Glucose/lactate
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase – Kevin G. Hicks, Ahmad A. Cluntun, Heidi L. Schubert, Sean R. Hackett, Jordan A. Berg, Paul G. Leonard, Mariana A. Ajalla Aleixo, Youjia Zhou, Alex J. Bott, Sonia R. Salvatore, Fei Chang, Aubrie Blevins, Paige Barta, Samantha Tilley, Aaron Leifer, Andrea Guzman, Ajak Arok, Sarah Fogarty, Jacob M. Winter, Hee-Chul Ahn, Karen N. Allen, Samuel Block, Iara A. Cardoso, Jianping Ding, Ingrid Dreveny, William C. Gasper, Quinn Ho, Atsushi Matsuura, Michael J. Palladino, Sabin Prajapati, Pengkai Sun, Kai Tittmann, Dean R. Tolan, Judith Unterlass, Andrew P. VanDemark, Matthew G. Vander Heiden, Bradley A. Webb, Cai-Hong Yun, Pengkai Zhao, Bei Wang, Francisco J. Schopfer, Christopher P. Hill, Maria Cristina Nonato, Florian L. Muller, James E. Cox, Jared Rutter. https://www.science.org/doi/abs/10.1126/science.abm3452
Lactate regulates cell cycle by remodeling the anaphase promoting complex – Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien Tran, Sally Winther, Stephen M. Hinshaw, Jingnan Shen, Hyuk-Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Jean Zhao, Sirano Dhe-Paganon, Jianwei Che, Steven P. Gygi, Haribabu Arthanari and Edward T. Chouchani. https://www.nature.com/articles/s41586-023-05939-3
Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells – Leixi Cao, Ruijie Wang, Guangzhi Liu, Yuwei Zhang, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Yang Xia, Lili Guo, Fengmin Shao, Hao Gu, Mian Wu. https://www.embopress.org/doi/abs/10.15252/embr.202255683
Cystine / Glutathione / NAD(P)
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer – Tommy Weiss-Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar, Cong-Hui Yao, Adriaan de Groot, Stefan Harry, Alexander Carlin, Hannah Fischer, Lei Shi, Ting-Yu Wei, Charles H. Adelmann, Konstantin Wolf, Tristan Vornbäumen, Benedikt R. Dürr, Mariko Takahashi, Marianne Richter, Junbing Zhang, Tzu-Yi Yang, Vindhya Vijay, David E. Fisher, Aaron N. Hata, Marcia C. Haigis, Raul Mostoslavsky, Nabeel Bardeesy, Thales Papagiannakopoulos, Liron Bar-Peled. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00012-8
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis – Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V. Poyurovsky, M. James You, Traver Hart, Daniel D. Billadeau, Junjie Chen and Boyi Gan. https://www.nature.com/articles/s41556-023-01091-2
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism – Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell and Peter Canoll. https://www.nature.com/articles/s41467-023-36630-w
Other amino acids
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer – Min-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh, George Ye, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Megan T. Hoffman, Aladdin M. Bhuiyan, Jaimie L. Barth, Miranda E. Machacek, Mari Mino-Kenudson, Stephanie K. Dougan, Unmesh Jadhav, Clary B. Clish and Nada Y. Kalaany. https://www.nature.com/articles/s41586-023-05891-2
Serine and one-carbon metabolism sustain non-melanoma skin cancer progression – Angela Cappello, Alessandro Zuccotti, Mara Mancini, Giulia Tosetti, Luca Fania, Francesco Ricci, Gerry Melino and Eleonora Candi. https://www.nature.com/articles/s41420-023-01398-x
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy – Duo Zhang, Albert M. Li, Guanghui Hu, Menggui Huang, Fan Yang, Lin Zhang, Kathryn E. Wellen, Xiaowei Xu, Crystal S. Conn, Wei Zou, Mark Kahn, Seth D. Rhoades, Aalim M. Weljie, Serge Y. Fuchs, Nduka Amankulor, Daniel Yoshor, Jiangbin Ye, Constantinos Koumenis, Yanqing Gong, Yi Fan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00010-4
Lipid metabolism, nucleotides
Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis – Abhijit B. Shinde, Elizabeth R. Nunn, Genesis A. Wilson, Mathew T. Chvasta, Julia A. Pinette, Jacob W. Myers, Sun H. Peck, Jessica B. Spinelli, Elma Zaganjor. https://www.jbc.org/article/S0021-9258(23)00277-6/fulltext
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition – Qiaoyun Chu, Jing An, Ping Liu, Yihan Song, Xuewei Zhai, Ronghui Yang, Jing Niu, Chuanzhen Yang, Binghui Li. https://rupress.org/jem/article/220/3/e20221316/213757
Mitochondria
Spatial mapping of mitochondrial networks and bioenergetics in lung cancer – Mingqi Han, Eric A. Bushong, Mayuko Segawa, Alexandre Tiard, Alex Wong, Morgan R. Brady, Milica Momcilovic, Dane M. Wolf, Ralph Zhang, Anton Petcherski, Matthew Madany, Shili Xu, Jason T. Lee, Masha V. Poyurovsky, Kellen Olszewski, Travis Holloway, Adrian Gomez, Maie St. John, Steven M. Dubinett, Carla M. Koehler, Orian S. Shirihai, Linsey Stiles, Aaron Lisberg, Stefano Soatto, Saman Sadeghi, Mark H. Ellisman and David B. Shackelford. https://www.nature.com/articles/s41586-023-05793-3
Fumarate induces vesicular release of mtDNA to drive innate immunity – Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M. N. Wortel, Jordan L. Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S. H. Costa, Gonçalo C. Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas Mitchell, Mark Johnson, Julien Prudent and Christian Frezza. https://www.nature.com/articles/s41586-023-05770-w
Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells – Madeleine L Hart, Evan Quon, Anna-Lena BG Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sullivan. https://elifesciences.org/articles/78654
Starvation
cAMP-Protein kinase A and stress-activated MAP kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation – Armando Jesús Pérez-Díaz, Beatriz Vázquez-Marín, Jero Vicente-Soler, Francisco Prieto-Ruiz, Teresa Soto, Alejandro Franco, José Cansado and Marisa Madrid. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2125204
mTOR
Targeting NFE2L2/KEAP1 Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228 – Paul K. Paik, Pang-Dian Fan, Besnik Qeriqi, Azadeh Namakydoust, Bobby Daly, Linda Ahn, Rachel Kim, Andrew Plodkowski, Ai Ni, Jason Chang, Rachel Fanaroff, Marc Ladanyi, Elisa de Stanchina, Charles M. Rudin. https://www.jto.org/article/S1556-0864(22)01825-1
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion – Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J. Freeman, David J. Kwiatkowski and Elizabeth P. Henske. https://www.nature.com/articles/s41467-023-36881-7
Arf5-mediated regulation of mTORC1 at the plasma membrane – Christian Makhoul, Fiona J. Houghton, Elizabeth Hinde, and Paul A. Gleeson. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E22-07-0302
Hypoxia
An optimized reporter of the transcription factor hypoxia-inducible factor 1α reveals complex HIF-1α activation dynamics in single cells – Stevan Jeknić, Takamasa Kudo, Joanna J. Song, Markus W. Covert. https://www.jbc.org/article/S0021-9258(23)00241-7/fulltext
MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming – Shashi Anand, Mohammad Aslam Khan, Haseeb Zubair, Sarabjeet Kour Sudan, Kunwar Somesh Vikramdeo, Sachin Kumar Deshmukh, Shafquat Azim, Sanjeev Kumar Srivastava, Seema Singh, Ajay Pratap Singh. https://www.embopress.org/doi/abs/10.15252/embr.202255643
Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis – Joseph A Garcia, Rui Chen, Min Xu, Sarah A Comerford, Robert E Hammer, Shelby D Melton, Linda A Feagins. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282223
IDH
Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial – Ingo K. Mellinghoff, Min Lu, Patrick Y. Wen, Jennie W. Taylor, Elizabeth A. Maher, Isabel Arrillaga-Romany, Katherine B. Peters, Benjamin M. Ellingson, Marc K. Rosenblum, Saewon Chun, Kha Le, Ania Tassinari, Sung Choe, Youssef Toubouti, Steven Schoenfeld, Shuchi S. Pandya, Islam Hassan, Lori Steelman, Jennifer L. Clarke and Timothy F. Cloughesy. https://www.nature.com/articles/s41591-022-02141-2
Cancer Immunometabolism
The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation – Xuyong Chen, Lingling Liu, Siwen Kang, JN Rashida Gnanaprakasam, Ruoning Wang. https://www.science.org/doi/full/10.1126/sciadv.add955
Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions – Leticia Soriano-Baguet, Melanie Grusdat, Henry Kurniawan, Mohaned Benzarti, Carole Binsfeld, Anouk Ewen, Joseph Longworth, Lynn Bonetti, Luana Guerra, Davide G. Franchina, Takumi Kobayashi, Veronika Horkova, Charlène Verschueren, Sergio Helgueta, Deborah Gérard, Tushar H. More, Antonia Henne, Catherine Dostert, Sophie Farinelle, Antoine Lesur, Jean-Jacques Gérardy, Christian Jäger, Michel Mittelbronn, Lasse Sinkkonen, Karsten Hiller, Johannes Meiser, Dirk Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00164-X
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses – Fabio Zani, Julianna Blagih, Tim Gruber, Michael D. Buck, Nicholas Jones, Marc Hennequart, Clare L. Newell, Steven E. Pilley, Pablo Soro-Barrio, Gavin Kelly, Nathalie M. Legrave, Eric C. Cheung, Ian S. Gilmore, Alex P. Gould, Cristina Garcia-Caceres and Karen H. Vousden. https://www.nature.com/articles/s41586-023-05801-6
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production – Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado-Carrancio, Alva M. Casey, Hiran A. Prag, Ana S. H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander Von Kriegsheim, Michael P. Murphy, Caroline Jefferies, Christian Frezza and Luke A. J. O’Neill. https://www.nature.com/articles/s41586-023-05720-6
Neutralization of NET-associated human ARG1 enhances cancer immunotherapy – Stefania Canè, Roza Maria Barouni, Marina Fabbi, John Cuozzo, Giulio Fracasso, Annalisa Adamo, Stefano Ugel, Rosalinda Trovato, Francesco De Sanctis, Mauro Giacca, Rita Lawlor, Aldo Scarpa, Borislav Rusev, Gabriella Lionetto, Salvatore Paiella, Roberto Salvia, Claudio Bassi, Susanna Mandruzzato, Silvano Ferrini, Vincenzo Bronte. https://www.science.org/doi/abs/10.1126/scitranslmed.abq6221
PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages – Maaike Schilperoort, David Ngai, Marina Katerelos, David A. Power and Ira Tabas. https://www.nature.com/articles/s42255-023-00736-8
Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers – Jinfen Wei, Wenqi Yu, Juanzhi Chen, Guanda Huang, Lingjie Zhang, Zixi Chen, Meiling Hu, Xiaocheng Gong, Hongli Du. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13373
Characterization of the effect of the GLUT-1 inhibitor BAY-876 on T cells and macrophages – Ziyi Chen, Martin Vaeth, Miriam Eckstein, Murilo Delgobo, Gustavo Ramos, Stefan Frantz, Ulrich Hofmann, Nadine Gladow. https://www.sciencedirect.com/science/article/pii/S0014299923000638?via%3Dihub
Reviews
Regulation of nucleotide metabolism in cancers and immune disorders – Eunus S. Ali, Issam Ben-Sahra. https://www.sciencedirect.com/science/article/pii/S0962892423000442
New insights into activation and function of the AMPK – Gregory R. Steinberg and D. Grahame Hardie. https://www.nature.com/articles/s41580-022-00547-x
Metabolic programming and immune suppression in the tumor microenvironment – Emily N. Arner, Jeffrey C. Rathmell. https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00009-0
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies – Dimitri Vanauberg, Céline Schulz and Tony Lefebvre. https://www.nature.com/articles/s41389-023-00460-8
HIF: a master regulator of nutrient availability and metabolic cross‐talk in the tumor microenvironment – Rindert Missiaen, Nicholas P Lesner, M Celeste Simon. https://www.embopress.org/doi/abs/10.15252/embj.2022112067
Metabolic sensing and control in mitochondria – Yuyang Liu, Kıvanç Birsoy. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00119-3
SnapShot: Mitochondrial signaling – Taylor A. Poor, Navdeep S. Chandel. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00028-X
Comments
Mitochondrial molecule controls inflammation – Taylor A. Poor, Navdeep S. Chandel. https://www.nature.com/articles/d41586-023-00596-y
Mitochondria in cancer: clean windmills or stressed tinkerers? – Dario C. Altieri. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00191-X
Glycolysis modulates efferocytosis in a noncanonical manner – Monara Kaélle Sérvulo Cruz Angelim and Pedro M. Moraes-Vieira. https://www.nature.com/articles/s42255-023-00746-6
HK2: Gatekeeping microglial activity by tuning glucose metabolism and mitochondrial functions – Jing Fang, Shudi Luo, Zhimin Lu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00149-1
Nutrient priming of the pre-metastatic niche – Daniela Senft. https://www.nature.com/articles/s41568-023-00559-5
Cancer cachexia: involvement of an expanding macroenvironment – Benjamin R. Pryce, David J. Wang, Teresa A. Zimmers, Michael C. Ostrowski, Denis C. Guttridge. https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00035-1
A metabolic vulnerability of pancreatic cancer – Daniel J. Puleston. https://www.nature.com/articles/d41586-023-00848-x
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer – Emily J. Kay, Sara Zanivan. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13400
Unanticipated metabolic plasticity in response to chronic hypoxia – Ioanna Papandreou, Martin Benej, Nicholas C. Denko. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00047-5
Metabolism and Cancer articles 