Hexose / lactate metabolism
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma – Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley. https://aacrjournals.org/cancerdiscovery/article/13/4/1002/725028/LKB1-Dependent-Regulation-of-TPI1-Creates-a
Lactate regulates cell cycle by remodelling the anaphase promoting complex – Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick D. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien Tran, Sally Winther, Stephen M. Hinshaw, Jingnan Shen, Hyuk-Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Jean J. Zhao, Sirano Dhe-Paganon, Jianwei Che, Steven P. Gygi, Haribabu Arthanari and Edward T. Chouchani. https://www.nature.com/articles/s41586-023-05939-3
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation – Qingxia Ma, Hongfei Jiang, Leina Ma, Gaoxiang Zhao, Qianqian Xu, Dong Guo, Ningning He, Hao Liu, Zhaoyuan Meng, Juanjuan Liu, Lei Zhu, Qian Lin, Xiaolin Wu, Min Li, Shudi Luo, Jing Fang, and Zhimin Lu. https://www.pnas.org/doi/10.1073/pnas.2209435120
The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells – Deepti Talwar, Colin G. Miller, Justus Grossmann, Lukasz Szyrwiel, Torsten Schwecke, Vadim Demichev, Ana-Matea Mikecin Drazic, Anand Mayakonda, Pavlo Lutsik, Carmen Veith, Michael D. Milsom, Karin Müller-Decker, Michael Mülleder, Markus Ralser and Tobias P. Dick. https://www.nature.com/articles/s42255-023-00781-3
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death – Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, Céline Philippe, Vilma Dembitz, Aoife M. S. Magee, Ryan Asby, Louie N. van de Lagemaat, Christopher Mapperley, Sophie C. James, Jochen H. M. Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly and Paolo Gallipoli. https://www.nature.com/articles/s41467-023-37652-0
Lipid metabolism
An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation – Samantha G. Scharenberg, Wentao Dong, Ali Ghoochani, Kwamina Nyame, Roni Levin-Konigsberg, Aswini R. Krishnan, Eshaan S. Rawat, Kaitlyn Spees, Michael C. Bassik, Monther Abu-Remaileh. https://www.science.org/doi/full/10.1126/sciadv.adf8966
A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA – Carlos Cruz-Cortés, M. Andrés Velasco-Saavedra, Eli Fernández-de Gortari, Guadalupe Guerrero-Serna, Rodrigo Aguayo-Ortiz, L. Michel Espinoza-Fonseca. https://www.jbc.org/article/S0021-9258(23)00323-X
Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion – Ceren Duman, Barbara Di Marco, Ekaterina Nevedomskaya, Berk Ulug, Ralf Lesche, Sven Christian and Julieta Alfonso. https://www.nature.com/articles/s41419-023-05813-0
Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis – Wei Zhou, Heng Liu, Zhe Yuan, Joseph Zundell, Martina Towers, Jianhuang Lin, Simona Lombardi, Hao Nie, Brennah Murphy, Tyler Yang, Chen Wang, Liping Liao, Aaron R. Goldman, Toshitha Kannan, Andrew V. Kossenkov, Ronny Drapkin, Luis J. Montaner, Daniel T. Claiborne, Nan Zhang, Shuai Wu, Rugang Zhang. https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00050-8
Mitochondria
Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase-deficient renal cell carcinoma – Liang Zheng, Zi-Ran Zhu, Tal Sneh, Weituo Zhang, Zao-Yu Wang, Guang-Yu Wu, Wei He, Hong-Gang Qi, Hang Wang, Xiao-Yu Wu, Jonatan Fernández-García, Ifat Abramovich, Yun-Ze Xu, Jin Zhang, Eyal Gottlieb. https://www.jci.org/articles/view/165028
Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer – Subhadip Mukhopadhyay, Joel Encarnación-Rosado, Elaine Y. Lin, Albert S. W. Sohn, Huan Zhang, Joseph D. Mancias, Alec C. Kimmelman. https://www.science.org/doi/full/10.1126/sciadv.adf9284
Starvation
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1 – Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw. https://www.science.org/doi/abs/10.1126/science.abj5559
EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation – Marcella Cesana ,Gennaro Tufano, Francesco Panariello, Nicolina Zampelli, Susanna Ambrosio, Rossella De Cegli, Margherita Mutarelli, Lorenzo Vaccaro, Micheal J. Ziller, Davide Cacchiarelli, Diego L. Medina, Andrea Ballabio. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002034
Sestrin2-mediated disassembly of stress granules dampens aerobic glycolysis to overcome glucose starvation – Mingyue Li, Rick Francis Thorne, Ruijie Wang, Leixi Cao, Fangyuan Cheng, Xuedan Sun, Mian Wu, Jianli Ma and Lianxin Liu. https://www.nature.com/articles/s41420-023-01411-3
The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures – Leila Fusée, Norman Salomao, Anand Ponnuswamy, Lixiao Wang, Ignacio López, Sa Chen, Xiaolian Gu, Stavros Polyzoidis, Sivakumar Vadivel Gnanasundram and Robin Fahraeus. https://www.nature.com/articles/s41418-023-01127-y
AMPK activation protects against prostate cancer by inducing a catabolic cellular state – Lucy Penfold, Angela Woods, Alice E. Pollard, Julia Arizanova, Eneko Pascual-Navarro, Phillip J. Muckett, Marian H. Dore, Alex Montoya, Chad Whilding, Louise Fets, Joao Mokochinski, Theodora A. Constantin, Anabel Varela-Carver, Damien A. Leach, Charlotte L. Bevan, Alexander Yu. Nikitin, Zoe Hall, David Carling. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00407-2
Hypoxia
Toward quantification of hypoxia using fluorinated EuII/III-containing ratiometric probes – A. Amali S. Subasinghe, Caitlyn J. Ortiz, Jonathan Romero, Cassandra L. Ward, Alexander G. Sertage, Lyazat Kurenbekova, Jason T. Yustein, Robia G. Pautler, and Matthew J. Allen. https://www.pnas.org/doi/10.1073/pnas.2220891120
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia – Angeliki Karagiota, Amalia Kanoura, Efrosyni Paraskeva, George Simos, Georgia Chachami. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16694
IDH
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis – Sho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino-Sakamoto, Naoya Sakamoto, Ken-ichi Yasumoto, Keiichi Okano, Yasuyuki Suzuki, Shinichi Yachida, Masahiro Aoki and Tomoyoshi Soga. https://www.nature.com/articles/s41388-023-02632-7
Cancer Immunometabolism
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity – Carina B. Nava Lauson, Silvia Tiberti, Paola A. Corsetto, Federica Conte, Punit Tyagi, Markus Machwirth, Stefan Ebert, Alessia Loffreda, Lukas Scheller, Dalia Sheta, Zeinab Mokhtari, Timo Peters, Ayush T. Raman, Francesco Greco, Angela M. Rizzo, Andreas Beilhack, Giovanni Signore, Nicola Tumino, Paola Vacca, Liam A. McDonnell, Andrea Raimondi, Philip D. Greenberg, Johannes B. Huppa, Simone Cardaci, Ignazio Caruana, Simona Rodighiero, Luigi Nezi, Teresa Manzo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00049-9
Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment – Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Surya P. Pandey, Colin R. Laughlin, Jake H. Shapira, Luzmariel Medina Sanchez, Mohit Rana, Tanner G. Richie, Tahliyah S. Mims, Angela M. Gocher-Demske, Luisa Cervantes-Barragan, Steven J. Mullett, Stacy L. Gelhaus, Tullia C. Bruno, Nikki Cannon, John A. McCulloch, Dario A.A. Vignali, Reinhard Hinterleitner, Alok V. Joglekar, Joseph F. Pierre, Sonny T.M. Lee, Diwakar Davar, Hassane M. Zarour, Marlies Meisel. https://www.cell.com/cell/fulltext/S0092-8674(23)00271-4
Cachexia
NAD+ repletion with niacin counteracts cancer cachexia – Marc Beltrà, Noora Pöllänen, Claudia Fornelli, Kialiina Tonttila, Myriam Y. Hsu, Sandra Zampieri, Lucia Moletta, Samantha Corrà, Paolo E. Porporato, Riikka Kivelä, Carlo Viscomi, Marco Sandri, Juha J. Hulmi, Roberta Sartori, Eija Pirinen and Fabio Penna. https://www.nature.com/articles/s41467-023-37595-6
Miscellaneous
Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress – Kazuya Nishio, Tomoyuki Kawarasaki, Yuki Sugiura, Shunsuke Matsumoto, Ayano Konoshima, Yuki Takano, Mayuko Hayashi, Fumihiko Okumura, Takumi Kamura, Tsunehiro Mizushima, Kunio Nakatsukasa. https://www.science.org/doi/full/10.1126/sciadv.adf1956
Reviews
What is cancer metabolism? – Lydia W.S. Finley. https://www.cell.com/cell/fulltext/S0092-8674(23)00097-1
Plasticity of cancer invasion and energy metabolism – Maria Parlani, Carolina Jorgez, Peter Friedl. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00231-8
Nucleotide metabolism: a pan-cancer metabolic dependency – Nicholas J. Mullen and Pankaj K. Singh. https://www.nature.com/articles/s41568-023-00557-7
Cachexia: A systemic consequence of progressive, unresolved disease – Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O’Rahilly, Norbert Perrimon, Eileen P. White, Tobias Janowitz. https://www.cell.com/cell/fulltext/S0092-8674(23)00325-2
Comments
Palmitate paves the way to lung metastasis – Alina M. Winkelkotte, Almut Schulze. https://www.cell.com/trends/cancer/fulltext/S2405-8033(23)00030-4
A metabolic vulnerability of pancreatic cancer – Daniel J. Puleston. https://www.nature.com/articles/d41586-023-00848-x
Fueling the Tumor Microenvironment with Cancer-Associated Adipocytes – Caroline Bouche, Daniela F. Quail. https://aacrjournals.org/cancerres/article/83/8/1170/725105
GAPDH redox redux—rewiring pentose phosphate flux – Laura Torrente and Gina M. DeNicola. https://www.nature.com/articles/s42255-021-00523-3
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction – Anna S. Monzel, José Antonio Enríquez and Martin Picard. https://www.nature.com/articles/s42255-023-00783-1
Overlooked confounding in studies of metabolite salts – https://www.nature.com/articles/s42255-023-00787-x
Tryptophan metabolite improves PDAC response rates and survival – Caroline Barranco. https://www.nature.com/articles/s41568-023-00566-6
Learning the metabolic language of cancer – Minervo Perez, Jordan L. Meier. https://www.nature.com/articles/d41586-023-01024-x
Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report – Jennifer Cable, Jeffrey C. Rathmell, Erika L. Pearce, Ping-Chih Ho, Marcia C. Haigis, Murad R. Mamedov, Meng-Ju Wu, Susan M. Kaech, Lydia Lynch, Mark A. Febbraio, Sagar P. Bapat, Hanna S. Hong, Weiping Zou, Yasmine Belkaid, Zuri A. Sullivan, Andrea Keller, Stefanie K. Wculek, Douglas R. Green, Catherine Postic, Ido Amit, Salvador Aznar Benitah, Russell G. Jones, Miguel Reina-Campos, Santiago Valle Torres, Semir Beyaz, Donal Brennan, Luke A. J. O’Neill, Rachel J. Perry, Dirk Brenner. https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.14976
Translocating Lactobacillus torments tumors via tryptophan catabolism – Márcia S. Pereira, Martin A. Kriegel. https://www.cell.com/cell/fulltext/S0092-8674(23)00285-4
Conferences:
“Understanding cancer metabolism: exploring tumour heterogeneity to advance cancer therapy” . 29–30 June 2023, Catanzaro, Italy. https://www.3bdtworkshop.it/
Metabolism and Cancer articles 