Kim, Tomer Shpilka, Qiyuan Yang, Yunguang Du, Cole M. Haynes. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01771-5

4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer – Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Jiangbo Jin, Yufeng Liu, Mingxi Gan, Yi Yuan, Longhua Sun, Xiaolei Li, Tianyu Han and Jian-Bin Wang. https://www.nature.com/articles/s41419-022-05466-5


mTOR


Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells – Arlet Hernandez, Manoj Sonavane, Kelly R Smith, Jensyn Seiger, Marie E Migaud, Natalie R Gassman. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0278516

Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1 – Biljana Blagojevic, Fadi Almouhanna, Gernot Poschet, Stefan Wölfl. https://pubmed.ncbi.nlm.nih.gov/36497120/

Wdr59 promotes or inhibits TORC1 activity depending on cellular context – Yingbiao Zhang, Chun-Yuan Ting, Shu Yang, John Reich, Karenne Fru and Mary A. Lilly. https://www.pnas.org/doi/10.1073/pnas.2212330120

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans – Terytty Yang Li, Arwen W. Gao, Xiaoxu Li, Hao Li, Yasmine J. Liu, Amelia Lalou, Nagammal Neelagandan, Felix Naef, Kristina Schoonjans, Johan Auwerx. https://rupress.org/jcb/article/222/1/e202205045/213623


Cancer Immunometabolism


Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer – Federica Cappellesso, Marie-Pauline Orban, Niranjan Shirgaonkar, Emanuele Berardi, Jens Serneels, Marie-Aline Neveu, Daria Di Molfetta, Francesca Piccapane, Rosa Caroppo, Lucantonio Debellis, Tessa Ostyn, Nicolas Joudiou, Lionel Mignion, Elena Richiardone, Bénédicte F. Jordan, Bernard Gallez, Cyril Corbet, Tania Roskams, Ramanuj DasGupta, Sabine Tejpar, Mario Di Matteo, Daniela Taverna, Stephan J. Reshkin, Baki Topal, Federico Virga and Massimiliano Mazzone. https://www.nature.com/articles/s43018-022-00470-2

Immunoediting instructs tumor metabolic reprogramming to support immune evasion – Chin-Hsien Tsai, Yu-Ming Chuang, Xiaoyun Li, Yi-Ru Yu, Sheue-Fen Tzeng, Shao Thing Teoh, Katherine E. Lindblad, Mario Di Matteo, Wan-Chen Cheng, Pei-Chun Hsueh, Kung-Chi Kao, Hana Imrichova, Likun Duan, Hector Gallart-Ayala, Pei-Wen Hsiao, Massimiliano Mazzone, Julijana Ivanesevic, Xiaojing Liu, Karin E. de Visser, Amaia Lujambio, Sophia Y. Lunt, Susan M. Kaech, Ping-Chih Ho. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00540-X

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein – Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K. Fyfe, Malo Leprohon, Jie Yang, F. Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G. Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra. https://www.science.org/doi/full/10.1126/sciimmunol.ade5686

Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells – Lea Katharina Picard, Elisabeth Littwitz-Salomon, Herbert Waldmann, Carsten Watzl. https://www.mdpi.com/2073-4409/11/21/3489

Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth – Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu, Li Cai, John M. Asara, Marina Pasca di Magliano, Genevieve M. Boland, Keith T. Flaherty, Kenneth D. Swanson, David Liu, Joshua D. Rabinowitz and Bin Zheng. https://www.nature.com/articles/s42255-022-00676-9

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments – Ya-Ting Wang, Alissa J. Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S.A. Perry. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01639-4

Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity – Xinyi Zhang, Alexandra A. Halberstam, Wanling Zhu, Brooks P. Leitner, Durga Thakral, Marcus W. Bosenberg and Rachel J. Perry. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00296-7

Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells – Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho-Ryun Chung, Uta-Maria Bauer, Till Adhikary, Alexander Visekruna. https://www.embopress.org/doi/abs/10.15252/embr.202254685

Increased tumor glycolysis is associated with decreased immune infiltration across human solid tumors – Ivan J Cohen, Fresia Pareja, Nicholas D Socci, Ronglai Shen, Ashley S Doane, Jazmin Schwartz, Raya Khanin, Elizabeth A Morris, Elizabeth J Sutton, Ronald G Blasberg. https://www.frontiersin.org/articles/10.3389/fimmu.2022.880959/full

Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer – Hannah N. Bell, Amanda K. Huber, Rashi Singhal, Navyateja Korimerla, Ryan J. Rebernick, Roshan Kumar, Marwa O. El-derany, Peter Sajjakulnukit, Nupur K. Das, Samuel A. Kerk, Sumeet Solanki, Jadyn G. James, Donghwan Kim, Li Zhang, Brandon Chen, Rohit Mehra, Timothy L. Frankel, Balázs Győrffy, Eric R. Fearon, Marina Pasca di Magliano, Frank J. Gonzalez, Ruma Banerjee, Daniel R. Wahl, Costas A. Lyssiotis, Michael Green, Yatrik M. Shah. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00504-6


Miscellaneous


Coupling-dependent metabolic ultradian rhythms in confluent cells – Shuzhang Yang, Shin Yamazaki, Kimberly H. Cox, Yi-Lin Huang, Evan W. Miller and Joseph S. Takahashi. https://www.pnas.org/doi/abs/10.1073/pnas.2211142119

Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis – Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Siyuan Qin, Hai-Ning Chen, Liyuan Peng, Zhe Zhang, Bowen Li, Maochao Luo, Tingting Zhang, Hui Ming, Ning Ding, Lei Li, Na Xie, Wei Gao, Wei Zhang, Edouard C Nice, Yuquan Wei, Canhua Huang. https://www.embopress.org/doi/full/10.15252/emmm.202216082

Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments – Adam J. Rauckhorst, Nicholas Borcherding, Daniel J. Pape, Alora S. Kraus, Diego A. Scerbo, Eric B. Taylor. https://www.sciencedirect.com/science/article/pii/S221287782200165X

Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer – Hongmiao Wang, Huixun Jia, Yang Gao, Haosong Zhang, Jin Fan, Lijie Zhang, Fandong Ren, Yandong Yin, Yuping Cai, Ji Zhu and Zheng-Jiang Zhu. https://www.nature.com/articles/s41467-022-35511-y

Effects of cancer-associated point mutations on the structure, function, and stability of isocitrate dehydrogenase 2 – Xiang Chen, Peipei Yang, Yue Qiao, Fei Ye, Zhipeng Wang, Mengting Xu, Xiaowang Han, Li Song, Yuehong Wu, Wen-Bin Ou. https://www.nature.com/articles/s41598-022-23659-y

ATM inhibition drives metabolic adaptation via induction of macropinocytosis – Zhentai Huang, Chi-Wei Chen, Raquel Buj, Naveen Kumar Tangudu, Richard S. Fang, Kelly E. Leon, Erika S. Dahl, Erika L. Varner, Eliana von Krusenstiern, Aidan R. Cole, Nathaniel W. Snyder, Katherine M. Aird. https://rupress.org/jcb/article/222/1/e202007026/213697


Reviews


Regulation and function of the mammalian tricarboxylic acid cycle – Paige K. Arnold, Lydia W.S. Finley. https://www.jbc.org/article/S0021-9258(22)01281-9/fulltext

Targeting fatty acid metabolism in glioblastoma – Jason Miska and Navdeep S. Chandel. https://www.jci.org/articles/view/163448

Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives – Nitin Patil, Orla Howe, Paul Cahill, Hugh J. Byrne. https://www.sciencedirect.com/science/article/pii/S2212877822002046

Cytosolic lipolysis in non‐adipose tissues: energy provision and beyond – Siyu Chen, Xun Huang. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16161

Iron and liver cancer: an inseparable connection – Keisuke Hino, Izumi Yanatori, Yuichi Hara, Sohji Nishina. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16208

Emerging roles of ferroptosis in infectious diseases – Salimata Bagayoko, Etienne Meunier. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16244

Obesity Programs Macrophages to Support Cancer Progression – Abhijeet Singh, Shyamananda Singh Mayengbam, Himanshi Yaduvanshi, Mohan R. Wani, Manoj Kumar Bhat. https://aacrjournals.org/cancerres/article-abstract/82/23/4303/710689

mTORC1 beyond anabolic metabolism: Regulation of cell death – Jiajun Zhu, Hua Wang, Xuejun Jiang. https://rupress.org/jcb/article/221/12/e202208103/213609

Tryptophan and its metabolites in normal physiology and cancer etiology – Lizbeth Perez-Castro, Roy Garcia, Niranjan Venkateswaran, Spencer Barnes, Maralice Conacci-Sorrell. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16245


Comments


Bicarbonate transport as a vulnerability in pancreatic cancer – Li Qiang and Stephanie K. Dougan. https://www.nature.com/articles/s43018-022-00492-w

Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors – Tanya Schild, Kayvan R. Keshari. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00520-7

Fat Fuels the Fire in Cervical Cancer – Kassidy M. Jungles, Michael D. Green. https://aacrjournals.org/cancerres/article-abstract/82/24/4513/711516

mTORC1 takes control of lysosomal lipid breakdown – Laura Tribouillard and Mathieu Laplante. https://www.nature.com/articles/s42255-022-00702-w

Beyond Warburg: LDHA activates RAC for tumour growth – Natsuski Osaka and Atsuo T. Sasaki. https://www.nature.com/articles/s42255-022-00709-3

Early immune pressure makes tumors metabolically stronger – Sujing Yuan, Hongbo Chi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00546-0

Illuminating lactate in cells, mice, and patient samples – Zefan Li, Hui-wang Ai. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00544-7

Suppression of CD8+ T cells by the metabolite itaconate – https://www.nature.com/articles/s42255-022-00694-7

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