MetaboList – August 2021

Dear all,

registrations and abstract submission are still open for two meetings in autumn in the Barcelona area:

EMBO Cancer Immunometabolism

https://meetings.embo.org/event/21-cancer – fellowships available

7th MetNet International annual meeting

https://scb.iec.cat/7th-metnet-international-annual-meeting-2021/

Both can be attended remotely online.

Best,

Cristina


Glucose metabolism


UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth – Andrew L. Wolfe, Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A. Ku, Richard P. Koche, Sourav Bandyopadhyay, Maurizio Scaltriti, Carlito B. Lebrilla, Frank McCormick, and Sung Eun Kim. https://www.pnas.org/content/118/31/e2103592118.abstract?etoc

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition – Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya’an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao and Haoqiang Ying. https://cancerres.aacrjournals.org/content/81/15/4054

The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer – Pei Yu, Xiong Zhu, Jia-Le Zhu, Yu-Bao Han, Hao Zhang, Xiang Zhou, Lei Yang, Yuan-Zheng Xia, Chao Zhang and Ling-Yi Kong. https://www.nature.com/articles/s41388-021-01933-z

Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes – Maria Apostolidi, Ioannis A. Vathiotis, Viswanathan Muthusamy, Patricia Gaule, Brandon M. Gassaway, David L. Rimm and Jesse Rinehart. https://cancerres.aacrjournals.org/content/81/16/4346

Thioredoxin reductase is a major regulator of metabolism in leukemia cells – Sheelarani Karunanithi, Ruifu Liu, Yongchun Hou, Giancarlo Gonzalez, Natasha Oldford, Anne Jessica Roe, Nethrie Idipilly, Kalpana Gupta, Chandra Sekhar Amara, Satwikreddy Putluri, Grace Kyueun Lee, Juan Valentin-Goyco, Lindsay Stetson, Stephen A. Moreton, Vasanta Putluri, Shyam M. Kavuri, Yogen Saunthararajah, Marcos de Lima, Gregory P. Tochtrop, Nagireddy Putluri and David N. Wald. https://www.nature.com/articles/s41388-021-01924-0

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria – Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Günther Jahreis, Ralf M. Zerbes, Katelyn O’Neill, Martin van der Laan, Xu Luo, and Frank Edlich. https://www.pnas.org/content/118/33/e2021175118.abstract


Amino acid metabolism


GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis – Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive and Costas A. Lyssiotis. https://www.nature.com/articles/s41467-021-24859-2

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis – Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad del Socorro Murdoch, Victor H. Villar and Raúl V. Durán. https://www.nature.com/articles/s41467-021-25079-4

The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer – Alexandra Giatromanolaki, Adrian L. Harris and Michael I. Koukourakis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00264-7

Snail enhances arginine synthesis by inhibiting ubiquitination‐mediated degradation of ASS1 – Hao Jia, Yuquan Yang, Mengying Li, Yimin Chu, Huan Song, Jie Zhang, Dan Zhang, Qun Zhang, Ying Xu, Jiamin Wang, Hong Xu, Xiuqun Zou, Haixia Peng, Zhaoyuan Hou. https://www.embopress.org/doi/abs/10.15252/embr.202051780

Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase – Ronghui Yang, Zihao Guo, Yiliang Zhao, Lingdi Ma, Binghui Li and Chuanzhen Yang. https://www.nature.com/articles/s41420-021-00590-1


Lipid metabolism


Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance – Sze Kiat Tan, Iqbal Mahmud, Flavia Fontanesi, Michelle Puchowicz, Chase K.A. Neumann, Anthony J. Griswold, Rutulkumar Patel, Marco Dispagna, Hamzah H. Ahmed, Mark L. Gonzalgo, J. Mark Brown, Timothy J. Garrett and Scott M. Welford. https://cancerdiscovery.aacrjournals.org/content/11/8/2072

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy – Magali Humbert, Kristina Seiler, Severin Mosimann, Vreni Rentsch, Katyayani Sharma, Amit V. Pandey, Sharon L. McKenna and Mario P. Tschan. https://www.nature.com/articles/s41418-021-00768-1

Gut Microbiota–Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling – Makoto Matsushita, Kazutoshi Fujita, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Kentaro Jingushi, Gaku Yamamichi, Satoru Yumiba, Eisuke Tomiyama, Yoko Koh, Yujiro Hayashi, Kosuke Nakano, Cong Wang, Yu Ishizuya, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Maria D.C. Rodriguez Pena, Jennifer B. Gordetsky, George J. Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda and Norio Nonomura. https://cancerres.aacrjournals.org/content/81/15/4014

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies – Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan and Rosalie C. Sears. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00263-8

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects – Emeline Dierge, Elena Debock, Céline Guilbaud, Cyril Corbet, Eric Mignolet, Louise Mignard, Estelle Bastien, Chantal Dessy, Yvan Larondelle, Olivier Feron. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00233-3

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer – Wen Liu, Binita Chakraborty, Rachid Safi, Dmitri Kazmin, Ching-yi Chang and Donald P. McDonnell. https://www.nature.com/articles/s41467-021-25354-4


Nucleotides and one carbon


Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification – Thanh H. Nguyen, Prasantha L. Vemu, Gregory E. Hoy, Salah Boudjadi, Bishwanath Chatterjee, Jack F. Shern, Javed Khan, Wenyue Sun, and Frederic G. Barr. https://www.jci.org/articles/view/138022

Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression – Nora Pällmann, Ke Deng, Marte Livgård, Martina Tesikova, Yixin Jin, Nicolai Sebastian Frengen, Nermin Kahraman, Hamada M. Mokhlis, Bulent Ozpolat, Wanja Kildal, Havard Emil Danielsen, Ladan Fazli, Paul S. Rennie, Partha P. Banerjee, Aykut Üren, Yang Jin, Omer F. Kuzu and Fahri Saatcioglu. https://cancerres.aacrjournals.org/content/81/15/4066

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma – Yajie Yu, Jane Ding, Shunqin Zhu, Ahmet Alptekin, Zheng Dong, Chunhong Yan, Yunhong Zha and Han-Fei Ding. https://www.nature.com/articles/s41419-021-04120-w


Mitochondria


Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia – Junyan Lu, Ester Cannizzaro, Fabienne Meier-Abt, Sebastian Scheinost, Peter-Martin Bruch, Holly A. R. Giles, Almut Lütge, Jennifer Hüllein, Lena Wagner, Brian Giacopelli, Ferran Nadeu, Julio Delgado, Elías Campo, Maurizio Mangolini, Ingo Ringshausen, Martin Böttcher, Dimitrios Mougiakakos, Andrea Jacobs, Bernd Bodenmiller, Sascha Dietrich, Christopher C. Oakes, Thorsten Zenz and Wolfgang Huber. https://www.nature.com/articles/s43018-021-00216-6

International initiative for a curated SDHB variant database improving the diagnosis of hereditary paraganglioma and pheochromocytoma – Laurene Ben Aim, Eamonn R Maher, Alberto Cascon, Anne Barlier, Sophie Giraud, Tonino Ercolino6, Pascal Pigny, Roderick J Clifton-Bligh8, Delphine Mirebeau-Prunier, Amira Mohamed, Judith Favier, Anne-Paule Gimenez-Roqueplo, Francesca Schiavi1, Rodrigo A Toledo, Patricia L Dahia, Mercedes Robledo, Jean Pierre Bayley, Nelly Burnichon. https://jmg.bmj.com/content/early/2021/08/26/jmedgenet-2020-107652


mTOR / AMPK


The TOR‐dependent phosphoproteome and regulation of cellular protein synthesis – Tiffany Mak, Andrew W Jones, Paul Nurse. https://www.embopress.org/doi/full/10.15252/embj.2021107911

AMPKα loss promotes KRAS-mediated lung tumorigenesis – Manuela La Montagna, Lei Shi, Peter Magee, Sudhakar Sahoo, Matteo Fassan and Michela Garofalo. https://www.nature.com/articles/s41418-021-00777-0

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965 – Danial Ahwazi; Katyayanee Neopane; Greg R. Markby; Franziska Kopietz; Ashley J. Ovens ; Morten Dall; Anna S. Hassing; Pamina Gräsle; Yazeed Alshuweishi; Jonas T. Treebak ; Ian P. Salt; Olga Göransson; Elton Zeqiraj; John W. Scott; Kei Sakamoto. https://portlandpress.com/biochemj/article/478/15/2977/229245/Investigation-of-the-specificity-and-mechanism-of


Hypoxia


Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization – Yufeng Wang , Yajing Lyu, Kangsheng Tu, Qiuran Xu, Yongkang Yang, Shaima Salman, Nguyet Le, Haiquan Lu, Chelsey Chen, Yayun Zhu, Ru Wang, Qingguang Liu, Gregg L. Semenza. https://advances.sciencemag.org/content/7/35/eabe3771

Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer – Vineet K. Gupta, Nikita S. Sharma, Brittany Durden, Vanessa T. Garrido, Kousik Kesh, Dujon Edwards, Dezhen Wang, Ciara Myer, Beatriz Mateo-Victoriano, Sai Sundeep Kollala, Yuguang Ban, Zhen Gao, Sanjoy K. Bhattacharya, Ashok Saluja, Pankaj K. Singh and Sulagna Banerjee. https://cancerres.aacrjournals.org/content/81/15/4001


Cancer Immunometabolism


Standardized Uptake Value for 18F-Fluorodeoxyglucose Is a Marker of Inflammatory State and Immune Infiltrate in Cervical Cancer – John M. Floberg, Jin Zhang, Naoshad Muhammad, Todd A. DeWees, Matthew Inkman, Kevin Chen, Alexander J. Lin, Ramachandran Rashmi, Kay Jayachandran, Brian T. Edelson, Barry A. Siegel, Farrokh Dehdashti, Perry W. Grigsby, Stephanie Markovina and Julie K. Schwarz. https://clincancerres.aacrjournals.org/content/27/15/4245


Miscellaneous


O-GlcNAcylated p53 in the liver modulates hepatic glucose production – Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D. Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M. Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck and Ruben Nogueiras. https://www.nature.com/articles/s41467-021-25390-0

Diabetes Risk Reduction Diet and Survival after Breast Cancer Diagnosis – Tengteng Wang, Maryam S. Farvid, Jae H. Kang, Michelle D. Holmes, Bernard A. Rosner, Rulla M. Tamimi, Walter C. Willett and A. Heather Eliassen. https://cancerres.aacrjournals.org/content/81/15/4155

Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma – Sureerat Padthaisong, Jutarop Phetcharaburanin, Poramate Klanrit, Jia V. Li, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Arporn Wangwiwatsin, Panupong Mahalapbutr and Watcharin Loilome. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00266-5

Inflammatory metabolic profile of South African patients with prostate cancer – Stefano Cacciatore, Martha Wium, Cristina Licari, Aderonke Ajayi-Smith, Lorenzo Masieri, Chanelle Anderson, Azola Samkele Salukazana, Lisa Kaestner, Marco Carini, Giuseppina M. Carbone, Carlo V. Catapano, Massimo Loda, Towia A. Libermann and Luiz F. Zerbini. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00265-6

Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration – Le Qi, Misty S. Martin-Sandoval, Salma Merchant, Wen Gu, Matthias Eckhardt, Thomas P. Mathews, Zhiyu Zhao, Michalis Agathocleous, Sean J. Morrison. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00296-4


Reviews


The context-specific roles of urea cycle enzymes in tumorigenesis – Emma Haja,, Marco Sciacovelli, Christian Frezza, Ayelet Erez. https://www.sciencedirect.com/science/article/abs/pii/S1097276521006456

Autophagy is a major metabolic regulator involved in cancer therapy resistance – Laura Poillet-Perez, Jean-Emmanuel Sarry, Carine Joffre. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00959-1

Metabolic reprogramming in renal cancer: Events of a metabolic disease – Samik Chakraborty, Murugabaskar Balan, Akash Sabarwal, Toni K. Choueiri, Soumitro Pal. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000561

Recent advancements in therapeutic targeting of the Warburg effect in refractory ovarian cancer: A promise towards disease remission – Komal Tyagi, Supratim Mandal, Adhiraj Roy. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000603

Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy – Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan. https://www.sciencedirect.com/science/article/abs/pii/S0304419X21000652

The immunological and metabolic landscape in primary and metastatic liver cancer – Xin Li, Pierluigi Ramadori, Dominik Pfister, Marco Seehawer, Lars Zender and Mathias Heikenwalder. https://www.nature.com/articles/s41568-021-00383-9

Exploring the therapeutic potential of mitochondrial uncouplers in cancer – Riya Shrestha, Edward Johnson, Frances L. Byrne. https://www.sciencedirect.com/science/article/pii/S2212877821000661


Comments


How the amino acid leucine activates the key cell-growth regulator mTOR – Tibor Vellai. https://www.nature.com/articles/d41586-021-01943-7

RAG-ulating mTORC1 with amino acids – Jenna L. Jewell. https://www.nature.com/articles/s41580-021-00378-2

Multiplexed suppression of TOR complex 1 induces autophagy during starvation – Tomoyuki Fukuda and Kazuhiro Shiozaki. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1938915

An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation – Ying Yang and Daniel J. Klionsky. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1959240

CD36 pumps fat to defang killer T cells in tumors – Manikandan Subramanian, Federica M. Marelli-Berg. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00320-X?dgcid=raven_jbs_etoc_email

Mechanisms of resistance to mitochondria-targeted therapy in pancreatic cancer – Stepana Boukalova, Zuzana Ezrova,  and Jiri Neuzil. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=5145010dcf&e=923b339f12

Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11high cancer cells – Xiaoguang Liu, and Boyi Gan. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=dde7eee63d&e=923b339f12

Excess Polyunsaturated Fatty Acids Induce Death in Acidic Cancer Cellshttps://cancerdiscovery.aacrjournals.org/content/11/8/1872.2

Metabolic mechanisms of medulloblastoma metastasis – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-021-00391-9

MetaboList – July 2021

 

Join us for an EMBO workshop on Cancer Immunometabolism near Barcelona! 

Early bird registration deadline August 15th.  See more details below.

 


Starvation / nutrient sensing


SAR1B senses leucine levels to regulate mTORC1 signalling – Jie Chen, Yuhui Ou, Rong Luo, Jie Wang, Dong Wang, Jialiang Guan, Yi Li, Peixue Xia, Peng R. Chen and Ying Liu. https://www.nature.com/articles/s41586-021-03768-w

RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal – Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00868-8

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner – Cansu Karabiyik, Mariella Vicinanza, Sung Min Son, David C. Rubinsztein. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00439-1

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness – Yijuan Zhang, M. Victoria Recouvreux, Michael Jung, Koen M.O. Galenkamp, Yunbo Li, Olga Zagnitko, David A. Scott, Andrew M. Lowy and Cosimo Commisso. https://cancerdiscovery.aacrjournals.org/content/11/7/1808


mTOR / AMPK


Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin – Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD.. https://www.sciencedirect.com/science/article/pii/S2212877821001563

Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs – Ana Ortega-Molina, Cristina Lebrero-Fernández, Alba Sanz, Nerea Deleyto-Seldas, Ana Belén Plata-Gómez, Camino Menéndez, Osvaldo Graña-Castro, Eduardo Caleiras, Alejo Efeyan. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00770-1

Gαq activation modulates autophagy by promoting mTORC1 signaling – Sofía Cabezudo, Maria Sanz-Flores, Alvaro Caballero, Inmaculada Tasset, Elena Rebollo, Antonio Diaz, Anna M. Aragay, Ana María Cuervo, Federico Mayor Jr and Catalina Ribas. https://www.nature.com/articles/s41467-021-24811-4

Structure of an AMPK complex in an inactive, ATP-bound state – Yan Yan, Somnath Mukherjee, Kaleeckal G. Harikumar, Timothy S. Strutzenberg, X. Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D. Sheldon, Jared Lamp, Joseph S. Brunzelle, Katarzyna Radziwon, Abigail Ellis, Scott J. Novick, Irving E. Vega, Russell G. Jones, Laurence J. Miller, H. Eric Xu, Patrick R. Griffin, Anthony A. Kossiakoff, Karsten Melcher. https://science.sciencemag.org/content/373/6553/413

Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2 – Christelle Harly , Stephen Paul Joyce, Charlotte Domblides, Thomas Bachelet, Vincent Pitard, Charlotte Mannat, Angela Pappalardo, Lionel Couzi, Sonia Netzer, Layal Massara, Emilie Obre, Omar Hawchar, Lydia Lartigue, Stéphane Claverol, Carla Cano, Jean-François Moreau, Isabelle Mahouche, Isabelle Soubeyran, Rodrigue Rossignol, Benoit Viollet, Carrie R. Willcox, Fiyaz Mohammed, Benjamin E. Willcox, Benjamin Faustin, Julie Déchanet-Merville.https://immunology.sciencemag.org/content/6/61/eaba9010


Hypoxia


Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy – Audrey Lequeux, Muhammad Zaeem Noman, Malina Xiao, Kris Van Moer, Meriem Hasmim, Alice Benoit, Manon Bosseler, Elodie Viry, Tsolere Arakelian, Guy Berchem, Salem Chouaib and Bassam Janji. https://www.nature.com/articles/s41388-021-01846-x

Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α – Leonard A. Daly , Philip J. Brownridge, Michael Batie, Sonia Rocha, Violaine Sée, Claire E. Eyers. https://stke.sciencemag.org/content/14/692/eabf6685


Glucose metabolism


Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect – Elizabeth K. Wiese, Sadae Hitosugi, Sharon T. Loa, Annapoorna Sreedhar, Lindsey G. Andres-Beck, Kiran Kurmi, Yuan-Ping Pang, Larry M. Karnitz, Wilson I. Gonsalves and Taro Hitosugi. https://www.nature.com/articles/s42255-021-00424-5

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs – Chia-Hung Chen, Bo-Wei Wang, Yu-Chun Hsiao, Chun-Yi Wu, Fang-Ju Cheng, Te-Chun Hsia, Chih-Yi Chen, Yihua Wang, Zhang Weihua, Ruey-Hwang Chou, Chih-Hsin Tang, Yun-Ju Chen, Ya-Ling Wei, Jennifer L. Hsu, Chih-Yen Tu, Mien-Chie Hung and Wei-Chien Huang. https://www.nature.com/articles/s41388-021-01889-0


Amino acid metabolism


Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition – George Sharbeen, Joshua A. McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R. Cox, Brooke A. Pereira, Jessica L. Chitty, Sigrid K. Fey, Arafath K. Najumudeen, Andrew D. Campbell, Owen J. Sansom, Rosa Mistica C. Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J. Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti V. Apte, Thomas P. Davis, Jennifer P. Morton, Koroush S. Haghighi, Jorjina Kasparian, Benjamin J. McLean, Yordanos F. Setargew; Australian Pancreatic Cancer Genome Initiative and Phoebe A. Phillips. https://cancerres.aacrjournals.org/content/81/13/3461

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis – Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu and Shu Li. https://www.nature.com/articles/s41467-021-24321-3

Structural and biochemical properties of L‐asparaginase – Jacek Lubkowski, Alexander Wlodawer. https://stm.sciencemag.org/content/13/604/eabb1069

Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway – Bingbing Dai, Jithesh J. Augustine, Ya’an Kang, David Roife, Xinqun Li, Jenying Deng, Lin Tan, Leona A. Rusling, John N. Weinstein, Philip L. Lorenzi, Michael P. Kim and Jason B. Fleming. https://www.nature.com/articles/s41419-021-03970-8


Lipid metabolism


SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis – Elma Zaganjor, Haejin Yoon, Jessica B. Spinelli, Elizabeth R. Nunn, Gaëlle Laurent, Paulina Keskinidis, Suganja Sivaloganathan, Shakchhi Joshi, Giulia Notarangelo, Stacy Mulei, Mathew T. Chvasta, Sarah A. Tucker, Krystle Kalafut, Robert A.H. van de Ven, Clary B. Clish, Marcia C. Haigis. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00721-X

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer – Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler and De-Chen Lin. https://www.nature.com/articles/s41467-021-24656-x


Nucleotides


p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage – Gen Li, Jun Wu, Le Li, and Peng Jiang. https://www.pnas.org/content/118/28/e2019822118.abstract?etoc

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia – Daniela Di Marcantonio, Esteban Martinez, Joice S. Kanefsky, Jacklyn M. Huhn, Rashid Gabbasov, Anushk Gupta, John J. Krais, Suraj Peri, YinFei Tan, Tomasz Skorski, Adrienne Dorrance, Ramiro Garzon, Aaron R. Goldman, Hsin-Yao Tang, Neil Johnson, Stephen M. Sykes. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00365-8

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells – Andrew J. Schwartz, Joshua W. Goyert, Sumeet Solanki, Samuel A. Kerk, Brandon Chen, Cristina Castillo, Peggy P. Hsu, Brian T. Do, Rashi Singhal, Michael K. Dame, Ho-Joon Lee, Jason R. Spence, Samira Lakhal-Littleton, Matthew G. Vander Heiden, Costas A. Lyssiotis, Xiang Xue and Yatrik M. Shah. https://www.nature.com/articles/s42255-021-00424-5

Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells – Xiangguo Shi , Yajian Jiang, Ayumi Kitano, Tianyuan Hu, Rebecca L. Murdaugh, Yuan Li, Kevin A. Hoegenauer, Rui Chen, Koichi Takahashi, Daisuke Nakada. https://advances.sciencemag.org/content/7/30/eabf3895


Mitochondria


Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate – Judith Goncalves, Sophie Moog, Aurélie Morin, Géraldine Gentric, Sebastian Müller, Alexander P. Morrell, Katarina Kluckova, Theodora J. Stewart, Cynthia L. Andoniadou, Charlotte Lussey-Lepoutre, Paule Bénit, Alpesh Thakker, Lisa Vettore, Jennie Roberts, Raphaël Rodriguez, Fatima Mechta-Grigoriou, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Daniel A. Tennant and Judith Favier. https://cancerres.aacrjournals.org/content/81/13/3480

BCL(X)L and BCL2 increase mitochondrial dynamics in breast cancer cell: Evidence from functional and genetic studies – Federico Lucantoni, Manuela Salvucci, Heiko Dussmann, Jochen H.M.Prehn. https://www.sciencedirect.com/science/article/abs/pii/S016748892100149X


Cancer Immunometabolism


Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors – Shihao Xu, Omkar Chaudhary, Patricia Rodríguez-Morales, Xiaoli Sun, Dan Chen, Roberta Zappasodi, Ziyan Xu, Antonio F.M. Pinto, April Williams, Isabell Schulze, Yagmur Farsakoglu, Siva Karthik Varanasi, Jun Siong Low, Wenxi Tang, Haiping Wang, Bryan McDonald, Victoria Tripple, Michael Downes, Ronald M. Evans, Nada A. Abumrad, Taha Merghoub, Jedd D. Wolchok, Maxim N. Shokhirev, Ping-Chih Ho, Joseph L. Witztum, Brinda Emu, Guoliang Cui, Susan M. Kaech. https://www.cell.com/immunity/fulltext/S1074-7613(21)00209-0

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation – Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, German R. Aleman-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sanchez-Lopez. https://www.cell.com/immunity/fulltext/S1074-7613(21)00210-7

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas – Mirco Friedrich, Roman Sankowski, Lukas Bunse, Michael Kilian, Edward Green, Carina Ramallo Guevara, Stefan Pusch, Gernot Poschet, Khwab Sanghvi, Markus Hahn, Theresa Bunse, Philipp Münch, Hagen M. Gegner, Jana K. Sonner, Anna von Landenberg, Frederik Cichon, Katrin Aslan, Tim Trobisch, Lucas Schirmer, Denis Abu-Sammour, Tobias Kessler, Miriam Ratliff, Daniel Schrimpf, Felix Sahm, Carsten Hopf, Dieter H. Heiland, Oliver Schnell, Jürgen Beck, Chotima Böttcher, Camila Fernandez-Zapata, Josef Priller, Sabine Heiland, Ilona Gutcher, Francisco J. Quintana, Andreas von Deimling, Wolfgang Wick, Marco Prinz and Michael Platten. https://www.nature.com/articles/s43018-021-00201-z


Miscellaneous


Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells – Kouichi Yanagi, Toru Komatsu, Shusuke Ogihara, Takayoshi Okabe, Hirotatsu Kojima, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00687-2

SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides – Yoshiki Ikeda, Akiyoshi Hirayama, Satoshi Kofuji, Yoshihisa Hirota, Ryo Kamata, Natsuki Osaka, Yuki Fujii, Mika Sasaki, Satsuki Ikeda, Eric P Smith, Robert Bachoo, Tomoyoshi Soga, Atsuo T Sasaki. https://academic.oup.com/jb/advance-article-abstract/doi/10.1093/jb/mvab077/6318401

Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma – Daniel J. Silver, Gustavo A. Roversi, Nazmin Bithi, Sabrina Z. Wang, Katie M. Troike, Chase K.A. Neumann, Grace K. Ahuja, Ofer Reizes, J. Mark Brown, Christopher Hine, Justin D. Lathia. https://www.jci.org/articles/view/138276

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine – Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri and Florian L. Muller. https://www.nature.com/articles/s41467-021-24240-3


Reviews


Cancer metabolism: looking forward – Inmaculada Martínez-Reyes and Navdeep S. Chandel. https://www.nature.com/articles/s41568-021-00378-6

The Complex Integration of T-cell Metabolism and Immunotherapy – Matthew Z. Madden, and Jeffrey C. Rathmell. https://cancerdiscovery.aacrjournals.org/content/11/7/1636

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment – Samuel A. Kerk, Thales Papagiannakopoulos, Yatrik M. Shah and Costas A. Lyssiotis. https://www.nature.com/articles/s41568-021-00375-9

Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer – Violet Y. Tu, Asma Ayari and Roddy S. O’Connor. https://www.mdpi.com/2073-4468/10/3/25/htm

The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species – Brandán Pedre, Uladzimir Barayeu, Daria Ezeriņa, Tobias P. Dick. https://www.sciencedirect.com/science/article/pii/S0163725821001182

Quantitative flux analysis in mammals – Caroline R Bartman, Tara TeSlaa, Joshua D Rabinowitz.. https://www.nature.com/articles/s42255-021-00419-2

Peroxisomes as cellular adaptors to metabolic and environmental stress – Anyuan He, John M. Dean, Irfan J. Lodhi. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00030-1

ATP and cancer immunosurveillance – Oliver Kepp, Lucillia Bezu, Takahiro Yamazaki, Francesco Di Virgilio, Mark J Smyth, Guido Kroemer, Lorenzo Galluzzi. https://www.embopress.org/doi/abs/10.15252/embj.2021108130

Regulation of Autophagy Enzymes by Nutrient Signaling – Karyn E. King, Truc T. Losier, Ryan C. Russell. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00020-7

The mTOR–Autophagy Axis and the Control of Metabolism – Nerea Deleyto-Seldas and Alejo Efeyan. https://www.frontiersin.org/articles/10.3389/fcell.2021.655731/full

Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer – Macus Hao-Ran Bao and Carmen Chak-Lui Wong. https://www.mdpi.com/2073-4409/10/7/1715

Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers – Juan C García-Cañaveras 1, Agustín Lahoz. https://www.mdpi.com/2072-6694/13/13/3230

Targeting Serine in Cancer: Is Two Better Than One? – Aitziber Buqué, Lorenzo Galluzzi, David C. Montrose. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00134-5

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma – Anna Han, Zachary T. Schug, Andrew E. Aplin. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00106-0

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids – Erica Pranzini, Elisa Pardella, Paolo Paoli, Sarah-Maria Fendt, Maria Letizia Taddei. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00046-7

Metabolic Plasticity of Neutrophils: Relevance to Pathogen Responses and Cancer – Thomas Rogers, Ralph J. DeBerardinis. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00099-6

Therapeutic Repurposing of Biguanides in Cancer – Hongyun Zhao, Kenneth D. Swanson, Bin Zheng. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00064-9

Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment – Anna M. Chiarella, Yun K. Ryu, Gulam A. Manji, Anil K. Rustgi. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00100-X

Immunometabolism: A ‘Hot’ Switch for ‘Cold’ Pediatric Solid Tumors – Lin Xiao, Harrison Yeung, Michelle Haber, Murray D. Norris, Klaartje Somers. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00103-5

Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity – Eileen White, Edmund C. Lattime, Jessie Yanxiang Guo. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00104-7

Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy – Wen-Hsuan Yang, Yijian Qiu, Olivia Stamatatos, Tobias Janowitz, Michael J. Lukey. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00083-2


Comments


How the amino acid leucine activates the key cell-growth regulator mTOR – Tibor Vellai. https://www.nature.com/articles/d41586-021-01943-7

Is glucose the scapegoat for tumor evasion? – Lydia N. Raines, Stanley Ching-Cheng Huang. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00327-5

Hunger brings down the tumor fort – Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00097-0

Oxidative phosphorylation system and cell culture media – Pilar Bayona-Bafaluy, Julio Montoya, Eduardo Ruiz-Pesini. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00095-7

2-HG modulates glioma macrophages via Trp metabolism – Marie Jo Halaby and Tracy L. McGaha. https://www.nature.com/articles/s43018-021-00231-7

Zebrafish as a New Model to Study the Crosstalk between Tumor and Host Metabolism – Emily Montal, Richard M. White. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00138-2

IDH-Mutant Brain Tumors Hit the Achilles’ Heel of Macrophages with R-2-Hydroxyglutarate – Xanthe A.M.H. van Dierendonck, Kyra E. de Goede, Jan Van den Bossche. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00133-3

 

 

Cancer immunometabolism – EMBO Workshop

29 November – 01 December 2021 | Sitges, Barcelona, Spain – Hybrid conference

We will issue full refunds in case of COVID-related travel restrictions, and you can also join us online.

Organized by Cristina Muñoz Pinedo, Jean-Ehrland Ricci and Eric Eldering

promoted-template

https://meetings.embo.org/event/21-cancer

 

MetaboList – June 2021


Glucose metabolism


KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition – Pranavi Koppula, Kellen Olszewski, Yilei Zhang, Lavanya Kondiparthi, Xiaoguang Liu, Guang Lei, Molina Das, Bingliang Fang, Masha V. Poyurovsky, Boyi Gan. https://www.cell.com/iscience/fulltext/S2589-0042(21)00617-9

PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer – Thu H. Truong, Elizabeth A. Benner, Kyla M. Hagen, Nuri A. Temiz, Carlos Perez Kerkvliet, Ying Wang, Emilio Cortes-Sanchez, Chieh-Hsiang Yang, Marygrac e C. Trousdell, Thomas Pengo, Katrin P. Guillen, Bryan E. Welm, Camila O. Dos Santos, Sucheta Telang, Carol A. Lange and Julie H. Ostrander. https://www.nature.com/articles/s41388-021-01871-w

Dual covalent inhibition of PKM and IMPDH targets metabolism in cutaneous metastatic melanoma – Marwa Zerhouni, Anthony R. Martin, Nathan Furstoss, Vincent S. Gutierrez, Emilie Jaune, Nedra Tekaya, Guillaume E. Beranger, Patricia Abbe, Claire Regazzetti, Hella Amdouni, Mohsine Driowya, Patrice Dubreuil, Frédéric Luciano, Arnaud Jacquel, Meri K. Tulic, Thomas Cluzeau, Brendan P. O’Hara, Issam Ben-Sahra, Thierry Passeron, Rachid Benhida, Guillaume Robert, Patrick Auberger and Stéphane Rocchi. https://cancerres.aacrjournals.org/content/early/2021/06/04/0008-5472.CAN-20-2114.long

The role of endoplasmic reticulum in in vivo cancer FDG kinetics – Sara Sommariva, Mara Scussolini, Vanessa Cossu, Cecilia Marini, Gianmario Sambuceti, Giacomo Caviglia, Michele Piana. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252422

Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma – Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara and Florian Muller. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00259-4


Lactate


Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas – Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch’ng, K. Mark Parnell, Nicolás M. Reinoso-Vizcaíno, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, and Micah A. Luftig. https://www.pnas.org/content/118/25/e2022495118.abstract

Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition – Catherine Vander Linden, Cyril Corbet, Estelle Bastien, Ruben Martherus, Céline Guilbaud, Laurenne Petit, Loris Wauthier, Axelle Loriot, Charles De Smet, Olivier Feron. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00551-9

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer – Jiang J, Huang D, Jiang Y, Hou J, Tian M, Li J, Sun L, Zhang Y, Zhang T, Li Z, Li Z, Tong S, Ma Y.. https://www.frontiersin.org/articles/10.3389/fonc.2021.647559/full


Amino acids


Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells – Alice Clare Newman, Mattia Falcone, Alejandro Huerta Uribe, Tong Zhang, Dimitris Athineos, Matthias Pietzke, Alexei Vazquez, Karen Blyth, Oliver David Kenneth Maddocks. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00214-8

SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells – Yingying Tong, Dong Guo, Shu-Hai Lin, Jiazhen Liang, Dianqiang Yang, Chunmin Ma, Fei Shao, Min Li, Qiujing Yu, Yuhui Jiang, Lei Li, Jing Fang, Rilei Yu, Zhimin Lu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00269-0

Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-14 amplification – Thanh H. Nguyen, Prasantha . Vemu, Gregory E. Hoy, Salah Boudjadi, Bishwanath Chatterjee, Jack F. Shern, Javed Khan, Wenyue Sun, and Frederic G. Barr. https://www.jci.org/articles/view/138022


Lipid metabolism


E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment – Francisco González-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O’Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela-Rey, Marta Palomo-Irigoyen, Beatriz Gómez-Santos, Diego Sáenz de Urturi, Maitane Núñez-García, Juan L. García-Rodríguez, Larraitz Fernández-Ares, Xabier Buqué, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C. Delgado, Naroa Goikoetxea-Usandizaga, Richard Lee, Sanjay Bhanot, Igotz Delgado, Maria J. Perugorria, Gaizka Errazti, Lorena Mosteiro, Sonia Gaztambide, Idoia Martinez de la Piscina, Paula Iruzubieta, Javier Crespo, Jesus M. Banales, Maria L. Martínez-Chantar, Luis Castaño, Ana M. Zubiaga and Patricia Aspichueta. https://cancerres.aacrjournals.org/content/81/11/2874

Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma – Daria Capece, Daniel D’Andrea, Federica Begalli, Laura Goracci, Laura Tornatore, James L. Alexander, Alessandra Di Veroli, Shi-Chi Leow, Thamil S. Vaiyapuri, James K. Ellis, Daniela Verzella, Jason Bennett, Luca Savino, Yue Ma, James S. McKenzie, Maria Luisa Doria, Sam E. Mason, Kern Rei Chng, Hector C. Keun, Gary Frost, Vinay Tergaonkar, Katarzyna Broniowska, Walter Stunkel, Zoltan Takats, James M. Kinross, Gabriele Cruciani, and Guido Franzoso. https://www.jci.org/articles/view/137845

Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability – Triana Amen, Daniel Kaganovich. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00596-9

Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development – Hidenori Ito, Ikuko Nakamae, Jun-ya Kato, and Noriko Yoneda-Kato. https://www.jci.org/articles/view/141529

Cancer-associated cells release citrate to support tumour metastatic progression – Konstantin Drexler, Katharina M Schmidt, Katrin Jordan, Marianne Federlin, Vladimir M Milenkovic, Gerhard Liebisch, Anna Artati, Christian Schmidl, Gregor Madej, Janina Tokarz, Alexander Cecil, Wolfgang Jagla, Silke Haerteis, Thiha Aung, Christine Wagner, Maria Kolodziejczyk, Stefanie Heinke, Evan H Stanton, Barbara Schwertner, Dania Riegel, Christian H Wetzel, Wolfgang Buchalla, Martin Proescholdt, Christoph A Klein, Mark Berneburg, Hans J Schlitt, Thomas Brabletz, Christine Ziegler, Eric K Parkinson, Andreas Gaumann, Edward K Geissler, Jerzy Adamski, Sebastian Haferkamp and Maria E Mycielska. https://www.life-science-alliance.org/content/4/6/e202000903.abstract


Nucleotides and NAD


NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma – Tanya Schild, Melanie R. McReynolds, Christie Shea, Vivien Low, Bethany E. Schaffer, John M. Asara, Elena Piskounova, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00597-0

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics – Veerle W. Daniels , Jason J. Zoeller, Nick van Gastel, Kelley E. McQueeney, Salma Parvin, Danielle S. Potter, Geoffrey G. Fell, Vinícius G. Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D. Bhola, Jennifer E. Endress, Isaac S. Harris, Emanuel Carrilho, Kristopher A. Sarosiek, David T. Scadden, Joan S. Brugge, Anthony Letai. https://stke.sciencemag.org/content/14/686/eabc7405

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy – Jian Chen, Risi Na, Chao Xiao, Xiao Wang, Yupeng Wang, Dongwang Yan, Guohe Song, Xueni Liu, Jiayi Chen, Huijun Lu, Chunyan Chen, Huamei Tang, Guohong Zhuang, Guangjian Fan and Zhihai Peng. https://www.nature.com/articles/s41388-021-01815-4

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma – Shunsuke Kunou, Kazuyuki Shimada, Mika Takai, Akihiko Sakamoto, Tomohiro Aoki, Tomoya Hikita, Yusuke Kagaya, Eisuke Iwamoto, Masashi Sanada, Satoko Shimada, Fumihiko Hayakawa, Chitose Oneyama and Hitoshi Kiyoi. https://www.nature.com/articles/s41388-021-01829-y


Mitochondria


ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis – Charles Ricordel, Laura Chaillot, Alice Blondel, Jérôme Archambeau, Florence Jouan, Audrey Mouche, Marie Tiercin, Agnès Burel, Hervé Lena, Benoît Desrues, Thierry Guillaudeux and Rémy Pedeux. https://www.nature.com/articles/s41388-021-01832-3

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex – Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao and Chenji Wang

https://www.nature.com/articles/s41419-021-03908-0


Starvation, nutrient sensing


Sugar phosphate activation of the stress sensor eIF2B – Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong and Carmela Sidrauski. https://www.nature.com/articles/s41467-021-23836-z

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase – Simon Klaessens, Vincent Stroobant, Delia Hoffmann, Mads Gyrd-Hansen, Luc Pilotte, Nathalie Vigneron, Etienne De Plaen, and Benoit J. Van den Eynde. https://www.pnas.org/content/118/23/e2022447118.abstract?etoc

TOR and MAP kinase pathways synergistically regulate autophagy in response to nutrient depletion in fission yeast – Cristina Corral-Ramos, Rubén Barrios, José Ayté and Elena Hidalgo. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1935522

Pharmacological preconditioning protects from ischemia/reperfusion‐induced apoptosis by modulating Bcl‐xL expression through a ROS‐dependent mechanism – Romain Rozier, Rachel Paul, Blandine Madji Hounoum, Elodie Villa, Rana Mhaidly, Johanna Chiche, Els Verhoeyen, Sandrine Marchetti, Ashaina Vandenberghe, Marc Raucoules, Michel Carles, Jean-Ehrland Ricci. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15675

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1 – Mengqi Li, Chen-Song Zhang, Jin-Wei Feng, Xiaoyan Wei, Cixiong Zhang, Changchuan Xie, Yaying Wu, Simon A. Hawley, Abdelmadjid Atrih, Douglas J. Lamont, Zhichao Wang, Hai-Long Piao, D. Grahame Hardie and Sheng-Cai Lin. https://www.nature.com/articles/s41422-020-00456-8


mTOR


Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling – Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini and Alejo Efeyan. https://www.nature.com/articles/s41467-021-23857-8

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals – Jun Jin , Chulwoo Kim, Qiong Xia, Timothy M. Gould, Wenqiang Cao, Huimin Zhang, Xuanying Li, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Cornelia M. Weyand, Jorg J. Goronzy. https://immunology.sciencemag.org/content/6/60/eabg0791

ArfGAP1 inhibits mTORC1 lysosomal localization and activation – Delong Meng, Qianmei Yang, Chase H Melick, Brenden C Park, Ting-Sung Hsieh, Adna Curukovic, Mi-Hyeon Jeong, Junmei Zhang, Nicholas G James, Jenna L Jewell. https://www.embopress.org/doi/full/10.15252/embj.2020106412

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia – Zengzhang Zheng, Wanyan Deng, Yang Bai, Rui Miao, Shenglin Mei, Zhibin Zhang, Youdong Pan, Yi Wang, Rui Min, Fan Deng, Zeyu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, Judy Lieberman, Xing Liu. https://science.sciencemag.org/content/372/6549/eabg0269

Vps34 and TOR Kinases Coordinate HAC1 mRNA Translation in the Presence or Absence of Ire1-Dependent Splicing – Jagadeesh Kumar Uppala, Sankhajit Bhattacharjee, and Madhusudan Dey. https://doi.org/10.1128/MCB.00662-20

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1 – Raphael Böhm, Stefan Imseng, Roman P. Jakob, Michael N. Hall, Timm Maier, Sebastian Hiller. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00226-4

TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose – Yusuke Toyoda ; Saeko Soejima; Fumie Masuda; Shigeaki Saitoh. https://journals.biologists.com/jcs/article-abstract/134/10/jcs257485/268339


Hypoxia and HIFs


Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination–deficient cancer models – Manal Mehibel, Yu Xu, Caiyun G. Li, Eui Jung Moon, Kaushik N. Thakkar, Anh N. Diep, Ryan K. Kim, Joshua D. Bloomstein, Yiren Xiao, Julien Bacal, Joshua C. Saldivar, Quynh-Thu Le, Karlene A. Cimprich, Erinn B. Rankin, and Amato J. Giaccia. https://www.jci.org/articles/view/146256

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron – Rashi Singhal, Sreedhar R. Mitta, Nupur K. Das, Samuel A. Kerk, Peter Sajjakulnukit, Sumeet Solanki, Anthony Andren, Roshan Kumar, Kenneth P. Olive, Ruma Banerjee, Costas A. Lyssiotis, and Yatrik M. Shah. https://www.jci.org/articles/view/143691

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes – Travis Peng, Shin-Yi Du, Myoungsun Son, and Betty Diamond. https://www.pnas.org/content/118/26/e2106017118.abstract?etoc


Cancer Immunometabolism


Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD – Hsin-Fang Tu, Chun-Jung Ko, Ching-Tai Lee, Cheng-Fan Lee, Shao-Wei Lan, Hsin-Hsien Lin, Hsin-Ying Lin, Chia-Chi Ku, Der-Yen Lee, I-Chun Chen, Ya-Hui Chuang, Francisco Del Caño-Ochoa, Santiago Ramón-Maiques, Chao-Chi Ho, Ming-Shyue Lee and Geen-Dong Chang. https://cancerres.aacrjournals.org/content/81/12/3270

Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors – Lin Wang, Luz M. Londono, Jessica Cowell, Ozge Saatci, Mertkaya Aras, Pelin G. Ersan, Sara Serra, Hong Pei, Renee Clift, Qiping Zhao, Kim B. Phan, Lei Huang, Michael J. LaBarre, Xiaoming Li, H. Michael Shepard, Silvia Deaglio, Joel Linden, Christopher D. Thanos, Ozgur Sahin and Caglar Cekic. https://cancerres.aacrjournals.org/content/81/12/3319

Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function – Sam Sheppard, Endi K. Santosa, Colleen M. Lau, Sara Violante, Paolo Giovanelli, Hyunu Kim, Justin R. Cross, Ming O. Li, Joseph C. Sun. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00559-3

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment – Sophie M. Poznanski, Kanwaldeep Singh, Tyrah M. Ritchie, Jennifer A. Aguiar, Isabella Y. Fan, Ana L. Portillo, Eduardo A. Rojas, Fatemeh Vahedi, Abdullah El-Sayes, Sansi Xing, Martin Butcher, Yu Lu, Andrew C. Doxey, Jonathan D. Schertzer, Hal W. Hirte, Ali A. Ashkar. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00130-3

Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade – Xiaoming Dai, Xia Bu, Yang Gao, Jianping Guo, Jia Hu, Cong Jiang, Zhao Zhang, Kexin Xu, Jinzhi Duan, Shaohui He, Jinfang Zhang, Lixin Wan, Tianjie Liu, Xiaobo Zhou, Mien-Chie Hung, Gordon J. Freeman, Wenyi Wei. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00232-X


Cachexia


Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia – Joseph E. Rupert; Ashok Narasimhan ; Daenique H.A. Jengelley; Yanlin Jiang; Jianguo Liu; Ernie Au; Libbie M. Silverman ; George Sandusky; Andrea Bonetto; Sha Cao; Xiaoyu Lu; Thomas M. O’Connell ; Yunlong Liu; Leonidas G. Koniaris; Teresa A. Zimmers. https://rupress.org/jem/article/218/6/e20190450/211985

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models – Mengyuan Niu, Li Li, Zhonglan Su, Lulu Wei, Wenyuan Pu, Chen Zhao, Yibing Ding, Junaid Wazir, Wangsen Cao, Shiyu Song, Qian Gao and Hongwei Wang. https://www.nature.com/articles/s41419-021-03932-0


Miscellaneous


In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor – Jacob P. Keller, Jonathan S. Marvin, Haluk Lacin, William C. Lemon, Jamien Shea, Soomin Kim, Richard T. Lee, Minoru Koyama, Philipp J. Keller, Loren L. Looger. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00656-2

Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma – Jianhua Cao, Benjamin Balluff, Martijn Arts, Ludwig J. Dubois, Luc J. C. van Loon, Tilman M. Hackeng, Hans M. H. van Eijk, Gert Eijkel, Lara R. Heij, Zita Soons, Steven W. M. Olde Damink and Ron M. A. Heeren. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00262-9

Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation – Jiao-Jiao Zhang, Ting-Ting Fan, Yun-Zi Mao, Jun-Li Hou, Meng Wang, Min Zhang, Yan Lin, Lei Zhang, Guo-Quan Yan, Yan-Peng An, Jun Yao, Cheng Zhang, Peng-Cheng Lin, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu and Shi-Min Zhao. https://www.nature.com/articles/s42255-021-00405-8

The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study – Huaili Jiang, Lei Zhou, Qiangsheng He, Kanglun Jiang, Jinqiu Yuan and Xinsheng Huang. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00261-w


Reviews


Targeting the Metabolic Adaptation of Metastatic Cancer – Josep Tarragó-Celada and Marta Cascante. https://www.mdpi.com/2072-6694/13/7/1641

Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure – Kosaku Uyeda. https://www.annualreviews.org/doi/10.1146/annurev-biochem-070820-125228

Assays for Determination of Cellular and Mitochondrial NAD+ and NADH Content – Yue Yang, Anthony A. Sauve. https://link.springer.com/protocol/10.1007%2F978-1-0716-1433-4_15

Mitochondrial DNA variation and cancer – Piotr K. Kopinski, Larry N. Singh, Shiping Zhang, Marie T. Lott and Douglas C. Wallace. https://www.nature.com/articles/s41568-021-00358-w

Role of NAD+ in regulating cellular and metabolic signaling pathways – Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris, Ravinder Reddy, Zoltan Patay, Joseph Baur, Puneet Bagga. https://www.sciencedirect.com/science/article/pii/S2212877821000351

Lipid droplets and the host–pathogen dynamic: FATal attraction? – Marta Bosch, Matthew J. Sweet, Robert G. Parton, Albert Pol. https://rupress.org/jcb/article-abstract/220/8/e202104005/212436

The role of polyamines in gastric cancer – Kara M. McNamara, Alain P. Gobert and Keith T. Wilson. https://www.nature.com/articles/s41388-021-01862-x


Comments


Can tumor cells take it all away? – Anna Kohl, Kung-Chi Kao, Ping-Chih Ho. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00227-8

Creatine promotes metastatic dissemination – Damien Lagarde, Lawrence Kazak. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00229-1

MetaboList – May 2021


Miscellaneous


Mammary epithelial cells have lineage-rooted metabolic identities – Mathepan Jeya Mahendralingam, Hyeyeon Kim, Curtis William McCloskey, Kazeera Aliar, Alison Elisabeth Casey, Pirashaanthy Tharmapalan, Davide Pellacani, Vladimir Ignatchenko, Mar Garcia-Valero, Luis Palomero, Ankit Sinha, Jennifer Cruickshank, Ronak Shetty, Ravi N. Vellanki, Marianne Koritzinsky, Vid Stambolic, Mina Alam, Aaron David Schimmer, Hal Kenneth Berman, Connie J. Eaves, Miquel Angel Pujana, Thomas Kislinger and Rama Khokha. https://www.nature.com/articles/s42255-021-00388-6

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4 – Pallavi Jain, Anna Dvorkin-Gheva, Erik Mollen, Lucie Malbeteau, Michael Xie, Fatima Jessa, Piriththiv  Dhavarasa, Stephen Chung, Kevin R. Brown, Gun Ho Jang, Parth Vora, Faiyaz Notta, Jason Moffat, David  Hedley, Paul C. Boutros, Bradly G. Wouters, Marianne Koritzinsky. https://advances.sciencemag.org/content/7/19/eabf7114

Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells – Song Chen, Caroline Chandra Tjin, Xiang Gao, Yi Xue, Haoyan Jiao, Ruilin Zhang, Mengnan Wu, Zunyu He, Jonathan Ellman, and Ya Ha. https://www.pnas.org/content/118/21/e2002486118.abstract?etoc

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non–Small Cell Lung Cancer – Michael Skwarski, Daniel R. McGowan, Elizabeth Belcher, Francesco Di Chiara, Dionisios Stavroulias, Mark McCole, Jennifer L. Derham, Kwun-Ye Chu, Eugene Teoh, Jagat Chauhan, Dawn O’Reilly, Benjamin H.L. Harris, Philip S. Macklin, Joshua A. Bull, Marcus Green, Gonzalo Rodriguez-Berriguete, Remko Prevo, Lisa K. Folkes, Leticia Campo, Petra Ferencz, Paula L. Croal, Helen Flight, Cathy Qi, Jane Holmes, James P.B. O’Connor, Fergus V. Gleeson, W. Gillies McKenna, Adrian L. Harris, Daniel Bulte, Francesca M. Buffa, Ruth E. Macpherson and Geoff S. Higgins. https://clincancerres.aacrjournals.org/content/27/9/2459

Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors – Antje Wick, Oliver Bähr, Martin Schuler, Kristoffer Rohrberg, Sant P. Chawla, Filip Janku, David Schiff, Volker Heinemann, Yoshitaka Narita, Heinz-Josef Lenz, Masafumi Ikeda, Yuichi Ando, Wolfgang Wick, Joachim P. Steinbach, Michael C. Burger, Katharina Wenger, Ulrik Lassen, Kamalesh K. Sankhala, Cristiana Roggia, Isabelle Genvresse, Catya Munhoz, Christine Rentzsch, Susanne Reschke, Simon Langer, Markus Wagner, Stefan Kaulfuss, Charles Cai, Eleni Lagkadinou, Michael Jeffers, Carol Peña and Ghazaleh Tabatabai. https://clincancerres.aacrjournals.org/content/27/10/2723


Amino acid metabolism


Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia – Tra Ly Nguyen, Marie‐Julie Nokin, Silvia Terés, Mercedes Tomé, Clément Bodineau, Oriane Galmar, Jean‐Max Pasquet, Benoit Rousseau, Sebastian van Liempd, Juan Manuel Falcon‐Perez, Elodie Richard, Elodie Muzotte, Hamid‐Reza Rezvani, Muriel Priault, Marion Bouchecareilh, Isabelle Redonnet‐Vernhet, Julien Calvo, Benjamin Uzan, Françoise Pflumio, Patricia Fuentes, Maria L. Toribio, Abdel‐Majid Khatib, Pierre Soubeyran, Piedad del Socorro Murdoch, Raúl V. Durán. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12877

Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness – Yollanda E. Moreira Franco, Maria Jose Alves, Miyuki Uno, Isabele Fattori Moretti, Marina Trombetta-Lima, Suzana de Siqueira Santos, Ancely Ferreira dos Santos, Gabriel Santos Arini, Mauricio S. Baptista, Antonio Marcondes Lerario, Sueli Mieko Oba-Shinjo and Suely Kazue Nagahashi Marie. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00255-8

Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil – David C. Montrose, Suchandrima Saha, Miguel Foronda, Erin M. McNally, Justin Chen, Xi Kathy Zhou, Taehoon Ha, Jan Krumsiek, Mustafa Buyukozkan, Akanksha Verma, Olivier Elemento, Rhonda K. Yantiss, Qiuying Chen, Steven S. Gross, Lorenzo Galluzzi, Lukas E. Dow and Andrew J. Dannenberg. https://cancerres.aacrjournals.org/content/81/9/2275


Lipid metabolism


Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation – Wei Tan, Pei Jiang, Wanjun Zhang, Zhaohua Hu, Shaofeng Lin, Lulu Chen, Yingge Li, Changmin Peng, Zhuqing Li, Aihua Sun, Yali Chen, Wenge Zhu, Yu Xue, Yi Yao, Xiangpan Li, Qibin Song, Fuchu He, Weijie Qin, Huadong Pei. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00095-2

Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching – Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Cunjie Zhang, Emily Branchard, Mohamad Elbaz, David W. Cescon, Richard R. Drake, James W. Dennis and Linda Z. Penn. https://cancerres.aacrjournals.org/content/81/10/2625

HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma – Jiajun Huang, Xiaoyu Zhao, Xiang Li, Jiwei Peng, Weihao Yang, Shengli Mi. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001197


Nucleotides


DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer – Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan. https://www.nature.com/articles/s41586-021-03539-7

IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex – Alexander J Valvezan, Molly C McNamara, Spencer K Miller, Margaret E Torrence, John M Asara, Elizabeth P Henske, Brendan D Manning. https://insight.jci.org/articles/view/135071

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity – Hans-Georg Sprenger, Thomas MacVicar, Amir Bahat, Kai Uwe Fiedler, Steffen Hermans, Denise Ehrentraut, Katharina Ried, Dusanka Milenkovic, Nina Bonekamp, Nils-Göran Larsson, Hendrik Nolte, Patrick Giavalisco and Thomas Langer. https://www.nature.com/articles/s42255-021-00385-9


Mitochondria


Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS – Alexis A. Jourdain, Bridget E. Begg, Eran Mick, Hardik Shah, Sarah E. Calvo, Owen S. Skinner, Rohit Sharma, Steven M. Blue, Gene W. Yeo, Christopher B. Burge, Vamsi K. Mootha. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00143-X

Physiological concentrations of cyanide stimulate mitochondrial Complex IV and enhance cellular bioenergetics – Elisa B. Randi, Karim Zuhra, Laszlo Pecze, Theodora Panagaki, and Csaba Szabo. https://www.pnas.org/content/118/20/e2026245118.abstract?etoc

Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells – Donna L. Nile, Colin Rae, David J. Walker, Joe Canning Waddington, Isabel Vincent, Karl Burgess, Mark N. Gaze, Robert J. Mairs and Anthony J. Chalmers. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00258-5

TNF-α differentially modulates subunit levels of respiratory electron transport complexes of ER/PR +ve/−ve breast cancer cells to regulate mitochondrial complex activity and tumorigenic potential – Anjali Shinde, Hyeryeon Jung, Hayun Lee, Kritarth Singh, Milton Roy, Dhruv Gohel, Han Byeol Kim, Minal Mane, Hitesh Vasiyani, Fatema Currim, Yu Ri Seo, Seojin Yang, Ara Cho, Eugene C. Yi and Rajesh Singh. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00254-9

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis – Yi-Ping Wang, Azeem Sharda, Shuang-Nian Xu, Nick van Gastel, Cheuk Him Man, Una Choi, Wei Zhong Leong, Xi Li, David T. Scadden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00110-8


Heme and iron


Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy – Cristian Sandoval-Acuña, Natalia Torrealba, Veronika Tomkova, Sukanya B. Jadhav, Kristyna Blazkova, Ladislav Merta, Sandra Lettlova, Miroslava K. Adamcová, Daniel Rosel, Jan Brábek, Jiri Neuzil, Jan Stursa, Lukas Werner and Jaroslav Truksa. https://cancerres.aacrjournals.org/content/81/9/2289

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron – Rashi Singhal, Sreedhar R. Mitta, Nupur K. Das, Samuel A. Kerk, Peter Sajjakulnukit, Sumeet Solanki, Anthony Andren, Roshan Kumar, Kenneth P. Olive, Ruma Banerjee, Costas A. Lyssiotis, Yatrik M. Shah. https://www.jci.org/articles/view/143691

Heme catabolism by tumor-associated macrophages controls metastasis formation – Francesca Maria Consonni, Augusto Bleve, Maria Grazia Totaro, Mariangela Storto, Paolo Kunderfranco, Alberto Termanini, Fabio Pasqualini, Chiara Alì, Chiara Pandolfo, Francesco Sgambelluri, Giulia Grazia, Mario Santinami, Andrea Maurichi, Massimo Milione, Marco Erreni, Andrea Doni, Marco Fabbri, Laura Gribaldo, Eliana Rulli, Miguel Parreira Soares, Valter Torri, Roberta Mortarini, Andrea Anichini and Antonio Sica. https://www.nature.com/articles/s41590-021-00921-5

BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis – Mónica Vara-Pérez, Matteo Rossi, Chris Van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D Garg, Corentin Schepkens, Francesca M Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes V Swinnen, Jean Marie Colet, Joost J van den Oord, Sarah-Maria Fendt, Massimiliano Mazzone, Patrizia Agostinis. https://www.embopress.org/doi/full/10.15252/embj.2020106214


Glucose metabolism


Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation – Jianneng Li , Michael Berk, Mohammad Alyamani, Navin Sabharwal, Christopher Goins, Joseph Alvarado, Mehdi Baratchian, Ziqi Zhu, Shaun Stauffer, Eric A. Klein, Nima Sharifi. https://stm.sciencemag.org/content/13/595/eabe8226

MIG‐6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple‐negative breast cancer – Jiabei He, Chien‐Feng Li, Hong‐Jen Lee, Dong‐Hui Shin, Yi‐Jye Chern, Bruno Pereira De Carvalho, Chia‐Hsin Chan. https://www.embopress.org/doi/full/10.15252/embr.202050781


Starvation / metabolic stress


Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR – Sophie Kaspar, Christian Oertlin, Karolina Szczepanowska, Alexandra Kukat, Katharina Senft, Christina Lucas, Susanne Brodesser, Maria Hatzoglou, Ola Larsson, Ivan Topisirovic, Aleksandra Trifunovic. https://advances.sciencemag.org/content/7/22/eabf0971

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis – Hua Su, Fei Yang, Rao Fu, Xin Li, Randall French, Evangeline Mose, Xiaohong Pu, Brittney Trinh, Avi Kumar, Junlai Liu, Laura Antonucci, Jelena Todoric, Yuan Liu, Yinling Hu, Maria T. Diaz-Meco, Jorge Moscat, Christian M. Metallo, Andrew M. Lowy, Beicheng Sun, Michael Karin. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00118-5

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification – Shi Yu, Jack Green, Rose Wellens, Gloria Lopez‐Castejon, David Brough. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15619

Glucose deprivation induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma – Jane H.C. Loong, Tin-Lok Wong, Man Tong, Rakesh Sharma, Lei Zhou, Kai-Yu Ng, Hua-Jian Yu, Chi Han Li, Kwan Man, Chung-Mau Lo, Xin-Yuan Guan, Terence K. Lee, Jing-Ping Yun, Stephanie Kwai Yee Ma. https://www.jci.org/articles/view/143377


mTOR


mTORC1 promotes cell growth via m6A-dependent mRNA degradation – Sungyun Cho, Gina Lee, Brian F. Pickering, Cholsoon Jang, Jin H. Park, Long He, Lavina Mathur, Seung-Soo Kim, Sunhee Jung, Hong-Wen Tang, Sebastien Monette, Joshua D. Rabinowitz, Norbert Perrimon, Samie R. Jaffrey, John Blenis. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00178-7

mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis – Elodie Villa, Umakant Sahu, Brendan P. O’Hara, Eunus S. Ali, Kathryn A. Helmin, John M. Asara, Peng Gao, Benjamin D. Singer, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00177-5


Cancer Immunometabolism


CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability – Xingzhe Ma, Liuling Xiao, Lintao Liu, Lingqun Ye, Pan Su, Enguang Bi, Qiang Wang, Maojie Yang, Jianfei Qian, Qing Yi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00071-1

Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation – Nicholas T. Crump, Andreas V. Hadjinicolaou, Meng Xia, John Walsby-Tickle, Uzi Gileadi, Ji-Li Chen, Mashiko Setshedi, Lars R. Olsen, I-Jun Lau, Laura Godfrey, Lynn Quek, Zhanru Yu, Erica Ballabio, Mike B. Barnkob, Giorgio Napolitani, Mariolina Salio, Hashem Koohy, Benedikt M. Kessler, Stephen Taylor, Paresh Vyas, James S.O. McCullagh, Thomas A. Milne, Vincenzo Cerundolo. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00435-6

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy – Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E. Dale Abel, David G. Kirsch, Jeffrey C. Rathmell, Marie-Catherine Vozenin and Etienne Meylan. https://cancerres.aacrjournals.org/content/81/9/2345


Methods


High-resolution spatiotemporal pHe and pO2 imaging in head and neck and oesophageal carcinoma cells – Alexandra Blancke Soares, Robert Meier, Gregor Liebsch, Sabina Schwenk-Zieger, Martin E. Kirmaier, Sebastian Theurich, Magdalena Widmann, Martin Canis, Olivier Gires and Frank Haubner. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00257-6

Quantum monitoring of cellular metabolic activities in single mitochondria – Nie, A. C. Nusantara, V. G. Damle, R. Sharmin, E. P. P. Evans, S. R. Hemelaar, K. J. van der Laan, R. Li, F. P. Perona Martinez, T. Vedelaar, M. Chipaux, R. Schirhagl. https://advances.sciencemag.org/content/7/21/eabf0573


Reviews


Lipid metabolism in cancer: New perspectives and emerging mechanisms – Lindsay A. Broadfield, Antonino Alejandro Pane, Ali Talebi, Johannes V. Swinnen, Sarah-Maria Fendt. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00322-1

Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response – Yarden Ariav, James H Ch’ng, Heather R. Christofk, Noga Ron-Harel, Ayelet Erez. https://advances.sciencemag.org/content/7/21/eabg6165

The functional roles of TCA cycle metabolites in cancer – Joseph Eniafe and Shuai Jiang. https://www.nature.com/articles/s41388-020-01639-8

Autophagy in metabolism and quality control: opposing, complementary or interlinked functions? – Vojo Deretic and Guido Kroemer. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1933742

DHODH and cancer: promising prospects to be explored – Yue Zhou, Lei Tao, Xia Zhou, Zeping Zuo, Jin Gong, Xiaocong Liu, Yang Zhou, Chunqi Liu, Na Sang, Huan Liu, Jiao Zou, Kun Gou, Xiaowei Yang and Yinglan Zhao. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00250-z

Targeting the Mevalonate Pathway in Cancer – Dennis Juarez and David A. Fruman. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30309-5

MicroRNA-mediated regulation of glucose and lipid metabolism – Pamela Agbu and Richard W. Carthew. https://www.nature.com/articles/s41580-021-00354-w

The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress – Stephen E. Girardin, Camille Cuziol, Dana J. Philpott, Damien Arnoult. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15553

Pyruvate carboxylase and cancer progression – Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt and Dorothy Teegarden. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00256-7

Open questions on the mitochondrial unfolded protein response – Friederike‐Nora Vögtle. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15569

Metabolic Codependencies in the Tumor Microenvironment – Prasenjit Dey, Alec C. Kimmelman and Ronald A. DePinho. https://cancerdiscovery.aacrjournals.org/content/11/5/1067

Evolving concepts in NAD+ metabolism – Claudia C.S. Chini, Julianna D. Zeidler, Sonu Kashyap, Gina Warner, Eduardo Nunes Chini. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00169-8

Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment? – Megan Jessica McNamee, David Michod and Maria Victoria Niklison-Chirou. https://www.nature.com/articles/s41420-021-00474-4


Comments


Immunotherapy breaches low-sugar dieting of tumor Treg cells – Clarissa Campbell, Alexander Y. Rudensky. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00176-5

More writing: mTORC1 promotes m6A mRNA methylation – Sunil Shetty, Michael N. Hall. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00325-7

When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS – Aaron A. Hoskins and Timothy W. Rhoads. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00294-X

NRF2 activates macropinocytosis upon autophagy inhibition – Gourish Mondal and Jayanta Debnath. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00169-0

Autophagy is critical for cysteine metabolism in pancreatic cancer through regulation of SLC7A11 – Subhadip Mukhopadhyay and Alec C. Kimmelman. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1922984

A mitochondrial gatekeeper that helps cells escape death by ferroptosis – Javier Garcia-Bermudez and Kıvanç Birsoy. https://www.nature.com/articles/d41586-021-01203-8

Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction – Yuyang Liu and Kıvanç Birsoy. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00081-9

Breast cancer has a new metabolic Achilles’ heel – Tatiana Alfonso-Pérez, Gabriel Baonza and Fernando Martin-Belmonte. https://www.nature.com/articles/s42255-021-00394-8

Distinct nutrient use in tumors – John F. Foley. https://stke.sciencemag.org/content/14/683/eabj4738

Anti-CTLA4 Perturbs Treg-Based Immunosuppression in Glycolysis-Low Tumorshttps://cancerdiscovery.aacrjournals.org/content/11/5/1003.2

Autophagy-Deficient Pancreatic Cancer Cells Depend on Macropinocytosishttps://cancerdiscovery.aacrjournals.org/content/11/5/OF28

MetaboList – April 2021


Cancer Immunometabolism


Cell-programmed nutrient partitioning in the tumour microenvironment – Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson, Ayaka Sugiura, Allison S. Cohen, Ahmed Ali, Brian T. Do, Alexander Muir, Caroline A. Lewis, Rachel A. Hongo, Kirsten L. Young, Rachel E. Brown, Vera M. Todd, Tessa Huffstater, Abin Abraham, Richard T. O’Neil, Matthew H. Wilson, Fuxue Xin, M. Noor Tantawy, W. David Merryman, Rachelle W. Johnson, Christopher S. Williams, Emily F. Mason, Frank M. Mason, Katherine E. Beckermann, Matthew G. Vander Heiden, H. Charles Manning, Jeffrey C. Rathmell and W. Kimryn Rathmell. https://www.nature.com/articles/s41586-021-03442-1

Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity – Yiwen Zhang, Hongrong Hu, Weiwei Liu,Shu-Mei Yan3, Yuzhuang Li, Likai Tan, Yingshi Chen, Jun Liu, Zhilin Peng, Yaochang Yuan, Wenjing Huang, Fei Yu, Xin He, Bo Li, Hui Zhang. https://jitc.bmj.com/content/9/4/e002137


Glucose metabolism


The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts – Junjie Gu, Xuechun Li, Lin Zhao, Ying Yang, Chunling Xue, Yang Gao, Jing Li, Qin Han, Zhao Sun, Chunmei Bai and Robert Chunhua Zhao. https://www.nature.com/articles/s41419-021-03579-x

BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells – Calder W. Reinsborough, Hélène Ipas, Nathan S. Abell, Ellen B. Gouws, J. Paige Williams, Marvin Mercado, Carla Van Den Berg and Blerta Xhemalçe. https://www.nature.com/articles/s41388-021-01702-y

Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response – Hayato Irokawa; Satoshi Numasaki; Shin Kato; Kenta Iwai; Atsushi Inose-Maruyama; Takumi Ohdate; Gi-Wook Hwang; Takashi Toyama; Toshihiko Watanabe; Shusuke Kuge. https://portlandpress.com/biochemj/article-abstract/478/7/1453/228124

DOWN REGULATION OF LACTATE DEHYDROGENASE INITIATES APOPTOSIS IN HELA AND MCF-7 CANCER CELLS THROUGH INCREASED VOLTAGE-DEPENDENT ANION CHANNEL PROTEIN AND INHIBITION OF BCL2 – Suhail Al-Salam, Karthishwaran Kandhan,  and  Manjusha Sudhadevi. https://www.oncotarget.com/article/27950/text/

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation – Anxo Martínez-Ordoñez, Samuel Seoane, Leandro Avila, Noemi Eiro, Manuel Macía, Efigenia Arias, Fabio Pereira, Tomas García-Caballero, Noemi Gómez-Lado, Pablo Aguiar, Francisco Vizoso and Román Perez-Fernandez. https://www.nature.com/articles/s41388-021-01740-6

The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells – Wenwen Gao, Mengqiu Huang, Xi Chen, Jianping Chen, Zhiwei Zou, Linlin Li, Kaiyuan Ji, Zhirui Nie, Bingsheng Yang, Zibo Wei, Pengfei Xu, Junshuang Jia, Qianbing Zhang, Hongfen Shen, Qianli Wang, Keyi Li, Lingqun Zhu, Meng Wang, Shuangyan Ye, Sisi Zeng, Ying Lin, Zhili Rong, Yang Xu, Peng Zhu, Hui Zhang, Bingtao Hao and Qiuzhen Liu. https://www.nature.com/articles/s41419-021-03681-0

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation – Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, and Ni Tang. https://www.jci.org/articles/view/144703

HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness – Lei Bi, Yidan Ren, Maoxiao Feng, Peng Meng, Qin Wang, Weiping Chen, Qinlian Jiao, Yuli Wang, Lutao Du, Fuqiong Zhou, Yucui Jiang, Feiyan Chen, Chuanxin Wang, Bo Tang and Yunshan Wang. https://cancerres.aacrjournals.org/content/81/8/2015


Amino acids and glycosamines


Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells – Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen and Hsing-Jien Kung. https://www.nature.com/articles/s41467-021-22652-9

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 – Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann and Martin S. Denzel. https://www.nature.com/articles/s41467-021-22320-y


Lipid metabolism


Fatty acid synthesis is required for breast cancer brain metastasis – Gino B. Ferraro, Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott, Divya Bezwada, Landry Blanc, Brendan Prideaux, Xin Jin, Jessica M. Possada, Jiang Chen, Christopher R. Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy X. Chen, Kamila Naxerova, Christopher Ng, Anna M. Westermark, Mark Duquette, Sylvie Roberge, Neal I. Lindeman, Costas A. Lyssiotis, Jens Nielsen, David E. Housman, Dan G. Duda, Elena Brachtel, Todd R. Golub, Lewis C. Cantley, John M. Asara, Shawn M. Davidson, Dai Fukumura, Véronique A. Dartois, Clary B. Clish, Rakesh K. Jain and Matthew G. Vander Heiden. https://www.nature.com/articles/s43018-021-00183-y

Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis – Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G. P. Grünewald, Adrian Liston, Chantal Mathieu, Christophe M. Deroose, Johannes V. Swinnen, Diether Lambrechts, Diego di Bernardo, Shinya Kuroda, Katrien De Bock and Sarah-Maria Fendt. https://cancerres.aacrjournals.org/content/early/2021/03/04/0008-5472.CAN-20-1954

Down-regulation of SLC25A20 promotes hepatocellular carcinoma growth and metastasis through suppression of fatty-acid oxidation – Peng Yuan, Jiao Mu, Zijun Wang, Shuaijun Ma, Xiuwei Da, Jian Song, Hongxin Zhang, Le Yang, Jibin Li and Jingyue Yang. https://www.nature.com/articles/s41419-021-03648-1


Nucleotides and NAD(P)


Mitochondrial NADP+ is essential for proline biosynthesis during cell growth – Diem H. Tran, Rushendhiran Kesavan, Halie Rion, Mona Hoseini Soflaee, Ashley Solmonson, Divya Bezwada, Hieu S. Vu, Feng Cai, John A. Phillips III, Ralph J. DeBerardinis and Gerta Hoxhaj. https://www.nature.com/articles/s42255-021-00374-y

Mitochondrial NADP(H) generation is essential for proline biosynthesis – Jiajun Zhu, Simon Schwörer, Mirela Berisa, Yeon Ju Kyung,Keun Woo Ryu, Junmei Yi, Xuejun Jiang, Justin R. Cross, Craig B. Thompson. https://science.sciencemag.org/content/early/2021/04/21/science.abd5491

Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer – Craig Davison, Roisin Morelli, Catherine Knowlson, Melanie McKechnie, Robbie Carson, Xanthi Stachtea, Kylie A. McLaughlin, Vivien E. Prise, Kienan Savage, Richard H. Wilson, Karl A. Mulligan, Peter M. Wilson, Robert D. Ladner and Melissa J. LaBonte. https://www.nature.com/articles/s41523-021-00245-5


Mitochondria


PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer – Laura C. A. Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian MacKay, David Sumpton, Owen J. Sansom, Hing Y. Leung and Imran Ahmad. https://www.nature.com/articles/s41388-021-01707-7

Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth – Denise Sighel, Michela Notarangelo, Shintaro Aibara, Angela Re, Gianluca Ricci, Marianna Guida, Alessia Soldano, Valentina Adami, Chiara Ambrosini, Francesca Broso, Emanuele Filiberto Rosatti, Sara Longhi, Mariachiara Buccarelli, Quintino G. D’Alessandris, Stefano Giannetti, Simone Pacioni, Lucia Ricci-Vitiani, Joanna Rorbach, Roberto Pallini, Sandrine Roulland, Alexey Amunts, Ines Mancini, Angelika Modelska, Alessandro Quattrone. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00338-7

Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria – Marshall L. Deline, Martin Grashei, Frits H.A. van Heijster, Franz Schilling, Joshua Straub, Tobias Fromme. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000426

Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly – Bennett CF, O’Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P.. https://www.nature.com/articles/s41589-021-00772-z

Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis – Maria E. Solesio, Lihan Xie, Brendan McIntyre, Mathew Ellenberger, Erna Mitaishvili, Siddharth Bhadra-Lobo, Lisa F. Bettcher, Jason N. Bazil, Daniel Raftery, Ursula Jakob, Evgeny V. Pavlov. https://portlandpress.com/biochemj/article-abstract/478/8/1631/228286


Starvation / nutrient sensing


Kog1/Raptor mediates metabolic rewiring during nutrient limitation by controlling SNF1/AMPK activity – Zeenat Rashida , Rajalakshmi Srinivasan, Meghana Cyanam, Sunil Laxman. https://advances.sciencemag.org/content/7/16/eabe5544

THOC4 regulates energy homeostasis by stabilizing TFEB mRNA during prolonged starvation – Toshiharu Fujita, Sayaka Kubo, Tatsuya Shioda, Ayaka Tokumura, SatoshiMinami, Megumi Tsuchiya, Yoshitaka Isaka, Hidesato Ogawa, Maho Hamasaki, Li Yu, Tamotsu Yoshimori and Shuhei Nakamura. http://jcs.biologists.org/content/134/6/jcs248203?etoc

Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation – Sulhee Kim, Ina Yoon, Jonghyeon Son, Junga Park, Kibum Kim, Ji-Ho Lee, Sam-Yong Park, Beom Sik Kang, Jung Min Han, Kwang Yeon Hwang, Sunghoon Kim. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00345-4

Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis – Guang Zhang, Yang Yang, Hao Hu, Kaiyue Liu, Bingyan Li, Yu Zhu, Zhongyu Wang, Qingfa Wu and Yide Mei. https://www.nature.com/articles/s41388-021-01749-x

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy – Chien-Min Hung , Portia S. Lombardo, Nazma Malik, Sonja N. Brun, Kristina Hellberg, Jeanine L. Van Nostrand, Daniel Garcia, Joshua Baumgart, Ken Diffenderfer, John M. Asara, Reuben J. Shaw. https://advances.sciencemag.org/content/7/15/eabg4544


Miscellaneous


The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer – Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern and Pilar Blancafort. https://www.nature.com/articles/s41467-021-22101-7

Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin – David Papadopoli , Oro Uchenunu, Ranveer Palia, Nabila Chekkal, Laura Hulea, Ivan Topisirovic , Michael Pollak, Julie St-Pierre. https://www.sciencedirect.com/science/article/pii/S1476558621000099

Control of endothelial quiescence by FOXO-regulated metabolites – Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza and Michael Potente. https://www.nature.com/articles/s41556-021-00637-6

Metabolic heterogeneity of human hepatocellular carcinoma: implications for personalized pharmacological treatment – Nikolaus Berndt, Johannes Eckstein, Niklas Heucke, Tilo Wuensch, Robert Gajowski, Martin Stockmann, David Meierhofer, Hermann‐Georg Holzhütter. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15587

Proteogenomic and metabolomic characterization of human glioblastoma – Liang-Bo Wang, Alla Karpova, Marina A. Gritsenko et al. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00050-7


Reviews


Metabolic barriers to cancer immunotherapy – Kristin DePeaux and Greg M. Delgoffe. https://www.nature.com/articles/s41577-021-00541-y

Autophagy in tumour immunity and therapy – Houjun Xia, Douglas R. Green and Weiping Zou.  https://www.nature.com/articles/s41568-021-00344-2

Signaling Pathways Involved in Nutrient Sensing Control in Cancer Stem Cells: An Overview – Martha Robles-Flores, Angela P Moreno-Londoño, M Cristina Castañeda-Patlán. https://www.frontiersin.org/articles/10.3389/fendo.2021.627745/full

Linking Serine/Glycine Metabolism to Radiotherapy Resistance – Sánchez-Castillo A, Vooijs M, Kampen KR. https://www.mdpi.com/2072-6694/13/6/1191

Mitochondrial metabolism as a target for acute myeloid leukemia treatment – Svetlana B. Panina, Jingqi Pei and Natalia V. Kirienko. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00253-w

Metabolic implications of non-electrogenic ATP/ADP exchange in cancer cells: A mechanistic basis for the Warburg effect – John J. Lemasters. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000438

Mitochondrial proton leaks and uncoupling proteins – David G. Nicholls. https://www.sciencedirect.com/science/article/pii/S000527282100061X

Glutathione and its precursors in cancer – Gloria Asantewaa, Isaac S Harris. https://www.sciencedirect.com/science/article/abs/pii/S0958166921000458


Comments


Mitochondrial NADPH is a pro at Pro synthesis – Frances F. Diehl and Matthew G. Vander Heiden. https://www.nature.com/articles/s42255-021-00381-z

Fatty acid synthesis enables brain metastasis – Felix C. E. Vogel and Almut Schulze. https://www.nature.com/articles/s43018-021-00202-y

Macropinocytosis: the big drinker behind cancer cell self-consumption – Hua Su, Fei Yang, Beicheng Sun and Michael Karin. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1919969

Glucose makes Treg lose their temper – Matteo Villa, David O’Sullivan, Erika L. Pearce. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00159-8

Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress? – Ralf Baumeister, Coleen T. Murphy and Thomas Heimbucher. https://www.nature.com/articles/s41418-021-00741-y


Conference: SIBBM 2021 “FRONTIERS IN METABOLIC RESEARCH” virtual meeting – June 7th – 10th, 2021

Organized by Graziano Martello, Sirio Dupont, Massimo Santoro. https://sibbm2021.azuleon.org/welcome

MetaboList – March 2021


Nucleotides


5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING – Jingru Tian, Dingyao Zhang, Vadim Kurbatov, Qinrong Wang, Yadong Wang, Dorthy Fang, Lizhen Wu, Marcus Bosenberg, Mandar D Muzumdar, Sajid Khan, Qianjin Lu, Qin Yan, Jun Lu. https://www.embopress.org/doi/abs/10.15252/embj.2020106065

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth – Qian Wang, Yi F. Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Natasha Freidman, Lisa G. Horvath, Nigel Turner, Jeff Holst. https://onlinelibrary.wiley.com/doi/10.1002/path.5665

Rewiring of purine metabolism in response to acidosis stress in glioma stem cells – Xiaoyu Xu, Liping Wang, Qingce Zang, Shanshan Li, Limei Li, Zhixing Wang, Jiuming He, Boqin Qiang, Wei Han, Ruiping Zhang, Xiaozhong Peng and Zeper Abliz. https://www.nature.com/articles/s41419-021-03543-9


Glucose metabolism


The deubiquitinase JOSD2 is a positive regulator of glucose metabolism – Lyudmila Krassikova, Boxi Zhang, Divya Nagarajan, André Lima Queiroz, Merve Kacal, Evangelos Samakidis, Helin Vakifahmetoglu-Norberg and Erik Norberg. https://www.nature.com/articles/s41418-020-00639-1

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation – Sébastien Coassolo, Guillaume Davidson, Luc Negroni, Giovanni Gambi, Sylvain Daujat, Christophe Romier and Irwin Davidson. https://www.nature.com/articles/s41467-021-21960-4

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation – Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, Ni Tang. https://www.jci.org/articles/view/144703

SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells – Joshua A. Mason, Jordan A. Cockfield, Daniel J. Pape, Hannah Meissner, Michael T. Sokolowski, Taylor C. White, José C. Valentín López, Juan Liu, Xiaojing Liu, Inmaculada Martínez-Reyes, Navdeep S. Chandel, Jason W. Locasale, Zachary T. Schafer. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00135-2

Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients – Liu Yang, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, Zhuo Wang, Yu Dong, Dongqing Zuo, Min Xue, Yin Tang, Harvey R. Herschman, Shun Lu, Qihui Shi, and Wei Wei. https://www.pnas.org/content/118/11/e2012228118.abstract?etoc

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis – Xun Shangguan, Jianli He, Zehua Ma, Weiwei zhang, Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li, Zhixiang Xin, Quan Zheng, Ying Cao, Jiahua Pan, Baijun Dong, Jinke Cheng, Qi Wang and Wei Xue. https://www.nature.com/articles/s41467-021-22163-7

A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism – Pratik Shriwas, Dennis Roberts, Yunsheng Li, Liyi Wang, Yanrong Qian, Stephen Bergmeier, Jennifer Hines, Subhodip Adhicary, Corinne Nielsen and Xiaozhuo Chen. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00248-7

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis – Xiaoqing Luo, Enze Zheng, Li Wei, Han Zeng, Hong Qin, Xiaoyu Zhang, Meng Liao, Lin Chen, Lei Zhao, Xiong Z. Ruan, Ping Yang and Yaxi Chen. https://www.nature.com/articles/s41419-021-03596-w

Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma – Hong Xie, Jun Song, Jason Godfrey, Romain Riscal, Nicolas Skuli, Itzhak Nissim and M. Celeste Simon. https://www.nature.com/articles/s42255-021-00367-x

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis – Ying Qing, Lei Dong, Lei Gao, Chenying Li, Yangchan Li, Li   Han, Emily Prince, Brandon Tan, Xiaolan Deng, Collin Wetzel, Chao Shen, Min   Gao, Zhenhua Chen, Wei Li, Bin Zhang, Daniel Braas, Johanna ten Hoeve,   Gerardo Javier Sanchez, Huiying Chen, Lai N. Chan, Chun-Wei Chen, David Ann,   Lei Jiang, Markus Müschen, Guido Marcucci, David R. Plas, Zejuan Li, Rui Su, Jianjun Chen. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30947-3

Basigin drives intracellular accumulation of l-lactate by  harvesting protons and substrate anions – Anna-Lena Köpnick, Annika Jansen, Katharina Geistlinger, Nathan Hugo Epalle, Eric Beitz. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249110


Amino acid metabolism


mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation – Yilei Zhang, Robert V. Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen, Shu-Bing Qian and Boyi Gan. https://www.nature.com/articles/s41467-021-21841-w

Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression – Georgina D. Barnabas, Joo Sang Lee, Tamar Shami, Michal Harel, Lir Beck, Michael Selitrennik, Livnat Jerby-Arnon, Neta Erez, Eytan Ruppin and Tamar Geiger. https://cancerres.aacrjournals.org/content/81/6/1443

A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer – Lingfan Xu, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, James Beasley, Patricia McCaw, Haoyue Zhang, Sarah Young, Jeff Groth, Qianben Wang, Jason W. Locasale, Xia Gao, Dean G. Tang, Xuesen Dong, Yiping He, Daniel George, Hailiang Hu, and Jiaoti Huang. https://www.pnas.org/content/118/13/e2012748118.abstract?etoc

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling – Yamashita AS, da Costa Rosa M, Stumpo V, Rais R, Slusher BS, Riggins GJ.. https://academic.oup.com/noa/article/3/1/vdaa149/5943017

STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition – Piyada Sitthideatphaiboon, Ana Galan-Cobo, Marcelo V. Negrao, Xiao Qu, Alissa Poteete, Fahao Zhang, Diane D. Liu, Whitney E. Lewis, Haley N. Kemp, Jeff Lewis, Waree Rinsurongkawong, Uma Giri, J. Jack Lee, Jianjun Zhang, Jack A. Roth, Stephen Swisher and John V. Heymach. https://clincancerres.aacrjournals.org/content/27/6/1720


Lipid metabolism


Structure and inhibition mechanism of the human citrate transporter NaCT – David B. Sauer, Jinmei Song, Bing Wang, Jacob K. Hilton, Nathan K. Karpowich, Joseph A. Mindell, William J. Rice and Da-Neng Wang. https://www.nature.com/articles/s41586-021-03230-x

Statins repress hedgehog signaling in medulloblastoma with no bone toxicities – Qianhai Fan, Tingting Gong, Chaonan Zheng, Jessica M. Y. Ng, Jianquan Chen, Cynthia Myers, Harvey Hensley, Tom Curran and Zeng-jie Yang. https://www.nature.com/articles/s41388-021-01701-z

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer – Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen and Lisa M. Butler. https://cancerres.aacrjournals.org/content/81/7/1704


Mitochondria


Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia – Chiqi Chen , Xiaoxin Hao, Xiaoyun Lai, Ligen Liu, Jun Zhu, Hongfang Shao, Dan Huang, Hao Gu, Tinghua Zhang, Zhuo Yu, Li Xie, Xiaocui Zhang, Yi Yang, Jun Xu, Yuzheng Zhao, Zhigang Lu, Junke Zheng. https://advances.sciencemag.org/content/7/11/eabd6280

Integrated Molecular Characterization of Fumarate Hydratase–deficient Renal Cell Carcinoma – Guangxi Sun, Xingming Zhang, Jiayu Liang, Xiuyi Pan, Sha Zhu, Zhenhua Liu, Cameron M. Armstrong, Jianhui Chen, Wei Lin, Banghua Liao, Tianhai Lin, Rui Huang, Mengni Zhang, Linmao Zheng, Xiaoxue Yin, Ling Nie, Pengfei Shen, Jinge Zhao, Haoran Zhang, Jindong Dai, Yali Shen, Zhiping Li, Jiyan Liu, Junru Chen, Jiandong Liu, Zhipeng Wang, Xudong Zhu, Yuchao Ni, Dan Qin, Ling Yang, Yuntian Chen, Qiang Wei, Xiang Li, Qiao Zhou, Haojie Huang, Jin Yao, Ni Chen and Hao Zeng. https://clincancerres.aacrjournals.org/content/27/6/1734

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism – Michelle Grace Acoba, Ebru S. Selen Alpergin, Santosh Renuse, Lucía Fernández-del-Río, Ya-Wen Lu, Oleh Khalimonchuk, Catherine F. Clarke, Akhilesh Pandey, Michael J. Wolfgang, Steven M. Claypool. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00183-2

Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models – Amer Alasadi, Bin Cao, Jingjing Guo, Hanlin Tao, Juan Collantes, Victor Tan, Xiaoyang Su, David Augeri and Shengkan Jin. https://www.nature.com/articles/s41388-021-01688-7


Starvation / metabolic stress


Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1 – Pei-Yun Tsai, Min-Sik Lee, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S. Hitchcock, Frederick R. Roberts, Peter DelNero, Thomas Hank, Kim C. Honselmann, Vicente Morales Oyarvide, Mari Mino-Kenudson, Clary B. Clish, Ramesh A. Shivdasani, and Nada Y. Kalaany. https://www.pnas.org/content/118/10/e2003014118.abstract?etoc

MAPK signaling regulates c‐MYC for melanoma cell adaptation to asparagine restriction – Gaurav Pathria,  Sachin Verma,  Jun Yin, David A Scott, Ze’ev A Ronai. https://www.embopress.org/doi/abs/10.15252/embr.202051436?campaign=woletoc

Lipid remodeling in response to methionine stress in MDA-MBA-468 triple-negative breast cancer cells – Stacey L Borrego, Johannes Fahrmann, Jue Hou, Da-Wei Lin, Bruce J Tromberg, Oliver Fiehn, Peter Kaiser. https://pubmed.ncbi.nlm.nih.gov/33647277/

LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation – Ruijie Wang, Leixi Cao, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Fengmin Shao, Lirong Zhang, Mian Wu. https://advances.sciencemag.org/content/7/13/eabe5708

Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma – Krista M. Dalton, Timothy L. Lochmann, Konstantinos V. Floros, Marissa L. Calbert, Richard Kurupi, Giovanna T. Stein, Joseph McClanaghan, Ellen Murchie, Regina K. Egan, Patricia Greninger, Mikhail Dozmorov, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Lisa Shock, Jennifer Koblinski, John Glod, Sosipatros A. Boikos, Cyril H. Benes, and Anthony C. Faber. https://www.pnas.org/content/118/13/e2009620118.abstract?etoc

NIK promotes metabolic adaptation of glioblastoma cells to bioenergetic stress – Michael L. Kamradt, Ji-Ung Jung, Kathryn M. Pflug, Dong W. Lee, Victor Fanniel and Raquel Sitcheran. https://www.nature.com/articles/s41419-020-03383-z

Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation – Andrey V. Kuznetsov, Sabzali Javadov, Raimund Margreiter, Michael Grimm, Judith Hagenbuchner, Michael J. Ausserlechner. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000268


mTOR / AMPK


Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis – Xin Zhang, Xiaowen Wang, Ziqiang Yuan, Sarah J. Radford, Chen Liu, Steven K. Libutti, X.F. Steven Zheng. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00144-3

Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation – Wanchun Yang, Dejiang Pang, Mina Chen, Chongyangzi Du, Lanlan Jia, Luoling Wang, Yunling He, Wanxiang Jiang, Liping Luo, Zongyan Yu, Mengqian Mao, Qiuyun Yuan, Ping Tang, Xiaoqiang Xia, Yiyuan Cui, Bo Jing, Alexander Platero, Yanhui Liu, Yuquan Wei, Paul F. Worley, Bo Xiao. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00162-3

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3 – Mathieu Paquette, Leeanna El-Houjeiri, Linda C. Zirden, Pietri Puustinen, Paola Blanchette, Hyeonju Jeong, Kurt Dejgaard, Peter M. Siegel and Arnim Pause. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1898748


Hypoxia


Coenzyme Q biosynthesis inhibition induces HIF‐1α stabilization and metabolic switch toward glycolysis – Irene Liparulo, Christian Bergamini, Marco Bortolus, Natalia Calonghi, Giuseppe Gasparre, Ivana Kurelac, Luca Masin, Nicola Rizzardi, Michela Rugolo, Wenping Wang, Serena J. Aleo, Alisar Kiwan, Cristian Torri, Claudia Zanna, Romana Fato. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15561

The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions – Ersilia Varone, Alessandra Decio, Alexander Chernorudskiy, Lucia Minoli, Laura Brunelli, Federica Ioli, Arianna Piotti, Roberta Pastorelli, Maddalena Fratelli, Marco Gobbi, Raffaella Giavazzi and Ester Zito. https://www.nature.com/articles/s41388-021-01659-y


Cancer Immunometabolism


Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma – Jason Miska, Aida Rashidi, Catalina Lee-Chang, Peng Gao, Aurora Lopez-Rosas, Peng Zhang, Rachel Burga, Brandyn Castro, Ting Xiao, Yu Han, David Hou, Samay Sampat, Alex Cordero, Joshua S. Stoolman, Craig M. Horbinski, Mark Burns, Yana K. Reshetnyak, Navdeep S. Chandel, and Maciej S. Lesniak.  https://advances.sciencemag.org/content/7/8/eabc8929

Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma – Man Hsin Hung, Joo Sang Lee, Chi Ma, Laurence P. Diggs, Sophia Heinrich, Ching Wen Chang, Lichun Ma, Marshonna Forgues, Anuradha Budhu, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Eytan Ruppin, Tim F. Greten and Xin Wei Wang. https://www.nature.com/articles/s41467-021-21804-1

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy – Xia Liu, Celine L. Hartman, Lingyun Li, Carolyn J. Albert, Fusheng Si, Aiqin Gao, Lan Huang, Yangjing Zhao, Wenli Lin, Eddy C. Hsueh, Lizong Shen, Qixiang Shao, Daniel F. Hoft, David A. Ford, Guangyong Peng. https://stm.sciencemag.org/content/13/587/eaaz6314

Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells – Ilkka Liikanen, Colette Lauhan, Sara Quon, Kyla Omilusik, Anthony T. Phan, Laura Barceló Bartrolí, Amir Ferry, John Goulding, Joyce Chen, James P. Scott-Browne, Jason T. Yustein, Nicole E. Scharping, Deborah A. Witherden, and Ananda W. Goldrath. https://www.jci.org/articles/view/143729


Miscellaneous


MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis – Konstantinos V. Floros, JinYang Cai, Sheeba Jacob, Richard Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, Benjamin R. Belvin, Bin Hu, Madhavi Puchalapalli, Sivapriya Ramamoorthy, Kimberly Swift, Janina P. Lewis, Mikhail G. Dozmorov, John Glod, Jennifer E. Koblinski, Sosipatros A. Boikos and Anthony C. Faber. https://cancerres.aacrjournals.org/content/81/7/1896

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity – Maik Pietzner, Isobel D. Stewart, Johannes Raffler, Kay-Tee Khaw, Gregory A. Michelotti, Gabi Kastenmüller, Nicholas J. Wareham and Claudia Langenberg. https://www.nature.com/articles/s41591-021-01266-0


Reviews / comments


Amino Acid Depletion Therapies: Starving Cancer Cells to Death – Miriam Butler, Laurens T. van der Meer, Frank N. van Leeuwen. https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(21)00049-7

The metabolic landscape of RAS-driven cancers from biology to therapy – Suman Mukhopadhyay, Matthew G. Vander Heiden and Frank McCormick. https://www.nature.com/articles/s43018-021-00184-x

Cellular metabolism in the defense against microbes – Lena Pernas. http://jcs.biologists.org/content/134/5/jcs252023?etoc

Mitochondrial quality control: from molecule to organelle – Alba Roca-Portoles and Stephen W. G. Tait. https://link.springer.com/article/10.1007/s00018-021-03775-0

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation – Annalisa Roberti, Agustín F. Fernández, Mario F. Fraga. https://www.sciencedirect.com/science/article/pii/S2212877821000053

Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential – Li Na Zhao, Mikael Björklund, Matias J. Caldez, Jie Zheng and Philipp Kaldis. https://www.nature.com/articles/s41388-021-01695-8

A cancerous connection for creatine –  Wei Wong. https://stke.sciencemag.org/content/14/676/eabi7099

MetaboList – February 2021


Glucose metabolism


A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma – Jee-Eun Choi, Carlos Sebastian, Christina M. Ferrer, Caroline A. Lewis, Moshe Sade-Feldman, Thomas LaSalle, Anna Gonye, Begona G. C. Lopez, Walid M. Abdelmoula, Michael S. Regan, Murat Cetinbas, Gloria Pascual, Gregory R. Wojtkiewicz, Giorgia G. Silveira, Ruben Boon, Kenneth N. Ross, Itay Tirosh, Srinivas V. Saladi, Leif W. Ellisen, Ruslan I. Sadreyev, Salvador Aznar Benitah, Nathalie Y. R. Agar, Nir Hacohen and Raul Mostoslavsky. https://www.nature.com/articles/s42255-021-00350-6

Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer – Yinan Xiao, Ling Jin, Chaolin Deng, Ye Guan, Eleftheria Kalogera, Upasana Ray, Prabhu Thirusangu, Julie Staub, Sayantani Sarkar Bhattacharya, Haotian Xu, Xiaoling Fang and Viji Shridhar. https://www.nature.com/articles/s41388-020-01621-4

C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism – Yu Zhang, Qian Yan, Lanqi Gong, Hang Xu, Beilei Liu, Xiaona Fang, Dandan Yu, Lei Li, Ting Wei, Ying Wang, Ching Ngar Wong, Zhaojie Lyu, Ying Tang, Pak Chung Sham and Xin-Yuan Guan. https://www.nature.com/articles/s41388-020-01593-5

The Source of Glycolytic Intermediates in Mammalian Tissues – Tara TeSlaa, Caroline R. Bartman, Connor S.R. Jankowski, Zhaoyue Zhang, Xincheng Xu, Xi Xing, Lin Wang, Wenyun Lu, Sheng Hui, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30728-2


Cysteine / Glutathione


The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals – Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning. https://elifesciences.org/articles/63326

Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis – Muyun Liu, Dan Wang, Yongde Luo, Lianghao Hu, Yawei Bi, Juntao Ji, Haojie Huang, Guoqiang Wang, Liang Zhu, Jianjia Ma, Eunice Kim, Catherine K. Luo, James L. Abbruzzese, Xiaokun Li, Vincent W. Yang, Zhaoshen Li and Weiqin Lu. https://www.nature.com/articles/s41419-021-03473-6

Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11 – Subhadip Mukhopadhyay, Douglas E. Biancur, Seth J. Parker, Keisuke Yamamoto, Robert S. Banh, Joao A. Paulo, Joseph D. Mancias, and Alec C. Kimmelman. https://www.pnas.org/content/118/6/e2021475118.abstract?etoc


Amino acid metabolism


Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth – Abigail S. Krall, Peter J. Mullen, Felicia Surjono, Milica Momcilovic, Ernst W. Schmid, Christopher J. Halbrook, Apisadaporn Thambundit, Steven D. Mittelman, Costas A. Lyssiotis, David B. Shackelford, Simon R.V. Knott, Heather R. Christofk. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00057-7

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma – Shuai Wu, Takeshi Fukumoto, Jianhuang Lin, Timothy Nacarelli, Yemin Wang, Dionzie Ong, Heng Liu, Nail Fatkhutdinov, Joseph A. Zundell, Sergey Karakashev, Wei Zhou, Lauren E. Schwartz, Hsin-Yao Tang, Ronny Drapkin, Qin Liu, David G. Huntsman, Andrew V. Kossenkov, David W. Speicher, Zachary T. Schug, Chi Van Dang and Rugang Zhang. https://www.nature.com/articles/s43018-020-00160-x

Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc− for Glutathione Synthesis in Lung Cancer – Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P. Zhou, Shu-Hai Lin and Jiong Deng. https://cancerres.aacrjournals.org/content/81/3/552


Lipid metabolism


Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer – Nicole Oatman , Nupur Dasgupta, Priyanka Arora, Kwangmin Choi, Mruniya V. Gawali, Nishtha Gupta, Sreeja Parameswaran, Joseph Salomone, Julie A. Reisz, Sean Lawler, Frank Furnari, Cameron Brennan, Jianqiang Wu, Larry Sallans, Gary Gudelsky, Pankaj Desai, Brian Gebelein, Matthew T. Weirauch, Angelo D’Alessandro, Kakajan Komurov, Biplab Dasgupta. https://advances.sciencemag.org/content/7/7/eabd7459

LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer – Ramona Rudalska, Jule Harbig, Marteinn T. Snaebjornsson, Sabrina Klotz, Stefan Zwirner, Liudmyla Taranets, Florian Heinzmann, Thales Kronenberger, Michael Forster, Wei Cui, Luana D’Artista, Elias Einig, Martina Hinterleitner, Werner Schmitz, Agata Dylawerska, Tae-Won Kang, Antti Poso, Mathias T. Rosenfeldt, Nisar P. Malek, Michael Bitzer, Stefan Laufer, Bernd J. Pichler, Nikita Popov, Almut Schulze, Lars Zender and Daniel Dauch. https://www.nature.com/articles/s43018-020-00168-3

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis – Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh III, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00080-2

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer – Ji-Yoon Lee, Miso Nam, Hye Young Son, Kwangbeom Hyun, Seo Young Jang, Jong Woo Kim, Min Wook Kim, Youngae Jung , Eunji Jang, Seon-Jin Yoon 8, Jungeun Kim, Jihye Kim, Jinho Seo, Jeong-Ki Min, Kyoung-Jin Oh, Baek-Soo Han, Won Kon Kim, Kwang-Hee Bae, Jaewhan Song, Jaehoon Kim, Yong-Min Huh, Geum-Sook Hwang, Eun-Woo Lee, Sang Chul Lee. https://www.pnas.org/content/117/51/32433.long

Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth – Katelyn D. Miller, Katherine Pniewski, Caroline E. Perry, Sara B. Papp, Joshua D. Shaffer, Jesse N. Velasco-Silva, Jessica C. Casciano, Tomas M. Aramburu, Yellamelli V.V. Srikanth, Joel Cassel, Emmanuel Skordalakes, Andrew V. Kossenkov, Joseph M. Salvino and Zachary T. Schug. https://cancerres.aacrjournals.org/content/81/5/1252

The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis – Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H.K. Wong, Ben S. Wittner, Hongshan Guo, Taronish D. Dubash, Moshe Sade-Feldman, Benjamin Wesley, Elad Horwitz, Genevieve M. Boland, Dieuwke L. Marvin, Todd Bonesteel, Chenyue Lu, François Aguet, Risa Burr, Samuel S. Freeman, Laxmi Parida, Katherine Calhoun, Michelle K. Jewett, Linda T. Nieman, Nir Hacohen, Anders M. Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran and Daniel A. Haber. https://cancerdiscovery.aacrjournals.org/content/11/3/678


Mitochondria


Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells – Nont Kosaisawe, Breanne Sparta, Michael Pargett, Carolyn K. Teragawa, John G. Albeck. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00014-0

Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential – Sarah Courtois, Beatriz de Luxán-Delgado, Laure Penin-Peyta, Alba Royo-García, Beatriz Parejo-Alonso, Petra Jagust, Sonia Alcalá, Juan A. Rubiolo, Laura Sánchez 5, Bruno Sainz, Jr., Christopher Heeschen, and Patricia Sancho. https://www.mdpi.com/2072-6694/13/4/698#

BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver – Maya Z. Springer, Logan P. Poole, Lauren E. Drake, Althea Bock-Hughes, Michelle L Boland, Alexandra G. Smith, John Hart, Aparajita H. Chourasia, Ivan Liu, Grazyna Bozek and Kay F Macleod. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1877469

Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities – Luciano Garofano, Simona Migliozzi, Young Taek Oh, Fulvio D’Angelo, Ryan D. Najac, Aram Ko, Brulinda Frangaj, Francesca Pia Caruso, Kai Yu, Jinzhou Yuan, Wenting Zhao, Anna Luisa Di Stefano, Franck Bielle, Tao Jiang, Peter Sims, Mario L. Suvà, Fuchou Tang, Xiao-Dong Su, Michele Ceccarelli, Marc Sanson, Anna Lasorella and Antonio Iavarone. https://www.nature.com/articles/s43018-020-00159-4

The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters – Florian A. Schober, David Moore, Ilian Atanassov, Marco F. Moedas, Paula Clemente, Ákos Végvári, Najla El Fissi, Roberta Filograna, Anna-Lena Bucher, Yvonne Hinze, Matthew The, Erik Hedman, Ekaterina Chernogubova, Arjana Begzati, Rolf Wibom, Mohit Jain, Roland Nilsson, Lukas Käll, Anna Wedell, Christoph Freyer, Anna Wredenberg. https://advances.sciencemag.org/content/7/8/eabf0717

Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability – Chen-Hua Chuang, Madeleine Dorsch, Philip Dujardin, Sukrit Silas, Kristina Ueffing, Johanna M. Hölken, Dian Yang, Monte M. Winslow and Barbara M. Grüner. https://cancerres.aacrjournals.org/content/81/3/567


Starvation, AMPK


CRISPR screens in physiologic medium reveal conditionally essential genes in human cells – Nicholas J. Rossiter, Kimberly S. Huggler, Charles H. Adelmann, Heather R. Keys, Ross W. Soens, David M. Sabatini, Jason R. Cantor.. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00061-9

Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation – Andrey V Kuznetsov, Sabzali Javadov, Raimund Margreiter, Michael Grimm, Judith Hagenbuchner, Michael J Ausserlechner. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000268

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53 – Peng Jiang, Lejiao Ren, Li Zhi, Zhong Yu, Fengxiang Lv, Fengli Xu, Wei Peng, Xiaoyu Bai, Kunlun Cheng, Li Quan, Xiuqin Zhang, Xianhua Wang, Yan Zhang, Dan Yang, Xinli Hu, Rui-Ping Xiao. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30900-X

AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ – Yuejing Jiang, Ying Dong, Yifeng Luo, Shangwen Jiang, Fei-Long Meng, Minjia Tan, Jia Li, Yi Zang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00026-7

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner – Franziska Kopietz; Yazeed Alshuweishi; Silvia Bijland; Fatmah Alghamdi; Eva Degerman; Kei Sakamoto; Ian P. Salt, Olga Göransson. https://portlandpress.com/biochemj/article-abstract/478/3/633/227673/


mTOR


G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling – Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van ‘t Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck. https://www.cell.com/cell/fulltext/S0092-8674(20)31694-9

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C – Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, Emma Y. Wu, Matthew Kukurugya, Claire F. Maher, Rushika M. Perera, M. Paulina Ordonez, Roberto Zoncu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30925-4


Hypoxia


Homology-directed repair protects the replicating genome from metabolic assaults – Kumar Somyajit, Julian Spies, Fabian Coscia, Ufuk Kirik, Maj-Britt Rask, Ji-Hoon Lee, Kai John Neelsen, Andreas Mund, Lars Juhl Jensen, Tanya T. Paull, Matthias Mann, Jiri Lukas. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00069-1

The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI) – Yukino Kobayashi, Ami Oguro, Yuta Hirata, Susumu Imaoka. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246531

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis – Fang Zheng, Jianing Chen and Erwei Song. https://www.nature.com/articles/s41467-021-21535-3


Cancer Immunometabolism


Metabolic support of tumour-infiltrating regulatory T cells by lactic acid – McLane J. Watson, Paolo D. A. Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie L. Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, Dario A. A. Vignali, Timothy W. Hand, Amanda C. Poholek, Brett M. Morrison, Jeffrey D. Rothstein, Stacy G. Wendell and Greg M. Delgoffe. https://www.nature.com/articles/s41586-020-03045-2

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours – Roberta Zappasodi, Inna Serganova, Ivan J. Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M. Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok and Taha Merghoub. https://www.nature.com/articles/s41586-021-03326-4

Lipid signalling enforces functional specialization of Treg cells in tumours – Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel and Hongbo Chi. https://www.nature.com/articles/s41586-021-03235-6

Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors – Jang Hyun Park, Hyun-Jin Kim, Chae Won Kim, Hyeon Cheol Kim, Yujin Jung, Hyun-Soo Lee, Yunah Lee, Young Seok Ju, Ji Eun Oh, Sung-Hong Park, Jeong Ho Lee, Sung Ki Lee and Heung Kyu Lee. https://www.nature.com/articles/s41590-020-00860-7


Miscellaneous


NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes – Anju Singh, Anneleen Daemen, Dorothee Nickles, Sang-Min Jeon, Oded Foreman, Kuladeep Sudini, Florian Gnad, Stephane Lajoie, Naina Gour, Wayne Mitzner, Samit Chatterjee, Eun-Ji Choi, Buvana Ravishankar, Amy Rappaport, Namrata Patil, Mark McCleland, Leisa Johnson, George Acquaah-Mensah, Edward Gabrielson, Shyam Biswal and Georgia Hatzivassiliou. https://clincancerres.aacrjournals.org/content/27/3/877

Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation – Jung-Chin Chang, Simei Go, Eduardo H. Gilglioni, Suzanne Duijst, Daan M. Panneman, Richard J. Rodenburg, Hang Lam Li, Hsu-Li Huang, Lonny R. Levin, Jochen Buck, Arthur J. Verhoeven, Ronald P.J. Oude Elferink. https://www.sciencedirect.com/science/article/pii/S0005272820302176

NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition – Alexandra M. Moore, Lei Zhou, Jing Cui, Luyi Li, Nanping Wu, Alice Yu, Soumya Poddar, Keke Liang, Evan R. Abt, Stephanie Kim, Razmik Ghukasyan, Nooneh Khachatourian, Kristina Pagano, Irmina Elliott, Amanda M. Dann, Rana Riahi, Thuc Le, David W. Dawson, Caius G. Radu, and Timothy R. Donahue. https://www.pnas.org/content/118/8/e2012469118.abstract?etoc

Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism – Ling-Yan Cai, Shi-Jie Chen, Sen-Hao Xiao, Qin-Juan Sun, Chen-Hong Ding, Bai-Nan Zheng, Xin-Yan Zhu, Shu-Qing Liu, Feng Yang, Ya-Xi Yang, Bing Zhou, Cheng Luo, Xin Zhang and Wei-Fen Xie. https://cancerres.aacrjournals.org/content/81/4/860

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer – Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, François Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji-Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. Dannenberg, Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00056-5

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice – Padma Kadiyala, Stephen V. Carney, Jessica C. Gauss, Maria B. Garcia-Fabiani, Santiago Haase, Mahmoud S. Alghamri, Felipe J. Núñez, Yayuan Liu, Minzhi Yu, Ayman Taher, Fernando M. Nunez, Dan Li, Marta B. Edwards, Celina G. Kleer, Henry Appelman, Yilun Sun, Lili Zhao, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, and Maria G. Castro. https://www.jci.org/articles/view/139542


Reviews


The metabolism of cancer cells during metastasis – Gabriele Bergers and Sarah-Maria Fendt. https://www.nature.com/articles/s41568-020-00320-2

Flexibility and Adaptation of Cancer Cells in a Heterogenous Metabolic Microenvironment – Gabriele Grasmann, Ayusi Mondal and Katharina Leithner. https://www.mdpi.com/1422-0067/22/3/1476

Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology – Elisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo and Javier A. Menendez. https://www.frontiersin.org/articles/10.3389/fonc.2020.620641/full

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases – Yanghe Zhang, Qingfei Meng, Qianhui Sun, Zhi-Xiang Xu, Honglan Zhou, Yishu Wang. https://www.sciencedirect.com/science/article/pii/S2212877820302052

Mitophagy in tumorigenesis and metastasis – Logan P Poole, Kay F Macleod. https://link.springer.com/article/10.1007%2Fs00018-021-03774-1

Mitochondrial dynamics in cancer stem cells – Dane T. Sessions and David F. Kashatus. https://link.springer.com/article/10.1007/s00018-021-03773-2


Comments


New Insights into Oncogenic Transformation: Elevating Antioxidant and Nucleotide Levels Does the Trick – Rushendhiran Kesavan, Halie Rion, Gerta Hoxhaj. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00016-9

Lethal lipotoxicity for liver cancer therapy – Suchira Gallage, Jose Efren Barragan Avila and Mathias Heikenwalder. https://www.nature.com/articles/s43018-021-00175-y

Activating T cells with asparagine – Wei Wong. https://stke.sciencemag.org/content/14/668/eabc6178

Tumour-regulated anorexia preceding cachexia – Gang Wang, Haiying Zhang and David Lyden. https://www.nature.com/articles/s41556-021-00635-8

How does obesity promote breast cancer tumor growth? – Marc L. Reitman. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00067-X

Obesity Promotes Metabolic Rewiring That Starves Cytotoxic T Cells – https://cancerdiscovery.aacrjournals.org/content/11/2/222.1

A Lung Cancer Subtype Depends on the Hexosamine Biosynthesis Pathwayhttps://cancerdiscovery.aacrjournals.org/content/11/2/OF9

Cryo-EM Structures Reveal Mechanism of Anticancer MCT1 Inhibitorshttps://cancerdiscovery.aacrjournals.org/content/11/3/529.2


James R. Mitchell (1971–2020) – Michael Ristow, Chih-Hao Lee, Katrien De Bock, Vadim N. Gladyshev, Gökhan S. Hotamisligil, Brendan D. Manning. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00065-6

MetaboList – January 2021


Metabolic pathways (general) and cancer


Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets – Yue Gong, Peng Ji, Yun-Song Yang, Xin Hu, Yi-Zhou Jiang, Zhi-Ming Shao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30545-3

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer – Douglas E. Biancur, Kevin S. Kapner, Keisuke Yamamoto, Robert S. Banh, Jasper E. Neggers, Albert S.W. Sohn, Warren Wu, Robert T. Manguso, Adam Brown, David E. Root, Andrew J. Aguirre, Alec C. Kimmelman. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30551-9

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells – Xiphias Ge Zhu, Aleksey Chudnovskiy, Lou Baudrier, Benjamin Prizer, Yuyang Liu, Benjamin N. Ostendorf, Norihiro Yamaguchi, Abolfozl Arab, Bernardo Tavora, Rebecca Timson, Søren Heissel, Elisa de Stanchina, Henrik Molina, Gabriel D. Victora, Hani Goodarzi, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30550-7

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma – James Reigle, Dina Secic, Jacek Biesiada, Collin Wetzel, Behrouz Shamsaei, Johnson Chu, Yuanwei Zang, Xiang Zhang, Nicholas J. Talbot, Megan E. Bischoff, Yongzhen Zhang, Charuhas V. Thakar, Krishnanath Gaitonde, Abhinav Sidana, Hai Bui, John T. Cunningham, Qing Zhang, Laura S. Schmidt, W. Marston Linehan, Mario Medvedovic, David R. Plas, Julio A. Landero Figueroa, Jarek Meller, and Maria F. Czyzyk-Krzeska. https://www.jci.org/articles/view/140522

Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes – Karl Kochanowski, Timur Sander, Hannes Link, Jeremy Chang, Steven J. Altschuler, Lani F. Wu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31636-3

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors – Anna Han, Timothy J. Purwin, Nelisa Bechtel, Connie Liao, Vivian Chua, Erin Seifert, Takami Sato, Zachary T. Schug, David W. Speicher, J. William Harbour and Andrew E. Aplin. https://www.nature.com/articles/s41388-020-01554-y

Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI – Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen and May-Britt Tessem. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00242-z


Hexose metabolism


Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer – Catríona M. Dowling , Kate E. R. Hollinshead, Alessandra Di Grande, Justin Pritchard, Hua Zhang, Eugene T. Dillon, Kathryn Haley, Eleni Papadopoulos, Anita K. Mehta, Rachel Bleach, Andreas U. Lindner, Brian Mooney, Heiko Düssmann, Darran O’Connor, Jochen H. M. Prehn, Kieran Wynne, Michael Hemann, James E. Bradner, Alec C. Kimmelman, Jennifer L. Guerriero, Gerard Cagney, Kwok-Kin Wong, Anthony G. Letai, Tríona Ní Chonghaile. https://advances.sciencemag.org/content/7/3/eabc4897

The harsh microenvironment in early breast cancer selects for a Warburg phenotype – Mehdi Damaghi, Jeffrey West, Mark Robertson-Tessi, Liping Xu, Meghan C. Ferrall-Fairbanks, Paul A. Stewart, Erez Persi, Brooke L. Fridley, Philipp M. Altrock, Robert A. Gatenby, Peter A. Sims, Alexander R. A. Anderson, and Robert J. Gillies. https://www.pnas.org/content/118/3/e2011342118.abstract?etoc

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex – Xuxiao He, Min Li, Hongming Yu, Guijun Liu, Ningning Wang, Chunzhao Yin, Qiaochu Tu, Goutham Narla, Yongzhen Tao, Shuqun Cheng, Huiyong Yin. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000803

Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells – Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem and Stefan Wölfl. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00239-8

Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment – Yongbo Yu, Ye Liang, Dan Li, Liping Wang, Zhijuan Liang, Yuanbin Chen, Guofeng Ma, Hui Wu, Wei Jiao and Haitao Niu. https://www.nature.com/articles/s41420-021-00401-7

Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with localized primary gastrointestinal stromal tumors – Sang Hyun Hwang, Minkyu Jung, Yong Hyu Jeong, KwanHyeong Jo, Soyoung Kim, Jiyoung Wang and Arthur Cho. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00244-x

Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells – Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman and P. Darrell Neufer. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00241-0


Lactate


An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism – Nunu Huang, Fanying Li, Maolei Zhang, Huangkai Zhou, Zhipeng Chen, Xiaoyan Ma, Lixuan Yang, Xujia Wu, Jian Zhong, Feizhe Xiao, Xuesong Yang, Kun Zhao, Xixi Li, Xin Xia, Zexian Liu, Song Gao, Nu Zhang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30663-X

Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export – Ke Wang, Wan Huang, Ruo Chen, Peng Lin, Tao Zhang, Yun-Feng Ni, Hao Li, Jiao Wu, Xiu-Xuan Sun, Jie-Jie Geng, Yu-Meng Zhu, Gang Nan, Wei Zhang, Xi Chen, Ping Zhu, Huijie Bian, Zhi-Nan Chen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30660-4

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates – Nan Wang, Xin Jiang, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan. https://www.cell.com/cell/fulltext/S0092-8674(20)31615-9


Amino acid metabolism


The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer – Arafath K. Najumudeen, Fatih Ceteci, Sigrid K. Fey, Gregory Hamm, Rory T. Steven, Holly Hall, Chelsea J. Nikula, Alex Dexter, Teresa Murta, Alan M. Race, David Sumpton, Nikola Vlahov, David M. Gay, John R. P. Knight, Rene Jackstadt, Joshua D. G. Leach, Rachel A. Ridgway, Emma R. Johnson, Colin Nixon, Ann Hedley, Kathryn Gilroy, William Clark, Sudhir B. Malla, Philip D. Dunne, Giovanny Rodriguez-Blanco, Susan E. Critchlow, Agata Mrowinska, Gaurav Malviya, Dmitry Solovyev, Gavin Brown, David Y. Lewis, Gillian M. Mackay, Douglas Strathdee, Saverio Tardito, Eyal Gottlieb, CRUK Rosetta Grand Challenge Consortium, Zoltan Takats, Simon T. Barry, Richard J. A. Goodwin, Josephine Bunch, Martin Bushell, Andrew D. Campbell and Owen J. Sansom. https://www.nature.com/articles/s41588-020-00753-3

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy – Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom and Karen H. Vousden. https://www.nature.com/articles/s41467-020-20223-y

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis – Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S. Harris, Gina M. DeNicola. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30662-8

Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma – Richa Rathore, Katharine E. Caldwell, Charles Schutt, Caitlyn B. Brashears, Bethany C. Prudner, William R. Ehrhardt, Cheuk Hong Leung, Heather Lin, Najat C. Daw, Hannah C. Beird, Abigail Giles, Wei-Lien Wang, Alexander J. Lazar, John S.A. Chrisinger, J. Andrew Livingston, Brian A. Van Tine. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31667-3

Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer – Deanna N. Edwards, Verra M. Ngwa, Ariel L. Raybuck, Shan Wang, Yoonha Hwang, Laura C. Kim, Sung Hoon Cho, Yeeun Paik, Qingfei Wang, Siyuan Zhang, H. Charles Manning, Jeffrey C. Rathmell, Rebecca S. Cook, Mark R. Boothby, Jin Chen. https://www.jci.org/articles/view/140100

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells – Sangmoo Jeong, Angela Maria Savino, Rachel Chirayil, Ersilia Barin, Yuanming Cheng, Sun-Mi Park, Alexandra Schurer, Edouard Mullarky, Lewis C. Cantley, Michael G. Kharas, Kayvan R. Keshari. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30665-3

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells – Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S. https://www.mdpi.com/2072-6694/13/3/412

Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells – Leonard C. Rogers, Jing Zhou, Adriana Baker, Charles R. Schutt, Prashanta K. Panda and Brian A. Van Tine. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00238-9


Lipid metabolism


Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas – Nivea Dias Amoedo, Saharnaz Sarlak, Emilie Obre, Pauline Esteves, Hugues Bégueret, Yann Kieffer, Benoît Rousseau, Alexis Dupis, Julien Izotte, Nadège Bellance, Laetitia Dard, Isabelle Redonnet-Vernhet, Giuseppe Punzi, Mariana Figueiredo Rodrigues, Elodie Dumon, Walid Mafhouf, Véronique Guyonnet-Dupérat, Lara Gales, Tony Palama, Floriant Bellvert, Nathalie Dugot-Senan, Stéphane Claverol, Jean-Marc Baste, Didier Lacombe, Hamid Reza Rezvani, Ciro Leonardo Pierri, Fatima Mechta-Grigoriou, Matthieu Thumerel, and Rodrigue Rossignol. https://www.jci.org/articles/view/133081

Phospholipid dynamics in ex vivo lung cancer and normal lung explants – Julia Lesko, Alexander Triebl, Elvira Stacher-Priehse, Nicole Fink-Neuböck, Jörg Lindenmann, Freyja-Maria Smolle-Jüttner, Harald C. Köfeler, Andelko Hrzenjak, Horst Olschewski & Katharina Leithner. https://www.nature.com/articles/s12276-020-00547-x

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma – Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E. Davis, Pei Lin, P. Leif Bergsagel, Elisabet E. Manasanch, Stephen T.C. Wong, Nestor F. Esnaola, Jenny C. Chang, Robert Z. Orlowski, Qing Yi, Jing Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30666-5

A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer – Krishna B. Singh, Eun-Ryeong Hahm, Su-Hyeong Kim, Stacy G. Wendell and Shivendra V. Singh. https://www.nature.com/articles/s41388-020-01553-z

2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis – Liang Sun, Xiaoqin Yang, Xiaoheng Huang, Yizhou Yao, Xiangyu Wei, Shugao Yang, Diyuan Zhou, Wei Zhang, Zhimin Long, Xiaoyan Xu, Xinguo Zhu, Songbing He and Xiong Su. https://cancerres.aacrjournals.org/content/81/2/289

Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation – Qingyu Zhang, Wei Zhou, Shan Yu, Yaojun Ju, Sally Kit Yan To, Alice Sze Tsai Wong, Yufei Jiao, Terence Chuen Wai Poon, Kin Yip Tam and Leo Tsz On Lee. https://www.nature.com/articles/s41388-020-01516-4


Nucleotides and NADPH


Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation – Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M. Ghergurovich, Lili Guo, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30535-0

Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model – Martin P. Ogrodzinski, Shao Thing Teoh and Sophia Y. Lunt. https://cancerres.aacrjournals.org/content/81/2/303

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer – Fang Huang, Kenneth E. Huffman, Zixi Wang, Xun Wang, Kailong Li, Feng Cai, Chendong Yang, Ling Cai, Terry S. Shih, Lauren G. Zacharias, Andrew Chung, Qian Yang, Milind D. Chalishazar, Abbie S. Ireland, C. Allison Stewart, Kasey Cargill, Luc Girard, Yi Liu, Min Ni, Jian Xu, Xudong Wu, Hao Zhu, Benjamin Drapkin, Lauren A. Byers, Trudy G. Oliver, Adi F. Gazdar, John D. Minna, and Ralph J. DeBerardinis. https://www.jci.org/articles/view/139929

NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor comple – Wei Li, Junjie Kou, Junying Qin, Li Li, Zhenxi Zhang, Ying Pan, Yi Xue and Wenjing Du. https://www.nature.com/articles/s42255-020-00330-2


Mitochondrial metabolism


Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer – Daniel R. Crooks , Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, G. Mariah Cawthon, Ferri Sohelian, Natalia De Val, Ruth M. Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa W.-M. Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa, Ashkan A. Malayeri, Maria J. Merino, Youfeng Yang, Jordan L. Meier, Mark W. Ball, Tracey A. Rouault, Ramaprasad Srinivasan, W. Marston Linehan. https://stke.sciencemag.org/content/14/664/eabc4436

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice – Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera & Alessio Nencioni. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00240-1

Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer – Bianca Oresta , Chiara Pozzi, Daniele Braga, Rodolfo Hurle, Massimo Lazzeri, Piergiuseppe Colombo, Nicola Frego, Marco Erreni, Cristina Faccani, Grazia Elefante, Matteo Barcella, Giorgio Guazzoni, Maria Rescigno. https://stm.sciencemag.org/content/13/575/eaba6110

Targeting oxidative phosphorylation to increase the efficacy of radio- and immune- combination therapy – Daan F Boreel, Paul N Span, Sandra Heskamp, Gosse J. Adema and Johan Bussink. https://clincancerres.aacrjournals.org/content/early/2021/01/08/1078-0432.CCR-20-3913


Mitochondrial stress


Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction – Kendall J. Condon, Jose M. Orozco, Charles H. Adelmann, Jessica B. Spinelli, Pim W. van der Helm, Justin M. Roberts, Tenzin Kunchok, and David M. Sabatini. https://www.pnas.org/content/118/4/e2022120118.abstract?etoc

Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response – Kai Mao, Peter Breen, Gary Ruvkun. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000996

Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress – Lingjie Sang, Huai-qiang Ju, Zuozhen Yang, Qiwei Ge, Zhen Zhang, Fangzhou Liu, Luojia Yang, Hangdi Gong, Chengyu Shi, Lei Qu, Hui Chen, Minjie Wu, Hao Chen, Ruihua Li, Qianqian Zhuang, Hailong Piao, Qingfeng Yan, Weishi Yu, Liangjing Wang, Jianzhong Shao, Jian Liu, Wenqi Wang, Tianhua Zhou and Aifu Lin. https://www.nature.com/articles/s42255-020-00325-z

Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration – Zhaoying Yang, Xiaocui Zhao, Weina Shang, Yang Liu, Jun-Feng Ji, Jun-Ping Liu and Chao Tong. https://www.nature.com/articles/s41418-020-0601-5

Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway – Lin Cheng, Xu Zhang, Yu-Zhou Huang, Yu-Lan Zhu, Ling-Yun Xu, Zhi Li, Xin-Yuan Dai, Liang Shi, Xu-Jie Zhou, Ji-Fu Wei and Qiang Ding. https://www.nature.com/articles/s41389-020-00290-y

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development – Zhida Wu, Meiling Zuo, Ling Zeng, Kaisa Cui, Bing Liu, Chaojun Yan, Li Chen, Jun Dong, Fugen Shangguan, Wanglai Hu, He He, Bin Lu, Zhiyin Song. https://www.embopress.org/doi/abs/10.15252/embr.202050827


Starvation response / ATF4


PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner – Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals and Jose C. Perales. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00236-3

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis – Kwontae You, Lingfei Wang, Chih-Hung Chou, Kai Liu, Toru Nakata, Alok Jaiswal, Junmei Yao, Ariel Lefkovith, Abdifatah Omar, Jacqueline G Perrigoue, Jennifer E Towne, Aviv Regev, Daniel B Graham, Ramnik J Xavier. https://science.sciencemag.org/content/371/6524/eabb6896

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program – Rajalakshmi Srinivasan, Adhish S. Walvekar, Zeenat Rashida, Aswin Seshasayee, Sunil Laxman. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009252

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B – Alisa F. Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P. Harding, Ana Crespillo-Casado, Luke A. Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30738-3


mTOR


Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation – Sung-Hoon Kim, Jung-Hyun Choi, Peng Wang, Christopher D. Go, Geoffrey G. Hesketh, Anne-Claude Gingras, Seyed Mehdi Jafarnejad, Nahum Sonenberg. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4

Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma – Liangfang Yao, Yang Xuan, Haiyang Zhang, Bo Yang, Xinglong Ma, Tianzhen Wang, Tianyuan Meng, Wenshe Sun, Haibin Wei, Xueqing Ma, Robb Moses, Jianru Xiao, Pei Zhang, Chao Ge, Jinjun Li, Lei Li, Xiaotao Li, Jinbao Li and Bianhong Zhang. https://www.nature.com/articles/s41388-020-01558-8


Hypoxia


Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation – Omar A. Itani, Xuefei Zhong, Xiaoting Tang, Barbara A. Scott, Jun Yi Yan, Stephane Flibotte, Yiting Lim, Andrew C. Hsieh, James E. Bruce, Marc Van Gilst, C. Michael Crowder. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31505-0

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis – Alina Küper, Jennifer Baumann, Kirsten Göpelt, Melanie Baumann, Christopher Sänger, Eric Metzen, Philip Kranz & Ulf Brockmeier. https://www.nature.com/articles/s41419-020-03319-7


Cancer Immunometabolism


Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion – Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk, Paolo D. A. Vignali, B. Rhodes Ford, Natalie L. Rittenhouse, Ronal Peralta, Yiyang Wang, Yupeng Wang, Kristin DePeaux, Amanda C. Poholek and Greg M. Delgoffe. https://www.nature.com/articles/s41590-020-00834-9

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion – Hongwei Lv, Guishuai Lv, Cian Chen, Qianni Zong, Guoqing Jiang, Dan Ye, Xiuliang Cui, Yufei He, Wei Xiang, Qin Han, Liang Tang, Wen Yang, Hongyang Wang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30554-4

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles – Zhaohan Wei, Xiaoqiong Zhang, Tuying Yong, Nana Bie, Guiting Zhan, Xin Li, Qingle Liang, Jianye Li, Jingjing Yu, Gang Huang, Yuchen Yan, Zelong Zhang, Bixiang Zhang, Lu Gan, Bo Huang and Xiangliang Yang. https://www.nature.com/articles/s41467-020-20723-x


Miscellaneous


Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death – Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta-Leonor Rodriguez, Marta Garcia-Cajide, Virginia Amador, Ramón Salazar, Sara C Kozma, Eric P Kusnadi, Jian Kang, Antonio Gentilella, Richard B Pearson, George Thomas, Joffrey Pelletier. https://ashpublications.org/blood/article/doi/10.1182/blood.2020007452/474958

Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia – Wenjun Hu, Hairong Xiong, Zeyuan Ru, Yan Zhao, Yali Zhou, Kairu Xie, Wen Xiao, Zhiyong Xiong, Cheng Wang, Changfei Yuan, Jian Shi, Quansheng Du, Xiaoping Zhang & Hongmei Yang. https://www.nature.com/articles/s41419-020-03382-0

IDH1 mutations induce organelle defects via dysregulated phospholipids – Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad & Mioara Larion. https://www.nature.com/articles/s41467-020-20752-6


Reviews


Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism – Ilaria Elia and Marcia C. Haigis. https://www.nature.com/articles/s42255-020-00317-z

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers – Gaurav Pathria, Ze’ev A. Ronai. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30664-1

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies – Daqian Xu, Fei Shao, Xueli Bian, Ying Meng, Tingbo Liang, Zhimin Lu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30670-7

Lipid metabolism and cancer – Xueli Bian; Rui Liu; Ying Meng; Dongming Xing; Daqian Xu; Zhimin Lu. https://rupress.org/jem/article-abstract/218/1/e20201606/211616/

Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies – Matthew S. Waitkus and Hai Yan. https://clincancerres.aacrjournals.org/content/27/2/383

Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification – Pilar Espiau-Romera, Sarah Courtois, Beatriz Parejo-Alonso, Patricia Sancho. https://www.mdpi.com/2077-0383/9/12/4128

The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells – Yoshida GJ. https://pubmed.ncbi.nlm.nih.gov/33401672/

Modification of Proteins by Metabolites in Immunity – Diskin, T.A.J. Ryan, L.A.J. O’Neill. https://www.cell.com/immunity/fulltext/S1074-7613(20)30408-8

Immunometabolic Interplay in the Tumor Microenvironment – Irem Kaymak, Kelsey S. Williams, Jason R. Cantor, Russell G. Jones. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30478-5

The diversity and breadth of cancer cell fatty acid metabolism – Shilpa R. Nagarajan, Lisa M. Butler and Andrew J. Hoy. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00237-2

Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts – Weber DD, Thapa M, Aminzadeh-Gohari S, Redtenbacher AS, Catalano L, Feichtinger RG, Koelblinger P, Dallmann G, Emberger M, Kofler B, Lang R.. https://pubmed.ncbi.nlm.nih.gov/33498757/

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia – Valentina Rausch, Valentina Sala, Fabio Penna, Paolo Ettore Porporato & Alessandra Ghigo. https://www.nature.com/articles/s41389-020-00288-6

The ins and outs of serine and glycine metabolism in cancer – Shauni L. Geeraerts, Elien Heylen, Kim De Keersmaecker & Kim R. Kampen. https://www.nature.com/articles/s42255-020-00329-9

Endoplasmic reticulum stress signals in the tumour and its microenvironment – Xi Chen & Juan R. Cubillos-Ruiz. https://www.nature.com/articles/s41568-020-00312-2


Comments


Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target  – Sanne Bootsma, Sanne M. van Neerven and Louis Vermeulen. https://www.nature.com/articles/s41588-020-00758-y

Food for Growth: Distinct Nutrient Preferences between Primary Tumors and Metastases – Yannick Audet-Delage, Julie St-Pierre. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30965-5

From the T-cell receptor to cancer therapy: an interview with Tak W. Mak – Tak W. Mak. https://www.nature.com/articles/s41418-020-00666-y

MetaboList – December 2020

Serine metabolism


In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition – Gianmarco Rinaldi, Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W Hunter, Sophia Y Lunt, Thomas G P Grünewald, Sarah-Maria Fendt. https://www.sciencedirect.com/science/article/abs/pii/S1097276520308273
 
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells – Sangmoo Jeong, Angela Maria Savino, Rachel Chirayil, Ersilia Barin, Yuanming Cheng, Sun-Mi Park , Alexandra Schurer, Edouard Mullarky, Lewis C Cantley, Michael G Kharas, Kayvan R Keshari. https://www.sciencedirect.com/science/article/abs/pii/S1550413120306604?via%3Dihub



Cystine / Glutathione


Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis – Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S Harris, Gina M DeNicola. https://www.sciencedirect.com/science/article/abs/pii/S1550413120306628
 
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition – Michael S. Binkley, Young-Jun Jeon, Monica Nesselbush, Everett J. Moding, Barzin Y. Nabet, Diego Almanza, Christian Kunder, Henning Stehr, Christopher H. Yoo, Siyeon Rhee, Michael Xiang, Jacob J. Chabon, Emily Hamilton, David M. Kurtz, Linda Gojenola, Susie Grant Owen, Ryan B. Ko, June Ho Shin, Peter G. Maxim, Natalie S. Lui, Leah M. Backhus, Mark F. Berry, Joseph B. Shrager, Kavitha J. Ramchandran, Sukhmani K. Padda, Millie Das, Joel W. Neal, Heather A. Wakelee, Ash A. Alizadeh, Billy W. Loo Jr and Maximilian Diehn. https://cancerdiscovery.aacrjournals.org/content/10/12/1826
 
Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells – Petra Jagust, Sonia Alcalá, Bruno Sainz Jr, Christopher Heeschen, Patricia Sancho. https://www.wjgnet.com/1948-0210/abstract/v12/i11/1410.htm


Glutamine and other amino acids


KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth – Susanna Raho, Loredana Capobianco, Rocco Malivindi, Angelo Vozza, Carmela Piazzolla, Francesco De Leonardis, Ruggiero Gorgoglione, Pasquale Scarcia, Francesca Pezzuto, Gennaro Agrimi, Simona N. Barile, Isabella Pisano, Stephan J. Reshkin, Maria R. Greco, Rosa A. Cardone, Vittoria Rago, Yuan Li, Carlo M. T. Marobbio, Wolfgang Sommergruber, Christopher L. Riley, Francesco M. Lasorsa, Edward Mills, Maria C. Vegliante, Giuseppe E. De Benedetto, Deborah Fratantonio, Luigi Palmieri, Vincenza Dolce and Giuseppe Fiermonte. https://www.nature.com/articles/s42255-020-00315-1
 
Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma – Yi Xiao, Anja Rabien, René Buschow, Vyacheslav Amtislavskiy, Jonas Busch, Ergin Kilic, Sonia L. Villegas, Bernd Timmermann, Moritz Schütte, Thorsten Mielke, Marie-Laure Yaspo, Klaus Jung and David Meierhofer. https://cancerres.aacrjournals.org/content/80/24/5491
 
BCAT1 affects mitochondrial metabolism independently of leucine  transamination in activated human macrophages – Jeong-Hun Ko, Antoni Olona, Adonia E. Papathanassiu, Norzawani Buang,  Kwon-Sik Park, Ana S. H. Costa, Claudio Mauro, Christian Frezza and Jacques Behmoaras. http://jcs.biologists.org/content/133/22/jcs247957?etoc
 
In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells – Wilson I. Gonsalves, Jin Sung Jang, Erik Jessen, Taro Hitosugi, Laura A. Evans, Dragan Jevremovic, Xuan-Mai Pettersson, Alexander Graham Bush, Jaimee Gransee, Emilie I. Anderson, Shaji K. Kumar and K. Sreekumaran Nair. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00235-4
 


Glucose metabolism


Increased demand for NAD+ relative to ATP drives aerobic glycolysis – Alba Luengo, Zhaoqi Li, Dan Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, Raphael Ferreira, Adi Naamati, Ahmed Ali, Caroline A. Lewis, Craig J. Thomas, Stefani Spranger, Nicholas J. Matheson, Matthew G. Vander Heiden. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30904-7
 
HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma – Ruixue Zhang, Mengqin Shen, Chunhua Wu, Yumei Chen, Jiani Lu, Jiajin Li, Li Zhao, Huannan Meng, Xiang Zhou, Gang Huang, Xiaoping Zhao and Jianjun Liu. https://www.nature.com/articles/s41419-020-03212-3
 


Lipid metabolism


A metastasis map of human cancer cell lines – Xin Jin, Zelalem Demere, Karthik Nair, Ahmed Ali, Gino B. Ferraro, Ted Natoli, Amy Deik, Lia Petronio, Andrew A. Tang, Cong Zhu, Li Wang, Danny Rosenberg, Vamsi Mangena, Jennifer Roth, Kwanghun Chung, Rakesh K. Jain, Clary B. Clish, Matthew G. Vander Heiden and Todd R. Golub. https://www.nature.com/articles/s41586-020-2969-2
 
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis – Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, and Xuejun Jiang. https://www.pnas.org/content/117/49/31189.abstract?etoc
 
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications – Youbo Zhao, Menghuan Li, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31476-5
 
Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance – Zi-Qi Zheng, Zhi-Xuan Li, Jia-Li Guan, Xu Liu, Jun-Yan Li, Yue Chen, Li Lin, Jia Kou, Jia-Wei Lv, Lu-Lu Zhang, Guan-Qun Zhou, Rui-Qi Liu, FoPing Chen, Xiao-Jun He, Ying-Qin Li, Feng Li, Si-Si Xu, Jun Ma, Na Liu and Ying Sun. https://cancerres.aacrjournals.org/content/80/23/5174

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses – Ryan Houston,Shiori Sekine,Michael J. Calderon,Fayaz Seifuddin,Guanghui Wang,Hiroyuki Kawagishi,Daniela A. Malide,Yuesheng Li,Marjan Gucek,Mehdi Pirooznia,Alissa J. Nelson,Matthew P. Stokes,Jacob Stewart-Ornstein,Steven J. Mullett,Stacy G. Wendell,Simon C. Watkins,Toren Finkel,Yusuke Sekine. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000981
 
KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL – Cody N. Rozeveld, Katherine M. Johnson, Lizhi Zhang and Gina L. Razidlo. https://cancerres.aacrjournals.org/content/80/22/4932

 

Nucleotides and folate



The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies – Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Dombret, Claude Preudhomme, Nina Fenouille, Lina Benajiba, Hava M. Golan, Kimberly Stegmaier, Camille Lobry, Kris C. Wood, Raphael Itzykson and Alexandre Puissant. https://cancerdiscovery.aacrjournals.org/content/10/12/1894
 
Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma – Jie Cai, Xuehua Sun, Han Guo, Xiaoye Qu, Hongting Huang, Chang Yu, Hailong Wu, Yueqiu Gao, Xiaoni Kong and Qiang Xia. https://www.nature.com/articles/s41389-020-00287-7

 

Mitochondria



Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability – Chen-Hua Chuang, Madeleine Dorsch, Philip Dujardin, Sukrit Silas, Kristina Ueffing, Johanna M Hölken, Dian Yang, Monte M Winslow  Barbara M Grüner. https://cancerres.aacrjournals.org/content/early/2020/11/25/0008-5472.CAN-20-1865
 
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import – Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri and Giulio Superti-Furga. https://www.nature.com/articles/s41467-020-19871-x
 
Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function – Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M. Bode and Zigang Dong. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00234-5

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study – Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM. https://www.nature.com/articles/s41418-020-00683-x
 


Starvation / Metabolic stress


Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate – Blake R. Wilde, Mohan R. Kaadige, Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm and Donald E. Ayer. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00233-6

PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability – Sandra M. Martín-Guerrero; Pedro Casado; Maruan Hijazi; Vinothini Rajeeve; Julio Plaza-Díaz; Francisco Abadía-Molina; Julio Navascués; Miguel A. Cuadros; Pedro R. Cutillas; David Martín-Oliva. https://portlandpress.com/biochemj/article-abstract/477/23/4491/226892

 

Hypoxia


Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types – Ana Miar, Esther Arnaiz, Esther Bridges, Shaunna Beedie, Adam P. Cribbs, Damien J. Downes, Robert A. Beagrie, Jan Rehwinkel and Adrian L. Harris. https://cancerres.aacrjournals.org/content/80/23/5245
 
 

IDH


Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment – Elavarasan Subramani, Marina Radoul, Chloe Najac, Georgios Batsios, Abigail R. Molloy, Donghyun Hong, Anne Marie Gillespie, Romelyn Delos Santos, Pavithra Viswanath, Joseph F. Costello, Russell O. Pieper and Sabrina M. Ronen. https://cancerres.aacrjournals.org/content/80/22
 
Inhibition of 2-Hydroxyglutarate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity in Mice – Padma Kadiyala, Stephen V. Carney, Jessica C. Gauss, Maria B. Garcia-Fabiani, Santiago Haase, Mahmoud S. Alghamri, Felipe J. Núñez, Yayuan Liu, Minzhi Yu, Ayman W. Taher, Fernando M. Nunez, Dan Li, Marta B. Edwards, Celina G. Kleer, Henry Appelman, Yilun Sun, Lili Zhao, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro. https://www.jci.org/articles/view/139542
 


Cancer Immunometabolism


Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity – Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker, Alessia  Catozzi, Juan C. García-Cañaveras, Brandon M. Gassaway, Brian C. Miller,  Vikram R. Juneja, Thao H. Nguyen, Shakchhi Joshi, Cong-Hui Yao, Haejin Yoon,  Peter T. Sage, Martin W. LaFleur, Justin D. Trombley, Connor A. Jacobson,  Zoltan Maliga, Steven P. Gygi, Peter K. Sorger, Joshua D. Rabinowitz, Arlene  H. Sharpe, Marcia C. Haigis. https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9
 
De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function – Ruohan Wu , Xuyong Chen, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Yufeng Yao, Lingling Liu, Gaofeng Fan, Mark R. Burns, Ruoning Wang. https://advances.sciencemag.org/content/6/51/eabc4275/tab-article-info
 
Lactate Limits T Cell Proliferation via the NAD(H) Redox State – William J. Quinn III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31489-3
 
The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies – Sruthy Varghese, Snigdha Pramanik, Leila J. Williams, Hannah R Hodges, Courtney W Hudgens, Grant M. Fischer, Catherine K Luo, Barbara Knighton, Lin Tan, Philip L. Lorenzi, Andrew L. MacKinnon, Jennifer L. McQuade, Yared Hailemichael, Jason Roszik, Weiyi Peng and Y.N. Vashisht Gopal. https://mct.aacrjournals.org/content/early/2020/12/23/1535-7163.MCT-20-0430.long
 


Miscellaneous


3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis – Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30693-6

The Associations of Aspirin, Statins, and Metformin With Lung Cancer Risk and Related Mortality: A Time-Dependent Analysis of Population-Based Nationally Representative Data – Jihun Kang, Su-Min Jeong, Dong Wook Shin, Mihee Cho, Jong Ho Cho, Jehun Kim. https://www.jto.org/article/S1556-0864(20)30712-7/fulltext
 


Reviews


Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy – Sarah-Maria Fendt, Christian Frezza and Ayelet Erez. https://cancerdiscovery.aacrjournals.org/content/10/12/1797

The Bidirectional Relationship Between Cancer Epigenetics and Metabolism – Luke T. Izzo, Hayley C. Affronti, and Kathryn E. Wellen. Annual Review of Cancer Biology. https://www.annualreviews.org/doi/abs/10.1146/annurev-cancerbio-070820-035832

Crosstalk between mechanotransduction and metabolism – Patrizia Romani, Lorea Valcarcel-Jimenez, Christian Frezza and Sirio Dupont. https://www.nature.com/articles/s41580-020-00306-w

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases – Sanjeethan C. Baksh, Lydia W.S. Finley. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30190-2

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance – Belisario, D.C.; Kopecka, J.; Pasino, M.; Akman, M.; De Smaele, E.; Donadelli, M.; Riganti, C. https://www.mdpi.com/2073-4409/9/12/2598

The Metabolic Underpinnings of Ferroptosis – Jiashuo Zheng, Marcus Conrad. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30544-1

Iron: An Essential Element of Cancer Metabolism – Myriam Y. Hsu, Erica Mina, Antonella Roetto and Paolo E. Porporato. https://www.mdpi.com/2073-4409/9/12/2591

Fructose Metabolism in Cancer – Nils Krause and Andre Wegner. https://www.mdpi.com/2073-4409/9/12/2635

The p53 Pathway and Metabolism: The Tree That Hides the Forest – Airelle Lahalle, Matthieu Lacroix, Carlo De Blasio, Madi Y. Cissé, Laetitia K. Linaresand Laurent Le Cam. https://www.mdpi.com/2072-6694/13/1/133#abstract
 


Comments


Fighting for Fat: Gluttonous Tumors and Starved T Cells – Joshua H. Goodman, Anthony W. Ferrante Jr. https://www.cell.com/cell/fulltext/S0092-8674(20)31611-1

Mind your media – Shoval Lagziel, Eyal Gottlieb and Tomer Shlomi. https://www.nature.com/articles/s42255-020-00299-y

Tumor start‐up: mitochondrial fusion makes it happen – Ana R Rebelo, Marcia Garcez, Catarina CF Homem. https://www.embopress.org/doi/abs/10.15252/embj.2020106927

O-Mg! Lactate Drives Mg2+ Mobilization – Blake R. Wilde, Heather R. Christofk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30801-7

The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension – Warren L. Wu, Thales Papagiannakopoulos. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30800-5

One Metformin a Day, Keeps Lung Cancer Away! Or Does It? – Samira Shojaee, Patrick Nana-Sinkam. https://www.jto.org/article/S1556-0864(20)30811-X/fulltext

Neutrophils Provide Lipids to Metastatic Tumor Cells, Fueling Growthhttps://cancerdiscovery.aacrjournals.org/content/10/12/OF9

MetaboList – November 2020


Starvation/metabolism and translation


Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer – Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schneider, Michael E. Pacold, Alec C. Kimmelman. https://www.cell.com/cell/fulltext/S0092-8674(20)31322-2

Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors – Stefan Bresson, Vadim Shchepachev, Christos Spanos, Tomasz W. Turowski, Juri Rappsilber, David Tollervey. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30651-1

A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress – Adam M. Lamper, Rebecca H. Fleming, Kayla M. Ladd, Amy S. Y. Lee. https://science.sciencemag.org/content/370/6518/853

A translational program that suppresses metabolism to shield the genome – Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz and Stephen Lee. https://www.nature.com/articles/s41467-020-19602-2

eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis – Ruan H, Li X, Xu X, Leibowitz BJ, Tong J, Chen L, Ao L, Xing W, Luo J, Yu Y, Schoen RE, Sonenberg N, Lu X, Zhang L, Yu J. https://elifesciences.org/articles/60151

4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs – Khawla Alasad, Kai Voeltzke, Liron Levin, Guido Reifenberger, Gabriel Leprivier and Barak Rotblat. https://www.nature.com/articles/s41419-020-03182-6


Amino acid metabolism


Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway – Ian J. Restall, Orsolya Cseh, Laura M. Richards, Trevor J. Pugh, H. Artee Luchman and Samuel Weiss. https://cancerres.aacrjournals.org/content/early/2020/10/24/0008-5472.CAN-19-3923.long

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis – Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler and Juliane G. Bogner-Strauss. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00232-7

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity – Amani Bouzidi, Maria Chiara Magnifico, Alessandro Paiardini, Alberto Macone, Giovanna Boumis, Giorgio Giardina, Serena Rinaldo, Francesca Romana Liberati, Clotilde Lauro, Cristina Limatola, Chiara Lanzillotta, Antonella Tramutola, Marzia Perluigi, Gianluca Sgarbi, Giancarlo Solaini, Alessandra Baracca, Alessio Paone and Francesca Cutruzzolà. https://www.nature.com/articles/s41419-020-03215-0

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers – Yiqing Zhao, Xiujing Feng, Yicheng Chen, J. Eva Selfridge, Shashank Gorityala, Zhanwen Du, Janet M. Wang, Yujun Hao, Gino Cioffi, Ronald A. Conlon, Jill S. Barnholtz-Sloan, Joel Saltzman, Smitha S. Krishnamurthi, Shaveta Vinayak, Martina Veigl, Yan Xu, David L. Bajor, Sanford D. Markowitz, Neal J. Meropol, Jennifer R. Eads and Zhenghe Wang. https://cancerres.aacrjournals.org/content/80/21/4815


Glycolysis, glucosamines


The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer – Jiyeon Kim, Hyun Min Lee, Feng Cai, Bookyung Ko, Chendong Yang, Elizabeth L. Lieu, Nefertiti Muhammad, Shawn Rhyne, Kailong Li, Mohamed Haloul, Wen Gu, Brandon Faubert, Akash K. Kaushik, Ling Cai, Sahba Kasiri, Ummay Marriam, Kien Nham, Luc Girard, Hui Wang, Xiankai Sun, James Kim, John D. Minna, Keziban Unsal-Kacmaz and Ralph J. DeBerardinis. https://www.nature.com/articles/s42255-020-00316-0

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers – Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Victoria C. Yan, Yasaman Barekatain, Sunada Khadka, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Cong-Dat Pham, Kenisha Arthur, David Maxwell, Zhenghong Peng, Paul G. Leonard, Barbara Czako, Federica Pisaneschi, Pijus Mandal, Yuting Sun, Rafal Zielinski, Susana Castro Pando, Xiaobo Wang, Theresa Tran, Quanyu Xu, Qi Wu, Yongying Jiang, Zhijun Kang, John M. Asara, Waldemar Priebe, William Bornmann, Joseph R. Marszalek, Ronald A. DePinho and Florian L. Muller. https://www.nature.com/articles/s42255-020-00313-3

Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target – Juliana C. Ferreira, Abdul-Rahman Khrbtli, Cameron Lee Shetler, Samman Mansoor, Liaqat Ali, Ozge Sensoy and Wael M. Rabeh. http://www.jbc.org/content/early/2020/11/13/jbc.RA120.015293.abstract

Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis – Keqiu Jiang, Chengyong Dong, Zeli Yin, Rui Li, Jiakai Mao, Chengye Wang, Junlin Zhang, Zhenming Gao, Rui Liang, Qi Wang and Liming Wang. https://www.nature.com/articles/s41419-020-03179-1


Lipid metabolism


Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis – Jonathan S. Rink, Adam Lin, Kaylin M. McMahon, Andrea E Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton and Leo I Gordon. http://www.jbc.org/content/early/2020/11/18/jbc.RA120.014888.abstract

ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway – Guohua Chen, Guoli Zhou, Aaron Lotvola, James G. Granneman and Jian Wang. http://www.jbc.org/content/early/2020/11/20/jbc.RA120.014682.abstract

The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial – Maria Feldt, Julien Menard, Ann H. Rosendahl, Barbara Lettiero, Pär-Ola Bendahl, Mattias Belting and Signe Borgquist. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00231-8


Mitochondria and mitochondrial stress


MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity – Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa and Masatoshi Nomura. https://www.nature.com/articles/s41467-020-19287-7

Anti-cancer strategy targeting the energy metabolism of tumor cells surviving a low-nutrient acidic microenvironment – Yuki Maeda, Ryota Kikuchi, Junichiro Kawagoe, Takao Tsuji, Nobuyuki Koyama, Kazuhiro Yamaguchi, Hiroyuki Nakamura, Kazutetsu Aoshiba. https://www.sciencedirect.com/science/article/pii/S2212877820301678


Starvation / nutrient sensing


Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation – Chan Lee, Lilian Lamech, Eleanor Johns, Michael Overholtzer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30666-3

Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress – Huaiyuan Zhang, Yu Zhao, Qi Yao, Zijing Ye, Adriana Mañas, Jialing Xiang. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242700

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity – Yao Yao, Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A. MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30687-0

Rapid changes in the ATG5‐ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT) – Emily Crowley  Euphemia Leung  Jóhannes Reynisson  Alan Richardson. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15275


mTOR / AMPK


The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction – Shu Yang, Yingbiao Zhang, Chun-Yuan Ting, Lucia Bettedi, Kuikwon Kim, Elena Ghaniam, Mary A. Lilly. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30630-4

IQGAP1 binds AMPK and is required for maximum AMPK activation – Andrew C. Hedman, Zhigang Li, Laëtitia Gorisse, Swetha Parvathaneni, Chase J. Morgan and David B. Sacks. http://www.jbc.org/content/early/2020/11/15/jbc.RA120.016193.abstract


Hypoxia


p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen – Liz J. Valente; Amy Tarangelo; Albert Mao Li ; Marwan Naciri; Nitin Raj; Anthony M. Boutelle; Yang Li; Stephano Spano Mello ; Kathryn Bieging-Rolett; Ralph J. DeBerardinis; Jiangbin Ye; Scott J. Dixon; Laura D. Attardi. https://rupress.org/jcb/article/219/11/e201908212/152074

LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α – Linguo Xu, Lin Huan, Tianan Guo, Yangjun Wu, Yanfang Liu, Qifeng Wang, Shenglin Huang, Ye Xu, Linhui Liang and Xianghuo He. https://www.nature.com/articles/s41388-020-01512-8


Cancer Immunometabolism


Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity – Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30722-X

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy – Meixi Hao, Siyuan Hou, Weishuo Li, Kaiming Li, Lingjing Xue, Qifan Hu, Lulu Zhu, Yue Chen, Hongbin Sun, Caoyun Ju, Can Zhang. https://stm.sciencemag.org/content/12/571/eaaz6667

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy – Chia-Sing Lu, Ching-Wen Lin, Ya-Hsuan Chang, Hsuan-Yu Chen, Wei-Chia Chung2, Wei-Yun Lai, Chao-Chi Ho, Tong-Hong Wang, Chi-Yuan Chen, Chen-Lin Yeh, Sean Wu, Shu-Ping Wang and Pan-Chyr Yang. https://jitc.bmj.com/content/8/2/e001392


Miscellaneous


Treatment of glioblastoma multiforme with “classic” 4:1 ketogenic diet total meal replacement – Pavel Klein, Ivana Tyrlikova, Giulio Zuccoli, Adam Tyrlik and Joseph C. Maroon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00230-9

Downregulation of Keap1 Confers Features of a Fasted Metabolic State – Elena V Knatko, Michael H Tatham, Ying Zhang, Cecilia Castro, Maureen Higgins, Sharadha Dayalan Naidu, Chiara Leonardi, Laureano de la Vega, Tadashi Honda, Julian L Griffin, Ronald T Hay, Albena T Dinkova-Kostova. https://www.cell.com/iscience/fulltext/S2589-0042(20)30830-0


Reviews


Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy – Weimin Wang, Weiping Zou. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30614-6

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer – DeBlasi JM, DeNicola GM. https://pubmed.ncbi.nlm.nih.gov/33080927/

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment – Lara P. Fernández, Marta Gómez de Cedrón, and Ana Ramírez de Molina. https://www.frontiersin.org/articles/10.3389/fonc.2020.577420/full

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation – Tashbib Khan, Mitchell A. Sullivan, Jennifer H. Gunter, Thomas Kryza, Nicholas Lyons, Yaowu He, and John D. Hooper. https://www.frontiersin.org/articles/10.3389/fonc.2020.592455/full

Metabolic heterogeneity in cancer: An overview and therapeutic implications – Yu Tong, Wei-Qiang Gao, Yanfeng Liu. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20301402

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors – Marjolein M.G. Kes, Jan Van den Bossche, Arjan W. Griffioen, Elisabeth J.M. Huijbers. https://www.sciencedirect.com/science/article/pii/S0304419X20301463

2-Oxoglutarate-dependent dioxygenases in cancer – Julie-Aurore Losman, Peppi Koivunen and William G. Kaelin Jr. https://www.nature.com/articles/s41568-020-00303-3

A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer – Kodama M, Nakayama KI.. https://onlinelibrary.wiley.com/doi/10.1002/bies.202000169

Current biomarker-associated procedures of cancer modeling-a reference in the context of IDH1 mutant glioma – Narges Zare Mehrjardi, Daniel Hänggi and Ulf Dietrich Kahlert. https://www.nature.com/articles/s41419-020-03196-0

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy – Michaël Cerezo and Stéphane Rocchi. https://www.nature.com/articles/s41419-020-03175-5


Comments


A Tug-of-War Over Methionine – Ke Xu, Amy Shyu, Ming O. Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30549-0

Aldolase deployed for surveilling glucose – Sheng-Cai Lin. https://www.nature.com/articles/s41580-020-00305-x

Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux – Maria I. Matias, Valérie Dardalhon, Naomi Taylor. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30783-8

The metabolic foibles of triple negative breast cancer – Emily J. Gallagher. https://stm.sciencemag.org/content/12/571/eabf7102

In PDAC, “bad” cholesterol is good – Leslie K. Ferrarelli. https://stke.sciencemag.org/content/13/657/eabf5642

Metabolic benefits of mitochondrial DNA mutations – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-00309-x

Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming – Ana M.Urbano. https://www.sciencedirect.com/science/article/pii/S0925443920303136

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The 4th edition of Cancer and Metabolism symposium – Bordeaux area, France, May 27-29th 2021 will address key questions on human tumors nutrition and metabolism. Special guest: Sir Peter J. Ratcliffe, Nobel co-Laureate in 2019. http://www.canceropole-gso.org/?p=calendrier&id=1905&mod=evenement_consulter

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For more weekly updates on papers on Glutamine metabolism follow  Sreeparna Banerjee (https://twitter.com/sreeparna_b)

For more weekly papers on mitochondrial bioenergetics and cancer follow Kelsey Fisher-Wellman (https://twitter.com/KFW_Lab) (and @Frezzalab of course)