MetaboList – April 2019


Resources


Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability – Mark R Sullivan, Laura V Danai, Caroline A Lewis, Sze Ham Chan, Dan Y Gui, Tenzin Kunchok, Emily A Dennstedt, Matthew G Vander Heiden, Alexander Muir. https://elifesciences.org/articles/44235

Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism – Karin Ortmayr, Sébastien Dubuis and Mattia Zampieri. https://www.nature.com/articles/s41467-019-09695-9


Amino acid metabolism


Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias – Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, Joshua Sacher, Kristen E. Stevenson, Donna S. Neuberg, Esteban Orellana, Martin Stanulla, Richard I. Gregory, Daniel E. Bauer, Florence F. Wagner, Kimberly Stegmaier, Alejandro Gutierrez. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30149-7

Nutrient Stress–Dysregulated Antisense lncRNA GLS-AS Impairs GLS-Mediated Metabolism and Represses Pancreatic Cancer Progression – Shi-Jiang Deng, Heng-Yu Chen, Zhu Zeng, Shichang Deng, Shuai Zhu, Zeng Ye, Chi He, Ming-Liang Liu, Kang Huang, Jian-Xin Zhong, Feng-Yu Xu, Qiang Li, Yang Liu, Chunyou Wang and Gang Zhao. http://cancerres.aacrjournals.org/content/79/7/1398

Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL – Aurore Touzart, Etienne Lengliné, Mehdi Latiri, Mohamed Belhocine, Charlotte Smith, Xavier Thomas, Salvatore Spicuglia, Denis Puthier, Françoise Pflumio, Thibaut Leguay, Carlos Graux, Yves Chalandon, Françoise Huguet, Stéphane Leprêtre, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Mathilde Hunault, Nicolas Boissel and Vahid Asnafi. http://clincancerres.aacrjournals.org/content/25/8/2483

Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma – Raj Shah, Simar J. Singh, Kevinn Eddy, Fabian V. Filipp and Suzie Chen. http://cancerres.aacrjournals.org/content/79/8/1799

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 – Tong Liu, Le Jiang, Omid Tavana and Wei Gu. http://cancerres.aacrjournals.org/content/79/8/1913

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex – Renhong Yan, Xin Zhao, Jianlin Lei and Qiang Zhou. https://www.nature.com/articles/s41586-019-1011-z

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer – Tu Nguyen, Brian James Kirsch, Ryoichi Asaka, Karim Nabi, Addison Quinones, Jessica Tan, Marjorie Justine Antonio, Felipe Camelo, Ting Li, Stephanie Nguyen, Giang Hoang, Kiet Nguyen, Sunag Udupa, Christos Sazeides, Yao-An Shen, Amira Elgogary, Juvenal Reyes, Liang Zhao, Andre Kleensang, Kaisorn Lee Chaichana, Thomas Hartung, Michael J. Betenbaugh, Suely K. Marie, Jin G. Jung, Tian-Li Wang, Edward Gabrielson, Anne Le. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30352-3

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer – Yasuhiro Saito, Lewyn Li, Etienne Coyaud, Augustin Luna, Chris Sander, Brian Raught, John M. Asara, Myles Brown and Senthil K. Muthuswamy. https://www.nature.com/articles/s41586-019-1126-2


Lipid and acetyl-CoA metabolism


An allosteric mechanism for potent inhibition of human ATP-citrate lyase – Jia Wei, Silvana Leit, Jun Kuai et al. https://www.nature.com/articles/s41586-019-1094-6

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle – Koen H. G. Verschueren, Clement Blanchet, Jan Felix et al. https://www.nature.com/articles/s41586-019-1095-5

Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content – Charleston F. Christie, Diana Fang, Elizabeth G. Hunt, Morgan E. Morris, Amandine Rovini, Kareem A. Heslop, Gyda C. Beeson, Craig C. Beeson and Eduardo N. Maldonado. https://www.fasebj.org/doi/abs/10.1096/fj.201802723R?ai=ts&ui=ly8&af=T

ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition – Ming Lu, Wen-Wei Zhu, Xuan Wang, Jing-Jie Tang, Kai-Li Zhang, Guang-Yang Yu, Wei-Qing Shao, Zhi-Fei Lin, Sheng-Hao Wang, Lu Lu, Jian Zhou, Lian-Xin Wang, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Hong Chen, Jian-Quan Lu, Lun-Xiu Qin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30756-3


Nucleotides and NAD


NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling – Sudhir Chowdhry, Ciro Zanca, Utkrisht Rajkumar, Tomoyuki Koga, Yarui Diao, Ramya Raviram, Feng Liu, Kristen Turner, Huijun Yang, Elizabeth Brunk, Junfeng Bi, Frank Furnari, Vineet Bafna, Bing Ren and Paul S. Mischel. https://www.nature.com/articles/s41586-019-1150-2

Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion – Irmina A. Elliott, Amanda M. Dann, Shili Xu, Stephanie S. Kim, Evan R. Abt, Woosuk Kim, Soumya Poddar, Alexandra Moore, Lei Zhou, Jennifer L. Williams, Joseph R. Capri, Razmik Ghukasyan, Cynthia Matsumura, D. Andrew Tucker, Wesley R. Armstrong, Anthony E. Cabebe, Nanping Wu, Luyi Li, Thuc M. Le, Caius G. Radu and Timothy R. Donahue. https://www.pnas.org/content/116/14/6842.abstract?etoc

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2 – Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo and Noriko Gotoh. https://www.nature.com/articles/s41388-018-0589-1


Mitochondria


ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis – Eduardo Balsa, Meghan S.Soustek, Ajith Thomas, Sara Cogliati, Carolina García-Poyatos, Elena Martín-García, Mark Jedrychowski, Steve P. Gygi, José Antonio Enriquez, Pere Puigserver. https://www.sciencedirect.com/science/article/pii/S1097276519302357

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer – Rahul Kumar, Tariq A. Bhat, Elise M. Walsh, Ajay K. Chaudhary, Jordan O’Malley, Johng S. Rhim, Jianmin Wang, Carl D. Morrison, Kristopher Attwood, Wiam Bshara, James L. Mohler, Neelu Yadav and Dhyan Chandra. http://cancerres.aacrjournals.org/content/79/7/1353

Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance – Karim Fekir, Hélène Dubois-Pot-Schneider, Romain Désert, Yoann Daniel, Denise Glaise, Claudine Rauch, Fabrice Morel, Bernard Fromenty, Orlando Musso, Florian Cabillic and Anne Corlu. http://cancerres.aacrjournals.org/content/79/8/1869

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate – Valentina Sica, Jose Manuel Bravo-San Pedro, Valentina Izzo, Jonathan Pol, Sandra Pierredon, David Enot, Sylvère Durand, Noélie Bossut, Alexis Chery, Sylvie Souquere, Gerard Pierron, Evangelia Vartholomaiou, Naoufal Zamzami, Thierry Soussi, Allan Sauvat, Laura Mondragón, Oliver Kepp, Lorenzo Galluzzi, Jean-Claude Martinou, Holger Hess-Stumpp, Karl Ziegelbauer, Guido Kroemer, Maria Chiara Maiuri. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30388-2

Mitochondrial metabolism is inhibited by the HIF1α‐MYC‐PGC‐1β axis in BRAF V600E thyroid cancer – Yanyan Gao, Fang Yang, Xiu‐An Yang, Li Zhang,Huixin Yu, Xian Cheng, Shichen Xu, Jie Pan, Kun Wang, Peifeng Li. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14786

Lactic acidosis due to repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the PDK/PDH axis – Sun Mi Hong, Young-Kyoung Lee, Imkyong Park, So Mee Kwon, Seongki Min and Gyesoon Yoon. http://www.jbc.org/content/early/2019/03/28/jbc.RA118.006095.abstract

TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle – Ji Geng, Mingzhen Wei, Xiao Yuan, Ziqi Liu, Xinxin Wang, Dingmei Zhang, Li Luo, Junchao Wu, Wenjie Guo and Zheng-Hong Qin. https://www.fasebj.org/doi/abs/10.1096/fj.201802209R?ai=s4&ui=ly8&af=T


Starvation / Nutrient sensing


Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation– Hyunju Cho, Francesca Stanzione, Amrita Oak, Geun Hyang Kim, Sindura Yerneni, Ling Qi, Amadeu K. Sum, Christina Chan. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30324-9

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation – Katarzyna Parzych, Paula Saavedra-García, Gabriel N. Valbuena, Hibah A. Al-Sadah, Mark E. Robinson, Lucy Penfold, Desislava M. Kuzeva, Angie Ruiz-Tellez, Sandra Loaiza, Viktoria Holzmann, Valentina Caputo, David C. Johnson, Martin F. Kaiser, Anastasios Karadimitris, Eric W-F Lam, Eric Chevet, Niklas Feldhahn, Hector C. Keun and Holger W. Auner. https://www.nature.com/articles/s41388-018-0651-z

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids – Manuele Piccolis, Laura M. Bond, Martin Kampmann, Pamela Pulimeno, Chandramohan Chitraju, Christina B.K. Jayson, Laura P. Vaites, Sebastian Boland, Zon Weng Lai, Katlyn R. Gabriel, Shane D. Elliott, Joao A. Paulo, J. Wade Harper, Jonathan S. Weissman, Tobias C. Walther, Robert V. Farese Jr. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30056-5

Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts – Satoshi Kameshima, Muneyoshi Okada and Hideyuki Yamawaki. https://link.springer.com/article/10.1007/s10495-019-01525-z


mTOR / AMPK


Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation – Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30397-3

Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling – Gabriella M. Forte, Elizabeth Davie, Shervi Lie, Mirita Franz-Wachtel,Ashley J. Ovens, Tingting Wang, Jonathan S. Oakhill, Boris Maček, Iain M.Hagan and Janni Petersen. http://jcs.biologists.org/content/132/7/jcs223925?etoc

Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth – Yu-San Yang, Masato Kato, Xi Wu, Athanasios Litsios, Benjamin M. Sutter, Yun Wang, Chien-Hsiang Hsu, N. Ezgi Wood, Andrew Lemoff, Hamid Mirzaei, Matthias Heinemann, Benjamin P. Tu. https://www.cell.com/cell/fulltext/S0092-8674(19)30226-0

TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila – Byoungchun Lee, Elizabeth C. Barretto and Savraj S. Grewal. https://www.nature.com/articles/s41467-019-09643-7


Hypoxia


Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy – Youqiong Ye, Qingsong Hu, Hu Chen, Ke Liang, Yuan Yuan, Yu Xiang, Hang Ruan, Zhao Zhang, Anren Song, Huiwen Zhang, Lingxiang Liu, Lixia Diao, Yanyan Lou, Bingying Zhou, Li Wang, Shengtao Zhou, Jianjun Gao, Eric Jonasch, Steven H. Lin, Yang Xia, Chunru Lin, Liuqing Yang, Gordon B. Mills, Han Liang and Leng Han. https://www.nature.com/articles/s42255-019-0045-8

A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma – Daniel M. Lewis, Hawley Pruitt, Nupur Jain, Mark Ciccaglione, J. Michael McCaffery, Zhiyong Xia, Kristy Weber, T.S. Karin Eisinger-Mathason and Sharon Gerecht. http://cancerres.aacrjournals.org/content/79/8/1981


Cancer immunometabolism


Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells – Fei Chen, Jianing Chen, Linbin Yang, Jiang Liu, Xiaoqian Zhang, Yin Zhang, Qingqiang Tu, Dong Yin, Dechen Lin, Ping-Pui Wong, Di Huang, Yue Xing, Jinghua Zhao, Mengfeng Li, Qiang Liu, Fengxi Su, Shicheng Su and Erwei Song. https://www.nature.com/articles/s41556-019-0299-0

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma – Jason Miska, Catalina Lee-Chang, Aida Rashidi, Megan E. Muroski, Alan L. Chang, Aurora Lopez-Rosas, Peng Zhang, Wojciech K. Panek, Alex Cordero, Yu Han, Atique U. Ahmed, Navdeep S. Chandel, Maciej S. Lesniak. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30345-6

Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes – Ling Li, Bangrong Cao, Xinhua Liang, Shun Lu, Huaichao Luo, Zhaohui Wang, Shaoxin Wang, Jian Jiang, Jinyi Lang and Guiquan Zhu. https://www.nature.com/articles/s41388-018-0627-z

Fatty acid transport protein 2 reprograms neutrophils in cancer – Filippo Veglia, Vladimir A. Tyurin, Maria Blasi, Alessandra De Leo, Andrew V. Kossenkov, Laxminarasimha Donthireddy, Tsun Ki Jerrick To, Zach Schug, Subhasree Basu, Fang Wang, Emanuela Ricciotti, Concetta DiRusso, Maureen E. Murphy, Robert H. Vonderheide, Paul M. Lieberman, Charles Mulligan, Brian Nam, Neil Hockstein, Gregory Masters, Michael Guarino, Cindy Lin, Yulia Nefedova, Paul Black, Valerian E. Kagan and Dmitry I. Gabrilovich. https://www.nature.com/articles/s41586-019-1118-2


Miscellaneous


Stratification of cancer and diabetes based on circulating levels of formate and glucose – Matthias Pietzke, Salvador Fernandez Arroyo, David Sumpton, Gillian M. Mackay, Begoña Martin-Castillo, Jordi Camps, Jorge Joven, Javier A. Menendez and Alexei Vazquez. https://cancerandmetabolism.biomedcentral.com/

The adverse effect of gentamicin on cell metabolism in three cultured mammary cell lines: “Are cell culture data skewed?” – Robert L. Elliott, Xian-Peng Jiang. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214586


Reviews


Energy metabolism in cachexia – Maria Rohm, Anja Zeigerer, Juliano Machado and Stephan Herzig. http://EMBOr.embopress.org/content/20/4/e47258?etoc

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism – Vikramjit Lahiri, Wayne D. Hawkins, Daniel J. Klionsky. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30131-7

Targeting Metabolic–Redox Circuits for Cancer Therapy – Kui Wang, Jingwen Jiang, Yunlong Lei, Shengtao Zhou, Yuquan Wei, Canhua Huang. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30001-5

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells – Petra Jagust, Beatriz de Luxán-Delgado, Beatriz Parejo-Alonso and Patricia Sancho. https://www.frontiersin.org/articles/10.3389/fphar.2019.00203/full

Mitochondrial stress-dependent regulation of cellular protein synthesis – Ulrike Topf, Barbara Uszczynska-Ratajczak and Agnieszka Chacinska. http://jcs.biologists.org/content/132/8/jcs226258?etoc

Micromanaging aerobic respiration and glycolysis in cancer cells – Ayla V. Orang, Janni Petersen, Ross A. McKinnon, Michael Z. Michael. https://www.sciencedirect.com/science/article/pii/S2212877818311128

The mystery of metformin – Martin J. Spiering. http://www.jbc.org/content/294/17/6689.full.html


Comments


Several Faces of Glutaminase Regulation in Cells – Ana C.P. Mafra and Sandra M.G. Dias. http://cancerres.aacrjournals.org/content/79/7/1302

Metabolic Adaptation Fuels Lymph Node Metastasis – Jessalyn M. Ubellacker, Sean J. Morrison. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30134-2

Mechanical forces rewire metabolism in the tumor niche – Thomas Bertero and Cedric Gaggioli. https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1592945

Uncovering Plasticity in Tumor Lipid Metabolism – http://cancerdiscovery.aacrjournals.org/content/9/4/456.2

Renovation in progress [pyruvate] – Ulrike Harjes. https://www.nature.com/articles/s41568-019-0131-y

Overflow [of glucose] disrupts the genome – Ulrike Harjes. https://www.nature.com/articles/s41568-019-0136-6

Targeting cancer cell metabolism in glioblastoma – Sarah Crunkhorn. https://www.nature.com/articles/s41568-019-0139-3

MetaboList – March 2019


Glucose metabolism


Breast cancer cells rely on environmental pyruvate to shape the metastatic niche – Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Marit van Gorsel, Ruben Boon, Carmen Escalona-Noguero, Sophie Torrekens, Catherine Verfaillie, Erik Verbeken, Geert Carmeliet and Sarah-Maria Fendt. https://www.nature.com/articles/s41586-019-0977-x

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells – Bai Cui, Yuanyuan Luo, Pengfei Tian, Fei Peng, Jinxin Lu, Yongliang Yang, Qitong Su, Bing Liu, Jiachuan Yu, Xi Luo, Liu Yin, Wei Cheng, Fan An, Bin He, Dapeng Liang, Sijin Wu, Peng Chu, Luyao Song, Xinyu Liu, Huandong Luo, Jie Xu, Yujia Pan, Yang Wang, Dangsheng Li, Peng Huang, Qingkai Yang, Lingqiang Zhang, Binhua P. Zhou, Suling Liu, Guowang Xu, Eric W.-F. Lam, Keith W. Kelley and Quentin Liu. https://www.jci.org/articles/view/121685

Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming – Pere Llinàs-Arias, Margalida Rosselló-Tortella, Paula Lopez-Serra, Montserrat Pérez-Salvia, Fernando Setién, Silvia Marin, Juan P. Muñoz, Alexandra Junza, Jordi Capellades, Maria E. Calleja-Cervantes, Humberto J. Ferreira, Manuel Castro de Moura, Marina Srbic, Anna Martínez-Cardús, Carolina de la Torre, Alberto Villanueva, Marta Cascante, Oscar Yanes, Antonio Zorzano, Catia Moutinho and Manel Esteller. https://insight.jci.org/articles/view/125888#

Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells – Dong Jun Kim, Mai-Tram Vo, Seong Hee Choi, Ji-Heon Lee, So Yeon Jeong, Chung Hwan Hong, Jong Soo Kim, Unn Hwa Lee, Hyung-Min Chung, Byung Ju Lee, Wha Ja Cho and Jeong Woo Park. https://www.molbiolcell.org/doi/10.1091/mbc.E18-09-0606

High-fructose corn syrup enhances intestinal tumor growth in mice – Marcus D. Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, Sam Taylor, Kaitlyn Bosch, Sukjin Yang, Yumei Wang, Justin Van Riper, H Carl Lekaye, Jatin Roper, Young Kim, Qiuying Chen, Steven S. Gross, Kyu Y. Rhee, Lewis C. Cantley, Jihye Yun. http://science.sciencemag.org/content/363/6433/1345

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance – Ruilong Liu, Wenfeng Li, Bangbao Tao, Xiongjun Wang, Zhuo Yang, Yajuan Zhang, Chenyao Wang, Rongzhi Liu, Hong Gao, Ji Liang and Weiwei Yang. https://www.nature.com/articles/s41467-019-08921-8


Glutamine metabolism


Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth – Sameer H. Issaq, Arnulfo Mendoza, Stephen D. Fox and Lee J. Helman. https://www.nature.com/articles/s41389-019-0129-z

Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells – Won Dong Lee, Dzmitry Mukha, Elina Aizenshtein and Tomer Shlomi. https://www.nature.com/articles/s41467-019-09352-1

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma – Shuo Qie, Akihiro Yoshida, Stuart Parnham, Natalia Oleinik, Gyda C. Beeson, Craig C. Beeson, Besim Ogretmen, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi and J. Alan Diehl. https://www.nature.com/articles/s41467-019-09179-w

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression – Fang Ni, Wen-Mei Yu, Zhiguo Li, Douglas K. Graham, Lingtao Jin, Sumin Kang, Michael R. Rossi, Shiyong Li, Hal E. Broxmeyer and Cheng-Kui Qu. https://www.nature.com/articles/s42255-019-0039-6

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells – Angelika Bröer, Gregory Gauthier-Coles, Farid Rahimi, Michelle van Geldermalsen, Dieter Dorsch, Ansgar Wegener, Jeff Holst and Stefan Bröer. http://www.jbc.org/content/294/11/4012.abstract.html

BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase – Song Zhao, Jia-Mei Wang, Jing Yan, Da-Lin Zhang, Bao-Qin Liu, Jing-Yi Jiang, Chao Li, Si Li, Xiao-Na Meng and Hua-Qin Wang. https://www.nature.com/articles/s41419-019-1504-6

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake – Xazmin H. Lowman, Eric A. Hanse, Ying Yang, Mari B. Ishak Gabra, Thai Q. Tran, Haiqing Li, Mei Kong. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30208-6


Amino acid metabolism: other


SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis – Feng Du, Jie Chen, Hao Liu, Yanhui Cai, Tianyu Cao, Weili Han, Xiaofang Yi, Meirui Qian, Dean Tian,Yongzhan Nie, Kaichun Wu, Daiming Fan and Limin Xia. https://www.nature.com/articles/s41419-019-1481-9

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism – Giulia Guiducci, Alessio Paone, Angela Tramonti, Giorgio Giardina, Serena Rinaldo, Amani Bouzidi, Maria C Magnifico, Marina Marani, Javier A Menendez, Alessandro Fatica, Alberto Macone, Alexandros Armaos, Gian G Tartaglia, Roberto Contestabile, Alessandro Paiardini, Francesca Cutruzzolà. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz129/5365575

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner – Tanveer Sharif, Cathleen Dai, Emma Martell, Mohammad Saleh Ghassemi-Rad, Mark Robert Hanes, Patrick J. Murphy, Barry E. Kennedy, Chitra Venugopal, Minomi Subapanditha, Carman A. Giacomantonio, Paola Marcato, Sheila K. Singh and Shashi Gujar. http://clincancerres.aacrjournals.org/content/25/6/2001

IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis – Kumar S. Bishnupuri, David M. Alvarado, Alexander N. Khouri, Mark Shabsovich, Baosheng Chen, Brian K. Dieckgraefe and Matthew A. Ciorba. http://cancerres.aacrjournals.org/content/79/6/1138

Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma – Sze-Kwan Lam, Sheng Yan, Shi Xu, Kin-Pong U, Paul Ning-Man Cheng and James Chung-Man Ho. https://www.nature.com/articles/s41389-019-0128-0

Urea cycle sustains cellular energetics upon EGFR inhibition in EGFR mutant NSCLC – Catherine Pham-Danis, Sarah Gehrke, Etienne Danis, Andrii I Rozhok, Michael W Daniels, Dexiang Gao, Christina Collins, Jose T Di Paola, Angelo D’Alessandro and James DeGregori. http://mcr.aacrjournals.org/content/early/2019/02/26/1541-7786.MCR-18-1068.long

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis – Le Li, Youxiang Mao, Lina Zhao, Lijia Li, Jinjun Wu, Mengjia Zhao, Wenjing Du, Li Yu and Peng Jiang. https://www.nature.com/articles/s41586-019-0996-7


Lipid metabolism


Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death – Javier Garcia-Bermudez, Lou Baudrier, Erol Can Bayraktar, Yihui Shen, Konnor La, Rohiverth Guarecuco, Burcu Yucel, Danilo Fiore, Bernardo Tavora, Elizaveta Freinkman, Sze Ham Chan, Caroline Lewis, Wei Min, Giorgio Inghirami, David M. Sabatini and Kıvanç Birsoy. https://www.nature.com/articles/s41586-019-0945-5

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP – Patrizia Romani, Irene Brian, Giulia Santinon, Arianna Pocaterra, Matteo Audano, Silvia Pedretti, Samuel Mathieu, Mattia Forcato, Silvio Bicciato, Jean-Baptiste Manneville, Nico Mitro and Sirio Dupont. https://www.nature.com/articles/s41556-018-0270-5

Statins affect human glioblastoma and other cancers through TGF-β inhibition – Aizhen Xiao, Breanna Brenneman, Desiree Floyd, Laurey Comeau, Kelsey Spurio, Inan Olmez, Jeongwu Lee, Ichiro Nakano, Jakub Godlewski, Agnieszka Bronisz, Noritaka Kagaya, Kazuo Shin-ya and Benjamin Purow. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26733&path[]=83070

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma – Saiful E. Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A. Patel, M. Nazhif Zaini, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Tim Eisen, Dóra Bihary, Shamith A. Samarajiwa and Sakari Vanharanta. https://www.nature.com/articles/s41467-019-09116-x


Nucleotides 


Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase – Gerta Hoxhaj, Issam Ben-Sahra, Sophie E. Lockwood, Rebecca C. Timson, Vanessa Byles, Graham T. Henning, Peng Gao, Laura M. Selfors, John M. Asara, Brendan D. Manning. http://science.sciencemag.org/content/363/6431/1088

NAD+ metabolism governs the proinflammatory senescence-associated secretome – Timothy Nacarelli, Lena Lau, Takeshi Fukumoto, Joseph Zundell, Nail Fatkhutdinov, Shuai Wu, Katherine M. Aird, Osamu Iwasaki, Andrew V. Kossenkov, David Schultz, Ken-ichi Noma, Joseph A. Baur, Zachary Schug, Hsin-Yao Tang, David W. Speicher, Gregory David and Rugang Zhang. https://www.nature.com/articles/s41556-019-0287-4

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism – Li Chen, Zhaoyue Zhang, Atsushi Hoshino, Henry D. Zheng, Michael Morley, Zoltan Arany and Joshua D. Rabinowitz. https://www.nature.com/articles/s42255-019-0043-x


Mitochondria


MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism – Jiyoung Lee, Ali E. Yesilkanal, Joseph P. Wynne, Casey Frankenberger, Juan Liu, Jielin Yan, Mohamad Elbaz, Daniel C. Rabe, Felicia D. Rustandy, Payal Tiwari, Elizabeth A. Grossman, Peter C. Hart, Christie Kang, Sydney M. Sanderson, Jorge Andrade, Daniel K. Nomura, Marcelo G. Bonini, Jason W. Locasale and Marsha Rich Rosner. https://www.nature.com/articles/s41586-019-1005-x

Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin – Juan Garrido-Maraver, Ivana Celardo, Ana C. Costa, Susann Lehmann, Samantha H. Y. Loh and L. Miguel Martins. https://www.nature.com/articles/s41419-019-1496-2

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition – Alberto Cruz-Bermúdez, Raquel Laza-Briviesca, Ramiro J. Vicente-Blanco,Aránzazu García-Grande, Maria José Coronado, Sara Laine-Menéndez, Sara Palacios-Zambrano, M. Rocío Moreno-Villa, Asunción Martin Ruiz-Valdepeñas, Cristina Lendinez, Atocha Romero, Fernando Franco, Virginia Calvo, Cristina Alfaro, Paloma Martin Acosta, Clara Salas, José Miguel Garcia, Mariano Provencio. https://www.sciencedirect.com/science/article/pii/S089158491831582X

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain – Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib and Margaret Ashcroft. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0194-y

S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2 – Lili Liu, Lei Qi, Teresa Knifley, Dava W. Piecoro, Piotr Rychahou, Jinpeng Liu, Mihail I. Mitov, Jeremiah Martin, Chi Wang, Jianrong Wu, Heidi L. Weiss, D. Allan Butterfield, B. Mark Evers, Kathleen L. O’Connor and Min Chen. http://www.jbc.org/content/early/2019/03/18/jbc.RA118.004365.abstract


Cancer metabolism and epigenetics


Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis – Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney L. Campbell, Robert J. Norgard, Kollin C. Schultz, Simone Sidoli, Joshua L.D. Parris, Hayley C. Affronti, Sharanya Sivanand, Shaun Egolf, Yogev Sela, Marco Trizzino, Alessandro Gardini, Benjamin A. Garcia, Nathaniel W. Snyder, Ben Z. Stanger and Kathryn E. Wellen. http://cancerdiscovery.aacrjournals.org/content/9/3/416

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer – Miguel Reina-Campos, Juan F. Linares, Angeles Duran, Thekla Cordes, Antoine L’Hermitte, Mehmet G. Badur, Munveer S. Bhangoo, Phataraporn K. Thorson, Alicia Richards, Tarmo Rooslid, Dolores C. Garcia-Olmo, Syongh Y. Nam-Cha, Antonio S. Salinas-Sanchez, Ken Eng, Himisha Beltran, David A. Scott, Christian M. Metallo, Jorge Moscat, Maria T. Diaz-Meco. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30052-2


AMPK


Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation – Shuai Zhang, Hao Sheng, Xiaoya Zhang, Qi Qi, Chi Bun Chan, Leilei Li, Changliang Shan and Keqiang Ye. https://www.nature.com/articles/s41419-019-1452-1

AMPK is down-regulated by the CRL4A-CRBN axis through the polyubiquitination of AMPKα isoforms – Eunju Kwon, Xian Li, Yifeng Deng, Hyeun Wook Chang and Dong Young Kim. https://www.fasebj.org/doi/abs/10.1096/fj.201801766RRR

Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism – Martin Pelosse, Cécile Cottet-Rousselle, Cécile M. Bidan, Aurélie Dupont, Kapil Gupta, Imre Berger and Uwe Schlattner. https://www.nature.com/articles/s41467-019-08938-z


mTOR / GCN2


mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53 – Seung Hee Jung, Hyun Jung Hwang, Donghee Kang, Hyun A. Park, Hyung Chul Lee, Daecheol Jeong, Keunwook Lee, Heon Joo Park, Young-Gyu Ko and Jae-Seon Lee. https://www.nature.com/articles/s41388-018-0521-8

Activation of GCN2 by the ribosomal P-stalk – Alison J. Inglis, Glenn R. Masson, Sichen Shao, Olga Perisic, Stephen H. McLaughlin, Ramanujan S. Hegde and Roger L. Williams. https://www.pnas.org/content/116/11/4946.abstract?etoc


Hypoxia


Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate – Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E. Ringel, Matthew A. Booker, Michael Y. Tolstorukov, Yuzhong Jeff Meng, Samuel R. Meier, Rebecca B. Jennings, Amanda L. Creech, Zachary T. Herbert, Samuel K. McBrayer, Benjamin A. Olenchock, Jacob D. Jaffe, Marcia C. Haigis, Rameen Beroukhim, Sabina Signoretti, Peppi Koivunen, William G. Kaelin Jr. http://science.sciencemag.org/content/363/6432/1217

Hypoxia induces rapid changes to histone methylation and reprograms chromatin – Michael Batie, Julianty Frost, Mark Frost, James W. Wilson, Pieta Schofield, Sonia Rocha. http://science.sciencemag.org/content/363/6432/1222

Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis – Meixi Peng, Dan Yang, Yixuan Hou, Shuiqing Liu, Maojia Zhao, Yilu Qin, Rui Chen, Yong Teng and Manran Liu. https://www.nature.com/articles/s41419-019-1475-7

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during  hypoxia – Rafal Bartoszewski, Adrianna Moszyńska, Marcin Serocki, Aleksandra Cabaj, Andreas Polten, Renata Ochocka, Louis Dell’Italia, Sylwia Bartoszewska, Jarosław Króliczewski, Michał Dąbrowski and James F. Collawn. https://www.fasebj.org/doi/abs/10.1096/fj.201802650RR?ai=ts&ui=ly8&af=T


Miscellaneous


Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization – Harihar Basnet, Lin Tian, Karuna Ganesh, Yun-Han Huang, Danilo G Macalinao, Edi Brogi, Lydia Finley,  Joan Massagué. https://elifesciences.org/articles/43627


Reviews


Molecular logic of mTORC1 signalling as a metabolic rheostat – Alexander J. Valvezan and Brendan D. Manning. https://www.nature.com/articles/s42255-019-0038-7

Crosstalk between metabolism and circadian clocks – Hans Reinke and Gad Asher. https://www.nature.com/articles/s41580-018-0096-9

The ERK and JNK pathways in the regulation of metabolic reprogramming – Salvatore Papa, Pui Man Choy and Concetta Bubici. https://www.nature.com/articles/s41388-018-0582-8

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis – Brian W. Labadie, Riyue Bao and Jason J. Luke. http://clincancerres.aacrjournals.org/content/25/5/1462


Comments


Histone modifiers are oxygen sensors – Paolo Gallipoli, Brian J. P. Huntly. http://science.sciencemag.org/content/363/6432/1148

Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer – Xia Gao, Jason W. Locasale, Michael A. Reid. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30109-6

NAD-biosynthetic pathways regulate innate immunity – Leah K. Billingham and Navdeep S. Chandel. https://www.nature.com/articles/s41590-019-0353-x

B cell lymphoma R-CHOPped by metabolic inhibitors – Ming Yang. http://stm.sciencemag.org/content/11/485/eaax3456

Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors – Christopher J. Halbrook, Barbara S. Nelson and Costas A. Lysstiotis. http://cancerdiscovery.aacrjournals.org/content/9/3/326

Cell scientist to watch – Kivanc Birsoy. http://jcs.biologists.org/content/132/5/jcs230540?etoc

MetaboList – February 2019


Glucose metabolism, glycolytic enzymes


GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors – Johanna Chiche, Julie Reverso-Meinietti, Annabelle Mouchotte, Camila Rubio-Patiño, Rana Mhaidly, Elodie Villa, Jozef P. Bossowski, Emma Proics, Manuel Grima-Reyes, Agnès Paquet, Konstantina Fragaki, Sandrine Marchetti, Josette Briere, Damien Ambrosetti, Jean-François Michiels, Thierry Jo Molina, Christiane Copie-Bergman, Jacqueline Lehmann-Che, Isabelle Peyrottes, Frederic Peyrade, Eric de Kerviler, Bruno Taillan, Georges Garnier, Els Verhoeyen, Véronique Paquis-Flucklinger, Laetitia Shintu, Vincent Delwail, Celine Delpech-Debiais, Richard Delarue, André Bosly, Tony Petrella, Gabriel Brisou, Bertrand Nadel, Pascal Barbry, Nicolas Mounier, Catherine Thieblemont, Jean-Ehrland Ricci. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30066-X

Fasting plasma glucose is an independent predictor of survival in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy – Milana Bergamino, Antonio J. Rullan, Maria Saigí, Inmaculada Peiró, Eduard Montanya, Ramón Palmero, José Carlos Ruffinelli, Arturo Navarro, María Dolores Arnaiz, Isabel Brao, Samantha Aso, Susana Padrones, Felipe Cardenal and Ernest Nadal. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5370-5

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity – Bruno Saleme, Vikram Gurtu, Yongneng Zhang, Adam Kinnaird, Aristeidis E. Boukouris, Keshav Gopal, John R. Ussher and Gopinath Sutendra. http://stm.sciencemag.org/content/11/478/eaau8866

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 – Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale, Ziv Gil and Mei Kong. https://www.nature.com/articles/s41467-019-08759-0

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity – Bruno Saleme, Vikram Gurtu, Yongneng Zhang, Adam Kinnaird, Aristeidis E. Boukouris, Keshav Gopal, John R. Ussher and Gopinath Sutendra. http://stm.sciencemag.org/content/11/478/eaau8866

IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells – Masahiro Shimizu and Nobuyuki Tanaka. https://www.nature.com/articles/s41388-018-0533-4

Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress – Hailong Qi, Xianling Ning, Chang Yu, Xin Ji, Yan Jin,  Michael A. McNutt and Yuxin Yin. https://www.nature.com/articles/s41419-018-1271-9


Amino acid metabolism / one carbon


HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis – Florinda Meléndez-Rodríguez, Andrés A. Urrutia, Doriane Lorendeau, Gianmarco Rinaldi, Olga Roche, Nuray Böğürcü-Seidel, Marta Ortega Muelas, Claudia Mesa-Ciller, Guillermo Turiel, Antonio Bouthelier, Pablo Hernansanz-Agustín, Ainara Elorza, Elia Escasany, Qilong Oscar Yang Li, Mar Torres-Capelli, Daniel Tello, Esther Fuertes, Enrique Fraga, Antonio Martínez-Ruiz, Belen Pérez, Jose Miguel Giménez-Bachs, Antonio S. Salinas-Sánchez, Till Acker, Ricardo Sánchez Prieto, Sarah-Maria Fendt, Katrien De Bock, Julián Aragonés. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30143-3

Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation – Lauren V. Albrecht, Maggie H. Bui, and Edward M. De Robertis. https://www.pnas.org/content/116/8/2987.abstract?etoc

Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase – Irena Roci, Jeramie D. Watrous, Kim A. Lagerborg, Lorenzo Lafranchi, Arne Lindqvist, Mohit Jain, Roland Nilsson. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30088-9


Lipid metabolism


Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity – Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, João A. G. Duarte, Arndt A. Schmitz, Patrick Steigemann, Mustapha Najimi, Andrea Hägebarth, Jo A. Van Ginderachter, Etienne Sokal, Naohiro Gotoh, Kwok-Kin Wong, Catherine Verfaillie, Rita Derua, Sebastian Munck, Mariia Yuneva, Laura Beretta, Ralph J. DeBerardinis, Johannes V. Swinnen, Leanne Hodson, David Cassiman, Chris Verslype, Sven Christian, Sylvia Grünewald, Thomas G. P. Grünewald and Sarah-Maria Fendt. https://www.nature.com/articles/s41586-019-0904-1

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation – Choong-kun Lee, Seung-hwan Jeong, Cholsoon Jang, Hosung Bae, Yoo Hyung Kim, Intae Park, Sang Kyum Kim, Gou Young Koh. http://science.sciencemag.org/content/363/6427/644


Nucleotides


Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer – Christopher J. Halbrook, Corbin Pontious, Ilya Kovalenko, Laura Lapienyte, Stephan Dreyer, Ho-Joon Lee, Galloway Thurston, Yaqing Zhang, Jenny Lazarus, Peter Sajjakulnukit, Hanna S. Hong, Daniel M. Kremer, Barbara S. Nelson, Samantha Kemp, Li Zhang, David Chang, Andrew Biankin, Jiaqi Shi, Timothy L. Frankel, Howard C. Crawford, Jennifer P. Morton, Marina Pasca di Magliano, Costas A. Lyssiotis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30065-8

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression – Chunjing Bian, Chao Zhang, Tao Luo, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong and Xiaochun Yu. https://www.nature.com/articles/s41467-019-08530-5


Mitochondria


Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses – Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli and Giuseppe Gasparre. https://www.nature.com/articles/s41467-019-08839-1

Effects of cancer-associated point mutations on the structure, function, and stability of succinate dehydrogenase A – Zhi-Fa Cao, Nan Ni, Weihao Zhuang, Fei Ye, Yuehong Wu, Jieqiong Qiu, Yeqing Wu, Qing Sheng and Wen-Bin Ou. http://www.jbc.org/content/early/2019/02/06/jbc.RA118.006266.abstract

Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts – Huabo Wang, Jie Lu, Sucheta Kulkarni, Weiqi Zhang, Joanna E. Gorka, Jordan A. Mandel, Eric S. Goetzman and Edward V. Prochownik. http://www.jbc.org/content/early/2019/02/12/jbc.RA118.005200.abstract

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress – Jeffrey Knupp, Peter Arvan and Amy Chang. https://www.nature.com/articles/s41418-018-0133-4

Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypes – Paola Lunetti, Mariangela Di Giacomo, Daniele Vergara, Stefania De Domenico, Michele Maffia, Vincenzo Zara, Loredana Capobianco, Alessandra Ferramosca. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14756


Glutathione/Redox


Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity – Patrick N. McCormick, Hannah E. Greenwood, Matthias Glaser, Oliver D.K. Maddocks, Thibault Gendron, Kerstin Sander, Gayatri Gowrishankar, Aileen Hoehne, Tong Zhang, Adam J. Shuhendler, David Y. Lewis, Mathias Berndt, Norman Koglin, Mark F. Lythgoe, Sanjiv S. Gambhir, Erik Årstad and Timothy H. Witney. http://cancerres.aacrjournals.org/content/79/4/853

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer – Shawn P. Kubli, Christian Bassi, Cecilia Roux, Andrew Wakeham, Christoph Göbl, Wenjing Zhou, Soode Moghadas Jafari, Bryan Snow, Lisa Jones, Luis Palomero, Kelsie L. Thu, Luca Cassetta, Daniel Soong, Thorsten Berger, Parameswaran Ramachandran, Shakiba P. Baniasadi, Gordon Duncan, Moshit Lindzen, Yosef Yarden, Carmen Herranz, Conxi Lazaro, Mandy F. Chu, Jillian Haight, Paul Tinto, Jennifer Silvester, David W. Cescon, Anna Petit, Sven Pettersson, Jeffrey W. Pollard, Tak W. Mak, Miguel A. Pujana, Paola Cappello and Chiara Gorrini. https://www.pnas.org/content/116/9/3604.abstract?etoc


Starvation


Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration – Anabela C. Ferretti, Florencia Hidalgo, Facundo M. Tonucci, Evangelina Almada, Alejandro Pariani, María C. Larocca and Cristián Favre. https://www.nature.com/articles/s41598-019-39556-w

Analysis of autophagy activated during changes in carbon source availability in yeast cells – Ryo Iwama and Yoshinori Ohsumi. http://www.jbc.org/content/early/2019/02/12/jbc.RA118.005698.abstract

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress – Mengli Zhang, Jian Wu, Renqiang Sun, Xiaoting Tao, Xiaoxia Wang, Qi Kang, Hui Wang, Lei Zhang, Peng Liu, Jinye Zhang, Yukun Xia, Yuzheng Zhao, Yi Yang, Yue Xiong, Kun-Liang Guan, Yunzeng Zou, Dan Ye. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211796


Hypoxia


OCT4B mediates hypoxia-induced cancer dissemination – Sheng-Chieh Lin, Chi-Hsiu Chung, Chih-Hung Chung, Ming-Han Kuo, Cheng-Han Hsieh, Yu-Fan Chiu, Yi-Shing Shieh, Yu-Ting Chou and Cheng-Wen Wu. https://www.nature.com/articles/s41388-018-0487-6

Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept – Noelia Campillo, Bryan Falcones, Jordi Otero, Roser Colina, David Gozal, Daniel Navajas, Ramon Farré and Isaac Almendros. https://www.frontiersin.org/articles/10.3389/fonc.2019.00043/full

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis – Florinda Meléndez-Rodríguez, […] Julián Aragonés. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30143-3


IDH


Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib – Eytan M. Stein, Courtney D. DiNardo, Amir T. Fathi, Daniel A. Pollyea, Richard M. Stone, Jessica K. Altman, Gail J. Roboz, Manish R. Patel, Robert Collins, Ian W. Flinn, Mikkael A. Sekeres, Anthony S. Stein, Hagop M. Kantarjian, Ross L. Levine, Paresh Vyas, Kyle J. MacBeth, Alessandra Tosolini, Jason VanOostendorp, Qiang Xu, Ira Gupta, Thomas Lila, Alberto Risueno, Katharine E. Yen, Bin Wu, Eyal C. Attar, Martin S. Tallman and Stéphane de Botton. http://bloodjournal.org/content/133/7/676.abstract?etoc

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response – Felipe J. Núñez , Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri, Masha G. Savelieff, Maria B. Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Meghna Saxena, Rohin Patel, Stephen Carney, Marissa Z. Guo, Marta Edwards, Mats Ljungman, Tingting Qin, Maureen A. Sartor, Rebecca Tagett, Sriram Venneti, Jacqueline Brosnan-Cashman, Alan Meeker, Vera Gorbunova, Lili Zhao, Daniel M. Kremer, Li Zhang, Costas A. Lyssiotis, Lindsey Jones, Cameron J. Herting, James L. Ross, Dolores Hambardzumyan, Shawn Hervey-Jumper, Maria E. Figueroa, Pedro R. Lowenstein, Maria G. Castro. http://stm.sciencemag.org/content/11/479/eaaq1427


Cancer Immunometabolism


Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis – Hoibin Jeong, Sehui Kim, Beom-Ju Hong, Chan-Ju Lee, Young-Eun Kim, Seoyeon Bok, Jung-Min Oh, Seung-Hee Gwak, Min Young Yoo, Min Sun Lee, Seock-Jin Chung, Joan Defrêne, Philippe Tessier, Martin Pelletier, Hyeongrin Jeon, Tae-Young Roh, Bumju Kim, Ki Hean Kim, Ji Hyeon Ju, Sungjee Kim, Yoon-Jin Lee, Dong-Wan Kim, Il Han Kim, Hak Jae Kim, Jong-Wan Park, Yun-Sang Lee, Jae Sung Lee, Gi Jeong Cheon, Irving L. Weissman, Doo Hyun Chung, Yoon Kyung Jeon and G-One Ahn. http://cancerres.aacrjournals.org/content/79/4/795

Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma – Najjar YG, Menk AV, Sander C, Rao U, Karunamurthy A, Bhatia R, Zhai S, Kirkwood JM, Delgoffe GM. https://insight.jci.org/articles/view/124989

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses – Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli and Giuseppe Gasparre. https://www.nature.com/articles/s41467-019-08839-1


Miscellaneous


Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways – Dongya Jia, Mingyang Lu, Kwang Hwa Jung, Jun Hyoung Park, Linglin Yu, José N. Onuchic, Benny Abraham Kaipparettu and Herbert Levine. https://www.pnas.org/content/116/9/3909.abstract?etoc

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles – Truc T. Losier, Mercy Akuma, Olivia C. McKee-Muir, Nicholas D. LeBlond, Yujin Suk, Reham M. Alsaadi, Zhihao Guo, Ryan Reshke, Subash Sad, François-Xavier Campbell-Valois, Derrick J. Gibbings, Morgan D. Fullerton, Ryan C. Russell. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30091-9


Reviews


Metabolic signatures of cancer cells and stem cells – Andrew M. Intlekofer and Lydia W. S. Finley. https://www.nature.com/articles/s42255-019-0032-0

Toward a better understanding of folate metabolism in health and disease – Yuxiang Zheng and Lewis C. Cantley. http://jem.rupress.org/content/216/2/253?etoc

Nutrient regulation of signaling and transcription [by O-linked β-GlcNAc; O-GlcNAc] – Gerald W. Hart. http://www.jbc.org/content/294/7/2211.abstract.html

Dynamics and functions of lipid droplets – James A. Olzmann and Pedro Carvalho. https://www.nature.com/articles/s41580-018-0085-z

Immune control by amino acid catabolism during tumorigenesis and therapy   – Henrique Lemos, Lei Huang, George C. Prendergast and Andrew L. Mellor. https://www.nature.com/articles/s41568-019-0106-z

Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming – Custodia García-Jiménez, Colin R. Goding. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30737-X

p53 tumor suppressor and iron homeostasis – Jin Zhang, Xinbin Chen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14638


Comments


Tumours use a metabolic twist to make lipids – Marteinn Thor Snaebjornsson, Almut Schulze. https://www.nature.com/articles/d41586-019-00352-1

Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors – Chiara Gorrini, Tak W. Mak. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30051-0

Host Control of Tumor Feeding: Autophagy Holds the Key – Anthony Venida, Rushika M. Perera. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30009-9

AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth – Krushna C. Patra, Vajira K. Weerasekara, Nabeel Bardeesy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30748-4

IDH2 inhibition: another piece to the puzzle – Lars Bullinger. http://bloodjournal.org/content/133/7/625?etoc

A PET Glutamate Analogue to Measure Cancer Cell Redox State and Oxidative Stress: Promise and Paradox – Hsiaoju S. Lee, Austin R. Pantel, Rong Zhou and David A. Mankoff. http://cancerres.aacrjournals.org/content/79/4/701

Fasting in oncology: a word of caution – Riccardo Caccialanza, Giuseppe Aprile, Emanuele Cereda and Paolo Pedrazzoli. https://www.nature.com/articles/s41568-018-0098-0

Reply to ‘Fasting in oncology: a word of caution’ – Alessio Nencioni, Irene Caffa, Salvatore Cortellino and Valter D. Longo. https://www.nature.com/articles/s41568-018-0100-x

Mannose Inhibits Tumor Growth and Increases Tumor Chemosensitivity
http://cancerdiscovery.aacrjournals.org/content/9/2/OF6

WITHDRAWN: Effects of cancer-associated point mutations on the structure, function, and stability of succinate dehydrogenase A – Zhi-Fa Cao, Nan Ni, Weihao Zhuang, Fei Ye, Yuehong Wu, Jieqiong Qiu, Yeqing Wu, Qing Sheng and Wen-Bin Ou. http://www.jbc.org/content/early/2019/02/25/jbc.RA118.006266.abstract

MetaboList – January 2019


Nucleotides


Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells – Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J. https://www.sciencedirect.com/science/article/pii/S1550413118306466

AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells – Lijuan Du, Fan Yang, Houshun Fang, Huiying Sun, Yao Chen, Yan Xu, Hui Li, Liang Zheng and Bin-Bing S. Zhou. https://www.fasebj.org/doi/abs/10.1096/fj.201801559RR?ai=ts&ui=ly8&af=T


Lipids / Acetyl-CoA


Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis – Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney Campbell, Robert J Norgard, Kollin C Schultz, Simone Sidoli, Joshua L.D. Parris, Hayley C Affronti, Sharanya Sivanand, Shaun Egolf, Yogev Sela, Marco Trizzino, Alessandro Gardini, Benjamin A Garcia, Nathaniel W Snyder, Ben Z. Stanger and Kathryn Wellen. http://cancerdiscovery.aacrjournals.org/content/early/2019/01/09/2159-8290.CD-18-0567

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma – James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao, Jennifer L. Rocnik, William F. Westlin, Paola Muti, Theodoros Tsakiridis, H. James Harwood Jr., Rosana Kapeller, Yujin Hoshida, Kenneth K. Tanabe, Gregory R. Steinberg, Bryan C. Fuchs. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30521-7

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis – Vrushank Bhatt, Khoosheh Khayati, Zhixian Sherrie Hu, Amy Lee, Wali Kamran, Xiaoyang Su and Jessie Yanxiang Guo. http://genesdev.cshlp.org/content/33/3-4/150.abstract?etoc

Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells – Andy Göbel, Dorit Breining, Martina Rauner, Lorenz C. Hofbauer and Tilman D. Rachner. https://www.nature.com/articles/s41419-019-1322-x

Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor – Ji Seul Han, Jung Hyun Lee, Jinuk Kong, Yul Ji, Jiwon Kim, Sung Sik Choe  and Jae Bum Kim. http://mcb.asm.org/content/39/2/e00390-18.abstract?etoc

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer – Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D’Anello, Alfredo Csibi, Radha Kalekar, Benjamin Larimer, Leigh Ellis, Lisa M. Butler, Colm Morrissey, Karen McGovern, Vito J. Palombella, Jeffery L. Kutok, Umar Mahmood, Silvano Bosari, Julian Adams, Stephane Peluso, Scott M. Dehm, Stephen R. Plymate and Massimo Loda. https://www.pnas.org/content/116/2/631

Lipid and Glucose Metabolism in Hepatocyte Cell Lines and Primary Mouse Hepatocytes: A comprehensive resource for in vitro studies of hepatic metabolism – Shilpa R. Nagarajan , Moumita Paul-Heng , James R Krycer , Daniel Fazakerley , Alexandra F. Sharland and Andrew J. Hoy. https://www.physiology.org/doi/abs/10.1152/ajpendo.00365.2018

Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer – Seher Balaban, Zeyad D Nassar, Alison Y. Zhang, Elham Hosseini-Beheshti, Margaret M. Centenera, Mark Schreuder, Hui-Ming Lin, Atqiya Aishah, Bianca Varney, Frank Liu-Fu, Lisa S. Lee, Shilpa R. Nagarajan, Robert F. Shearer, Rae-Anne Hardie, Nikki L. Raftopulos, Meghna S. Kakani, Darren N. Saunders, Jeff Holst, Lisa G Horvath, Lisa M. Butler and Andrew J. Hoy. http://mcr.aacrjournals.org/content/early/2019/01/15/1541-7786.MCR-18-0347


Glucose metabolism, lactate


FOXK1 and FOXK2 regulate aerobic glycolysis – Valentina Sukonina, Haixia Ma, Wei Zhang, Stefano Bartesaghi, Santhilal Subhash, Mikael Heglind, Håvard Foyn, Matthias J. Betz, Daniel Nilsson, Martin E. Lidell, Jennifer Naumann, Saskia Haufs-Brusberg, Henrik Palmgren, Tanmoy Mondal, Muheeb Beg, Mark P. Jedrychowski, Kjetil Taskén, Alexander Pfeifer, Xiao-Rong Peng, Chandrasekhar Kanduri and Sven Enerbäck. https://www.nature.com/articles/s41586-019-0900-5

The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect – Qingguo Li, Ping Wei, Jitao Wu, Meng Zhang, Guichao Li, Yaqi Li, Ye Xu, Xinxiang Li, Dacheng Xie, Sanjun Cai, Keping Xie and Dawei Li. https://www.nature.com/articles/s41388-018-0469-8

Lactic Acid Accumulation in the Tumor Microenvironment Suppresses 18F-FDG Uptake – Silvan Türkcan, Louise Kiru, Dominik J. Naczynski, Laura S. Sasportas and Guillem Pratx. http://cancerres.aacrjournals.org/content/79/2/410

Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells – Sameer Agnihotri, Sheila Mansouri, Kelly Burrell, Mira Li, Yasin Mamatjan, Jeff Liu, Romina Nejad, Sushil Kumar, Shahrzad Jalali, Sanjay K. Singh, Alenoush Vartanian, Eric Xueyu Chen, Shirin Karimi, Olivia Singh, Severa Bunda, Alireza Mansouri, Kenneth D. Aldape and Gelareh Zadeh. http://clincancerres.aacrjournals.org/content/25/2/844

Tristetraprolin-mediated hexokinase 2 expression regulation contributes glycolysis in cancer cells – Dong Jun Kim, Mai-Tram Vo, Seong Hee Choi, Ji-Heon Lee, So Yeon Jeong, Chung Hwan Hong, Jong Soo Kim, Unn Hwa Lee, Hyung-Min Chung, Byung Ju Lee, Wha Ja Cho and Jeong Woo Park. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-09-0606

High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo – Ran Marciano, Manu Prasad, Tal Ievy, Sapir Tzadok , Gabriel Leprivier, Moshe Elkabets and Barak Rotblat. https://www.mdpi.com/2072-6694/11/2/156/htm

Tumoral microvesicle–activated glycometabolic reprogramming in  fibroblasts promotes the progression of oral squamous cell carcinoma – Erhui Jiang, Zhi Xu, Meng Wang, Tinglin Yan, Chunming Huang, Xiaocheng Zhou, Qing Liu, Lin Wang, Yang Chen, Hui Wang, Ke Liu, Zhe Shao and Zhenjun Shang. https://www.fasebj.org/doi/abs/10.1096/fj.201802226R?ai=ts&ui=ly8&af=T

LDHA and LDHB are dispensable for aerobic glycolysis in neuroblastoma cells while promoting their aggressiveness – Christian Beltinger. http://www.jbc.org/content/294/1/66.full.html

Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism – Jacques Pouysségur and Maša Ždralević. http://www.jbc.org/content/294/1/67.full.html


Amino acid metabolism


Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy – Thomas Bertero, William M. Oldham, Eloise M. Grasset, Isabelle Bourget, Etienne Boulter, Sabrina Pisano, Paul Hofman, Floriant Bellvert, Guerrino Meneguzzi, Dmitry V. Bulavin, Soline Estrach, Chloe C. Feral, Stephen Y. Chan, Alexandre Bozec, Cedric Gaggioli. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30577-1

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells – Angelika Bröer, Gregory Gauthier-Coles, Farid Rahimi, Michelle van Geldermalsen, Dieter Dorsch, Ansgar Wegener, Jeff Holst and Stefan Bröer. http://www.jbc.org/content/early/2019/01/11/jbc.RA118.006378.abstract

Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer – Alon Silberman, Omer Goldman, Odeya Boukobza Assayag, Adi Jacob, Shiran Rabinovich, Lital Adler, Joo Sang Lee, Rom Keshet, Alona Sarver, Julia Frug, Noa Stettner, Sivan Galai, Erez Persi, Keren Bahar Halpern, Yehudit Zaltsman-Amir, Ben Pode-Shakked, Raya Eilam, Yair Anikster, Sandesh C.S. Nagamani, Igor Ulitsky, Eytan Ruppin and Ayelet Erez. http://cancerres.aacrjournals.org/content/79/3/518


Mitochondria


Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis – Lauren P. Diebold, Hyea Jin Gil, Peng Gao, Carlos A. Martinez, Samuel E. Weinberg and Navdeep S. Chandel. https://www.nature.com/articles/s42255-018-0011-x

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer – David A. Bader, Sean M. Hartig […] Sean E. McGuire. https://www.nature.com/articles/s42255-018-0002-y

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers – Géraldine Gentric, Yann Kieffer, Virginie Mieulet, Oumou Goundiam, Claire Bonneau, Fariba Nemati, Ilse Hurbain, Graca Raposo, Tatiana Popova, Marc-Henri Stern, Valérie Lallemand-Breitenbach, Sebastian Müller, Tatiana Cañeque, Raphaël Rodriguez, Anne Vincent-Salomon, Hugues de Thé, Rodrigue Rossignol, Fatima Mechta-Grigoriou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30567-9

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance – Hirpara J, Eu JQ, Tan JKM, Wong AL, Clement MV, Kong LR, Ohi N, Tsunoda T, Qu J, Goh BC, Pervaiz S.. https://www.sciencedirect.com/science/article/pii/S2213231718310747?via%3Dihub

Tissue-specific expression and post-transcriptional regulation of the  ATPase inhibitory factor 1 (IF1) in human and mouse tissues – Pau B. Esparza-Moltó, Cristina Nuevo-Tapioles, Margarita Chamorro, Laura Nájera, Laura Torresano, Fulvio Santacatterina and José M. Cuezva. https://www.fasebj.org/doi/abs/10.1096/fj.201800756R?ai=s4&ui=ly8&af=T

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer – Yongxian Zhuang, Reynold C. Ly, Carleigh V. Frazier, Jia Yu, Sisi Qin, Xiao-Yang Fan, Matthew P. Goetz, Judy C. Boughey, Richard Weinshilboum and Liewei Wang. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0193-4


Starvation / nutrient sensing


Introns are mediators of cell response to starvation – Julie Parenteau, Laurine Maignon, Mélodie Berthoumieux, Mathieu Catala, Vanessa Gagnon and Sherif Abou Elela. https://www.nature.com/articles/s41586-018-0859-7

Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases – Kuang Shen, Max L. Valenstein, Xin Gu and David M. Sabatini. http://www.jbc.org/content/early/2019/01/16/jbc.AC119.007382.abstract

RagC phosphorylation autoregulates mTOR complex 1 – Guang Yang, Sean J Humphrey, Danielle S Murashige, Deanne Francis, Qiao‐Ping Wang, Kristen C Cooke, G Gregory Neely and David E James. http://EMBOJ.embopress.org/content/38/3/e99548?etoc

Role of Mitochondria in Ferroptosis – Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30936-5

Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction – Naren Li, Qinfang Liu, Yulan Xiong, Jianzhong Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32046-1?dgcid=raven_jbs_etoc_email


mTOR


Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A – Sung Min Son, So Jung Park, Huikyong Lee, Farah Siddiqi, Jong Eun Lee, Fiona M. Menzies, David C. Rubinsztein. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30514-X

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis – Riko Hatakeyama, Marie-Pierre Péli-Gulli, Zehan Hu, Malika Jaquenoud, Guillermo Miguel Garcia Osuna, Alessandro Sardu, Jörn Dengjel, Claudio De Virgilio. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30934-1?

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics OPEN – Zhen Chen, Caoqi Lei, Chao Wang, Nan Li, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Jong Min Choi, Sung Yun Jung, Jun Qin and Junjie Chen. https://www.nature.com/articles/s41467-018-08004-0


Hypoxia


Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor – Ji Seul Han, Jung Hyun Lee, Jinuk Kong, Yul Ji, Jiwon Kim, Sung Sik Choe and Jae Bum Kim. http://mcb.asm.org/content/39/2/e00390-18.abstract?etoc

Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival – Ernesto Cortes, Dariusz Lachowski, Benjamin Robinson, Muge Sarper, Jaakko S Teppo, Stephen D Thorpe, Tyler J Lieberthal, Kazunari Iwamoto, David A Lee, Mariko Okada‐Hatakeyama, Markku T Varjosalo and Armando E del Río Hernández. http://EMBOr.embopress.org/content/20/1/e46557?etoc

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin – James A Smythies, Min Sun, Norma Masson, Rafik Salama, Peter D Simpson, Elizabeth Murray, Viviana Neumann, Matthew E Cockman, Hani Choudhry, Peter J Ratcliffe and David R Mole. http://EMBOr.embopress.org/content/20/1/e46401?etoc

Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma – Petra Miikkulainen, Heidi Högel, Fatemeh Seyednasrollah, Krista Rantanen, Laura L. Elo and Panu M. Jaakkola. http://www.jbc.org/content/early/2019/01/07/jbc.RA118.004902.abstract

Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage – Sara Timpano, Brianna D. Guild, Erin J. Specker, Gaelan Melanson, Philip J. Medeiros, Shannon L. J. Sproul and James Uniacke. https://www.fasebj.org/doi/abs/10.1096/fj.201802279R

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia – Yuanyuan Wang, Changsen Bai, Yuxia Ruan, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang and Binghui Li. https://www.nature.com/articles/s41467-018-08033-9

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma – Xinqun Li, Yeonju Lee, Ya’an Kang, Bingbing Dai, Mayrim Rios Perez, Michael Pratt, Eugene J. Koay, Michael Kim, Rolf A. Brekken and Jason B. Fleming. https://www.nature.com/articles/s41418-018-0207-3

Molecular landmarks of tumor hypoxia across cancer types – Vinayak Bhandari, Christianne Hoey, Lydia Y. Liu, Emilie Lalonde, Jessica Ray, Julie Livingstone ,Robert Lesurf, Yu-Jia Shiah,Tina Vujcic, Xiaoyong Huang, Shadrielle M. G. Espiritu, Lawrence E. Heisler, Fouad Yousif, Vincent Huang,Takafumi N. Yamaguchi,Cindy Q. Yao, Veronica Y. Sabelnykova, Michael Fraser, Melvin L. K. Chua,Theodorus van der Kwast, Stanley K. Liu, Paul C. Boutros and Robert G. Bristow. https://www.nature.com/articles/s41588-018-0318-2


IDH


IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies – Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, Nicoletta Vitale, Elisabetta Mereu, Cecilia Bandini, Elisa Pellegrino, Verdiana Pullano, Paola Omedè, Katia Todoerti, Luciano Cascione, Valentina Audrito, Anna Riccio, Antonio Rossi, Francesco Bertoni, Silvia Deaglio, Antonino Neri, Antonio Palumbo and Roberto Piva. http://bloodjournal.org/content/133/2/156.abstract?etoc

Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas – Dusten Unruh, Snezana Mirkov, Brian Wray, Michael Drumm, Jonathan Lamano, Yuping D. Li, Qazi F. Haider, Rodrigo Javier, Kathleen McCortney, Amanda Saratsis, Denise M. Scholtens, Jann N. Sarkaria, C. David James and Craig Horbinski. http://clincancerres.aacrjournals.org/content/25/2/747


Cancer Immunometabolism


Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle – Wan-Chen Cheng, Yao-Chen Tsui, Simone Ragusa, Viktor H. Koelzer, Marco Mina, Fabien Franco, Heinz Läubli, Benjamin Tschumi, Daniel Speiser, Pedro Romero, Alfred Zippelius, Tatiana V. Petrova, Kirsten Mertz, Giovanni Ciriello and Ping-Chih Ho. https://www.nature.com/articles/s41590-018-0290-0

Mitochondrial complex III is essential for suppressive function of regulatory T cells – Samuel E. Weinberg, Benjamin D. Singer, Elizabeth M. Steinert, Carlos A. Martinez, Manan M. Mehta, Inmaculada Martínez-Reyes, Peng Gao, Kathryn A. Helmin, Hiam Abdala-Valencia, Laura A. Sena, Paul T. Schumacker, Laurence A. Turka and Navdeep S. Chandel. https://www.nature.com/articles/s41586-018-0846-z

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma – Livingstone Fultang, Laura D. Gamble, Luciana Gneo, Andrea M. Berry, Sharon A. Egan, Fenna De Bie, Orli Yogev, Georgina L. Eden, Sarah Booth, Samantha Brownhill, Ashley Vardon, Carmel M. McConville, Paul N. Cheng, Murray D. Norris, Heather C. Etchevers, Jayne Murray, David S. Ziegler, Louis Chesler, Ronny Schmidt, Susan A. Burchill, Michelle Haber, Carmela De Santo and Francis Mussai. http://cancerres.aacrjournals.org/content/79/3/611


Miscellaneous


NCOA4 Maintains Murine Erythropoiesis Via Cell Autonomous And Non-Autonomous Mechanisms – Naiara Santana-Codina, Sebastian Gableske, Maria Quiles del Rey, Beata Małachowska, Mark P. Jedrychowsk, Douglas E. Biancur, Paul J. Schmidt, Mark D. Fleming, Wojciech Fendler, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias. http://www.haematologica.org/content/early/2019/01/07/haematol.2018.204123

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism – Ahmed Alshawi and Loranne Agius. http://www.jbc.org/content/early/2018/12/27/jbc.RA118.006670.abstract

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons – Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale Jr., Yueh-Ming Loo, Andrew Oberst. https://www.cell.com/immunity/fulltext/S1074-7613(18)30525-9

Antagonism of Glycolysis and Reductive Carboxylation of Glutamine Potentiates Activity of Oncolytic Adenoviruses in Cancer Cells – Arthur Dyer, Benjamin Schoeps, Sally Frost, Philip Jakeman, Eleanor M. Scott, Joshua Freedman, Egon J. Jacobus and Leonard W. Seymour. http://cancerres.aacrjournals.org/content/79/2/331

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis – Susanne Pfeiler, Manovriti Thakur, Petra Grünauer, Remco T. A. Megens, Urjita Joshi, Raffaele Coletti, Verena Samara, Geraldine Müller-Stoy, Hellen Ishikawa-Ankerhold, Konstantin Stark, Andreas Klingl, Thomas Fröhlich, Georg J. Arnold, Sonja Wörmann, Christiane J. Bruns, Hana Algül, Christian Weber, Steffen Massberg and Bernd Engelmann. https://www.fasebj.org/doi/abs/10.1096/fj.201800985R


Reviews


Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase – Zhanyu Wang, Chenfang Don. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30256-5

Lactate: A Metabolic Driver in the Tumour Landscape – Luigi Ippolito, Andrea Morandi, Elisa Giannoni, Paola Chiarugi. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30227-5

p62/SQSTM1: ‘Jack of all trades’ in health and cancer – Pablo Sánchez‐Martín, Tetsuya Saito, Masaaki Komatsu. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14712

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity – Emily R. Watts, Sarah R. Walmsley. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30202-8

Coupling Krebs cycle metabolites to signalling in immunity and cancer – Dylan G. Ryan, Michael P. Murphy […] Evanna L. Mills. https://www.nature.com/articles/s42255-018-0014-7

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer – Mei Yi, Yuanyuan Ban, Yixin Tan, Wei Xiong, Guiyuan Li, Bo Xiang. https://www.sciencedirect.com/science/article/pii/S2212877818310342


Comments


The next decade of metabolism – Fredrik Bäckhed, Elisabetta Bugianesi, Heather Christofk, Ivan Dikic, Rana Gupta, William B. Mair, Luke A. J. O’Neill, Markus Ralser, David M. Sabatini and Matthias Tschöp. https://www.nature.com/articles/s42255-018-0022-7

Glucose-Regulated TET2 Activity Links Cancer to Diabetes – Hari R. Singh, Stefan H. Stricker. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30239-5

Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again! – Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31100-6

METABOLISM – Sabotaging the host – Maria Giuseppina Baratta. https://www.nature.com/articles/s41568-018-0078-4

mTORC1 goes sensorlesshttp://stke.sciencemag.org/content/12/564/eaaw6411

Autophagy Sustains Tumors by Maintaining Serum Arginine Levelshttp://cancerdiscovery.aacrjournals.org/content/9/1/15.1

Maintaining the tumour’s diet – Ulrike Harjes. https://www-nature-com.sire.ub.edu/articles/s41568-018-0097-1?

2nd Cell Death, Cell Stress and Metabolism Conference
27 May 2019 – 30 May 2019. https://www.fusion-conferences.com/conference94.php

Metabolism in Health and Disease Conference
24 May 2019 – 27 May 2019. https://www.fusion-conferences.com/conference90.php

MetaboList – December 2018


Amino acid metabolism


Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism – Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai and Jason W. Locasale. https://www.nature.com/articles/s41467-018-07868-6

Methionine coordinates a hierarchically organized anabolic program enabling proliferation – Adhish S. Walvekar, Rajalakshmi Srinivasan, Ritu Gupta and Sunil Laxman. https://www.molbiolcell.org/doi/10.1091/mbc.E18-08-0515?ai=s5&ui=2oy6&af=T

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant – Timothy J. Humpton, Andreas K. Hock, Oliver D. K. Maddocks and Karen H. Vousden. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0191-6

Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM – Justyna Magdalena Przystal, Nabil Hajji, Combiz Khozoie, Alexander Renziehausen, Qingyu Zeng, Fernando Abaitua, Amin Hajitou, Keittisak Suwan, Elizabeth Want, John Bomalaski, Peter Szlosarek, Kevin O’Neill, Tim Crook and Nelofer Syed. https://www.nature.com/articles/s41419-018-1195-4


Lipid metabolism


p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression – Sung-Hwan Moon, Chun-Hao Huang, Shauna L. Houlihan, Kausik Regunath, William A. Freed-Pastor, John P. Morris IV, Darjus F. Tschaharganeh, Edward R. Kastenhuber, Anthony M. Barsotti, Rachel Culp-Hill, Wen Xue, Yu-Jui Ho, Timour Baslan, Xiang Li, Allison Mayle, Elisa de Stanchina, Lars Zender, David R. Tong, Angelo D’Alessandro, Scott W. Lowe, Carol Prives. https://www.cell.com/cell/fulltext/S0092-8674(18)31503-4#%20

CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis – Lucy Penfold, Angela Woods, Phillip Muckett, Alexander Yu. Nikitin, Tera R. Kent, Shuai Zhang, Rebecca Graham, Alice Pollard and David Carling. http://cancerres.aacrjournals.org/content/78/24/6747

PPARγ is dispensable for clear cell renal cell carcinoma progression – Danielle J.Sanchez, David J.Steger, NicolasSkuli, AnkitaBansal, CelesteSimon. https://www.sciencedirect.com/science/article/pii/S2212877818304393


Nucleotides


Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria – Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang and Stephen J. Benkovic. https://www.pnas.org/content/115/51/13009?etoc=

SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H)pools in cancer cells – Giovanna Sociali, Alessia Grozio, Irene Caffa, Susanne Schuster,  Pamela Becherini, Patrizia Damonte, Laura Sturla, Chiara Fresia, Mario Passalacqua, Francesca Mazzola, Nadia Raffaelli, Antje Garten, Wieland Kiess, Michele Cea, Alessio Nencioni and Santina Bruzzone. https://www.fasebj.org/doi/abs/10.1096/fj.201800321R?ai=ts&ui=ly8&af=T

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism – Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai and Jason W. Locasale. https://www.nature.com/articles/s41467-018-07868-6


Mitochondria


MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo – Erol C. Bayraktar, Lou Baudrier, Ceren Özerdem, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Andrew L. Cangelosi, David M. Sabatini, Kıvanç Birsoy, and Walter W. Chen. https://www.pnas.org/content/116/1/303?etoc=

CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis – Weilin Li, Chi Chun Wong, Xiaoming Zhang, Wei Kang, Geicho Nakatsu et al. https://www.nature.com/articles/s41388-018-0402-1

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity – Caroline Giessner, Virginie Millet, Konrad J Mostert, Thomas Gensollen, Thien-Phong Vu Manh, Marc Garibal, Binta Dieme, Noudjoud Attaf-Bouabdallah, Lionel Chasson, Nicolas Brouilly, Caroline Laprie, Tom Lesluyes, Jean Yves Blay, Laetitia Shintu, Jean Charles Martin, Erick Strauss  Correspondence email, Franck Galland,Philippe Naquet. http://www.life-science-alliance.org/content/1/4/e201800073


Glucose metabolism / lactate


2‐Deoxy‐D‐glucose has distinct and cell line‐specific effects on the survival of different cancer cells upon antitumor drug treatment – Polina Maximchik, Alibek Abdrakhmanov, Evgeniya Inozemtseva, Pyotr A. Tyurin‐Kuzmin, Boris Zhivotovsky, Vladimir Gogvadze. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14687

Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells – Xiangfeng Niu, Ying-Jr Chen, Peter A. Crawford and Gary J. Patti. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0192-5

A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation – Sasaoka N, Imamura H, Kakizuka A. https://www.sciencedirect.com/science/article/pii/S2589004218302256?via%3Dihub

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells – Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31806-0


Starvation


ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation – Ki Eun Pyo, Chang Rok Kim, Minkyoung Lee, Jong-Seo Kim, Keun Il Kim, Sung Hee Baek. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31805-9

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing – Julia Sanchez-Garrido, Vanessa Sancho-Shimizu, and Avinash R. Shenoy. http://stke.sciencemag.org/content/11/559/eaat6903

Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis – Wei‐Wei Yan, Yun‐Liu Liang, Qi‐Xiang Zhang, Di Wang, Ming‐Zhu Lei, Jia Qu, Xiang‐Huo He, Qun‐Ying Lei and Yi‐Ping Wang. http://embor.embopress.org/content/19/12/e46377?etoc

GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation – Qingcai Meng, Jin Xu, Chen Liang, Jiang Liu, Jie Hua, Yiyin Zhang, Quanxing Ni, Si Shi and Xianjun Yu. https://www.nature.com/articles/s41419-018-1244-z


Metformin


Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides – Laura Hulea, Simon-Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Young Kyuen Im, Camille Lehuédé, Eric H. Ma, Matthew Leibovitch, Shannon McLaughlan, Marie-José Blouin, Maxime Parisotto, Vasilios Papavasiliou, Cynthia Lavoie, Ola Larsson, Michael Ohh, Tiago Ferreira, Celia Greenwood, Gaëlle Bridon, Daina Avizonis, Gerardo Ferbeyre, Peter Siegel, Russell G. Jones, William Muller, Josie Ursini-Siegel, Julie St-Pierre, Michael Pollak, Ivan Topisirovic. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30566-7

A phase 2 trial of neoadjuvant metformin in combination with trastuzumab and chemotherapy in women with early HER2-positive breast cancer: the METTEN study – Martin-Castillo B, Pernas S, Dorca J, Álvarez I, Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M, Stradella A, Morilla I, Viñas G, Cortés J, Cuyàs E, Verdura S, Fernández-Ochoa Á, Fernández-Arroyo S, Segura-Carretero A, Joven J, Pérez E, Bosch N, Garcia M, López-Bonet E, Saidani S, Buxó M, Menendez JA. http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=26286

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals – Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J. https://www.ncbi.nlm.nih.gov/pubmed/30545422


Cancer immunometabolism


Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy – Ashley Orillion, Nur P. Damayanti, Li Shen, Remi Adelaiye-Ogala, Hayley Affronti, May Elbanna, Sreenivasulu Chintala, Michael Ciesielski, Luigi Fontana, Chinghai Kao, Bennett D. Elzey, Timothy L. Ratliff, David E. Nelson, Dominic Smiraglia, Scott I. Abrams and Roberto Pili. http://clincancerres.aacrjournals.org/content/24/24/6383

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression – Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum and Daniel W. McVicar. https://www.nature.com/articles/s41467-018-07505-2

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism – Marc O. Johnson, Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, Maria V. Liberti, Katelyn Paz, Rigel J. Kishton, Matthew E. Johnson, Aguirre A. de Cubas, Pingsheng Wu, Gongbo Li, Yongliang Zhang, Dawn C. Newcomb, Andrew D. Wells, Nicholas P. Restifo, W. Kimryn Rathmell, Jason W. Locasale, Marco L. Davila, Bruce R. Blazar, Jeffrey C. Rathmell. https://www.cell.com/cell/fulltext/S0092-8674(18)31309-6?dgcid=raven_jbs_etoc_email


Liver cancer


An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma – Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T. S. Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W. H. Chan, Joanna H. Tong, Yue-Sun Cheung, Paul B. S. Lai, Hector K. S. Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong and Alfred S. L. Cheng. https://www.nature.com/articles/s41467-018-07402-8

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes – Gholamreza Bidkhori, Rui Benfeitas, Martina Klevstig, Cheng Zhang, Jens Nielsen, Mathias Uhlen, Jan Boren and Adil Mardinoglu. https://www.pnas.org/content/115/50/E11874?etoc=

Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma – Nwosu ZC, Megger DA, Hammad S, Sitek B, Roessler S, Ebert MP, Meyer C, Dooley S. https://www.cmghjournal.org/article/S2352-345X(17)30086-3/fulltext

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours – Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA, Dooley S. https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0872-6

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression – Sung-Hwan Moon, Chun-Hao Huang, Shauna L. Houlihan, Kausik Regunath, William A. Freed-Pastor, John P. Morris IV, Darjus F. Tschaharganeh, Edward R. Kastenhuber, Anthony M. Barsotti, Rachel Culp-Hill, Wen Xue, Yu-Jui Ho, Timour Baslan, Xiang Li, Allison Mayle, Elisa de Stanchina, Lars Zender, David R. Tong, Angelo D’Alessandro, Scott W. Lowe, Carol Prives. https://www.cell.com/cell/fulltext/S0092-8674(18)31503-4#%20


Miscellaneous


Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30509-6

Spatially resolved metabolomics to discover tumor-associated metabolic alterations – Chenglong Sun, Tiegang Li, Xiaowei Song, Luojiao Huang, Qingce Zang, Jing Xu, Nan Bi, Guanggen Jiao, Yanzeng Hao, Yanhua Chen, Ruiping Zhang, Zhigang Luo, Xin Li, Luhua Wang, Zhonghua Wang, Yongmei Song, Jiuming He and Zeper Abliz. https://www.pnas.org/content/116/1/52?etoc=

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD – Daniel Garcia, Kristina Hellberg, Amandine Chaix, Martina Wallace, Sébastien Herzig, Mehmet G. Badur, Terry Lin, Maxim N. Shokhirev, Antonio F.M. Pinto, Debbie S. Ross, Alan Saghatelian, Satchidananda Panda, Lukas E. Dow, Christian M. Metallo, Reuben J. Shaw. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31966-1

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal – Michalis Mastri, Amanda Tracz, Christina R. Lee, Melissa Dolan, Kristopher Attwood, James G. Christensen, Song Liu, John M.L. Ebos. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31928-4


Reviews


Metabolic Reprogramming of Non-Hodgkin’s B-Cell Lymphomas and Potential Therapeutic Strategies – Jean-Ehrland Ricci and Johanna Chiche. https://www.frontiersin.org/articles/10.3389/fonc.2018.00556/full

The lysosome as a cellular centre for signalling, metabolism and quality control – Rosalie E. Lawrence and Roberto Zoncu. https://www.nature.com/articles/s41556-018-0244-7

mTOR as a central hub of nutrient signalling and cell growth – Joungmok Kim and Kun-Liang Guan. https://www.nature.com/articles/s41556-018-0205-1

The emerging link between cancer, metabolism, and circadian rhythms – Selma Masri and Paolo Sassone-Corsi. https://www.nature.com/articles/s41591-018-0271-8

NAD Metabolism in Cancer Therapeutics – Keisuke Yaku, Keisuke Okabe, Keisuke Hikosaka and Takashi Nakagawa. https://www.frontiersin.org/articles/10.3389/fonc.2018.00622/full


Comments


HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth – Issam Ben-Sahra, Alexandre Puissant. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30686-7

Probing mitochondrial metabolism in vivo – Gregory S. McElroy and Navdeep S. Chandel. https://www.pnas.org/content/116/1/20?etoc=

Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism – Julie Leca, Thorsten Berger, Tak Wah Mak. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30688-0

New developments of Metformin in the clinical cancer area – Lev M. Berstein. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=3043c292d9&e=923b339f12

MetaboList – November 2018

Subscribe here: http://eepurl.com/cvQCw9


Glucose metabolism / lactate


Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma – Claudio R. Scafoglio , Brendon Villegas, Gihad Abdelhady, Sean T. Bailey, Jie Liu, Aditya S. Shirali, W. Dean Wallace, Clara E. Magyar, Tristan R. Grogan, David Elashoff, Tonya Walser, Jane Yanagawa, Denise R. Aberle, Jorge R. Barrio, Steven M. Dubinett, David B. Shackelford. http://stm.sciencemag.org/content/10/467/eaat5933

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo – Kevin D. Courtney, Divya Bezwada, Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Alexander M. Funk, Jennifer Wimberly, Sarah S. McNeil, Payal Kapur, Yair Lotan, Vitaly Margulis, Jeffrey A. Cadeddu, Ivan Pedrosa, Ralph J. DeBerardinis, Craig R. Malloy, Robert M. Bachoo, Elizabeth A. Maher. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30463-7

Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of GLUT1-mediated sugar uptake – Ogooluwa A Ojelabi, Kenneth P Lloyd, Julie K De Zutter and Anthony Carruthers. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.002326.abstract

Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking – Guang-Zhi Jin, Yajuan Zhang, Wen-Ming Cong, Xueyuan Wu, Xiongjun Wang, Siyang Wu, Siyao Wang, Weiping Zhou, Shengxian Yuan, Hong Gao, Guanzhen Yu, Weiwei Yang. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006483

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer – Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang et al. https://www.nature.com/articles/s41388-018-0386-x

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis – Kekoa Taparra, Hailun Wang, Reem Malek, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken Kang-Hsin Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara and Phuoc T. Tran. https://www.jci.org/articles/view/94844

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth – Andrew G Cox, Allison Tsomides, Dean Yimlamai, Katie L Hwang, Joel Miesfeld, Giorgio G Galli, Brendan H Fowl, Michael Fort, Kimberly Y Ma, Mark R Sullivan, Aaron M Hosios, Erin Snay, Min Yuan, Kristin K Brown, Evan C Lien, Sagar Chhangawala, Matthew L Steinhauser, John M Asara, Yariv Houvras, Brian Link, Matthew G Vander Heiden, Fernando D Camargo and Wolfram Goessling. http://EMBOJ.embopress.org/content/37/22/e100294?etoc

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation – Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang and Peng Jiang. https://www.nature.com/articles/s41467-018-07127-8

Antagonism of glycolysis and reductive carboxylation of glutamine potentiates activity of oncolytic adenoviruses in cancer cells – Arthur Dyer, Benjamin Schoeps, Sally Frost, Philip G Jakeman, Eleanor M Scott, Joshua Freedman and Leonard W. Seymour. http://cancerres.aacrjournals.org/content/early/2018/11/13/0008-5472.CAN-18-1326

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism – Barrett L. Updegraff, Xiaorong Zhou, Yabin Guo, Mahesh S. Padanad, Pei-Hsuan Chen, Chendong Yang, Jessica Sudderth, Carla Rodriguez-Tirado, Luc Girard, John D. Minna, Prashant Mishra, Ralph J. DeBerardinis, Kathryn A. O’Donnell. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31722-4

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis – Carmen Dorneburg, Matthias Fischer, Thomas F.E. Barth, Wolfgang Mueller-Klieser, Barbara Hero, Judith Gecht, Daniel R. Carter, Katleen de Preter, Benjamin Mayer, Lisa Christner, Frank Speleman, Glenn M. Marshall, Klaus-Michael Debatin and Christian Beltinger. http://clincancerres.aacrjournals.org/content/24/22/5772


Amino acid metabolism


Autophagy maintains tumour growth through circulating arginine – Laura Poillet-Perez, Xiaoqi Xie, Le Zhan, Yang Yang, Daniel W. Sharp, Zhixian Sherrie Hu, Xiaoyang Su, Anurag Maganti, Cherry Jiang, Wenyun Lu, Haiyan Zheng, Marcus W. Bosenberg, Janice M. Mehnert, Jessie Yanxiang Guo, Edmund Lattime, Joshua D. Rabinowitz and Eileen White. https://www.nature.com/articles/s41586-018-0697-7

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 – Mylène Tajan, Andreas K. Hock, Julianna Blagih, Neil A. Robertson, Christiaan F. Labuschagne, Flore Kruiswijk, Timothy J. Humpton, Peter D. Adams, Karen H. Vousden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30448-0

IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation – Mari B. Ishak Gabra, Ying Yang, Xazmin H. Lowman, Michael A. Reid, Thai Q. Tran and Mei Kong. https://www.nature.com/articles/s41389-018-0104-0

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting – H. Furkan Alkan, Katharina E. Walter, Alba Luengo, Corina T. Madreiter-Sokolowski, Sarah Stryeck, Allison N. Lau, Wael Al-Zoughbi, Caroline A. Lewis, Craig J. Thomas, Gerald Hoefler, Wolfgang F. Graier, Tobias Madl, Matthew G. Vander Heiden, Juliane G. Bogner-Strauss. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30464-9

Methionine coordinates a hierarchically organized anabolic program enabling proliferation – Adhish S. Walvekar, Rajalakshmi Srinivasan, Ritu Gupta and Sunil Laxman. https://www.molbiolcell.org/doi/10.1091/mbc.E18-08-0515?ai=25zg&ui=2oy6&af=T

Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma – Chiaki T. Ishida, Yiru Zhang, Elena Bianchetti, Chang Shu, Trang T.T. Nguyen, Giulio Kleiner, Maria J. Sanchez-Quintero, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Varun V. Prabhu, Joshua E. Allen and Markus D. Siegelin. http://clincancerres.aacrjournals.org/content/24/21/5392

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9


Lipid metabolism


CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis – Ying-nan Wang, Zhao-lei Zeng, Jiahuan Lu, Yun Wang, Ze-xian Liu, Ming-ming He, Qi Zhao, Zi-xian Wang, Ting Li, Yun-xin Lu, Qi-nian Wu, Kai Yu, Feng Wang, Heng-Ying Pu, Bo Li, Wei-hua Jia, Ming shi, Dan Xie, Tie-bang Kang, Peng Huang, Huai-qiang Ju and Rui-hua Xu. https://www.nature.com/articles/s41388-018-0384-z

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer – Anju Singh, Christian Ruiz, Kavita Bhalla, John A. Haley, Qing Kay Li, George Acquaah-Mensah, Emily Montal, Kuladeep R. Sudini, Ferdinandos Skoulidis, Ignacio I. Wistuba, Vassiliki Papadimitrakopoulou, John V. Heymach, Laszlo G. Boros, Edward Gabrielson, Julian Carretero, Kwok-Kin Wong, John D. Haley, Shyam Biswal and Geoffrey D. Girnun. https://www.fasebj.org/doi/abs/10.1096/fj.201800204?ai=s4&ui=ly8&af=T


Nucleotides


Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis – Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying and Alec C. Kimmelman. https://www.nature.com/articles/s41467-018-07472-8?

Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR [yeast] – Delphine C Douillet, Benoît Pinson, Johanna Ceschin, Hans C Hürlimann, Christelle Saint-Marc, Damien Laporte, Stéphane Claverol, Manfred Konrad, Marc Bonneu and Bertrand Daignan-Fornier. http://www.jbc.org/content/early/2018/11/26/jbc.RA118.004964.abstract


Mitochondria


Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells – Yuxiang Zheng, Ting-Yu Lin, Gina Lee, Marcia N. Paddock, Jessica Momb, Zhe Cheng, Qian Li, Dennis L. Fei, Benjamin D. Stein, Shivan Ramsamooj, Guoan Zhang, John Blenis, Lewis C. Cantley. https://www.cell.com/cell/fulltext/S0092-8674(18)31253-4

Tissue-specific kinase expression and activity regulates flux through the pyruvate dehydrogenase complex – Alla Klyuyeva, Alina Tuganova, Natalia Y. Kedishvili and Kirill M Popov. http://www.jbc.org/content/early/2018/11/27/jbc.RA118.006433.abstract


AMPK


The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance – Fei Han, Chien-Feng Li, Zhen Cai, Xian Zhang, Guoxiang Jin, Wei-Na Zhang, Chuan Xu, Chi-Yun Wang, John Morrow, Shuxing Zhang, Dazhi Xu, Guihua Wang and Hui-Kuan Lin. https://www.nature.com/articles/s41467-018-07188-9

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation – Anoop Singh Chauhan, Xiaoguang Liu, Ji Jing, Hyemin Lee, Raj Kumar Yadav, Jindou Liu, Yubin Zhou and Boyi Gan. https://www.fasebj.org/doi/abs/10.1096/fj.201801225R?ai=ts&ui=ly8&af=T

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states – Yan Yan, X. Edward Zhou, Scott J Novick, Simon J. Shaw, Yingwu Li, Joseph S. Brunzelle, Yasumichi Hitoshi, Patrick R. Griffin, H. Eric Xu and Karsten Melcher. http://www.jbc.org/content/early/2018/11/26/jbc.RA118.004883.abstract


Nutrient sensing / starvation


A C9orf72–CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress – Yang Liu, Tao Wang, Yon Ju Ji, Kenji Johnson, Honghe Liu, Kaitlin Johnson, Scott Bailey, Yongwon Suk, Yu-Ning Lu, Mingming Liu and Jiou Wang. http://genesdev.cshlp.org/content/32/21-22/1380.abstract?etoc

Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5 – Meng Shi, Bing Chen, Divyanshu Mahajan, Boon Kim Boh, Yan Zhou, Bamaprasad Dutta, Hieng Chiong Tie, Siu Kwan Sze, Geng Wu and Lei Lu. https://www.nature.com/articles/s41467-018-07444-y


Hypoxia and HIF


p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression – Ivano Amelio, Mara Mancini, Varvara Petrova, Rob A. Cairns, Polina Vikhreva, Sara Nicolai, Alberto Marini, Alexey A. Antonov, John Le Quesne, Juvenal D. Baena Acevedo, Kate Dudek, Gabriella Sozzi, Ugo Pastorino, Richard A. Knight, Tak W. Mak and Gerry Melino. http://www.pnas.org/content/early/2018/10/29/1808314115

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription – Shi-jiang Deng, Heng-yu Chen, Zeng Ye, Shi-chang Deng, Shuai Zhu Zhu Zeng, Chi He, Ming-liang Liu, Kang Huang, Jian-xin Zhong, Feng-yu Xu, Qiang Li, Yang Liu, Chun-you Wang and Gang Zhao. https://www.nature.com/articles/s41388-018-0382-1

Notch signaling promotes a HIF2a-driven hypoxic response in multiple tumor cell types – Anders P. Mutvei, Sebastian K.-J. Landor, Rhys Fox, Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Cecilia Sahlgren, Johan Hartman, Jonas Bergh, Shaobo Jin and Urban Lendahl. https://www.nature.com/articles/s41388-018-0400-3

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy – Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap and David Z. Qian. https://www.nature.com/articles/s41467-018-07411-7?


IDH


Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate – Joseph P. Dexter, Patrick S. Ward, Tathagata Dasgupta, Aaron M. Hosios, Jeremy Gunawardena and Matthew G. Vander Heiden. http://www.jbc.org/content/early/2018/10/31/jbc.RA118.004278.abstract

D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells – Lingjun Zhang, Mia D. Sorensen, Bjarne W. Kristensen, Guido Reifenberger, Thomas M. McIntyre and Feng Lin. http://clincancerres.aacrjournals.org/content/24/21/5381

Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition – James J. Harding, Maeve A. Lowery, Alan H. Shih, Juan Schvartzman, Shengqi Hou, Christopher Famulare, Minal Patel, Mikhail Roshal, Richard K. Do, Ahmet Zehir, Daoqi You, S. Duygu Selcuklu, Agnes Viale, Martin S. Tallman, David M. Hyman, Ed Reznik, Lydia W.S. Finley, Elli Papaemmanuil, Alessandra Tosolini, Mark G. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, Sung Choe, Bin Wu, Yelena Y. Janjigian, Ingo K. Mellinghoff, Luis A. Diaz, Ross L. Levine, Ghassan K. Abou-Alfa, Eytan M. Stein and Andrew M. Intlekofer. http://cancerdiscovery.aacrjournals.org/content/8/12/1540


Metformin


Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration – Qiuli Liu, Dali Tong, Gaolei Liu, Jie Gao, Lin-ang Wang, Jing Xu, Xingxia Yang, Qiubo Xie, Yiqiang Huang, Jian Pang, Luofu Wang, Yong He, Dianzheng Zhang, Qiang Ma, Weihua Lan and Jun Jiang. http://clincancerres.aacrjournals.org/content/24/22/5622

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer – Simon R. Lord, Wei-Chen Cheng, Dan Liu, Edoardo Gaude, Syed Haider, Tom Metcalf, Neel Patel, Eugene J. Teoh, Fergus Gleeson, Kevin Bradley, Simon Wigfield, Christos Zois, Daniel R. McGowan, Mei-Lin Ah-See, Alastair M. Thompson, Anand Sharma, Luc Bidaut, Michael Pollak, Pankaj G. Roy, Fredrik Karpe, Tim James, Ruth English, Rosie F. Adams, Leticia Campo, Lisa Ayers, Cameron Snell, Ioannis Roxanis, Christian Frezza, John D. Fenwick, Francesca M. Buffa, Adrian L. Harris. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30522-9


Cancer immunometabolism


Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages – Toszka Bohn, Steffen Rapp, Natascha Luther, Matthias Klein, Till-Julius Bruehl Nobuhiko Kojima, Pamela Aranda Lopez, JennifeHahlbrock, Sabine Muth, Shogo Endo, Stefanie Pektor, Almut Brand, Kathrin Renner, Vanessa Popp, Katharina Gerlach, Dennis Vogel, Christina Lueckel, Danielle Arnold-Schild, Jacques Pouyssegur, Marina Kreutz, Magdalena Huber, Jochem Koenig, Benno Weigmann, Hans-Christian Probst, Esther von Stebut, Christian Becker, Hansjoerg Schild, Edgar Schmitt and Tobias Bopp. https://www.nature.com/articles/s41590-018-0226-8

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses – Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay and Lydia Lynch. https://www.nature.com/articles/s41590-018-0251-7


Exercise, obesity


Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade – Ziming Wang, Ethan G. Aguilar, […] Arta M. Monjazeb. https://www.nature.com/articles/s41591-018-0221-5

Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice – Jonathan Tucci, Waseem Alhushki, Ting Chen, Xia Sheng, Yong-Mi Kim and Steven D. Mittelman. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0189-0

Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer – Min Lu, Sydney M Sanderson, Amelia Zessin, Kathleen A Ashcraft, Lee W Jones, Mark W Dewhirst, Jason W Locasale and David S Hsu. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0190-7

Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development – Jiaqing Hao, Yuwen Zhang, Xiaofang Yan, Fei Yan, Yanwen Sun, Jun Zeng, Sabine Waigel, Yanhui Yin, Mostafa M. Fraig, Nejat K. Egilmez, Jill Suttles, Maiying Kong, Shujun Liu, Margot P. Cleary, Edward Sauter, Bing Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30449-2


Miscellaneous


Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape – Cankut Cubuk, Marta R. Hidalgo, Alicia Amadoz, Miguel A. Pujana, Francesca Mateo, Carmen Herranz, Jose Carbonell-Caballero and Joaquin Dopazo. http://cancerres.aacrjournals.org/content/78/21/6059

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer – Detu Zhu, Zuxianglan Zhao, Guimei Cui, Shiehong Chang, Lingling Hu, Yi Xiang See, Michelle Gek Liang Lim, Dajiang Guo, Xin Chen, Paul Robson, Yumei Luo, Edwin Cheung . https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31714-5

Thermodynamic constraints on the regulation of metabolic fluxes – Ziwei Dai and Jason W. Locasale. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.004372.abstract


Reviews


mTOR signalling and cellular metabolism are mutual determinants in cancer – Dirk Mossmann, Sujin Park and Michael N. Hall. https://www-nature-com.sire.ub.edu/articles/s41568-018-0074-8

Cancer Cachexia: More Than Skeletal Muscle Wasting – Søren Fisker Schmidt, Maria Rohm, Stephan Herzig, Mauricio Berriel Diaz. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30219-X

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

Chemical biology probes of mammalian GLUT structure and function – Geoffrey D. Holman. http://www.biochemj.org/content/475/22/3511?etoc


Comments/other


Revisiting the Warburg Effect: Some Tumors Hold Their Breath – Sydney M. Sanderson, Jason W. Locasale. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30643-0

Tumors sweeten macrophages with acids – Hiroki Sekine, Masayuki Yamamoto and Hozumi Motohashi. https://www.nature.com/articles/s41590-018-0258-0

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation – Hallvard L. Olsvik, Steingrim Svenning, Yakubu Princely Abudu, Andreas Brech, Harald Stenmark, Terje Johansen and Jakob Mejlvang. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1532265

Metabolic Flexibility in Leukemia—Adapt or Die – Boaz Nachmias, Aaron D. Schimmer. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30478-1

Obesity gives unexpected boost to anticancer drugshttp://science.sciencemag.org/content/362/6416/734.full

TXNIP-Dependent Extracellular Matrix Remodeling Drives Glycolysishttp://cancerdiscovery.aacrjournals.org/content/8/11/OF9

Biochimica et Biophysica Acta (BBA) – Bioenergetics
20th European Bioenergetics Conference – abstracts -https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-bioenergetics/vol/1859/suppl/S

MetaboList – October 2018


Glucose metabolism, glycolytic enzymes


Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals – Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Peder J. Lund, Mariana Lopes, Benjamin A. Garcia, Kathryn E. Wellen, David G. Kirsch and Jason W. Locasale. https://www.cell.com/cell/fulltext/S0092-8674(18)31101-2

Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells – Maria R. Depaoli, Felix Karsten, Corina T. Madreiter-Sokolowski, Christiane Klec, Benjamin Gottschalk, Helmut Bischof, Emrah Eroglu, Markus Waldeck-Weiermair, Thomas Simmen, Wolfgang F. Graier and Roland Malli. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31457-8

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling – Michael J. Bollong, Gihoon Lee, John S. Coukos, Hwayoung Yun, Claudio Zambaldo, Jae Won Chang, Emily N. Chin, Insha Ahmad, Arnab K. Chatterjee, Luke L. Lairson, Peter G. Schultz and Raymond E. Moellering. https://www.nature.com/articles/s41586-018-0622-0

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells – Haobin Ye, Biniam Adane, Nabilah Khan, Erica Alexeev, Nichole Nusbacher, Mohammad Minhajuddin, Brett M. Stevens, Amanda C. Winters, Xi Lin, John M. Ashton, Enkhtsetseg Purev, Lianping Xing, Daniel A. Pollyea, Catherine A. Lozupone, Natalie J. Serkova, Sean P. Colgan and Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30376-3

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells – Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente and Didier Y. R. Stainier. https://www.nature.com/articles/s41467-018-06406-8

PKM2 is not required for pancreatic ductal adenocarcinoma – Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio and Matthew G Vander Heiden. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0188-1


LDH and lactate


Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism – Maša Ždralević, Almut Brand, Lorenza Di Ianni, Katja Dettmer, Jörg Reinders, Katrin Singer, Katrin Peter, Annette Schnell, Christina Bruss, Sonja-Maria Decking, Gudrun Koehl, Blanca Felipe-Abrio, Jérôme Durivault, Pascale Bayer, Marie Evangelista, Thomas O’Brien, Peter J. Oefner, Kathrin Renner, Jacques Pouysségur and Marina Kreutz. http://www.jbc.org/content/293/41/15947.abstract

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival – Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman and Ze’ev A Ronai. http://EMBOJ.embopress.org/content/37/20/e99735?etoc

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth – Yuan Liu, Ji-Zheng Guo, Ying Liu, Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu, Shengtao Zhou, Xiao-Chen Lu, Hong-Bin Yang, Chenyue Xu, Wei Gao, Li Zhou, Yi-Ping Wang, Weiguo Hu, Yuquan Wei, Canhua Huang and Qun-Ying Lei. https://www.nature.com/articles/s41467-018-06841-7

Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer – Teresa Eichenlaub, René Villadsen, Flávia C.P. Freitas, Diana Andrejeva, Blanca I. Aldana, Hung Than Nguyen, Ole William Petersen, Jan Gorodkin, Héctor Herranz and Stephen M. Cohen. https://www.cell.com/current-biology/fulltext/S0960-9822(18)31119-9


Amino acids / Redox / lipid metabolism


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze. https://www.nature.com/articles/s41388-018-0315-z

Biosynthetic energy cost for amino acids decreases in cancer evolution – Hong Zhang, Yirong Wang, Jun Li, Han Chen, Xionglei He, Huiwen Zhang, Han Liang and Jian Lu. https://www.nature.com/articles/s41467-018-06461-1

Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia – Lucille Stuani, Fabien Riols, Pierre Millard, Marie Sabatier, Aurélie Batut, Estelle Saland, Fanny Viars, Laure Tonini, Sonia Zaghdoudi, Laetitia K. Linares, Jean-Charles Portais, Jean-Emmanuel Sarry and Justine Bertrand-Michel. https://www.mdpi.com/1422-0067/19/11/3325


Nucleotides


Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer – Anthony Cheung, James Opzoomer, Kristina M. Ilieva, Patrycja Gazinska, Ricarda M. Hoffmann, Hasan Mirza, Rebecca Marlow, Erika Francesch-Domenech, Matthew Fittall, Diana Dominguez Rodriguez, Angela Clifford, Luned Badder, Nirmesh Patel, Silvia Mele, Giulia Pellizzari, Heather J. Bax, Silvia Crescioli, Gyula Petranyi, Daniel Larcombe-Young, Debra H. Josephs, Silvana Canevari, Mariangela Figini, Sarah Pinder, Frank O. Nestle, Cheryl Gillett, James F. Spicer, Anita Grigoriadis, Andrew N.J. Tutt and Sophia N. Karagiannis. http://clincancerres.aacrjournals.org/content/24/20/5098

Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools – Svetlana A. Kholodar, Ananda K. Ghosh, Katarzyna Świderek, Vicent Moliner and Amnon Kohen. http://www.pnas.org/content/115/41/10311?etoc=


Mitochondria


Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism – Martin Benej, Xiangqian Hong, Sandip Vibhute, Sabina Scott, Jinghai Wu, Edward Graves, Quynh-Thu Le, Albert C. Koong, Amato J. Giaccia, Bing Yu, Shih-Ching Chen, Ioanna Papandreou and Nicholas C. Denko. http://www.pnas.org/content/115/42/10756?etoc=

Cox2p of yeast cytochrome oxidase assembles as a stand-alone subunit with the Cox1p and Cox3p modules – Leticia Veloso R. Franco, Chen Hsien Su, Gavin P. McStay, George J. Yu and Alexander Tzagoloff. http://www.jbc.org/content/early/2018/09/17/jbc.RA118.004138.abstract


Starvation / mTOR


Chronic starvation induces noncanonical pro-death stress granules – Lucas C. Reineke, Shebna A. Cheema, Julien Dubrulle and Joel R. Neilson. http://jcs.biologists.org/content/131/19/jcs220244?etoc

The mTOR-S6 kinase pathway promotes stress granule assembly – Aristeidis P. Sfakianos, Laura E. Mellor, Yoke Fei Pang, Paraskevi Kritsiligkou, Hope Needs, Hussein Abou-Hamdan, Laurent Désaubry, Gino B. Poulin, Mark P. Ashe and Alan J. Whitmarsh. https://www.nature.com/articles/s41418-018-0076-9

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux – Wei Wan, Zhiyuan You, Li Zhou, Yinfeng Xu, Chao Peng, Tianhua Zhou, Cong Yi, Yin Shi and Wei Liu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30788-3

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction – Rituraj Pal, Michela Palmieri, Arindam Chaudhury, Tiemo Jürgen Klisch, Alberto di Ronza, Joel R. Neilson, George G. Rodney and Marco Sardiello. https://www.nature.com/articles/s41467-018-06844-4

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin – Maria A. Gubbiotti, Erin Seifert, Ulrich Rodeck, Jan B. Hoek and Renato V. Iozzo. http://www.jbc.org/content/293/43/16940.long

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia – Peter van Galen, Nathan Mbong, Antonia Kreso, Erwin M. Schoof, Elvin Wagenblast, Stanley W.K. Ng, Gabriela Krivdova, Liqing Jin, Hiromitsu Nakauchi and John E. Dick. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31597-3


Hypoxia


Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia – Arpita Chowdhury, Abhishek Aich, Gaurav Jain, Katharina Wozny, Christian Lüchtenborg, Magnus Hartmann, Olaf Bernhard, Martina Balleiniger, Ezzaldin Ahmed Alfar, Anke Zieseniss, Karl Toischer, Kaomei Guan, Silvio O. Rizzoli, Britta Brügger, Andrè Fischer, Dörthe M. Katschinski, Peter Rehling and Jan Dudek. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31502-X

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury – Roman Vozdek , Yong Long and Dengke K. Ma. http://stke.sciencemag.org/content/11/550/eaat0138

MicroRNA expression profile during different conditions of hypoxia – Donato Lacedonia, Giulia Scioscia, Grazia Pia Palladino, Crescenzio Gallo, Giovanna Elisiana Carpagnano, Roberto Sabato and Maria Pia Foschino Barbaro. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=26210

Oxygen-Enhanced and Dynamic Contrast-Enhanced Optoacoustic Tomography Provide Surrogate Biomarkers of Tumor Vascular Function, Hypoxia, and Necrosis – Michal R. Tomaszewski, Marcel Gehrung, James Joseph, Isabel Quiros-Gonzalez, Jonathan A. Disselhorst and Sarah E. Bohndiek. http://cancerres.aacrjournals.org/content/78/20/5980

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment – Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu and Gregg L. Semenza. http://www.pnas.org/content/115/41/E9640?etoc=

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α – Susana Simões-Sousa, Samantha Littler, Sarah L. Thompson, Paul Minshall, Helen Whalley, Bjorn Bakker, Klaudyna Belkot, Daniela Moralli, Daniel Bronder, Anthony Tighe, Diana C.J. Spierings, Nourdine Bah, Joshua Graham, Louisa Nelson, Catherine M. Green, Floris Foijer, Paul A. Townsend and Stephen S. Taylor. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31505-5

Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen – Mathieu Deygas, Rudy Gadet, Germain Gillet, Ruth Rimokh, Philippe Gonzalo and Ivan Mikaelian. https://www.nature.com/articles/s41467-018-06988-3


IDH


Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells – Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan and Christian M. Metallo. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31534-1

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism – Mingzhu Bai, Linlin Yang, Hong Liao, Xiaoyan Liang, Bingying Xie, Ji Xiong, Xiang Tao, Xiong Chen, Yali Cheng, Xiaojun Chen, Youji Feng, Zhenbo Zhang and Wenxin Zheng. https://www.nature.com/articles/s41388-018-0360-7

IDH1R132H is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment – Patricia D. B. Tiburcio, Bing Xiao, Yi Chai, Sydney Asper, Sheryl R. Tripp, David L. Gillespie, Randy L. Jensen and L. Eric Huang. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26203&path[]=81692


Cancer immunometabolism


IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity – Minkyung Song, Tito A. Sandoval, Chang-Suk Chae, Sahil Chopra, Chen Tan, Melanie R. Rutkowski, Mahesh Raundhal, Ricardo A. Chaurio, Kyle K. Payne, Csaba Konrad, Sarah E. Bettigole, Hee Rae Shin, Michael J. P. Crowley, Juan P. Cerliani, Andrew V. Kossenkov, Ievgen Motorykin, Sheng Zhang, Giovanni Manfredi, Dmitriy Zamarin, Kevin Holcomb, Paulo C. Rodriguez, Gabriel A. Rabinovich, Jose R. Conejo-Garcia, Laurie H. Glimcher and Juan R. Cubillos-Ruiz. https://www.nature.com/articles/s41586-018-0597-x


Miscellaneous


Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells – Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri Li, Matthew G. Vander Heiden, Mieke Dewerchin and Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30391-7

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State – Clair Crewe, Nolwenn Joffin, Joseph M. Rutkowski, Min Kim, Fang Zhang, Dwight A. Towler, Ruth Gordillo and Philipp E. Scherer. https://www.cell.com/cell/fulltext/S0092-8674(18)31177-2

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response – Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko and Natalia I. Krupenko. https://www.nature.com/articles/s41467-018-06650-y

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases – Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen and Poul Nissen. https://www.nature.com/articles/s41467-018-06787-w


Reviews


Emerging Technologies to Image Tissue Metabolism – Vasilis Ntziachristos, Miguel A. Pleitez, Silvio Aime and Kevin M. Brindle. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30569-2

Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis – Sara M. Nowinski, Jonathan G. Van Vranken, Katja K. Dove and Jared Rutter. https://www.cell.com/current-biology/fulltext/S0960-9822(18)31067-4

The Different Routes to Metastasis via Hypoxia-Regulated Programs – Ana Rita Nobre, David Entenberg, Yarong Wang, John Condeelis and Julio A. Aguirre-Ghiso. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30109-0

Targeting the IDH2 Pathway in Acute Myeloid Leukemia – Maria L. Amaya and Daniel A. Pollyea. http://clincancerres.aacrjournals.org/content/24/20/4931

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti and Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9

Polyamine metabolism and cancer: treatments, challenges and opportunities – Robert A. Casero Jr, Tracy Murray Stewart and Anthony E. Pegg. https://www.nature.com/articles/s41568-018-0050-3

Fasting and cancer: molecular mechanisms and clinical application – Alessio Nencioni, Irene Caffa, Salvatore Cortellino and Valter D. Longo. https://www.nature.com/articles/s41568-018-0061-0

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer – Eugene W. Gerner, Elizabeth Bruckheimer and Alfred Cohen. http://www.jbc.org/content/early/2018/10/24/jbc.TM118.003343.abstract

The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism – Giuseppe Biamonti, Lucia Maita and Alessandra Montecucco. https://www.frontiersin.org/articles/10.3389/fonc.2018.00408/full

Mevalonate Metabolism in Cancer Stemness and Trained Immunity – Georg Gruenbacher and Martin Thurnher. https://www.frontiersin.org/articles/10.3389/fonc.2018.00394/full

Roles of polyamines in translation – Thomas E. Dever and Ivaylo P. Ivanov. http://www.jbc.org/content/early/2018/10/15/jbc.TM118.003338.abstract

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions – W. Kimryn Rathmell, Jeffrey C. Rathmell and W. Marston Linehan. http://ascopubs.org/doi/full/10.1200/JCO.2018.79.2309#.W9gWfZiw9VF

Cancer Metabolism: the Known, Unknowns – Dang CV. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18301173

Editorial for this issue of BBA-Reviews on cancer with many more interesting reviews:

https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-reviews-on-cancer/vol/1870/issue/1


Comments


AMPK Regulates the Epigenome through Phosphorylation of TET2 – Eleanor C. Fiedler and Reuben J. Shaw. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30580-1

ATF4‐amino acid circuits: a recipe for resistance in melanoma – Mario R Fernandez and John L Cleveland. http://EMBOJ.embopress.org/content/37/20/e100600?etoc


Books


Metabolic Signaling. Methods and Protocols

Editors: Sarah-Maria Fendt and Sophia Y. Lunt

Springer Protocols

DOI – https://doi.org/10.1007/978-1-4939-8769-6

https://link.springer.com/book/10.1007/978-1-4939-8769-6

MetaboList – September 2018

 


Glucose metabolism/glycolytic enzymes


Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization – William J. Sullivan, Peter J. Mullen, Ernst W. Schmid, Aimee Flores, Milica Momcilovic, Mark S. Sharpley, David Jelinek, Andrew E. Whiteley, Matthew B. Maxwell, Blake R. Wilde, Utpal Banerjee, Hilary A. Coller, David B. Shackelford, Daniel Braas, Donald E. Ayer, Thomas Q. de Aguiar Vallim, William E. Lowry, Heather R. Christofk. https://www.cell.com/cell/fulltext/S0092-8674(18)31033-X

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis – Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Jian Li, William M. Oldham, Galina V. Beznoussenko, Alexander A. Mironov, Joseph Loscalzo & Victor W. Hsu. https://www.nature.com/articles/s41586-018-0475-6

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer – Xing-Yu Zhong, Xiu-Ming Yuan, Ying-Ying Xu, Miao Yin, Wei-Wei Yan, Shao-Wu Zou, Li-Ming Wei, Hao-Jie Lu, Yi-Ping Wang, Qun-Ying Lei. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31370-6

Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation – Zhizhou Ye, Donald E. Ayer. https://mcb.asm.org/content/38/20/e00178-18?etoc

LncRNA–FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 Signaling – Zehua Bian, Jiwei Zhang, Min Li, Yuyang Feng, Xue Wang, Jia Zhang, Surui Yao, Guoying Jin, Jun Du, Weifeng Han, Yuan Yin, Shenglin Huang, Bojian Fei, Jian Zou and Zhaohui Huang. http://clincancerres.aacrjournals.org/content/24/19/4808

Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma – Richard Mair, Alan J. Wright, Susana Ros, De-en Hu, Tom Booth, Felix Kreis, Jyotsna Rao, Colin Watts and Kevin M. Brindle. http://cancerres.aacrjournals.org/content/78/18/5408

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination – Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin & Thomas Helleday. https://www.nature.com/articles/s41467-018-06287-x

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer – Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30306-1


Nucleotides


Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures – Joo Sang Lee, Lital Adler, Hiren Karathia, Narin Carmel, Shiran Rabinovich, Noam Auslander, Rom Keshet, Noa Stettner, Alon Silberman, Lilach Agemy, Daniel Helbling, Raya Eilam, Qin Sun, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Hila Weiss, Sivan Pinto, Shelly Kalaora, Ronen Levy, Eilon Barnea, Arie Admon, David Dimmock, Noam Stern-Ginossar, Avigdor Scherz, Sandesh C.S. Nagamani, Miguel Unda, David M. Wilson III, Ronit Elhasid, Arkaitz Carracedo, Yardena Samuels, Sridhar Hannenhalli, Eytan Ruppin, Ayelet Erez. https://www.cell.com/cell/fulltext/S0092-8674(18)30913-9

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers – Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30387-5

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase – Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31261-0

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation – Costas Koufaris and Roland Nilsson. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0185-4


Amino acid metabolism


Role of glutamine synthetase in angiogenesis beyond glutamine synthesis – Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijssel, Giorgio Saladino, Federico Comitani, Annalisa Zecchin, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns, Joris Souffreau, Luc Schoonjans, Wouter H. Lamers, Yi Wu, Jurgen Haustraete, Johan Hofkens, Sandra Liekens, Richard Cubbon, Bart Ghesquière, Mieke Dewerchin, Francesco L. Gervasio, Xuri Li, Jaap D. van Buul, Xu Wu & Peter Carmeliet. https://www.nature.com/articles/s41586-018-0466-7

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes – Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, William Boyle, Ankur Karmokar, Catherine Andreadi, Jin-Li Luo, David A. Moore, Maria Viskaduraki, Matthew Blades, Graeme I. Murray, Lynne M. Howells, Anne Thomas, Karen Brown, Paul N. Cheng & Alessandro Rufini. https://www.nature.com/articles/s41598-018-30591-7

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression – Xiangming Ji, Jun Qian, S. M. Jamshedur Rahman, Peter J. Siska, Yong Zou, Bradford K. Harris, Megan D. Hoeksema, Irina A. Trenary, Chen Heidi, Rosana Eisenberg, Jeffrey C. Rathmell, Jamey D. Young & Pierre P. Massion. https://www.nature.com/articles/s41388-018-0307-z

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation – Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A Cassel, Douglas R Green, Yusen Liu, Teresa WM Fan, Ruoning Wang. https://elifesciences.org/articles/36158

Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer – Rong Zhou, Puneet Bagga, Kavindra Nath, Hari Hariharan, David A. Mankoff and Ravinder Reddy. http://cancerres.aacrjournals.org/content/78/19/5521


Redox metabolism/sensing


Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma – Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin Jr. https://www.cell.com/cell/fulltext/S0092-8674(18)31099-7

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling – Ming Luo, Li Shang, Michael D. Brooks, Evelyn Jiagge, Yongyou Zhu, Johanna M. Buschhaus, Sarah Conley, Melissa A. Fath, April Davis, Elizabeth Gheordunescu, Yongfang Wang, Ramdane Harouaka, Ann Lozier, Daniel Triner, Sean McDermott, Sofia D. Merajver, Gary D. Luker, Douglas R. Spitz, Max S. Wicha. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30388-7

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells – Suresh K. Joseph, Michael Young, Kamil Alzayady, David I. Yule, Mehboob Ali, David M. Booth and György Hajnóczky. http://www.jbc.org/content/early/2018/09/18/jbc.RA118.005624.abstract

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly – Elizabeth C Hinchy, Anja V. Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R. Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling and Michael P. Murphy. http://www.jbc.org/content/early/2018/09/19/jbc.RA118.002579.abstract


Lipid metabolism


Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation – Daniel Ackerman, Sergey Tumanov, Bo Qiu, Evdokia Michalopoulou, Michelle Spata, Andrew Azzam, Hong Xie, M. Celeste Simon, Jurre J. Kamphorst. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31269-5

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy – Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV. https://www.nature.com/articles/s41467-018-04664-0

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance – Hideki Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30312-7

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis – Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Brüning U, Scheinok S, Treps L, Cantelmo AR, Dubois C, de Zeeuw P,  Goveia J, Zecchin A, Taverna F, Morales-Rodriguez F, Brajic A, Conradi LC, Schoors S, Harjes U, Vriens K, Pilz GA, Chen R, Cubbon R, Thienpont B, Cruys B, Wong BW, Ghesquière B, Dewerchin M, De Bock K, Sagaert X, Jessberger S, Jones EAV, Gallez B, Lambrechts D, Mazzone M, Eelen G, Li X, Fendt SM, Carmeliet P. https://www.sciencedirect.com/science/article/pii/S1550413118304595

Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult – Yuxiao Yao, Shaoyang Sun, Jingjing Wang, Fei Fei, Zhaoru Dong, Ai-Wu Ke, Ruoyu He, Lei Wang, Lili Zhang, Min-Biao Ji, Qiang Li, Min Yu, Guo-Ming Shi, Jia Fan, Zhiyuan Gong and Xu Wang. http://cancerres.aacrjournals.org/content/78/19/5548


Mitochondria/fumarate


Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer – Young Kyuen Im, Ouafa Najyb, Simon-Pierre Gravel, Shawn McGuirk, Ryuhjin Ahn, Daina Z. Avizonis, Valérie Chénard, Valerie Sabourin, Jesse Hudson, Tony Pawson, Ivan Topisirovic, Michael Pollak, Julie St-Pierre and Josie Ursini-Siegel. http://cancerres.aacrjournals.org/content/78/17/4826

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30509-6

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation – Timothy I. Johnson, Ana S. H. Costa, Ashley N. Ferguson & Christian Frezza. https://www.nature.com/articles/s41419-018-0912-3


Starvation


Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase – Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek & Tracy G. Anthony. https://www.nature.com/articles/s41598-017-01041-7

Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy – Seda Avcioglu Barutcu, Nomeda Girnius, Santiago Vernia & Roger J. Davis. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1466013

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis – Helen Lin, Yiyin Chung, Chun-Ting Cheng, Ching Ouyang, Yong Fu, Ching-Ying Kuo, Kevin K. Chi, Maryam Sadeghi, Peiguo Chu, Hsing-Jien Kung, Chien-Feng Li, Kirsten H. Limesand & David K. Ann. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1450708


mTOR and nutrient sensing


Whi2 is a conserved negative regulator of TORC1 in response to low amino acids – Xianghui Chen, Guiqin Wang, Yu Zhang, Margaret Dayhoff-Brannigan, Nicola L. Diny, Mingjun Zhao, Ge He, Cierra N. Sing, Kyle A. Metz, Zachary D. Stolp, Abdel Aouacheria, Wen-Chih Cheng, J. Marie Hardwick, Xinchen Teng. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007592

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells – Tra-Ly Nguyen, Marie-Julie Nokin, Maxim Egorov, Mercedes Tomé, Clément Bodineau, Carmelo Di Primo, Lætitia Minder, Joanna Wdzieczak-Bakala, Maria Concepcion Garcia-Alvarez, Jérôme Bignon, Odile Thoison, Bernard Delpech, Georgiana Surpateanu, Yves-Michel Frapart, Fabienne Peyrot, Kahina Abbas, Silvia Terés, Serge Evrard, Abdel-Majid Khatib, Pierre Soubeyran, Bogdan I. Iorga, Raúl V. Durán and Pascal Collin. http://cancerres.aacrjournals.org/content/78/18/5384

Phospholipase D-Dependent mTORC1 Activation by Glutamine – Elyssa Bernfeld, Deepak Menon, Vishaldeep Vaghela, Ismat Zerin, Promie Faruque, Maria A. Frias and David A. Foster. http://www.jbc.org/content/early/2018/09/07/jbc.RA118.004972.abstract

mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation – Joseph G. Moloughney1, Nicole M. Vega-Cotto1, Sharon Liu1, Chadni Patel1,Peter K. Kim2, Chang-chih Wu1, Danielle Albaciete1, Cedric Magaway1,Austin Chang1, Swati Rajput1, Xiaoyang Su3, Guy Werlen1 and Estela Jacinto. http://www.jbc.org/content/early/2018/09/10/jbc.RA118.003991.abstract


Drugs: metformin, etomoxir, 2-DG


Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo – Anila K. Madiraju, Yang Qiu, Rachel J. Perry, Yasmeen Rahimi, Xian-Man Zhangn Dongyan Zhang, João-Paulo G. Camporez, Gary W. Cline, Gina M. Butrico, Bruce E. Kemp, Gregori Casals, Gregory R. Steinberg, Daniel F. Vatner, Kitt F. Petersen & Gerald I. Shulman. https://www.nature.com/articles/s41591-018-0125-4

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase – Roger W. Hunter, Curtis C. Hughey, Louise Lantier, Elias I. Sundelin, Mark Peggie, Elton Zeqiraj, Frank Sicheri, Niels Jessen, David H. Wasserman & Kei Sakamoto. https://www.nature.com/articles/s41591-018-0159-7

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis – Ajit S. Divakaruni, Wei Yuan Hsieh, Lucía Minarrieta, Tin N. Duong, Kristen K.O. Kim, Brandon R. Desousa, Alexander Y. Andreyev, Caitlyn E. Bowman, Kacey Caradonna, Brian P. Dranka, David A. Ferrick, Marc Liesa, Linsey Stiles, George W. Rogers, Daniel Braas, Theodore P. Ciaraldi, Michael J. Wolfgang, Tim Sparwasser, Luciana Berod, Steven J. Bensinger, Anne N. Murphy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30383-8

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation – Brenda Raud, Dominic G. Roy, Ajit S. Divakaruni, Tatyana N. Tarasenko, Raimo Franke, Eric H. Ma, Bozena Samborska, Wei Yuan Hsieh, Alison H. Wong, Philipp Stüve, Catharina Arnold-Schrauf, Melanie Guderian, Matthias Lochner, Shakuntala Rampertaap, Kimberly Romito, Joseph Monsale, Mark Brönstrup, Steven J. Bensinger, Anne N. Murphy, Peter J. McGuire, Russell G. Jones, Tim Sparwasser, Luciana Berod. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30384-X

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation – Feilong Wang, Song Zhang, Ivan Vuckovic, Ryounghoon Jeon, Amir Lerman, Clifford D. Folmes, Petras P. Dzeja, Joerg Herrmann. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30513-8

Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1 – Federico Lucantoni, Heiko Dussmann and Jochen H. M. Prehn. https://www.frontiersin.org/articles/10.3389/fcell.2018.00113/full


Miscellaneous


Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions – Pedro Latorre-Muro, Josue Baeza, Eric A. Armstrong, Ramón Hurtado-Guerrero, Francisco Corzana, Lindsay E. Wu, David A. Sinclair, Pascual López-Buesa, José A. Carrodeguas, John M. Denu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30600-2

High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling – Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Maria Del Carmen Rodriguez Pena, Jennifer B. Gordetsky, Eiichi Morii, Kazutake Tsujikawa, George J. Netto and Norio Nonomura. http://clincancerres.aacrjournals.org/content/24/17/4309

CD38 is methylated in prostate cancer and regulates extracellular NAD+ – Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan,Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja,David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell and Andrew S. Goldstein. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0186-3

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP – Shuang Wei, Jie Wang, Olutobi Oyinlade, Ding Ma, Shuyan Wang, Lisa Kratz, Bachchu Lal, Qingfu Xu, Senquan Liu, Sagar R. Shah, Hao Zhang, Yunqing Li, Alfredo Quiñones-Hinojosa, Heng Zhu, Zhi-yong Huang, Linzhao Cheng, Jiang Qian & Shuli Xia. https://www.nature.com/articles/s41388-018-0334-9

Extracellular Citrate and Cancer Metabolism (Letter) – Philippe Icard, Ludovic Fournel, Marco Alifano and Hubert Lincet. http://cancerres.aacrjournals.org/content/78/17/5176

Extracellular Citrate and Cancer Metabolism (Response) – Maria E. Mycielska and Edward K. Geissler. http://cancerres.aacrjournals.org/content/78/17/5177


Reviews


Nutrient Sensing in Cancer – Margaret E. Torrence and Brendan D. Manning. https://www.annualreviews.org/doi/full/10.1146/annurev-cancerbio-030617-050329

Rewiring urea cycle metabolism in cancer to support anabolism – Rom Keshet, Peter Szlosarek, Arkaitz Carracedo & Ayelet Erez. https://www.nature.com/articles/s41568-018-0054-z

The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer – Sandrine Silvente-Poirot, Florence Dalenc and Marc Poirot. http://cancerres.aacrjournals.org/content/78/17/4803

Hidden features: exploring the non-canonical functions of metabolic enzymes – Peiwei Huangyang, M. Celeste Simon. http://dmm.biologists.org/content/11/8/dmm033365

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy – Yueming Zhu, Angela Elizabeth Dean, Nobuo Horikoshi, Collin Heer, Douglas R. Spitz, and David Gius. https://www.jci.org/articles/view/120844

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

Amino acid transporters revisited: New views in health and disease – Palanivel Kandasamy, Gergely Gyimesi, Yoshikatsu Kanai, Matthias A. Hediger. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30101-4

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism – Ramon Bartrons, Helga Simon-Molas, Ana Rodríguez-García, Esther Castaño, Àurea Navarro-Sabaté, Anna Manzano, and Ubaldo E. Martinez-Outschoorn. https://www.frontiersin.org/articles/10.3389/fonc.2018.00331/full

Interplay between adenylate metabolizing enzymes and AMP‐activated protein kinase – Marcella Camici, Simone Allegrini, Maria Grazia Tozzi. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14508

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation – Myung Hee Park1 and Edith C Wolff. http://www.jbc.org/content/early/2018/09/26/jbc.TM118.003341.abstract


Comments


A Glycolysis Outsider Steps into the Cancer Spotlight – Marcus D. Goncalves, Lewis C. Cantley. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30399-1

Metabolic Frugality Marks Cancer Cells for Immune Targeting – Lucas B. Sullivan. https://www.cell.com/cell/fulltext/S0092-8674(18)31039-0

The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation – Xiaoyan Zhang & Yanzhuang Wang. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1491214

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology – Michael V. Berridge, Carole Crasso & Jiri Neuzil. https://www.tandfonline.com/doi/full/10.1080/23723556.2015.1023929

Autophagy-deficient tumor cells rely on extracellular amino acids to survive upon glutamine deprivation – Nan Zhang, Xin Yang, Fengjie Yuan, Wei-Guo Zhu & Ying Zhao. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1493314

It takes two to tango: IDH mutation and glutaminase inhibition in glioma – Qing Zhang. http://stm.sciencemag.org/content/10/460/eaav0344

Excess Fumarate or Succinate Impairs Homologous Recombinationhttp://cancerdiscovery.aacrjournals.org/content/8/9/OF7

Hyperglycemia Results in TET2 Destabilization to Promote Tumorigenesishttp://cancerdiscovery.aacrjournals.org/content/8/9/1058.1

IDH Mutations Suppress T Cell–Mediated Antitumor Immunityhttp://cancerdiscovery.aacrjournals.org/content/8/9/OF17

Disrupting Histidine Catabolism Reduces Methotrexate Sensitivityhttp://cancerdiscovery.aacrjournals.org/content/8/9/OF18

Epigenetic control by sugarhttps://www.nature.com/articles/s41568-018-0052-1

MetaboList – August 2018

 


Glucose metabolism / Lactate


Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies – Maria Apicella, Elisa Giannoni, Stephany Fiore, Karin Johanna Ferrari, Daniel Fernández-Pérez, Claudio Isella, Carlotta Granchi, Filippo Minutolo, Antonino Sottile, Paolo Maria Comoglio, Enzo Medico, Filippo Pietrantonio, Marco Volante, Diego Pasini, Paola Chiarugi, Silvia Giordano, Simona Corso. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30507-2

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo – Kevin D. Courtney, Divya Bezwada, Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Alexander M. Funk, Jennifer Wimberly, Sarah S. McNeil, Payal Kapur, Yair Lotan, Vitaly Margulis, Jeffrey A. Cadeddu, Ivan Pedrosa, Ralph J. DeBerardinis, Craig R. Malloy, Robert M. Bachoo, Elizabeth A. Maher. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30463-7

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis – Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda, Ernst Lengyel. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30508-4

Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism – Maša Ždralević, Almut Brand, Lorenza Di Ianni, Katja Dettmer, Jörg Reinders, Katrin Singer, Katrin Peter, Annette Schnell, Christina Bruss, Sonja-Maria Decking, Gudrun Koehl, Blanca Felipe-Abrio, Jérôme Durivault, Pascale Bayer, Marie Evangelista, Thomas O’Brien, Peter J. Oefner, Kathrin Renner, Jacques Pouysségur and Marina Kreutz. http://www.jbc.org/content/early/2018/08/28/jbc.RA118.004180.abstract

GAPDH with NAD+-binding site mutation competitively inhibits the wild-type and affects glucose metabolism in cancer – Kunjithapatham R, Ganapathy-Kanniappan S. https://www.sciencedirect.com/science/article/pii/S0304416518302423?via%3Dihub

O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1 – Hiroki Sekine, Keito Okazaki, Koichiro Kato, M. Morshedul Alam, Hiroki Shima, Fumiki Katsuoka, Tadayuki Tsujita, Norio Suzuki, Akira Kobayashi, Kazuhiko Igarashi, Masayuki Yamamoto, Hozumi Motohashi. https://mcb.asm.org/content/38/17/e00252-18


Amino acid metabolism


Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting – Furkan Alkan, Katharina E. Walter, Alba Luengo, Corina T. Madreiter-Sokolowski, Sarah Stryeck, Allison N. Lau, Wael Al-Zoughbi, Caroline A. Lewis, Craig J. Thomas, Gerald Hoefler, Wolfgang F. Graier, Tobias Madl, Matthew G. Vander Heiden, Juliane G. Bogner-Strauss. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30464-9

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 – Mylène Tajan, Andreas K. Hock, Julianna Blagih, Neil A. Robertson, Christiaan F. Labuschagne, Flore Kruiswijk, Timothy J. Humpton, Peter D. Adams, Karen H. Vousden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30448-0

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response – Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara, Yuka Hasegawa, Kosei Toyoshima, Yasuko Tsuchiya, Daisuke Tomita, Jun Fujimoto, Osamu Kurasawa, Chisato Takahara, Ayumi Ando, Ryuichi Nishigaki, Yoshinori Satomi, Akito Hata, and Takahito Hara. http://www.pnas.org/content/115/33/E7776

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis – Guy Eelen, Charlotte Dubois, […] Peter Carmeliet. https://www.nature.com/articles/s41586-018-0466-7

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang. https://www.cell.com/current-biology/fulltext/S0960-9822(18)30764-4

CARM1 suppresses de novo serine synthesis by promoting PKM2 activity – Tharindumala Abeywardana, Myungeun Oh, Lei Jiang, Ying Yang, Mei Kong, Jikui Song and Yanzhong Yang. http://www.jbc.org/content/early/2018/08/21/jbc.RA118.004512.abstract

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis – Patrick Murphy, Michael A. Giacomantonio, Joao A. Paulo, Robert A. Everley, Barry E. Kennedy, Gopal P. Pathak, Derek R. Clements, Youra Kim, Cathleen Dai, Tanveer Sharif, Steven P. Gygi, Shashi Gujar. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31219-1

Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment – Liang Wang, Wen Peng, Tianming Wu, Pengchi Deng & Ying-Lan Zhao. https://www.nature.com/articles/s41420-018-0086-x


Lipid metabolism


Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins – Maomao Zhang, Julie S. Di Martino, Robert L. Bowman, Nathaniel R. Campbell, Sanjeethan C. Baksh, Theresa Simon-Vermot, Isabella S. Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R. Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E. Ariyan, Kivanç Birsoy, Jedd D. Wolchok, Katherine S. Panageas, Travis Hollmann, Jose Javier Bravo-Cordero and Richard M. White. http://cancerdiscovery.aacrjournals.org/content/8/8/1006

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation – Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C.S. Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F. Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V. Swinnen, Jordan L. Meier, Rhushikesh A. Kulkarni, Albert Sickmann, Bart Ghesquière, Luc Schoonjans, Xuri Li, Massimiliano Mazzone, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30462-5

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis – Seher Balaban Lisa S Lee Bianca Varney Atqiya Aishah Quanqing Gao Robert F Shearer Darren N Saunders Thomas Grewal Andrew J. Hoy. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12368

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer – Viktor Brovkovych, Yasir Izhar, Jeanne M. Danes, Oleskii Dubrovskyi, Isin T. Sakallioglu, Lauren M. Morrow, G. Ekin Atilla-Gokcumen & Jonna Frasor. https://www.nature.com/articles/s41389-018-0076-0

Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC) – Yifan Kong, Lijun Cheng, Fengyi Mao, Zhuangzhuang Zhang, Yanquan Zhang, Elia Farah, Jacob Bosler, Yunfeng Bai, Nihal Ahmad, Shihuan Kuang, Lang Li and Xiaoqi Liu. http://www.jbc.org/content/early/2018/08/08/jbc.RA118.004442.abstract


Nucleotides


Metabolomic profiling of human lung tumor tissues: nucleotide metabolism as a candidate for therapeutic interventions and biomarkers – Paula Moreno, Carla Jiménez‐Jiménez, Martín Garrido‐Rodríguez, Mónica Calderón‐Santiago, Susana Molina, Maribel Lara‐Chica, Feliciano Priego‐Capote, Ángel Salvatierra, Eduardo Muñoz, Marco A Calzado. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12369


Mitochondria


Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30507-2

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency – Bocca C, Kane MS, Veyrat-Durebex C, Chupin S, Alban J, Kouassi Nzoughet J, Le Mao M, Chao de la Barca JM, Amati-Bonneau P, Bonneau D, Procaccio V, Lenaers G, Simard G, Chevrollier A, Reynier P. https://www.nature.com/articles/s41598-018-29972-9

p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells – Hidekazu Nagano, Naoko Hashimoto, Akitoshi Nakayama, Sawako Suzuki, Yui Miyabayashi, Azusa Yamato, Seiichiro Higuchi, Masanori Fujimoto, Ikki Sakuma, Minako Beppu, Masataka Yokoyama, Yutaka Suzuki, Sumio Sugano, Kazuhiro Ikeda, Ichiro Tatsuno, Ichiro Manabe, Koutaro Yokote, Satoshi Inoue, and Tomoaki Tanaka. http://www.pnas.org/content/115/33/8370?etoc

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly – Jonathan G. Van Vranken, Sara M. Nowinski, Katie J. Clowers, Mi-Young Jeong, Yeyun Ouyang, Jordan A. Berg, Jeremy P. Gygi, Steven P. Gygi, Dennis R. Winge, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30514-8

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation – Kathleen A. Boyle, Jonathan Van Wickle, R. Blake Hill, Adriano Marchese, Balaraman Kalyanaraman and Michael B. Dwinell. http://www.jbc.org/content/early/2018/08/07/jbc.RA117.001469.abstract

Mitochondrial Complex I Activity Is Required for Maximal Autophagy – Hala Elnakat Thomas, Yu Zhang, Jonathan A. Stefely, Sonia R. Veiga, George Thomas, Sara C. Kozma, Carol A. Mercer. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31234-8?

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity – Caroline Giessner, Virginie Millet, Konrad J Mostert, Thomas Gensollen, Thien-Phong Vu Manh, Marc Garibal, Binta Dieme, Noudjoud Attaf-Bouabdallah, Lionel Chasson, Nicolas Brouilly, Caroline Laprie, Tom Lesluyes, Jean Yves Blay, Laetitia Shintu, Jean Charles Martin, Erick Strauss, Franck Galland, Philippe Naquet. http://www.life-science-alliance.org/content/1/4/e201800073


Starvation / nutrient sensing


The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms – Arvin B. Tam, Lindsay S. Roberts, Vivek Chandra, Io Guane Rivera, Daniel K. Nomura, Douglass J. Forbes, Maho Niwa. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30329-0

Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis – Paulo A. Gameiro, Kevin Struhl. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31111-2

A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold – Rosalie E. Lawrence, Kelvin F. Cho, Ronja Rappold, Anna Thrun, Marie Tofaute. https://www.nature.com/articles/s41556-018-0148-6

Feedback regulation of TORC1 by its downstream effectors Npr1 and Par33 – Natalia V. Varlakhanova, Bryan A. Tornabene, and Marijn G. J. Ford. https://www.molbiolcell.org/doi/10.1091/mbc.E18-03-0158?ai=25zg&ui=2oy6&af=T

Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism – Keren E. Shapira, Marcelo Ehrlichand, Yoav I. Henis. https://www.molbiolcell.org/doi/10.1091/mbc.E18-03-0175?ai=25zg&ui=2oy6&af=T


Cancer immunometabolism


Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 – Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung-Oe Lim, Chia-Wei Li, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Jennifer L. Hsu, Hung-Ling Wang, Chu-Wei Kuo, Wei-Chao Chang, Sirwan Hadad, Colin A. Purdie, Aaron M. McCoy, Shirong Cai, Yizheng Tu, Jennifer K. Litton, Elizabeth A. Mittendorf, Stacy L. Moulder, William F. Symmans, Alastair M. Thompson, Helen Piwnica-Worms, Chung-Hsuan Chen, Kay-Hooi Khoo, Mien-Chie Hung. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30599-9

Hexokinase 2 is dispensable for T cell-dependent immunity – Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay and Navdeep S. Chandel. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0184-5

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death – Tsadik Habtetsion, Zhi-Chun Ding, Wenhu Pi, Tao Li, Chunwan Lu, Tingting Chen, Caixia Xi, Helena Spartz, Kebin Liu, Zhonglin Hao, Nahid Mivechi, Yuqing Huo, Bruce R. Blazar, David H. Munn, Gang Zhou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30319-X

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression – Jingjing Cong, Xianwei Wang, Xiaohu Zheng, Dong Wang, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30443-1


Miscellaneous


Myc and ChREBP Transcription Factors Cooperatively Regulate Normal and Neoplastic Hepatocyte Proliferation in Mice – Huabo Wang, James M. Dolezal, Sucheta Kulkarni, Jie Lu, Jordan Mandel, Laura E. Jackson, Frances Alencastro, Andrew W. Duncan and Edward V. Prochownik. http://www.jbc.org/content/early/2018/08/07/jbc.RA118.004099.abstract

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment – Matheus Dyczynski, Mattias Vesterlund, Ann-Charlotte Björklund, Vasilios Zachariadis, Jerry Janssen, Hector Gallart-Ayala, Evangelia Daskalaki, Craig E. Wheelock, Janne Lehtiö, Dan Grandér, Katja Pokrovskaja Tamm, Roland Nilsson. https://www.nature.com/articles/s41419-018-0625-7

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib – Lynn Quek, Muriel D. David, […] Paresh Vyas. https://www.nature.com/articles/s41591-018-0115-6

Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development – Jiaqing Hao, Yuwen Zhang, Xiaofang Yan, Fei Yan, Yanwen Sun, Jun Zeng, Sabine Waigel, Yanhui Yin, Mostafa M. Fraig, Nejat K. Egilmez, Jill Suttles, Maiying Kong, Shujun Liu, Margot P. Cleary, Edward Sauter, Bing Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30449-2


Reviews


Biological Role and Therapeutic Potential of IDH Mutations in Cancer – Matthew S. Waitkus, Bill H. Diplas, Hai Yan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30182-X

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9

Translating In Vitro T Cell Metabolic Findings to In VivoTumor Models of Nutrient Competition – Christopher Ecker and James L. Riley. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30452-2?dgcid=raven_jbs_etoc_email

The different axes of the mammalian mitochondrial unfolded protein response – Christian Münch. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0548-x

RAS signalling in energy metabolism and rare human diseases – Dard, N. Bellance, D. Lacombe, R. Rossignol. https://www.sciencedirect.com/science/article/pii/S0005272818301063

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies – Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden. http://dmm.biologists.org/content/11/8/dmm035758

Regulation of chromatin and gene expression by metabolic enzymes and metabolites – Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger & Zhimin Lu. https://www.nature.com/articles/s41580-018-0029-7

Perspectives on IDH Mutation in Diffuse Gliomas – Yu-Ting Su, Funita P. Phan, Jing Wu. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30152-3

Interplay between YAP/TAZ and Metabolism – Ja Hyun Koo, Kun-Liang Guan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30453-4

Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase – Tereza Golias, Martin Kery, Silvia Radenkovic, Ioanna Papandreou. https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31812#.W3pybxmKn0k.twitter

Metabolic Plasticity of Tumor Cell Mitochondria – Giuseppe Cannino, Francesco Ciscato, Ionica Masgras, Carlos Sánchez-Martín, and Andrea Rasola. https://www.frontiersin.org/articles/10.3389/fonc.2018.00333/full

Understanding lymphocyte metabolism for use in cancer immunotherapy – Sarah MacPherson, Marisa Kilgour, Julian J. Lum. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14454

The big picture: exploring the metabolic cross-talk in cancer – Almut Schulze, Mariia Yuneva. http://dmm.biologists.org/content/11/8/dmm036673


Comments


Lysosomal catch-and-release controls mTORC1 – Aaron M. Hosios & Brendan D. Manning. https://www.nature.com/articles/s41556-018-0188-y

ERADicate Tumor Progression with Metformin – Lena-Sophie Dreher, Thorsten Hoppe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30635-X

An OXPHOS Inhibitor Has Antitumor Activity in Multiple Tumor Models http://cancerdiscovery.aacrjournals.org/content/8/8/OF13

Second-Site IDH2 Mutations Confer Resistance to Enasidenib In Trans http://cancerdiscovery.aacrjournals.org/content/8/8/913.2

Starving cancer cells to death: Cisplatin-resistant cancer cells are particularly susceptible to starvation-induced death. http://stke.sciencemag.org/content/11/542/eaau9719

MetaboList – July 2018

———————————————–
Amino acid metabolism
———————————————-

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
Anneleen Daemen, Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, David Peterson, Bianca M. Liederer, Cecile de la Cruz, Dewakar Sangaraju, Allan Jaochico, Xiaofeng Zhao, Wendy Sandoval, Thomas Hunsaker, Ron Firestein, Sheerin Latham, Deepak Sampath, Marie Evangelista, Georgia Hatzivassiliou
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30385-1

Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini
https://www.nature.com/articles/s41586-018-0316-7

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A. Lewis, Richard L. Possemato & Kıvanç Birsoy
https://www.nature.com/articles/s41556-018-0118-z

Metabolic vulnerability of cisplatin‐resistant cancers
Florine Obrist, Judith Michels, Sylvere Durand, Alexis Chery, Jonathan Pol, Sarah Levesque, Adrien Joseph, Valentina Astesana, Federico Pietrocola, Gen Sheng Wu, Maria Castedo and Guido Kroemer
http://EMBOJ.embopress.org/content/37/14/e98597?etoc

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Glucose metabolism
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Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging
Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong, Jing Gao, and Hongda Wang
http://www.pnas.org/content/115/27/7033

MicroRNA-31-5p enhances the Warburg effect via targeting FIH
Biying Zhu, Xiuye Cao, Wenqiang Zhang, Guoping Pan, Qing Yi, Wenbin Zhong, and Daoguang Yan
https://www.fasebj.org/doi/abs/10.1096/fj.201800803R?ai=ts&ui=ly8&af=T

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells
Audrey Berthe, Marie Zaffino, Claire Muller, François Foulquier, Marine Houdou, Céline Schulz, Frédéric Bost, Elia De Fay, Sabine Mazerbourg,  Stéphane Flament
https://link.springer.com/article/10.1007%2Fs10549-018-4874-z

Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C. Kolwicz Jr, Daniel Raftery & Rong Tian
https://www.nature.com/articles/s41467-018-05362-7

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Nucleotides
———————

Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini
https://www.nature.com/articles/s41586-018-0316-7

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30387-5

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Mitochondria
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Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma
Raj K. Gopal, Sarah E. Calvo, Angela R. Shih, Frances L. Chaves, Declan McGuone, Eran Mick, Kerry A. Pierce, Yang Li, Andrea Garofalo, Eliezer M. Van Allen, Clary B. Clish, Esther Oliva, and Vamsi K. Mootha
http://www.pnas.org/content/115/27/E6283?etoc=

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma
Ying Pang, Yanxin Lu, Veronika Caisova, Yang Liu, Petra Bullova, Thanh-Truc Huynh, Yiqiang Zhou, Di Yu, Zdenek Frysak, Igor Hartmann, David Taïeb, Karel Pacak and Chunzhang Yang
http://clincancerres.aacrjournals.org/content/24/14/3423

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer
Harvey R. Fernandez, Shreyas M. Gadre, Mingjun Tan, Garrett T. Graham, Rami Mosaoa, Martin S. Ongkeko, Kyu Ah Kim, Rebecca B. Riggins, Erika Parasido, Iacopo Petrini, Simone Pacini, Amrita Cheema, Rency Varghese, Habtom W Ressom, Yuwen Zhang, Christopher Albanese, Aykut Üren, Mikell Paige, Giuseppe Giaccone & Maria Laura Avantaggiati
https://www.nature.com/articles/s41418-018-0101-z

An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Jennifer R. Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi et al.  Joseph R. Marszalek
https://www.nature.com/articles/s41591-018-0052-4

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Yonathan Lissanu Deribe, Yuting Sun, Christopher Terranova, Fatima Khan, Juan Martinez-Ledesma et al.[…] P. Andrew Futreal
https://www.nature.com/articles/s41591-018-0019-5

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Yichong Zhang, Ji-Hoon Lee, Tanya T Paull, Sarah Gehrke, Angelo D’Alessandro, Qianhui Dou, Vadim N Gladyshev, Elizabeth A Schroeder, Samantha K Steyl, Brooke E Christian, Gerald S Shadel
http://stke.sciencemag.org/content/11/538/eaaq0702

LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells
Lara Gibellini, Lara Gibellini, Lorena Losi, Lorena Losi, Sara De Biasi, Sara De Biasi, Milena Nasi, Milena Nasi, Domenico Lo Tartaro, Domenico Lo Tartaro, Simone Pecorini, Simone Pecorini, Simone Patergnani, Simone Patergnani, Paolo Pinton, Paolo Pinton, Anna De Gaetano, Anna De Gaetano, Gianluca Carnevale, Gianluca Carnevale, Alessandra Pisciotta, Alessandra Pisciotta, Francesco Mariani, Luca Roncucci, Luca Roncucci, Anna Iannone, Anna Iannone, Andrea Cossarizza, Andrea Cossarizza, Marcello Pinti, and Marcello Pinti
https://www.frontiersin.org/articles/10.3389/fonc.2018.00254/full

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Starvation / diet
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Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
Alicia M. Darnell, Arvind R. Subramaniam, Erin K. O’Shea
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30516-1

Control of the polyamine biosynthesis pathway by G2-quadruplexes
Helen Louise Lightfoot, Timo Hagen, Antoine Cléry, Frédéric Hai-Trieu Allain, Jonathan Hall
https://elifesciences.org/articles/36362

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins, Chantal Pauli, Xing Du, Diana G. Wang, Xiang Li, David Wu, Solomon C. Amadiume, Marcus D. Goncalves, Cindy Hodakoski, Mark R. Lundquist, Rohan Bareja, Yan Ma, Emily M. Harris, Andrea Sboner, Himisha Beltran, Mark A. Rubin, Siddhartha Mukherjee & Lewis C. Cantley
https://www.nature.com/articles/s41586-018-0343-4

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Hypoxia
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Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins
Kalpana Deepa Priya Dorayappan, Ross Wanner, John J. Wallbillich, Uksha Saini, Roman Zingarelli, Adrian A. Suarez, David E. Cohn & Karuppaiyah Selvendiran
https://www.nature.com/articles/s41388-018-0189-0

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways
Xiaofan Guo, Wei Qiu, Qinglin Liu, Mingyu Qian, Shaobo Wang, Zongpu Zhang, Xiao Gao, Zihang Chen, Hao Xue & Gang Li
https://www.nature.com/articles/s41388-018-0261-9

Intermittent hypoxia induces a metastatic phenotype in breast cancer
Anna Chen, Jaclyn Sceneay, Nathan Gödde, Tanja Kinwel, Sunyoung Ham, Erik W Thompson, Patrick O Humbert & Andreas Möller
https://www.nature.com/articles/s41388-018-0259-3?

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia
Astrid A. Glück, Eleonora Orlando, Dominic Leiser, Michaela Poliaková, Lluís Nisa, Aurélie Quintin, Jacopo Gavini, Deborah M. Stroka, Sabina Berezowska, Lukas Bubendorf, Andree Blaukat, Daniel M. Aebersold, Michaela Medová & Yitzhak Zimmer
https://www.nature.com/articles/s41388-018-0256-6

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AMPK and LKB1
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LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis
M C Poffenberger, A Metcalfe-Roach, E Aguilar, J Chen, B E Hsu, A H Wong, R M Johnson, B Flynn, B Samborska, E H Ma, S P Gravel, L Tonelli, L Devorkin, P Kim, A Hall, S Izreig, E Loginicheva, N Beauchemin, P M Siegel, M N Artyomov, J J Lum, G Zogopoulos, J Blagih, R G Jones
http://science.sciencemag.org/content/361/6400/406.full

AMP kinase promotes glioblastoma bioenergetics and tumour growth
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M. Chow, Zaza Khuchua, Matthew Kofron, Matthew T. Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov & Biplab Dasgupta
https://www.nature.com/articles/s41556-018-0126-z

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells
RICARDO J. ANTONIA, ALBERT S. BALDWIN
http://stke.sciencemag.org/content/11/538/eaan5850

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mTOR
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mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma
Luca Drusian, Elisa Agnese Nigro, Valeria Mannella, Roberto Pagliarini, Monika Pema, Ana S.H. Costa, Fabio Benigni, Alessandro Larcher, Marco Chiaravalli, Edoardo Gaude, Francesco Montorsi, Umberto Capitanio, Giovanna Musco, Christian Frezza, Alessandra Boletta
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31048-9

TORC1 inhibition enhances immune function and reduces infections in the elderly
Joan B. Mannick, Melody Morris, Hans-Ulrich P. Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins1, Tea Shavlakadze1, Weihua Zhou1, Dean Quinn, David J. Glass1 and Lloyd B. Klickstein
http://stm.sciencemag.org/content/10/449/eaaq1564

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Metabolism and chromatin
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Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu, Di Hu, […] Yujiang Geno Shi
https://www.nature.com/articles/s41586-018-0350-5

Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors
Ashley R. Maiuri, Hongde Li, Barry D. Stein, Jason M. Tennessen and Heather M. O’Hagan
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0182-7

α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
Sandra Atlante, Alessia Visintin, Elisabetta Marini, Matteo Savoia, Chiara Dianzani Marta Giorgis, Duran Sürün,Federica Maione, Frank Schnütgen, Antonella Farsetti, Andreas M. Zeiher, Massimo Bertinaria, Enrico Giraudo, Francesco Spallotta, Chiara Cencioni & Carlo Gaetano
https://www.nature.com/articles/s41419-018-0802-8

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Metabolic cell-cell cross-talk
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Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Dhruv Kumar, Jacob New, Vikalp Vishwakarma, Radhika Joshi, Jonathan Enders, Fangchen Lin, Sumana Dasari, Wade R. Gutierrez, George Leef, Sivapriya Ponnurangam, Hemantkumar Chavan, Lydia Ganaden, Mackenzie M. Thornton, Hongying Dai, Ossama Tawfik, Jeffrey Straub, Yelizaveta Shnayder, Kiran Kakarala, Terance Ted Tsue, Douglas A. Girod, Bennett Van Houten, Shrikant Anant, Partha Krishnamurthy and Sufi Mary Thomas
http://cancerres.aacrjournals.org/content/78/14/3769

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30306-1

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In vivo imaging
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Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients
Vesselin Z. Miloushev, Kristin L. Granlund, Rostislav Boltyanskiy, Serge K. Lyashchenko, Lisa M. DeAngelis, Ingo K. Mellinghoff, Cameron W. Brennan, Vivian Tabar, T. Jonathan Yang, Andrei I. Holodny, Ramon E. Sosa, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb and Kayvan R. Keshari
http://cancerres.aacrjournals.org/content/78/14/3755

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect
Bradley T. Scroggins, Masayuki Matsuo, Ayla O. White, Keita Saito, Jeeva P. Munasinghe, Carole Sourbier, Kazutoshi Yamamoto, Vivian Diaz, Yoichi Takakusagi, Kazuhiro Ichikawa, James B. Mitchell, Murali C. Krishna and Deborah E. Citrin
http://clincancerres.aacrjournals.org/content/24/13/3137

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Miscellaneous
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Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer
Yongliang Wang, Ali R. Nasiri, William E. Damsky, Curtis J. Perry, Xian-Man Zhang, Aviva Rabin-Court, Michael N. Pollak, Gerald I. Shulman, Rachel J. Perry
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30903-3

Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress
Krissie Lenting, Mohammed Khurshed, Tom H. Peeters, Corina N. A. M. van den Heuvel, Sanne A. M. van Lith, Tessa de Bitter, Wiljan Hendriks, Paul N. Span, Remco J. Molenaar, Dennis Botman, Kiek Verrijp, Arend Heerschap, Mark ter Laan, Benno Kusters, Anne van Ewijk, Martijn A. Huynen, Cornelis J. F. van Noorden, and William P. J. Leenders
https://www.fasebj.org/doi/abs/10.1096/fj.201800907RR?ai=ts&ui=ly8&af=T

Systems analysis of intracellular pH vulnerabilities for cancer therapy
Erez Persi, Miquel Duran-Frigola, Mehdi Damaghi, William R. Roush, Patrick Aloy, John L. Cleveland, Robert J. Gillies & Eytan Ruppin
https://www.nature.com/articles/s41467-018-05261-x

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Ajit S. Divakaruni, Wei Yuan Hsieh, […], Steven J. Bensinger, Anne N. Murphy
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30383-8

FABP4 as a key determinant of metastatic potential of ovarian cancer
Kshipra M. Gharpure, Sunila Pradeep, […] Anil K. Sood
https://www.nature.com/articles/s41467-018-04987-y

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Reviews
———————–

Metabolic Signaling to the Nucleus in Cancer
Sydney L. Campbell, Kathryn E. Wellen
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30584-7

Metabolic regulation of chromatin modifications and gene expression
Juan Manuel Schvartzman, Craig B. Thompson, Lydia W.S. Finley
http://jcb.rupress.org/content/217/7/2247

The nutrient environment affects therapy
BY ALEXANDER MUIR, MATTHEW G. VANDER HEIDEN
http://science.sciencemag.org/content/360/6392

The multifaceted contributions of mitochondria to cellular metabolism
Jessica B. Spinelli & Marcia C. Haigis
https://www.nature.com/articles/s41556-018-0124-1

Unraveling the Role of Angiogenesis in Cancer Ecosystems
Iratxe Zuazo-Gaztelu, and Oriol Casanovas
https://www.frontiersin.org/articles/10.3389/fonc.2018.00248/full

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Verónica Eisner, Martin Picard & György Hajnóczky
https://www.nature.com/articles/s41556-018-0133-0

NRF2 and the Hallmarks of Cancer
Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30127-2

Modulation of the secretory pathway by amino-acid starvation
Wessel van Leeuwen, Felix van der Krift, Catherine Rabouille
http://jcb.rupress.org/content/217/7/2261

Glutathione metabolism in cancer progression and treatment resistance
Ankita Bansal, M. Celeste Simon
http://jcb.rupress.org/content/217/7/2291

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Comments / other
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Histidine metabolism boosts cancer therapy
Christian Frezza
https://www.nature.com/articles/d41586-018-05573-4

Pro-tumorigenic AMPK in glioblastoma
Nektaria Maria Leli & Constantinos Koumenis
https://www.nature.com/articles/s41556-018-0129-9

Periodic fasting starves cisplatin‐resistant cancers to death
Novella Guidi and Valter D Longo
http://EMBOJ.embopress.org/content/37/14/e99815?etoc

Grasping for aspartate in tumour metabolism
Accalia Fu & Nika N. Danial
https://www.nature.com/articles/s41556-018-0137-9

A Glycolysis Outsider Steps into the Cancer Spotlight
Marcus D. Goncalves, Lewis C. Cantley
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30399-1

Spoon-Feeding Ribosomes to Autophagy
Hitoshi Nakatogawa
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30550-1

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming
Lorena Esteban-Martínez & Patricia Boya
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1332567

How to eliminate MYCN-positive hepatic cancer stem cells to prevent the recurrence?
Go J. Yoshida – http://www.pnas.org/content/115/28/E6388?etoc=
Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming
Xian-Yang Qin, Naoshi Dohmae, and Soichi Kojima – http://www.pnas.org/content/115/28/E6390?etoc=

Q & A – Karen Vousden
https://www.cell.com/current-biology/fulltext/S0960-9822(18)30675-4

Finding clues in the p53 maze: an interview with Karen Vousden
http://dmm.biologists.org/content/11/8/dmm035675

Erika Pearce: Fitting metabolism and immunity together, to a T
http://jcb.rupress.org/content/217/7/2223

Jerry Chipuk: A powerhouse for mitochondrial biology
http://jcb.rupress.org/content/early/2018/07/09/jcb.201807034