MetaboList – June 2020


Serine / glycine / one carbon


Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcomaMadi Y. Cissé , Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, Hélène Delpech, Romain Riscal, Giuseppe Arena, Frédéric Chibon, Sophie Le Gellec, Aurélie Maran-Gonzalez, Marie-Christine Chateau, Charles Theillet, Sébastien Carrere, Jean-Charles Portais, Laurent Le Cam, Laetitia K. Linares. https://stm.sciencemag.org/content/12/547/eaay2163.full

SHMT Inhibition Is Effective and Synergizes With Methotrexate in T-cell Acute Lymphoblastic LeukemiaJuan C García-Cañaveras, Olga Lancho, Gregory S Ducker, Jonathan M Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D Rabinowitz. https://pubmed.ncbi.nlm.nih.gov/32382081

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencingSara Parsa, Ana Ortega-Molina, Hsia-Yuan Ying, Man Jiang, Matt Teater, Jiahui Wang, Chunying Zhao, Ed Reznik, Joyce P. Pasion, David Kuo, Prathibha Mohan, Shenqiu Wang, Jeannie M. Camarillo, Paul M. Thomas, Neeraj Jain, Javier Garcia-Bermudez, Byoung-kyu Cho, Wayne Tam, Neil L. Kelleher, Nicholas Socci, Ahmet Dogan, Elisa De Stanchina, Giovanni Ciriello, Michael R. Green, Sheng Li, Kivanc Birsoy, Ari M. Melnick and Hans-Guido Wendel. https://www.nature.com/articles/s43018-020-0080-0

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progressionJuan Liu, Cen Zhang, Hao Wu, Xiao-Xin Sun, Yanchen Li, Shan Huang, Xuetian Yue, Shou-En Lu, Zhiyuan Shen, Xiaoyang Su, Eileen White, Bruce G. Haffty, Wenwei Hu, and Zhaohui Feng. https://www.jci.org/articles/view/132876


Other amino acids


Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic CancerSeth J. Parker, Caroline R. Amendola, Kate E.R. Hollinshead, Qijia Yu, Keisuke Yamamoto, Joel Encarnación-Rosado, Rebecca E. Rose, Madeleine M. LaRue, Albert S.W. Sohn, Doug E. Biancur, Joao A. Paulo, Steven P. Gygi, Drew R. Jones, Huamin Wang, Mark R. Philips, Dafna Bar-Sagi, Joseph D. Mancias and Alec C. Kimmelman. https://cancerdiscovery.aacrjournals.org/content/10/7/1018

Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cellsAimin Cai, Hailun Zheng, Zhiwei Chen, Xinlu Lin, Chen Li, Qing yao, Yangzom D. Bhutia, Vadivel Ganapathy, Ruijie Chen, Longfa Kou. https://portlandpress.com/biochemj/article/477/10/1923/223853

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrenceChao-Chieh Lin, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, Jeremy Force, Jeffrey R. Marks, Tso-Pang Yao, James V. Alvarez and Jen-Tsan Chi. https://www.nature.com/articles/s41418-020-0499-y


Glucose metabolism


Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast CancerLisa M. Becker, Joyce T. O’Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu, Raghu Kalluri. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30671-9

PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancerDanna Yeerken, Ruoxi Hong, Yan Wang, Ying Gong, Rui Liu, Di Yang, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang, Qimin Zhan. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233750

Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor MicroenvironmentPei-pei Hou, Li-juan Luo, Hang-zi Chen, Qi-tao Chen, Xue-li Bian, Sheng-fu Wu, Jia-xin Zhou, Wen-xiu Zhao, Jian-ming Liu, Xiao-min Wang, Zhi-yuan Zhang, Lu-ming Yao, Qinghua Chen, Dawang Zhou, Qiao Wu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30305-1

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblastsAkiko Kogure, Yutaka Naito, Yusuke Yamamoto, Masakazu Yashiro, Tohru Kiyono, Kazuyoshi Yanagihara, Kosei Hirakawa, Takahiro Ochiya. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234613

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen and Ning Zhang. https://www.nature.com/articles/s41467-020-16966-3

Label-free sensing of exosomal MCT1 and CD147  for tracking metabolic reprogramming and  malignant progression in gliomaA. Thakur , G. Qiu, C. Xu, X. Han, T. Yang, S. P. NG, K. W. Y. Chan, C. M. L. Wu, Y. Lee. https://advances.sciencemag.org/content/6/26/eaaz6119


Lipid metabolism


REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumorsShuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke,  Krushna Chandra Patra, Elma Zaganjor, Kenneth Ross, Yusuke Mizukami,  Sarah Jeanfavre, Athena Chen, Mari Mino-Kenudson, Sridhar Ramaswamy,  Clary Clish, Marcia Haigis, Nabeel Bardeesy and Leif W. Ellisen. http://genesdev.cshlp.org/content/34/11-12/751.abstract?etoc

PHGDH supports liver ceramide synthesis and sustains lipid homeostasisYun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth and Gina M. DeNicola. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00212-x

Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolismErol C. Bayraktar, Konnor La, Kara Karpman, Gokhan Unlu, Ceren Ozerdem, Dylan J. Ritter, Hanan Alwaseem, Henrik Molina, Hans-Heinrich Hoffmann, Alec Millner, G. Ekin Atilla-Gokcumen, Eric R. Gamazon, Amy R. Rushing, Ela W. Knapik, Sumanta Basu and Kıvanç Birsoy. https://www.nature.com/articles/s42255-020-0206-9

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolismMichael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone and Jason Moffat. https://www.nature.com/articles/s42255-020-0211-z

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancerKaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson and Martin C. Sadowski. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00217-6

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived EicosanoidsNikos Koundouros, Evdoxia Karali, Aurelien Tripp, Adamo Valle, Paolo Inglese, Nicholas J.S. Perry, David J. Magee, Sara Anjomani Virmouni, George A. Elder, Adam L. Tyson, Maria Luisa Dória, Antoinette van Weverwijk, Renata F. Soares, Clare M. Isacke, Jeremy K. Nicholson, Robert C. Glen, Zoltan Takats, George Poulogiannis. https://www.cell.com/cell/fulltext/S0092-8674(20)30686-3


Nucleotides


ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine SynthesisEunus S. Ali, Umakant Sahu, Elodie Villa, Brendan P. O’Hara, Peng Gao, Cynthia Beaudet, Antony W. Wood, John M. Asara, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30302-6

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxiaKarolina Losenkova, Mariachiara Zuccarini, Marika Karikoski, Juha Laurila, Detlev Boison, Sirpa Jalkanen and Gennady G. Yegutkin. http://jcs.biologists.org/content/133/10/jcs241463?etoc


Mitochondria


Defective NADPH production in mitochondrial disease complex I causes inflammation and cell deathEduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench and Pere Puigserver. https://www.nature.com/articles/s41467-020-16423-1

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growthŽiva Frangež, Yuniel Fernández-Marrero, Darko Stojkov, S. Morteza Seyed Jafari, Robert E. Hunger, Valentin Djonov, Carsten Riether and Hans-Uwe Simon. https://www.nature.com/articles/s41388-020-1339-8

Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal TumorHuang WK, Gao J, Chen Z, Shi H, Yuan J, Cui HL, Yeh CN, Bränström R, Larsson C, Li S, Lui WO. https://www.mdpi.com/2073-4409/9/6/1333

ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK InhibitionWeinan Guo, Jinyuan Ma, Yuqi Yang, Sen Guo, Weigang Zhang, Tao Zhao, Xiuli Yi, Huina Wang, Shiyu Wang, Yu Liu, Wei Dai, Xuguang Chen, Qiong Shi, Gang Wang, Tianwen Gao and Chunying Li. https://clincancerres.aacrjournals.org/content/26/11/2725


Nutrient sensing / starvation


H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell DeathYilei Zhang, Jiejun Shi, Xiaoguang Liu, Zhenna Xiao, Guang Lei, Hyemin Lee, Pranavi Koppula, Weijie Cheng, Chao Mao, Li Zhuang, Li Ma, Wei Li and Boyi Gan. https://cancerres.aacrjournals.org/content/80/11/2243

Leucine regulates autophagy via acetylation of the mTORC1 component raptorSung Min Son, So Jung Park, Eleanna Stamatakou, Mariella Vicinanza, Fiona M. Menzies and David C. Rubinsztein. https://www.nature.com/articles/s41467-020-16886-2

Metabolic energy sensing by mammalian CLC anion/proton exchangersMatthias Grieschat, Raul E Guzman, Katharina Langschwager, Christoph Fahlke, Alexi K Alekov. https://www.embopress.org/doi/full/10.15252/embr.201947872?campaign=woletoc

The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERKQin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15144?campaign=woletoc

Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylationCarlo Yague-Sanz, Yann Vanrobaeys, Ronan Fernandez, Maxime Duval, Marc Larochelle, Jude Beaudoin, Julien Berro, Simon Labbé, Pierre-Étienne Jacques and François Bachand. http://genesdev.cshlp.org/content/34/13-14/883.abstract?etoc


mTOR / AMPK


Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitorsChase H. Melick, Jenna L. Jewell. https://portlandpress.com/biochemj/article/477/10/1847/222875

Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic MutationsPatrick Hansmann, Anne Brückner, Stephan Kiontke, Bianca Berkenfeld, Guiscard Seebohm, Pascal Brouillard, Miikka Vikkula, Floor E. Jansen, Mark Nellist, Andrea Oeckinghaus, Daniel Kümmel. https://www.cell.com/structure/fulltext/S0969-2126(20)30177-5

FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restrictionAvantika Gupta, Hugo Stocker. https://elifesciences.org/articles/53159

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancerArcadi Cipponi, David L. Goode, Justin Bedo, Mark J. McCabe, Marina Pajic, David R. Croucher, Alvaro Gonzalez Rajal, Simon R. Junankar, Darren N. Saunders, Pavel Lobachevsky, Anthony T. Papenfuss, Danielle Nessem, Max Nobis, Sean C. Warren, Paul Timpson, Mark Cowley, Ana C. Vargas, Min R. Qiu, Daniele G. Generali, Shivakumar Keerthikumar, Uyen Nguyen, Niall M. Corcoran, Georgina V. Long, Jean-Yves Blay, David M. Thomas. https://science.sciencemag.org/content/368/6495/1127

AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1Eri Matsumoto, Kaho Akiyama, Takuya Saito, Yu Matsumoto, Ken-Ichi Kobayashi, Jun Inoue, Yuji Yamamoto, Tsukasa Suzuki. https://portlandpress.com/biochemj/article/477/12/2237/225005


Diet and cancer


Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trialStefanie de Groot, Rieneke T. Lugtenberg, Danielle Cohen, Marij J. P. Welters, Ilina Ehsan, Maaike P. G. Vreeswijk, Vincent T. H. B. M. Smit, Hiltje de Graaf, Joan B. Heijns, Johanneke E. A. Portielje, Agnes J. van de Wouw, Alex L. T. Imholz, Lonneke W. Kessels, Suzan Vrijaldenhoven, Arnold Baars, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Valter D. Longo, Hanno Pijl, Judith R. Kroep & Dutch Breast Cancer Research Group (BOOG). https://www.nature.com/articles/s41467-020-16138-3

Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor MacrophagesLianliang Liu, Rong Jin, Jiaqing Hao, Jun Zeng, Di Yin, Yanmei Yi, Mingming Zhu, Anita Mandal, Yuan Hua, Chin K. Ng, Nejat K. Egilmez, Edward R. Sauter and Bing Li. https://cancerres.aacrjournals.org/content/80/12/2564

A Randomized Controlled Trial of a 6-Month Low-Carbohydrate Intervention on Disease Progression in Men with Recurrent Prostate Cancer: Carbohydrate and Prostate Study 2 (CAPS2)Stephen J. Freedland, Jenifer Allen, Aubrey Jarman, Taofik Oyekunle, Andrew J. Armstrong, Judd W. Moul, Howard M. Sandler, Edwin Posadas, Dana Levin, Emily Wiggins, Lauren E. Howard, Yuan Wu and Pao-Hwa Lin. https://clincancerres.aacrjournals.org/content/26/12/3035


Biguanides / Antifolates


GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-PhosphateJianjiang Xie, Jianheng Ye, Zhiduan Cai, Yong Luo, Xuejin Zhu, Yulin Deng, Yuanfa Feng, Yingke Liang, Ren Liu, Zhaodong Han, Yuxiang Liang, Yu Zheng, Rujun Mo, Yangjia Zhuo, Yongding Wu, Funeng Jiang, Jianguo Zhu, Chin-Lee Wu and Weide Zhong. https://cancerres.aacrjournals.org/content/80/11/2150 

Repression of LKB1 by miR-1792 Sensitizes MYC-Dependent Lymphoma to Biguanide TreatmentIzreig S, Gariepy A, Kaymak I, Bridges HR, Donayo AO, Bridon G, DeCamp LM, Kitchen-Goosen SM, Avizonis D, Sheldon RD, Laister RC, Minden MD, Johnson NA, Duchaine TF, Rudoltz MS, Yoo S, Pollak MN, Williams KS, Jones RG. https://pubmed.ncbi.nlm.nih.gov/32478334/

Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma–Derived CellsYasuo Takashima, Azusa Hayano and Ryuya Yamanaka. https://clincancerres.aacrjournals.org/content/26/11/2754


Methods


Using arterial–venous analysis to characterize cancer metabolic consumption in patientsNanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G. Zacharias, Hong Lin, Hieu S. Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J. DeBerardinis, Hao Xu and Woo-ping Ge. https://www.nature.com/articles/s41467-020-16810-8

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal AdenocarcinomaKazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Shun Kishimoto, Nobu Oshima, Rajani Choudhuri, Stephen S. Adler, Elaine M. Jagoda, Keita Saito, Nallathamby Devasahayam, Peter L. Choyke, James B. Mitchell and Murali C. Krishna. https://cancerres.aacrjournals.org/content/80/11/2087

Comparative assessment of purified saponins as permeabilization agents during respirometryCorinna Dawid, Daniela Weber, Eva Musiol, Vanessa Janas, Sebastian Baur, Roman Lang, Tobias Fromme. https://www.sciencedirect.com/science/article/abs/pii/S0005272820301018


Cancer Immunometabolism


Inosine is an alternative carbon source for CD8+-T-cell function under glucose restrictionTingting Wang, J. N. Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Hayley Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Penghui Lin, Zayda Lizbeth Piedra-Quintero, Mireia Guerau-de-Arellano, Kevin A. Cassady, Song Guo Zheng, Jun Yang, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan and Ruoning Wang. https://www.nature.com/articles/s42255-020-0219-4


Miscellaneous


T cells with dysfunctional mitochondria induce multimorbidity and premature senescenceGabriela Desdín-Micó, Gonzalo Soto-Heredero, Juan Francisco Aranda, Jorge Oller, Elisa Carrasco, Enrique Gabandé-Rodríguez, Eva Maria Blanco, Arantzazu Alfranca, Lorena Cussó, Manuel Desco, Borja Ibañez, Arancha R. Gortazar, Pablo Fernández-Marcos, Maria N. Navarro, Bruno Hernaez, Antonio Alcamí, Francesc Baixauli, María Mittelbrunn. https://science.sciencemag.org/content/368/6497/1371

Intracellular pH controls WNT downstream of glycolysis in amniote embryosMasayuki Oginuma, Yukiko Harima, Oscar A. Tarazona, Margarete Diaz-Cuadros, Arthur Michaut, Tohru Ishitani, Fengzhu Xiong and Olivier Pourquié. https://www.nature.com/articles/s41586-020-2428-0

Oncometabolites suppress DNA repair by disrupting local chromatin signallingParker L. Sulkowski, Sebastian Oeck, Jonathan Dow, Nicholas G. Economos, Lily Mirfakhraie, Yanfeng Liu, Katelyn Noronha, Xun Bao, Jing Li, Brian M. Shuch, Megan C. King, Ranjit S. Bindra and Peter M. Glazer. https://www.nature.com/articles/s41586-020-2363-0

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1Rodrigo Romero, Francisco J. Sánchez-Rivera, Peter M. K. Westcott, Kim L. Mercer, Arjun Bhutkar, Alexander Muir, Tania J. González Robles, Swanny Lamboy Rodríguez, Laura Z. Liao, Sheng Rong Ng, Leanne Li, Caterina I. Colón, Santiago Naranjo, Mary Clare Beytagh, Caroline A. Lewis, Peggy P. Hsu, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks. https://www.nature.com/articles/s43018-020-0071-1

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolismHo JJD, Balukoff NC, Theodoridis PR, Wang M, Krieger JR, Schatz JH, Lee S. https://pubmed.ncbi.nlm.nih.gov/32472050/


Reviews


The Molecular Link from Diet to Cancer Cell MetabolismShree Bose, Annamarie E. Allen, Jason W. Locasale. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30319-1

Dietary Approaches to Cancer TherapyMylène Tajan, Karen H. Vousden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30204-X

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer ImmunotherapyJackie E. Bader, Kelsey Voss, Jeffrey C. Rathmell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30355-5

Drilling for Oil: Tumor-Surrounding Adipocytes Fueling CancerCamille Attané, Catherine Muller. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30084-4

Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolismBouthelier A, Aragonés J. https://www.sciencedirect.com/science/article/abs/pii/S0167488920300914

Systemic effects of mitochondrial stressRaz BarZiv, Theodore Bolas, Andrew Dillin. https://www.embopress.org/doi/abs/10.15252/embr.202050094?campaign=woletoc

You are what you eat – How nutrition and metabolism shape the genome through epigeneticsTill Bartke, Robert Schneider. https://www.sciencedirect.com/science/article/pii/S2212877820300612

Compartmentalised acyl-CoA metabolism and roles in chromatin regulationSophie Trefely, Claudia D. Lovell, Nathaniel W. Snyder, Kathryn E. Wellen. https://www.sciencedirect.com/science/article/pii/S2212877820300077

The taming of PARP1 and its impact on NAD+ metabolismSarah Hurtado-Bagès, Gunnar Knobloch, Andreas G. Ladurner, Marcus Buschbeck. https://www.sciencedirect.com/science/article/pii/S2212877820300223

Metabolic Escape Routes of Cancer Stem Cells and Therapeutic OpportunitiesTurdo A, Porcelli G, D’Accardo C, Franco SD, Verona F, Forte S, Giuffrida D, Memeo L, Todaro M, Stassi G. https://www.mdpi.com/2072-6694/12/6/1436

Role of amino acids in regulation of ROS balance in cancerJaune-Pons E, Vasseur S. https://www.sciencedirect.com/science/article/abs/pii/S0003986120304471?via%3Dihub

Chromatin-remodeling links metabolic signaling to gene expressionAshby J.Morrison. https://www.sciencedirect.com/science/article/pii/S2212877820300466

Metabolic Regulation of Tissue Stem CellsSuzanne N. Shapira, Heather R. Christofk. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30075-1

Cytokine-like Roles for Metabolites in ImmunityZbigniew Zasłona, Luke A.J. O’Neill. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30228-8 


Comments


Extracellular serine feeds cancer skin stem cellsKim Baumann. https://www.nature.com/articles/s41580-020-0261-9

Tumour metabolites hinder DNA repairLei-Lei Chen, Yue Xiong. https://www.nature.com/articles/d41586-020-01569-1

Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancerW. Brian Dalton. https://www.jci.org/articles/view/137411

Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer – https://cancerdiscovery.aacrjournals.org/content/10/6/757.1

MetaboList – May 2020


Glucose metabolism


A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway – Jonathan M. Ghergurovich, Juan C. García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, Mari Carmen Gomez-Cabrera, Agustín Lahoz, Jing Fan, Ulf H. Beier, Hahn Kim and Joshua D. Rabinowitz. https://www.nature.com/articles/s41589-020-0533-x

N6-methyladenosine regulates glycolysis of cancer cells through PDK4 – Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin and Hongsheng Wang. https://www.nature.com/articles/s41467-020-16306-5

Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts – Kozlov AM, Lone A, Betts DH, Cumming RC. https://www.nature.com/articles/s41598-020-65193-9

Glycolytic biomarkers predict transformation in patients with follicular lymphoma – Ida Monrad, Charlotte Madsen, Kristina Lystlund Lauridsen, Bent Honoré, Trine Lindhardt Plesner, Stephen Hamilton-Dutoit, Francesco d’Amore, Maja Ludvigsen. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233449


Methionine, Serine, one-carbon


Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function – Henry Kurniawan, Davide G. Franchina, Luana Guerra, Lynn Bonetti, Leticia Soriano – Baguet, Melanie Grusdat, Lisa Schlicker, Oliver Hunewald, Catherine Dostert, Myriam P. Merz, Carole Binsfeld, Gordon S. Duncan, Sophie Farinelle, Yannic Nonnenmacher, Jillian Haight, Dennis Das Gupta, Anouk Ewen, Rabia Taskesen, Rashi Halder, Ying Chen, Christian Jäger, Markus Ollert, Paul Wilmes, Vasilis Vasiliou, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Jonathan D. Turner, Tak W. Mak, Michael Lohoff, Johannes Meiser, Karsten Hiller, Dirk Brenner. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30119-4

DISTINCT PATTERN OF ONE-CARBON METABOLISM, A NUTRIENT-SENSITIVE PATHWAY, IN INVASIVE BREAST CANCER: A METABOLOMIC STUDYJéssica Reis Santos, Dan Linetzky Waitzberg, Ismael Dale Cotrim Guerreiro da Silva, Tharcisio Citrangulo Tortelli Junior, Luciana Rodrigues Carvalho Barros, Gisele André Baptista Canuto, Andréa Tedesco Faccio, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Marina Franco Maggi Tavares, Ana Cristina Martinez, Ângela Flavia Logullo, Raquel Suzana M.M. Torrinhas, and Graziela Ravacci. https://www.oncotarget.com/article/27575/text/

Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity – Nairita Maitra, Chong He, Heidi M Blank, Mitsuhiro Tsuchiya, Birgit Schilling,  Matt Kaeberlein, Rodolfo Aramayo, Brian K Kennedy , Michael Polymenis. https://elifesciences.org/articles/53127 


Other amino acids / polyamines


Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress – Simon Schwörer, Mirela Berisa, Sara Violante, Weige Qin, Jiajun Zhu, Ronald C Hendrickson, Justin R Cross, Craig B Thompson. https://www.embopress.org/doi/abs/10.15252/embj.2019103334

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma – Tjaden B, Baum K, Marquardt V, Simon M, Trajkovic-Arsic M, Kouril T, Siebers B, Lisec J, Siveke JT, Schulte JH, Benary U, Remke M, Wolf J, Schramm A. https://www.nature.com/articles/s41598-020-64040-1

Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs – Akihiko Sakamoto, Yusuke Terui, Takeshi Uemura, Kazuei Igarashi and Keiko Kashiwagi. http://www.jbc.org/content/early/2020/05/06/jbc.RA120.013833.abstract

Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling – Shailer B. Martin, William S. Reiche, Nicholas A. Fifelski, Alexander J. Schultz, Spencer J. Stanford, Alexander A. Martin, Danielle L. Nack, Bernhard Radlwimmer, Michael P. Boyer, Elitsa A. Ananieva. https://portlandpress.com/biochemj/article/477/9/1579/222659/Leucine-and-branchedchain-amino-acid-metabolism

Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum – Cassandra E. Holbert, Matthew Dunworth, Jackson R. Foley, Tiffany T. Dunston, Tracy Murray Stewart and Robert A. Casero Jr. http://www.jbc.org/content/early/2020/05/19/jbc.RA120.013867.abstract


Nucleotides


Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex – Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A. https://www.jbc.org/content/early/2020/05/21/jbc.RA119.012175

SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network – Archan Chakraborty, Wei-Cheng Lin, Yu-Tsun Lin, Kuang-Jing Huang, Pei-Yu Wang, Ian Yi-Feng Chang, Hsiang-Iu Wang, Kung-Ting Ma, Chun-Yen Wang, Xuan-Rong Huang, Yen-Hsien Lee, Bi-Chang Chen, Ya-Ju Hsieh, Kun-Yi Chien, Tzu-Yang Lin, Ji-Long Liu, Li-Ying Sung, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai. https://jcs.biologists.org/content/133/9/jcs240200?etoc

Methotrexate Elicits Pro-Respiratory and Anti-Growth Effects by Promoting AMPK Signaling – David J Papadopoli, Eric H Ma, Dominic Roy, Mariana Russo, Gaëlle Bridon, Daina Avizonis, Russell G Jones, Julie St-Pierre. https://www.nature.com/articles/s41598-020-64460-z


Mitochondria


Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitorsÁlvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals. https://www.embopress.org/doi/full/10.15252/emmm.201911217

Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer – Jason R Brown, Daniel K. Chan, Jessica J Shank, Kent A. Griffith, Huihui Fan, Robert Szulawski, Kun Yang, R. Kevin Reynolds, Carolyn Johnston, Karen McLean, Shitanshu Uppal, J. Rebecca Liu, Lourdes Cabrera, Sarah E Taylor, Brian C. Orr, Francesmary Modugno, Pooja Mehta, Michael Bregenzer, Geeta Mehta, Hui Shen, Lan Coffman, and Ronald J. Buckanovich. https://insight.jci.org/articles/view/133247

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I – Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst,  Barrie Kellam, Anne E Willis. https://elifesciences.org/articles/55845

Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells – Kenta Kuramoto, Masahiro Yamamoto, Shuhei Suzuki, Tomomi Sanomachi, Keita Togashi, Shizuka Seino, Chifumi Kitanaka, Masashi Okada. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15187


Starvation / metabolic stress


Distinct Mitochondrial Defects Trigger the Integrated Stress Response Depending on the Metabolic State of the Cell – Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha. https://elifesciences.org/articles/49178

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy – David Pla‐Martín, Désirée Schatton, Janica L Wiederstein, Marie‐Charlotte Marx, Salim Khiati, Marcus Krüger, Elena I Rugarli. https://www.embopress.org/doi/full/10.15252/embj.2019102731

AKT Ser/Thr kinase increases V-ATPase–dependent lysosomal acidification in response to amino acid starvation in mammalian cells – Michael P. Collins, Laura A. Stransky and Michael Forgac. http://www.jbc.org/content/early/2020/05/14/jbc.RA120.013223.abstract


Nutrient sensing / ATF4


p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators – Charles N. Birts , Arindam Banerjee, Matthew Darley, Charles R. Dunlop, Sarah Nelson, Sharandip K. Nijjar, Rachel Parker, Jonathan West, Ali Tavassoli, Matthew J. J. Rose-Zerilli, Jeremy P. Blaydes. https://stke.sciencemag.org/content/13/630/eaau9529

Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1 – Jianyin Long, Daniel L. Galvan, Koki Mise, Yashpal S. Kanwar, Li Li, Naravat Poungvarin, Paul A. Overbeek, Benny H Chang and Farhad R. Danesh. http://www.jbc.org/content/early/2020/05/28/jbc.RA120.013228.abstract

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion – Aharon Helman, Andrew L. Cangelosi, Jeffrey C. Davis, Quan Pham, Arielle Rothman, Aubrey L. Faust, Juerg R. Straubhaar, David M. Sabatini, Douglas A. Melton. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30186-8

ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila – Sebastian Sorge, Jonas Theelke, Kerem Yildirim, Helen Hertenstein, Ellen McMullen, Stephan Müller, Christian Altbürger, Stefanie Schirmeier, Ingrid Lohmann. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30612-4


IDH


Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism – Di Yu, Yang Liu, Yiqiang Zhou, Victor Ruiz-Rodado, Mioara Larion, Guowang Xu, and Chunzhang Yang. https://www.pnas.org/content/117/18/9964.abstract?etoc


Miscellaneous


Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis [CAD is the deamidase] – Jun Zhao, Mao Tian, Shu Zhang, Alireza Delfarah, Ruoyun Gao, Youliang Rao, Ali Can Savas, Anjie Lu, Larissa Bubb, Xiao Lei, Rosa Moshirian, Wenjie Zhu, Cheng Peng, Taijiao Jiang, Lin Chen, Nicholas A. Graham, Pinghui Feng. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30188-1

Common biochemical properties of metabolic genes recurrently dysregulated in tumors – Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis and Sriram Chandrasekaran. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0211-1

N‐acetyl‐l‐tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals – Takashi Matsumura, Outa Uryu, Fumikazu Matsuhisa, Keiji Tajiri, Hitoshi Matsumoto, Yoichi Hayakawa. https://www.embopress.org/doi/abs/10.15252/embr.201949211

Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation – Accalia Fu, Juan Carlos Alvarez-Perez, Daina Avizonis, Tatsuya Kin, Scott B. Ficarro, Dong Wook Choi, Esra Karakose, Mehmet G. Badur, Lindsay Evans, Carolina Rosselot, Gaelle Bridon, Gregory H. Bird, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jurre J. Kamphorst, Andrew F. Stewart, A. M. James Shapiro, Jarrod A. Marto, Loren D. Walensky, Russell G. Jones, Adolfo Garcia-Ocana and Nika N. Danial. https://www.nature.com/articles/s42255-020-0199-4


Reviews


Advances into understanding metabolites as signaling molecules in cancer progression – Joyce Y. Liu, Kathryn E. Wellen. https://www.sciencedirect.com/science/article/abs/pii/S095506742030020X

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic CellsFernando Erra Díaz, Valeria Ochoa, Antonela Merlotti, Ezequiel Dantas, Ignacio Mazzitelli, Virginia Gonzalez Polo, Juan Sabatté, Sebastián Amigorena, Elodie Segura, Jorge Geffner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30562-3

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions – Jawed A. Siddiqui, Ramesh Pothuraju, Maneesh Jain, Surinder K.Batra, Mohd W.Nasser. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20300159

Cholesterol and beyond – The role of the mevalonate pathway in cancer biology – Andy Göbel, Martina Rauner, Lorenz C. Hofbauer, Tilman D. Rachner. https://www.sciencedirect.com/science/article/abs/pii/S0304419X1930174X

Death by lipids: the role of small nucleolar RNAs in metabolic stress – Jean E. Schaffer. http://www.jbc.org/content/early/2020/05/11/jbc.AW120.011105.abstract

The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance – Margot Riggi, Beata Kusmider and Robbie Loewith. http://jcs.biologists.org/content/133/9/jcs242040?etoc

Metabolic Flux Analysis: Moving beyond Static MetabolomicsSilvia Radenkovic, Ivan Vuckovic, Ian R. Lanza. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30059-1

Folding the Mitochondrial UPR into the Integrated Stress ResponseNadine S. Anderson, Cole M. Haynes. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30055-6

The Complex Interplay between Antioxidants and ROS in Cancer – Isaac S. Harris, Gina M. DeNicola. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30058-1

Emerging Mechanisms and Disease Relevance of Ferroptosis – Brent R. Stockwell, Xuejun Jiang, Wei Gu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30054-4

Reprogramming of serine, glycine and one-carbon metabolism in cancer – Li AM, Ye J. https://pubmed.ncbi.nlm.nih.gov/32439610/

Chromatin as a key consumer in the metabolite economy – Diehl KL, Muir TW. https://www.nature.com/articles/s41589-020-0517-x

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death – Daher B, Vučetić M, Pouysségur J. https://www.frontiersin.org/articles/10.3389/fonc.2020.00723/full


Comments


Glutamine: A bad guy for antitumor immunity? – Lewis Z. Shi. https://stm.sciencemag.org/content/12/542/eabb7093

Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers – G. Aaron Hobbs, Channing J. Der. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30055-4

A BAD portion of glucose can be good for inflamed beta cells – Christian Frezza. https://www.nature.com/articles/s42255-020-0198-5

CLUHing in mitochondria to starvation – Annalisa M. VanHook. https://stke.sciencemag.org/content/13/631/eabc6690

MetaboList – April 2020


Amino acid metabolism


Cysteine depletion induces pancreatic tumor ferroptosis in mice – Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive. https://science.sciencemag.org/content/368/6486/85

Identifying strategies to target the metabolic flexibility of tumours – Andrés Méndez-Lucas, Wei Lin, Paul C. Driscoll, Nathalie Legrave, Laura Novellasdemunt, Chencheng Xie, Mark Charles, Zena Wilson, Neil P. Jones, Stephen Rayport, Manuel Rodríguez-Justo, Vivian Li, James I. MacRae, Nissim Hay, Xin Chen and Mariia Yuneva. https://www.nature.com/articles/s42255-020-0195-8

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma – Kewen Hu, Kun Li, Jing Lv, Jie Feng, Jing Chen, Haigang Wu, Feixiong Cheng, Wenhao Jiang, Jieqiong Wang, Haixiang Pei, Paul J. Chiao, Zhenyu Cai, Yihua Chen, Mingyao Liu, and Xiufeng Pang. https://www.jci.org/articles/view/124049

Serine Catabolism Feeds NADH when Respiration Is Impaired – Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30114-5

ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase – Robert T. Williams, Rohiverth Guarecuco, Leah A. Gates, Douglas Barrows, Maria C. Passarelli, Bryce Carey, Lou Baudrier, Swarna Jeewajee, Konnor La, Benjamin Prizer, Sohail Malik, Javier Garcia-Bermudez, Xiphias Ge Zhu, Jason Cantor, Henrik Molina, Thomas Carroll, Robert G. Roeder, Omar Abdel-Wahab, C. David Allis, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30123-6

EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma – Rui Yang, Xiuxiu Li, Yanan Wu, Guanghui Zhang, Xiaoran Liu, Yanping Li, Yonghua Bao, Wancai Yang and Hongjuan Cui. https://www.nature.com/articles/s41388-020-1199-2

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival – Longfei Deng, Pengbo Yao, Le Li, Fansen Ji, Shuang Zhao, Chang Xu, Xun Lan and Peng Jiang. https://www.nature.com/articles/s41467-020-15573-6

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers – Suman Mukhopadhyay, Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin, Serguei V. Kozlov, Dwight V. Nissley and Frank McCormick. https://cancerres.aacrjournals.org/content/80/8/1630

Interaction of the neutral amino acid transporter ASCT2 with basic amino acids – Elias Ndaru, Rachel-Ann A. Garibsingh, Laura Zielewicz, Avner Schlessinger, Christof Grewer. https://portlandpress.com/biochemj/article/477/8/1443/222575/Interaction-of-the-neutral-amino-acid-transporter


Glucose metabolism


KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer – Hunain Alam, Ming Tang, Mayinuer Maitituoheti, Shilpa S. Dhar, Manish Kumar, Chae Young Han, Chandrashekar R. Ambati, Samir B. Amin, Bingnan Gu, Tsai-Yu Chen, Yu-Hsi Lin, Jichao Chen, Florian L. Muller, Nagireddy Putluri, Elsa R. Flores, Francesco J. DeMayo, Laura Baseler, Kunal Rai, Min Gyu Lee. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30106-9

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3) – D. A. Richardson, P. Sritangos, A. D. James, A. Sultan and J. I. E. Bruce. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0210-2

Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis – Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang and Chunlin Shao. https://link-springer-com.sire.ub.edu/article/10.1007/s11010-020-03729-3

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition – Aaminah Khan, Emanuele Valli, Hayley Lam, David A. Scott, Jayne Murray, Kimberley M. Hanssen, Georgina Eden, Laura D. Gamble, Rupinder Pandher, Claudia L. Flemming, Sophie Allan, Andrei L. Osterman, Michelle Haber, Murray D. Norris, Jamie I. Fletcher and Denise M. T. Yu. https://www.nature.com/articles/s41388-020-1235-2

Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth – Simranjot Bawa, David S Brooks, Kathryn E Neville, Marla Tipping, Md Abdul Sagar, Joseph A Kollhoff, Geetanjali Chawla, Brian V Geisbrecht, Jason M Tennessen, Kevin W Eliceiri, Erika R Geisbrecht. https://elifesciences.org/articles/52358


Lipid metabolism


The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis – Daqian Xu, Zheng Wang, Yan Xia, Fei Shao, Weiya Xia, Yongkun Wei, Xinjian Li, Xu Qian, Jong-Ho Lee, Linyong Du, Yanhua Zheng, Guishuai Lv, Jia-shiun Leu, Hongyang Wang, Dongming Xing, Tingbo Liang, Mien-Chie Hung and Zhimin Lu. https://www.nature.com/articles/s41586-020-2183-2

Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian CancerDaniela Criscuolo, Rosario Avolio, Giovanni Calice, Chiara Laezza, Simona Paladino, Giovanna Navarra, Francesca Maddalena, Fabiana Crispo, Cristina Pagano, Maurizio Bifulco, Matteo Landriscina, Danilo Swann Matassa, Franca Esposito. https://www.mdpi.com/2073-4409/9/4/828

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling – Divya Venkatesh, Nicholas A. O’Brien, Fereshteh Zandkarimi, David R. Tong, Michael E. Stokes, Denise E. Dunn, Everett S. Kengmana, Allegra T. Aron, Alyssa M. Klein, Joleen M. Csuka, Sung-Hwan Moon, Marcus Conrad, Christopher J. Chang, Donald C. Lo, Angelo D’Alessandro, Carol Prives and Brent R. Stockwell. http://genesdev.cshlp.org/content/34/7-8/526.abstract?etoc

Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance – Abir Mukherjee, Chun-Yi Chiang, Helen A. Daifotis, Kristin M. Nieman, Johannes F. Fahrmann, Ricardo R. Lastra, Iris L. Romero, Oliver Fiehn and Ernst Lengyel. https://cancerres.aacrjournals.org/content/80/8/1748


Nucleotides


IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex – Alexander J. Valvezan, Molly C. McNamara, Spencer K. Miller, Margaret E. Torrence, John M. Asara, Elizabeth P. Henske, and Brendan D. Manning. https://insight.jci.org/articles/view/135071

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells – Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic. https://science.sciencemag.org/content/368/6488/283


Mitochondria


IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism – Atsuhito Tsuji, Takumi Akao, Takahiro Masuya, Masatoshi Murai and Hideto Miyoshi. http://www.jbc.org/content/early/2020/04/14/jbc.RA120.013366.abstract

High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung – Mitchell Frederick, Heath D. Skinner, Sawad A. Kazi, Andrew G. Sikora and Vlad C. Sandulache. https://www.nature.com/articles/s41598-020-63448-z


Starvation


Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells – Franziska Püschel, Francesca Favaro, Jaime Redondo-Pedraza, Estefanía Lucendo, Raffaella Iurlaro, Sandrine Marchetti, Blanca Majem, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Eric Chevet, and Cristina Muñoz-Pinedo. https://www.pnas.org/content/early/2020/04/17/1913707117/

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer – Xiaoguang Liu, Kellen Olszewski, Yilei Zhang, Esther W. Lim, Jiejun Shi, Xiaoshan Zhang, Jie Zhang, Hyemin Lee, Pranavi Koppula, Guang Lei, Li Zhuang, M. James You, Bingliang Fang, Wei Li, Christian M. Metallo, Masha V. Poyurovsky and Boyi Gan. https://www.nature.com/articles/s41556-020-0496-x

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11) – Itsuki Yamaguchi, Shige H. Yoshimura and Hironori Katoh. http://www.jbc.org/content/early/2020/04/07/jbc.RA119.012213.abstract

Reorganization of budding yeast cytoplasm upon energy depletion – Guendalina Marinia, Elisabeth Nüskea, Weihua Lenga, Simon Albertia, and Gaia Pigino. https://www.molbiolcell.org/doi/10.1091/mbc.E20-02-0125?ai=25zg&ui=2oy6&af=T


Nutrient sensing/mTOR


Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity – Neeharika Nemani , Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, Karthik Ramachandran, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya SinghMalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Christopher E. Shannon, Warren G. Tourtellotte, Brij B. Singh, W. Brian Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Jonathan Soboloff, Muniswamy Madesh. https://stke.sciencemag.org/content/13/628/eaaz6206

Mitochondrial localization of SESN2 – Irina E Kovaleva, Artem V Tokarchuk, Andrei O Zheltukhin, Alexandra A Dalina, Grigoriy G Safronov, Alexandra G Evstafieva, Konstantin G Lyamzaev, Peter M Chumakov, Andrei V Budanov. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226862

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells – Yeonjin Kim, Mark S. Sundrud, Changqian Zhou, Maja Edenius, Davide Zocco, Kristen Powers, Miao Zhang, Ralph Mazitschek, Anjana Rao, Chang-Yeol Yeo, Erika H. Noss, Michael B. Brenner, Malcolm Whitman, and Tracy L. Keller. https://www.pnas.org/content/117/16/8900.abstract?etoc

The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4 – Thomas D Burton, Anthony O Fedele, Jianling Xie, Lauren Sandeman and Christopher G. Proud. http://www.jbc.org/content/early/2020/04/20/jbc.RA119.011864.abstract

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver – Cédric Gobet, Benjamin Dieter Weger, Julien Marquis, Eva Martin, Nagammal Neelagandan, Frédéric Gachon, and Felix Naef. https://www.pnas.org/content/117/17/9630.abstract?etoc

Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress in Saccharomyces cerevisiae – Imadeddin Hijazi, Jeffrey Knupp and Amy Chang. http://jcs.biologists.org/content/133/6/jcs241539?etoc

A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth – Chase H. Melick, Delong Meng and Jenna L. Jewell. http://www.jbc.org/content/early/2020/04/20/jbc.AC120.012595.abstract


Hypoxia


Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism – Isha H. Jain, Sarah E. Calvo, Andrew L. Markhard, Owen S. Skinner, Tsz-Leung To, Tslil Ast, Vamsi K. Mootha. https://www.cell.com/cell/fulltext/S0092-8674(20)30321-4

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia – Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates III, Sua Myong, John K Kim. https://elifesciences.org/articles/48480

HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α – Peizhan Chen, Xiaohua Duan, Xiaoguang Li, Jingquan Li, Qian Ba and Hui Wang. https://www.nature.com/articles/s41388-020-1190-y


Cancer Immunometabolism


Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages – Pan Su, Qiang Wang, Enguang Bi, Xingzhe Ma, Lintao Liu, Maojie Yang, Jianfei Qian and Qing Yi. https://cancerres.aacrjournals.org/content/80/7/1438

Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy – Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo. https://elifesciences.org/articles/52330

Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment – Prasenjit Dey, Jun Li, Jianhua Zhang, Surendra Chaurasiya, Anders Strom, Huamin Wang, Wen-Ting Liao, Frederick Cavallaro, Parker Denz, Vincent Bernard, Er-Yen Yen, Giannicola Genovese, Pat Gulhati, Jielin Liu, Deepavali Chakravarti, Pingna Deng, Tingxin Zhang, Federica Carbone, Qing Chang, Haoqiang Ying, Xiaoying Shang, Denise J. Spring, Bidyut Ghosh, Nagireddy Putluri, Anirban Maitra, Y. Alan Wang and Ronald A. DePinho. https://cancerdiscovery.aacrjournals.org/content/10/4/608


IDH


Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2 – Ritika Dutta, Tian Yi Zhang, Thomas Köhnke, Daniel Thomas, Miles Linde, Eric Gars, Melissa Stafford, Satinder Kaur, Yusuke Nakauchi, Raymond Yin, Armon Azizi, Anupama Narla, and Ravindra Majeti. https://www.jci.org/articles/view/133344

Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas – Yuxiang Wang , Aaron T. Wild, Sevin Turcan, Wei H. Wu, Carlie Sigel, David S. Klimstra, Xiaoxiao Ma, Yongxing Gong, Eric C. Holland, Jason T. Huse, Timothy A. Chan. https://advances.sciencemag.org/content/6/17/eaaz3221


Miscellaneous


Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis – Katerina Rohlenova, Jermaine Goveia, Melissa García-Caballero, Abhishek Subramanian, Joanna Kalucka, Lucas Treps, Kim D. Falkenberg, Laura P.M.H. de Rooij, Yingfeng Zheng, Lin Lin, Liliana Sokol, Laure-Anne Teuwen, Vincent Geldhof, Federico Taverna, Andreas Pircher, Lena-Christin Conradi, Shawez Khan, Steve Stegen, Dena Panovska, Frederik De Smet, Frank J.T. Staal, Rene J. Mclaughlin, Stefan Vinckier, Tine Van Bergen, Nadine Ectors, Patrik De Haes, Jian Wang, Lars Bolund, Luc Schoonjans, Tobias K. Karakach, Huanming Yang, Geert Carmeliet, Yizhi Liu, Bernard Thienpont, Mieke Dewerchin, Guy Eelen, Xuri Li, Yonglun Luo, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30124-8

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress – Hakjoo Lee, Sylvia B. Smith, Shey-Shing Sheu and Yisang Yoon. https://www.jbc.org/content/early/2020/04/03/jbc.RA119.010983.abstract

Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor – Yejun Zou, Aoxue Wang, Li Huang, Xudong Zhu, Qingxun Hu, Yinan Zhang, Xianjun Chen, Fengwen Li, Qiaohui Wang, Hu Wang, Renmei Liu, Fangting Zuo, Ting Li, Jing Yao, Yajie Qian, Mei Shi, Xiao Yue, Weicai Chen, Zhuo Zhang, Congrong Wang, Yong Zhou, Linyong Zhu, Zhenyu Ju, Joseph Loscalzo, Yi Yang, Yuzheng Zhao. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30144-1

Metabolic Imaging Using Hyperpolarized Pyruvate–Lactate Exchange Assesses Response or Resistance to the EGFR Inhibitor Cetuximab in Patient-Derived HNSCC Xenografts – Lionel Mignion, Stefania Acciardo, Florian Gourgue, Nicolas Joudiou, Xavier Caignet, Rose-Marie Goebbels, Cyril Corbet, Olivier Feron, Caroline Bouzin, Patrice D. Cani, Jean-Pascal Machiels, Sandra Schmitz and Bénédicte F. Jordan. https://clincancerres.aacrjournals.org/content/26/8/1932

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture – Dongqing Zheng, Jonathan H. Sussman, Matthew P. Jeon, Sydney T. Parrish, Melanie A. MacMullan, Alireza Delfarah and Nicholas A. Graham. http://jcs.biologists.org/content/133/7/jcs239277?etoc

GAPDH Delivers Heme to Soluble Guanylyl Cyclase – Yue Dai, Elizabeth A. Sweeny, Simon Schlanger, Arnab Ghosh and Dennis J. Stuehr. http://www.jbc.org/content/early/2020/04/30/jbc.RA120.013802.abstract


Reviews


Metabolic reprogramming and cancer progression – Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis. https://science.sciencemag.org/content/368/6487/eaaw5473

Nitrogen Metabolism in Cancer and ImmunityKiran Kurmi, Marcia C. Haigis. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30040-4 

Metabolic Reprogramming in Tumors: Contributions of the Tumor Microenvironment – Andrew N Lane, Richard M Higashi, Teresa W-M Fan. https://www.sciencedirect.com/science/article/pii/S2352304219300947?via%3Dihub

Enzyme promiscuity, metabolite damage, and metabolite damage control systems of the tricarboxylic acid cycle – Thomas D. Niehaus, Katie B. Hillmann. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15284

The integrated stress response: From mechanism to diseaseMauro Costa-Mattioli, Peter Walter. https://science.sciencemag.org/content/368/6489/eaat5314

A non-proliferative role of pyrimidine metabolism in cancerAarif Siddiqui, Paolo Ceppi. https://www.sciencedirect.com/science/article/pii/S221287782030034X?dgcid=raven_sd_via_email

On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity – Shobbir Hussain. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30069-8

Seminars in Cell & Developmental Biology special issue: Cancer Cells & Therapeutic Targets – Edited by Massimo Donadelli, Chiara Riganti. https://www.sciencedirect.com/journal/seminars-in-cell-and-developmental-biology/vol/98/suppl/C

Including:

Mitochondrial metabolic alterations in cancer cells and related therapeutic targets

Chiara Riganti, Massimo Donadelli

Regulation of succinate dehydrogenase and role of succinate in cancer

Elisa Dalla Pozza, Ilaria Dando, Raffaella Pacchiana, Elio Liboi, … Marta Palmieri

Fumarate hydratase in cancer: A multifaceted tumour suppressor

Christina Schmidt, Marco Sciacovelli, Christian Frezza

The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?

Houda Abla, Manuela Sollazzo, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Porcelli

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

José M. Matés, Floriana J. Di Paola, José A. Campos-Sandoval, Sybille Mazurek, Javier Márquez 

Role of coenzymes in cancer metabolism

Maheshwor Thapa, Guido Dallmann

Exploiting metabolic vulnerabilities of Non small cell lung carcinoma

Blanca Majem, Ernest Nadal, Cristina Muñoz-Pinedo

Metabolic pathways regulating colorectal cancer initiation and progression

Sofia La Vecchia, Carlos Sebastián

Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness

Marina Bacci, Luigi Ippolito, Lucia Magnelli, Elisa Giannoni, Paola Chiarugi

Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?

Joanna Kopecka, Elena Gazzano, Barbara Castella, Iris C. Salaroglio, … Chiara Riganti

The multifaceted effects of metformin on tumor microenvironment

Ivana Kurelac, Nikkitha Umesh Ganesh, Maria Iorio, Anna Maria Porcelli, Giuseppe Gasparre

3D gastrointestinal models and organoids to study metabolism in human colon cancer

Catarina Silva-Almeida, Marie-Ann Ewart, Colin Wilde

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer diseas

Giovanni Blandino, Fabio Valenti, Andrea Sacconi, Silvia Di Agostino 

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond

Daria Capece, Daniela Verzella, Barbara Di Francesco, Edoardo Alesse, … Francesca Zazzeroni

Autophagy and mitophagy in cancer metabolic remodelling

Fabio Ferro, Stéphane Servais, Pierre Besson, Sébastien Roger, … Lucie Brisson

Mitochondria as playmakers of apoptosis, autophagy and senescence

Marianna Abate, Agostino Festa, Michela Falco, Angela Lombardi, … Gabriella Misso

Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer

Saharnaz Sarlak, Claude Lalou, Nivea Dias Amoedo, Rodrigue Rossignol 

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Alessandro Rimessi, Gaia Pedriali, Bianca Vezzani, Anna Tarocco, … Paolo Pinton

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

Tânia Capelôa, Zohra Benyahia, Luca X. Zampieri, Marine C.N.M. Blackman, Pierre Sonveaux

Targeting metabolic reprogramming in metastatic melanoma: The key role of nicotinamide phosphoribosyltransferase (NAMPT)

Valentina Audrito, Antonella Managò, Federica Gaudino, Silvia Deaglio

Reconciling environment-mediated metabolic heterogeneity with the oncogene-driven cancer paradigm in precision oncology

Catherine Vander Linden, Cyril Corbet

From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer

Sepideh Aminzadeh-Gohari, Daniela D. Weber, Silvia Vidali, Luca Catalano, … René G. Feichtinger


Comments


NADH Ties One-Carbon Metabolism to Cellular Respiration – Adam G. Maynard, Naama Kanarek. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30127-3

Why Warburg Works: Lactate Controls Immune Evasion through GPR81 – Kathrine Lundø, Mette Trauelsen, Stine F. Pedersen, Thue W. Schwartz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30116-9

FABP4: A New Player in Obesity-Associated Breast Cancer – Jun Zeng, Edward R. Sauter, Bing Li. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30076-9

MetaboList – March 2020

 

Research is important. Keep strong everyone

 


Mitochondria


Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway – Xiaoyan Guo, Giovanni Aviles, Yi Liu, Ruilin Tian, Bret A. Unger, Yu-Hsiu T. Lin, Arun P. Wiita, Ke Xu, M. Almira Correia and Martin Kampmann. https://www.nature.com/articles/s41586-020-2078-2

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol – Evelyn Fessler, Eva-Maria Eckl, Sabine Schmitt, Igor Alves Mancilla, Matthias F. Meyer-Bender, Monika Hanf, Julia Philippou-Massier, Stefan Krebs, Hans Zischka and Lucas T. Jae. https://www.nature.com/articles/s41586-020-2076-4

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation – Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger and Helmut Klocker. https://www.nature.com/articles/s41467-020-15237-5

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition – Aurélie Morin, Judith Goncalves, Sophie Moog, Luis-Jaime Castro-Vega, Sylvie Job, Alexandre Buffet, Marie-Joséphine Fontenille, Justine Woszczyk, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Judith Favier. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30329-6

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z


Nutirent sensing / starvation


Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression – Niklas Mejhert, Leena Kuruvilla, Katlyn R. Gabriel, Shane D. Elliott, Marie-Aude Guie, Huajin Wang, Zon Weng Lai, Elizabeth A. Lane, Romain Christiano, Nika N. Danial, Robert V. Farese Jr., Tobias C. Walther. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30014-9

The role of Rsv1 in the transcriptional regulation of genes involved in sugar metabolism for long‐term survival [yeast] – Eun‐Jung Kim, Yong‐Joon Cho, Woo‐Hyun Chung, Jung‐Hye Roe. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15052

Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1 [yeast] – Triana Amen, Daniel Kaganovich. https://stke.sciencemag.org/content/13/623/eaaz6339

Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restrictionElena Clementi, Larissa Inglin, Erin Beebe, Corina Gsell, Zuzana Garajova and Enni Markkanen. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-020-00771-x 


AMPK / mTOR


Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability – Anders P. Mutvei, Michal J. Nagiec, Jens C. Hamann, Sang Gyun Kim, C. Theresa Vincent and John Blenis. https://www.nature.com/articles/s41467-020-15156-5

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System – Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R. Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30958-X


Cancer Immunometabolism


Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity – Hermans D, Gautam S, García-Cañaveras JC, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin JX, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers LM, Rabinowitz JD, Gattinoni L, Leonard WJ. https://doi.org/10.1073/pnas.1920413117

Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma – Arghya Ray, Yan Song, Ting Du, Dharminder Chauhan and Kenneth C. Anderson. https://www.nature.com/articles/s41388-020-1172-0


Miscellaneous


Metabolic Reprogramming in Cancer Is Induced to Increase Proton Production – Huiyan Sun, Yi Zhou, Michael Francis Skaro, Yiran Wu, Zexing Qu, Fenglou Mao, Suwen Zhao and Ying Xu. https://cancerres.aacrjournals.org/content/80/5/1143

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPCRobinson Arce-Molina, Francisca Cortés-Molina, Pamela Y Sandoval, Alex Galaz, Karin Alegría, Stefanie Schirmeier, L Felipe Barros, Alejandro San Martín. https://elifesciences.org/articles/53917

Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3


Glucose metabolism


Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion – R. Commander, C. Wei, A. Sharma, J. K. Mouw, L. J. Burton, E. Summerbell, D. Mahboubi, R. J. Peterson, J. Konen, W. Zhou, Y. Du, H. Fu, M. Shanmugam and A. I. Marcus. https://www.nature.com/articles/s41467-020-15219-7

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer – Qingjian Li, Tao Qin, Zhuofei Bi, Huangming Hong, Lin Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Man-Li Luo, Phei Er Saw, Gerburg M. Wulf, Xiaoding Xu, Erwei Song, Herui Yao and Hai Hu. https://www.nature.com/articles/s41467-020-15308-7

Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2Suparno Nandi and Mishtu Dey. http://www.jbc.org/content/early/2020/03/06/jbc.RA120.013030.abstract 

Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis – Yun-feng Guan, Qiao-ling Huang, Yuan-li Ai, Qi-tao Chen, Wen-xiu Zhao, Xiao-min Wang, Qiao Wu and Hang-zi Chen. https://www-nature-com.sire.ub.edu/articles/s41388-020-1158-y


PFKFB3


Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3 – Andrew J. Robinson, Goitseone L. Hopkins, Namrata Rastogi, Marie Hodges, Michelle Doyle, Sara Davies, Paul S. Hole, Nader Omidvar, Richard L. Darley and Alex Tonks. https://cancerres.aacrjournals.org/content/80/5/937

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3 – Huanhuan Ma, Jia Zhang, Lin Zhou, Shixiong Wen, Hsiang-Yu Tang, Bin Jiang, Fengqiong Zhang, Muhammad Suleman, Dachao Sun, Ai Chen, Wentao Zhao, Furong Lin, Ming-Tong Tsau, Lu-Min Shih, Changchuan Xie, Xiaotong Li, Donghai Lin, Li-Man Hung, Mei-Ling Cheng, Qinxi Li. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30303-X

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming – Jia Liu, Ze-Xian Liu, Qi-Nian Wu, Yun-Xin Lu, Chau-Wei Wong, Lei Miao, Yun Wang, Zixian Wang, Ying Jin, Ming-Ming He, Chao Ren, De-Shen Wang, Dong-Liang Chen, Heng-Ying Pu, Lin Feng, Bo Li, Dan Xie, Mu-Sheng Zeng, Peng Huang, Aifu Lin, Dongxin Lin, Rui-Hua Xu and Huai-Qiang Ju. https://www.nature.com/articles/s41467-020-15112-3


Glutamine metabolism and restriction


A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer – Manabu Kodama, Kiyotaka Oshikawa, Hideyuki Shimizu, Susumu Yoshioka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Chisa Tateishi, Takeshi Tomonaga, Masaki Matsumoto and Keiichi I. Nakayama. https://www.nature.com/articles/s41467-020-15136-9

Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma – L. Ren, V. Ruiz-Rodado, T. Dowdy, S. Huang, S. H. Issaq, J. Beck, H. Wang, C. Tran Hoang, A. Lita, M. Larion and A. K. LeBlanc. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0209-8

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers – Suman Mukhopadhyay, Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin, Serguei V. Kozlov, Dwight V. Nissley and Frank McCormick. https://cancerres.aacrjournals.org/content/early/2020/02/23/0008-5472.CAN-19-1363

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer – Thai Q. Tran, Eric A. Hanse, Amber N. Habowski, Haiqing Li, Mari B. Ishak Gabra, Ying Yang, Xazmin H. Lowman, Amelia M. Ooi, Shu Y. Liao, Robert A. Edwards, Marian L. Waterman and Mei Kong. https://www.nature.com/articles/s43018-020-0035-5


Other amino acids


Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism – Albert M. Li, Gregory S. Ducker, Yang Li, Jose A. Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E. Graves, Erinn B. Rankin, Christina Curtis, Joan Massagué, Joshua D. Rabinowitz, Craig B. Thompson, Jiangbin Ye. https://mcr.aacrjournals.org/content/early/2020/01/15/1541-7786.MCR-19-0606

Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells – Białopiotrowicz E, Noyszewska-Kania M, Kachamakova-Trojanowska N, Łoboda A, Cybulska M, Grochowska A, Kopczyński M, Mikula M, Prochorec-Sobieszek M, Firczuk M, Graczyk-Jarzynka A, Zagożdżon R, Ząbek A, Młynarz P, Dulak J, Górniak P, Szydłowski M, Pyziak K, Martyka J, Sroka-Porada A, Jabłońska E, Polak A, Kowalczyk P, Szumera-Ciećkiewicz A, Chapuy B, Rzymski T, Brzózka K, Juszczyński P. https://doi.org/10.3390/cancers12030580

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma – Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W. https://link.springer.com/article/10.1007%2Fs00018-020-03483-1

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy – Renee C. Geck, Jackson R. Foley, Tracy Murray Stewart, John M. Asara, Robert A. Casero Jr. and Alex Toker. http://www.jbc.org/content/early/2020/03/05/jbc.RA119.012376.abstract

Cancer progression is mediated by proline catabolism in non-small cell lung cancer – Yating Liu, Chao Mao, Min Wang, Na Liu, Lianlian Ouyang, Shouping Liu, Haosheng Tang, Ya Cao, Shuang Liu, Xiang Wang, Desheng Xiao, Ceshi Chen, Ying Shi, Qin Yan & Yongguang Tao. https://www.nature.com/articles/s41388-019-1151-5


Lipid metabolism


Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells – Emily Clement, Ikrame Lazar, Camille Attané, Lorry Carrié, Stéphanie Dauvillier, Manuelle Ducoux‐Petit, David Esteve, Thomas Menneteau, Mohamed Moutahir, Sophie Le Gonidec, Stéphane Dalle, Philippe Valet, Odile Burlet‐Schiltz, Catherine Muller, Laurence Nieto. https://www.embopress.org/doi/abs/10.15252/embj.2019102525

Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma – Elizabeth C. Randall, Begoña G.C. Lopez, Sen Peng, Michael S. Regan, Walid M. Abdelmoula, Sankha S. Basu, Sandro Santagata, Haejin Yoon, Marcia C. Haigis, Jeffrey N. Agar, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria and Nathalie Y.R. Agar. https://cancerres.aacrjournals.org/content/80/6/1258

The MEK5–ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer – Sandra Cristea, Garry L. Coles, Daniel Hornburg, Maya Gershkovitz, Julia Arand, Siqi Cao, Triparna Sen, Stuart C. Williamson, Jun W. Kim, Alexandros P. Drainas, Andrew He, Laurent Le Cam, Lauren Averett Byers, Michael P. Snyder, Kévin Contrepois and Julien Sage. https://cancerres.aacrjournals.org/content/80/6/1293

Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis – Li Gu, Yahui Zhu, Xi Lin, Xingyu Tan, Bingjun Lu and Youjun Li. https://www.nature.com/articles/s41388-020-1156-0


Nucleotides and NADPH


MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis – Chien-Kuang Cornelia Ding, Joshua Rose, Tianai Sun, Jianli Wu, Po-Han Chen, Chao-Chieh Lin, Wen-Hsuan Yang, Kai-Yuan Chen, Hana Lee, Emily Xu, Sarah Tian, Jadesola Akinwuntan, Jinshi Zhao, Ziqiang Guan, Pei Zhou and Jen-Tsan Chi. https://www.nature.com/articles/s42255-020-0181-1

Macropinocytosis confers resistance to therapies targeting cancer anabolism – Vaishali Jayashankar and Aimee L. Edinger. https://www.nature.com/articles/s41467-020-14928-3

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors – Sona Hubackova, Eliska Davidova, Stepana Boukalova, Jaromira Kovarova, Martina Bajzikova, Ana Coelho, Mikkel G. Terp, Henrik J. Ditzel, Jakub Rohlena and Jiri Neuzil. https://www.nature.com/articles/s41419-020-2224-7

UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism – Xing Feng, Dong Ma, Jiabao Zhao, Yongxi Song, Yuekun Zhu, Qingxin Zhou, Fei Ma, Xing Liu, Mengya Zhong, Yu Liu, Yubo Xiong, Xingfeng Qiu, Zhen Zhang, Heng Zhang, Yongxiang Zhao, Kaiguang Zhang, Xuehui Hong, Zhiyong Zhang. https://www.embopress.org/doi/abs/10.15252/embj.2019102541


Hypoxia / pseudohypoxia


TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition – Aurélie Morin, Judith Goncalves, Sophie Moog, Luis-Jaime Castro-Vega, Sylvie Job, Alexandre Buffet, Marie-Joséphine Fontenille, Justine Woszczyk, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Judith Favier. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30329-6

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia – Yang Li, Joshua J. Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Lori S. Hart, John M. Maris, Howard Y. Chang, Amato J. Giaccia, Jiangbin Ye. https://www.nature.com/articles/s41419-020-2303-9


Reviews


Dietary modifications for enhanced cancer therapyNaama Kanarek, Boryana Petrova and David M. Sabatini. https://www.nature.com/articles/s41586-020-2124-0 

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer – Benjamin D. Hopkins, Marcus D. Goncalves and Lewis C. Cantley. https://www.nature.com/articles/s41574-020-0329-9

The PHGDH enigma: do cancer cells only need serine or also a redox modulator? – Albert M. Li and Jiangbin Ye. https://www.sciencedirect.com/science/article/pii/S0304383520300501

Ketogenic diet in the treatment of cancer – Where do we stand?Daniela D. Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G. Feichtinger, Barbara Kofler. https://www.sciencedirect.com/science/article/pii/S2212877819304272 

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control – Asier González, Michael N. Hall, Sheng-Cai Lin, D. Grahame Hardie. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30058-9

mTOR Regulation of Metabolism in Hematologic MalignanciesSimone Mirabilii, Maria Rosaria Ricciardi and Agostino Tafuri. https://www.mdpi.com/2073-4409/9/2/404

Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen – Safak Bayram, Susanne Fürst, Martin Forbes, Stefan Kempa. https://www.sciencedirect.com/science/article/pii/S2212877819309536

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer – Matthieu Lacroix, Romain Riscal, Giuseppe Arena, Laetitia Karine Linares, Laurent Le Cam. https://www.sciencedirect.com/science/article/pii/S2212877819309214

Formate metabolism in health and disease – Matthias Pietzke, Johannes Meiser, Alexei Vazquez. https://www.sciencedirect.com/science/article/pii/S2212877819304314

Monocarboxylate transporters in cancerValéry L. Payen, Erica Mina, Vincent F. Van Hée, Paolo E. Porporato, Pierre Sonveaux. https://www.sciencedirect.com/science/article/pii/S221287781930403X 

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion – Peter Kreuzaler, Yulia Panina, Joanna Segal, Mariia Yuneva. https://www.sciencedirect.com/science/article/pii/S2212877819309068

IGFBP2: integrative hub of developmental and oncogenic signaling network – Tao Li, M. Elizabeth Forbes, Gregory N. Fuller, Jiabo Li, Xuejun Yang and Wei Zhang. https://www.nature.com/articles/s41388-020-1154-2

mTOR at the nexus of nutrition, growth, ageing and disease – Grace Y. Liu and David M. Sabatini. https://www.nature.com/articles/s41580-019-0199-y


Comments


Restraining colorectal cancer with αKG – Dana Krauß and Eyal Gottlieb. https://www.nature.com/articles/s43018-020-0044-4

Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved! – Massimo M.Santoro. https://www.sciencedirect.com/science/article/abs/pii/S1550413119306722

Cancer metabolism – An updateAlmut Schulze. https://www.sciencedirect.com/science/article/pii/S2212877819309494 

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

Metabolite Imaging at the Margin: Visualizing Metabolic Tumor Gradients Using Mass Spectrometry – Ai Wen Tan and Aalim M. Weljie. https://cancerres.aacrjournals.org/content/80/6/1231

Mitochondrial distress call moves to the cytosol to trigger a response to stress – Bradford P. Tremblay and Cole M. Haynes. https://www.nature.com/articles/d41586-020-00552-0

A new adaptation strategy to glucose starvation: modulation of the gluconate shunt and pentose phosphate pathway by the transcriptional repressor Rsv1Rodrigo Fraile, Laura Sánchez‐Mir, Elena Hidalgo. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15131 

Trimming the “fatty” intratumoral Tregs for cancer immunotherapy – Lewis Z. Shi. https://stm.sciencemag.org/content/12/534/eabb2770

Stress fibres fuel glycolysis – Joseph Willson. https://www.nature.com/articles/s41580-020-0224-1

MetaboList – February 2020

 


Glucose metabolism


Mechanical regulation of glycolysis via cytoskeleton architecture – Jin Suk Park, Christoph J. Burckhardt, Rossana Lazcano, Luisa M. Solis, Tadamoto Isogai, Linqing Li, Christopher S. Chen, Boning Gao, John D. Minna, Robert Bachoo, Ralph J. DeBerardinis and Gaudenz Danuser. https://www.nature.com/articles/s41586-020-1998-1

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy – Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30054-1

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway – Michael M. Dubreuil, David W. Morgens, Kanji Okumoto, Masanori Honsho, Kévin Contrepois, Brittany Lee-McMullen, Gavin McAllister Traber, Ria S. Sood, Scott J. Dixon, Michael P. Snyder, Yukio Fujiki, Michael C. Bassik. https://www.sciencedirect.com/science/article/pii/S221112472030022X

Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway – Caihong Wang, Shaosen Zhang, Jie Liu, Yang Tian, Boyuan Ma, Siran Xu, Yan Fu, Yongzhang Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30052-8

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing – Lili Yu, Jinchul Kim, Lei Jiang, Bingbing Feng, Yue Ying, Kai-yuan Ji, Qingshuang Tang, Wancheng Chen, Taoyi Mai, Wenlong Dou, Jianlong Zhou, Le-yang Xiang, Yang-fan He, Dinghua Yang, Qingjiao Li, Xuemei Fu and Yang Xu. https://www.nature.com/articles/s41467-020-14437-3

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis – Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann and Martin S. Denzel. https://www.nature.com/articles/s41467-020-14524-5

GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling – Wen-Lian Chen, Xing Jin, Mingsong Wang, Dan Liu, Qin Luo, Hechuan Tian, Lili Cai, Lifei Meng, Rui Bi, Lei Wang, Xiao Xie, Guanzhen Yu, Lihui Li, Changsheng Dong, Qiliang Cai, Wei Jia, Wenyi Wei and Lijun Jia. https://insight.jci.org/articles/view/131596#

CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells – Samantha Ames, Jacob T. Andring, Robert McKenna and Holger M. Becker. https://www.nature.com/articles/s41388-019-1098-6


ROS / Amino acids


Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids – Sarah E. LeBoeuf, Warren L. Wu, Triantafyllia R. Karakousi, Burcu Karadal, S. RaElle Jackson, Shawn M. Davidson, Kwok-Kin Wong, Sergei B. Koralov, Volkan I. Sayin, Thales Papagiannakopoulos. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30619-9

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer – Eric C. Cheung, Gina M. DeNicola, Colin Nixon, Karen Blyth, Christiaan F. Labuschagne, David A. Tuveson, Karen H. Vousden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30582-3


Lipid metabolism


Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis  – Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi and Hei Sook Sul. https://www.nature.com/articles/s41467-020-14617-1

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects – Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes. https://www.pnas.org/content/117/8/4158.abstract?etoc


Mitochondria


Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier – Claire L. Bensard, Dona R. Wisidagama, Kristofor A. Olson, Jordan A. Berg, Nathan M. Krah, John C. Schell, Sara M. Nowinski, Sarah Fogarty, Alex J. Bott, Peng Wei, Katja K. Dove, Jason M. Tanner, Vanja Panic, Ahmad Cluntun, Sandra Lettlova, Christian S. Earl, David F. Namnath, Karina Vázquez-Arreguín, Claudio J. Villanueva, Dean Tantin, L. Charles Murtaugh, Kimberley J. Evason, Gregory S. Ducker, Carl S. Thummel, Jared Rutter. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30609-6

A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism – Jiujie Cui, Ming Quan, Dacheng Xie, Yong Gao, Sushovan Guha, Michael B. Fallon, Jingde Chen and Keping Xie. https://www.nature.com/articles/s41388-019-1051-8

The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation – Marciano R, David HB, Akabayov B, Rotblat B. https://www.mdpi.com/1422-0067/21/3/1041


Starvation / AMPK


Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease – Fan Jia, Congwu Chi, Min Han. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30075-9

Energy-stress-mediated AMPK activation inhibits ferroptosis – Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell and Boyi Gan. https://www.nature.com/articles/s41556-020-0461-8

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise – Yang Liu, Phong T. Nguyen, Xun Wang, Yuting Zhao, Corbin E. Meacham, Zhongju Zou, Bogdan Bordieanu, Manuel Johanns, Didier Vertommen, Tobias Wijshake, Herman May, Guanghua Xiao, Sanae Shoji-Kawata, Mark H. Rider, Sean J. Morrison, Prashant Mishra and Beth Levine. https://www.nature.com/articles/s41586-020-1992-7


mTOR


Glutamine and asparagine activate mTORC1 independently of Rag GTPases – Delong Meng, Qianmei Yang, Huanyu Wang, Chase H. Melick, Rishika Navlani, Anderson R. Frank and Jenna L. Jewell. http://www.jbc.org/content/early/2020/02/04/jbc.AC119.011578.abstract

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control – Wenjian Gan, Xiaoming Dai, Xiangpeng Dai, Jun Xie, Shasha Yin, Junjie Zhu, Chen Wang, Yuchen Liu, Jianping Guo, Min Wang, Jing Liu, Jia Hu, Ryan J. Quinton, Neil J. Ganem, Pengda Liu, John M. Asara, Pier Paolo Pandolfi, Yingzi Yang, Zhigang He, Guangping Gao and Wenyi Wei. https://www.nature.com/articles/s41556-020-0463-6

DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals – Xiaoyu Chen, Xiufang Xiong, Danrui Cui, Fei Yang, Dongping Wei, Haomin Li, Jianfeng Shu, Yanli Bi, Xiaoqing Dai, Longyuan Gong, Yi Sun and Yongchao Zhao. https://www.nature.com/articles/s41388-019-1085-y

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition – Evdokia Michalopoulou, Francesca R. Auciello, Vinay Bulusu, David Strachan, Andrew D. Campbell, Jacqueline Tait-Mulder, Saadia A. Karim, Jennifer P. Morton, Owen J. Sansom, Jurre J. Kamphorst. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30105-4


Hypoxia


NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC – Prashant V. Bommi, Vaibhav Chand, Nishit K. Mukhopadhyay, Pradip Raychaudhuri and Srilata Bagchi. https://www.nature.com/articles/s41388-019-1105-y


Metformin, phenformin


GDF15 mediates the effects of metformin on body weight and energy balance – Anthony P. Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John A. Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A. Goldspink, Emily L. Miedzybrodzka, Adam R. Konopka, Raul Ruiz Esponda, Jeffrey T.-J. Huang, Y. C. Loraine Tung, Sergio Rodriguez-Cuenca, Rute A. Tomaz, Heather P. Harding, Audrey Melvin, Giles S. H. Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, K. Sreekumaran Nair, Nicholas J. Wareham, David Ron, Fiona M. Gribble, Frank Reimann, Naveed Sattar, David B. Savage, Bernard B. Allan and Stephen O’Rahilly. https://www.nature.com/articles/s41586-019-1911-y

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module – Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30033-4

Metformin Abrogates Age-Associated Ovarian Fibrosis – Curtis W. McCloskey, David P. Cook, Brendan S. Kelly, Feryel Azzi, Christian H. Allen, Amanda Forsyth, Jeremy Upham, Katey J. Rayner, Douglas A. Gray, Robert W. Boyd, Sangeeta Murugkar, Bryan Lo, Dominique Trudel, Mary K. Senterman and Barbara C. Vanderhyden. https://clincancerres.aacrjournals.org/content/26/3/632


Cancer Immunometabolism


CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors – Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius and Ping-Chih Ho. https://www.nature.com/articles/s41590-019-0589-5

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade – Daniel Ajona, Sergio Ortiz-Espinosa, Teresa Lozano, Francisco Exposito, Alfonso Calvo, Karmele Valencia, Miriam Redrado, Ana Remírez, Fernando Lecanda, Diego Alignani, Juan J. Lasarte, Irati Macaya, Yaiza Senent, Cristina Bértolo, Cristina Sainz, Ignacio Gil-Bazo, Iñaki Eguren-Santamaría, Jose M. Lopez-Picazo, Alvaro Gonzalez, Jose L. Perez-Gracia, Carlos E. de Andrea, Silvestre Vicent, Miguel F. Sanmamed, Luis M. Montuenga and Ruben Pio. https://www.nature.com/articles/s43018-019-0007-9

Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s – Marek Wagner, Kafi N. Ealey, Hiroe Tetsu, Tsuyoshi Kiniwa, Yasutaka Motomura, Kazuyo Moro, Shigeo Koyasu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30137-6


Reviews


Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer – Sharanya Sivanand, Matthew G. Vander Heiden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30581-1?dgcid=raven_jbs_etoc_email

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo – Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30263-4

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis – Guido T. Bommer, Emile Van Schaftingen, Maria Veiga-da-Cunha. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30176-8

Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment? – Ainhoa Madariaga, Pamela J. Goodwin and Amit M. Oza. https://clincancerres.aacrjournals.org/content/26/3/523

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism – Jonathan J. Ruprecht, Edmund R.S. Kunji. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30229-4

Cell cycle regulators in cancer cell metabolism – Leal-Esteban LC, Fajas L. https://www.sciencedirect.com/science/article/abs/pii/S0925443920300600

Mitochondrial functions and rare diseases – L.Dard, W.Blanchard, C.Hubert, D.Lacombe, R.Rossignol. https://www.sciencedirect.com/science/article/pii/S0098299719301177

Mechanistic Links between Obesity, Insulin, and Cancer – Rachel J. Perry, Gerald I. Shulman. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30261-4

Metabolic Regulation of Cell Fate and Function – Shohini Ghosh-Choudhary, Jie Liu, Toren Finkel. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30219-3

Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma – Erhu Zhao, Jianbing Hou and Hongjuan Cui. https://www.nature.com/articles/s41389-020-0200-9

Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities – Binlu Huang, Bao-liang Song and Chenqi Xu. https://www.nature.com/articles/s42255-020-0174-0


Comments


We need to talk about the Warburg effect – Ralph J. DeBerardinis and Navdeep S. Chandel. https://www.nature.com/articles/s42255-020-0172-2

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects – Sarah-Maria Fendt, Sophia Y. Lunt. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30048-9

Dietary Methionine in T Cell Biology and Autoimmune Disease – Shuang Tang, Xiaoling Li, Jason W. Locasale. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30007-3

Glucose Starvation Blocks Translation at Multiple Levels – Chen-Song Zhang, D. Grahame Hardie, Sheng-Cai Lin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30005-X

Tension in tumour cells keeps metabolism high – Nadia M. E. Ayad, Valerie M. Weaver. https://www.nature.com/articles/d41586-020-00314-y

Histone Lactylation: A New Role for Glucose Metabolism – Maria V. Liberti, Jason W. Locasale. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30265-8

Surviving stress during metastasis – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-0243-4

Starving tumours – Anna Dart. https://www.nature.com/articles/s41568-020-0244-3

Mechanosensing metabolically moves cancer cells – Wei Wong. https://stke.sciencemag.org/content/13/619/eabb2935

An SLC1A5 Variant Transports Glutamine to Mitochondria in Cancer Cells – https://cancerdiscovery.aacrjournals.org/content/10/2/173.2

Isoform-Specific KRAS–Hexokinase 1 Interaction Affects Metabolism – https://cancerdiscovery.aacrjournals.org/content/10/2/OF10

MetaboList – January 2020

 


Starvation / nutrient sensing


Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 – Ina Yoon, Miso Nam, Hoi Kyoung Kim, Hee-Sun Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, Seongmin Cho, YounHa Kim, Jihye Lee, Won Suk Yang, Hee Chan Yoo, Kibum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, Geum-Sook Hwang, Kwang Yeon Hwang, Jung Min Han, Jong Hyun Kim, Sunghoon Kim. https://science.sciencemag.org/content/367/6474/205

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy – Maximilian Schütter, Patrick Giavalisco, Susanne Brodesser, Martin Graef. https://www.cell.com/cell/fulltext/S0092-8674(19)31331-5

Glucose stimulates microRNA-199 expression in murine pancreatic β-cells – Joao Pedro Werneck-de-Castro, Manuel Blandino-Rosano, Denise Hilfiker-Kleiner and Ernesto Bernal-Mizrachi. http://www.jbc.org/content/early/2019/12/26/jbc.RA119.010356.abstract

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila – Kenneth Kin Lam Wong, Ta-Wei Liu, Jessica M. Parker, Donald A. R. Sinclair, Yi-Yun Chen, Kay-Hooi Khoo, David J. Vocadlo and Esther M. Verheye.
https://www.pnas.org/content/117/4/2004.abstract?etoc


mTOR


Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs – Dritan Liko, Andrzej Rzepiela, Vanja Vukojevic, Mihaela Zavolan and Michael N. Hall. https://www.pnas.org/content/117/3/1524.abstract?etoc

Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria – Eisha Shaw, Manasi Talwadekar, Zeenat Rashida, Nitya Mohan, Aishwarya Acharya, Subhash Khatri, Sunil Laxman and Ullas Kolthur-Seetharam. http://mcb.asm.org/content/40/2/e00212-19.abstract?etoc

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation – Ying-Nan Wang, Yun-Xin Lu, Jie Liu, Ying Jin, Hui-Chang Bi, Qi Zhao, Ze-Xian Liu, Ying-Qin Li, Jia-Jia Hu, Hui Sheng, Yi-Ming Jiang, Chao Zhang, Feng Tian, Yang Chen, Zhi-Zhong Pan, Gong Chen, Zhao-Lei Zeng, Kai-Yan Liu, Marcia Ogasawara, Jin-Ping Yun, Huai-Qiang Ju, Jian-Xiong Feng, Dan Xie, Song Gao, Wei-Hua Jia, Scott Kopetz, Rui-Hua Xu and Feng Wang. https://www.nature.com/articles/s41388-019-1004-2

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress – Naomi X. Y. Ling, Adrian Kaczmarek, Ashfaqul Hoque, Elizabeth Davie, Kevin R. W. Ngoei, Kaitlin R. Morrison, William J. Smiles, Gabriella M. Forte, Tingting Wang, Shervi Lie, Toby A. Dite, Christopher G. Langendorf, John W. Scott, Jonathan S. Oakhill and Janni Petersen. https://www.nature.com/articles/s42255-019-0157-1

A two-pore channel protein required for regulating mTORC1 activity on starvation – Fu-Sheng Chang, Yuntao Wang, Phillip Dmitriev, Julian Gross, Antony Galione and Catherine Pears [Dictyostelium]. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0735-4

Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis – Pengfei Cao, Sang-Jin Kim, Anqi Xing, Craig A Schenck, Lu Liu, Nan Jiang, Jie Wang, Robert L Last, Federica Brandizzi. https://elifesciences.org/articles/50747


Glucose metabolism


Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy – Nikita S. Sharma, Vineet K. Gupta, Vanessa T. Garrido, Roey Hadad, Brittany C. Durden, Kousik Kesh, Bhuwan Giri, Anthony Ferrantella, Vikas Dudeja, Ashok Saluja and Sulagna Banerjee. https://www.jci.org/articles/view/127515

A synthetic lethal drug combination mimics glucose deprivation-induced cancer cell death in the presence of glucose – James H Joly, Alireza Delfarah, Philip S Phung, Sydney Parrish and Nicholas A. Graham. http://www.jbc.org/content/early/2019/12/30/jbc.RA119.011471.abstract

O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth – Jay Prakash Singh, Kevin Qian, Jeong-Sang Lee, Jinfeng Zhou, Xuemei Han, Bichen Zhang, Qunxiang Ong, Weiming Ni, Mingzuo Jiang, Hai-Bin Ruan, Min-Dian Li, Kaisi Zhang, Zhaobing Ding, Philip Lee, Kamini Singh, Jing Wu, Raimund I. Herzog, Susan Kaech, Hans-Guido Wendel, John R. Yates III, Weiping Han, Robert S. Sherwin, Yongzhan Nie and Xiaoyong Yang. https://www.nature.com/articles/s41388-019-0975-3

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1 – Kristin L. Granlund, Sui-Seng Tee, Hebert A. Vargas, Serge K. Lyashchenko, Ed Reznik, Samson Fine, Vincent Laudone, James A. Eastham, Karim A. Touijer, Victor E. Reuter, Mithat Gonen, Ramon E. Sosa, Duane Nicholson, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb, Hedvig Hricak, Kayvan R. Keshari. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30498-X


Amino acids


Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy – Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl and Costas A. Lyssiotis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0202-2

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells – Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez and Sophia Y. Lunt. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0205-z

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy – Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero Jr. and Dominic J. Smiraglia. https://www.nature.com/articles/s41467-019-13950-4

Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine – Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Keisuke Kawasaki, Yumiko Hori, Moyu Taniguchi, Yutaka Umakoshi, Daisuke Okuzaki, Naoki Wada, Jun-ichiro Ikeda, Eiichiro Fukusaki and Eiichi Morii. https://www.nature.com/articles/s42255-019-0156-2


Lipid metabolism / Statins


Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress – Irem Kaymak, Carina R. Maier, Werner Schmitz, Andrew D. Campbell, Beatrice Dankworth, Carsten P. Ade, Susanne Walz, Madelon Paauwe, Charis Kalogirou, Hecham Marouf, Mathias T. Rosenfeldt, David M. Gay, Grace H. McGregor, Owen J. Sansom and Almut Schulze. https://cancerres.aacrjournals.org/content/80/2/189

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response – Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J. Sansom and Jurre J. Kamphorst. https://cancerres.aacrjournals.org/content/80/2/175

Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer – Joanna M. Karasinska, James T. Topham, Steve E. Kalloger, Gun Ho Jang, Robert E. Denroche, Luka Culibrk, Laura M. Williamson, Hui-Li Wong, Michael K.C. Lee, Grainne M. O’Kane, Richard A. Moore, Andrew J. Mungall, Malcolm J. Moore, Cassia Warren, Andrew Metcalfe, Faiyaz Notta, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf and David F. Schaeffer. https://clincancerres.aacrjournals.org/content/26/1/135

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer – Jessica C. Casciano, Caroline Perry, Adam J. Cohen-Nowak, Katelyn D. Miller, Johan Vande Voorde, Qifeng Zhang, Susan Chalmers, Mairi E. Sandison, Qin Liu, Ann Hedley, Tony McBryan, Hsin-Yao Tang, Nicole Gorman, Thomas Beer, David W. Speicher, Peter D. Adams, Xuefeng Liu, Richard Schlegel, John G. McCarron, Michael J. O. Wakelam, Eyal Gottlieb, Andrew V. Kossenkov and Zachary T. Schug. https://www.nature.com/articles/s41416-019-0711-3

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response – Yagmur Micoogullari, Sankha S. Basu, Jessie Ang, Nina Weisshaar, Nicholas D. Schmitt, Walid M. Abdelmoula, Begona Lopez, Jeffrey N. Agar, Nathalie Agar and John Hanna. https://www.molbiolcell.org/doi/10.1091/mbc.E19-07-0392?ai=s5&ui=2oy6&af=T

Deciphering the Elevated Lipid via CD36 in Mantle Cell Lymphoma with Bortezomib Resistance Using Synchrotron-Based Fourier Transform Infrared Spectroscopy of Single Cells – Sudjit Luanpitpong ,Montira Janan ,Kanjana Thumanu , Jirarat Poohadsuan ,Napachai Rodboon , Phatchanat Klaihmon and Surapol Issaragrisil. https://doi.org/10.3390/cancers11040576


Mitochondria


A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells – Hee Chan Yoo, Seung Joon Park, Miso Nam, Juwon Kang, Kibum Kim, Joo Hye Yeo, Joon-Ki Kim, Yunkyung Heo, Hee Seung Lee, Myeong Youl Lee, Chang Woo Lee, Jong Soon Kang, Yun-Hee Kim, Jinu Lee, Junjeong Choi, Geum-Sook Hwang, Seungmin Bang, Jung Min Han. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30664-3

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth – Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan and Wen Yi. https://www.nature.com/articles/s41467-019-13601-8

Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway – Yu Liang, Lidan Hou, Linjing Li, Lei Li, Liming Zhu, Yu Wang, Xin Huang, Yichao Hou, Danxi Zhu, Huimin Zou, Yan Gu, Xiaoling Weng, Yingying Wang, Yue Li, Tianqi Wu, Mengfei Yao, Isabelle Gross, Christian Gaiddon, Meng Luo, Jianhua Wang and Xiangjun Meng. https://www.nature.com/articles/s41388-019-1035-8


Cancer Immunometabolism


Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage – Evi Goulielmaki, Anna Ioannidou, Maria Tsekrekou, Kalliopi Stratigi, Ioanna K. Poutakidou, Katerina Gkirtzimanaki, Michalis Aivaliotis, Konstantinos Evangelou, Pantelis Topalis, Janine Altmüller, Vassilis G. Gorgoulis, Georgia Chatzinikolaou and George A. Garinis. https://www.nature.com/articles/s41467-019-13894-9


Miscellaneous


Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism – Sophie Trefely, JoyceLiu, Katharina Huber, Mary T. Doan, Helen Jiang, Jay Singh, Elianavon Krusenstiern, Anna Bostwick, Peining Xu, Juliane G.Bogner-Strauss, Kathryn E. Wellen, Nathaniel W.Snyder. https://www.sciencedirect.com/science/article/pii/S221287781930907X

Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer – Youngtae Jeong, Jessica A. Hellyer, Henning Stehr, Ngoc T. Hoang, Xiaomin Niu, Millie Das, Sukhmani K. Padda, Kavitha Ramchandran, Joel W. Neal, Heather Wakelee and Maximilian Diehn. https://clincancerres.aacrjournals.org/content/26/1/274

The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis – Vassilis Papalazarou, Tong Zhang, Nikki R. Paul, Amelie Juin, Marco Cantini, Oliver D. K. Maddocks, Manuel Salmeron-Sanchez and Laura M. Machesky. https://www.nature.com/articles/s42255-019-0159-z

Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma – Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D. Tap, Nicola Fabbri, Edward Athanasian, Patrick J. Boland, John H. Healey, Michael F. Berger, Marc Ladanyi and Meera Hameed. https://clincancerres.aacrjournals.org/content/26/2/419


Reviews


The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism – Gerta Hoxhaj and Brendan D. Manning. https://www.nature.com/articles/s41568-019-0216-7

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer – Marteinn Thor Snaebjornsson, Sudha Janaki-Raman, Almut Schulze. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30617-5

Targeting Extracellular Nutrient Dependencies of Cancer Cells – Javier Garcia-Bermudez, Robert T Williams, Rohiverth Guarecuco, Kıvanç Birsoy. https://www.sciencedirect.com/science/article/pii/S2212877819309433

The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology – Catherine J. Libby, Jonathan McConathy, Victor Darley-Usmar and Anita B. Hjelmeland. https://cancerres.aacrjournals.org/content/80/1/5

Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer – Kamiya Mehla and Pankaj K. Singh. https://clincancerres.aacrjournals.org/content/26/1/6

Tumor microenvironment differences between primary tumor and brain metastases – Cacho-Díaz B, García-Botello DR, Wegman-Ostrosky T, Reyes-Soto G, Ortiz-Sánchez E, Herrera-Montalvo LA. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-02189-8

Targeting citrate as a novel therapeutic strategy in cancer treatment – Lan Huang, Cindy Wang, Huaxi Xu, Guangyong Peng. https://www.sciencedirect.com/science/article/pii/S0304419X19301593

Dietary patterns and cancer risk – Susan E. Steck and E. Angela Murphy
https://www.nature.com/articles/s41568-019-0227-4

Loads of reviews and primary articles at the special issue in Cancers:
“Metabolic Reprogramming and Vulnerabilities in Cancer” – Guest Editor(s): Deepak Nagrath, Costas Lyssiotis. https://www.mdpi.com/journal/cancers/special_issues/metabolic-reprogram

Including:

Hodakoski, C.; Hopkins, B.D.; Zhang, G.; Su, T.; Cheng, Z.; Morris, R.; Rhee, K.Y.; Goncalves, M.D.; Cantley, L.C. Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.

Sanford-Crane, H.; Abrego, J.; Sherman, M.H. Fibroblasts as Modulators of
Local and Systemic Cancer Metabolism.

Choi, B.-H.; Coloff, J.L. The Diverse Functions of Non-Essential Amino Acids in Cancer.

Combs, J.A.; DeNicola, G.M. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival.

Villa, E.; Ali, E.S.; Sahu, U.; Ben-Sahra, I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.

Bott, A.J.; Maimouni, S.; Zong, W.-X. The Pleiotropic Effects of Glutamine Metabolism in Cancer.

Jiang, J.; Srivastava, S.; Zhang, J. Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Purohit, V.; Simeone, D.M.; Lyssiotis, C.A. Metabolic Regulation of Redox Balance in Cancer.

Petronek, M.S.; Spitz, D.R.; Buettner, G.R.; Allen, B.G. Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism.

Sharma, A.; Boise, L.H.; Shanmugam, M. Cancer Metabolism and the Evasion of
Apoptotic Cell Death.

Weinberg, F.; Ramnath, N.; Nagrath, D. Reactive Oxygen Species in the Tumor
Microenvironment: An Overview.

Cockfield, J.A.; Schafer, Z.T. Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells.

Zhou, W.; Wahl, D.R. Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance.

Guda, M.R.; Labak, C.M.; Omar, S.I.; Asuthkar, S.; Airala, S.; Tuszynski, J.; Tsung, A.J.; Velpula, K.K. GLUT1 and TUBB4 in Glioblastoma Could be Efficacious Targets.

Naffouje, R.; Grover, P.; Yu, H.; Sendilnathan, A.; Wolfe, K.; Majd, N.; Smith, E.P.; Takeuchi, K.; Senda, T.; Kofuji, S.; Sasaki, A.T. Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

Ramteke, P.; Deb, A.; Shepal, V.; Bhat, M.K.
Hyperglycemia Associated Metabolic and Molecular Alterations in Cancer Risk, Progression, Treatment, and Mortality.

Yan, L.; Raj, P.; Yao, W.; Ying, H.
Glucose Metabolism in Pancreatic Cancer.

Haley, J.A.; Ruiz, C.F.; Montal, E.D.; Wang, D.; Haley, J.D.; Girnun, G.D.
Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer.

Loponte, S.; Lovisa, S.; Deem, A.K.; Carugo, A.; Viale, A. The Many Facets of
Tumor Heterogeneity: Is Metabolism Lagging Behind?

Natarajan, S.K.; Venneti, S. Glutamine Metabolism in Brain Tumors. Cancers


Comments / other


A sugary input to leucine sensing – Elyssa Lehman, Robert T. Abraham. https://science.sciencemag.org/content/367/6474/146

How to catch a HIF-the work of Gregg Semenza’s lab on hypoxia-inducible factor 1 – Martin J. Spiering. http://www.jbc.org/content/295/3/715.full.html

Conferences:

Lactate: Unconventional roles of a nutrient along tumor landscape
Organizers: Paola Chiarugi, Pierre Sonveaux, Luigi Ippolito. Florence, Italy, May 08-10 2020. http://meetings.embo.org/event/20-lactate

Cancer Immunometabolism 2020. Rehovot, Israel, May 5-6th.
Organizers: Ayelet Erez and Eyal Gottlieb. http://www.weizmann.ac.il/conferences/CIM2020/

Cancer Metabolism and Signaling 2020. Friday, April 17, 2020, New York.
Organizers: Lydia Finley, Steven Gross, Costas Lyssiotis, Sonya Dougal, Kari Fischer. https://www.nyas.org/events/2020/cancer-metabolism-and-signaling/

MetaboList – December 2019

Special issue of the British Journal of Cancer
Loads of interesting articles and reviews. Edited by Adrian Harris and Christian Frezza
https://www.nature.com/collections/hiciagdefb


Glucose/lactate metabolism


Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells – Pei-Hsuan Chen, Ling Cai Kenneth Huffman, Chendong Yang, Jiyeon Kim, Brandon Faubert, Lindsey Boroughs, Bookyung Ko, Jessica Sudderth, Elizabeth A. McMillan, Luc Girard, Dong Chen, Michael Peyton, Misty D. Shields, Bo Yao, David S. Shames, Hyun Seok Kim, Brenda Timmons, Ikuo Sekine, Rebecca Britt, Stephanie Weber, Lauren A. Byers, John V. Heymach, Jing Chen, Michael A. White, John D. Minna, Guanghua Xiao, Ralph J. DeBerardinis. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30683-5

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer – Alba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G. Zacharias, Thomas P. Mathews, Clary B. Clish, Ralph J. DeBerardinis, Caroline A. Lewis and Matthew G. Vander Heiden. https://www.nature.com/articles/s41467-019-13419-4

KRAS4A directly regulates hexokinase-1 – Caroline R. Amendola, James P. Mahaffey, Seth J. Parker, Ian M. Ahearn, Wei-Ching Chen, Mo Zhou, Helen Court, Jie Shi, Sebastian L. Mendoza, Michael J. Morten, Eli Rothenberg, Eyal Gottlieb, Youssef Z. Wadghiri, Richard Possemato, Stevan R. Hubbard, Allan Balmain, Alec C. Kimmelman and Mark R. Philips. https://www.nature.com/articles/s41586-019-1832-9

A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer – Ke Huang, Qian Liang, Ye Zhou, Lu-lu Jiang, Wei-ming Gu, Ming-yu Luo, Ya-bin Tang, Yang Wang, Wei Lu, Min Huang, Sheng-zhe Zhang, Guang-lei Zhuang, Qing Dai, Qian-cheng Shen, Jian Zhang, Hui-min Lei, Liang Zhu, De-yong Ye, Hong-zhuan Chen, Lu Zhou, Ying Shen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30517-0

Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis – Jinlu Dai, June Escara-Wilke, Jill M. Keller, Younghun Jung, Russell S. Taichman, Kenneth J. Pienta and Evan T. Keller. https://rupress.org/jem/article-abstract/216/12/2883/132527

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect – Aoxing Cheng, Peng Zhang, Bo Wang, Dongdong Yang, Xiaotao Duan, Yongliang Jiang, Tian Xu, Ya Jiang, Jiahui Shi, Chengtao Ding, Gao Wu, Zhihong Sang, Qiang Wu, Hua Wang, Mian Wu, Zhiyong Zhang, Xin Pan, Yue-yin Pan, Ping Gao, Huafeng Zhang, Cong-zhao Zhou, Jing Guo and Zhenye Yang. https://www.nature.com/articles/s41467-019-13485-8

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner – Reika Shiratori, Kenta Furuichi, Masashi Yamaguchi, Natsumi Miyazaki, Haruna Aoki, Hiroji Chibana, Kousei Ito and Shigeki Aoki. https://www.nature.com/articles/s41598-019-55296-3

The TGFβ1-FOXM1-HMGA1-TGFβ1 positive feedback loop increases the cisplatin resistance of non-small cell lung cancer by inducing G6PD expression – Zhang R, Tao F, Ruan S, Hu M, Hu Y, Fang Z, Mei L, Gong C. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895501/

Does Tumor FDG-PET-Avidity Represent Enhanced Glycolytic Metabolism in Non-Small Cell Lung Cancer? – Kernstine KH, Faubert B, Do QN, Rogers TJ, Hensley CT, Cai L, Torrealba J, Oliver D, Waschmann JW, Lenkinski RE, Malloy CR, Deberardinis RJ. https://www.annalsthoracicsurgery.org/article/S0003-4975(19)31875-2/abstract

Decreased FBP1 expression rewires metabolic processes affecting aggressiveness of glioblastoma – Beomseok Son, Sungmin Lee, Hyunwoo Kim, Hyunkoo Kang, Jaewan Jeon, Sunmi Jo, Ki Moon Seong, Su-Jae Lee, HyeSook Youn and BuHyun Youn. https://www.nature.com/articles/s41388-019-0974-4

Metabolic heterogeneity confers differences in melanoma metastatic potential – Alpaslan Tasdogan, Brandon Faubert, Vijayashree Ramesh, Jessalyn M. Ubellacker, Bo Shen, Ashley Solmonson, Malea M. Murphy, Zhimin Gu, Wen Gu, Misty Martin, Stacy Y. Kasitinon, Travis Vandergriff, Thomas P. Mathews, Zhiyu Zhao, Dirk Schadendorf, Ralph J. DeBerardinis and Sean J. Morrison. https://www.nature.com/articles/s41586-019-1847-2


Amino acids


Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis – Craig Ramirez, Andrew D. Hauser, Emily A. Vucic and Dafna Bar-Sagi. https://www.nature.com/articles/s41586-019-1831-x

A Covalent Small Molecule Inhibitor of Glutamate-Oxaloacetate Transaminase 1 Impairs Pancreatic Cancer Growth – Tomohiro Yoshida, Shingo Yamasaki, Osamu Kaneko, Naofumi Taoka, Yusuke Tomimoto, Ichiji Namatame, Toshiko Yahata, Sadao Kuromitsu, Lewis C Cantley, Costas A Lyssiotis. https://www.sciencedirect.com/science/article/pii/S0006291X19322582

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis – Kai Su Greene, Michael J. Lukey, Xueying Wang, Bryant Blank, Joseph E. Druso, Miao-chong J. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira Negrón Abril, Jon W. Erickson, Kristin F. Wilson, Hening Lin, Robert S. Weiss and Richard A. Cerione. https://www.pnas.org/content/116/52/26625.abstract?etoc


Lipid metabolism


ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma – Beibei Liang, Rui Chen, Shaohua Song, Hao Wang, Guowei Sun, Hao Yang, Wei Jing, Xuyu Zhou, Zhiren Fu, Gang Huang and Jian Zhao. https://www.nature.com/articles/s41419-019-2054-7

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies – William W. Feng, Owen Wilkins, Scott Bang, Matthew Ung, Jiaqi Li, Jennifer An, Carmen del Genio, Kaleigh Canfield, James DiRenzo, Wendy Wells, Arti Gaur, R. Brooks Robey, Jessie Yanxiang Guo, Ryan L. Powles, Christos Sotiriou, Lajos Pusztai, Maria Febbraio, Chao Cheng, William B. Kinlaw, Manabu Kurokawa. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31479-2

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity – Yurena Vivas-García, Paola Falletta, Jana Liebing, Pakavarin Louphrasitthiphol, Yongmei Feng, Jagat Chauhan, David A. Scott, Nicole Glodde, Ana Chocarro-Calvo, Sarah Bonham, Andrei L. Osterman, Roman Fischer, Ze’ev Ronai, Custodia García-Jiménez, Michael Hölzel, Colin R. Goding. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30792-0

Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis – Yahui Zhu, Li Gu, Xi Lin, Cheng Liu, Bingjun Lu, Kaisa Cui, Feng Zhou, Qiu Zhao, Edward V. Prochownik, Chengpeng Fan, Youjun Li. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30793-2


Nucleotides


Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid – Aneta Jurkiewicz, Ewa Leśniewska, Małgorzata Cieśla, Neuton Gorjão, Theodoros Kantidakis, Robert J. White, Magdalena Boguta and Damian Graczyk. http://mcb.asm.org/content/40/1/e00294-19.abstract?etoc

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy – David A. Schaer, Sandaruwan Geeganage, Nelusha Amaladas, Zhao Hai Lu, Erik R. Rasmussen, Andreas Sonyi, Darin Chin, Andrew Capen, Yanxia Li, Catalina M. Meyer, Bonita D. Jones, Xiaodong Huang, Shuang Luo, Carmine Carpenito, Kenneth D. Roth, Alexander Nikolayev, Bo Tan, Manisha Brahmachary, Krishna Chodavarapu, Frank C. Dorsey, Jason R. Manro, Thompson N. Doman, Gregory P. Donoho, David Surguladze, Gerald E. Hall, Michael Kalos and Ruslan D. Novosiadly. https://clincancerres-aacrjournals-org.sire.ub.edu/content/25/23/7175

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis – Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie. https://elifesciences.org/articles/52135


Mitochondria


BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents – Arun Kanakkanthara, Kiran Kurmi, Thomas L. Ekstrom, Xiaonan Hou, Emma R. Purfeerst, Ethan P. Heinzen, Cristina Correia, Catherine J. Huntoon, Daniel O’Brien, Andrea E. Wahner Hendrickson, Sean C. Dowdy, Hu Li, Ann L. Oberg, Taro Hitosugi, Scott H. Kaufmann, S. John Weroha and Larry M. Karnitz. https://cancerres.aacrjournals.org/content/79/23/5920

Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate – Schoonjans CA, Joudiou N, Brusa D, Corbet C, Feron O, Gallez B. https://www.sciencedirect.com/science/article/abs/pii/S0304383519306056

The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis – Shiran Rabinovich, Alon Silberman, Lital Adler, Shani Agron, Smadar Levin-Zaidman, Amir Bahat, Ziv Porat, Efrat Ben-Zeev, Inbal Geva, Maxim Itkin, Sergey Malitsky, Adam Buchaklian, Daniel Helbling, David Dimmock and Ayelet Erez. https://www.nature.com/articles/s41388-019-0976-2


Metformin


Combination of Metformin and Gefitinib as First-Line Therapy for Nondiabetic Advanced NSCLC Patients with EGFR Mutations: A Randomized, Double-Blind Phase II Trial – Li Li, Liyan Jiang, Yubo Wang, Yizhuo Zhao, Xiao-Ju Zhang, Guoming Wu, Xiangdong Zhou, Jianguo Sun, Jun Bai, Biyong Ren, Kun Tian, Zhi Xu, Hua-liang Xiao, Qi Zhou, Rui Han, Hengyi Chen, Haidong Wang, Zhenzhou Yang, Chan Gao, Shangli Cai and Yong He. https://clincancerres.aacrjournals.org/content/25/23/6967

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss – Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Pedrum Mohammadi-Shemirani, Marisa R. Morrow, Robert M. Gutgesell, Rachel Lu, Amogelang R. Raphenya, Mostafa Kabiri, Andrew G. McArthur, Natalia McInnes, Sibylle Hess, Guillaume Paré, Hertzel C. Gerstein and Gregory R. Steinberg. https://www.nature.com/articles/s42255-019-0146-4

Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk – Peter C. Hart, Hilary A. Kenny, Niklas Grassl, Karen M. Watters, Lacey M. Litchfield, Fabian Coscia, Ivana Blaženović, Lisa Ploetzky, Oliver Fiehn, Matthias Mann, Ernst Lengyel, Iris L. Romero. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31570-0

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin – Sivalingam VN, Latif A, Kitson S, McVey R, Finegan KG, Marshall K, Lisanti MP, Sotgia F, Stratford IJ, Crosbie EJ. https://www.nature.com/articles/s41416-019-0627-y

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes – Hamidullah Khan, Ashish Anshu, Aman Prasad, Sushmita Roy, Justin Jeffery, Wasakorn Kittipongdaja, David T. Yang, Stefan M. Schieke. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31478-0

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks – Benjamin D. Stein, Diego Calzolari, Kristina Hellberg, Ying S. Hu, Lin He, Chien-Min Hung, Erin Q. Toyama, Debbie S. Ross, Björn F. Lillemeier, Lewis C. Cantley, John R. Yates III, Reuben J. Shaw. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31450-0


Starvation / AMPK


AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation – Jianhui Li, Michal Breker, Morven Graham, Maya Schuldiner, Mark Hochstrasser. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008387

TFEB controls retromer expression in response to nutrient availability – Rachel Curnock, Alessia Calcagni, Andrea Ballabio, Peter J. Cullen. http://jcb.rupress.org/content/218/12/3954?etoc

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress – Zhiyuan You, Wen-Xue Jiang, Ling-Yun Qin, Zhou Gong, Wei Wan, Jin Li, Yusha Wang, Hongtao Zhang, Chao Peng, Tianhua Zhou, Chun Tang and Wei Liu. https://www.nature.com/articles/s41467-019-13718-w

TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2α-ATF4 pathway – Su-Jin Jeon, Jun-Ho Ahn, Debasish Halder, Hyun-Soo Cho, Jung-Hwa Lim, Soo Young Jun, Jeong-Ju Lee, Ji-Yong Yoon, Min-Hyuk Choi, Cho-Rok Jung, Jin-Man Kim and Nam-Soon Kim. https://www.nature.com/articles/s41419-019-2190-0

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A – Xue Gao, Liang Zhao, Shuangping Liu, Yuancheng Li, Siyuan Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J. Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang Shan, Jing Chen. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30692-6


Hypoxia and HIF


KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis – Xu Qian, Xinjian Li, Zhumei Shi, Xiaoming Bai, Yan Xia, Yanhua Zheng, Daqian Xu, Feng Chen, Yongping You, Jing Fang, Zhibin Hu, Qin Zhou, Zhimin Lu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30724-5

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells – Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga and Jan Jacob Schuringa. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0206-y

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils – Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A. Lowell and Adrian Erlebacher. https://www.jci.org/articles/view/130952


Miscellaneous


PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control – Lorea Valcarcel-Jimenez, Alice Macchia, Eva Crosas-Molist, Ariane Schaub-Clerigué, Laura Camacho, Natalia Martín-Martín, Paolo Cicogna, Cristina Viera-Bardón, Sonia Fernández-Ruiz, Irene Rodriguez-Hernandez, Ivana Hermanova, Ianire Astobiza, Ana R. Cortazar, Jon Corres-Mendizabal, Antonio Gomez-Muñoz, Victoria Sanz-Moreno, Verónica Torrano and Arkaitz Carracedo. https://cancerres.aacrjournals.org/content/79/24/6153

SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia – Ali R. Nasiri, Marcos R. Rodrigues, Zongyu Li, Brooks P. Leitner and Rachel J. Perry. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0203-1

Cerebrospinal fluid-based metabolomics to characterize different types of brain tumors – Wang FX, Chen K, Huang FQ, Alolga RN, Ma J, Wu ZX, Fan Y, Ma G, Guan M. https://link.springer.com/article/10.1007%2Fs00415-019-09665-7

Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer – Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. https://www.nature.com/articles/s41598-019-55952-8

A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines – Sheree D. Martin and Sean L. McGee. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0207-x


Reviews / comments


Mitochondrial TCA cycle metabolites control physiology and disease – Inmaculada Martínez-Reyes and Navdeep S. Chandel. https://www.nature.com/articles/s41467-019-13668-3

A Tumor Agnostic Therapeutic Strategy for Hexokinase 1–Null/Hexokinase 2–Positive Cancers – Shili Xu and Harvey R. Herschman. https://cancerres.aacrjournals.org/content/79/23/5907

The Metabolic Interplay between Cancer and Other Diseases – Anne Le, Sunag Udupa, Cissy Zhang. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30219-5

Metabolic Regulation of Macrophage Polarization in Cancer – Kamiya Mehla, Pankaj K. Singh. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30200-6

Sweet Temptation: From Sugar Metabolism to Gene Regulation – Giulia Notarangelo, Marcia C. Haigis. https://www.cell.com/immunity/fulltext/S1074-7613(19)30489-3

The Mitochondrion as an Emerging Therapeutic Target in Cancer – Katherine G. Roth, Isa Mambetsariev, Prakash Kulkarni, Ravi Salgia. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30171-6

The impact of oncogenic RAS on redox balance and implications for cancer development – Jonathan K. M. Lim and Gabriel Leprivier. https://www.nature.com/articles/s41419-019-2192-y

Glutamine Skipping the Q into Mitochondria – Zachary E. Stine, Chi V. Dang. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30295-3

MetaboList – November 2019


Glucose metabolism


Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis – Peiwei Huangyang, Fuming Li, Pearl Lee, Itzhak Nissim, Aalim M. Weljie, Anthony Mancuso, Bo Li, Brian Keith, Sam S. Yoon, M. Celeste Simon. https://www.sciencedirect.com/science/article/abs/pii/S1550413119305686

Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers – Ramon C. Sun, Vikas V. Dukhande, Zhengqiu Zhou, Lyndsay E.A. Young, Shane Emanuelle, Christine Fillmore Brainson, Matthew S. Gentry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30443-7

An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma – Chen-Lei Wen, Ke Huang, Lu-Lu Jiang, Xiong-Xiong Lu, Yu-Ting Dai, Min-Min Shi, Xiao-Mei Tang, Qing-Bing Wang, Xiao-Dan Zhang, Peng-Hui Wang, Hui-Ti Li, Xiao-Xue Ruan, Li-Wen Wang, Xin-Jing Wang, Qian Wang, Wei Lu, Xiao-Qiang Xiang, Xun Sun, Yan-Hui Xu, Lu-Hua Lai, Qian Zhan, Hong-Wei Li, Cheng-Hong Peng, Jing Chen, Jin-Yan Huang, De-Yong Ye, Sai-Juan Chen, Zhu Chen, Min Li, Yuan Fang, Bai-Yong Shen, and Lu Zhou. https://www.pnas.org/content/116/46/23264.abstract?etoc

PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1 – Xu Qian, Xinjian Li, Zhumei Shi, Yan Xia, Qingsong Cai, Daqian Xu, Lin Tan, Linyong Du, Yanhua Zheng, Dan Zhao, Chuanbao Zhang, Philip L. Lorenzi, Yongping You, Bing-Hua Jiang, Tao Jiang, Haitao Li, Zhimin Lu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30622-7

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis – Maria V. Liberti, Annamarie E. Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R. Singleton, Zufeng Guo, Jun O. Liu, Kris C. Wood and Jason W. Locasale. http://www.jbc.org/content/early/2019/11/20/jbc.RA119.010903.abstract


Lactate


Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts – Tushar D Bhagat, Dagny Von Ahrens, Meelad Dawlaty, Yiyu Zou, Joelle Baddour, Abhinav Achreja, Hongyun Zhao, Lifeng Yang, Brijesh Patel, Changsoo Kwak, Gaurav S Choudhary, Shanisha Gordon-Mitchell, Srinivas Aluri, Sanchari Bhattacharyya, Srabani Sahu, Yiting Yu, Matthias Bartenstein, Orsi Giricz, Masako Suzuki, Davendra Sohal, Sonal Gupta, Paola A Guerrero, Surinder Batra, Michael Goggins, Ulrich Steidl, John Greally, Beamon Agarwal, Kith Pradhan, Debabrata Banerjee, Deepak Nagrath, Anirban Maitra, Amit Verma. https://elifesciences.org/articles/50663

Lactic Acidosis Promotes Mitochondrial Biogenesis in Lung Adenocarcinoma Cells, Supporting Proliferation Under Normoxia or Survival Under Hypoxia – Romero-Garcia S, Prado-Garcia H, Valencia-Camargo AD, Alvarez-Pulido A. https://www.frontiersin.org/articles/10.3389/fonc.2019.01053/full

Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments – Yasna Contreras-Baeza, Pamela Y. Sandoval, Romina Alarcón, Alex Galaz, Francisca Cortés-Molina, Karin Alegría, Felipe Baeza-Lehnert, Robinson Arce-Molina, Anita Guequén, Carlos A Flores, Alejandro San Martín and L. Felipe Barros. http://www.jbc.org/content/early/2019/11/12/jbc.RA119.009093.1.abstract


Cystine / Glutathione


Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion – Mahsa Zarei, Heng Du, Amin H. Nassar, Rachel E. Yan, Krinio Giannikou, Sneha H. Johnson, Hilaire C. Lam, Elizabeth P. Henske, Yubao Wang, Tinghu Zhang, John Asara and David J. Kwiatkowski. http://jem.rupress.org/content/216/11/2635?etoc

Oncogenic KRAS Sensitizes Lung Adenocarcinoma to GSK-J4–Induced Metabolic and Oxidative Stress – Beom-Jin Hong, Woo-Yong Park, Hwa-Ryeon Kim, Jin Woo Moon, Ho Yeon Lee, Jun Hyung Park, Seon-Kyu Kim, Youngbin Oh, Jae-Seok Roe and Mi-Young Kim. https://cancerres.aacrjournals.org/content/79/22/5849


Glutamine


Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion – Robert D. Leone, Liang Zhao, Judson M. Englert, Im-Meng Sun, Min-Hee Oh, Im-Hong Sun, Matthew L. Arwood, Ian A. Bettencourt, Chirag H. Patel, Jiayu Wen, Ada Tam, Richard L. Blosser, Eva Prchalova, Jesse Alt, Rana Rais, Barbara S. Slusher, Jonathan D. Powell. https://science.sciencemag.org/content/366/6468/1013

CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth – Victoria M.-Y. Wang, Rute M. M. Ferreira, Jorge Almagro, Theodore Evan, Nathalie Legrave, May Zaw Thin, David Frith, Joana Carvalho, David J. Barry, Ambrosius P. Snijders, Eleanor Herbert, Emma L. Nye, James I. MacRae and Axel Behrens. https://www.nature.com/articles/s41556-019-0407-1


Lipid metabolism


Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells – Maria J. Bueno, Veronica Jimenez-Renard, Sara Samino, Jordi Capellades, Alejandra Junza, María Luz López-Rodríguez, Javier Garcia-Carceles, Irene Lopez-Fabuel, Juan P. Bolaños, Navdeep S. Chandel, Oscar Yanes, Ramon Colomer and Miguel Quintela-Fandino. https://www.nature.com/articles/s41467-019-13028-1

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors – Andrea Aloia, Daniela Müllhaupt, Christophe D. Chabbert, Tanja Eberhart, Stefanie Flückiger-Mangual, Ana Vukolic, Ossia Eichhoff, Anja Irmisch, Leila T. Alexander, Ernesto Scibona, Dennie T. Frederick, Benchun Miao, Tian Tian, Chaoran Cheng, Lawrence N. Kwong, Zhi Wei, Ryan J. Sullivan, Genevieve M. Boland, Meenhard Herlyn, Keith T. Flaherty, Nicola Zamboni, Reinhard Dummer, Gao Zhang, Mitchell P. Levesque, Wilhelm Krek and Werner J. Kovacs. https://clincancerres.aacrjournals.org/content/25/22/6852


Nucleotides


Identification of DHODH as a therapeutic target in small cell lung cancer – Leanne Li , Sheng Rong Ng, Caterina I. Colón, Benjamin J. Drapkin, Peggy P. Hsu, Zhaoqi Li, Christopher S. Nabel, Caroline A. Lewis, Rodrigo Romero, Kim L. Mercer, Arjun Bhutkar, Sarah Phat, David T. Myers, Mandar Deepak Muzumdar, Peter M. K. Westcott, Mary Clare Beytagh, Anna F. Farago, Matthew G. Vander Heiden, Nicholas J. Dyson, Tyler Jacks. https://stm.sciencemag.org/content/11/517/eaaw7852

Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression – Parmanand Malvi, Radoslav Janostiak, Arvindhan Nagarajan, Guoping Cai, Narendra Wajapeyee. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008439

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance – Simona Dalin, Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss, Helen S. Mueller, Emanuel Kreidl, Silvia Fenoglio, Alba Luengo, Jacqueline A. Lees, Matthew G. Vander Heiden, Douglas A. Lauffenburger and Michael T. Hemann. https://cancerres.aacrjournals.org/content/79/22/5723


Mitochondria


Lipid signalling drives proteolytic rewiring of mitochondria by YME1L – Thomas MacVicar, Yohsuke Ohba, Hendrik Nolte, Fiona Carola Mayer, Takashi Tatsuta, Hans-Georg Sprenger, Barbara Lindner, Yue Zhao, Jiahui Li, Christiane Bruns, Marcus Krüger, Markus Habich, Jan Riemer, Robin Schwarzer, Manolis Pasparakis, Sinika Henschke, Jens C. Brüning, Nicola Zamboni and Thomas Langer. https://www.nature.com/articles/s41586-019-1738-6

Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate – Rachel J. Hunt,  Lucy Granat, Gregory S. McElroy, Ramya Ranganathan, Navdeep S. Chandel, Joseph M. Bateman. http://jcb.rupress.org/content/early/2019/10/29/jcb.201904148

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange – Atsushi Hoshino, Wei-jia Wang, Shogo Wada, Chris McDermott-Roe, Chantell S. Evans, Bridget Gosis, Michael P. Morley, Komal S. Rathi, Jian Li, Kristina Li, Steven Yang, Meagan J. McManus, Caitlyn Bowman, Prasanth Potluri, Michael Levin, Scott Damrauer, Douglas C. Wallace, Erika L. F. Holzbaur and Zoltan Arany. https://www.nature.com/articles/s41586-019-1667-4

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent – Dane M Wolf, Mayuko Segawa, Arun Kumar Kondadi, Ruchika Anand, Sean T Bailey, Andreas S Reichert, Alexander M van der Bliek, David B Shackelford, Marc Liesa, Orian S Shirihai. https://www.embopress.org/doi/full/10.15252/embj.2018101056

Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma – I-Che Chung, Lih-Chyang Chen, Ngan-Ming Tsang, Wen-Yu Chuang, Tzu-Chieh Liao, Sheng-Ning Yuan, Chun-Nan OuYang, David M Ojcius, Chih-Ching Wu, Yu-Sun Chang. https://www.mcponline.org/content/early/2019/11/13/mcp.RA119.001808.long

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering – Tsz-Leung To, Alejandro M. Cuadros, Hardik Shah, Wendy H.W. Hung, Yang Li, Sharon H. Kim, Daniel H.F. Rubin, Ryan H. Boe, Sneha Rath, John K. Eaton, Federica Piccioni, Amy Goodale, Zohra Kalani, John G. Doench, David E. Root, Stuart L. Schreiber, Scott B. Vafai, Vamsi K. Mootha. https://www.cell.com/cell/fulltext/S0092-8674(19)31182-1


Starvation


Lipid signalling drives proteolytic rewiring of mitochondria by YME1L – Thomas MacVicar, Yohsuke Ohba, Hendrik Nolte, Fiona Carola Mayer, Takashi Tatsuta, Hans-Georg Sprenger, Barbara Lindner, Yue Zhao, Jiahui Li, Christiane Bruns, Marcus Krüger, Markus Habich, Jan Riemer, Robin Schwarzer, Manolis Pasparakis, Sinika Henschke, Jens C. Brüning, Nicola Zamboni and Thomas Langer. https://www.nature.com/articles/s41586-019-1738-6

A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer – Stefanie Schmidt, David Gay, Friedrich Wilhelm Uthe, Sarah Denk, Madelon Paauwe, Niels Matthes, Markus Elmar Diefenbacher, Sheila Bryson, Fiona Clare Warrander, Florian Erhard, Carsten Patrick Ade, Apoorva Baluapuri, Susanne Walz, Rene Jackstadt, Catriona Ford, Georgios Vlachogiannis, Nicola Valeri, Christoph Otto, Christina Schülein-Völk, Katja Maurus, Werner Schmitz, John Raymond Philip Knight, Elmar Wolf, Douglas Strathdee, Almut Schulze, Christoph-Thomas Germer, Andreas Rosenwald, Owen James Sansom, Martin Eilers and Armin Wiegering. https://www.nature.com/articles/s41556-019-0408-0

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells – Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron. https://elifesciences.org/articles/50149


Asparagine restriction


SLC1A3 contributes to L‐asparaginase resistance in solid tumors – Jianhui Sun, Remco Nagel, Esther A Zaal, Alejandro Piñeiro Ugalde, Ruiqi Han, Natalie Proost, Ji‐Ying Song, Abhijeet Pataskar, Artur Burylo, Haigen Fu, Gerrit J Poelarends, Marieke van de Ven, Olaf van Tellingen, Celia R Berkers, Reuven Agami. https://www.embopress.org/doi/full/10.15252/embj.2019102147

Translational reprogramming marks adaptation to asparagine restriction in cancer – Gaurav Pathria, Joo Sang Lee, Erez Hasnis, Kristofferson Tandoc, David A. Scott, Sachin Verma, Yongmei Feng, Lionel Larue, Avinash D. Sahu, Ivan Topisirovic, Eytan Ruppin and Ze’ev A. Ronai. https://www-nature-com.sire.ub.edu/articles/s41556-019-0415-1


mTOR / AMPK


Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids – Maria A. Frias, Suman Mukhopadhyay, Elyssa Lehman, Aleksandra Walasek, Matthew Utter, Deepak Menon and David A. Foster. http://www.jbc.org/content/early/2019/11/24/jbc.RA119.010892.abstract

Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase – Kuo-Hui Su, Siyuan Dai, Zijian Tang, Meng Xu, Chengkai Dai. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30660-4

Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells – Chenran Wang, Michael A. Haas, Fuchun Yang, Syn Yeo, Takako Okamoto, Song Chen, Jian Wen, Pranjal Sarma, David R. Plas and Jun-Lin Guan. https://www.nature.com/articles/s42255-019-0137-5


Hypoxia


Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI – Victoria Lauer, Steffen Grampp, James Platt, Veronique Lafleur, Olivia Lombardi, Hani Choudhry, Franziska Kranz, Arndt Hartmann, Bernd Wullich, Atsushi Yamamoto, Mathew L Coleman, Peter J Ratcliffe, David R Mole and Johannes Schödel. http://www.jbc.org/content/early/2019/11/05/jbc.RA119.009827.abstract

Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth – Marco Maruggi, Fabiana Izidro Layng, Robert Lemos Jr, Guillermina Garcia, Brian P. James, Monica Sevilla, Ferran Soldevilla, Bas J. Baaten, Petrus R. de Jong, Mei Yee Koh and Garth Powis. https://cancerres.aacrjournals.org/content/79/22/5839


Cancer Immunometabolism


Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring – Valentina Pucino, Michelangelo Certo, Vinay Bulusu, Danilo Cucchi, Katriona Goldmann, Elena Pontarini, Robert Haas, Joanne Smith, Sarah E. Headland, Kevin Blighe, Massimiliano Ruscica, Frances Humby, Myles J. Lewis, Jurre J. Kamphorst, Michele Bombardieri, Costantino Pitzalis, Claudio Mauro. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30559-5

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor – Jing-Yiing Wu, Tsai-Wang Huang, Yi-Ting Hsieh, Yi-Fu Wang, Chia-Chien Yen, Guan-Lin Lee, Chang-Ching Yeh, Yi-Jen Peng, Ya-Yi Kuo, Hsiu-Ting Wen, Hui-Chen Lin, Cheng-Wen Hsiao, Kenneth K. Wu, Hsing-Jien Kung, Yu-Juei Hsu, Cheng-Chin Kuo. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30801-9

Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling – Koen A. Marijt, Marjolein Sluijter, Laura Blijleven, Sofie H. Tolmeijer, Ferenc A. Scheeren, Sjoerd H. van der Burg and Thorbald van Hall. https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0627-8

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth – Zhang C, Yue C, Herrmann A, Song J, Egelston C, Wang T, Zhang Z, Li W, Lee H, Aftabizadeh M, Li YJ, Lee PP, Forman S, Somlo G, Chu P, Kruper L, Mortimer J, Hoon DSB, Huang W, Priceman S, Yu H. https://www.sciencedirect.com/science/article/abs/pii/S1550413119306047


Metformin


Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK – Yu Wang, Hongying An, Ting Liu, Caolitao Qin, Hiromi Sesaki, Shaodong Guo, Sally Radovick, Mehboob Hussain, Akhil Maheshwari, Fredric E. Wondisford, Brian O’Rourke, Ling He. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31267-7

Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma – Ram C. Shankaraiah, Elisa Callegari, Paola Guerriero, Alessandro Rimessi, Paolo Pinton, Laura Gramantieri, Enrico M. Silini, Silvia Sabbioni and Massimo Negrini. https://www.nature.com/articles/s41388-019-0942-z


Miscellaneous


eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma – Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco Jr., Michael Pollak, Ola Larsson, Jerry Pelletier and Iok In Christine Chio. https://www.nature.com/articles/s41467-019-13086-5

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells – Eric H. Ma, Mark J. Verway, Radia M. Johnson, Dominic G. Roy, Mya Steadman, Sebastian Hayes, Kelsey S. Williams, Ryan D. Sheldon, Bozena Samborska, Penelope A. Kosinski, Hyeryun Kim, Takla Griss, Brandon Faubert, Stephanie A. Condotta, Connie M. Krawczyk, Ralph J. DeBerardinis, Kelly M. Stewart, Martin J. Richer, Victor Chubukov, Thomas P. Roddy, Russell G. Jones. https://www.cell.com/immunity/fulltext/S1074-7613(19)30374-7

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism – Sophie Trefely, Joyce Liu, Katharina Huber, Mary T. Doan, Helen Jiang, Jay Singh, Elianavon Krusenstiern, Anna Bostwick, Peining Xu, Juliane G. Bogner-Strauss, Kathryn E. Wellen, Nathaniel W.Snyder. https://www.sciencedirect.com/science/article/pii/S221287781930907X


Reviews


Nutrient regulation of mTORC1 at a glance – Kendall J. Condon and David M. Sabatini. http://jcs.biologists.org/content/132/21/jcs222570?etoc

Metabolism in the Tumor Microenvironment – Allison N. Lau and Matthew G. Vander Heiden. https://www.annualreviews.org/doi/abs/10.1146/annurev-cancerbio-030419-033333

Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment – Barrie Peck, Almut Schulze. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30190-6

Targeting cellular cholesterol for anticancer therapy – Liang Gu, Sourav Taru Saha, Jodie Thomas, Mandeep Kaur. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15018

DUBs, Hypoxia, and Cancer – Daniela Mennerich, Kateryna Kubaichuk, Thomas Kietzmann. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30182-7

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches – de la Cruz-López KG, Castro-Muñoz LJ, Reyes-Hernández DO, García-Carrancá A, Manzo-Merino J. https://www.frontiersin.org/articles/10.3389/fonc.2019.01143/full

New insights into transcriptional reprogramming during cellular stress – Samu V. Himanen, Lea Sistonen. https://jcs.biologists.org/content/132/21/jcs238402?etoc

Tracking intra‐ and inter‐organelle signaling of mitochondria – Corina T. Madreiter‐Sokolowski, Jeta Ramadani‐Muja, Gabriela Ziomek, Sandra Burgstaller, Helmut Bischof, Zhanat Koshenov, Benjamin Gottschalk, Roland Malli, Wolfgang F. Graier. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15103

Modular biogenesis of mitochondrial respiratory complexes – Mario H. Barrosa, Gavin P. McStay. https://www.sciencedirect.com/science/article/pii/S1567724919301394


Comments


Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer – Christopher J. Halbrook, Daniel R. Wahl, Costas A. Lyssiotis. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30208-7

Metabolic vulnerability in tumours illuminated – Aparna D. Rao, Ralph J. DeBerardinis. https://www.nature.com/articles/d41586-019-03239-3

The Transsulfuration Pathway Makes, the Tumor Takes – Ross Weber, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30565-

Metabolic Stress Triggers Immune Escape by Tumors – Joana B. Nunes, Bart Everts. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30184-0

Mitochondrial cristae as insulated transformers of metabolic energy – Michael Schlame. https://www.embopress.org/doi/abs/10.15252/embj.2019103472

Metabolic adaption through regulated proteolysis – Wei Wong. https://stke.sciencemag.org/content/12/608/eaba2257

T Cell Metabolism in a State of Flux – Siva Karthik Varanasi, Shixin Ma, Susan M. Kaech. https://www.cell.com/immunity/fulltext/S1074-7613(19)30456-X

Extra: Christian Frezza’s selections

http://biomed.news/bims-camemi/2019-11-10

http://biomed.news/bims-camemi/2019-11-17

http://biomed.news/bims-camemi/2019-11-24

http://biomed.news/bims-camemi/2019-12-01

MetaboList – October 2019


mTOR


Structural basis for the docking of mTORC1 on the lysosomal surface – Kacper B. Rogala, Xin Gu, Jibril F. Kedir, Monther Abu-Remaileh, Laura F. Bianchi, Alexia M. S. Bottino, Rikke Dueholm, Anna Niehaus, Daan Overwijn, Ange-Célia Priso Fils, Sherry X. Zhou, Daniel Leary, Nouf N. Laqtom, Edward J. Brignole, David M. Sabatini. https://science.sciencemag.org/content/366/6464/468

Architecture of human Rag GTPase heterodimers and their complex with mTORC1 – Madhanagopal Anandapadamanaban, Glenn R. Masson, Olga Perisic, Alex Berndt, Jonathan Kaufman, Chris M. Johnson, Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Roger L. Williams. https://science.sciencemag.org/content/366/6462/203

mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux – Florian Beaumatin, Jim O’Prey, Valentin J.A. Barthet, Barbara Zunino, Jean-Philippe Parvy, Alexis Maximilien Bachmann, Margaret O’Prey, Elżbieta Kania, Pablo Sierra Gonzalez, Robin Macintosh, Laurence Y. Lao, Colin Nixon, Jonathan Lopez, Jaclyn S. Long, Stephen W.G. Tait, Kevin M. Ryan. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30551-9

Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1 – Eugènia Almacellas, Joffrey Pelletier, Anna Manzano, Antonio Gentilella, Santiago Ambrosio, Caroline Mauvezin, Albert Tauler. https://www.cell.com/iscience/fulltext/S2589-0042(19)30379-7

Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment – Brittany Angarola and Shawn M. Ferguson. https://www.molbiolcell.org/doi/10.1091/mbc.E19-03-0146?ai=s5&ui=2oy6&af=T

The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast – Sophie Reidman, Adiel Cohen, Martin Kupiec and Ronit Weisman. http://www.jbc.org/content/early/2019/10/22/jbc.RA119.010101.abstract

CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival – Laia Martínez-Carreres, Julien Puyal, Lucía C. Leal-Esteban, Meritxell Orpinell, Judit Castillo-Armengol, Albert Giralt, Oleksandr Dergai, Catherine Moret, Valentin Barquissau, Anita Nasrallah, Angélique Pabois, Lianjun Zhang, Pedro Romero, Isabel C. Lopez-Mejia and Lluis Fajas. https://cancerres.aacrjournals.org/content/79/20/5245


Starvation / nutrient sensing


α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development – Xiongjun Wang, Ruilong Liu, Xiujuan Qu, Hua Yu, Huiying Chu, Yajuan Zhang, Wencheng Zhu, Xueyuan Wu, Hong Gao, Bangbao Tao, Wenfeng Li, Ji Liang, Guohui Li, Weiwei Yang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30537-4

Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast – Fan Zheng, Bowen Jia, Fenfen Dong, Ling Liu, Faiz Rasul, Jiajia He and Chuanhai Fu. http://www.jbc.org/content/early/2019/09/27/jbc.RA119.010185.abstract

Phosphorylation of Arabidopsis eIF4E and eIFiso4E by SnRK1 inhibits translation – Aaron N. Bruns, Sizhun Li, Gireesha Mohannath, David M. Bisaro. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14935

ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing – Roland Imle, Bei-Tzu Wang, Nicolas Stützenberger, Jana Birkenhagen, Amol Tandon, Matthias Carl, Nastassja Himmelreich, Christian Thiel, Hermann-Josef Gröne, Gernot Poschet, Mirko Völkers, Karsten Gülow, Anne Schröder, Sara Carillo, Stefan Mittermayr, Jonathan Bones, Marcin Mikołaj Kamiński, Stefan Kölker and Sven Wolfgang Sauer. https://www.nature.com/articles/s41598-019-50566-6

The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing – Travis B. Lear, Karina C. Lockwood, Yurong Ouyang, John W. Evankovich, Mads B. Larsen, Bo Lin, Yuan Liu and Bill B. Chen. http://www.jbc.org/content/early/2019/10/04/jbc.AC119.010671.abstract


AMPK


Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells – Karin Bartel, Rolf Müller and Karin von Schwarzenberg. http://www.jbc.org/content/early/2019/10/11/jbc.RA119.010243.abstract

The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC – Pablo E. Hollstein, Lillian J. Eichner, Sonja N. Brun, Anwesh Kamireddy, Robert U. Svensson, Liliana I. Vera, Debbie S. Ross, T.J. Rymoff, Amanda Hutchins, Hector M. Galvez, April E. Williams, Maxim N. Shokhirev, Robert A. Screaton, Rebecca Berdeaux and Reuben J. Shaw. https://cancerdiscovery.aacrjournals.org/content/9/11/1606


Glucose / lactate


Metabolic regulation of gene expression by histone lactylation – Di Zhang, Zhanyun Tang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel Czyz, Rong Hu, Zhen Ye, Maomao He, Y. George Zheng, Howard A. Shuman, Lunzhi Dai, Bing Ren, Robert G. Roeder, Lev Becker and Yingming Zhao. https://www.nature.com/articles/s41586-019-1678-1

Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays – Jun O. Liu, Zufeng Guo, Zhiqiang Cheng, Jingxin Wang, Wukun Liu, Hanjing Peng, Yuefan Wang, Subba Rao, Ruojing Li, Xue Ying, Preethi Korangath, Maria Liberti, Yingjun Li, Yongmei Xie, Sam Hong, Cordelia Schiene-Fischer, Gunter Fischer, Jason Locasale, Saraswati Sukumar, Heng Zhu. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201905578

Near-equilibrium glycolysis supports metabolic homeostasis and energy yield – Junyoung O. Park, Lukas B. Tanner, Monica H. Wei, Daven B. Khana, Tyler B. Jacobson, Zheyun Zhang, Sara A. Rubin, Sophia Hsin-Jung Li, Meytal B. Higgins, David M. Stevenson, Daniel Amador-Noguez and Joshua D. Rabinowitz. https://www.nature.com/articles/s41589-019-0364-9


Hexosamines / gluconeogenesis


Inhibiting the hexosamine biosynthetic pathway lowers O-GlcNAcylation levels and sensitizes cancer to environmental stress – Lisa A Walter, Yu Hsuan Lin, Christopher J Halbrook, Kelly N Chuh, Lina He, Nichole J Pedowitz, Anna R Batt, Caroline K Brennan, Bangyan L. Stiles, Costas Andreas Lyssiotis, Matthew R. Pratt. https://pubs.acs.org/doi/abs/10.1021/acs.biochem.9b00560#

The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability – Vineeth Vengayil, Zeenat Rashida and Sunil Laxman. http://www.jbc.org/content/early/2019/10/11/jbc.RA119.009822.abstract

Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer – Chatchadawalai Chokchaitaweesuk, Takashi Kobayashi, Tomomi Izumikawa and Naoki Itano. https://www.nature.com/articles/s41419-019-2034-y


Cystine / Glutathione / ROS


Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation – Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB. https://www.sciencedirect.com/science/article/abs/pii/S1550413119305121

Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma – Frauke Goeman, Francesca De Nicola, Stefano Scalera, Francesca Sperati, Enzo Gallo, Ludovica Ciuffreda, Matteo Pallocca, Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Patrizia Vici, Maddalena Barba, Simonetta Buglioni, Beatrice Casini, Paolo Visca, Edoardo Pescarmona, Marco Mazzotta, Ruggero De Maria, Maurizio Fanciulli, Gennaro Ciliberto, Marcello Maugeri-Saccà. https://www.jto.org/article/S1556-0864(19)30560-X/fulltext


Other amino acids


Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism – Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31244-6

CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression – Sara Cano-Crespo, Josep Chillarón, Alexandra Junza, Gonzalo Fernández-Miranda, Judit García, Christine Polte, Laura R. de la Ballina, Zoya Ignatova, Óscar Yanes, Antonio Zorzano, Camille Stephan-Otto Attolini and Manuel Palacín. https://www.nature.com/articles/s41598-019-50547-9

Promoter demethylation of the asparagine synthetase gene is required for an ATF4-dependent adaptation to asparagine depletion – Jie Jiang, Sankalp Srivastava, Gretchen Seim, Natalya N Pavlova, Bryan King, Lihua Zou, Chi Zhang, Minghua Zhong, Hui Feng, Reuben Kapur, Ronald C. Wek, Jing Fan and Ji Zhang. http://www.jbc.org/content/early/2019/10/28/jbc.RA119.010447.abstract

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation – Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, Rachael Natrajan, Eric S. Christenson, Barbara Roman, Samarjit Das, Liang Zhao, Robert D. Leone, Daniel Shinn, Taylor Groginski, Anil K. Madugundu, Arun Patil, Daniel J. Zabransky, Arielle Medford, Justin Lee, Alex J. Cole, Marc Rosen, Maya Thakar, Alexander Ambinder, Joshua Donaldson, Amy E. DeZern, Karen Cravero, David Chu, Rafael Madero-Marroquin, Akhilesh Pandey, Paula J. Hurley, Josh Lauring and Ben Ho Park. https://www.jci.org/articles/view/125022


Nucleotides


Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers – Aarif Siddiqui, Paradesi Naidu Gollavilli, Annemarie Schwab, Maria Eleni Vazakidou, Pelin G. Ersan, Mallika Ramakrishnan, Dick Pluim, Si’Ana Coggins, Ozge Saatci, Laura Annaratone, Jan HM Schellens, Baek Kim, Irfan Ahmed Asangani, Suhail Ahmed Kabeer Rasheed, Caterina Marchiò, Ozgur Sahin and Paolo Ceppi. https://www.nature.com/articles/s41418-019-0289-6


Mitochondria


In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer – Milica Momcilovic, Anthony Jones, Sean T. Bailey, Christopher M. Waldmann, Rui Li, Jason T. Lee, Gihad Abdelhady, Adrian Gomez, Travis Holloway, Ernst Schmid, David Stout, Michael C. Fishbein, Linsey Stiles, Deepa V. Dabir, Steven M. Dubinett, Heather Christofk, Orian Shirihai, Carla M. Koehler, Saman Sadeghi and David B. Shackelford. https://www.nature.com/articles/s41586-019-1715-0

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies – Romain Guièze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández-Sánchez, Aina Martinez Zurita, Jing Sun, Elisa Ten Hacken, Kaitlyn Baranowski, Philip A. Thompson, Jin-Mi Heo, Zachary Cartun, Ozan Aygün, J. Bryan Iorgulescu, Wandi Zhang, Giulia Notarangelo, Dimitri Livitz, Shuqiang Li, Matthew S. Davids, Anat Biran, Stacey M. Fernandes, Jennifer R. Brown, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, Derin B. Keskin, Namrata D. Udeshi, William G. Wierda, Kenneth J. Livak, Anthony G. Letai, Donna Neuberg, J. Wade Harper, Steven A. Carr, Federica Piccioni, Christopher J. Ott, Ignaty Leshchiner, Cory M. Johannessen, John Doench, Vamsi K. Mootha, Gad Getz, Catherine J. Wu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30373-3

The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II – Hye-Young Min, Hyun-Ji Jang, Kwan Hee Park, Seung Yeob Hyun, So Jung Park, Ji Hye Kim, Jaekyoung Son, Sam Sik Kang and Ho-Young Lee. https://www.nature.com/articles/s41419-019-2041-z

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response – David Sharon, Severine Cathelin, Sara Mirali, Justin M. Di Trani, David J. Yanofsky, Kristine A. Keon, John L. Rubinstein, Aaron D. Schimmer, Troy Ketela and Steven M. Chan. https://stm.sciencemag.org/content/11/516/eaax2863

Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats – Min Hee Lee, Ralph J. DeBerardinis, Xiaodong Wen, Ian R.Corbin, A. Dean Sherry, Craig R. Malloy, Eunsook S.Jin. https://www.sciencedirect.com/science/article/abs/pii/S0026049519302082


Hypoxia


Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells – Ke Tang, Yuandong Yu, Liyan Zhu, Pingwei Xu, Jie Chen, Jingwei Ma, Huafeng Zhang, Haiqing Fang, Weiwei Sun, Li Zhou, Keke Wei, Fei Li, Jiadi Lv, Jing Xie, Yuying Liu and Bo Huang. https://www.nature.com/articles/s41388-019-0932-1

Effect of hypoxia on human equilibrative nucleoside transporters hENT1 and hENT2 in breast cancer – Daniel Krys, Ingrit Hamann, Melinda Wuest and Frank Wuest. https://www.fasebj.org/doi/abs/10.1096/fj.201900870RR

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma – Jinkyu Jung, Ying Zhang, Orieta Celiku, Wei Zhang, Hua Song, Brian J. Williams, Amber J. Giles, Jeremy N. Rich, Roger Abounader, Mark R. Gilbert and Deric M. Park. https://cancerres.aacrjournals.org/content/79/20/5218

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression – Yulin Shi, Songqing Fan, Mengge Wu, Zhixiang Zuo, Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu, Lin Zeng, Yongchun Zhou, Yunchao Huang, Zuozhang Yang, Jumin Zhou, Jing Gao, Hu Zhou, Shuhua Xu, Hongbin Ji, Peng Shi, Dong-Dong Wu, Cuiping Yang and Yongbin Chen. https://www.nature.com/articles/s41467-019-12801-6

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species – Hilary E. Nicholson , Zeshan Tariq, Benjamin E. Housden, Rebecca B. Jennings, Laura A. Stransky, Norbert Perrimon, Sabina Signoretti, William G. Kaelin Jr. https://stke.sciencemag.org/content/12/601/eaay0482


IDH


Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma – Makoto Nakagawa, Fumihiko Nakatani, Hironori Matsunaga, Takahiko Seki, Makoto Endo, Yoko Ogawara, Yukino Machida, Takuo Katsumoto, Kazutsune Yamagata, Ayuna Hattori, Shuhei Fujita, Yukiko Aikawa, Takamasa Ishikawa, Tomoyoshi Soga, Akira Kawai, Hirokazu Chuman, Nobuhiko Yokoyama, Suguru Fukushima, Kenichiro Yahiro, Atsushi Kimura, Eijiro Shimada, Takeshi Hirose, Toshifumi Fujiwara, Nokitaka Setsu, Yoshihiro Matsumoto, Yukihide Iwamoto, Yasuharu Nakashima and Issay Kitabayashi. https://www.nature.com/articles/s41388-019-0929-9

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis – Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan and Hai-Xin Yuan. https://www.nature.com/articles/s41419-019-1984-4

Increased 14C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with 11C-acetate PET imaging – Koyasu S, Shimizu Y, Morinibu A, Saga T, Nakamoto Y, Togashi K, Harada H. https://link.springer.com/article/10.1007%2Fs11060-019-03322-9


Miscellaneous


Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy – Marin L. Gantner, Kevin Eade, […], Christian M. Metallo and Martin Friedlander. https://www.nejm.org/doi/full/10.1056/NEJMoa1815111

Structural basis of species-selective antagonist binding to the succinate receptor – Matthias Haffke, Dominique Fehlmann, Gabriele Rummel, Jacques Boivineau, Myriam Duckely, Nina Gommermann, Simona Cotesta, Finton Sirockin, Felix Freuler, Amanda Littlewood-Evans, Klemens Kaupmann and Veli-Pekka Jaakola. https://www.nature.com/articles/s41586-019-1663-8


Reviews


A framework for examining how diet impacts tumour metabolism – Evan C. Lien and Matthew G. Vander Heiden. https://www.nature.com/articles/s41568-019-0198-5

Methionine metabolism in health and cancer: a nexus of diet and precision medicine – Sydney M. Sanderson, Xia Gao, Ziwei Dai and Jason W. Locasale. https://www.nature.com/articles/s41568-019-0187-8

The metabolic engine of endothelial cells – Kim D. Falkenberg, Katerina Rohlenova, Yonglun Luo and Peter Carmeliet. https://www.sciencedirect.com/science/article/abs/pii/S1567724919301394

Oncometabolites in renal cancer – Cissy Yong, Grant D. Stewart and Christian Frezza. https://www.nature.com/articles/s41581-019-0210-z

Growth Factors Stimulate Anabolic Metabolism by Directing Nutrient Uptake – Craig B. Thompson and Agata A. Bielska. http://www.jbc.org/content/early/2019/10/18/jbc.AW119.008146.abstract

Mitochondria orchestrate proteostatic and metabolic stress responses – Claes Andréasson, Martin Ott, Sabrina Büttner. https://www.embopress.org/doi/full/10.15252/embr.201947865

Even Cancer Cells Watch Their Cholesterol! – Romain Riscal, Nicolas Skuli, M. Celeste Simon. https://www.sciencedirect.com/science/article/abs/pii/S1097276519306938

Metabolic dependencies and vulnerabilities in leukemia – Marissa Rashkovan and Adolfo Ferrando. http://genesdev.cshlp.org/content/33/21-22/1460.abstract?etoc

Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease – Shijia Huang, Yuying Xing and Yong Liu. http://www.jbc.org/content/early/2019/10/30/jbc.REV119.007036.abstract

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function – Xiaozhen Dai, Xiaoqing Yan, Kupper A. Wintergerst, Lu Cai, Bradley B. Keller, Yi Tan. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30246-1

The Rise of Physiologic Media – Jason R. Cantor. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30145-X


Comments


Histone lactylation links metabolism and gene regulation – Luke T. Izzo, Kathryn E. Wellen. https://www.nature.com/articles/d41586-019-03122-1

Metabolic vulnerability in tumours illuminated – Aparna D. Rao and Ralph J. DeBerardinis. https://www.nature.com/articles/d41586-019-03239-3

Mutations in the Antioxidant KEAP1/NRF2 Pathway Define an Aggressive Subset of NSCLC Resistant to Conventional Treatments – Ernest Nadal, Ramon Palmero, Cristina Muñoz-Pinedo. https://www.jto.org/article/S1556-0864(19)30672-0/fulltext

Suppressed fate [alpha-KG] – Anna Dart. https://www.nature.com/articles/s41568-019-0215-8

Arkaitz Carracedo: If the scientific question is good, the result will be interesting – Houston S. http://jem.rupress.org/content/early/2019/10/14/jem.20191880.long

MetaboList – September 2019


Glucose metabolism / glycolytic enzymes


GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism – Laura Mondragón, Rana Mhaidly, Gian Marco De Donatis, Marie Tosolini, Pascal Dao, Anthony R. Martin, Caroline Pons, Johanna Chiche, Marie Jacquin, Véronique Imbert, Emma Proïcs, Laurent Boyer, Anne Doye, Frédéric Luciano, Jaap G. Neels, Frédéric Coutant, Nicole Fabien, Laura Sormani, Camila Rubio-Patiño, Jozef P. Bossowski, Florian Muller, Sandrine Marchetti, Elodie Villa, Jean-François Peyron, Philippe Gaulard, François Lemonnier, Vahid Asnafi, Laurent Genestier, Rachid Benhida, Jean-Jacques Fournié, Thierry Passeron, Jean-Ehrland Ricci, Els Verhoeyen. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30335-6

Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival – Yu-Chan Chang, Jean Chiou, Yi-Fang Yang, Chia-Yi Su, Yuan-Feng Lin, Chia-Ning Yang, Pei-Jung Lu, Ming-Shyan Huang, Chih-Jen Yang and Michael Hsiao. https://cancerres.aacrjournals.org/content/79/18/4754

Targeting a moonlighting function of aldolase induces apoptosis in cancer cells – Agnieszka Gizak, Janusz Wiśniewski, Paul Heron, Piotr Mamczur, Jurgen Sygusch and Dariusz Rakus. https://www.nature.com/articles/s41419-019-1968-4

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers – Hailing Yang, Zhang Shu, Yongying Jiang, Weiqun Mao, Lan Pang, Abena Redwood, Sabrina L. Jeter-Jones, Nicholas B. Jennings, Argentina Ornelas, Jinhua Zhou, Cristian Rodriguez-Aguayo, Geoffrey Bartholomeusz, LaKesla R. Iles, Niki M. Zacharias, Steven W. Millward, Gabriel Lopez-Berestein, Xiao-Feng Le, Ahmed A. Ahmed, Helen Piwnica-Worms, Anil K. Sood, Robert C. Bast and Zhen Lu. https://clincancerres.aacrjournals.org/content/25/18/5702

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose – Quentin Defenouillère, Agathe Verraes, Clotilde Laussel, Anne Friedrich, Joseph Schacherer, Sébastien Léon. https://stke.sciencemag.org/content/12/597/eaaw8000

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition – Mauro Siragusa, Janina Thöle, Sofia‐Iris Bibli, Bert Luck, Annemarieke E Loot, Kevin de Silva, Ilka Wittig, Juliana Heidler, Heike Stingl, Voahanginirina Randriamboavonjy, Karin Kohlstedt, Bernhard Brüne, Andreas Weigert, Beate Fisslthaler, Ingrid Fleming. https://www.embopress.org/doi/abs/10.15252/embj.2018100938

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma – Sarah A. Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E. Vince, Vivek Rathi, Gavin M. Wright, Matthew E. Ritchie and Kate D. Sutherland. https://www.nature.com/articles/s41467-019-12164-y

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis – Yuan Fang, Zhi-Yong Shen, Yi-Zhi Zhan, Xiao-Chuang Feng, Ke-Li Chen, Yong-Sheng Li, Hai-Jun Deng, Su-Ming Pan, De-Hua Wu and Yi Ding. https://www.nature.com/articles/s41467-019-11662-3

Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells – Johanna Erber, Joachim D. Steiner, Jörg Isensee, Leonard A. Lobbes, André Toschka, Filippo Beleggia, Anna Schmitt, Rainer W. J. Kaiser, Florian Siedek, Thorsten Persigehl, Tim Hucho and Hans C. Reinhardt. https://cancerres.aacrjournals.org/content/79/19/4855

PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses – Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Ling Jin, Debarshi Roy, Deokbeom Jung, Yinan Xiao, Julie Staub, Bhaskar Roy, Julian R. Molina and Viji Shridhar. https://www.nature.com/articles/s41419-019-1916-3

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling – Arnaud Tauffenberger, Hubert Fiumelli, Salam Almustafa and Pierre J. Magistretti. https://www.nature.com/articles/s41419-019-1877-6


Amino acids


Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation – Frances F. Diehl, Caroline A. Lewis, Brian P. Fiske and Matthew G. Vander Heiden. https://www.nature.com/articles/s42255-019-0108-x

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation – Zhimin Gu, Yuxuan Liu, Feng Cai, McKenzie Patrick, Jakub Zmajkovic, Hui Cao, Yuannyu Zhang, Alpaslan Tasdogan, Mingyi Chen, Le Qi, Xin Liu, Kailong Li, Junhua Lyu, Kathryn E. Dickerson, Weina Chen, Min Ni, Matthew E. Merritt, Sean J. Morrison, Radek C. Skoda, Ralph J. DeBerardinis and Jian Xu. https://cancerdiscovery.aacrjournals.org/content/9/9/1228

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer – Michael J. Lukey, Ahmad A. Cluntun, William P. Katt, Miao-chong J. Lin, Joseph E. Druso, Sekar Ramachandran, Jon W. Erickson, Henry H. Le, Zhihan-Emily Wang, Bryant Blank, Kai Su Greene, Richard A. Cerione. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31131-3

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer – Niranjan Venkateswaran, M. Carmen Lafita-Navarro, Yi-Heng Hao, Jessica A Kilgore, Lizbeth Perez-Castro, Jonathan Braverman, Nofit Borenstein-Auerbach, Min Kim, Nicholas P. Lesner, Prashant Mishra, Thomas Brabletz, Jerry W. Shay, Ralph J. DeBerardinis, Noelle S. Williams, Omer H. Yilmaz and Maralice Conacci-Sorrell. http://genesdev.cshlp.org/content/33/17-18/1236.abstract?etoc

Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine – Sabrina Z. Wang, Brad Poore, Jesse Alt, Antoinette Price, Sariah J. Allen, Allison R. Hanaford, Harpreet Kaur, Brent A. Orr, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe and Jeffrey A. Rubens. https://clincancerres.aacrjournals.org/content/25/19/5925


Lipid metabolism


The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth – Arvin M. Gouw, Katherine Margulis, Natalie S. Liu, Sudha J. Raman, Anthony Mancuso, Georgia G. Toal, Ling Tong, Adriane Mosley, Annie L. Hsieh, Delaney K. Sullivan, Zachary E. Stine, Brian J. Altman, Almut Schulze, Chi V. Dang, Richard N. Zare, Dean W. Felsher. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30385-7

Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling – Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie and Jeremy N. Rich. https://cancerdiscovery.aacrjournals.org/content/9/9/1248

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis – Rajni Kumari, Ruhi S. Deshmukh and Sanjeev Das. https://www.nature.com/articles/s41467-019-12194-6


Nucleotides / one carbon


Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation – Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A. Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A. Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P. Gygi, Vamsi K. Mootha, Michael P. Weekes, Benjamin E. Gewurz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30306-7

Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis – Xiaoqian Jing, Xiong-jun Wang, Tao Zhang, Wencheng Zhu, Yi Fang, Haoxuan Wu, Xinyu Liu, Ding Ma, Xiaopin Ji, Yimei Jiang, Kun Liu, Xianze Chen, Yi Shi, Yaqi Zhang, Minmin Shi, Weihua Qiu and Ren Zhao. https://cancerres.aacrjournals.org/content/79/18/4650


Mitochondria


α-Ketoglutarate links p53 to cell fate during tumour suppression – John P. Morris IV, Jossie J. Yashinskie, Richard Koche, Rohit Chandwani, Sha Tian, Chi-Chao Chen, Timour Baslan, Zoran S. Marinkovic, Francisco J. Sánchez-Rivera, Steven D. Leach, Carlos Carmona-Fontaine, Craig B. Thompson, Lydia W. S. Finley and Scott W. Lowe. https://www.nature.com/articles/s41586-019-1577-5

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis – Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31014-9

Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance – Kazuhiro Ikeda, Kuniko Horie-Inoue, Takashi Suzuki, Rutsuko Hobo, Norie Nakasato, Satoru Takeda and Satoshi Inoue. https://www.nature.com/articles/s41467-019-12124-6

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+ – Jing Yong, Helmut Bischof, Sandra Burgstaller, Marina Siirin, Anne Murphy, Roland Malli, Randal J Kaufman. https://elifesciences.org/articles/49682

Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells – Xingyu Wu, Huwate Yeerna, Yusuke Goto, Toshinori Ando, Victoria H. Wu, Xuefeng Zhang, Zhiyong Wang, Panomwat Amornphimoltham, Anne N. Murphy, Pablo Tamayo, Qianming Chen, Scott M. Lippman and J. Silvio Gutkind. https://cancerres.aacrjournals.org/content/79/17/4360


Starvation / nutrient sensing


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK – Mengqi Li, Chen-Song Zhang, Yue Zong, Jin-Wei Feng, Teng Ma, Meiqin Hu, Zhizhong Lin, Xiaotong Li, Changchuan Xie, Yaying Wu, Dong Jiang, Ying Li, Cixiong Zhang, Xiao Tian, Wen Wang, Yanyan Yang, Jie Chen, Jiwen Cui, Yu-Qing Wu, Xin Chen, Qing-Feng Liu, Jianfeng Wu, Shu-Yong Lin, Zhiyun Ye, Ying Liu, Hai-Long Piao, Li Yu, Zhuan Zhou, Xiao-Song Xie, D. Grahame Hardie, Sheng-Cai Lin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30258-X

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk – Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson and Luigi Puglielli. https://www.nature.com/articles/s41467-019-11945-9

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2 – Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida, Shinjiro Hino, Akihisa Sakamoto, Kaori Igarashi, Kaori Saitoh, Keiko Kato, Keiko Endo, Shotaro Yamano, Yasuharu Kanki, Yoshihiro Matsumura, Takashi Minami, Toshiya Tanaka, Motonobu Anai, Youichiro Wada, Hideki Wanibuchi, Mitsuhiro Hayashi, Akinobu Hamada, Masayuki Yoshida, Shinichi Yachida, Mitsuyoshi Nakao, Juro Sakai, Hiroyuki Aburatani, Masabumi Shibuya, Kentaro Hanada, Satoru Miyano, Tomoyoshi Soga, Tatsuhiko Kodama. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31149-0

ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis – Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Stella Y. Lee, Jian Li, Ming Bai, Claudia Alves, William Tseng, Xavier Michelet, I-Cheng Ho and Victor W. Hsu. https://www.nature.com/articles/s41467-019-11932-0

Age modulates liver responses to asparaginase-induced amino acid stress in mice – Inna A. Nikonorova, Qiaoqiao Zhu, Christina C. Signore, Emily T. Mirek, William O. Jonsson, Bo Kong, Grace L. Guo, William J. Belden and Tracy G. Anthony. http://www.jbc.org/content/294/38/13864.abstract.html


mTOR


Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling – Arunas Kvainickas, Heike Nägele, Wenjing Qi, Ladislav Dokládal, Ana Jimenez-Orgaz, Luca Stehl, Dipak Gangurde, Qian Zhao, Zehan Hu, Jörn Dengjel, Claudio De Virgilio, Ralf Baumeister and Florian Steinberg. http://jcb.rupress.org/content/218/9/3019?etoc

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1 – Alexander Wallroth, Philipp A. Koch, Andrea L. Marat, Eberhard Krause and Volker Haucke. https://www.nature.com/articles/s41556-019-0377-3

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin – Long He, Dennis Liang Fei, Michal J. Nagiec, Anders P. Mutvei, Andreas Lamprakis, Bo Yeon Kim and John Blenis. https://www.pnas.org/content/116/39/19523.abstract?etoc


AMPK


Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer – Xue Han, Chune Ren, Tingting Yang, Pengyun Qiao, Li Wang, Aifang Jiang, Yuhan Meng, Zhijun Liu, Yu Du and Zhenhai Yu. https://www.nature.com/articles/s41388-019-0898-z

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling – Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen & Steven H. Lin. https://www.nature.com/articles/s41467-019-12377-1


Hypoxia / HIF


Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization – Christiaan F. Labuschagne, Eric C. Cheung, Julianna Blagih, Marie-Charlotte Domart, Karen H. Vousden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30387-0

Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer – Avihai Ron, Xosé Luís Deán-Ben, Sven Gottschalk and Daniel Razansky. https://cancerres.aacrjournals.org/content/79/18/4767

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species – Hilary E. Nicholson, Zeshan Tariq, Benjamin E. Housden, Rebecca B. Jennings, Laura A. Stransky, Norbert Perrimon, Sabina Signoretti and William G. Kaelin Jr. https://stke.sciencemag.org/content/12/601/eaay0482


Cancer Immunometabolism


Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy – Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby, Marina Kreutz. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31123-4

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence – Michal Harel, Rona Ortenberg, Siva Karthik Varanasi, Kailash Chandra Mangalhara, Mariya Mardamshina, Ettai Markovits, Erez N. Baruch, Victoria Tripple, May Arama-Chayoth, Eyal Greenberg, Anjana Shenoy, Ruveyda Ayasun, Naama Knafo, Shihao Xu, Liat Anafi, Gali Yanovich-Arad, Georgina D. Barnabas, Shira Ashkenazi, Michal J. Besser, Jacob Schachter, Marcus Bosenberg, Gerald S. Shadel, Iris Barshack, Susan M. Kaech, Gal Markel, Tamar Geiger. ttps://www.cell.com/cell/fulltext/S0092-8674(19)30900-6

T Cell Activation Depends on Extracellular Alanine – Noga Ron-Harel, Jonathan M. Ghergurovich, Giulia Notarangelo, Arlene H. Sharpe, Joshua D. Rabinowitz, Marcia C. Haigis. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31074-5?dgcid=raven_jbs_etoc_email

AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells – Jimena Trillo-Tinoco, Rosa A. Sierra, Eslam Mohamed, Yu Cao, Álvaro de Mingo-Pulido, Danielle L. Gilvary, Carmen M. Anadon, Tara Lee Costich, Sheng Wei, Elsa R. Flores, Brian Ruffell, José R. Conejo-Garcia and Paulo C. Rodriguez. https://cancerres.aacrjournals.org/content/79/19/5034


Miscellaneous


High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program – David P. Labbé, Giorgia Zadra, […]Myles Brown. https://www.nature.com/articles/s41467-019-12298-z

PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis – Dingzhi Wang, Lingchen Fu, Jie Wei, Ying Xiong and Raymond N. DuBois. https://cancerres.aacrjournals.org/content/79/17/4480

Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development – Anni M.Y. Zhang, Jamie Magrill, Twan J.J. de Winter, Xiaoke Hu, Søs Skovsø, David F. Schaeffer, Janel L. Kopp, James D. Johnson. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30376-6

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E – Ying Zhang, Stefan Pusch, James Innes, Kastytis Sidlauskas, Matthew Ellis, Joanne Lau, Tedani El-Hassan, Natasha Aley, Francesca Launchbury, Angela Richard-Loendt, Jasper deBoer, Sheng Chen, Lei Wang, Andreas von Deimling, Ningning Li and Sebastian Brandner. https://cancerres.aacrjournals.org/content/79/19/4994


Reviews


Mechanisms and Implications of Metabolic Heterogeneity in Cancer – Jiyeon Kim, Ralph J. DeBerardinis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30442-5

Hallmarks of Endothelial Cell Metabolism in Health and Disease – Xuri Li, Xiaodong Sun, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30440-1

Metabolic implications of organelle–mitochondria communication – Isabel Gordaliza‐Alaguero, Carlos Cantó, Antonio Zorzano. https://www.embopress.org/doi/abs/10.15252/embr.201947928


Comments


Epigenetic Control of Fatty-Acid Metabolism Sustains Glioma Stem Cells – Hayley C. Affronti and Kathryn E. Wellen. https://cancerdiscovery.aacrjournals.org/content/9/9/1161

United They Stand, Divided They Fall – Isaac S. Harris, Joan S. Brugge. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30496-6

Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D – Alexander L. Klibanov and Song Hu. https://cancerres.aacrjournals.org/content/79/18/4577

Membrane Lipid Remodeling Takes Center Stage in Growth Factor Receptor-Driven Cancer Development – Johannes V. Swinnen, Jonas Dehairs, Ali Talebi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30445-0

Essentiality of non-essential amino acids for tumour cells and tumorigenesis – Chi V. Dang. https://www.nature.com/articles/s42255-019-0113-0

Bone Marrow: An Immunometabolic Refuge during Energy Depletion – Emily L. Goldberg, Vishwa Deep Dixit. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30496-6