MetaboList – June 2022


Nutrient sensing – mTOR


Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine – Andrew L. Cangelosi, Anna M. Puszynska, Justin M. Roberts, Andrea Armani, Thao P. Nguyen, Jessica B. Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A. Lewis, William C. Comb, George W. Bell, Aharon Helman, David M. Sabatini. https://www.science.org/doi/abs/10.1126/science.abi9547

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1 – Gwen R. Buel, Huy Q. Dang, John M. Asara, John Blenis, Anders P. Mutvei. https://www.jbc.org/article/S0021-9258(22)00470-7/fulltext

Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation – Hongrui Xiang, Yuexiao Tao, Zhenyan Jiang, Xian Huang, Huizi Wang, Wei Cao, Jia Li, Rui Ding, Mingyi Shen, Ru Feng, Linsen Li, Chenyang Guan, Jiamin Liu, Jun Ni, Lei Chen, Zhengting Wang, Youqiong Ye, Qing Zhong, Junling Liu, Qiang Zou, Xuefeng Wu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00725-2


Nutrient sensing – ISR


A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression – Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, J. Alan Diehl, Serge Y. Fuchs, Ellen Puré and Constantinos Koumenis. https://www.nature.com/articles/s41556-022-00918-8

Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific – Jonsson WO, Mirek ET, Wek RC, Anthony TG. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202200204RR

Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response – Aleksandra P Pitera, Maria Szaruga, Sew-Yeu Peak-Chew, Steven W Wingett, Anne Bertolotti. https://www.embopress.org/doi/full/10.15252/embj.2021109985


Nutrient sensing: AMPK


A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis – Hsing-I Tseng, Yi-Siang Zeng, Ying-Chung Jimmy Lin, Jui-Wen Huang, Chih-Lung Lin, Meng-Hsuan Lee, Fan-Wei Yang, Te-Ping Fang, Ai-Chung Mar, Jung-Chen Su. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13211

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator – Ashley J. Ovens, Yi Sing Gee, Naomi X.Y. Ling, Dingyi Yu, Justin P. Hardee, Jin D. Chung; Kevin R.W. Ngoei, Nicholas J. Waters, Nolan J. Hoffman, John W. Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W. Parker, Gordon S. Lynch, Fei Huang, Sandra Galic, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill, Christopher G. Langendorf. https://portlandpress.com/biochemj/article/479/11/1181/231304

Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation – Shijie Ma, Zizheng Dong, Yanfei Huang, Jing-Yuan Liu, Jian-Ting Zhang. https://www.jbc.org/article/S0021-9258(22)00484-7/fulltext


Nutrient sensing – miscellaneous


The polyol pathway is an evolutionarily conserved system for sensing glucose uptake – Hiroko Sano, Akira Nakamura, Mariko Yamane, Hitoshi Niwa, Takashi Nishimura, Kimi Araki, Kazumasa Takemoto, Kei-ichiro Ishiguro, Hiroki Aoki, Yuzuru Kato, Masayasu Kojima. https://www.nature.com/articles/s42255-022-00568-y

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth – Chunming Cheng, Feng Geng, Zoe Li, Yaogang Zhong, Huabao Wang, Xiang Cheng, Yue Zhao, Xiaokui Mo, Craig Horbinski, Wenrui Duan, Arnab Chakravarti, Xiaolin Cheng and Deliang Guo. https://www.nature.com/articles/s42255-022-00568-y

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors – Melvin Pan, Christiane Zorbas and Tsuyoshi Osawa. https://www.nature.com/articles/s41467-022-31418-w

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth – Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso and Michael Potente. https://www.nature.com/articles/s42255-022-00584-y


Hypoxia


Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia – Javier Garcia-Bermudez, Michael A. Badgley, Sheela Prasad, Lou Baudrier, Yuyang Liu, Konnor La, Mariluz Soula, Robert T. Williams, Norihiro Yamaguchi, Rosa F. Hwang, Laura J. Taylor, Elisa de Stanchina, Bety Rostandy, Hanan Alwaseem, Henrik Molina, Dafna Bar-Sagi and Kıvanç Birsoy. https://www.nature.com/articles/s42255-022-00583-z

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome – Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sörensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao and Susanne Schlisio. https://www.nature.com/articles/s42255-022-00593-x

Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a non-canonical mechanism – Hideaki Nakamura, Hiroki Sekine, Hiroyuki Kato, Hisao Masai, Katarina Gradin, Lorenz Poellinger. https://www.jbc.org/article/S0021-9258(22)00579-8/fulltext


Glucose metabolism


G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment – Shree Bose, Qiang Huang, Yunhan Ma, Lihua Wang, Grecia O. Rivera, Yunxin Ouyang, Regina Whitaker, Rebecca A. Gibson, Christopher D. Kontos, Andrew Berchuck, Rebecca A. Previs, Xiling Shen. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00801-4

A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect – Xuejun Wen; Changrong Shi;, Xinying Zeng, Liang Zhao, Lanlin Yao, Zhida Liu, Lixia Feng, Deliang Zhang, Jinxiong Huang, Yesen Li, Qin Lin, Haojun Chen, Rongqiang Zhuang, Xiaoyuan Chen,  Xianzhong Zhang, Zhide Guo. https://aacrjournals.org/clincancerres/article-abstract/28/13/2923/704989

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness – Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick and Aaron D. Schimmer. https://www.nature.com/articles/s41556-022-00925-9


Amino acid metabolism


Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix – Emily J. Kay, Karla Paterson, Carla Riero-Domingo, David Sumpton, J. Henry M. Däbritz, Saverio Tardito, Claudia Boldrini, Juan R. Hernandez-Fernaud, Dimitris Athineos, Sandeep Dhayade, Ekaterina Stepanova, Enio Gjerga, Lisa J. Neilson, Sergio Lilla, Ann Hedley, Grigorios Koulouras, Grace McGregor, Craig Jamieson, Radia Marie Johnson, Morag Park, Kristina Kirschner, Crispin Miller, Jurre J. Kamphorst, Fabricio Loayza-Puch, Julio Saez-Rodriguez, Massimiliano Mazzone, Karen Blyth, Michele Zagnoni and Sara Zanivan. https://www.nature.com/articles/s42255-022-00582-0

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer – Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang. https://aacrjournals.org/cancerres/article-abstract/82/12/2254/699357

Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family – Natasha Freidman, Chelsea Briot, Renae Ryan. https://www.jbc.org/article/S0021-9258(22)00620-2

mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine – Mahabub Alam, Hiroki Shima, Yoshitaka Matsuo, Nguyen Chi Long, Mitsuyo Matsumoto, Yusho Ishii, Nichika Sato, Takato Sugiyama, Risa Nobuta, Satoshi Hashimoto, Liang Liu, Mika K. Kaneko, Yukinari Kato, Toshifumi Inada, Kazuhiko Igarashi. https://www.jbc.org/article/S0021-9258(22)00525-7/fulltext

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML – Chang Liu, Waiyi Zou, Danian Nie, Shuyi Li, Chen Duan, Min Zhou, Peilong Lai, Shengyong Yang, Sen Ji, Yangqiu Li, Mei Mei, Shilai Bao, Yanli Jin, Jingxuan Pan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00131-0

Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response – Dong-Jing Cai, Zi-Yu Zhang, Yue Bu, Li Li, Yue-Zhen Deng, Lun-Quan Sun, Cheng-Ping Hu and Min Li. https://www.nature.com/articles/s41419-022-05015-0


Lipid metabolism


Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited – Zhaoqi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios, Keene L. Abbott, Justine C. Rutter, Anna M. Westermark, Elizabeth F. Gorodetsky, Lucas B. Sullivan, Matthew G. Vander Heiden and Dennis Vitkup. https://www.nature.com/articles/s42255-022-00588-8

The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition – Junfang Lyu, Mehdi Pirooznia, Yuesheng Li, and Jianhua Xiong. https://www.molbiolcell.org/doi/10.1091/mbc.E22-02-0066?ai=s5&ui=2oy6&af=T

Ct-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation – Yutang Huang, Yan Du, Yujie Zheng, Chunjie Wen, Hecun Zou, Jiafeng Huang, Honghao Zhou, Hongbo Zhao and Lanxiang Wu. https://www.nature.com/articles/s41419-022-05014-1

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma – Ling Tao, Mahmoud A. Mohammad and Eveline Barbieri. https://www.nature.com/articles/s41467-022-31331-2


Mitochondria and iron


NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins – Naiara Santana-Codina, Maria Quiles del Rey, Kevin S. Kapner, Huan Zhang, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen M. John, Douglas E. Biancur, Brandon Chen, Nupur K. Das, Kristen E. Lowder, Connor J. Hennessey, Wesley Huang, Annan Yang, Yatrik M. Shah, Jonathan A. Nowak, Andrew J. Aguirre, Joseph D. Mancias. https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0043/704854

Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer – Mirunalini Ravichandran, Jingjie Hu, Charles Cai, Nathan P. Ward, Anthony Venida, Callum Foakes, Miljan Kuljanin, Annan Yang, Connor J. Hennessey, Yang Yang, Brandon R. Desousa, Gilles Rademaker, Annelot A.L. Staes, Zeynep Cakir, Isha H. Jain, Andrew J. Aguirre, Joseph D. Mancias, Yin Shen, Gina M. DeNicola, Rushika M. Perera. https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-22-0044/706733

Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila – Shamsi Emtenani, Elliot T Martin, Attila Gyoergy, Julia Bicher, Jakob-Wendelin Genger, Thomas Köcher, Maria Akhmanova, Mariana Guarda, Marko Roblek, Andreas Bergthaler, Thomas R Hurd, Prashanth Rangan, Daria E Siekhaus. https://www.embopress.org/doi/full/10.15252/embj.2021109049


Cancer Immunometabolism


Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics – Qi Liu, Fangming Zhu, Xinnan Liu, Ying Lu, Ke Yao, Na Tian, Lingfeng Tong, David A. Figge, Xiuwen Wang, Yichao Han, Yakui Li, Yemin Zhu, Lei Hu, Yingning Ji, Nannan Xu, Dan Li, Xiaochuan Gu, Rui Liang, Guifang Gan, Lifang Wu, Ping Zhang, Tianle Xu, Hui Hu, Zeping Hu, Huji Xu, Dan Ye, Hui Yang, Bin Li and Xuemei Tong. https://www.nature.com/articles/s42255-022-00575-z

Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion – Zhiqiang Wang, Zhou Lu, Shengli Lin, Jie Xia, Ziwen Zhong, Zhangjuan Xie, Yun Xing, Jingbo Qie, Mengxia Jiao, Yifan Li, Haoyu Wen, Pengyuan Zhao, Dan Zhang, Pinghong Zhou, Jiawen Qian, Feifei Luo, Luman Wang, Hongxiu Yu, Jie Liu, Jie Gu, Ronghua Liu, Yiwei Chu. https://www.cell.com/immunity/fulltext/S1074-7613(22)00188-1

Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4+ T-cell proliferation and glycolytic activity under hypoxia and normoxia – Jonas A. Wik, Azazul Chowdhury, Shrikant Kolan, Nasser E. Bastani, Gaoyang Li, Kazi Alam, Franco Grimolizzi, Bjørn S. Skålhegg. https://portlandpress.com/biochemj/article/479/11/1221/231349

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells – Jian Gu, Jinren Zhou, Qiuyang Chen, Xiaozhang Xu, Ji Gao, Xiangyu Li, Qing Shao, Bo Zhou, Haoming Zhou, Song Wei, Qi Wang, Yuan Liang, Ling Lu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00772-0


Miscellaneous


Metformin-induced reductions in tumor growth involves modulation of the gut microbiome – Lindsay A. Broadfield, Amna Saigal, Jake C. Szamosi, Joanne A. Hammill, Ksenia Bezverbnaya, Dongdong Wang, Jaya Gautam, Evangelia E. Tsakiridis, Fiorella Di Pastena, Jamie McNicol, Jianhan Wu, Saad Syed, James S.V. Lally, Amogelang R. Raphenya, Marie-Jose Blouin, Michael Pollak, Andrea Sacconi, Giovanni Blandino, Andrew G. McArthur, Jonathan D. Schertzer. https://www.sciencedirect.com/science/article/pii/S2212877822000679

An exercise-inducible metabolite that suppresses feeding and obesity – Veronica L. Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T. Kim, Amanda L. Wiggenhorn, Julia T. Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H. Zushin, Robert S. Jansen, Basil Michael, Kang Yong Loh, Andrew C. Yang, Christian S. Carl, Christian T. Voldstedlund, Wei Wei, Stephanie M. Terrell, Benjamin C. Moeller, Rick M. Arthur, Gareth A. Wallis, Koen van de Wetering, Andreas Stahl, Bente Kiens, Erik A. Richter, Steven M. Banik, Michael P. Snyder, Yong Xu and Jonathan Z. Long. https://www.nature.com/articles/s41586-022-04828-5


Reviews


Ribosome biogenesis and the cellular energy economy – David Shore, Benjamin Albert. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00719-9

Ferroptosis at the intersection of lipid metabolism and cellular signaling – Deguang Liang, Alexander M. Minikes, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00260-X

Shaping fuel utilization by mitochondria – Lukas Alan, Luca Scorrano. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00765-5

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities – Balaraman Kalyanaraman, Gang Cheng, Micael Hardy. https://www.frontiersin.org/articles/10.3389/fonc.2022.816504/full

Fatty acid synthase: a druggable driver of breast cancer brain metastasis – Javier A. Menendez and Ruth Lupu. https://www.tandfonline.com/doi/full/10.1080/14728222.2022.2077189


Comments


NAD+ regeneration drives cancer cell proliferation – Xu Han and M. Celeste Simon. https://www.nature.com/articles/s42255-022-00579-9

YAP/TAZ–TEAD link angiogenesis to nutrients – Roxana E. Oberkersch and Massimo M. Santoro. https://www.nature.com/articles/s42255-022-00579-9

TCA cycle off, ATF4 on for metabolic homeostasis – Durga Mahor, Rishikesh Pandey, Vinay Bulusu. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(22)00065-2

Research is a process – Sarah-Maria Fendt. https://www.nature.com/articles/s41556-022-00954-4

MetaboList – May 2022


Nucleotides / one carbon


Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway – Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra and Gerta Hoxhaj. https://www.nature.com/articles/s41467-022-30362-z

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells – Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis. https://www.science.org/doi/full/10.1126/sciadv.abm8786

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis – Nicole Kiweler, Catherine Delbrouck, Vitaly I. Pozdeev, Laura Neises, Leticia Soriano-Baguet, Kim Eiden, Feng Xian, Mohaned Benzarti, Lara Haase, Eric Koncina, Maryse Schmoetten, Christian Jaeger, Muhammad Zaeem Noman, Alexei Vazquez, Bassam Janji, Gunnar Dittmar, Dirk Brenner, Elisabeth Letellier and Johannes Meiser. https://www.nature.com/articles/s41467-022-30363-y

CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer – G. Filippone, D. Gaglio, R. Bonfanti, F. A. Tucci, E. Ceccacci, R. Pennisi, M. Bonanomi, G. Jodice, M. Tillhon, F. Montani, G. Bertalot, S. Freddi, M. Vecchi, A. Taglialatela, M. Romanenghi, F. Romeo, N. Bianco, E. Munzone, F. Sanguedolce, G. Vago, G. Viale, P. P. Di Fiore, S. Minucci, L. Alberghina, M. Colleoni, P. Veronesi, D. Tosoni and S. Pece. https://www.nature.com/articles/s41467-022-30375-8


Mitochondria / IDH


Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia – Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Bernard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas and Richard J. D’Andrea. https://www.nature.com/articles/s41467-022-30223-9

IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system – Anjaneyulu Murari, Naga S. V. Goparaju, Shauna-Kay Rhooms, Kaniz F. B. Hossain, Felix G. Liang, Christian J. Garcia, Cindy Osei, Tong Liu, Hong Li, Richard N. Kitsis, Rajesh Patel, Edward Owusu-Ansah. https://www.science.org/doi/full/10.1126/sciadv.abl8716

Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer – Monica De Luise, Manuela Sollazzo, Eleonora Lama, Camelia Alexandra Coadă, Licia Bressi, Maria Iorio, Beatrice Cavina, Luigi D’Angelo, Sara Milioni, Lorena Marchio, Stefano Miglietta, Sara Coluccelli, Greta Tedesco, Anna Ghelli, Silvia Lemma, Anna Myriam Perrone, Ivana Kurelac, Luisa Iommarini, Anna Maria Porcelli and Giuseppe Gasparre. https://www.nature.com/articles/s41598-022-11620-y

Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment – Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan and Dipayan Chaudhuri. https://www.nature.com/articles/s41467-022-30236-4

OXPHOS deficiencies affect peroxisome proliferation by downregulating genes controlled by the SNF1 signaling pathway [yeast] – Jean-Claude Farre , Krypton Carolino, Lou Devanneaux, Suresh Subramani. https://elifesciences.org/articles/75143

Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy – Laura Torresano, Fulvio Santacatterina, Sonia Domínguez-Zorita, Cristina Nuevo-Tapioles, Alfonso Núñez-Salgado, Pau B. Esparza-Moltó, Lucía González-Llorente, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Brenda Sánchez-Garrido, Laura Nájera, Clara Salas, Mariano Provencio and José M. Cuezva. https://www.nature.com/articles/s41389-022-00400-y

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia – Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang and Marina Konopleva. https://www.nature.com/articles/s41467-022-30396-3


Glucose metabolism


PHGDH heterogeneity potentiates cancer cell dissemination and metastasis – Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grünewald, Morag Park, Jacco van Rheenen and Sarah-Maria Fendt. https://www.nature.com/articles/s41586-022-04758-2

The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity – Helena Dragic, Audrey Barthelaix, VCédric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugière, Yohann Couté, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Verge N Manié. https://www.life-science-alliance.org/content/5/7/e202101334

TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression – Inês Baptista, Effrosyni Karakitsou, Jean-Baptiste Cazier, Ulrich L Günther, Silvia Marin, Marta Cascante. https://www.mdpi.com/1422-0067/23/7/3574

The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62 – Juan F. Linares, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Anxo Martinez-Ordoñez, Miguel Reina-Campos, Hui-Hsuan Kuo, Olivier Elemento, M. Laura Martin, Thekla Cordes, Timothy C. Thompson, Christian M. Metallo, Jorge Moscat, Maria T. Diaz-Meco. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00559-9

Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines – Tia R. Tidwell, Gro V. Røsland, Karl Johan Tronstad, Kjetil Søreide and Hanne R. Hagland. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00285-w

Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF–ERK1/2 signaling pathways – Miji Jeon, Krishna M. Chauhan, Gregory L. Szeto, Minjoung Kyoung, Songon An. https://www.jbc.org/article/S0021-9258(22)00115-6/fulltext

Molecular basis for inhibiting human glucose transporters by exofacial inhibitors – Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang and Nieng Yan. https://www.nature.com/articles/s41467-022-30326-3


Amino acids


Cysteine is a limiting factor for glioma proliferation and survival – Victor Ruiz-Rodado, Tyrone Dowdy, Adrian Lita, Tamalee Kramp, Meili Zhang, Jinkyu Jung, Ana Dios-Esponera, Lumin Zhang, Christel C. Herold-Mende, Kevin Camphausen, Mark R. Gilbert, Mioara Larion. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13148

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome – Brian J. Golbourn, Matthew E. Halbert, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E. Mbah, Nisha Kabir, Ann-Catherine J. Stanton, Abigail L. Locke, Stephanie M. Casillo, Yanhua Zhao, Lauren M. Sanders, Allison Cheney, Steven J. Mullett, Apeng Chen, Michelle Wassell, Anthony Andren, Jennifer Perez, Esther P. Jane, Daniel R. David Premkumar, Robert F. Koncar, Shideh Mirhadi, Lauren H. McCarl, Yue-Fang Chang, Yijen L. Wu, Taylor A. Gatesman, Andrea F. Cruz, Michal Zapotocky, Baoli Hu, Gary Kohanbash, Xiuxing Wang, Alenoush Vartanian, Michael F. Moran, Frank Lieberman, Nduka M. Amankulor, Stacy G. Wendell, Olena M. Vaske, Ashok Panigrahy, James Felker, Kelsey C. Bertrand, Claudia L. Kleinman, Jeremy N. Rich, Robert M. Friedlander, Alberto Broniscer, Costas Lyssiotis, Nada Jabado, Ian F. Pollack, Stephen C. Mack and Sameer Agnihotri. https://www.nature.com/articles/s43018-022-00348-3

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis – Bin Jiang, Jia Zhang, Guohui Zhao, Mengjue Liu, Jielu Hu, Furong Lin, Jinyang Wang, Wentao Zhao, Huanhuan Ma, Cixiong Zhang, Caiming Wu, Luming Yao, Qingfeng Liu, Xin Chen, Yating Cao, Yi Zheng, Chensong Zhang, Aidong Han, Donghai Lin, Qinxi Li. https://www.sciencedirect.com/science/article/abs/pii/S1097276522002544?via%3Dihub

Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model – Koichi Azuma, Huihui Xiang, Tomoyuki Tagami et al. https://jitc.bmj.com/content/10/5/e004420

Cytosolic aspartate aminotransferase moonlights as a ribosome binding modulator of Gcn2 activity during oxidative stress – Robert A Crawford, Mark Peter Ashe, Simon J Hubbard, Graham D Pavitt. https://elifesciences.org/articles/73466


Lipid metabolism


Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer – Chenchen Guo, Ruijie Wan, Yayi He, Shu-Hai Lin, Jiayu Cao, Ying Qiu, Tengfei Zhang, Qiqi Zhao, Yujia Niu, Yujuan Jin, Hsin-Yi Huang, Xue Wang, Li Tan, Roman K. Thomas, Hua Zhang, Luonan Chen, Kwok-Kin Wong, Liang Hu and Hongbin Ji. https://www.nature.com/articles/s43018-022-00358-1

27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis – Xingkai Li, Hengchi Chen, Lizhen Zhang, Li Chen, Wei Wei, Shugeng Gao, Qi Xue, Yue Li, Bing Wang, Jiagen Li, Yushun Gao and Yanliang Lin. https://www.nature.com/articles/s41388-022-02285-y

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy – Smitha Pillai, Iqbal Mahmud, Rohit Mahar, Crystal Griffith, Michael Langsen, Jonathan Nguyen, Jonathan W. Wojtkowiak, Pawel Swietach, Robert A. Gatenby, Marilyn M. Bui, Matthew E. Merritt, Patricia McDonald, Timothy J. Garrett, Robert J. Gillies. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00569-1

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis – Qiqiao Du, Pan Liu, Chunyu Zhang, Tianyu Liu, Wei Wang, Chunliang Shang, Jieyu Wu, Yuandong Liao, Yili Chen, Jiaming Huang, Hao Tan, Yunhe Zhao, Meng Xia, Junxiu Liu and Shuzhong Yao. https://www.nature.com/articles/s41419-022-04926-2

Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids – Yi-Jia Li, Johannes Francois Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, Satyendra C. Tripathi, Chunyan Zhang, Yuan Yuan, David Ann, Samir Hanash, Hua Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00645-3

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling – Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina González-Estévez, Christian Kosan, Aleš Svatoš, Marcel Kwiatkowski and Andreas Koeberle. https://www.nature.com/articles/s41467-022-30374-9

Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients – Yogesh M. Bramhecha, Karl-Philippe Guérard, Étienne Audet-Walsh, Shaghayegh Rouzbeh, Ola Kassem, Erwan Pernet, Eleonora Scarlata, Lucie Hamel, Fadi Brimo, Maziar Divangahi, Armen G. Aprikian, Simone Chevalier, Vincent Giguère and Jacques Lapointe. https://www.nature.com/articles/s41388-022-02276-z


Starvation, nutrient sensing


O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine – Kibum Kim, Hee Chan Yoo, Byung Gyu Kim, Sulhee Kim, Yulseung Sung, Ina Yoon, Ya Chun Yu, Seung Joon Park, Jong Hyun Kim, Kyungjae Myung, Kwang Yeon Hwang, Sunghoon Kim and Jung Min Han. https://www.nature.com/articles/s41467-022-30696-8

Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming – Lu Qiu, Qiufang Yang, Wenshan Zhao, Yadi Xing, Peng Li, Xiaowen Zhou, Haoming Ning, Ranran Shi, Shanshan Gou, Yalan Chen, Wenjie Zhai, Yahong Wu, Guodong Li, Zhenzhen Chen, Yonggang Ren, Yanfeng Gao, Yiguo Zhang and Yuanming Qi. https://www.nature.com/articles/s41419-022-04917-3

Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer – Yogev Sela, Jinyang Li, Shivahamy Maheswaran, Robert J Norgard, Salina Yuan, Maimon E Hubbi, Miriam Doepner, Jimmy P Xu, Elaine S Ho, Clementina Mesaros, Colin Sheehan, Grace Croley, Alexander Muir, Ian A Blair, Ophir Shalem, Chi V Dang, Ben Z Stanger. https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-0431/682341

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity – Qian Li, Xiaofang Zhong, Weicheng Yao, Junli Yu, Chao Wang, Zongyan Li, Shengqing Lai, Fanli Qu, Xiaoyan Fu, Xiaojia Huang, Dawei Zhang, Yujie Liu, Haiyan Li. https://www.jbc.org/article/S0021-9258(22)00193-4/fulltext


mTOR / AMPK


PET-Based Radiogenomics Supports mTOR Pathway Targeting for Hepatocellular Carcinoma – Jihyun An, Minyoung Oh, Seog-Young Kim, Yoo-Jin Oh, Bora Oh, Ji-Hye Oh, Wonkyung Kim, Jin Hwa Jung, Ha Il Kim, Jae-Seung Kim, Chang Ohk Sung, Ju Hyun Shim. https://aacrjournals.org/clincancerres/article-abstract/28/9/1821/694445

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth – Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00595-2

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation – Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein. https://www.jbc.org/article/S0021-9258(22)00190-9/fulltext

Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3 – Yuxiang Liu, Tao V. Wang, Yunfeng Cui, Shengxian Gao, Yi Rao. https://www.jbc.org/article/S0021-9258(22)00369-6/fulltext


Metabolism and angiogenesis


Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis – Roxana E. Oberkersch, Giovanna Pontarin, Matteo Astone, Marianna Spizzotin, Liaisan Arslanbaeva, Giovanni Tosi, Emiliano Panieri, Sara Ricciardi, Maria Francesca Allega, Alessia Brossa, Paolo Grumati, Benedetta Bussolati, Stefano Biffo, Saverio Tardito, Massimo M. Santoro. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00286-6

The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo – Jin Yao, Xin-yuan Wu, Qing Yu, Shuo-fei Yang, Jin Yuan, Zhi-qing Zhang, Jin-song Xue, Qin Jiang, Min-bin Chen, Guan-hua Xue, Cong Cao. https://www.science.org/doi/full/10.1126/sciadv.abn6928

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors – Xiaomin Wang, Ziqi Chen, Jun Xu, Shuai Tang, Nan An, Lei Jiang, Yixiang Zhang, Shaoying Zhang, Qingli Zhang, Yanyan Shen, Shijie Chen, Xiaojing Lan, Ting Wang, Linhui Zhai, Siyuwei Cao, Siqi Guo, Yingluo Liu, Aiwei Bi, Yuehong Chen, Xiameng Gai, Yichen Duan, Ying Zheng, Yixian Fu, Yize Li, Liang Yuan, Linjiang Tong, Kun Mo, Mingcheng Wang, Shu-Hai Lin, Minjia Tan, Cheng Luo, Yi Chen, Jia Liu, Qiansen Zhang, Leping Li, Min Huang.. https://www.nature.com/articles/s41422-022-00650-w


Cancer Immunometabolism


Obesity modulates the immune macroenvironment associated with breast cancer development – Aleida Núñez-Ruiz, Flor Sánchez-Brena, Cynthia López-Pacheco, Naray A Acevedo-Domínguez, Gloria Soldevila.. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266827


Miscellaneous


A pan-cancer metabolic atlas of the tumor microenvironment – Neha Rohatgi, Umesh Ghoshdastider, Probhonjon Baruah, Tanmay Kulshrestha, Anders Jacobsen Skanderup. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00567-8

Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer, The MA.32 Randomized Clinical Trial – Pamela J. Goodwin, Bingshu E. Chen, Karen A. Gelmon, Timothy J. Whelan, Marguerite Ennis, Julie Lemieux, Jennifer A. Ligibel, Dawn L. Hershman, Ingrid A. Mayer, MD9, Timothy J. Hobday, Judith M. Bliss, Priya Rastogi, Manuela Rabaglio-Poretti, Som D. Mukherjee, John R. Mackey, Vandana G. Abramson, Conrad Oja, Robert Wesolowski, Alastair M. Thompson, Daniel W. Rea, Paul M. Stos, Lois E. Shepherd, Vuk Stambolic, Wendy R. Parulekar. https://jamanetwork.com/journals/jama/fullarticle/2792615

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes – Sophia Maschalidi, Parul Mehrotra, Burcu N. Keçeli, Hannah K. L. De Cleene, Kim Lecomte, Renée Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-022-04754-6

Comprehensive Analysis of Metabolic Isozyme Targets in Cancer – Michal Marczyk, Vignesh Gunasekharan, David Casadevall, Tao Qing, Julia Foldi, Raghav Sehgal, Naing Lin Shan, Kim R.M. Blenman, Tess A. O’Meara, Sheila Umlauf, Yulia V. Surovtseva, Viswanathan Muthusamy, Jesse Rinehart, Rachel J. Perry, Richard Kibbey, Christos Hatzis, Lajos Pusztai. https://aacrjournals.org/cancerres/article-abstract/82/9/1698/694711


Reviews


Transcriptional control of energy metabolism by nuclear receptors – Charlotte Scholtes and Vincent Giguère. https://www.nature.com/articles/s41580-022-00486-7

Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer – Gerardo M. Nava and Luis Alberto Madrigal-Perez. https://www.tandfonline.com/doi/abs/10.1080/14737159.2022.2065196?journalCode=iero20

Targeting oncometabolism to maximize immunotherapy in malignant brain tumors – Joshua D. Bernstock, Kyung-Don Kang, Neil V. Klinger, Hannah E. Olsen, Sam Gary, Stacie K. Totsch, Gelare Ghajar-Rahimi, David Segar, Eric M. Thompson, Victor Darley-Usmar, Bryan T. Mott, Luca Peruzzotti-Jametti and Gregory K. Friedman. https://www.nature.com/articles/s41388-022-02312-y

Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer – Pasquale Saggese, Assunta Sellitto, Cesar A. Martinez, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Roberta Tarallo and Claudio Scafoglio. https://www.mdpi.com/2072-6694/12/12/3788

Targeting Stearoyl-CoA Desaturase in Solid Tumors – Casie S. Kubota; Peter J. Espenshade. https://aacrjournals.org/cancerres/article-abstract/82/9/1682/694698

Metabolic tricks of cancer cells – Katerina Hönigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska, Michal Masarik. https://www.sciencedirect.com/science/article/abs/pii/S0304419X22000300

The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors – Xuemin Wang; Christopher G. Proud. https://portlandpress.com/biochemj/article-abstract/479/10/1059/231335

mTOR substrate phosphorylation in growth control – Stefania Battaglioni, Don Benjamin, Matthias Wälchli, Timm Maier, Michael N. Hall. https://www.cell.com/cell/fulltext/S0092-8674(22)00460-3

KEAP1-Mutant NSCLC: The Catastrophic Failure of a Cell-Protecting Hub – Stefano Scalera, Marco Mazzotta, Clelia Cortile, Eriseld Krasniqi, Ruggero De Maria, Federico Cappuzzo, Gennaro Ciliberto, Marcello Maugeri-Saccà. https://www.jto.org/article/S1556-0864(22)00166-6


Comments


Metabolic diversity drives cancer cell invasion – Sanjeethan C. Baksh and Lydia W. S. Finley. https://www.nature.com/articles/d41586-022-01301-1

Who Will Benefit From Metformin? – Joanne E. Mortimer; Victoria Seewaldt. https://jamanetwork.com/journals/jamaoncology/fullarticle/2792811

Formate for tumor progression – Annalisa M. VanHook. https://www.science.org/doi/full/10.1126/scisignal.add1844

Upcoming conferences:

PIVAC – Torino, Italy. September 22.. Conference about immunotherapy, with focus on microenvironment and metabolism. https://www.pivac22.it/

CIMUS symposium, Santiago, July 22. Organized by Rubén Nogueiras, Carlos Diéguez, Miguel López, Jose L. Labandeira, Fernando Dominguez, Diana Guallar, Ricardo Villa-Bellosta, includes several sessions about metabolism and disease https://www.cimussymposium.com/en/index.php

MetaboList – April 2022


Ketones / Lipids / Acetate


β-Hydroxybutyrate suppresses colorectal cancer – Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Hélène C. Descamps, Lenka Dohnalová, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss and Maayan Levy. https://www.nature.com/articles/s41586-022-04649-6

Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression – Victoire Gouirand, Tristan Gicquel, Evan C Lien, Emilie Jaune-Pons,  Quentin Da Costa,  Pascal Finetti,  Elodie Metay, Camille Duluc, Jared R Mayers, Stephane Audebert,  Luc Camoin, Laurence Borge, Marion Rubis, Julie Leca, Jeremy Nigri, François Bertucci, Nelson Dusetti, Juan Lucio Iovanna, Richard Tomasini, Ghislain Bidaut, Fabienne Guillaumond, Matthew G Vander Heiden, Sophie Vasseur. https://www.embopress.org/doi/abs/10.15252/embj.2021110466

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer – Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman and Afshin Samali. https://www.nature.com/articles/s41467-022-30159-0

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration – Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida, Toshio Suda. https://www.embopress.org/doi/abs/10.15252/embj.2021109463

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma – Min Tang, Xin Dong […] Ya Cao. https://www.nature.com/articles/s41419-022-04730-y

Altered propionate metabolism contributes to tumour progression and aggressiveness – Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt and John Blenis. https://www.nature.com/articles/s42255-022-00553-5

Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer – Luigi Ippolito, Giuseppina Comito, Matteo Parri, Marta Iozzo, Assia Duatti, Francesca Virgilio, Nicla Lorito, Marina Bacci, Elisa Pardella, Giada Sandrini, Francesca Bianchini, Roberta Damiano, Lavinia Ferrone, Giancarlo la Marca, Sergio Serni, Pietro Spatafora, Carlo V. Catapano, Andrea Morandi, Elisa Giannoni, Paola Chiarugi. https://aacrjournals.org/cancerres/article-abstract/82/7/1267/694059


Mitochondria


Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma – Xin Ge, Mengdie Li, Jianxing Yin, Zhumei Shi, Yao Fu, Ningwei Zhao, Hongshan Chen, Longxiyu Meng, Xinjian Li, Zhibin Hu, Xiaozhi Zhao, Hongqian Guo, Xu Qian. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00105-8

Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with SDHB gene mutation – Takao Kamai, Satoshi Murakami, Kyoko Arai, Daisaku Nishihara, Toshitaka Uematsu, Kazuyuki Ishida, Toshiki Kijima. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09415-5

Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells – Jin-Song Yan, Meng-Ying Yang, Xue-Hong Zhang, Chen-Hui Luo, Cheng-Kan Du, Yue Jiang, Xuan-Jia Dong, Zhang-Man Wang, Li-Xue Yang, Yi-Dong Li, Li Xia and Ying Lu. https://www.nature.com/articles/s41419-022-04842-5

PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer – Carmen Ghilardi, Catarina Moreira-Barbosa, Laura Brunelli, Paola Ostano, Nicolò Panini, Monica Lupi, Alessia Anastasia, Fabio Fiordaliso, Monica Salio, Laura Formenti, Massimo Russo, Edoardo Arrigoni, Ferdinando Chiaradonna, Giovanna Chiorino, Giulio Draetta, Joseph R. Marszalek, Christopher P. Vellano, Roberta Pastorelli, MariaRosa Bani, Alessandra Decio, Raffaella Giavazzi. https://aacrjournals.org/cancerres/article/82/7/1423/694053

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer – Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji. https://www.sciencedirect.com/science/article/pii/S2212877822000382


Starvation / AMPK


Carbon starvation, senescence and specific mitochondrial stresses, but not nitrogen starvation and general stresses, are major triggers for mitophagy in Arabidopsis – Sylwia M. Kacprzak and Olivier Van Aken. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2054039

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis – Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00525-3


Hypoxia


NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment – Irene Bertolini, Michela Perego, Jagadish C. Ghosh, Andrew V. Kossenkov and Dario C. Altieri. https://www.nature.com/articles/s41388-022-02280-3

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation – Koh Nakayama, Sigal Shachar, Elizabeth H. Finn, Hiroyuki Sato, AkihiroHirakawa, and Tom Misteli. https://www.molbiolcell.org/doi/10.1091/mbc.E21-11-0593?ai=25zg&ui=2oy6&af=T

Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress – Sandhya Chipurupalli, Raja Ganesan, Giulia Martini, Luigi Mele, Alessio Reggio, Marianna Esposito, Elango Kannan, Vigneshwaran Namasivayam, Paolo Grumati, Vincenzo Desiderio and Nirmal Robinson. https://www.nature.com/articles/s41419-022-04813-w


Cancer Immunometabolism


Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer – Sarah A. Best, Patrick M. Gubser, Shalini Sethumadhavan,  Ariena Kersbergen., Yashira L. Negrón Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L. Garnham, Jackson A. McDonald, Clare E. Weeden, Dovile Anderson, David Pirman, Thomas P. Roddy, Darren J. Creek, Axel Kallies, Gillian Kingsbury, Kate D. Sutherland. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00130-9

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells – Jia Xiong, Jia He, Jun Zhu, Jiongli Pan, Weijie Liao, Hongying Ye, Haofei Wang, Yinjing Song, Yue Du, Bijun Cui, Maoguang Xue, Wanling Zheng, Xiangxing Kong, Kai Jiang, Kefeng Ding, Lihua Lai, Qingqing Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00207-6

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function – Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martín, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00127-9

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer – Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang. https://aacrjournals.org/cancerres/article-abstract/82/8/1575/694351

Metabolism drives macrophage heterogeneity in the tumor microenvironment – Shasha Li, Jiali Yu, Amanda Huber, Ilona Kryczek, Zhuwen Wang, Long Jiang, Xiong Li, Wan Du, Gaopeng Li, Shuang Wei, Linda Vatan, Wojciech Szeliga, Arul M. Chinnaiyan, Michael D. Green, Marcin Cieslik, Weiping Zou. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00357-6

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy – Lupeng Ye, Jonathan J. Park, Lei Peng, Quanjun Yang, Ryan D. Chow, Matthew B. Dong, Stanley Z. Lam, Jianjian Guo, Erting Tang, Yueqi Zhang, Guangchuan Wang, Xiaoyun Dai, Yaying Du, Hyunu R. Kim, Hanbing Cao, Youssef Errami, Paul Clark, Alexey Bersenev, Ruth R. Montgomery, Sidi Chen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00053-5

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 – Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00036-8


Glucose metabolism/lactate


Hexokinase 1 cellular localization regulates the metabolic fate of glucose – Adam De Jesus, Farnaz Keyhani-Nejad, Carolina M. Pusec, Lauren Goodman, Justin A. Geier, Joshua S. Stoolman, Paulina J. Stanczyk, Tivoli Nguyen, Kai Xu, Krishna V. Suresh, Yihan Chen, Arianne E. Rodriguez, Jason S. Shapiro, Hsiang-Chun Chang, Chunlei Chen, Kriti P. Shah, Issam Ben-Sahra, Brian T. Layden, Navdeep S. Chandel, Samuel E. Weinberg, Hossein Ardehali. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00166-6

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway – Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel. https://elifesciences.org/articles/69223

NEDD9 sustains hexokinase expression to promote glycolysis – Alexander Y. Deneka, Anna S. Nikonova, Hyung-Ok Lee, Warren D. Kruger and Erica A. Golemis. https://www.nature.com/articles/s41389-022-00391-w

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth – Chunwan Lu, Dafeng Yang, John D. Klement, Yolonda L. Colson, Nicholas H. Oberlies, Cedric J. Pearce, Aaron H. Colby, Mark W. Grinstaff, Zhuoqi Liu, Huidong Shi, Han-Fei Ding and Kebin Liu. https://www.nature.com/articles/s41388-022-02283-0

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis – Xuetian Yue, Jianming Wang, Chun-yuan Chang, Juan Liu, Xue Yang, Fan Zhou, Xia Qiu, Vrushank Bhatt, Jessie Yanxiang Guo, Xiaoyang Su, Lanjing Zhang, Zhaohui Feng and Wenwei Hu. https://www.nature.com/articles/s41419-022-04820-x

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells – Vivian Morris, Dahai Wang, Zhiheng Li, William Marion, Travis Hughes, Patricia Sousa, Taku Harada, Shannan Ho Sui, Sergey Naumenko, Jérémie Kalfon, Prerana Sensharma, Marcelo Falchetti, Renan Vinicius da Silva, Tito Candelli, Pauline Schneider, Thanasis Margaritis, Frank C.P. Holstege, Yana Pikman, Marian Harris, Ronald W. Stam, Stuart H. Orkin, Angela N. Koehler, Alex K. Shalek, Trista E. North, Maxim Pimkin, George Q. Daley, Edroaldo Lummertz da Rocha, R. Grant Rowe. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00516-2

A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma – Jennifer G. Gill, Samantha N. Leef, Vijayashree Ramesh, Misty S. Martin-Sandoval, Aparna D. Rao, Lindsey West, Sarah Muh, Wen Gu, Zhiyu Zhao, Gregory A. Hosler, Travis W. Vandergriff, Alison B. Durham, Thomas P. Mathews, Arin B. Aurora. https://aacrjournals.org/cancerres/article-abstract/82/7/1251/694035

A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer – Emanuela Dylgjeri, Vishal Kothari, Ayesha A. Shafi, Galina Semenova, Peter T. Gallagher, Yi F. Guan, Angel Pang, Jonathan F. Goodwin, Swati Irani, Jennifer J. McCann, Amy C. Mandigo, Saswati Chand, Christopher M. McNair, Irina Vasilevskaya, Matthew J. Schiewer, Costas D. Lallas,  Peter A. McCue, Leonard G. Gomella, Erin L. Seifert, Jason S. Carroll, Lisa M. Butler, Jeff Holst, William K. Kelly, Karen E. Knudsen. https://aacrjournals.org/clincancerres/article/28/7/1446/682199/

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability – Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante and Jan Jacob Schuringa. https://www.nature.com/articles/s41467-022-29639-0


Amino acid metabolism


MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis – Hamed Alborzinia, Andrés F. Flórez, Sina Kreth, Lena M. Brückner, Umut Yildiz, Moritz Gartlgruber, Dorett. Odoni, Gernot Poschet, Karolina Garbowicz, Chunxuan Shao, Corinna Klein, Jasmin Meier, Petra Zeisberger, Michal Nadler-Holly, Matthias Ziehm, Franziska Paul, Jürgen Burhenne, Emma Bell, Marjan Shaikhkarami, Roberto Würth, Sabine A. Stainczyk, Elisa M. Wecht, Jochen Kreth, Michael Büttner, Naveed Ishaque, Matthias Schlesner, Barbara Nicke, Carlo Stresemann, María Llamazares-Prada, Jan H. Reiling, Matthias Fischer, Ido Amit, Matthias Selbach, Carl Herrmann, Stefan Wölfl, Kai-Oliver Henrich, Thomas Höfer, Andreas Trumpp and Frank Westermann. https://www.nature.com/articles/s43018-022-00355-4

Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial – Funda Meric-Bernstam, Nizar M. Tannir, Othon Iliopoulos, Richard J. Lee, Melinda L. Telli, Alice C. Fan, Angela DeMichele, Naomi B. Haas, Manish R. Patel, James J. Harding, Martin H. Voss, Taofeek K. Owonikoko, Bradley Carthon, Ramaprasad Srinivasan, Johanna C. Bendell, Yonchu Jenkins, Sam H. Whiting, Keith Orford, Mark K. Bennett, Todd M. Bauer. https://aacrjournals.org/clincancerres/article-abstract/28/8/1540/694145

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy – Mario R. Fernandez, Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, rank C. Dorsey, Min Liu, Meredith A. Steeves, Andrea Ballabio, Alexandar Tzankov, Zhihua Chen, John M. Koomen, Anders E. Berglund, John L. Cleveland. https://aacrjournals.org/cancerres/article/82/7/1234/694032

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML – Chang Liu, Waiyi Zou, Danian Nie, Shuyi Li, Chen Duan, Min Zhou, Peilong Lai, Shengyong Yang, Sen Ji, Yangqiu Li, Mei Mei, Shilai Bao, Yanli Jin, Jingxuan Pan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00131-0

Characterization of metabolic alterations of Chronic Lymphocytic Leukemia in the lymph node microenvironment – Zhenghao Chen,  Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, Michel van Weeghel, Dean Bryant, Jaco A. C. van Bruggen, F. S. Peters, Jeffrey C. Rathmell, G.J.W. van der Windt, Arnon P Kater, Graham Packham, Eric Eldering. https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2021013990/485126


Miscellaneous


Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia – Elisabeth Wyart, Myriam Y Hsu, Roberta Sartori, Erica Mina, Valentina Rausch, Elisa S Pierobon, Mariarosa Mezzanotte, Camilla Pezzini, Laure B Bindels, Andrea Lauria, Fabio Penna, Emilio Hirsch, Miriam Martini, Massimiliano Mazzone, Antonella Roetto, Simonetta Geninatti Crich, Hans Prenen, Marco Sandri, Alessio Menga, Paolo E Porporato. https://www.embopress.org/doi/full/10.15252/embr.202153746

Integrative metabolomic characterization identifies plasma metabolomic signature in the diagnosis of papillary thyroid cancer – Shuang Yu, Changan Liu, Yingtong Hou, Jie Li, Zhuming Guo, Xinwen Chen, Luyao Zhang, Sui Peng, Shubin Hong, Lixia Xu, Xiaoxing Li, Rengyun Liu, Shuwei Chen, Bin Li, Zongpeng Weng, Yanbing Li, Weiming Lv, Jun Yu and Haipeng Xiao. https://www.nature.com/articles/s41388-022-02254-5

Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms – James R. Larkin, Susan Anthony, Vanessa A. Johanssen, Tianrong Yeo, Megan Sealey, Abi G. Yates, Claire Friedemann Smith, Timothy D.W. Claridge, Brian D. Nicholson, Julie-Ann Moreland, Fergus Gleeson, Nicola R. Sibson, Daniel C. Anthony, Fay Probert. https://aacrjournals.org/clincancerres/article/28/8/1651/694157

Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy – Marta Mascaraque-Checa, María Gallego-Rentero, Jimena Nicolás-Morala, Mikel Portillo-Esnaola, José M. Cuezva, Salvador González, Yolanda Gilaberte, Ángeles Juarranz. https://www.sciencedirect.com/science/article/pii/S2212877822000655

An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition – Maurizio Ragni, Chiara Ruocco, Laura Tedesco, Michele O.Carruba, Alessandra Valerio, Enzo Nisoli. https://www.sciencedirect.com/science/article/pii/S2212877822000473

Atg6 promotes organismal health by suppression of cell stress and inflammation – James L. Shen, Johnna Doherty, Elizabeth Allen, Tina M. Fortier and Eric H. Baehrecke. https://www.nature.com/articles/s41418-022-01014-y


Nucleotides and NADPH


Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity – Amy Tarangelo, Jason Rodencal, Joon Tae Kim, Leslie Magtanong, Jonathan Z Long and Scott J Dixon. https://www.life-science-alliance.org/content/5/4/e202101157.abstract

NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells – Chiqi Chen, Xiaoyun Lai, Yaping Zhang, Li Xie, Zhuo Yu, Sijia Dan, Yu Jiang, Weicai Chen, Ligen Liu, Yi Yang, Dan Huang, Yuzheng Zhao, Junke Zheng. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00355-2

MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers – Omar Alhalabi, Jianfeng Chen, …, and Jianjun Gao. https://www.nature.com/articles/s41467-022-29397-z


Reviews


The two sides of creatine in cancer – Liwen Zhang, Pengcheng Bu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00230-0

Regulation of chromatin accessibility by hypoxia and HIF – Michael Batie; Julianty Frost; Dilem Shakir; Sonia Rocha. https://portlandpress.com/biochemj/article/479/6/767/230989

Glutamine, MTOR and autophagy: a multiconnection relationship – Clément Bodineau, Mercedes Tomé, Piedad del Socorro Murdoch and Raúl V. Durán. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2062875

Emerging signaling mediators in the anorexia–cachexia syndrome of cancer – Erin E. Talbert, Denis C. Guttridge. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00010-3


Comments


Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival – Dohun Kim, Gerta Hoxhaj. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00375-6

Circling back to PTEN: Fumarate inhibits canonical tumor suppressor – Sally E. Claridge, Benjamin D. Hopkins. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00222-2

Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness – Emily J. Kay and Sara Zanivan. https://www.nature.com/articles/s42255-022-00540-w

Alternative cycle for citrate – Paulina Strzyz. https://www.nature.com/articles/s41580-022-00475-w

Restored Ketosis Drives Anticancer Immunity in Colorectal Cancer – David C. Montrose, Lorenzo Galluzzi. https://aacrjournals.org/cancerres/article-abstract/82/8/1464/694347

In an Era of ctDNA, Is Metabolomics the New Kid on the Block? – Brian A. Van Tine, Costas A. Lyssiotis. https://aacrjournals.org/clincancerres/article-abstract/28/8/1477/694166

Cell scientist to watch – Lydia Finley. https://journals.biologists.com/jcs/article/135/7/jcs260023/274953

Dying cell-derived SAM switches off inflammation – Roel P. H. De Maeyer and Derek W. Gilroy. https://www.nature.com/articles/s42255-022-00556-2

A FAsT contribution: Adipocytes rewire their metabolism to acquire immune functions – Takumi Kobayashi, Dirk Brenner. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00134-6?


Profile of Ana Maria Cuervo  – Sandeep Ravindran. https://www.pnas.org/doi/10.1073/pnas.2204524119?ai=aqle&ui=c8ih&af=T

MetaboList – March 2022


Glucose metabolism


A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine – Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi, Nadia Ducano, Alessia Mira, Manasvi S. Shah, Sylwia A. Stopka, Andrew J. Perciaccante, Claudio Isella, Daniel Moya-Rull, Marianela Vara-Messler, Silvia Giordano, Elena Maldi, Niyati Desai, Diane E. Capen, Enzo Medico, Murat Cetinbas, Ruslan I. Sadreyev, Dennis Brown, Miguel N. Rivera, Anna Sapino, David T. Breault, Nathalie Y. R. Agar and Raul Mostoslavsky. https://www.nature.com/articles/s41467-022-29085-y

MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer – Cannistraci, P. Hascoet, A. Ali, P. Mundra, N. W. Clarke, V. Pavet and R. Marais. https://www.nature.com/articles/s41388-022-02178-0

Aminopyridine analogs selectively target metastatic pancreatic cancer – Rana V. Smalling, Matthew E. Bechard, Jeff Duryea, Philip J. Kingsley, Evan R. Roberts, Lawrence J. Marnett, Daniel Bilbao, Shaun R. Stauffer and Oliver G. McDonald. https://www.nature.com/articles/s41388-022-02183-3

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma – Jia Li, Zhi-Qiang Hu, Song-Yang Yu, Li Mao; Zheng-Jun Zhou, Peng-Cheng Wang, Yu Gong; Sheng Su, Jian Zhou, Jia Fan, Shao-Lai Zhou, Xiao-Wu Huang. https://aacrjournals.org/cancerres/article-abstract/82/6/1055/682071


Amino acids


Tryptophan depletion results in tryptophan-to-phenylalanine substitutants – Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper and Reuven Agami. https://www.nature.com/articles/s41586-022-04499-2

For more papers on glutamine metabolism follow https://twitter.com/sreeparna_b

http://biomed.news/bims-glucam/2022-03-06

http://biomed.news/bims-glucam/2022-03-20

http://biomed.news/bims-glucam/2022-03-13

http://biomed.news/bims-glucam/2022-03-27


Lipid metabolism / acetate


Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia – Marissa Rashkovan, Robert Albero, Francesca Gianni, Pablo Perez-Duran, Hannah I. Miller, Adam L. Mackey, Elisabeth M. Paietta, Martin S. Tallman, Jacob M. Rowe, Mark R. Litzow, Peter H. Wiernik, Selina Luger, Maria Luisa Sulis, Rajesh K. Soni, Adolfo A. Ferrando. https://aacrjournals.org/cancerdiscovery/article/12/3/856/681883

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation – Lorela Ciraku, Zachary A. Bacigalupa, Jing Ju, Rebecca A. Moeller, Giang Le Minh, Rusia H. Lee, Michael D. Smith, Christina M. Ferrer, Sophie Trefely, Luke T. Izzo, Mary T. Doan, Wiktoria A. Gocal, Luca D’Agostino, Wenyin Shi, Joshua G. Jackson, Christos D. Katsetos, Kathryn E. Wellen, Nathaniel W. Snyder and Mauricio J. Reginato. https://www.nature.com/articles/s41388-022-02237-6


Nucleotides


Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex – Sharon Spizzichino, Dalila Boi, Giovanna Boumis, Roberta Lucchi, Francesca Romana Liberati, Davide Capelli, Roberta Montanari, Giorgio Pochetti, Roberta Piacentini, Giacomo Parisi, Alessio Paone, Serena Rinaldo, Roberto Contestabile, Angela Tramonti, Alessandro Paiardini, Giorgio Giardina, Francesca Cutruzzolà. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16248


Mitochondria and iron


CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH – Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00226-1

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death – Sylvain Garciaz, Andrew A. Guirguis, Sebastian Müller, Fiona C. Brown, Yih-Chih Chan, Ali Motazedian, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y.N. Lam, Tatiana Cañeque, Marian L. Burr, Véronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C.S. Huang, Andrew H. Wei, Kate McArthur, Raphaël Rodriguez, Mark A. Dawson. https://aacrjournals.org/cancerdiscovery/article/12/3/774/681925

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma – Julie Devin, Tatiana Cañeque, Yea-Lih Lin, Lucie Mondoulet, Jean-Luc Veyrune, Matthieu Abouladze, Elvira Garcia De Paco, Ouissem Karmous Gadacha, Guillaume Cartron, Philippe Pasero, Caroline Bret, Raphaël Rodriguez, Jerome Moreaux. https://aacrjournals.org/cancerres/article/82/6/998/682058

Mitochondrial respiration supports autophagy to provide stress resistance during quiescence – Silvia Magalhaes-Novais, Jan Blecha, Ravindra Naraine, Jana Mikesova, Pavel Abaffy, Alena Pecinova, Mirko Milosevic, Romana Bohuslavova, Jan Prochazka, Shawez Khan, Eliska Novotna, Radek Sindelka, Radek Machan, Mieke Dewerchin, Erik Vlcak, Joanna Kalucka, Sona Stemberkova Hubackova, Ales Benda, Jermaine Goveia, Tomas Mracek, Cyril Barinka, Peter Carmeliet, Jiri Neuzil, Katerina Rohlenova and Jakub Rohlena. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2038898

Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice – Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz-Barneo, G. R. Scott Budinger and Navdeep S. Chandel. https://www.nature.com/articles/s41598-022-09074-3


Starvation / nutrient sensing


Amino acid starvation‐induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance – Ye Chen, Xiao Wu, Jing Zhang, Guopin Pan, Xiaoyun Wang, Xiaosun Guo, Jianli Wang, Xiaopei Cui, Haiqing Gao, Mei Cheng, Jingwen Yang, Cheng Zhang, Fan Jiang. https://www.embopress.org/doi/full/10.15252/embr.202153373

Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation – Kamilla M. E. Laidlaw, Katherine M. Paine, Daniel D. Bisinski, Grant Calder, Karen Hogg, Sophia Ahmed, Sally James, Peter J. O’Toole, and Chris MacDonald. https://www.molbiolcell.org/doi/full/10.1091/mbc.E21-04-0163

Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer – Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao, Peng Gao. https://aacrjournals.org/cancerres/article-abstract/82/5/805/681782


Hypoxia


Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy – Jingyi Li, Tao Zhang, Tao Ren, Xiaoyu Liao, Yilong Hao, Je Sun Lim, Jong-Ho Lee, Mi Li, Jichun Shao and Rui Liu. https://www.nature.com/articles/s41467-022-28831-6


IDH


Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma – Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E. Olander, Ramzi Adil, Amaya Pankaj, Krishna Seshu Tummala, Vajira Weeresekara, Yuanli Zhen, Qibiao Wu, Meiqi Luo, William Shen, María García-Beccaria, Mirian Fernández-Vaquero, Christine Hudson, Sebastien Ronseaux, Yi Sun; Rodrigo Saad-Berreta, Russell W. Jenkins, Tong Wang, Mathias Heikenwälder, Cristina R. Ferrone, Lipika Goyal, Brandon Nicolay, Vikram Deshpande, Rahul M. Kohli, Hongwu Zheng, Robert T. Manguso, Nabeel Bardeesy. https://aacrjournals.org/cancerdiscovery/article/12/3/812/68192


Cancer Immunometabolism


Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses – Kunle Odunsi, Feng Qian, Amit A. Lugade, Han Yu, Melissa A. Geller, Steven P. Fling, Judith C. Kaiser, Andreanne M. Lacroix, Leonard D’Amico, Nirasha Ramchurren, Chihiro Morishima, Mary L. Disis, Lucas Dennis, Patrick Danaher, Sarah Warren, Van Anh Nguyen, Sudharshan Ravi, Takemasa Tsuji, Spencer Rosario, Wenjuan Zha, Alan Hutson, Song Liu, Shashikant Lele, Emese Zsiros, A. J. Robert McGray, Jessie Chiello, Richard Koya, Thinle Chodon, Carl D. Morrison, Vasanta Putluri, Nagireddy Putluri, Donald E. Mager, Rudiyanto Gunawan, Martin A. Cheever, Sebastiano Battaglia, Junko Matsuzaki. https://www.science.org/doi/abs/10.1126/scitranslmed.abg8402

Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma – Brooks P. Leitner, Kevin B. Givechian, Shyryn Ospanova, Aray Beisenbayeva, Katerina Politi and Rachel J. Perry. https://www.nature.com/articles/s41698-021-00248-2


Miscellaneous


Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis – Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras and Patricia Aspichueta. https://www.nature.com/articles/s41467-022-28749-z

Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer – Caner Yelek, Lionel Mignion, Adrien Paquot, Caroline Bouzin, Cyril Corbet, Giulio G Muccioli, Patrice D Cani, Bénédicte F Jordan. https://www.mdpi.com/2072-6694/14/3/562

Angiocrine polyamine production regulates adiposity – Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura Herrero, Rui Benedito, Pablo Garcia-Roves, Josep Vidal, Paul Cohen, Rubén Nogueiras, Marc Claret, Arkaitz Carracedo and Mariona Graupera. https://www.nature.com/articles/s42255-022-00544-6


Reviews


NRF2: KEAPing Tumors Protected – Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos. https://aacrjournals.org/cancerdiscovery/article/12/3/625/681905

Advancing Cancer Treatment by Targeting Glutamine Metabolism-A Roadmap – Anna Halama, Karsten Suhre. https://www.mdpi.com/2072-6694/14/3/553

Structural advances in sterol-sensing domain-containing proteins – Xuelan Wu, Renhong Yan, Pingping Cao, Hongwu Qian, Nieng Yan. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00274-7

Insulin and cancer: a tangled web – Brooks P. Leitner, Stephan Siebel, Ngozi D. Akingbesote, Xinyi Zhang, Rachel J. Perry. https://portlandpress.com/biochemj/article/479/5/583/230979

The central moTOR of metabolism – Judith Simcox, Dudley W. Lamming. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00126-5


Comments


IDH1 Inhibition Reawakens the Immune Response against Cholangiocarcinoma – Yan Zhu, Lawrence N. Kwong. https://aacrjournals.org/cancerdiscovery/article/12/3/604/681915

MTHFD2, metabolic mastermind of CD4+ T cell destiny – Victoire Gouirand and Michael D. Rosenblum. https://www.science.org/doi/full/10.1126/sciimmunol.abo6765

Metabolic Adaptations Alter Metastatic Fitness in Brain-Tropic Breast Cancer. https://aacrjournals.org/cancerdiscovery/article/12/3/OF5/681892

CAR T-cell Efficacy in Solid Tumors Is Affected by N-glycosylation. https://aacrjournals.org/cancerdiscovery/article/12/3/598/681906

Obesity and antitumor immunity – John F. Foley. https://www.science.org/doi/full/10.1126/scisignal.abq0080

MetaboList – February 2022


Reviews


The hallmarks of cancer metabolism: Still emerging – Natalya N. Pavlova, Jiajun Zhu, Craig B. Thompson. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00022-5

Metabolic programs tailor T cell immunity in viral infection, cancer, and aging – Sofie Hedlund Møller, Pei-Chun Hsueh, Yi-Ru Yu, Lianjun Zhang, Ping-Chih Ho. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00047-X

Clinical development of metabolic inhibitors for oncology – Kathryn M Lemberg, Sadakatali S Gori, Takashi Tsukamoto, Rana Rais, Barbara S Slusher. https://www.jci.org/articles/view/148550

Diet, lipids, and antitumor immunity – Hannah Prendeville and Lydia Lynch. https://www.nature.com/articles/s41423-021-00781-x

Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling – Michael Batie, Niall S. Kenneth, Sonia Rocha. https://portlandpress.com/biochemj/article/479/3/245/230736

Persister cancer cells: Iron addiction and vulnerability to ferroptosis – Raphaël Rodriguez, Stuart L. Schreiber, Marcus Conrad. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01038-8

Interleukin 6 as an energy allocator in muscle tissue – Timothy M. Kistner, Bente K. Pedersen and Daniel E. Lieberman. https://www.nature.com/articles/s42255-022-00538-4


Starvation/metformin


Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting – Patrick Jouandin, Zvonimir Marelja, Yung-Hsin Shih, Andrey A. Parkhitko, Miriam Dambowsky, John M. Asara, Ivan Nemazanyy, Christian C. Dibble, Matias Simons, Norbert Perrimon. https://www.science.org/doi/abs/10.1126/science.abc4203

Low-dose metformin targets the lysosomal AMPK pathway through PEN2 – Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin. https://www.nature.com/articles/s41586-022-04431-8

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis – Traci E. LaMoia,  Gina M. Butrico,  Hasini A. Kalpage,  Leigh Goedeke,  Brandon T. Hubbard,  Daniel F. Vatner,  Rafael C. Gaspar,  Xian-Man Zhang,  Gary W. Cline, Keita Nakahara, Seungwan Woo,  Atsuhiro Shimada,  Maik Hüttemann and Gerald I. Shulman. https://www.pnas.org/doi/10.1073/pnas.2122287119

An AMPKα2-specific phospho-switch controls lysosomal targeting for activation – Kaitlin R. Morrison, William J. Smiles, Naomi X.Y. Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin R.W. Ngoei, Dingyi Yu, Lisa Murray-Segal, John W. Scott, Sandra Galic, Bruce.E. Kemp, Janni Petersen, Jonathan S. Oakhill. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00086-9

SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence – J Ignacio Gutierrez, Gregory P Brittingham, Yonca B Karadeniz, Kathleen D Tran, Arnob Dutta, Alex S Holehouse, Craig L Peterson, Liam J Holt. https://elifesciences.org/articles/70344


Macropinocytosis


GCN2 adapts protein synthesis to scavenging-dependent growth – Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Li, Seunghun Han, Lance Parsons, Alexander N. Frese, Zemer Gitai, Tracy G. Anthony, Martin Wühr, David M. Sabatini, Joshua D. Rabinowitz. https://www.cell.com/cell-systems/fulltext/S2405-4712(21)00382-3

A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma – Yi-Fan Zhang, Qing Li, Pei-Qi Huang, Tong Su, Shu-Heng Jiang, Li-Peng Hu, Xue-Li Zhang, Yue Sun, Hong Pan, Xiao-Mei Yang, Jun Li, Yan-Zhi Gai, Lei Zhu, Lin-Li Yao, Dong-Xue Li, Yong-Wei Sun, Zhi-Gang Zhang, De-Jun Liu, Yan-Li Zhang and Hui-Zhen Nie. https://www.cell.com/cell-systems/fulltext/S2405-4712(21)00382-3

Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer – Misty Shuo Zhang, Jane Di Cui, Derek Lee, Vincent Wai-Hin Yuen, David Kung-Chun Chiu, Chi Ching Goh, Jacinth Wing-Sum Cheu, Aki Pui-Wah Tse, Macus Hao-Ran Bao, Bowie Po Yee Wong, Carrie Yiling Chen, Chun-Ming Wong, Irene Oi-Lin Ng and Carmen Chak-Lui Wong. https://www.nature.com/articles/s41467-022-28618-9


Pentose phosphate/glucosamines


Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival – Jessica Whitburn, Srinivasa R. Rao, Emma V. Morris, Sho Tabata, Akiyoshi Hirayama, Tomoyoshi Soga, James R. Edwards, Zeynep Kaya, Charlotte Palmer, Freddie C. Hamdy, Claire M. Edwards. https://www.science.org/doi/full/10.1126/sciadv.abf9096

Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition – Nicola Facchinello, Matteo Astone, Matteo Audano, Roxana E. Oberkersch, Marianna Spizzotin, Enrica Calura, Madalena Marques, Mihaela Crisan, Nico Mitro and Massimo M. Santoro. https://www.nature.com/articles/s42255-021-00514-4

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells – Arin B. Aurora, Vishal Khivansara, Ashley Leach, Jennifer G. Gill, Misty Martin-Sandoval, Chendong Yang, Stacy Y. Kasitinon, Divya Bezwada, Alpaslan Tasdogan, Wen Gu, Thomas P. Mathews, Zhiyu Zhao, Ralph J. DeBerardinis, and Sean J. Morrison. https://www.pnas.org/content/119/6/e2120617119.abstract?etoc

The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity – Jinguan Lin, Longzheng Xia, Linda Oyang, Jiaxin Liang, Shiming Tan, Nayiyuan Wu, Pin Yi, Qing Pan, Shan Rao, Yaqian Han, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Xiaohui Chen, Lixia Yang, Yujuan Zhou and Qianjin Liao. https://www.nature.com/articles/s41388-021-02148-y

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway – Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel. https://elifesciences.org/articles/69223


Glucose metabolism


Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells – Jason Godfrey, Romain Riscal, Nicolas Skuli and M. Celeste Simon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00280-1

PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis – Yu He, Xixi Wang, Weiliang Lu, Dan Zhang, Lan Huang, Yang Luo, Li Xiong, Haocheng Li, Peng Zhang, Qiu Li and Shufang Liang. https://www.nature.com/articles/s41419-022-04576-4

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1 – Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang, Yanping Xu, and Lei Lv. https://www.pnas.org/doi/10.1073/pnas.2114851119

PKM2 Is Essential for Bladder Cancer Growth and Maintenance – Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-Shong Tang, Tung-Tien Sun, Xue-Ru Wu. https://aacrjournals.org/cancerres/article/82/4/571/678084

Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy – Adviti Naik, Julie Decock. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13024

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma – Anna Han, Vivian Chua, Usman Baqai, Timothy J. Purwin, Nelisa Bechtel, Emily Hunter, Manoela Tiago, Erin Seifert, David W. Speicher, Zachary T. Schug, J. William Harbour and Andrew E. Aplin. https://www.nature.com/articles/s41388-021-02154-0

A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis – Catherine S. Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Soeun Kang, Prashanth Bhaskar, Alexander R. Terry, Alexandre F. Aissa, Maxim V. Frolov, Krushna C. Patra, R. Brooks Robey and Nissim Hay. https://www.nature.com/articles/s41467-022-28440-3


Amino acids


Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells – Saif Sattar Alaqbi, Lynsey Burke, Inna Guterman, Caleb Green, Kevin West, Raquel Palacios-Gallego, Hong Cai, Constantinos Alexandrou, Ni Ni Moe Myint,E mma Parrott,Lynne M. Howells, Jennifer A. Higgins, Donald J. L. Jones, Rajinder Singh, Robert G. Britton, Cristina Tufarelli, Anne Thomas, Alessandro Rufini. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262364

Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer – Lingfan Xu, Bing Zhao, William Butler, Huan Xu, Nan Song, Xufeng Chen, J. Spencer Hauck, Xia Gao, Hong Zhang, Jeff Groth, Qing Yang, Yue Zhao, David Moon, Daniel George, Yinglu Zhou, Yiping He and Jiaoti Huang. https://www.nature.com/articles/s41388-021-02155-z

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer – Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Sonia Fernandez-Ruiz, Cristina Viera, Onintza Carlevaris, Amaia Ercilla, Isabel Mendizabal, Teresa Martin, Alice Macchia, Laura Camacho, Mikel Pujana-Vaquerizo, Pilar Sanchez-Mosquera, Verónica Torrano, Natalia Martin-Martin, Patricia Zuniga-Garcia, Mireia Castillo-Martin, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Miguel Unda, Jose M. Mato, Edurne Berra, Maria L. Martinez-Chantar and Arkaitz Carracedo. https://www.nature.com/articles/s41389-022-00382-x

Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth – Jiang-Sha Zhao, Shuo Shi, Hai-Yan Qu, Zuzana Keckesova, Zi-Jian Cao, Li-Xian Yang, Xiaofu Yu, Limin Feng, Zhong Shi, Joanna Krakowiak, Ruo-Ying Mao, Yi-Tong Shen, Yu-Meng Fan, Tian-Min Fu, Cunqi Ye, Daqian Xu, Xiaofei Gao, Jia You, Wenbo Li, Tingbo Liang, Zhimin Lu and Yu-Xiong Feng. https://www.nature.com/articles/s42255-021-00524-2


Folate/Nucleotides


Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress – Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson et al. and Thomas Helleday. https://www.nature.com/articles/s43018-022-00331-y

Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma – Caitlin M. O’Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla. https://aacrjournals.org/cancerres/article/82/4/721/678077


Mitochondria / lipids


Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability – Jagadish C. Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R. Goldman, Hsin-Yao Tang, Andrew V. Kossenkov, Catherine J. Libby, Lucia R. Languino, Edward F. Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W. Speicher, M. Cecilia Caino, Joel Cassel, Joseph M. Salvino, Marie E. Robert, Valentina Vaira, and Dario C. Altieri. https://www.pnas.org/doi/10.1073/pnas.2115624119

Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas – Evelyn de Groot, Sruthy Varghese, Lin Tan, Barbara Knighton, Mary Sobieski, Nghi Nguyen, Yong Sung Park, Reid Powell, Philip L. Lorenzi, Bin Zheng, Clifford Stephan and Y. N. Vashisht Gopal. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00281-0

Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate – Mengjia Zhao, Pengbo Yao, Youxiang Mao, Jinjun Wu , Weihua Wang, Chenhui Geng, Jie Cheng, Wenjing Du and Peng Jiang. https://www.nature.com/articles/s42255-022-00532-w

SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA – Hezhi Fang, Anran Xie, Miaomiao Du, Xueyun Li, Kaiqiang Yang, Yinxu Fu, Xiangshu Yuan, Runxiao Fan, Weidong Yu, Zhuohua Zhou, Tiantian Sang, Ke Nie, Jin Li, Qiongya Zhao, Zhehui Chen, Yanling Yang, Chaoyang Hong, Jianxin Lyu. https://www.science.org/doi/abs/10.1126/scitranslmed.abl6992

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis – Sampath Katakam,  eSantosh Anand, Patricia Martin, Nicolo Riggi, Ivan Stamenkovic. https://www.life-science-alliance.org/content/5/3/e202101256.abstract?etoc


Cancer Immunometabolism


Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments – Shogo Kumagai, Shohei Koyama, Kota Itahashi, Tokiyoshi Tanegashima, Yi-tzu Lin, Yosuke Togashi, Takahiro Kamada, Takuma Irie, Genki Okumura, Hidetoshi Kono, Daisuke Ito, Rika Fujii, Sho Watanabe, Atsuo Sai, Shota Fukuoka, Eri Sugiyama, Go Watanabe, Takuya Owari, Hitomi Nishinakamura, Daisuke Sugiyama, Yuka Maeda, Akihito Kawazoe, Hiroki Yukami, Keigo Chida, Yuuki Ohara, Tatsuya Yoshida, Yuki Shinno, Yuki Takeyasu, Masayuki Shirasawa, Kenta Nakama, Keiju Aokage, Jun Suzuki, Genichiro Ishii, Takeshi Kuwata, Naoya Sakamoto, Masahito Kawazu, Toshihide Ueno, Taisuke Mori, Naoya Yamazaki, Masahiro Tsuboi, Yasushi Yatabe, Takahiro Kinoshita, Toshihiko Doi, Kohei Shitara, Hiroyuki Mano, Hiroyoshi Nishikawa. https://www.sciencedirect.com/science/article/pii/S1535610822000034

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression – De Huang, Yan Wang, J. Will Thompson, Tao Yin, Peter B. Alexander, Diyuan Qin, Poorva Mudgal, Haiyang Wu, Yaosi Liang, Lianmei Tan, Christopher Pan, Lifeng Yuan, Ying Wan, Qi-Jing Li and Xiao-Fan Wang. https://www.nature.com/articles/s41556-021-00820-9

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity – Kebria Hezaveh, Rahul S. Shinde, Andreas Klötgen, Marie Jo Halaby, Sara Lamorte, M. Teresa Ciudad, Rene Quevedo, Luke Neufeld, Zhe Qi Liu, Robbie Jin, Barbara T. Grünwald, Elisabeth G. Foerster, Danica Chaharlangi, Mengdi Guo, Priya Makhijani, Xin Zhang, Trevor J. Pugh, Devanand M. Pinto, Ileana L. Co, Alison P. McGuigan, Gun Ho Jang, Rama Khokha, Pamela S. Ohashi, Grainne M. O’Kane, Steven Gallinger, William W. Navarre, Heather Maughan, Dana J. Philpott, David G. Brooks, Tracy L. McGaha. https://www.cell.com/immunity/fulltext/S1074-7613(22)00035-8


Miscellaneous


Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer – Zuen Ren, Huizhi Liang, Phillip M. Galbo Jr, Malindrie Dharmaratne, Ameya S. Kulkarni, Atefeh Taherian Fard, Marie Louise Aoun, Nuria Martinez-Lopez, Kimita Suyama, Outhiriaradjou Benard, Wei Zheng, Yang Liu, Joseph Albanese, Deyou Zheng, Jessica C. Mar, Rajat Singh, Michael B. Prystowsky, Larry Norton, and Rachel B. Hazan. https://www.pnas.org/doi/10.1073/pnas.2107266119

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers – Chengheng Liao; Cherise Ryan Glodowski; Cheng Fan; Juan Liu; Kevin R. Mott; Akash Kaushik; Hieu Vu; Jason W. Locasale; Samuel K. McBrayer; Ralph J. DeBerardinis; Charles M. Perou; Qing Zhang. https://aacrjournals.org/cancerres/article/82/4/665/678072

SOX2 mediates metabolic reprogramming of prostate cancer cells – Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth A. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz and Donald J. Vander Griend. https://www.nature.com/articles/s41388-021-02157-x

Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis – Hitomi Yamamoto-Imoto, Satoshi Minami, Tatsuya Shioda, Yurina Yamashita, Shinsuke Sakai, Shihomi Maeda, Takeshi Yamamoto, Shinya Oki, Mizuki Takashima, Tadashi Yamamuro, Kyosuke Yanagawa, Ryuya Edahiro, Miki Iwatani, Mizue So, Ayaka Tokumura, Toyofumi Abe, Ryoichi Imamura, Norio Nonomura, Yukinori Okada, Donald E. Ayer, Hidesato Ogawa, Eiji Hara, Yoshitsugu Takabatake, Yoshitaka Isaka, Shuhei Nakamura, Tamotsu Yoshimori. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00171-1

Label-free sensing of cells with fluorescence lifetime imaging: The quest for metabolic heterogeneity – Evgeny A. Shirshin, Marina V. Shirmanova, Alexey V. Gayer, Maria M. Lukina, Elena E. Nikonova, Boris P. Yakimov, Gleb S. Budylin, Varvara V. Dudenkova, Nadezhda I. Ignatova, Dmitry V. Komarov, Vladislav V. Yakovlev, Wolfgang Becker, Elena V. Zagaynova, Vladislav I. Shcheslavskiy and Marlan O. Scully. https://www.pnas.org/doi/10.1073/pnas.2118241119

Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX – Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris and Jaromir Pastorek. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00279-8


Comments


Rag GTPases regulate cellular amino acid homeostasis – Ken Inoki and Kun-Liang Guan. https://www.pnas.org/doi/10.1073/pnas.2200788119

Immune sensing of microbial metabolites: Action at the tumor – Timothy L. Frankel, Marina Pasca di Magliano. https://www.cell.com/immunity/fulltext/S1074-7613(22)00038-3

Beating cancer one carbon at a time – Vasilis S. Dionellis and Thanos D. Halazonetis. https://www.nature.com/articles/s43018-022-00333-w

MetaboList – January 2022


Glucose metabolism


The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis – Youming Zhu, Lei Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00997-7

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1 – Tong Zhang, Linchong Sun, Yijie Hao, Caixia Suo, Shengqi Shen, Haoran Wei, Wenhao Ma, Pinggen Zhang, Ting Wang, Xuemei Gu, Shi-Ting Li, Zhaolin Chen, Ronghui Yan, Yi Zhang, Yongping Cai, Rongbin Zhou, Weidong Jia, Fang Huang, Ping Gao and Huafeng Zhang. https://www.nature.com/articles/s43018-021-00299-1

Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer – Nikita Sushentsev, Mary A. McLean and Ferdia A. Gallagher. https://www.nature.com/articles/s41467-022-28069-2

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells – Arin B. Aurora, Vishal Khivansara, Ashley Leach, Jennifer G. Gill, Misty Martin-Sandoval, Chendong Yang, Stacy Y. Kasitinon, Divya Bezwada, Alpaslan Tasdogan, Wen Gu, Thomas P. Mathews, Zhiyu Zhao, Ralph J. DeBerardinis, and Sean J. Morrison. https://www.pnas.org/content/119/6/e2120617119


Amino acids


Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors – Bo-Hyun Choi, Vipin Rawat, Jenny Högström, Philippa A. Burns, Kelly O. Conger, Mete Emir Ozgurses, Jaymin M. Patel, Tejas S. Mehta, Angelica Warren, Laura M. Selfors, Taru Muranen, Jonathan L. Coloff. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01793-9

Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions – Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00031-6


Lipids and cancer


Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity – Yanping Wang, Sungyong You, Shengchen Su, Austin Yeon, Eric M. Lo, Sungjin Kim, James L. Mohler, Michael R. Freeman and Hyung L. Kim. https://clincancerres.aacrjournals.org/content/28/2/414

MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation – Ting Zhang, Yanan Zhang, Jie Liu, Yan Ma, Qinong Ye, Xinlong Yan and Lihua Ding. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00276-3

C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer – Xiao-Zheng Liu, Anastasiia Rulina and Nils Halberg. https://www.nature.com/articles/s41467-021-27734-2

Lipidomic profiling of human serum enables detection of pancreatic cancer – Denise Wolrab, Robert Jirásko, Eva Cífková, Marcus Höring, Ding Mei, Michaela Chocholoušková, Ondřej Peterka, Jakub Idkowiak, Tereza Hrnčiarová, Ladislav Kuchař, Robert Ahrends, Radana Brumarová, David Friedecký, Gabriel Vivo-Truyols, Pavel Škrha, Jan Škrha, Radek Kučera, Bohuslav Melichar, Gerhard Liebisch, Ralph Burkhardt, Markus R. Wenk, Amaury Cazenave-Gassiot, Petr Karásek, Ivo Novotný, Kristína Greplová, Roman Hrstka and Michal Holčapek. https://www.nature.com/articles/s41467-021-27765-9

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis – Guangxi Wang, Mantang Qiu, Xudong Xing, Juntuo Zhou, Hantao Yao, Mingru Li, Rong Yin, Yan Hou, Yang Li, Shuli Pan, Yuqing Huang, Fan Yang, Fan Bai, Honggang Nie, Shuangshuang Di, Limei Guo, Zhu Meng, Jun Wang, Yuxin Yin. https://www.science.org/doi/abs/10.1126/scitranslmed.abk2756


Nucleotides


Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance – Gabriel Therizols, Zeina Bash-Imam, Baptiste Panthu, Christelle Machon, Anne Vincent, Julie Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, Maxime Garcia, Florian Laforêts, Virginie Marcel, Jihane Boubaker-Vitre, Marie-Ambre Monet, Céline Bouclier, Christophe Vanbelle, Guillaume Souahlia, Elise Berthel, Marie Alexandra Albaret, Hichem C. Mertani, Michel Prudhomme, Martin Bertrand, Alexandre David, Jean-Christophe Saurin, Philippe Bouvet, Eric Rivals, Théophile Ohlmann, Jérôme Guitton, Nicole Dalla Venezia, Julie Pannequin, Frédéric Catez and Jean-Jacques Diaz. https://www.nature.com/articles/s41467-021-27847-8


Mitochondria


Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism – Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex von Kriegsheim, Christian Frezza. https://elifesciences.org/articles/72593

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases – Esther P. Jane, Daniel R. Premkumar, Dhivyaa Rajasundaram, Swetha Thambireddy, Matthew C. Reslink, Sameer Agnihotri, Ian F. Pollack. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13025


Starvation


Leucine retention in lysosomes is regulated by starvation – Urmi Bandyopadhyay, Pavlina Todorova, Natalya N. Pavlova, Yuma Tada, Craig B. Thompson, Lydia W.S. Finley, and Michael Overholtzer. https://www.pnas.org/content/119/6/e2114912119

Endosomal cargo recycling mediated by Gpa1 and  Phosphatidylinositol-3-Kinase is inhibited by glucose starvation – Kamilla ME. Laidlaw, Katherine M. Paine, Daniel D. Bisinski, Grant Calder, Karen Hogg, Sophia Ahmed, Sally James, Peter J. O’Toole, and Chris MacDonald. https://www.molbiolcell.org/doi/10.1091/mbc.E21-04-0163?ai=25zg&ui=2oy6&af=T

The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress – Luyun Zou, Helen E Collins, Martin E Young, Jianhua Zhang, Adam R Wende, Victor M Darley-Usmar, John C Chatham.. https://www.frontiersin.org/articles/10.3389/fmolb.2021.780865/full


Hypoxia


Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions – Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00031-6

Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity – Brijesh Kumar, Adedeji K. Adebayo, Mayuri Prasad, Maegan L. Capitano, Ruizhong Wang, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Edward Simpson, Duojiao Chen, Yunlong Liu, Jeanne M. Schilder, Austyn B. Colter, Callista Maguire, Constance J. Temm, George Sandusky, Emma H. Doud, Aruna B. Wijeratne, Amber L. Mosley, Hal E. Broxmeyer, Harikrishna Nakshatri. https://www.science.org/doi/full/10.1126/sciadv.abh3375

Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers – Jialing Shen, Chunxue Yang, Misty Shuo Zhang, Don Wai-Ching Chin, For-Fan Chan, Cheuk-Ting Law, Gengchao Wang, Carol Lai-Hung Cheng, Mengnuo Chen, Rebecca Ting-Chi Wan, Mengjie Wu, Zhijian Kuang, Rakesh Sharma, Terence Kin Wah Lee, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00016-X


Cancer Immunometabolism


MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function – Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, Katherine L. Beier, Nowrin U. Chowdhury, Melissa M. Wolf, Arissa C. Young, Dalton L. Greenwood, Allison E. Sewell, Shailesh K. Shahi, Samantha N. Freedman, Alanna M. Cameron, Patrik Foerch, Tim Bourne, Juan C. Garcia-Canaveras, John Karijolich, Dawn C. Newcomb, Ashutosh K. Mangalam, Joshua D. Rabinowitz, Jeffrey C. Rathmell. https://www.cell.com/immunity/fulltext/S1074-7613(21)00448-9

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function – Lydia Dyck,  Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk, Roisin M. Loftus, Aaron Douglas, Janet McCormack, Bruce Moran, Michael Wilkinson, Evanna L. Mills, Michael Doughty, Aurelie Fabre, Helen Heneghan, Carel LeRoux, Andrew Hogan, Edward T. Chouchani, Donal O’Shea, Donal Brennan, Lydia Lynch. https://rupress.org/jem/article/219/3/e20210042/212992


Fasting


Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer – Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimondi, Darawan Rinchai, Gianmaria Frigè, Antonino Belfiore, Luca Lalli, Claudia Chiodoni, Valeria Cancila, Federica Zanardi, Arta Ajazi, Salvatore Cortellino, Viviana Vallacchi, Paola Squarcina, Agata Cova, Samantha Pesce, Paola Frati, Raghvendra Mall, Paola Antonia Corsetto, Angela Maria Rizzo, Cristina Ferraris, Secondo Folli, Marina Chiara Garassino, Giuseppe Capri, Giulia Bianchi, Mario Paolo Colombo, Saverio Minucci, Marco Foiani, Valter Daniel Longo, Giovanni Apolone, Valter Torri, Giancarlo Pruneri, Davide Bedognetti, Licia Rivoltini and Filippo de Braud. https://cancerdiscovery.aacrjournals.org/content/12/1/90

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism – Jelena Krstic, Isabel Reinisch, Katharina Schindlmaier, Markus Galhuber, Zina Riahi, Natascha Berger, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Helene Michenthaler, Christoph Nössing, Maria R. Depaoli, Jeta Ramadani-Muja, Sinem Usluer, Sarah Stryeck, Martin Pichler, Beate Rinner, Alexander J. A. Deutsch, Andreas Reinisch, Tobias Madl, Riccardo Zenezini Chiozzi, Albert J. R. Heck, Meritxell Huch, Roland Malli, Andreas Prokesch. https://www.science.org/doi/full/10.1126/sciadv.abh2635


Miscellaneous


Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors – Rupsa Datta, Sharanya Sivanand, Allison N. Lau, Logan V. Florek, Anna M. Barbeau, Jeffrey Wyckoff, Melissa C. Skala, Matthew G. Vander Heiden. https://www.science.org/doi/full/10.1126/sciadv.abg6383

Mitochondria shed their outer membrane in response to infection-induced stress – Xianhe Li, Julian Straub, Tânia Catarina Medeiros, Chahat Mehra, Fabian den Brave, Esra Peker, Ilian Atanassov, Katharina Stillger, Jonas Benjamin Michaelis, Emma Burbridge, Colin Adrain, Christian Münch, Jan Riemer, Thomas Becker, Lena F. Pernas. https://www.science.org/doi/abs/10.1126/science.abi4343


Reviews


Hypoxia-Inducible Factors in Cancer – Laura C. Kim, and M. Celeste Simon. https://cancerres.aacrjournals.org/content/82/2/195

Understanding the role of cysteine in ferroptosis: progress & paradoxes – Carson D. Poltorack, Scott J. Dixon. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15842

Amino Acid Metabolism in Cancer Drug Resistance – Hee-Chan Yoo and Jung-Min Han. https://doi.org/10.3390/cells11010140

Metabolic adaptation of lymphocytes in immunity and disease – Nicole M. Chapman, Hongbo Chi. https://www.cell.com/immunity/fulltext/S1074-7613(21)00548-3

The assembly, regulation and function of the mitochondrial respiratory chain – Irene Vercellino & Leonid A. Sazanov. https://www.nature.com/articles/s41580-021-00415-0

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma – Gabriel Alzial, Ophelie Renoult, François Paris, Catherine Gratas, Anne Clavreul and Claire Pecqueur. https://www.nature.com/articles/s41388-021-02056-1

Circulating metabolite homeostasis achieved through mass action – Xiaoxuan Li, Sheng Hui, Emily T. Mirek, William O. Jonsson, Tracy G. Anthony, Won Dong Lee, Xianfeng Zeng, Cholsoon Jang and Joshua D. Rabinowitz. https://www.nature.com/articles/s42255-021-00517-1

Built to last: lysosome remodeling and repair in health and disease – Roberto Zoncu, Rushika M.Perera. https://www.sciencedirect.com/science/article/pii/S0962892422000010

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap – Anna Halama and Karsten Suhre. https://www.mdpi.com/2072-6694/14/3/553

Cellular senescence: all roads lead to mitochondria – Hélène Martini, João F. Passos. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16361#.Yfhngl2bq4U


Comments


Metabolic transitions – Anna Dart. https://www.nature.com/articles/s41568-021-00438-x

Shifting acetylation during starvation – Wei Wong. https://www.science.org/doi/full/10.1126/scisignal.abo1065

Pentose phosphate pathway drives vascular maturation – Olga A. Cherepanova and Tatiana V. Byzova. https://www.nature.com/articles/s42255-021-00512-6

Tumor-Secreted Lipids Induce ER Stress Response to Polarize Macrophageshttps://cancerdiscovery.aacrjournals.org/content/12/1/OF5

MetaboList – December 2021


Glycolysis and the PPP


Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis – Yangmiao Duan, Jingyi Li, Fengqin Wang, Junmin Wei, Zhongfa Yang, Mingxin Sun, Jia Liu, Mingxin Wen, Wan Huang, Zhinan Chen, Zhimin Lu, Jing-Hua Yang, Guangwei Wei. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01633-8

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis – Mi Kyung Park, Li Zhang, Kyung-Won Min, Jung-Hyun Cho, Chih-Chen Yeh, Hyesu Moon, Daniel Hormaechea-Agulla, Hyejin Mun, Seungbeom Ko, Ji Won Lee, Sonali Jathar, Aubrey S. Smith, Yixin Yao, Nguyen Thu Giang, Hong Ha Vu, Victoria C. Yan, Mary C. Bridges, Antonis Kourtidis, Florian Muller, Jeong Ho Chang, Su Jung Song, Shinichi Nakagawa, Tetsuro Hirose, Je-Hyun Yoon, Min Sup Song. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00539-8

Structure and mechanism of the SGLT family of glucose transporters – Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J. Robertson, Yan Xu, Ron O. Dror, Georgios Skiniotis and Liang Feng. https://www.nature.com/articles/s41586-021-04211-w

Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin – Daniela Šimčíková, Dominik Gardáš, Kateřina Hložková, Martin Hruda, Petr Žáček, Lukáš Rob and Petr Heneberg. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00277-2

Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis – Shuyu Yu, Weicheng Zang, Yuchong Qiu, Liming Liao and Xiaofeng Zheng. https://www.nature.com/articles/s41388-021-02071-2

NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma – Zhuolin Li, Yuxin He, Yanjun Li, Juan Li, Hezhao Zhao, Guanbing Song, Makoto Miyagishi, Shourong Wu and Vivi Kasim. https://www.nature.com/articles/s41388-021-02063-2


Hexosamines


Glutamine deprivation triggers NAGK-dependent hexosamine salvage – Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen. https://elifesciences.org/articles/62644

Hyaluronic acid fuels pancreatic cancer cell growth – Peter K Kim, Christopher J Halbrook, Samuel A Kerk, Megan Radyk, Stephanie Wisner, Daniel M Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D Welling, Li Zhang, Matthew R Pratt, Kayvan R Keshari, Haoqiang Ying, Costas A Lyssiotis. https://elifesciences.org/articles/62645


Amino acids/Urea


Valine tRNA levels and availability regulate complex I assembly in leukaemia – Palaniraja Thandapani, Andreas Kloetgen, Matthew T. Witkowski, Christina Glytsou, Anna K. Lee, Eric Wang, Jingjing Wang, Sarah E. LeBoeuf, Kleopatra Avrampou, Thales Papagiannakopoulos, Aristotelis Tsirigos and Iannis Aifantis. https://www.nature.com/articles/s41586-021-04244-1

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism – Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith and M. Celeste Simon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00271-8

Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells – Peter F. Doubleday, Luca Fornelli, Ioanna Ntai, Neil L. Kelleher. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16111


Lipid metabolism


The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes – Lacroix M, Linares LK, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, Fau C, Gayte L, Blanchet E, Mairal A, Derua R, Cardona F, Beuzelin D, Annicotte JS, Pirot N, Torro A, Tinahones FJ, Bernex F, Bertrand-Michel J, Langin D, Fajas L, Swinnen JV, Le Cam L. https://www.nature.com/articles/s41467-021-27307-3

Induction of SREBP1 degradation coupled with suppression of SREBP1-mediated lipogenesis impacts the response of EGFR mutant NSCLC cells to osimertinib – Zhen Chen, Danlei Yu, Taofeek K. Owonikoko, Suresh S. Ramalingam and Shi-Yong Sun. https://www.nature.com/articles/s41388-021-02057-0

NAD kinase sustains lipogenesis and mitochondrial metabolism through fatty acid synthesis – Mengyao Xu, Long Ding, Jingjing Liang, Xiao Yang, Yuan Liu, Yingchun Wang, Mei Ding, Xun Huang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01653-3?


Mitochondria


AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia – Adrien Grenier, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, Clement Larrue, Ambrine Sahal, Rudy Birsen, Victoria Ghesquier, Justine Decroocq, Fetta Mazed, Mireille Lambert, Mamy Andrianteranagna, Benoit Viollet, Patrick Auberger, Andrew A. Lane, Pierre Sujobert, Didier Bouscary, Jean-Emmanuel Sarry, Jerome Tamburini. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01701-0

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis – Divya Ramchandani, Mirela Berisa, Diamile A. Tavarez, Zhuoning Li, Matthew Miele, Yang Bai, Sharrell B. Lee, Yi Ban, Noah Dephoure, Ronald C. Hendrickson, Suzanne M. Cloonan, Dingcheng Gao, Justin R. Cross, Linda T. Vahdat and Vivek Mittal. https://www.nature.com/articles/s41467-021-27559-z

Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect – Jianong Zhang, Liang Zhang, Ji Nie, Yan Lin, Yao Li, Wei Xu, Jian-Yuan Zhao, Shi-Min Zhao & Chenji Wang. https://www.nature.com/articles/s41388-021-02065-0

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen – Mara Mennuni, Roberta Filograna, Andrea Felser, Nina A Bonekamp, Patrick Giavalisco, Oleksandr Lytovchenko, Nils-Göran Larsson. https://www.embopress.org/doi/full/10.15252/embr.202153054


Starvation


Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes – Wen-Chuan Hsieh, Benjamin M. Sutter, Holly Ruess, Spencer D. Barnes, Venkat S. Malladi, Benjamin P. Tu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01077-7

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis – Lianggong Ding, Wenfei Sun, Miroslav Balaz, Anyuan He, Manuel Klug, Stefan Wieland, Robert Caiazzo, Violeta Raverdy, Francois Pattou, Philippe Lefebvre, Irfan J. Lodhi, Bart Staels, Markus Heim and Christian Wolfrum. https://www.nature.com/articles/s42255-021-00489-2

Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis – Hyeon-Ok Jin, Sung-Eun Hong, Ji-Young Kim, Se-Kyeong Jang and In-Chul Park. https://www.nature.com/articles/s41419-021-04417-w


Cancer Immunometabolism


Coenzyme A fuels T cell anti-tumor immunity – Michael St. Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Céline Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, Pamela S. Ohashi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00538-6

Macrophages are metabolically heterogeneous within the tumor microenvironment – Xenia Geeraerts, Juan Fernández-Garcia, Felix J. Hartmann, Kyra E. de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C. Bendall, Damya Laoui, Jan Van den Bossche, Sarah-Maria Fendt, Jo A. Van Ginderachter. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01671-5

A purine metabolic checkpoint that prevents autoimmunity and autoinflammation – Svetlana Saveljeva, Gavin W. Sewell, Katharina Ramshorn, M. Zaeem Cader, James A. West, Simon Clare, Lea-Maxie Haag, Rodrigo Pereira de Almeida Rodrigues, Lukas W. Unger, Ana Belén Iglesias-Romero, Lorraine M. Holland, Christophe Bourges, Muhammad N. Md-Ibrahim, James O. Jones, Richard S. Blumberg, James C. Lee, Nicole C. Kaneider, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Arthur Kaser. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00628-8


Miscellaneous


Metabolic drug survey highlights cancer cell dependencies and vulnerabilities – Tea Pemovska, Johannes W. Bigenzahn, Ismet Srndic, Alexander Lercher, Andreas Bergthaler, Adrián César-Razquin, Felix Kartnig, Christoph Kornauth, Peter Valent, Philipp B. Staber and Giulio Superti-Furga. https://www.nature.com/articles/s41467-021-27329-x

Screening human lung cancer with predictive models of serum magnetic resonance spectroscopy metabolomics – Tjada A. Schult, Mara J. Lauer, Yannick Berker, Marcella R. Cardoso, Lindsey A. Vandergrift, Piet Habbel, Johannes Nowak, Matthias Taupitz, Martin Aryee, Mari A. Mino-Kenudson, David C. Christiani, and Leo L. Cheng. https://www.pnas.org/content/118/51/e2110633118.abstract?etoc

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness – Pravat Kumar Parida, Mauricio Marquez-Palencia, Vidhya Nair, Akash K. Kaushik, Kangsan Kim, Jessica Sudderth, Eduardo Quesada-Diaz, Ambar Cajigas, Vamsidhara Vemireddy, Paula I. Gonzalez-Ericsson, Melinda E. Sanders, Bret C. Mobley, Kenneth Huffman, Sunati Sahoo, Prasanna Alluri, Cheryl Lewis, Yan Peng, Robert M. Bachoo, Carlos L. Arteaga, Ariella B. Hanker, Ralph J. DeBerardinis, Srinivas Malladi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00620-3


Reviews


Targeting cancer metabolism in the era of precision oncology – Zachary E. Stine, Zachary T. Schug, Joseph M. Salvino and Chi V. Dang. https://www.nature.com/articles/s41573-021-00339-6

The N-terminal cysteine is a dual sensor of oxygen and oxidative stress – Ah Jung Heo, Su Bin Kim, Chang Hoon Ji, Dohyun Han, Su Jin Lee, Su Hyun Lee, Min Ju Lee, Ji Su Lee, Aaron Ciechanover, Bo Yeon Kim, and Yong Tae Kwon – https://www.pnas.org/content/118/50/e2107993118.abstract?etoc

Revisiting the HIF switch in the tumor and its immune microenvironment – Sophie J. Cowman, Mei Yee Koh. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00209-0

Molecular aspects of fructose metabolism and metabolic disease – Mark A. Herman, Morris J. Birnbaum. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00429-0

“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis – Mark A. Febbraio, Michael Karin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00423-X


Comments


Dinner is served, sir: Fighting cancer with the right diet – Andrés Méndez-Lucas, Mariia Yuneva. https://www.cell.com/cell/fulltext/S0092-8674(21)01386-6

CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way – Ameeta Kelekar, Stephen C. Jameson. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00537-4

MetaboList – November 2021


Mitochondria and ROS


Fumarate is a terminal electron acceptor in the mammalian electron transport chain – Jessica B. Spinelli, Paul C. Rosen, Hans-Georg Sprenger, Anna M. Puszynska, Jessica L. Mann, Julian M. Roessler, Andrew L. Cangelosi, Antonia Henne, Kendall J. Condon, Tong Zhang, Tenzin Kunchok, Caroline A. Lewis, Navdeep S. Chandel, David M. Sabatini. https://www.science.org/doi/10.1126/science.abi7495
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment – Simon Schwörer, Natalya N. Pavlova, Francesco V. Cimino, Bryan King, Xin Cai, Gina M. Sizemore and Craig B. Thompson. https://www.nature.com/articles/s42255-021-00480-x
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth – Nancy P Echeverri Ruiz, Vijay Mohan, Jinghai Wu, Sabina Scott, McKenzie Kreamer, Martin Benej, Tereza Golias, Ioanna Papandreou, Nicholas C Denko. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00275-4
Riboflavin transporter SLC52A1, a target of p53, suppresses cellular senescence by activating mitochondrial complex II – Taiki Nagano, Yuto Awai, Shione Kuwaba, Taiichi Osumi, Kentaro Mio,  Tetsushi Iwasaki, and Shinji Kamada. https://www.molbiolcell.org/doi/10.1091/mbc.E21-05-0262?ai=s5&ui=2oy6&af=T
Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants – Alisha G. Lewis, Robert Caldwell, Jason V. Rogers, Maria Ingaramo, Rebecca Y. Wang, Ilya Soifer, David G. Hendrickson, R. Scott McIsaac, David Botstein, and Patrick A. Gibney. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E21-06-0314
SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer – Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia, Shiqi Liu, Tao Wu, Xianli He and Nan Wang. https://www.nature.com/articles/s41419-021-04411-2
Molecular characteristics and tumorigenicity of ascites‐derived tumor cells: mitochondrial oxidative phosphorylation as a novel therapy target in ovarian cancer – Yi Ding, Vera Labitzky, Karen Legler, Minyue Qi, Udo Schumacher, Barbara Schmalfeldt, Christine Stürken, Leticia Oliveira-Ferrer. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13028

YAP1-mediated regulation of mitochondrial dynamics in IDH1 mutant gliomas – Shruti Patrick, Pruthvi Gowda, Kirti Lathoria, Vaishali Suri, Ellora Sen. https://journals.biologists.com/jcs/article-abstract/134/22/jcs259188/273515

Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia – Claudie Bosc, Estelle Saland, Aurélie Bousard, Noémie Gadaud, Marie Sabatier, Guillaume Cognet, Thomas Farge, Emeline Boet, Mathilde Gotanègre, Nesrine Aroua, Pierre-Luc Mouchel, Nathaniel Polley, Clément Larrue, Eléonore Kaphan, Muriel Picard, Ambrine Sahal, Latifa Jarrou, Marie Tosolini, Florian Rambow, Florence Cabon, Nathalie Nicot, Laura Poillet-Perez, Yujue Wang, Xiaoyang Su, Quentin Fovez, Jérôme Kluza, Rafael José Argüello, Céline Mazzotti, Hervé Avet-Loiseau, François Vergez, Jérôme Tamburini, Jean-Jacques Fournié, Ing S. Tiong, Andrew H. Wei, Tony Kaoma, Jean-Christophe Marine, Christian Récher, Lucille Stuani, Carine Joffre and Jean-Emmanuel Sarry
https://www.nature.com/articles/s43018-021-00264-y


Lipid metabolism


Dietary palmitic acid promotes a prometastatic memory via Schwann cells – Gloria Pascual, Diana Domínguez, Marc Elosúa-Bayes, Felipe Beckedorff, Carmelo Laudanna, Claudia Bigas, Delphine Douillet, Carolina Greco, Aikaterini Symeonidi, Inmaculada Hernández, Sara Ruiz Gil, Neus Prats, Coro Bescós, Ramin Shiekhattar, Moran Amit, Holger Heyn, Ali Shilatifard and Salvador Aznar Benitah. https://www.nature.com/articles/s41586-021-04075-0
Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis – Madeleine Dorsch, Manuela Kowalczyk, Mélanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T. Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T. Siveke, Monte M. Winslow, Sarah-Maria Fendt, Perihan Nalbant, Barbara M. Grüner. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01542-4

Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma – Romain Riscal, Caroline J. Bull, Clementina Mesaros, Jennifer M. Finan, Madeleine Carens, Elaine S. Ho, Jimmy P. Xu, Jason Godfrey, Paul Brennan, Mattias Johansson, Mark P. Purdue, Stephen J. Chanock, Daniela Mariosa, Nicholas J. Timpson, Emma E. Vincent, Brian Keith, Ian A. Blair, Nicolas Skuli and M. Celeste Simon. https://cancerdiscovery.aacrjournals.org/content/11/12/3106
Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity – Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford and Suzana D. Savkovic. https://www.nature.com/articles/s41389-021-00373-4

iRGD‐modified exosomes effectively deliver CPT1A siRNA to colon cancer cells, reversing oxaliplatin resistance by regulating fatty acid oxidation – Dan Lin, Haiyang Zhang, Rui Liu, Ting Deng, Tao Ning, Ming Bai, Yuchong Yang, Kegan Zhu, Junyi Wang, Jingjing Duan, Shaohua Ge, Bei Sun, Guoguang Ying, Yi Ba. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13052

Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathway – Ming-Da Wang, Nan-Ya Wang, Hui-Lu Zhang, Li-Yang Sun, Qiu-Ran Xu, Lei Liang, Chao Li, Dong-Sheng Huang, Hong Zhu and Tian Yang. https://www.nature.com/articles/s41389-021-00364-5


Starvation


CARS senses cysteine deprivation to activate AMPK for cell survival – Mengqiu Yuan, Ronghui Yan, Yi Zhang, Yue Qiu, Zetan Jiang, Haiying Liu, Ying Wang, Linchong Sun, Huafeng Zhang, Ping Gao. https://www.embopress.org/doi/abs/10.15252/embj.2021108028
Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux – Keren E. Shapira, Guy Shapira, Eran Schmukler, Metsada Pasmanik-Chor, Noam Shomron, Ronit Pinkas-Kramarski, Yoav I. Henis and Marcelo Ehrlich. https://www.nature.com/articles/s41420-021-00718-3

Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis – Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, Oumaima Ahmed, Clémence Messmer, Nazar Mashtalir, Haithem Barbour, Louis Masclef, Marion Voide, Claire Viallard, Salima Daou, Djaileb Abdelhadi, Daryl Ronato, Mohammadjavad Paydar, Anaïs Darracq, Karine Boulay, Nicolas Desjardins-Lecavalier, Przemyslaw Sapieha, Jean-Yves Masson, Mikhail Sergeev, Benjamin H. Kwok, Laura Hulea, Frédérick A. Mallette, Eric Milot, Bruno Larrivée, Hugo Wurtele and El Bachir Affar. https://www.nature.com/articles/s41467-021-27306-4

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape – Giulia Salvadori, Federica Zanardi, Fabio Iannelli, Riccardo Lobefaro, Claudio Vernieri, Valter D. Longo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00486-1


mTOR and nutrient sensing


The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity – Pedro Fuentes, Joffrey Pelletier, Carolina Martinez-Herráez, Virginia Diez-Obrero, Flavia Iannizzotto, Teresa Rubio, Marta Garcia-Cajide, Sandra Menoyo, Victor Moreno, Ramón Salazar, Albert Tauler, Antonio Gentilella. https://www.science.org/doi/full/10.1126/sciadv.abg9275
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis – Motohiro Sekiya, Kenta Kainoh, Takehito Sugasawa, Ryunosuke Yoshino, Takatsugu Hirokawa, Hiroaki Tokiwa, Shogo Nakano, Satoru Nagatoishi, Kouhei Tsumoto, Yoshinori Takeuchi, Takafumi Miyamoto, Takashi Matsuzaka and Hitoshi Shimano. https://www.nature.com/articles/s41467-021-26638-5

AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake – Xi Sheng Rao, Xiao Xia Cong, Xiu Kui Gao, Yin Pu Shi, Lin Jing Shi, Jian Feng Wang, Chen-Yao Ni, Ming Jie He, Yingke Xu, Cong Yi, Zhuo-Xian Meng, Jinling Liu, Peng Lin, Li Ling Zheng and Yi Ting Zhou. https://www.nature.com/articles/s41418-021-00809-9


Glucose metabolism


Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition – Hongyu Ding, Zihong Chen , Katherine Wu, Shih Ming Huang, Warren L Wu, Sarah E LeBoeuf, Ray G Pillai , Joshua D Rabinowitz, Thales Papagiannakopoulos. https://www.science.org/doi/10.1126/sciadv.abk1023
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets – Accalia Fu, Lara van Rooyen, Lindsay Evans, Nina Armstrong, Daina Avizonis, Tatsuya Kin, Gregory H. Bird, Anita Reddy, Edward T. Chouchani, Marc Liesa-Roig, Loren D. Walensky, A.M. James Shapiro, Nika N. Danial. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01519-9

Detection of glucose-derived D- and L-lactate in cancer cells by the use of a chiral NMR shift reagent – Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis and A. Dean Sherry. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00267-4
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2 – Tianshui Sun, Zhuonan Liu, Fangfang Bi, Qing Yang. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13076

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain – Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson and Matthew J. A. Wood. https://www.nature.com/articles/s41467-021-27056-3

A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma – Corinne Beinat, Chirag B. Patel, Tom Haywood, Surya Murty, Lewis Naya, Jessa B. Castillo, Samantha T. Reyes, Megan Phillips, Pablo Buccino, Bin Shen, Jun Hyung Park, Mary Ellen I. Koran, Israt S. Alam, Michelle L. James, Dawn Holley, Kim Halbert, Harsh Gandhi, Joy Q. He, Monica Granucci, Eli Johnson, Daniel Dan Liu, Nobuko Uchida, Rahul Sinha, Pauline Chu, Donald E. Born, Geoffrey I. Warnock, Irving Weissman, Melanie Hayden-Gephart, Mehdi Khalighi, Tarik F. Massoud, Andrei Iagaru, Guido Davidzon, Reena Thomas, Seema Nagpal, Lawrence D. Recht and Sanjiv Sam Gambhir. https://clincancerres.aacrjournals.org/content/27/23/6467


Amino acids


The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases – Rossella Marullo, Monica Castro, Shira Yomtoubian, M. Nieves Calvo-Vidal, Maria Victoria Revuelta, Jan Krumsiek, Andrew Cho, Pablo Cresta Morgado, ShaoNing Yang, Vanina Medina, Berta M. Roth, Marcelo Bonomi, Kayvan R. Keshari, Vivek Mittal, Alfredo Navigante, Leandro Cerchietti. https://www.science.org/doi/full/10.1126/sciadv.abg1964

Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis – Sabarish Ramachandran, Souad R. Sennoune, Monica Sharma, Muthusamy Thangaraju, Varshini V. Suresh, Tyler Sneigowski, Yangzom D. Bhutia, Kevin Pruitt, Vadivel Ganapathy. https://portlandpress.com/biochemj/article/478/21/3957/230003
Methionine synthase is essential for cancer cell proliferation in physiological folate environments – Mark R. Sullivan, Alicia M. Darnell, Montana F. Reilly, Tenzin Kunchok, Lena Joesch-Cohen, Daniel Rosenberg, Ahmed Ali, Matthew G. Rees, Jennifer A. Roth, Caroline A. Lewis and Matthew G. Vander Heiden. https://www.nature.com/articles/s42255-021-00486-5
Methionine synthase supports tumour tetrahydrofolate pools – Jonathan M. Ghergurovich, Xincheng Xu, Joshua Z. Wang, Lifeng Yang, Rolf-Peter Ryseck, Lin Wang and Joshua D. Rabinowitz. https://www.nature.com/articles/s42255-021-00465-w


Nucleotides and NAD


A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer – Jin Lee, Xiaoxi Chen, Yuming Wang, Tatsunori Nishimura, Mengjiao Li, Satoko Ishikawa, Takiko Daikoku, Junya Kawai, Arinobu Tojo, Noriko Gotoh. https://www.sciencedirect.com/science/article/pii/S0006291X2101500X
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells – Ellen Tully, Santosh Bharti, Juhyung Woo, Zaver Bhujwalla, Edward Gabrielson. https://www.tandfonline.com/doi/abs/10.1080/15384047.2021.1982599

LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway – Fengyu Xu, Mengqi Huang, Qingyong Chen, Yi Niu, Yuhang Hu, Ping Hu, Ding Chen, Chi He, Kang Huang, Zhu Zeng, Jiang Tang, Fan Wang, Yong Zhao, Chunyou Wang and Gang Zhao. https://cancerres.aacrjournals.org/content/81/22/567
Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer – Marie Malier, Khaldoun Gharzeddine, Marie-Hélène Laverriere, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth and Arnaud Millet. https://cancerres.aacrjournals.org/content/81/23/5963


Cancer Immunometabolism


Lactate supports a metabolic-epigenetic link in macrophage polarization – Jordan T. Noe, Beatriz E. Rendon, Anne E. Geller, Lindsey R. Conroy, Samantha M. Morrissey, Lyndsay E.A. Young, Ronald C. Bruntz, Eun J. Kim, Ashley Wise-Mitchell, Mariana Barbosa de Souza Rizzo, Eric R. Relich, Becca V. Baby, Lance A. Johnson, Hayley C. Affronti, Kelly M. McMasters, Brian F. Clem, Matthew S. Gentry, Jun Yan, Kathryn E. Wellen, Ramon C. Sun, Robert A. Mitchell. https://www.science.org/doi/full/10.1126/sciadv.abi8602

Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis – Maria I. Matias, Carmen S. Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R. Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C. Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S. Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V. Swinnen, Stefan A. Muljo, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01384-X
Manipulation of epithelial-to-mesenchymal transition reveals metastatic breast cancers support immune suppression via heme metabolism – Michelle Williams, Sabrina Hafeez, Jessica Christenson, Nicole Spoelstra, Jill Slansky and Jennifer Richer. https://jitc.bmj.com/content/9/Suppl_2/A933
Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma – Lijie Zhai, April Bell, Erik Ladomersky, Kristen L. Lauing, Lakshmi Bollu, Brenda Nguyen, Matthew Genet, Miri Kim, Peiwen Chen, Xinlei Mi, Jennifer D. Wu, Matthew J. Schipma, Brian Wray, John Griffiths, Richard D. Unwin, Simon J. Clark, Rajesh Acharya, Riyue Bao, Craig Horbinski, Rimas V. Lukas, Gary E. Schiltz and Derek A. Wainwright. https://clincancerres.aacrjournals.org/content/27/23/651


Reviews


Tumour fatty acid metabolism in the context of therapy resistance and obesity – Andrew J. Hoy, Shilpa R. Nagarajan and Lisa M. Butler. https://www.nature.com/articles/s41568-021-00388-4

Compartmentalization and metabolic regulation of glycolysis – Gregory G. Fuller, John K. Kim. https://journals.biologists.com/jcs/article-abstract/134/20/jcs258469/272535
Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited – Chenfeng Han, Minmin Ge, Ping-Chih Ho and Lianjun Zhang. https://cancerimmunolres.aacrjournals.org/content/early/2021/10/29/2326-6066.CIR-21-0459
The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment – Maria Iorio, Nikkitha Umesh Ganesh, Monica De Luise, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac. https://www.mdpi.com/2072-6694/13/21/5447
Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function – Lídia Fortuny and Carlos Sebastián. https://www.mdpi.com/2073-4425/12/11/1698
The Key Role of the WNT/β-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions – Alexandre Vallée, Yves Lecarpentier, Jean-Noël Vallée. https://pubmed.ncbi.nlm.nih.gov/34771718/


Comments / other


Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer – Ali Khateb, Ze’ev A Ronai. https://www.embopress.org/doi/abs/10.15252/embj.2021109683
Mitochondria-More than just ATP for CTLs – Jonathan S. Maltzman. https://www.science.org/doi/full/10.1126/sciimmunol.eabn0249

Upcycling the TCA cycle—rewiring tumour-associated fibroblasts – Zachary A. Bacigalupa & W. Kimryn Rathmell. https://www.nature.com/articles/s42255-021-00473-w
A new foe in folate metabolism – Zhengwei Wu and Wai Leong Tam. https://www.nature.com/articles/s42255-021-00474-9
AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation – Cansu Karabiyik and David C. Rubinsztein
https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1961409
AMPK CA(R)Sts a new light on amino acid sensing – Kristin K Brown. https://www.embopress.org/doi/abs/10.15252/embj.2021109575

Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization – Anna Mukha, Uğur Kahya and Anna Dubrovska. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1962682

MetaboList – October 2021


Diet and cancer


Low glycaemic diets alter lipid metabolism to influence tumour growth – Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin and Matthew G. Vander Heiden. https://www.nature.com/articles/s41586-021-04049-2

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition – Laura C. D. Pomatto-Watson, Monica Bodogai, Oye Bosompra, Jonathan Kato, Sarah Wong, Melissa Carpenter, Eleonora Duregon, Dolly Chowdhury, Priya Krishna, Sandy Ng, Emeline Ragonnaud, Roberto Salgado, Paula Gonzalez Ericsson, Alberto Diaz-Ruiz, Michel Bernier, Nathan L. Price, Arya Biragyn, Valter D. Longo and Rafael de Cabo. https://www.nature.com/articles/s41467-021-26431-4

Megakaryocytes Mediate Hyperglycemia-Induced Tumor Metastasis – Biying Wu, Ying Ye, Sisi Xie, Yintao Li, Xiaoting Sun, Mengyuan Lv, Ling Yang, Nan Cui, Qiying Chen, Lasse D. Jensen, Dongmei Cui, Guichun Huang, Ji Zuo, Shaochong Zhang, Wen Liu and Yunlong Yang. https://cancerres.aacrjournals.org/content/81/21/5506


Mitochondrial metabolism


Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis – Kazuki Heishima, Nobuhiko Sugito, Tomoyoshi Soga, Masashi Nishikawa, Yuko Ito, Ryo Honda, Yuki Kuranaga, Hiroki Sakai, Ryo Ito, Takayuki Nakagawa, Hiroshi Ueda, and Yukihiro Akao. https://www.jci.org/articles/view/139933

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia – Victoria da Silva-Diz, Bin Cao, Olga Lancho, Eric Chiles, Amer Alasadi, Maya Aleksandrova, Shirley Luo, Amartya Singh, Hanlin Tao, David Augeri, Sonia Minuzzo, Stefano Indraccolo, Hossein Khiabanian, Xiaoyang Su, Shengkan Jin, Daniel Herranz. https://ashpublications.org/blood/article-abstract/138/15/1317/475782/A-novel-and-highly-effective-mitochondrial

Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15 – Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore and John P. Kirwan. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00274-5

Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease – Shanshan Liu, Song Fu, Guodong Wang, Yu Cao, Lanlan Li, Xuemei Li, Jun Yang, Ning Li, Yabing Shan, Yang Cao, Yan Ma, Mengqiu Dong, Qinghua Liu, Hui Jiang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00283-7

Heme sequestration effectively suppresses the development and progression of both lung adenocarcinoma and squamous cell carcinoma – Sanchareeka Dey, Adnin Ashrafi, Chantal Vidal, Nivesh Jain, Sarada Preeta Kalainayakan, Poorva Ghosh, Parinaz Sadat Alemi, Narges Salamat, Purna Chaitanya Konduri, Jung-whan Kim and Li Zhang. https://mcr.aacrjournals.org/content/early/2021/10/11/1541-7786.MCR-21-0385.long

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer – Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb A. Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek and Funda Meric-Bernstam. https://cancerres.aacrjournals.org/content/81/21/5572


Nutrient sensing / starvation / AMPK


Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1 – Mengnan Zhu, Fukang Teng, Na Li, Li Zhang, Shuxian Zhang, Fan Xu, Jing Shao, Haipeng Sun, Huanhu Zhu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00728-0

CCCP‐induced mitochondrial dysfunction – characterization and analysis of integrated stress response to cellular signaling and homeostasis – Ramagopal Reddy Koncha, Gayatri Ramachandran, Naresh Babu V. Sepuri, Kolluru V. A. Ramaiah. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15868

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly – Gea Cereghetti, Caroline Wilson-Zbinden, Vera M. Kissling, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, Paola Picotti, D. Allan Drummond, Uwe Sauer, Reinhard Dechant and Matthias Peter. https://www.nature.com/articles/s41556-021-00760-4

Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation – Jialiang Shao, Tiezhu Shi, Hua Yu, Yufeng Ding, Liping Li, Xiang Wang, Xiongjun Wang. https://www.embopress.org/doi/abs/10.15252/embj.2020107480

RIPK1 regulates starvation resistance by modulating aspartate catabolism – Xinyu Mei, Yuan Guo, Zhangdan Xie, Yedan Zhong, Xiaofen Wu, Daichao Xu, Ying Li, Nan Liu and Zheng-Jiang Zhu. https://www.nature.com/articles/s41467-021-26423-4

Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase – Ben Zhou, Yuyao Zhang, Sainan Li, Lianfeng Wu, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Alexander A. Soukas. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01244-4


Cancer Immunometabolism


Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity – Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart-Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, Xiaoyun Li, Zhengtao Xiao, Lydia N. Raines, Maryline Falquet, Antoine Jalil, Jason W. Locasale, Piergiorgio Percipalle, David Masson, Stanley Ching-Cheng Huang, Fabio Martinon, Julijana Ivanisevic and Ping-Chih Ho. https://www.nature.com/articles/s41590-021-01047-4

Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress – Lisa Holthaus, Virag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, Ezio Bonifacio. https://www.life-science-alliance.org/content/4/12/e202101013

Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP–Mediated Mitochondrial Dysfunction – Rong Jin, Jiaqing Hao, Yanmei Yi, Di Yin, Yuan Hua, Xiaohong Li, Hanmei Bao, Xianlin Han, Nejat K. Egilmez, Edward R. Sauter and Bing Li. https://cancerres.aacrjournals.org/content/81/20/5296

Macrophage-Derived Cholesterol Contributes to Therapeutic Resistance in Prostate Cancer – Asmaa El-Kenawi, William Dominguez-Viqueira, Min Liu, Shivanshu Awasthi, Julieta Abraham-Miranda, Aysenur Keske, KayLee K. Steiner, Leenil Noel, Amparo N. Serna, Jasreman Dhillon, Robert J. Gillies, Xiaoqing Yu, John M. Koomen, Kosj Yamoah, Robert A. Gatenby and Brian Ruffell. https://cancerres.aacrjournals.org/content/81/21/5477

Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies – Sabrina Cappello, Hsu-Min Sung, Christian Ickes, Christine S. Gibhardt, Adina Vultur, Hilal Bhat, Zhongwen Hu, Patricia Brafford, Andreas Denger, Ioana Stejerean-Todoran, Rixa-Mareike Köhn, Verena Lorenz, Nicolas Künzel, Gabriela Salinas, Hedwig Stanisz, Tobias Legler, Peter Rehling, Michael P. Schön, Karl S. Lang, Volkhard Helms, Meenhard Herlyn, Markus Hoth, Carsten Kummerow and Ivan Bogeski. https://cancerres.aacrjournals.org/content/81/21/5540

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming – Samantha M. Morrissey, Fan Zhang, Chuanlin Ding, Diego Elias Montoya-Durango, Xiaoling Hu, Chenghui Yang, Zhen Wang, Fang Yuan, Matthew Fox, Huang-ge Zhang, Haixun Guo, David Tieri, Maiying Kong, Corey T. Watson, Robert A. Mitchell, Xiang Zhang, Kelly M. McMasters, Jian Huang, Jun Yan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00421-6


Glucose metabolism


Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive hematopoietic progenitor growth – Cheuk Him Man, Francois Emile Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles Lin, Anskar YH Leung, David T Scadden. https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2021011563/477177

m6A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability – Hongjiang Liu, Shan Qin, Changqi Liu, Le Jiang, Chen Li, Jiankai Yang, Shunyao Zhang, Zhongjie Yan, Xiaopeng Liu, Jipeng Yang and Xiaofeng Sun. https://www.nature.com/articles/s41420-021-00674-y

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation – Irini Skaripa-Koukelli, David Hauton, John Walsby-Tickle, Eloïse Thomas, Joshua Owen, Abirami Lakshminarayanan, Sarah Able, James McCullagh, Robert C. Carlisle and Katherine A. Vallis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00273-6

TXNIP links anticipatory unfolded protein response to estrogen reprogramming glucose metabolism in breast cancer cells – Yuanzhong Wang, Shiuan Chen. https://doi.org/10.1210/endocr/bqab212


Cystine / Glutathione


SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells – Ying Wang, Frederick S. Yen, Xiphias Ge Zhu, Rebecca C. Timson, Ross Weber, Changrui Xing, Yuyang Liu, Benjamin Allwein, Hanzhi Luo, Hsi-Wen Yeh, Søren Heissel, Gokhan Unlu, Eric R. Gamazon, Michael G. Kharas, Richard Hite and Kıvanç Birsoy. https://www.nature.com/articles/s41586-021-04025-w

Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer – Ke-Ren Zhang, Yu-Fei Zhang, Hui-Min Lei, Ya-Bin Tang, Chun-Shuang Ma, Qian-Ming Lv, Shi-Yi Wang, Li-Ming Lu, Ying Shen, Hong-Zhuan Chen, Liang Zhu. https://www.science.org/doi/abs/10.1126/scitranslmed.abg6428

Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11 – Xinbo Wang, Yueqing Chen, Xudong Wang, Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yu’e Liu, Zhenyu Cai, Xinyuan Tong, Yi Luan, Xiao Tan, Bing Luan, Xin Ge, Hongbin Ji, Xuejun Jiang and Ping Wang. https://cancerres.aacrjournals.org/content/81/20/5217

RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11 – Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He, Luning Wang, Dan Chen, Shujun Fan, Huan Chen, Hai-Long Piao, Qinglong Qiao, Zhaochao Xu, Jinrui Zhang, Jinyao Zhao, Sirui Zhang, Yue Yin, Chao Peng, Xiaoling Li, Quentin Liu, Han Liu, Yang Wang. https://www.jci.org/articles/view/15206


Amino acid metabolism


The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells – Marc Hennequart, Christiaan F. Labuschagne, Mylène Tajan, Steven E. Pilley, Eric C. Cheung, Nathalie M. Legrave, Paul C. Driscoll and Karen H. Vousden. https://www.nature.com/articles/s41467-021-26395-5

The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress – Chunmin Ma, Ke Zheng, Kun Jiang, Qin Zhao, Nannan Sha, Wang Wang, Man Yan, Tao Chen, Yuzheng Zhao and Yuhui Jiang. https://www.nature.com/articles/s42255-021-00456-x

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1 – Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol-Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12999


Lipid metabolism


p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth – Huishan Sun, Li Li, Wei Li, Fan Yang, Zhenxi Zhang, Zizhao Liu, Wenjing Du. https://www.embopress.org/doi/abs/10.15252/embr.202152537

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer – Ser Yue Loo, Li Ping Toh, William Haowei Xie, Elina Pathak, Wilson Tan, Siming Ma, May Yin Lee, S. Shatishwaran, Joanna Zhen Zhen Yeo, Ju Yuan, Yin Ying Ho, Esther Kai Lay Peh, Magendran Muniandy, Federico Torta, Jack Chan, Tira J. Tan, Yirong Sim, Veronique Tan, Benita Tan, Preetha Madhukumar, Wei Sean Yong, Kong Wee Ong, Chow Yin Wong, Puay Hoon Tan, Yoon Sim Yap, Lih-Wen Deng, Rebecca Dent, Roger Foo, Markus R. Wenk, Soo Chin Lee, Ying Swan Ho, Elaine Hsuen Lim, Wai Leong Tam. https://www.science.org/doi/full/10.1126/sciadv.abh2443

Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC – Sagar D. Sardesai, Alexandra Thomas, Christopher Gallagher, Filipa Lynce, Yvonne Lynn Ottaviano, Tarah Jean Ballinger, Bryan P. Schneider, Anna Maria Storniolo, Amber Bauchle, Sandra K. Althouse, Susan M. Perkins, Andrea R. Masters, Robert E. Stratford Jr, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang and Kathy D. Miller. https://clincancerres.aacrjournals.org/content/27/21/5810

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells – Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez and Ruth Lupu. https://www.nature.com/articles/s41419-021-04262-x

Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements – Vasiliki Symeonidou, Hélène Jakobczyk, Salem Bashanfer, Camille Malouf, Foteini Fotopoulou, Rishi S. Kotecha, Richard A. Anderson, Andrew J. Finch, Katrin Ottersbach. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01370-X

ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells – Jillian Hattaway Luttman Jacob P. Hoj, Kevin H. Lin,  Jiaxing Lin, Jing Jin Gu,  Clay Rouse, Amanda G. Nichols, Nancie J. MacIver, Kris C. Wood, Ann Marie Pendergast. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01350-4

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma – Francesca Puca, Fei Yu, Caterina Bartolacci, Piergiorgio Pettazzoni, Alessandro Carugo, Emmet Huang-Hobbs, Jintan Liu, Ciro Zanca, Federica Carbone, Edoardo Del Poggetto, Joy Gumin, Pushan Dasgupta, Sahil Seth, Sanjana Srinivasan, Frederick F. Lang, Erik P. Sulman, Philip L. Lorenzi, Lin Tan, Mengrou Shan, Zachary P. Tolstyka, Maureen Kachman, Li Zhang, Sisi Gao, Angela K. Deem, Giannicola Genovese, Pier Paolo Scaglioni, Costas A. Lyssiotis, Andrea Viale and Giulio F. Draetta. https://cancerdiscovery.aacrjournals.org/content/11/11/2904


Miscellaneous


Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels – Isabel Kurth, Norihiro Yamaguchi, Celia Andreu-Agullo, Helen S. Tian, Subhasree Sridhar, Shugaku Takeda, Foster C. Gonsalves, Jia Min Loo, Afsar Barlas, Katia Manova-Todorova, Robert Busby, Johanna C. Bendell, James Strauss, Marwan Fakih, Autumn J. McRee, Andrew E. Hendifar, Lee S. Rosen, Andrea Cercek, Robert Wasserman, Michael Szarek, Scott L. Spector, Syed Raza, Masoud F. Tavazoie, Sohail F. Tavazoie. https://www.science.org/doi/full/10.1126/sciadv.abi7511

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy – Gang Wei, Honglin Sun, Kai Dong, Libing Hu, Qi Wang, Qian Zhuang, Yan Zhu, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang, Junli Liu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00375-2

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas – Nieves Calvo-Vidal, Nahuel Zamponi, Jan Krumsiek, Max A. Stockslager, Maria V. Revuelta, Jude M. Phillip, Rossella Marullo, Ekaterina Tikhonova, Nikita Kotlov, Jayeshkumar Patel, Shao Ning Yang, Lucy Yang, Tony Taldone, Catherine Thieblemont, John P. Leonard, Peter Martin, Giorgio Inghirami, Gabriela Chiosis, Scott R. Manalis and Leandro Cerchietti. https://cancerres.aacrjournals.org/content/81/20/5202


Reviews


Physiological impact of in vivo stable isotope tracing on cancer metabolism – Manuel Grima-Reyes, Adriana Martinez-Turtos, Ifat Abramovich, Eyal Gottlieb, Johanna Chiche, Jean-Ehrland Ricci. https://www.sciencedirect.com/science/article/pii/S2212877821001393

New roles for gluconeogenesis in vertebrates – Katharina Leithner. https://www.sciencedirect.com/science/article/pii/S2452310021000846

A map of the altered glioma metabolism – Ruhi Deshmukh, Maria Francesca Allega, Saverio Tardito. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00196-9

Redox Regulation in Cancer Cells during Metastasis – Alpaslan Tasdogan, Jessalyn M. Ubellacker, and Sean J. Morrison. https://cancerdiscovery.aacrjournals.org/content/11/11/2682

The role of lysosomal membrane proteins in glucose and lipid metabolism – Jing Gu, Mengya Geng, Mengxiang Qi, Lizhuo Wang, Yao Zhang, Jialin Gao. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202002602R

The Intersection of Purine and Mitochondrial Metabolism in Cancer – Humberto De Vitto, Danushka B. Arachchige, Brian C. Richardson and Jarrod B. French. https://www.mdpi.com/2073-4409/10/10/2603

Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward – Maria Rain Jennings, David Munn, John Blazeck. https://jitc.bmj.com/content/9/10/e003013

Pharmacological targeting of endoplasmic reticulum stress in disease – Stefan J. Marciniak, Joseph E. Chambers and David Ron. https://www.nature.com/articles/s41573-021-00320-3

Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors – Sayani Patra, Naveed Elahi, Aaron Armorer, Swathi Arunachalam, Joshua Omala, Iman Hamid, Anthony W Ashton, David Joyce, Xuanmao Jiao, Richard G Pestell.. https://www.frontiersin.org/articles/10.3389/fonc.2021.700629/full

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis – Shuo Yu, Simin Meng, Meixiang Xiang, Hong Ma. https://www.sciencedirect.com/science/article/pii/S2212877821001022


Comments


Nuclear PHGDH protects cancer cells from nutrient stress – Daniela Annibali and Sarah-Maria Fendt. https://www.nature.com/articles/s42255-021-00448-x

A leucine-derived fatty acid unlocks the mTOR to development – Chung-Yang Yeh, Dudley W. Lamming. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00735-8

Diet comparison suggests a lipid imbalance can slow tumour growth – Giulia Salvadori and Valter D. Longo. https://www.nature.com/articles/d41586-021-02775-1

MetaboList – September 2021


Mitochondria


Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress – Max-Hinderk Schuler, Alyssa M. English, Tianyao Xiao, Thane J. Campbell, Janet M. Shaw, Adam L. Hughes. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00688-2

NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation – Alexandros Papachristodoulou, Antonio Rodriguez-Calero, Sukanya Panja, Elizabeth Margolskee, Renu K. Virk, Teresa A. Milner, Luis Pina Martina, Jaime Y. Kim, Matteo Di Bernardo, Alanna B. Williams, Elvis A. Maliza, Joseph M. Caputo, Christopher Haas, Vinson Wang, Guarionex Joel De Castro, Sven Wenske, Hanina Hibshoosh, James M. McKiernan, Michael M. Shen, Mark A. Rubin, Antonina Mitrofanova, Aditya Dutta and Cory Abate-Shen. https://cancerdiscovery.aacrjournals.org/content/11/9/2316

Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER – David M. Booth, Péter Várnai, Suresh K. Joseph, György Hajnóczky. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00583-9?dgcid=raven_jbs_etoc_email

PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells – Gabriele Bluemel, Mélanie Planque Corina T. Madreiter-Sokolowskide, Theresa Haitzmann, Andelko Hrzenjakaf, Wolfgang F.Graierdg ,Sarah-Maria Fendt, Horst Olschewskiaf, Katharina Leithner. https://www.sciencedirect.com/science/article/pii/S0891584921007206

EVT-701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti-tumor activity in models of solid cancers – Raquel Luna Yolba, Virgile Visentin, Caroline Hervé  Johanna Chiche, Jean-Ehrland Ricci, Jérôme Méneyrol, Michaël R Paillasse, Nathalie Alet. https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.854

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes – Clair Crewe, Jan-Bernd Funcke, Shujuan Li, Nolwenn Joffin, Christy M. Gliniak, Alexandra L. Ghaben, Yu A. An, Hesham A. Sadek, Ruth Gordillo, Yucel Akgul, Shiuhwei Chen, Dmitri Samovski, Pamela Fischer-Posovszky, Christine M. Kusminski, Samuel Klein, Philipp E. Scherer. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00365-X


PDH / TCA


Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion – Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott and Pål Stenmark. https://www.nature.com/articles/s41467-021-25570-y

The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage – Sojeong Jun, Swetha Mahesula, Thomas P. Mathews, Misty S. Martin-Sandoval, Zhiyu Zhao, Elena Piskounova, Michalis Agathocleous. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00332-6

Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer – Ritesh K Aggarwal, Rebecca A Luchtel, Venkata Machha, Alexander Tischer, Yiyu Zou, Kith Pradhan, Nadia Ashai, Nandini Ramachandra, Joseph M Albanese, Jung-In Yang, Xiaoyang Wang, Srinivas Aluri, Shanisha Gordon, Ahmed Aboumohamed, Benjamin A Gartrell, Sassan Hafizi, James Pullman, Niraj Shenoy. https://www.pnas.org/content/118/39/e2106947118.long

Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis – Yihong Huan, Shuo Zheng, Ying Lin and Liming Ke. https://journals.asm.org/doi/abs/10.1128/MCB.00609-20


Glucose metabolism


Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program – Ke Tang, Liyan Zhu, Jie Chen, Dianheng Wang, Liping Zeng, Chen Chen, Liang Tang, Li Zhou, Keke Wei, Yabo Zhou, Jiadi Lv, Yuying Liu, Huafeng Zhang, Jingwei Ma and Bo Huang. https://cancerres.aacrjournals.org/content/81/19/4949

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia – Yusuke Saito, Mariko Kinoshita, Ai Yamada, Sayaka Kawano, Hong-Shan Liu, Sachiyo Kamimura, Midori Nakagawa, Syun Nagasawa, Tadao Taguchi, Shuhei Yamada, Hiroshi Moritake.. https://onlinelibrary.wiley.com/doi/10.1111/cas.15138

Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer – Kasey R. Cargill, C. Allison Stewart, Elizabeth M. Park, Kavya Ramkumar, Carl M. Gay, Robert J. Cardnell, Qi Wang, Lixia Diao, Li Shen, You-Hong Fan, Wai Kin Chan, Philip L. Lorenzi, Trudy G. Oliver, Jing Wang and Lauren A. Byers. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00270-9


Amino acid metabolism


Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells – Ibrahim H. Polat, Míriam Tarrado-Castellarnau, Adrian Benito, Claudia Hernandez-Carro, Josep Centelles, Silvia Marin and Marta Cascante. https://www.mdpi.com/2076-3921/10/9/1349

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2 – Angela Tramonti, Elisabet Cuyàs, José Antonio Encinar 5, Matthias Pietzke, Alessio Paone, Sara Verdura, Aina Arbusà  Begoña Martin-Castillo, Giorgio Giardina, Jorge Joven, Alexei Vazquez, Roberto Contestabile, Francesca Cutruzzolà, Javier A Menendez. https://www.mdpi.com/2072-6694/13/16/4009

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction – Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01153-0

MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis – Yuji Shiozaki, Shinobu Miyazaki-Anzai, Audrey L. Keenan and Makoto Miyazaki. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1968228


Lipid metabolism/citrate


NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions – Avi Kumar, Thekla Cordes, Anna E. Thalacker-Mercer, Ana M. Pajor, Anne N. Murphy, Christian M. Metallo. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01148-7

Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition – Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera and Johannes V. Swinnen. https://cancerres.aacrjournals.org/content/81/19/4981


Nucleotides


A hydride transfer complex reprograms NAD metabolism and bypasses senescence – Sebastian Igelmann, Frédéric Lessard, Oro Uchenunu, Jacob Bouchard, Ana Fernandez-Ruiz, Marie-Camille Rowell, Stéphane Lopes-Paciencia, David Papadopoli, Aurélien Fouillen, Katia Julissa Ponce, Geneviève Huot, Lian Mignacca, Mehdi Benfdil, Paloma Kalegari, Haytham M. Wahba, Jan Pencik, Nhung Vuong, Jordan Quenneville, Jordan Guillon, Véronique Bourdeau, Laura Hulea, Etienne Gagnon, Lukas Kenner, Richard Moriggl, Antonio Nanci, Michael N. Pollak, James G. Omichinski, Ivan Topisirovic, Gerardo Ferbeyre. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00695-X

MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer – Qiangsheng Hu, Yi Qin, Shunrong Ji, Xiuhui Shi, Weixing Dai, Guixiong Fan, Shuo Li, Wenyan Xu, Wensheng Liu, Mengqi Liu, Zheng Zhang, Zeng Ye, Zhijun Zhou, Jingxuan Yang, Qifeng Zhuo, Xianjun Yu, Min Li and Xiaowu Xu. https://cancerres.aacrjournals.org/content/81/19/4964


AMPK


Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK – Che-Chia Hsu, Xian Zhang, Guihua Wang, Weina Zhang, Zhen Cai, Bo-Syong Pan, Haiwei Gu, Chuan Xu, Guoxiang Jin, Xiangshang Xu, Rajesh Kumar Manne, Yan Jin, Wei Yan, Jingwei Shao, Tingjin Chen, Emily Lin, Amit Ketkar, Robert Eoff, Zhi-Gang Xu, Zhong-Zhu Chen, Hong-Yu Li, Hui-Kuan Lin. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00692-4

AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism – Flavio R. Palma, Bianca A. Ratti, Veronica Paviani, Diego R. Coelho, Rodrigo Miguel, Jeanne M. Danes, Sofia V. Zaichik, Andre L. de Abreu, Sueli O. Silva, Yiliang Chen, Roy L. Silverstein, Uppal Karan, Dean P. Jones and Marcelo G. Bonini. https://www.nature.com/articles/s41388-021-01943-x

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy – Joshua C. Drake, Rebecca J. Wilson, Rhianna C. Laker, Yuntian Guan, Hannah R. Spaulding, Anna S. Nichenko, Wenqing Shen, Huayu Shang, Maya V. Dorn, Kian Huang, Mei Zhang, Aloka B. Bandara, Matthew H. Brisendine, Jennifer A. Kashatus, Poonam R. Sharma, Alexander Young, Jitendra Gautam, Ruofan Cao, Horst Wallrabe, Paul A. Chang, Michael Wong, Eric M. Desjardins, Simon A. Hawley, George J. Christ, David F. Kashatus, Clint L. Miller, Matthew J. Wolf, Ammasi Periasamy, Gregory R. Steinberg, D. Grahame Hardie, and Zhen Yan. https://www.pnas.org/content/118/37/e2025932118.abstract?etoc

Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function – Xiang Xu, Guangjin Ding, Caizhi Liu, Yuhan Ding, Xiaoxin Chen, Xiaoli Huang, Chen-Song Zhang, Shanxin Lu, Yunpeng Zhang, Yuanyong Huang, Zhaosu Chen, Wei Wei, Lujian Liao, Shu-Hai Lin, Jingya Li, Wei Liu, Jiwen Li, Sheng-Cai Lin, Xinran Ma, Jiemin Wong. https://doi.org/10.1038/s41422-021-00565-y


mTOR


Dissecting the biology of mTORC1 beyond rapamycin – Guang Yang, Deanne Francis, James R. Krycer, Mark Larance, Ziyang Zhang, Chris J. Novotny, Alexis Diaz-Vegas, Kevan M. Shokat, David E. James. https://www.science.org/doi/abs/10.1126/scisignal.abe0161

Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells – Sung Eun Kim, Justin Zhang, Enoch Jiang, Michael Overholtzer. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100870R


IDH


Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells – Dong Chen, Siyuan Xia, Rukang Zhang, Yuancheng Li, Christopher A. Famulare, Hao Fan, Rong Wu, Mei Wang, Allen C. Zhu, Shannon E. Elf, Rui Su, Lei Dong, Martha Arellano, William G. Blum, Hui Mao, Sagar Lonial, Wendy Stock, Olatoyosi Odenike, Michelle Le Beau, Titus J. Boggon, Chuan He, Jianjun Chen, Xue Gao, Ross L. Levine, Jing Chen. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00507-4

Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis – Xun Liu, Kiyoshi Yamaguchi, Kiyoko Takane, Chi Zhu, Makoto Hirata, Yoko Hikiba, Shin Maeda, Yoichi Furukawa, Tsuneo Ikenoue. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257090

Wild-type IDH2 protects nuclear DNA from oxidative damage and is a potential therapeutic target in colorectal cancer – Shuang Qiao, Wenhua Lu, Christophe Glorieux, Jiangjiang Li, Peiting Zeng, Ning Meng, Huiqin Zhang, Shijun Wen and Peng Huang. https://www.nature.com/articles/s41388-021-01968-2

Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL – Liat Goldberg, Vijay Negi, Yang Jo Chung, Masahiro Onozawa, Yuelin J. Zhu, Robert L. Walker, Rachel Pierce, Daxesh P. Patel, Kristopher W. Krausz, Frank J. Gonzalez, Margaret A. Goodell, Benjamin A.T. Rodriguez, Paul S. Meltzer and Peter D. Aplan. https://cancerres.aacrjournals.org/content/81/19/5033

G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy – Mahmoud S. Alghamri, Brandon L. McClellan, Ruthvik P. Avvari, Rohit Thalla, Stephen Carney, Margaret S. Hartlage, Santiago Haase, Maria Ventosa, Ayman Taher, Neha Kamran, Li Zhang, Syed Mohd Faisal, Felipe J. Núñez, María Belén Garcia-Fabiani, Wajd N. Al-Holou, Daniel Orringer, Shawn Hervey-Jumper, Jason Heth, Parag G. Patil, Karen Eddy, Sofia D. Merajver, Peter J. Ulintz, Joshua Welch, Chao Gao, Jialin Liu, Gabriel Núñez, Dolores Hambardzumyan, Pedro R. Lowenstein, Maria G. Castro. https://www.science.org/doi/full/10.1126/sciadv.abh3243


Cancer Immunometabolism


G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy – Mahmoud S. Alghamri, Brandon L. McClellan, Ruthvik P. Avvari, Rohit Thalla, Stephen Carney, Margaret S. Hartlage, Santiago Haase, Maria Ventosa, Ayman Taher, Neha Kamran, Li Zhang, Syed Mohd Faisal, Felipe J. Núñez, María Belén Garcia-Fabiani, Wajd N. Al-Holou, Daniel Orringer, Shawn Hervey-Jumper, Jason Heth, Parag G. Patil, Karen Eddy, Sofia D. Merajver, Peter J. Ulintz, Joshua Welch, Chao Gao, Jialin Liu, Gabriel Núñez, Dolores Hambardzumyan, Pedro R. Lowenstein, Maria G. Castro. https://www.science.org/doi/full/10.1126/sciadv.abh3243

SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation – Guillaume Bidault, Samuel Virtue, Kasparas Petkevicius, Helen E. Jolin, Aurélien Dugourd, Anne-Claire Guénantin, Jennifer Leggat, Betania Mahler-Araujo, Brian Y. H. Lam, Marcella K. Ma, Martin Dale, Stefania Carobbio, Arthur Kaser, Padraic G. Fallon, Julio Saez-Rodriguez, Andrew N. J. McKenzie and Antonio Vidal-Puig. https://www.nature.com/articles/s42255-021-00440-5


Miscellaneous


Brief report: The uricase mutation in humans increases our risk for cancer growth – Mehdi A. Fini, Miguel A. Lanaspa, Eric A. Gaucher, Brian Boutwell, Takahiko Nakagawa, Richard M. Wright, Laura G. Sanchez-Lozada, Peter Andrews, Kurt R. Stenmark and Richard J. Johnson. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00268-3

RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease – Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J. McCann, Talya S. Laufer, Nicolas Gordon, Irina A. Vasilevskaya, Emanuela Dylgjeri, Saswati N. Chand, Matthew J. Schiewer, Josep Domingo-Domenech, Robert B. Den, Jeff Holst, Peter A. McCue, Johann S. de Bono, Christopher McNair and Karen E. Knudsen. https://cancerdiscovery.aacrjournals.org/content/11/9/2334

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth – Rojyar Khezri, Petter Holland, Todd Andrew Schoborg, Ifat Abramovich, Szabolcs Takáts, Caroline Dillard, Ashish Jain, Fergal O’Farrell, Sebastian Wolfgang Schultz, William M Hagopian, Eduardo Martin Quintana, Rachel Ng, Nadja Sandra Katheder, Mohammed Mahidur Rahman, José Gerardo Teles Reis, Andreas Brech, Heinrich Jasper, Nasser M Rusan, Anne Hope Jahren, Eyal Gottlieb, Tor Erik Rusten. https://www.embopress.org/doi/full/10.15252/embj.2020107336

Stable isotope tracing to assess tumor metabolism in vivo – Brandon Faubert, Alpaslan Tasdogan, Sean J. Morrison, Thomas P. Mathews and Ralph J. DeBerardinis. https://www.nature.com/articles/s41596-021-00605-2


Reviews


SnapShot: Cancer metabolism – Julia S. Brunner, Lydia W.S. Finley. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00501-3

Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet – Steven Zhao, Ronal M. Peralta; Natalia Avina-Ochoa, Greg M. Delgoffe, Susan M.Kaech. https://www.sciencedirect.com/science/article/abs/pii/S1044532321000166?

AMPK: restoring metabolic homeostasis over space and time – Elijah Trefts, Reuben J. Shaw. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00682-1

Redox metabolism: ROS as specific molecular regulators of cell signaling and function – Claudia Lennicke, Helena M. Cochemé. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00685-7

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity – Haejin Yoon, Jillian L. Shaw, Marcia C. Haigis, Anna Greka. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00694-8

Supply and demand: Cellular nutrient uptake and exchange in cancer – Vasileios Papalazarou, Oliver D.K. Maddocks. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00693-6

The context-specific roles of urea cycle enzymes in tumorigenesis – Emma Hajaj, Marco Sciacovelli, Christian Frezza, Ayelet Erez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00645-6

Moonlighting functions of metabolic enzymes and metabolites in cancer – Chaoyun Pan, Bo Li, M. Celeste Simon. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00698-5

Metabolic channeling: predictions, deductions, and evidence – Vidhi Pareek, Zhou Sha, Jingxuan He, Ned S. Wingreen, Stephen J. Benkovic. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00697-3

The multifaceted regulation of mitophagy by endogenous metabolites – Ting Zhang, Qian Liu, Weihua Gao, Sheikh Arslan Sehgal and Hao Wu. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1975914

The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance – Kangchen Chen, Chenzhi Zhang, Sunbin Ling, Rongli Wei, Jianguo Wang and Xiao Xu. https://www.nature.com/articles/s41419-021-04116-6


Comments


Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect – Aaron M. Hosios, and Brendan D. Manning. https://cancerres.aacrjournals.org/content/81/19/4896

More Metabolism! – James A. Olzmann, Sarah-Maria Fendt, Yatrik Shah, Karen Vousden, Navdeep Chandel, Tiffany Horng, Nika Danial, Benjamin Tu, Heather Christofk, Matthew G. Vander Heiden, Kathryn Wellen. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00712-7

Mitochondrial-derived compartments: A “fusel alcohol generator” in yeast? – Tim König, Heidi M. McBride. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00712-7

A novel redox cycle diverts cells from oncogene-induced senescence into cancer – Mate Maus, Manuel Serrano. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00690-0

Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon? – Laura A. Sena, and Samuel R. Denmeade. https://cancerres.aacrjournals.org/content/81/17/4385

T cells critically depend on pyruvate oxidation – Christopher Schrecker, Andrew M. Intlekofer. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00373-9


Online registrations available: EMBO workshop on Cancer Immunometabolism

https://meetings.embo.org/event/21-cancer