MetaboList – April 2021


Cancer Immunometabolism


Cell-programmed nutrient partitioning in the tumour microenvironment – Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson, Ayaka Sugiura, Allison S. Cohen, Ahmed Ali, Brian T. Do, Alexander Muir, Caroline A. Lewis, Rachel A. Hongo, Kirsten L. Young, Rachel E. Brown, Vera M. Todd, Tessa Huffstater, Abin Abraham, Richard T. O’Neil, Matthew H. Wilson, Fuxue Xin, M. Noor Tantawy, W. David Merryman, Rachelle W. Johnson, Christopher S. Williams, Emily F. Mason, Frank M. Mason, Katherine E. Beckermann, Matthew G. Vander Heiden, H. Charles Manning, Jeffrey C. Rathmell and W. Kimryn Rathmell. https://www.nature.com/articles/s41586-021-03442-1

Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity – Yiwen Zhang, Hongrong Hu, Weiwei Liu,Shu-Mei Yan3, Yuzhuang Li, Likai Tan, Yingshi Chen, Jun Liu, Zhilin Peng, Yaochang Yuan, Wenjing Huang, Fei Yu, Xin He, Bo Li, Hui Zhang. https://jitc.bmj.com/content/9/4/e002137


Glucose metabolism


The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts – Junjie Gu, Xuechun Li, Lin Zhao, Ying Yang, Chunling Xue, Yang Gao, Jing Li, Qin Han, Zhao Sun, Chunmei Bai and Robert Chunhua Zhao. https://www.nature.com/articles/s41419-021-03579-x

BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells – Calder W. Reinsborough, Hélène Ipas, Nathan S. Abell, Ellen B. Gouws, J. Paige Williams, Marvin Mercado, Carla Van Den Berg and Blerta Xhemalçe. https://www.nature.com/articles/s41388-021-01702-y

Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response – Hayato Irokawa; Satoshi Numasaki; Shin Kato; Kenta Iwai; Atsushi Inose-Maruyama; Takumi Ohdate; Gi-Wook Hwang; Takashi Toyama; Toshihiko Watanabe; Shusuke Kuge. https://portlandpress.com/biochemj/article-abstract/478/7/1453/228124

DOWN REGULATION OF LACTATE DEHYDROGENASE INITIATES APOPTOSIS IN HELA AND MCF-7 CANCER CELLS THROUGH INCREASED VOLTAGE-DEPENDENT ANION CHANNEL PROTEIN AND INHIBITION OF BCL2 – Suhail Al-Salam, Karthishwaran Kandhan,  and  Manjusha Sudhadevi. https://www.oncotarget.com/article/27950/text/

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation – Anxo Martínez-Ordoñez, Samuel Seoane, Leandro Avila, Noemi Eiro, Manuel Macía, Efigenia Arias, Fabio Pereira, Tomas García-Caballero, Noemi Gómez-Lado, Pablo Aguiar, Francisco Vizoso and Román Perez-Fernandez. https://www.nature.com/articles/s41388-021-01740-6

The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells – Wenwen Gao, Mengqiu Huang, Xi Chen, Jianping Chen, Zhiwei Zou, Linlin Li, Kaiyuan Ji, Zhirui Nie, Bingsheng Yang, Zibo Wei, Pengfei Xu, Junshuang Jia, Qianbing Zhang, Hongfen Shen, Qianli Wang, Keyi Li, Lingqun Zhu, Meng Wang, Shuangyan Ye, Sisi Zeng, Ying Lin, Zhili Rong, Yang Xu, Peng Zhu, Hui Zhang, Bingtao Hao and Qiuzhen Liu. https://www.nature.com/articles/s41419-021-03681-0

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation – Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, and Ni Tang. https://www.jci.org/articles/view/144703

HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness – Lei Bi, Yidan Ren, Maoxiao Feng, Peng Meng, Qin Wang, Weiping Chen, Qinlian Jiao, Yuli Wang, Lutao Du, Fuqiong Zhou, Yucui Jiang, Feiyan Chen, Chuanxin Wang, Bo Tang and Yunshan Wang. https://cancerres.aacrjournals.org/content/81/8/2015


Amino acids and glycosamines


Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells – Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen and Hsing-Jien Kung. https://www.nature.com/articles/s41467-021-22652-9

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 – Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann and Martin S. Denzel. https://www.nature.com/articles/s41467-021-22320-y


Lipid metabolism


Fatty acid synthesis is required for breast cancer brain metastasis – Gino B. Ferraro, Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott, Divya Bezwada, Landry Blanc, Brendan Prideaux, Xin Jin, Jessica M. Possada, Jiang Chen, Christopher R. Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy X. Chen, Kamila Naxerova, Christopher Ng, Anna M. Westermark, Mark Duquette, Sylvie Roberge, Neal I. Lindeman, Costas A. Lyssiotis, Jens Nielsen, David E. Housman, Dan G. Duda, Elena Brachtel, Todd R. Golub, Lewis C. Cantley, John M. Asara, Shawn M. Davidson, Dai Fukumura, Véronique A. Dartois, Clary B. Clish, Rakesh K. Jain and Matthew G. Vander Heiden. https://www.nature.com/articles/s43018-021-00183-y

Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis – Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G. P. Grünewald, Adrian Liston, Chantal Mathieu, Christophe M. Deroose, Johannes V. Swinnen, Diether Lambrechts, Diego di Bernardo, Shinya Kuroda, Katrien De Bock and Sarah-Maria Fendt. https://cancerres.aacrjournals.org/content/early/2021/03/04/0008-5472.CAN-20-1954

Down-regulation of SLC25A20 promotes hepatocellular carcinoma growth and metastasis through suppression of fatty-acid oxidation – Peng Yuan, Jiao Mu, Zijun Wang, Shuaijun Ma, Xiuwei Da, Jian Song, Hongxin Zhang, Le Yang, Jibin Li and Jingyue Yang. https://www.nature.com/articles/s41419-021-03648-1


Nucleotides and NAD(P)


Mitochondrial NADP+ is essential for proline biosynthesis during cell growth – Diem H. Tran, Rushendhiran Kesavan, Halie Rion, Mona Hoseini Soflaee, Ashley Solmonson, Divya Bezwada, Hieu S. Vu, Feng Cai, John A. Phillips III, Ralph J. DeBerardinis and Gerta Hoxhaj. https://www.nature.com/articles/s42255-021-00374-y

Mitochondrial NADP(H) generation is essential for proline biosynthesis – Jiajun Zhu, Simon Schwörer, Mirela Berisa, Yeon Ju Kyung,Keun Woo Ryu, Junmei Yi, Xuejun Jiang, Justin R. Cross, Craig B. Thompson. https://science.sciencemag.org/content/early/2021/04/21/science.abd5491

Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer – Craig Davison, Roisin Morelli, Catherine Knowlson, Melanie McKechnie, Robbie Carson, Xanthi Stachtea, Kylie A. McLaughlin, Vivien E. Prise, Kienan Savage, Richard H. Wilson, Karl A. Mulligan, Peter M. Wilson, Robert D. Ladner and Melissa J. LaBonte. https://www.nature.com/articles/s41523-021-00245-5


Mitochondria


PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer – Laura C. A. Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian MacKay, David Sumpton, Owen J. Sansom, Hing Y. Leung and Imran Ahmad. https://www.nature.com/articles/s41388-021-01707-7

Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth – Denise Sighel, Michela Notarangelo, Shintaro Aibara, Angela Re, Gianluca Ricci, Marianna Guida, Alessia Soldano, Valentina Adami, Chiara Ambrosini, Francesca Broso, Emanuele Filiberto Rosatti, Sara Longhi, Mariachiara Buccarelli, Quintino G. D’Alessandris, Stefano Giannetti, Simone Pacioni, Lucia Ricci-Vitiani, Joanna Rorbach, Roberto Pallini, Sandrine Roulland, Alexey Amunts, Ines Mancini, Angelika Modelska, Alessandro Quattrone. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00338-7

Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria – Marshall L. Deline, Martin Grashei, Frits H.A. van Heijster, Franz Schilling, Joshua Straub, Tobias Fromme. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000426

Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly – Bennett CF, O’Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P.. https://www.nature.com/articles/s41589-021-00772-z

Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis – Maria E. Solesio, Lihan Xie, Brendan McIntyre, Mathew Ellenberger, Erna Mitaishvili, Siddharth Bhadra-Lobo, Lisa F. Bettcher, Jason N. Bazil, Daniel Raftery, Ursula Jakob, Evgeny V. Pavlov. https://portlandpress.com/biochemj/article-abstract/478/8/1631/228286


Starvation / nutrient sensing


Kog1/Raptor mediates metabolic rewiring during nutrient limitation by controlling SNF1/AMPK activity – Zeenat Rashida , Rajalakshmi Srinivasan, Meghana Cyanam, Sunil Laxman. https://advances.sciencemag.org/content/7/16/eabe5544

THOC4 regulates energy homeostasis by stabilizing TFEB mRNA during prolonged starvation – Toshiharu Fujita, Sayaka Kubo, Tatsuya Shioda, Ayaka Tokumura, SatoshiMinami, Megumi Tsuchiya, Yoshitaka Isaka, Hidesato Ogawa, Maho Hamasaki, Li Yu, Tamotsu Yoshimori and Shuhei Nakamura. http://jcs.biologists.org/content/134/6/jcs248203?etoc

Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation – Sulhee Kim, Ina Yoon, Jonghyeon Son, Junga Park, Kibum Kim, Ji-Ho Lee, Sam-Yong Park, Beom Sik Kang, Jung Min Han, Kwang Yeon Hwang, Sunghoon Kim. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00345-4

Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis – Guang Zhang, Yang Yang, Hao Hu, Kaiyue Liu, Bingyan Li, Yu Zhu, Zhongyu Wang, Qingfa Wu and Yide Mei. https://www.nature.com/articles/s41388-021-01749-x

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy – Chien-Min Hung , Portia S. Lombardo, Nazma Malik, Sonja N. Brun, Kristina Hellberg, Jeanine L. Van Nostrand, Daniel Garcia, Joshua Baumgart, Ken Diffenderfer, John M. Asara, Reuben J. Shaw. https://advances.sciencemag.org/content/7/15/eabg4544


Miscellaneous


The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer – Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern and Pilar Blancafort. https://www.nature.com/articles/s41467-021-22101-7

Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin – David Papadopoli , Oro Uchenunu, Ranveer Palia, Nabila Chekkal, Laura Hulea, Ivan Topisirovic , Michael Pollak, Julie St-Pierre. https://www.sciencedirect.com/science/article/pii/S1476558621000099

Control of endothelial quiescence by FOXO-regulated metabolites – Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza and Michael Potente. https://www.nature.com/articles/s41556-021-00637-6

Metabolic heterogeneity of human hepatocellular carcinoma: implications for personalized pharmacological treatment – Nikolaus Berndt, Johannes Eckstein, Niklas Heucke, Tilo Wuensch, Robert Gajowski, Martin Stockmann, David Meierhofer, Hermann‐Georg Holzhütter. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15587

Proteogenomic and metabolomic characterization of human glioblastoma – Liang-Bo Wang, Alla Karpova, Marina A. Gritsenko et al. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00050-7


Reviews


Metabolic barriers to cancer immunotherapy – Kristin DePeaux and Greg M. Delgoffe. https://www.nature.com/articles/s41577-021-00541-y

Autophagy in tumour immunity and therapy – Houjun Xia, Douglas R. Green and Weiping Zou.  https://www.nature.com/articles/s41568-021-00344-2

Signaling Pathways Involved in Nutrient Sensing Control in Cancer Stem Cells: An Overview – Martha Robles-Flores, Angela P Moreno-Londoño, M Cristina Castañeda-Patlán. https://www.frontiersin.org/articles/10.3389/fendo.2021.627745/full

Linking Serine/Glycine Metabolism to Radiotherapy Resistance – Sánchez-Castillo A, Vooijs M, Kampen KR. https://www.mdpi.com/2072-6694/13/6/1191

Mitochondrial metabolism as a target for acute myeloid leukemia treatment – Svetlana B. Panina, Jingqi Pei and Natalia V. Kirienko. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00253-w

Metabolic implications of non-electrogenic ATP/ADP exchange in cancer cells: A mechanistic basis for the Warburg effect – John J. Lemasters. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000438

Mitochondrial proton leaks and uncoupling proteins – David G. Nicholls. https://www.sciencedirect.com/science/article/pii/S000527282100061X

Glutathione and its precursors in cancer – Gloria Asantewaa, Isaac S Harris. https://www.sciencedirect.com/science/article/abs/pii/S0958166921000458


Comments


Mitochondrial NADPH is a pro at Pro synthesis – Frances F. Diehl and Matthew G. Vander Heiden. https://www.nature.com/articles/s42255-021-00381-z

Fatty acid synthesis enables brain metastasis – Felix C. E. Vogel and Almut Schulze. https://www.nature.com/articles/s43018-021-00202-y

Macropinocytosis: the big drinker behind cancer cell self-consumption – Hua Su, Fei Yang, Beicheng Sun and Michael Karin. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1919969

Glucose makes Treg lose their temper – Matteo Villa, David O’Sullivan, Erika L. Pearce. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00159-8

Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress? – Ralf Baumeister, Coleen T. Murphy and Thomas Heimbucher. https://www.nature.com/articles/s41418-021-00741-y


Conference: SIBBM 2021 “FRONTIERS IN METABOLIC RESEARCH” virtual meeting – June 7th – 10th, 2021

Organized by Graziano Martello, Sirio Dupont, Massimo Santoro. https://sibbm2021.azuleon.org/welcome

MetaboList – March 2021


Nucleotides


5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING – Jingru Tian, Dingyao Zhang, Vadim Kurbatov, Qinrong Wang, Yadong Wang, Dorthy Fang, Lizhen Wu, Marcus Bosenberg, Mandar D Muzumdar, Sajid Khan, Qianjin Lu, Qin Yan, Jun Lu. https://www.embopress.org/doi/abs/10.15252/embj.2020106065

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth – Qian Wang, Yi F. Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Natasha Freidman, Lisa G. Horvath, Nigel Turner, Jeff Holst. https://onlinelibrary.wiley.com/doi/10.1002/path.5665

Rewiring of purine metabolism in response to acidosis stress in glioma stem cells – Xiaoyu Xu, Liping Wang, Qingce Zang, Shanshan Li, Limei Li, Zhixing Wang, Jiuming He, Boqin Qiang, Wei Han, Ruiping Zhang, Xiaozhong Peng and Zeper Abliz. https://www.nature.com/articles/s41419-021-03543-9


Glucose metabolism


The deubiquitinase JOSD2 is a positive regulator of glucose metabolism – Lyudmila Krassikova, Boxi Zhang, Divya Nagarajan, André Lima Queiroz, Merve Kacal, Evangelos Samakidis, Helin Vakifahmetoglu-Norberg and Erik Norberg. https://www.nature.com/articles/s41418-020-00639-1

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation – Sébastien Coassolo, Guillaume Davidson, Luc Negroni, Giovanni Gambi, Sylvain Daujat, Christophe Romier and Irwin Davidson. https://www.nature.com/articles/s41467-021-21960-4

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation – Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, Ni Tang. https://www.jci.org/articles/view/144703

SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells – Joshua A. Mason, Jordan A. Cockfield, Daniel J. Pape, Hannah Meissner, Michael T. Sokolowski, Taylor C. White, José C. Valentín López, Juan Liu, Xiaojing Liu, Inmaculada Martínez-Reyes, Navdeep S. Chandel, Jason W. Locasale, Zachary T. Schafer. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00135-2

Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients – Liu Yang, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, Zhuo Wang, Yu Dong, Dongqing Zuo, Min Xue, Yin Tang, Harvey R. Herschman, Shun Lu, Qihui Shi, and Wei Wei. https://www.pnas.org/content/118/11/e2012228118.abstract?etoc

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis – Xun Shangguan, Jianli He, Zehua Ma, Weiwei zhang, Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li, Zhixiang Xin, Quan Zheng, Ying Cao, Jiahua Pan, Baijun Dong, Jinke Cheng, Qi Wang and Wei Xue. https://www.nature.com/articles/s41467-021-22163-7

A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism – Pratik Shriwas, Dennis Roberts, Yunsheng Li, Liyi Wang, Yanrong Qian, Stephen Bergmeier, Jennifer Hines, Subhodip Adhicary, Corinne Nielsen and Xiaozhuo Chen. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00248-7

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis – Xiaoqing Luo, Enze Zheng, Li Wei, Han Zeng, Hong Qin, Xiaoyu Zhang, Meng Liao, Lin Chen, Lei Zhao, Xiong Z. Ruan, Ping Yang and Yaxi Chen. https://www.nature.com/articles/s41419-021-03596-w

Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma – Hong Xie, Jun Song, Jason Godfrey, Romain Riscal, Nicolas Skuli, Itzhak Nissim and M. Celeste Simon. https://www.nature.com/articles/s42255-021-00367-x

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis – Ying Qing, Lei Dong, Lei Gao, Chenying Li, Yangchan Li, Li   Han, Emily Prince, Brandon Tan, Xiaolan Deng, Collin Wetzel, Chao Shen, Min   Gao, Zhenhua Chen, Wei Li, Bin Zhang, Daniel Braas, Johanna ten Hoeve,   Gerardo Javier Sanchez, Huiying Chen, Lai N. Chan, Chun-Wei Chen, David Ann,   Lei Jiang, Markus Müschen, Guido Marcucci, David R. Plas, Zejuan Li, Rui Su, Jianjun Chen. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30947-3

Basigin drives intracellular accumulation of l-lactate by  harvesting protons and substrate anions – Anna-Lena Köpnick, Annika Jansen, Katharina Geistlinger, Nathan Hugo Epalle, Eric Beitz. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249110


Amino acid metabolism


mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation – Yilei Zhang, Robert V. Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen, Shu-Bing Qian and Boyi Gan. https://www.nature.com/articles/s41467-021-21841-w

Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression – Georgina D. Barnabas, Joo Sang Lee, Tamar Shami, Michal Harel, Lir Beck, Michael Selitrennik, Livnat Jerby-Arnon, Neta Erez, Eytan Ruppin and Tamar Geiger. https://cancerres.aacrjournals.org/content/81/6/1443

A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer – Lingfan Xu, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, James Beasley, Patricia McCaw, Haoyue Zhang, Sarah Young, Jeff Groth, Qianben Wang, Jason W. Locasale, Xia Gao, Dean G. Tang, Xuesen Dong, Yiping He, Daniel George, Hailiang Hu, and Jiaoti Huang. https://www.pnas.org/content/118/13/e2012748118.abstract?etoc

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling – Yamashita AS, da Costa Rosa M, Stumpo V, Rais R, Slusher BS, Riggins GJ.. https://academic.oup.com/noa/article/3/1/vdaa149/5943017

STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition – Piyada Sitthideatphaiboon, Ana Galan-Cobo, Marcelo V. Negrao, Xiao Qu, Alissa Poteete, Fahao Zhang, Diane D. Liu, Whitney E. Lewis, Haley N. Kemp, Jeff Lewis, Waree Rinsurongkawong, Uma Giri, J. Jack Lee, Jianjun Zhang, Jack A. Roth, Stephen Swisher and John V. Heymach. https://clincancerres.aacrjournals.org/content/27/6/1720


Lipid metabolism


Structure and inhibition mechanism of the human citrate transporter NaCT – David B. Sauer, Jinmei Song, Bing Wang, Jacob K. Hilton, Nathan K. Karpowich, Joseph A. Mindell, William J. Rice and Da-Neng Wang. https://www.nature.com/articles/s41586-021-03230-x

Statins repress hedgehog signaling in medulloblastoma with no bone toxicities – Qianhai Fan, Tingting Gong, Chaonan Zheng, Jessica M. Y. Ng, Jianquan Chen, Cynthia Myers, Harvey Hensley, Tom Curran and Zeng-jie Yang. https://www.nature.com/articles/s41388-021-01701-z

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer – Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen and Lisa M. Butler. https://cancerres.aacrjournals.org/content/81/7/1704


Mitochondria


Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia – Chiqi Chen , Xiaoxin Hao, Xiaoyun Lai, Ligen Liu, Jun Zhu, Hongfang Shao, Dan Huang, Hao Gu, Tinghua Zhang, Zhuo Yu, Li Xie, Xiaocui Zhang, Yi Yang, Jun Xu, Yuzheng Zhao, Zhigang Lu, Junke Zheng. https://advances.sciencemag.org/content/7/11/eabd6280

Integrated Molecular Characterization of Fumarate Hydratase–deficient Renal Cell Carcinoma – Guangxi Sun, Xingming Zhang, Jiayu Liang, Xiuyi Pan, Sha Zhu, Zhenhua Liu, Cameron M. Armstrong, Jianhui Chen, Wei Lin, Banghua Liao, Tianhai Lin, Rui Huang, Mengni Zhang, Linmao Zheng, Xiaoxue Yin, Ling Nie, Pengfei Shen, Jinge Zhao, Haoran Zhang, Jindong Dai, Yali Shen, Zhiping Li, Jiyan Liu, Junru Chen, Jiandong Liu, Zhipeng Wang, Xudong Zhu, Yuchao Ni, Dan Qin, Ling Yang, Yuntian Chen, Qiang Wei, Xiang Li, Qiao Zhou, Haojie Huang, Jin Yao, Ni Chen and Hao Zeng. https://clincancerres.aacrjournals.org/content/27/6/1734

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism – Michelle Grace Acoba, Ebru S. Selen Alpergin, Santosh Renuse, Lucía Fernández-del-Río, Ya-Wen Lu, Oleh Khalimonchuk, Catherine F. Clarke, Akhilesh Pandey, Michael J. Wolfgang, Steven M. Claypool. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00183-2

Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models – Amer Alasadi, Bin Cao, Jingjing Guo, Hanlin Tao, Juan Collantes, Victor Tan, Xiaoyang Su, David Augeri and Shengkan Jin. https://www.nature.com/articles/s41388-021-01688-7


Starvation / metabolic stress


Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1 – Pei-Yun Tsai, Min-Sik Lee, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S. Hitchcock, Frederick R. Roberts, Peter DelNero, Thomas Hank, Kim C. Honselmann, Vicente Morales Oyarvide, Mari Mino-Kenudson, Clary B. Clish, Ramesh A. Shivdasani, and Nada Y. Kalaany. https://www.pnas.org/content/118/10/e2003014118.abstract?etoc

MAPK signaling regulates c‐MYC for melanoma cell adaptation to asparagine restriction – Gaurav Pathria,  Sachin Verma,  Jun Yin, David A Scott, Ze’ev A Ronai. https://www.embopress.org/doi/abs/10.15252/embr.202051436?campaign=woletoc

Lipid remodeling in response to methionine stress in MDA-MBA-468 triple-negative breast cancer cells – Stacey L Borrego, Johannes Fahrmann, Jue Hou, Da-Wei Lin, Bruce J Tromberg, Oliver Fiehn, Peter Kaiser. https://pubmed.ncbi.nlm.nih.gov/33647277/

LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation – Ruijie Wang, Leixi Cao, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Fengmin Shao, Lirong Zhang, Mian Wu. https://advances.sciencemag.org/content/7/13/eabe5708

Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma – Krista M. Dalton, Timothy L. Lochmann, Konstantinos V. Floros, Marissa L. Calbert, Richard Kurupi, Giovanna T. Stein, Joseph McClanaghan, Ellen Murchie, Regina K. Egan, Patricia Greninger, Mikhail Dozmorov, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Lisa Shock, Jennifer Koblinski, John Glod, Sosipatros A. Boikos, Cyril H. Benes, and Anthony C. Faber. https://www.pnas.org/content/118/13/e2009620118.abstract?etoc

NIK promotes metabolic adaptation of glioblastoma cells to bioenergetic stress – Michael L. Kamradt, Ji-Ung Jung, Kathryn M. Pflug, Dong W. Lee, Victor Fanniel and Raquel Sitcheran. https://www.nature.com/articles/s41419-020-03383-z

Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation – Andrey V. Kuznetsov, Sabzali Javadov, Raimund Margreiter, Michael Grimm, Judith Hagenbuchner, Michael J. Ausserlechner. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000268


mTOR / AMPK


Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis – Xin Zhang, Xiaowen Wang, Ziqiang Yuan, Sarah J. Radford, Chen Liu, Steven K. Libutti, X.F. Steven Zheng. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00144-3

Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation – Wanchun Yang, Dejiang Pang, Mina Chen, Chongyangzi Du, Lanlan Jia, Luoling Wang, Yunling He, Wanxiang Jiang, Liping Luo, Zongyan Yu, Mengqian Mao, Qiuyun Yuan, Ping Tang, Xiaoqiang Xia, Yiyuan Cui, Bo Jing, Alexander Platero, Yanhui Liu, Yuquan Wei, Paul F. Worley, Bo Xiao. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00162-3

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3 – Mathieu Paquette, Leeanna El-Houjeiri, Linda C. Zirden, Pietri Puustinen, Paola Blanchette, Hyeonju Jeong, Kurt Dejgaard, Peter M. Siegel and Arnim Pause. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1898748


Hypoxia


Coenzyme Q biosynthesis inhibition induces HIF‐1α stabilization and metabolic switch toward glycolysis – Irene Liparulo, Christian Bergamini, Marco Bortolus, Natalia Calonghi, Giuseppe Gasparre, Ivana Kurelac, Luca Masin, Nicola Rizzardi, Michela Rugolo, Wenping Wang, Serena J. Aleo, Alisar Kiwan, Cristian Torri, Claudia Zanna, Romana Fato. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15561

The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions – Ersilia Varone, Alessandra Decio, Alexander Chernorudskiy, Lucia Minoli, Laura Brunelli, Federica Ioli, Arianna Piotti, Roberta Pastorelli, Maddalena Fratelli, Marco Gobbi, Raffaella Giavazzi and Ester Zito. https://www.nature.com/articles/s41388-021-01659-y


Cancer Immunometabolism


Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma – Jason Miska, Aida Rashidi, Catalina Lee-Chang, Peng Gao, Aurora Lopez-Rosas, Peng Zhang, Rachel Burga, Brandyn Castro, Ting Xiao, Yu Han, David Hou, Samay Sampat, Alex Cordero, Joshua S. Stoolman, Craig M. Horbinski, Mark Burns, Yana K. Reshetnyak, Navdeep S. Chandel, and Maciej S. Lesniak.  https://advances.sciencemag.org/content/7/8/eabc8929

Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma – Man Hsin Hung, Joo Sang Lee, Chi Ma, Laurence P. Diggs, Sophia Heinrich, Ching Wen Chang, Lichun Ma, Marshonna Forgues, Anuradha Budhu, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Eytan Ruppin, Tim F. Greten and Xin Wei Wang. https://www.nature.com/articles/s41467-021-21804-1

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy – Xia Liu, Celine L. Hartman, Lingyun Li, Carolyn J. Albert, Fusheng Si, Aiqin Gao, Lan Huang, Yangjing Zhao, Wenli Lin, Eddy C. Hsueh, Lizong Shen, Qixiang Shao, Daniel F. Hoft, David A. Ford, Guangyong Peng. https://stm.sciencemag.org/content/13/587/eaaz6314

Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells – Ilkka Liikanen, Colette Lauhan, Sara Quon, Kyla Omilusik, Anthony T. Phan, Laura Barceló Bartrolí, Amir Ferry, John Goulding, Joyce Chen, James P. Scott-Browne, Jason T. Yustein, Nicole E. Scharping, Deborah A. Witherden, and Ananda W. Goldrath. https://www.jci.org/articles/view/143729


Miscellaneous


MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis – Konstantinos V. Floros, JinYang Cai, Sheeba Jacob, Richard Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, Benjamin R. Belvin, Bin Hu, Madhavi Puchalapalli, Sivapriya Ramamoorthy, Kimberly Swift, Janina P. Lewis, Mikhail G. Dozmorov, John Glod, Jennifer E. Koblinski, Sosipatros A. Boikos and Anthony C. Faber. https://cancerres.aacrjournals.org/content/81/7/1896

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity – Maik Pietzner, Isobel D. Stewart, Johannes Raffler, Kay-Tee Khaw, Gregory A. Michelotti, Gabi Kastenmüller, Nicholas J. Wareham and Claudia Langenberg. https://www.nature.com/articles/s41591-021-01266-0


Reviews / comments


Amino Acid Depletion Therapies: Starving Cancer Cells to Death – Miriam Butler, Laurens T. van der Meer, Frank N. van Leeuwen. https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(21)00049-7

The metabolic landscape of RAS-driven cancers from biology to therapy – Suman Mukhopadhyay, Matthew G. Vander Heiden and Frank McCormick. https://www.nature.com/articles/s43018-021-00184-x

Cellular metabolism in the defense against microbes – Lena Pernas. http://jcs.biologists.org/content/134/5/jcs252023?etoc

Mitochondrial quality control: from molecule to organelle – Alba Roca-Portoles and Stephen W. G. Tait. https://link.springer.com/article/10.1007/s00018-021-03775-0

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation – Annalisa Roberti, Agustín F. Fernández, Mario F. Fraga. https://www.sciencedirect.com/science/article/pii/S2212877821000053

Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential – Li Na Zhao, Mikael Björklund, Matias J. Caldez, Jie Zheng and Philipp Kaldis. https://www.nature.com/articles/s41388-021-01695-8

A cancerous connection for creatine –  Wei Wong. https://stke.sciencemag.org/content/14/676/eabi7099

MetaboList – February 2021


Glucose metabolism


A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma – Jee-Eun Choi, Carlos Sebastian, Christina M. Ferrer, Caroline A. Lewis, Moshe Sade-Feldman, Thomas LaSalle, Anna Gonye, Begona G. C. Lopez, Walid M. Abdelmoula, Michael S. Regan, Murat Cetinbas, Gloria Pascual, Gregory R. Wojtkiewicz, Giorgia G. Silveira, Ruben Boon, Kenneth N. Ross, Itay Tirosh, Srinivas V. Saladi, Leif W. Ellisen, Ruslan I. Sadreyev, Salvador Aznar Benitah, Nathalie Y. R. Agar, Nir Hacohen and Raul Mostoslavsky. https://www.nature.com/articles/s42255-021-00350-6

Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer – Yinan Xiao, Ling Jin, Chaolin Deng, Ye Guan, Eleftheria Kalogera, Upasana Ray, Prabhu Thirusangu, Julie Staub, Sayantani Sarkar Bhattacharya, Haotian Xu, Xiaoling Fang and Viji Shridhar. https://www.nature.com/articles/s41388-020-01621-4

C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism – Yu Zhang, Qian Yan, Lanqi Gong, Hang Xu, Beilei Liu, Xiaona Fang, Dandan Yu, Lei Li, Ting Wei, Ying Wang, Ching Ngar Wong, Zhaojie Lyu, Ying Tang, Pak Chung Sham and Xin-Yuan Guan. https://www.nature.com/articles/s41388-020-01593-5

The Source of Glycolytic Intermediates in Mammalian Tissues – Tara TeSlaa, Caroline R. Bartman, Connor S.R. Jankowski, Zhaoyue Zhang, Xincheng Xu, Xi Xing, Lin Wang, Wenyun Lu, Sheng Hui, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30728-2


Cysteine / Glutathione


The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals – Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning. https://elifesciences.org/articles/63326

Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis – Muyun Liu, Dan Wang, Yongde Luo, Lianghao Hu, Yawei Bi, Juntao Ji, Haojie Huang, Guoqiang Wang, Liang Zhu, Jianjia Ma, Eunice Kim, Catherine K. Luo, James L. Abbruzzese, Xiaokun Li, Vincent W. Yang, Zhaoshen Li and Weiqin Lu. https://www.nature.com/articles/s41419-021-03473-6

Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11 – Subhadip Mukhopadhyay, Douglas E. Biancur, Seth J. Parker, Keisuke Yamamoto, Robert S. Banh, Joao A. Paulo, Joseph D. Mancias, and Alec C. Kimmelman. https://www.pnas.org/content/118/6/e2021475118.abstract?etoc


Amino acid metabolism


Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth – Abigail S. Krall, Peter J. Mullen, Felicia Surjono, Milica Momcilovic, Ernst W. Schmid, Christopher J. Halbrook, Apisadaporn Thambundit, Steven D. Mittelman, Costas A. Lyssiotis, David B. Shackelford, Simon R.V. Knott, Heather R. Christofk. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00057-7

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma – Shuai Wu, Takeshi Fukumoto, Jianhuang Lin, Timothy Nacarelli, Yemin Wang, Dionzie Ong, Heng Liu, Nail Fatkhutdinov, Joseph A. Zundell, Sergey Karakashev, Wei Zhou, Lauren E. Schwartz, Hsin-Yao Tang, Ronny Drapkin, Qin Liu, David G. Huntsman, Andrew V. Kossenkov, David W. Speicher, Zachary T. Schug, Chi Van Dang and Rugang Zhang. https://www.nature.com/articles/s43018-020-00160-x

Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc− for Glutathione Synthesis in Lung Cancer – Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P. Zhou, Shu-Hai Lin and Jiong Deng. https://cancerres.aacrjournals.org/content/81/3/552


Lipid metabolism


Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer – Nicole Oatman , Nupur Dasgupta, Priyanka Arora, Kwangmin Choi, Mruniya V. Gawali, Nishtha Gupta, Sreeja Parameswaran, Joseph Salomone, Julie A. Reisz, Sean Lawler, Frank Furnari, Cameron Brennan, Jianqiang Wu, Larry Sallans, Gary Gudelsky, Pankaj Desai, Brian Gebelein, Matthew T. Weirauch, Angelo D’Alessandro, Kakajan Komurov, Biplab Dasgupta. https://advances.sciencemag.org/content/7/7/eabd7459

LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer – Ramona Rudalska, Jule Harbig, Marteinn T. Snaebjornsson, Sabrina Klotz, Stefan Zwirner, Liudmyla Taranets, Florian Heinzmann, Thales Kronenberger, Michael Forster, Wei Cui, Luana D’Artista, Elias Einig, Martina Hinterleitner, Werner Schmitz, Agata Dylawerska, Tae-Won Kang, Antti Poso, Mathias T. Rosenfeldt, Nisar P. Malek, Michael Bitzer, Stefan Laufer, Bernd J. Pichler, Nikita Popov, Almut Schulze, Lars Zender and Daniel Dauch. https://www.nature.com/articles/s43018-020-00168-3

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis – Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh III, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00080-2

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer – Ji-Yoon Lee, Miso Nam, Hye Young Son, Kwangbeom Hyun, Seo Young Jang, Jong Woo Kim, Min Wook Kim, Youngae Jung , Eunji Jang, Seon-Jin Yoon 8, Jungeun Kim, Jihye Kim, Jinho Seo, Jeong-Ki Min, Kyoung-Jin Oh, Baek-Soo Han, Won Kon Kim, Kwang-Hee Bae, Jaewhan Song, Jaehoon Kim, Yong-Min Huh, Geum-Sook Hwang, Eun-Woo Lee, Sang Chul Lee. https://www.pnas.org/content/117/51/32433.long

Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth – Katelyn D. Miller, Katherine Pniewski, Caroline E. Perry, Sara B. Papp, Joshua D. Shaffer, Jesse N. Velasco-Silva, Jessica C. Casciano, Tomas M. Aramburu, Yellamelli V.V. Srikanth, Joel Cassel, Emmanuel Skordalakes, Andrew V. Kossenkov, Joseph M. Salvino and Zachary T. Schug. https://cancerres.aacrjournals.org/content/81/5/1252

The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis – Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H.K. Wong, Ben S. Wittner, Hongshan Guo, Taronish D. Dubash, Moshe Sade-Feldman, Benjamin Wesley, Elad Horwitz, Genevieve M. Boland, Dieuwke L. Marvin, Todd Bonesteel, Chenyue Lu, François Aguet, Risa Burr, Samuel S. Freeman, Laxmi Parida, Katherine Calhoun, Michelle K. Jewett, Linda T. Nieman, Nir Hacohen, Anders M. Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran and Daniel A. Haber. https://cancerdiscovery.aacrjournals.org/content/11/3/678


Mitochondria


Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells – Nont Kosaisawe, Breanne Sparta, Michael Pargett, Carolyn K. Teragawa, John G. Albeck. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00014-0

Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential – Sarah Courtois, Beatriz de Luxán-Delgado, Laure Penin-Peyta, Alba Royo-García, Beatriz Parejo-Alonso, Petra Jagust, Sonia Alcalá, Juan A. Rubiolo, Laura Sánchez 5, Bruno Sainz, Jr., Christopher Heeschen, and Patricia Sancho. https://www.mdpi.com/2072-6694/13/4/698#

BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver – Maya Z. Springer, Logan P. Poole, Lauren E. Drake, Althea Bock-Hughes, Michelle L Boland, Alexandra G. Smith, John Hart, Aparajita H. Chourasia, Ivan Liu, Grazyna Bozek and Kay F Macleod. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1877469

Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities – Luciano Garofano, Simona Migliozzi, Young Taek Oh, Fulvio D’Angelo, Ryan D. Najac, Aram Ko, Brulinda Frangaj, Francesca Pia Caruso, Kai Yu, Jinzhou Yuan, Wenting Zhao, Anna Luisa Di Stefano, Franck Bielle, Tao Jiang, Peter Sims, Mario L. Suvà, Fuchou Tang, Xiao-Dong Su, Michele Ceccarelli, Marc Sanson, Anna Lasorella and Antonio Iavarone. https://www.nature.com/articles/s43018-020-00159-4

The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters – Florian A. Schober, David Moore, Ilian Atanassov, Marco F. Moedas, Paula Clemente, Ákos Végvári, Najla El Fissi, Roberta Filograna, Anna-Lena Bucher, Yvonne Hinze, Matthew The, Erik Hedman, Ekaterina Chernogubova, Arjana Begzati, Rolf Wibom, Mohit Jain, Roland Nilsson, Lukas Käll, Anna Wedell, Christoph Freyer, Anna Wredenberg. https://advances.sciencemag.org/content/7/8/eabf0717

Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability – Chen-Hua Chuang, Madeleine Dorsch, Philip Dujardin, Sukrit Silas, Kristina Ueffing, Johanna M. Hölken, Dian Yang, Monte M. Winslow and Barbara M. Grüner. https://cancerres.aacrjournals.org/content/81/3/567


Starvation, AMPK


CRISPR screens in physiologic medium reveal conditionally essential genes in human cells – Nicholas J. Rossiter, Kimberly S. Huggler, Charles H. Adelmann, Heather R. Keys, Ross W. Soens, David M. Sabatini, Jason R. Cantor.. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00061-9

Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation – Andrey V Kuznetsov, Sabzali Javadov, Raimund Margreiter, Michael Grimm, Judith Hagenbuchner, Michael J Ausserlechner. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000268

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53 – Peng Jiang, Lejiao Ren, Li Zhi, Zhong Yu, Fengxiang Lv, Fengli Xu, Wei Peng, Xiaoyu Bai, Kunlun Cheng, Li Quan, Xiuqin Zhang, Xianhua Wang, Yan Zhang, Dan Yang, Xinli Hu, Rui-Ping Xiao. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30900-X

AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ – Yuejing Jiang, Ying Dong, Yifeng Luo, Shangwen Jiang, Fei-Long Meng, Minjia Tan, Jia Li, Yi Zang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00026-7

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner – Franziska Kopietz; Yazeed Alshuweishi; Silvia Bijland; Fatmah Alghamdi; Eva Degerman; Kei Sakamoto; Ian P. Salt, Olga Göransson. https://portlandpress.com/biochemj/article-abstract/478/3/633/227673/


mTOR


G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling – Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van ‘t Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck. https://www.cell.com/cell/fulltext/S0092-8674(20)31694-9

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C – Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, Emma Y. Wu, Matthew Kukurugya, Claire F. Maher, Rushika M. Perera, M. Paulina Ordonez, Roberto Zoncu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30925-4


Hypoxia


Homology-directed repair protects the replicating genome from metabolic assaults – Kumar Somyajit, Julian Spies, Fabian Coscia, Ufuk Kirik, Maj-Britt Rask, Ji-Hoon Lee, Kai John Neelsen, Andreas Mund, Lars Juhl Jensen, Tanya T. Paull, Matthias Mann, Jiri Lukas. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00069-1

The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI) – Yukino Kobayashi, Ami Oguro, Yuta Hirata, Susumu Imaoka. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246531

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis – Fang Zheng, Jianing Chen and Erwei Song. https://www.nature.com/articles/s41467-021-21535-3


Cancer Immunometabolism


Metabolic support of tumour-infiltrating regulatory T cells by lactic acid – McLane J. Watson, Paolo D. A. Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie L. Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, Dario A. A. Vignali, Timothy W. Hand, Amanda C. Poholek, Brett M. Morrison, Jeffrey D. Rothstein, Stacy G. Wendell and Greg M. Delgoffe. https://www.nature.com/articles/s41586-020-03045-2

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours – Roberta Zappasodi, Inna Serganova, Ivan J. Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M. Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok and Taha Merghoub. https://www.nature.com/articles/s41586-021-03326-4

Lipid signalling enforces functional specialization of Treg cells in tumours – Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel and Hongbo Chi. https://www.nature.com/articles/s41586-021-03235-6

Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors – Jang Hyun Park, Hyun-Jin Kim, Chae Won Kim, Hyeon Cheol Kim, Yujin Jung, Hyun-Soo Lee, Yunah Lee, Young Seok Ju, Ji Eun Oh, Sung-Hong Park, Jeong Ho Lee, Sung Ki Lee and Heung Kyu Lee. https://www.nature.com/articles/s41590-020-00860-7


Miscellaneous


NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes – Anju Singh, Anneleen Daemen, Dorothee Nickles, Sang-Min Jeon, Oded Foreman, Kuladeep Sudini, Florian Gnad, Stephane Lajoie, Naina Gour, Wayne Mitzner, Samit Chatterjee, Eun-Ji Choi, Buvana Ravishankar, Amy Rappaport, Namrata Patil, Mark McCleland, Leisa Johnson, George Acquaah-Mensah, Edward Gabrielson, Shyam Biswal and Georgia Hatzivassiliou. https://clincancerres.aacrjournals.org/content/27/3/877

Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation – Jung-Chin Chang, Simei Go, Eduardo H. Gilglioni, Suzanne Duijst, Daan M. Panneman, Richard J. Rodenburg, Hang Lam Li, Hsu-Li Huang, Lonny R. Levin, Jochen Buck, Arthur J. Verhoeven, Ronald P.J. Oude Elferink. https://www.sciencedirect.com/science/article/pii/S0005272820302176

NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition – Alexandra M. Moore, Lei Zhou, Jing Cui, Luyi Li, Nanping Wu, Alice Yu, Soumya Poddar, Keke Liang, Evan R. Abt, Stephanie Kim, Razmik Ghukasyan, Nooneh Khachatourian, Kristina Pagano, Irmina Elliott, Amanda M. Dann, Rana Riahi, Thuc Le, David W. Dawson, Caius G. Radu, and Timothy R. Donahue. https://www.pnas.org/content/118/8/e2012469118.abstract?etoc

Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism – Ling-Yan Cai, Shi-Jie Chen, Sen-Hao Xiao, Qin-Juan Sun, Chen-Hong Ding, Bai-Nan Zheng, Xin-Yan Zhu, Shu-Qing Liu, Feng Yang, Ya-Xi Yang, Bing Zhou, Cheng Luo, Xin Zhang and Wei-Fen Xie. https://cancerres.aacrjournals.org/content/81/4/860

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer – Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, François Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji-Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. Dannenberg, Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00056-5

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice – Padma Kadiyala, Stephen V. Carney, Jessica C. Gauss, Maria B. Garcia-Fabiani, Santiago Haase, Mahmoud S. Alghamri, Felipe J. Núñez, Yayuan Liu, Minzhi Yu, Ayman Taher, Fernando M. Nunez, Dan Li, Marta B. Edwards, Celina G. Kleer, Henry Appelman, Yilun Sun, Lili Zhao, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, and Maria G. Castro. https://www.jci.org/articles/view/139542


Reviews


The metabolism of cancer cells during metastasis – Gabriele Bergers and Sarah-Maria Fendt. https://www.nature.com/articles/s41568-020-00320-2

Flexibility and Adaptation of Cancer Cells in a Heterogenous Metabolic Microenvironment – Gabriele Grasmann, Ayusi Mondal and Katharina Leithner. https://www.mdpi.com/1422-0067/22/3/1476

Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology – Elisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo and Javier A. Menendez. https://www.frontiersin.org/articles/10.3389/fonc.2020.620641/full

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases – Yanghe Zhang, Qingfei Meng, Qianhui Sun, Zhi-Xiang Xu, Honglan Zhou, Yishu Wang. https://www.sciencedirect.com/science/article/pii/S2212877820302052

Mitophagy in tumorigenesis and metastasis – Logan P Poole, Kay F Macleod. https://link.springer.com/article/10.1007%2Fs00018-021-03774-1

Mitochondrial dynamics in cancer stem cells – Dane T. Sessions and David F. Kashatus. https://link.springer.com/article/10.1007/s00018-021-03773-2


Comments


New Insights into Oncogenic Transformation: Elevating Antioxidant and Nucleotide Levels Does the Trick – Rushendhiran Kesavan, Halie Rion, Gerta Hoxhaj. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00016-9

Lethal lipotoxicity for liver cancer therapy – Suchira Gallage, Jose Efren Barragan Avila and Mathias Heikenwalder. https://www.nature.com/articles/s43018-021-00175-y

Activating T cells with asparagine – Wei Wong. https://stke.sciencemag.org/content/14/668/eabc6178

Tumour-regulated anorexia preceding cachexia – Gang Wang, Haiying Zhang and David Lyden. https://www.nature.com/articles/s41556-021-00635-8

How does obesity promote breast cancer tumor growth? – Marc L. Reitman. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00067-X

Obesity Promotes Metabolic Rewiring That Starves Cytotoxic T Cells – https://cancerdiscovery.aacrjournals.org/content/11/2/222.1

A Lung Cancer Subtype Depends on the Hexosamine Biosynthesis Pathwayhttps://cancerdiscovery.aacrjournals.org/content/11/2/OF9

Cryo-EM Structures Reveal Mechanism of Anticancer MCT1 Inhibitorshttps://cancerdiscovery.aacrjournals.org/content/11/3/529.2


James R. Mitchell (1971–2020) – Michael Ristow, Chih-Hao Lee, Katrien De Bock, Vadim N. Gladyshev, Gökhan S. Hotamisligil, Brendan D. Manning. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00065-6

MetaboList – January 2021


Metabolic pathways (general) and cancer


Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets – Yue Gong, Peng Ji, Yun-Song Yang, Xin Hu, Yi-Zhou Jiang, Zhi-Ming Shao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30545-3

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer – Douglas E. Biancur, Kevin S. Kapner, Keisuke Yamamoto, Robert S. Banh, Jasper E. Neggers, Albert S.W. Sohn, Warren Wu, Robert T. Manguso, Adam Brown, David E. Root, Andrew J. Aguirre, Alec C. Kimmelman. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30551-9

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells – Xiphias Ge Zhu, Aleksey Chudnovskiy, Lou Baudrier, Benjamin Prizer, Yuyang Liu, Benjamin N. Ostendorf, Norihiro Yamaguchi, Abolfozl Arab, Bernardo Tavora, Rebecca Timson, Søren Heissel, Elisa de Stanchina, Henrik Molina, Gabriel D. Victora, Hani Goodarzi, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30550-7

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma – James Reigle, Dina Secic, Jacek Biesiada, Collin Wetzel, Behrouz Shamsaei, Johnson Chu, Yuanwei Zang, Xiang Zhang, Nicholas J. Talbot, Megan E. Bischoff, Yongzhen Zhang, Charuhas V. Thakar, Krishnanath Gaitonde, Abhinav Sidana, Hai Bui, John T. Cunningham, Qing Zhang, Laura S. Schmidt, W. Marston Linehan, Mario Medvedovic, David R. Plas, Julio A. Landero Figueroa, Jarek Meller, and Maria F. Czyzyk-Krzeska. https://www.jci.org/articles/view/140522

Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes – Karl Kochanowski, Timur Sander, Hannes Link, Jeremy Chang, Steven J. Altschuler, Lani F. Wu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31636-3

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors – Anna Han, Timothy J. Purwin, Nelisa Bechtel, Connie Liao, Vivian Chua, Erin Seifert, Takami Sato, Zachary T. Schug, David W. Speicher, J. William Harbour and Andrew E. Aplin. https://www.nature.com/articles/s41388-020-01554-y

Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI – Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen and May-Britt Tessem. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00242-z


Hexose metabolism


Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer – Catríona M. Dowling , Kate E. R. Hollinshead, Alessandra Di Grande, Justin Pritchard, Hua Zhang, Eugene T. Dillon, Kathryn Haley, Eleni Papadopoulos, Anita K. Mehta, Rachel Bleach, Andreas U. Lindner, Brian Mooney, Heiko Düssmann, Darran O’Connor, Jochen H. M. Prehn, Kieran Wynne, Michael Hemann, James E. Bradner, Alec C. Kimmelman, Jennifer L. Guerriero, Gerard Cagney, Kwok-Kin Wong, Anthony G. Letai, Tríona Ní Chonghaile. https://advances.sciencemag.org/content/7/3/eabc4897

The harsh microenvironment in early breast cancer selects for a Warburg phenotype – Mehdi Damaghi, Jeffrey West, Mark Robertson-Tessi, Liping Xu, Meghan C. Ferrall-Fairbanks, Paul A. Stewart, Erez Persi, Brooke L. Fridley, Philipp M. Altrock, Robert A. Gatenby, Peter A. Sims, Alexander R. A. Anderson, and Robert J. Gillies. https://www.pnas.org/content/118/3/e2011342118.abstract?etoc

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex – Xuxiao He, Min Li, Hongming Yu, Guijun Liu, Ningning Wang, Chunzhao Yin, Qiaochu Tu, Goutham Narla, Yongzhen Tao, Shuqun Cheng, Huiyong Yin. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000803

Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells – Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem and Stefan Wölfl. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00239-8

Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment – Yongbo Yu, Ye Liang, Dan Li, Liping Wang, Zhijuan Liang, Yuanbin Chen, Guofeng Ma, Hui Wu, Wei Jiao and Haitao Niu. https://www.nature.com/articles/s41420-021-00401-7

Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with localized primary gastrointestinal stromal tumors – Sang Hyun Hwang, Minkyu Jung, Yong Hyu Jeong, KwanHyeong Jo, Soyoung Kim, Jiyoung Wang and Arthur Cho. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00244-x

Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells – Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman and P. Darrell Neufer. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00241-0


Lactate


An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism – Nunu Huang, Fanying Li, Maolei Zhang, Huangkai Zhou, Zhipeng Chen, Xiaoyan Ma, Lixuan Yang, Xujia Wu, Jian Zhong, Feizhe Xiao, Xuesong Yang, Kun Zhao, Xixi Li, Xin Xia, Zexian Liu, Song Gao, Nu Zhang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30663-X

Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export – Ke Wang, Wan Huang, Ruo Chen, Peng Lin, Tao Zhang, Yun-Feng Ni, Hao Li, Jiao Wu, Xiu-Xuan Sun, Jie-Jie Geng, Yu-Meng Zhu, Gang Nan, Wei Zhang, Xi Chen, Ping Zhu, Huijie Bian, Zhi-Nan Chen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30660-4

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates – Nan Wang, Xin Jiang, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan. https://www.cell.com/cell/fulltext/S0092-8674(20)31615-9


Amino acid metabolism


The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer – Arafath K. Najumudeen, Fatih Ceteci, Sigrid K. Fey, Gregory Hamm, Rory T. Steven, Holly Hall, Chelsea J. Nikula, Alex Dexter, Teresa Murta, Alan M. Race, David Sumpton, Nikola Vlahov, David M. Gay, John R. P. Knight, Rene Jackstadt, Joshua D. G. Leach, Rachel A. Ridgway, Emma R. Johnson, Colin Nixon, Ann Hedley, Kathryn Gilroy, William Clark, Sudhir B. Malla, Philip D. Dunne, Giovanny Rodriguez-Blanco, Susan E. Critchlow, Agata Mrowinska, Gaurav Malviya, Dmitry Solovyev, Gavin Brown, David Y. Lewis, Gillian M. Mackay, Douglas Strathdee, Saverio Tardito, Eyal Gottlieb, CRUK Rosetta Grand Challenge Consortium, Zoltan Takats, Simon T. Barry, Richard J. A. Goodwin, Josephine Bunch, Martin Bushell, Andrew D. Campbell and Owen J. Sansom. https://www.nature.com/articles/s41588-020-00753-3

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy – Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom and Karen H. Vousden. https://www.nature.com/articles/s41467-020-20223-y

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis – Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S. Harris, Gina M. DeNicola. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30662-8

Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma – Richa Rathore, Katharine E. Caldwell, Charles Schutt, Caitlyn B. Brashears, Bethany C. Prudner, William R. Ehrhardt, Cheuk Hong Leung, Heather Lin, Najat C. Daw, Hannah C. Beird, Abigail Giles, Wei-Lien Wang, Alexander J. Lazar, John S.A. Chrisinger, J. Andrew Livingston, Brian A. Van Tine. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31667-3

Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer – Deanna N. Edwards, Verra M. Ngwa, Ariel L. Raybuck, Shan Wang, Yoonha Hwang, Laura C. Kim, Sung Hoon Cho, Yeeun Paik, Qingfei Wang, Siyuan Zhang, H. Charles Manning, Jeffrey C. Rathmell, Rebecca S. Cook, Mark R. Boothby, Jin Chen. https://www.jci.org/articles/view/140100

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells – Sangmoo Jeong, Angela Maria Savino, Rachel Chirayil, Ersilia Barin, Yuanming Cheng, Sun-Mi Park, Alexandra Schurer, Edouard Mullarky, Lewis C. Cantley, Michael G. Kharas, Kayvan R. Keshari. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30665-3

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells – Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S. https://www.mdpi.com/2072-6694/13/3/412

Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells – Leonard C. Rogers, Jing Zhou, Adriana Baker, Charles R. Schutt, Prashanta K. Panda and Brian A. Van Tine. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00238-9


Lipid metabolism


Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas – Nivea Dias Amoedo, Saharnaz Sarlak, Emilie Obre, Pauline Esteves, Hugues Bégueret, Yann Kieffer, Benoît Rousseau, Alexis Dupis, Julien Izotte, Nadège Bellance, Laetitia Dard, Isabelle Redonnet-Vernhet, Giuseppe Punzi, Mariana Figueiredo Rodrigues, Elodie Dumon, Walid Mafhouf, Véronique Guyonnet-Dupérat, Lara Gales, Tony Palama, Floriant Bellvert, Nathalie Dugot-Senan, Stéphane Claverol, Jean-Marc Baste, Didier Lacombe, Hamid Reza Rezvani, Ciro Leonardo Pierri, Fatima Mechta-Grigoriou, Matthieu Thumerel, and Rodrigue Rossignol. https://www.jci.org/articles/view/133081

Phospholipid dynamics in ex vivo lung cancer and normal lung explants – Julia Lesko, Alexander Triebl, Elvira Stacher-Priehse, Nicole Fink-Neuböck, Jörg Lindenmann, Freyja-Maria Smolle-Jüttner, Harald C. Köfeler, Andelko Hrzenjak, Horst Olschewski & Katharina Leithner. https://www.nature.com/articles/s12276-020-00547-x

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma – Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E. Davis, Pei Lin, P. Leif Bergsagel, Elisabet E. Manasanch, Stephen T.C. Wong, Nestor F. Esnaola, Jenny C. Chang, Robert Z. Orlowski, Qing Yi, Jing Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30666-5

A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer – Krishna B. Singh, Eun-Ryeong Hahm, Su-Hyeong Kim, Stacy G. Wendell and Shivendra V. Singh. https://www.nature.com/articles/s41388-020-01553-z

2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis – Liang Sun, Xiaoqin Yang, Xiaoheng Huang, Yizhou Yao, Xiangyu Wei, Shugao Yang, Diyuan Zhou, Wei Zhang, Zhimin Long, Xiaoyan Xu, Xinguo Zhu, Songbing He and Xiong Su. https://cancerres.aacrjournals.org/content/81/2/289

Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation – Qingyu Zhang, Wei Zhou, Shan Yu, Yaojun Ju, Sally Kit Yan To, Alice Sze Tsai Wong, Yufei Jiao, Terence Chuen Wai Poon, Kin Yip Tam and Leo Tsz On Lee. https://www.nature.com/articles/s41388-020-01516-4


Nucleotides and NADPH


Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation – Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M. Ghergurovich, Lili Guo, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30535-0

Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model – Martin P. Ogrodzinski, Shao Thing Teoh and Sophia Y. Lunt. https://cancerres.aacrjournals.org/content/81/2/303

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer – Fang Huang, Kenneth E. Huffman, Zixi Wang, Xun Wang, Kailong Li, Feng Cai, Chendong Yang, Ling Cai, Terry S. Shih, Lauren G. Zacharias, Andrew Chung, Qian Yang, Milind D. Chalishazar, Abbie S. Ireland, C. Allison Stewart, Kasey Cargill, Luc Girard, Yi Liu, Min Ni, Jian Xu, Xudong Wu, Hao Zhu, Benjamin Drapkin, Lauren A. Byers, Trudy G. Oliver, Adi F. Gazdar, John D. Minna, and Ralph J. DeBerardinis. https://www.jci.org/articles/view/139929

NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor comple – Wei Li, Junjie Kou, Junying Qin, Li Li, Zhenxi Zhang, Ying Pan, Yi Xue and Wenjing Du. https://www.nature.com/articles/s42255-020-00330-2


Mitochondrial metabolism


Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer – Daniel R. Crooks , Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, G. Mariah Cawthon, Ferri Sohelian, Natalia De Val, Ruth M. Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa W.-M. Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa, Ashkan A. Malayeri, Maria J. Merino, Youfeng Yang, Jordan L. Meier, Mark W. Ball, Tracey A. Rouault, Ramaprasad Srinivasan, W. Marston Linehan. https://stke.sciencemag.org/content/14/664/eabc4436

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice – Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera & Alessio Nencioni. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00240-1

Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer – Bianca Oresta , Chiara Pozzi, Daniele Braga, Rodolfo Hurle, Massimo Lazzeri, Piergiuseppe Colombo, Nicola Frego, Marco Erreni, Cristina Faccani, Grazia Elefante, Matteo Barcella, Giorgio Guazzoni, Maria Rescigno. https://stm.sciencemag.org/content/13/575/eaba6110

Targeting oxidative phosphorylation to increase the efficacy of radio- and immune- combination therapy – Daan F Boreel, Paul N Span, Sandra Heskamp, Gosse J. Adema and Johan Bussink. https://clincancerres.aacrjournals.org/content/early/2021/01/08/1078-0432.CCR-20-3913


Mitochondrial stress


Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction – Kendall J. Condon, Jose M. Orozco, Charles H. Adelmann, Jessica B. Spinelli, Pim W. van der Helm, Justin M. Roberts, Tenzin Kunchok, and David M. Sabatini. https://www.pnas.org/content/118/4/e2022120118.abstract?etoc

Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response – Kai Mao, Peter Breen, Gary Ruvkun. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000996

Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress – Lingjie Sang, Huai-qiang Ju, Zuozhen Yang, Qiwei Ge, Zhen Zhang, Fangzhou Liu, Luojia Yang, Hangdi Gong, Chengyu Shi, Lei Qu, Hui Chen, Minjie Wu, Hao Chen, Ruihua Li, Qianqian Zhuang, Hailong Piao, Qingfeng Yan, Weishi Yu, Liangjing Wang, Jianzhong Shao, Jian Liu, Wenqi Wang, Tianhua Zhou and Aifu Lin. https://www.nature.com/articles/s42255-020-00325-z

Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration – Zhaoying Yang, Xiaocui Zhao, Weina Shang, Yang Liu, Jun-Feng Ji, Jun-Ping Liu and Chao Tong. https://www.nature.com/articles/s41418-020-0601-5

Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway – Lin Cheng, Xu Zhang, Yu-Zhou Huang, Yu-Lan Zhu, Ling-Yun Xu, Zhi Li, Xin-Yuan Dai, Liang Shi, Xu-Jie Zhou, Ji-Fu Wei and Qiang Ding. https://www.nature.com/articles/s41389-020-00290-y

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development – Zhida Wu, Meiling Zuo, Ling Zeng, Kaisa Cui, Bing Liu, Chaojun Yan, Li Chen, Jun Dong, Fugen Shangguan, Wanglai Hu, He He, Bin Lu, Zhiyin Song. https://www.embopress.org/doi/abs/10.15252/embr.202050827


Starvation response / ATF4


PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner – Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals and Jose C. Perales. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00236-3

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis – Kwontae You, Lingfei Wang, Chih-Hung Chou, Kai Liu, Toru Nakata, Alok Jaiswal, Junmei Yao, Ariel Lefkovith, Abdifatah Omar, Jacqueline G Perrigoue, Jennifer E Towne, Aviv Regev, Daniel B Graham, Ramnik J Xavier. https://science.sciencemag.org/content/371/6524/eabb6896

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program – Rajalakshmi Srinivasan, Adhish S. Walvekar, Zeenat Rashida, Aswin Seshasayee, Sunil Laxman. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009252

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B – Alisa F. Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P. Harding, Ana Crespillo-Casado, Luke A. Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30738-3


mTOR


Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation – Sung-Hoon Kim, Jung-Hyun Choi, Peng Wang, Christopher D. Go, Geoffrey G. Hesketh, Anne-Claude Gingras, Seyed Mehdi Jafarnejad, Nahum Sonenberg. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4

Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma – Liangfang Yao, Yang Xuan, Haiyang Zhang, Bo Yang, Xinglong Ma, Tianzhen Wang, Tianyuan Meng, Wenshe Sun, Haibin Wei, Xueqing Ma, Robb Moses, Jianru Xiao, Pei Zhang, Chao Ge, Jinjun Li, Lei Li, Xiaotao Li, Jinbao Li and Bianhong Zhang. https://www.nature.com/articles/s41388-020-01558-8


Hypoxia


Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation – Omar A. Itani, Xuefei Zhong, Xiaoting Tang, Barbara A. Scott, Jun Yi Yan, Stephane Flibotte, Yiting Lim, Andrew C. Hsieh, James E. Bruce, Marc Van Gilst, C. Michael Crowder. https://www.cell.com/current-biology/fulltext/S0960-9822(20)31505-0

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis – Alina Küper, Jennifer Baumann, Kirsten Göpelt, Melanie Baumann, Christopher Sänger, Eric Metzen, Philip Kranz & Ulf Brockmeier. https://www.nature.com/articles/s41419-020-03319-7


Cancer Immunometabolism


Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion – Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk, Paolo D. A. Vignali, B. Rhodes Ford, Natalie L. Rittenhouse, Ronal Peralta, Yiyang Wang, Yupeng Wang, Kristin DePeaux, Amanda C. Poholek and Greg M. Delgoffe. https://www.nature.com/articles/s41590-020-00834-9

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion – Hongwei Lv, Guishuai Lv, Cian Chen, Qianni Zong, Guoqing Jiang, Dan Ye, Xiuliang Cui, Yufei He, Wei Xiang, Qin Han, Liang Tang, Wen Yang, Hongyang Wang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30554-4

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles – Zhaohan Wei, Xiaoqiong Zhang, Tuying Yong, Nana Bie, Guiting Zhan, Xin Li, Qingle Liang, Jianye Li, Jingjing Yu, Gang Huang, Yuchen Yan, Zelong Zhang, Bixiang Zhang, Lu Gan, Bo Huang and Xiangliang Yang. https://www.nature.com/articles/s41467-020-20723-x


Miscellaneous


Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death – Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta-Leonor Rodriguez, Marta Garcia-Cajide, Virginia Amador, Ramón Salazar, Sara C Kozma, Eric P Kusnadi, Jian Kang, Antonio Gentilella, Richard B Pearson, George Thomas, Joffrey Pelletier. https://ashpublications.org/blood/article/doi/10.1182/blood.2020007452/474958

Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer cachexia – Wenjun Hu, Hairong Xiong, Zeyuan Ru, Yan Zhao, Yali Zhou, Kairu Xie, Wen Xiao, Zhiyong Xiong, Cheng Wang, Changfei Yuan, Jian Shi, Quansheng Du, Xiaoping Zhang & Hongmei Yang. https://www.nature.com/articles/s41419-020-03382-0

IDH1 mutations induce organelle defects via dysregulated phospholipids – Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad & Mioara Larion. https://www.nature.com/articles/s41467-020-20752-6


Reviews


Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism – Ilaria Elia and Marcia C. Haigis. https://www.nature.com/articles/s42255-020-00317-z

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers – Gaurav Pathria, Ze’ev A. Ronai. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30664-1

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies – Daqian Xu, Fei Shao, Xueli Bian, Ying Meng, Tingbo Liang, Zhimin Lu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30670-7

Lipid metabolism and cancer – Xueli Bian; Rui Liu; Ying Meng; Dongming Xing; Daqian Xu; Zhimin Lu. https://rupress.org/jem/article-abstract/218/1/e20201606/211616/

Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies – Matthew S. Waitkus and Hai Yan. https://clincancerres.aacrjournals.org/content/27/2/383

Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification – Pilar Espiau-Romera, Sarah Courtois, Beatriz Parejo-Alonso, Patricia Sancho. https://www.mdpi.com/2077-0383/9/12/4128

The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells – Yoshida GJ. https://pubmed.ncbi.nlm.nih.gov/33401672/

Modification of Proteins by Metabolites in Immunity – Diskin, T.A.J. Ryan, L.A.J. O’Neill. https://www.cell.com/immunity/fulltext/S1074-7613(20)30408-8

Immunometabolic Interplay in the Tumor Microenvironment – Irem Kaymak, Kelsey S. Williams, Jason R. Cantor, Russell G. Jones. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30478-5

The diversity and breadth of cancer cell fatty acid metabolism – Shilpa R. Nagarajan, Lisa M. Butler and Andrew J. Hoy. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00237-2

Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts – Weber DD, Thapa M, Aminzadeh-Gohari S, Redtenbacher AS, Catalano L, Feichtinger RG, Koelblinger P, Dallmann G, Emberger M, Kofler B, Lang R.. https://pubmed.ncbi.nlm.nih.gov/33498757/

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia – Valentina Rausch, Valentina Sala, Fabio Penna, Paolo Ettore Porporato & Alessandra Ghigo. https://www.nature.com/articles/s41389-020-00288-6

The ins and outs of serine and glycine metabolism in cancer – Shauni L. Geeraerts, Elien Heylen, Kim De Keersmaecker & Kim R. Kampen. https://www.nature.com/articles/s42255-020-00329-9

Endoplasmic reticulum stress signals in the tumour and its microenvironment – Xi Chen & Juan R. Cubillos-Ruiz. https://www.nature.com/articles/s41568-020-00312-2


Comments


Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target  – Sanne Bootsma, Sanne M. van Neerven and Louis Vermeulen. https://www.nature.com/articles/s41588-020-00758-y

Food for Growth: Distinct Nutrient Preferences between Primary Tumors and Metastases – Yannick Audet-Delage, Julie St-Pierre. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30965-5

From the T-cell receptor to cancer therapy: an interview with Tak W. Mak – Tak W. Mak. https://www.nature.com/articles/s41418-020-00666-y

MetaboList – December 2020

Serine metabolism


In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition – Gianmarco Rinaldi, Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W Hunter, Sophia Y Lunt, Thomas G P Grünewald, Sarah-Maria Fendt. https://www.sciencedirect.com/science/article/abs/pii/S1097276520308273
 
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells – Sangmoo Jeong, Angela Maria Savino, Rachel Chirayil, Ersilia Barin, Yuanming Cheng, Sun-Mi Park , Alexandra Schurer, Edouard Mullarky, Lewis C Cantley, Michael G Kharas, Kayvan R Keshari. https://www.sciencedirect.com/science/article/abs/pii/S1550413120306604?via%3Dihub



Cystine / Glutathione


Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis – Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S Harris, Gina M DeNicola. https://www.sciencedirect.com/science/article/abs/pii/S1550413120306628
 
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition – Michael S. Binkley, Young-Jun Jeon, Monica Nesselbush, Everett J. Moding, Barzin Y. Nabet, Diego Almanza, Christian Kunder, Henning Stehr, Christopher H. Yoo, Siyeon Rhee, Michael Xiang, Jacob J. Chabon, Emily Hamilton, David M. Kurtz, Linda Gojenola, Susie Grant Owen, Ryan B. Ko, June Ho Shin, Peter G. Maxim, Natalie S. Lui, Leah M. Backhus, Mark F. Berry, Joseph B. Shrager, Kavitha J. Ramchandran, Sukhmani K. Padda, Millie Das, Joel W. Neal, Heather A. Wakelee, Ash A. Alizadeh, Billy W. Loo Jr and Maximilian Diehn. https://cancerdiscovery.aacrjournals.org/content/10/12/1826
 
Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells – Petra Jagust, Sonia Alcalá, Bruno Sainz Jr, Christopher Heeschen, Patricia Sancho. https://www.wjgnet.com/1948-0210/abstract/v12/i11/1410.htm


Glutamine and other amino acids


KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth – Susanna Raho, Loredana Capobianco, Rocco Malivindi, Angelo Vozza, Carmela Piazzolla, Francesco De Leonardis, Ruggiero Gorgoglione, Pasquale Scarcia, Francesca Pezzuto, Gennaro Agrimi, Simona N. Barile, Isabella Pisano, Stephan J. Reshkin, Maria R. Greco, Rosa A. Cardone, Vittoria Rago, Yuan Li, Carlo M. T. Marobbio, Wolfgang Sommergruber, Christopher L. Riley, Francesco M. Lasorsa, Edward Mills, Maria C. Vegliante, Giuseppe E. De Benedetto, Deborah Fratantonio, Luigi Palmieri, Vincenza Dolce and Giuseppe Fiermonte. https://www.nature.com/articles/s42255-020-00315-1
 
Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma – Yi Xiao, Anja Rabien, René Buschow, Vyacheslav Amtislavskiy, Jonas Busch, Ergin Kilic, Sonia L. Villegas, Bernd Timmermann, Moritz Schütte, Thorsten Mielke, Marie-Laure Yaspo, Klaus Jung and David Meierhofer. https://cancerres.aacrjournals.org/content/80/24/5491
 
BCAT1 affects mitochondrial metabolism independently of leucine  transamination in activated human macrophages – Jeong-Hun Ko, Antoni Olona, Adonia E. Papathanassiu, Norzawani Buang,  Kwon-Sik Park, Ana S. H. Costa, Claudio Mauro, Christian Frezza and Jacques Behmoaras. http://jcs.biologists.org/content/133/22/jcs247957?etoc
 
In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells – Wilson I. Gonsalves, Jin Sung Jang, Erik Jessen, Taro Hitosugi, Laura A. Evans, Dragan Jevremovic, Xuan-Mai Pettersson, Alexander Graham Bush, Jaimee Gransee, Emilie I. Anderson, Shaji K. Kumar and K. Sreekumaran Nair. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00235-4
 


Glucose metabolism


Increased demand for NAD+ relative to ATP drives aerobic glycolysis – Alba Luengo, Zhaoqi Li, Dan Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, Raphael Ferreira, Adi Naamati, Ahmed Ali, Caroline A. Lewis, Craig J. Thomas, Stefani Spranger, Nicholas J. Matheson, Matthew G. Vander Heiden. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30904-7
 
HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma – Ruixue Zhang, Mengqin Shen, Chunhua Wu, Yumei Chen, Jiani Lu, Jiajin Li, Li Zhao, Huannan Meng, Xiang Zhou, Gang Huang, Xiaoping Zhao and Jianjun Liu. https://www.nature.com/articles/s41419-020-03212-3
 


Lipid metabolism


A metastasis map of human cancer cell lines – Xin Jin, Zelalem Demere, Karthik Nair, Ahmed Ali, Gino B. Ferraro, Ted Natoli, Amy Deik, Lia Petronio, Andrew A. Tang, Cong Zhu, Li Wang, Danny Rosenberg, Vamsi Mangena, Jennifer Roth, Kwanghun Chung, Rakesh K. Jain, Clary B. Clish, Matthew G. Vander Heiden and Todd R. Golub. https://www.nature.com/articles/s41586-020-2969-2
 
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis – Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, and Xuejun Jiang. https://www.pnas.org/content/117/49/31189.abstract?etoc
 
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications – Youbo Zhao, Menghuan Li, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31476-5
 
Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance – Zi-Qi Zheng, Zhi-Xuan Li, Jia-Li Guan, Xu Liu, Jun-Yan Li, Yue Chen, Li Lin, Jia Kou, Jia-Wei Lv, Lu-Lu Zhang, Guan-Qun Zhou, Rui-Qi Liu, FoPing Chen, Xiao-Jun He, Ying-Qin Li, Feng Li, Si-Si Xu, Jun Ma, Na Liu and Ying Sun. https://cancerres.aacrjournals.org/content/80/23/5174

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses – Ryan Houston,Shiori Sekine,Michael J. Calderon,Fayaz Seifuddin,Guanghui Wang,Hiroyuki Kawagishi,Daniela A. Malide,Yuesheng Li,Marjan Gucek,Mehdi Pirooznia,Alissa J. Nelson,Matthew P. Stokes,Jacob Stewart-Ornstein,Steven J. Mullett,Stacy G. Wendell,Simon C. Watkins,Toren Finkel,Yusuke Sekine. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000981
 
KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL – Cody N. Rozeveld, Katherine M. Johnson, Lizhi Zhang and Gina L. Razidlo. https://cancerres.aacrjournals.org/content/80/22/4932

 

Nucleotides and folate



The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies – Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Dombret, Claude Preudhomme, Nina Fenouille, Lina Benajiba, Hava M. Golan, Kimberly Stegmaier, Camille Lobry, Kris C. Wood, Raphael Itzykson and Alexandre Puissant. https://cancerdiscovery.aacrjournals.org/content/10/12/1894
 
Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma – Jie Cai, Xuehua Sun, Han Guo, Xiaoye Qu, Hongting Huang, Chang Yu, Hailong Wu, Yueqiu Gao, Xiaoni Kong and Qiang Xia. https://www.nature.com/articles/s41389-020-00287-7

 

Mitochondria



Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability – Chen-Hua Chuang, Madeleine Dorsch, Philip Dujardin, Sukrit Silas, Kristina Ueffing, Johanna M Hölken, Dian Yang, Monte M Winslow  Barbara M Grüner. https://cancerres.aacrjournals.org/content/early/2020/11/25/0008-5472.CAN-20-1865
 
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import – Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri and Giulio Superti-Furga. https://www.nature.com/articles/s41467-020-19871-x
 
Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function – Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M. Bode and Zigang Dong. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00234-5

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study – Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM. https://www.nature.com/articles/s41418-020-00683-x
 


Starvation / Metabolic stress


Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate – Blake R. Wilde, Mohan R. Kaadige, Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm and Donald E. Ayer. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00233-6

PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability – Sandra M. Martín-Guerrero; Pedro Casado; Maruan Hijazi; Vinothini Rajeeve; Julio Plaza-Díaz; Francisco Abadía-Molina; Julio Navascués; Miguel A. Cuadros; Pedro R. Cutillas; David Martín-Oliva. https://portlandpress.com/biochemj/article-abstract/477/23/4491/226892

 

Hypoxia


Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types – Ana Miar, Esther Arnaiz, Esther Bridges, Shaunna Beedie, Adam P. Cribbs, Damien J. Downes, Robert A. Beagrie, Jan Rehwinkel and Adrian L. Harris. https://cancerres.aacrjournals.org/content/80/23/5245
 
 

IDH


Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment – Elavarasan Subramani, Marina Radoul, Chloe Najac, Georgios Batsios, Abigail R. Molloy, Donghyun Hong, Anne Marie Gillespie, Romelyn Delos Santos, Pavithra Viswanath, Joseph F. Costello, Russell O. Pieper and Sabrina M. Ronen. https://cancerres.aacrjournals.org/content/80/22
 
Inhibition of 2-Hydroxyglutarate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity in Mice – Padma Kadiyala, Stephen V. Carney, Jessica C. Gauss, Maria B. Garcia-Fabiani, Santiago Haase, Mahmoud S. Alghamri, Felipe J. Núñez, Yayuan Liu, Minzhi Yu, Ayman W. Taher, Fernando M. Nunez, Dan Li, Marta B. Edwards, Celina G. Kleer, Henry Appelman, Yilun Sun, Lili Zhao, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro. https://www.jci.org/articles/view/139542
 


Cancer Immunometabolism


Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity – Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker, Alessia  Catozzi, Juan C. García-Cañaveras, Brandon M. Gassaway, Brian C. Miller,  Vikram R. Juneja, Thao H. Nguyen, Shakchhi Joshi, Cong-Hui Yao, Haejin Yoon,  Peter T. Sage, Martin W. LaFleur, Justin D. Trombley, Connor A. Jacobson,  Zoltan Maliga, Steven P. Gygi, Peter K. Sorger, Joshua D. Rabinowitz, Arlene  H. Sharpe, Marcia C. Haigis. https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9
 
De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function – Ruohan Wu , Xuyong Chen, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Yufeng Yao, Lingling Liu, Gaofeng Fan, Mark R. Burns, Ruoning Wang. https://advances.sciencemag.org/content/6/51/eabc4275/tab-article-info
 
Lactate Limits T Cell Proliferation via the NAD(H) Redox State – William J. Quinn III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31489-3
 
The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies – Sruthy Varghese, Snigdha Pramanik, Leila J. Williams, Hannah R Hodges, Courtney W Hudgens, Grant M. Fischer, Catherine K Luo, Barbara Knighton, Lin Tan, Philip L. Lorenzi, Andrew L. MacKinnon, Jennifer L. McQuade, Yared Hailemichael, Jason Roszik, Weiyi Peng and Y.N. Vashisht Gopal. https://mct.aacrjournals.org/content/early/2020/12/23/1535-7163.MCT-20-0430.long
 


Miscellaneous


3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis – Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30693-6

The Associations of Aspirin, Statins, and Metformin With Lung Cancer Risk and Related Mortality: A Time-Dependent Analysis of Population-Based Nationally Representative Data – Jihun Kang, Su-Min Jeong, Dong Wook Shin, Mihee Cho, Jong Ho Cho, Jehun Kim. https://www.jto.org/article/S1556-0864(20)30712-7/fulltext
 


Reviews


Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy – Sarah-Maria Fendt, Christian Frezza and Ayelet Erez. https://cancerdiscovery.aacrjournals.org/content/10/12/1797

The Bidirectional Relationship Between Cancer Epigenetics and Metabolism – Luke T. Izzo, Hayley C. Affronti, and Kathryn E. Wellen. Annual Review of Cancer Biology. https://www.annualreviews.org/doi/abs/10.1146/annurev-cancerbio-070820-035832

Crosstalk between mechanotransduction and metabolism – Patrizia Romani, Lorea Valcarcel-Jimenez, Christian Frezza and Sirio Dupont. https://www.nature.com/articles/s41580-020-00306-w

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases – Sanjeethan C. Baksh, Lydia W.S. Finley. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30190-2

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance – Belisario, D.C.; Kopecka, J.; Pasino, M.; Akman, M.; De Smaele, E.; Donadelli, M.; Riganti, C. https://www.mdpi.com/2073-4409/9/12/2598

The Metabolic Underpinnings of Ferroptosis – Jiashuo Zheng, Marcus Conrad. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30544-1

Iron: An Essential Element of Cancer Metabolism – Myriam Y. Hsu, Erica Mina, Antonella Roetto and Paolo E. Porporato. https://www.mdpi.com/2073-4409/9/12/2591

Fructose Metabolism in Cancer – Nils Krause and Andre Wegner. https://www.mdpi.com/2073-4409/9/12/2635

The p53 Pathway and Metabolism: The Tree That Hides the Forest – Airelle Lahalle, Matthieu Lacroix, Carlo De Blasio, Madi Y. Cissé, Laetitia K. Linaresand Laurent Le Cam. https://www.mdpi.com/2072-6694/13/1/133#abstract
 


Comments


Fighting for Fat: Gluttonous Tumors and Starved T Cells – Joshua H. Goodman, Anthony W. Ferrante Jr. https://www.cell.com/cell/fulltext/S0092-8674(20)31611-1

Mind your media – Shoval Lagziel, Eyal Gottlieb and Tomer Shlomi. https://www.nature.com/articles/s42255-020-00299-y

Tumor start‐up: mitochondrial fusion makes it happen – Ana R Rebelo, Marcia Garcez, Catarina CF Homem. https://www.embopress.org/doi/abs/10.15252/embj.2020106927

O-Mg! Lactate Drives Mg2+ Mobilization – Blake R. Wilde, Heather R. Christofk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30801-7

The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension – Warren L. Wu, Thales Papagiannakopoulos. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30800-5

One Metformin a Day, Keeps Lung Cancer Away! Or Does It? – Samira Shojaee, Patrick Nana-Sinkam. https://www.jto.org/article/S1556-0864(20)30811-X/fulltext

Neutrophils Provide Lipids to Metastatic Tumor Cells, Fueling Growthhttps://cancerdiscovery.aacrjournals.org/content/10/12/OF9

MetaboList – November 2020


Starvation/metabolism and translation


Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer – Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schneider, Michael E. Pacold, Alec C. Kimmelman. https://www.cell.com/cell/fulltext/S0092-8674(20)31322-2

Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors – Stefan Bresson, Vadim Shchepachev, Christos Spanos, Tomasz W. Turowski, Juri Rappsilber, David Tollervey. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30651-1

A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress – Adam M. Lamper, Rebecca H. Fleming, Kayla M. Ladd, Amy S. Y. Lee. https://science.sciencemag.org/content/370/6518/853

A translational program that suppresses metabolism to shield the genome – Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz and Stephen Lee. https://www.nature.com/articles/s41467-020-19602-2

eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis – Ruan H, Li X, Xu X, Leibowitz BJ, Tong J, Chen L, Ao L, Xing W, Luo J, Yu Y, Schoen RE, Sonenberg N, Lu X, Zhang L, Yu J. https://elifesciences.org/articles/60151

4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs – Khawla Alasad, Kai Voeltzke, Liron Levin, Guido Reifenberger, Gabriel Leprivier and Barak Rotblat. https://www.nature.com/articles/s41419-020-03182-6


Amino acid metabolism


Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway – Ian J. Restall, Orsolya Cseh, Laura M. Richards, Trevor J. Pugh, H. Artee Luchman and Samuel Weiss. https://cancerres.aacrjournals.org/content/early/2020/10/24/0008-5472.CAN-19-3923.long

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis – Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler and Juliane G. Bogner-Strauss. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00232-7

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity – Amani Bouzidi, Maria Chiara Magnifico, Alessandro Paiardini, Alberto Macone, Giovanna Boumis, Giorgio Giardina, Serena Rinaldo, Francesca Romana Liberati, Clotilde Lauro, Cristina Limatola, Chiara Lanzillotta, Antonella Tramutola, Marzia Perluigi, Gianluca Sgarbi, Giancarlo Solaini, Alessandra Baracca, Alessio Paone and Francesca Cutruzzolà. https://www.nature.com/articles/s41419-020-03215-0

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers – Yiqing Zhao, Xiujing Feng, Yicheng Chen, J. Eva Selfridge, Shashank Gorityala, Zhanwen Du, Janet M. Wang, Yujun Hao, Gino Cioffi, Ronald A. Conlon, Jill S. Barnholtz-Sloan, Joel Saltzman, Smitha S. Krishnamurthi, Shaveta Vinayak, Martina Veigl, Yan Xu, David L. Bajor, Sanford D. Markowitz, Neal J. Meropol, Jennifer R. Eads and Zhenghe Wang. https://cancerres.aacrjournals.org/content/80/21/4815


Glycolysis, glucosamines


The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer – Jiyeon Kim, Hyun Min Lee, Feng Cai, Bookyung Ko, Chendong Yang, Elizabeth L. Lieu, Nefertiti Muhammad, Shawn Rhyne, Kailong Li, Mohamed Haloul, Wen Gu, Brandon Faubert, Akash K. Kaushik, Ling Cai, Sahba Kasiri, Ummay Marriam, Kien Nham, Luc Girard, Hui Wang, Xiankai Sun, James Kim, John D. Minna, Keziban Unsal-Kacmaz and Ralph J. DeBerardinis. https://www.nature.com/articles/s42255-020-00316-0

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers – Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Victoria C. Yan, Yasaman Barekatain, Sunada Khadka, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Cong-Dat Pham, Kenisha Arthur, David Maxwell, Zhenghong Peng, Paul G. Leonard, Barbara Czako, Federica Pisaneschi, Pijus Mandal, Yuting Sun, Rafal Zielinski, Susana Castro Pando, Xiaobo Wang, Theresa Tran, Quanyu Xu, Qi Wu, Yongying Jiang, Zhijun Kang, John M. Asara, Waldemar Priebe, William Bornmann, Joseph R. Marszalek, Ronald A. DePinho and Florian L. Muller. https://www.nature.com/articles/s42255-020-00313-3

Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target – Juliana C. Ferreira, Abdul-Rahman Khrbtli, Cameron Lee Shetler, Samman Mansoor, Liaqat Ali, Ozge Sensoy and Wael M. Rabeh. http://www.jbc.org/content/early/2020/11/13/jbc.RA120.015293.abstract

Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis – Keqiu Jiang, Chengyong Dong, Zeli Yin, Rui Li, Jiakai Mao, Chengye Wang, Junlin Zhang, Zhenming Gao, Rui Liang, Qi Wang and Liming Wang. https://www.nature.com/articles/s41419-020-03179-1


Lipid metabolism


Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis – Jonathan S. Rink, Adam Lin, Kaylin M. McMahon, Andrea E Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton and Leo I Gordon. http://www.jbc.org/content/early/2020/11/18/jbc.RA120.014888.abstract

ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway – Guohua Chen, Guoli Zhou, Aaron Lotvola, James G. Granneman and Jian Wang. http://www.jbc.org/content/early/2020/11/20/jbc.RA120.014682.abstract

The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial – Maria Feldt, Julien Menard, Ann H. Rosendahl, Barbara Lettiero, Pär-Ola Bendahl, Mattias Belting and Signe Borgquist. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00231-8


Mitochondria and mitochondrial stress


MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity – Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa and Masatoshi Nomura. https://www.nature.com/articles/s41467-020-19287-7

Anti-cancer strategy targeting the energy metabolism of tumor cells surviving a low-nutrient acidic microenvironment – Yuki Maeda, Ryota Kikuchi, Junichiro Kawagoe, Takao Tsuji, Nobuyuki Koyama, Kazuhiro Yamaguchi, Hiroyuki Nakamura, Kazutetsu Aoshiba. https://www.sciencedirect.com/science/article/pii/S2212877820301678


Starvation / nutrient sensing


Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation – Chan Lee, Lilian Lamech, Eleanor Johns, Michael Overholtzer. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30666-3

Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress – Huaiyuan Zhang, Yu Zhao, Qi Yao, Zijing Ye, Adriana Mañas, Jialing Xiang. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242700

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity – Yao Yao, Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A. MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30687-0

Rapid changes in the ATG5‐ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT) – Emily Crowley  Euphemia Leung  Jóhannes Reynisson  Alan Richardson. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15275


mTOR / AMPK


The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction – Shu Yang, Yingbiao Zhang, Chun-Yuan Ting, Lucia Bettedi, Kuikwon Kim, Elena Ghaniam, Mary A. Lilly. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30630-4

IQGAP1 binds AMPK and is required for maximum AMPK activation – Andrew C. Hedman, Zhigang Li, Laëtitia Gorisse, Swetha Parvathaneni, Chase J. Morgan and David B. Sacks. http://www.jbc.org/content/early/2020/11/15/jbc.RA120.016193.abstract


Hypoxia


p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen – Liz J. Valente; Amy Tarangelo; Albert Mao Li ; Marwan Naciri; Nitin Raj; Anthony M. Boutelle; Yang Li; Stephano Spano Mello ; Kathryn Bieging-Rolett; Ralph J. DeBerardinis; Jiangbin Ye; Scott J. Dixon; Laura D. Attardi. https://rupress.org/jcb/article/219/11/e201908212/152074

LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α – Linguo Xu, Lin Huan, Tianan Guo, Yangjun Wu, Yanfang Liu, Qifeng Wang, Shenglin Huang, Ye Xu, Linhui Liang and Xianghuo He. https://www.nature.com/articles/s41388-020-01512-8


Cancer Immunometabolism


Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity – Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30722-X

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy – Meixi Hao, Siyuan Hou, Weishuo Li, Kaiming Li, Lingjing Xue, Qifan Hu, Lulu Zhu, Yue Chen, Hongbin Sun, Caoyun Ju, Can Zhang. https://stm.sciencemag.org/content/12/571/eaaz6667

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy – Chia-Sing Lu, Ching-Wen Lin, Ya-Hsuan Chang, Hsuan-Yu Chen, Wei-Chia Chung2, Wei-Yun Lai, Chao-Chi Ho, Tong-Hong Wang, Chi-Yuan Chen, Chen-Lin Yeh, Sean Wu, Shu-Ping Wang and Pan-Chyr Yang. https://jitc.bmj.com/content/8/2/e001392


Miscellaneous


Treatment of glioblastoma multiforme with “classic” 4:1 ketogenic diet total meal replacement – Pavel Klein, Ivana Tyrlikova, Giulio Zuccoli, Adam Tyrlik and Joseph C. Maroon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00230-9

Downregulation of Keap1 Confers Features of a Fasted Metabolic State – Elena V Knatko, Michael H Tatham, Ying Zhang, Cecilia Castro, Maureen Higgins, Sharadha Dayalan Naidu, Chiara Leonardi, Laureano de la Vega, Tadashi Honda, Julian L Griffin, Ronald T Hay, Albena T Dinkova-Kostova. https://www.cell.com/iscience/fulltext/S2589-0042(20)30830-0


Reviews


Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy – Weimin Wang, Weiping Zou. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30614-6

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer – DeBlasi JM, DeNicola GM. https://pubmed.ncbi.nlm.nih.gov/33080927/

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment – Lara P. Fernández, Marta Gómez de Cedrón, and Ana Ramírez de Molina. https://www.frontiersin.org/articles/10.3389/fonc.2020.577420/full

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation – Tashbib Khan, Mitchell A. Sullivan, Jennifer H. Gunter, Thomas Kryza, Nicholas Lyons, Yaowu He, and John D. Hooper. https://www.frontiersin.org/articles/10.3389/fonc.2020.592455/full

Metabolic heterogeneity in cancer: An overview and therapeutic implications – Yu Tong, Wei-Qiang Gao, Yanfeng Liu. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20301402

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors – Marjolein M.G. Kes, Jan Van den Bossche, Arjan W. Griffioen, Elisabeth J.M. Huijbers. https://www.sciencedirect.com/science/article/pii/S0304419X20301463

2-Oxoglutarate-dependent dioxygenases in cancer – Julie-Aurore Losman, Peppi Koivunen and William G. Kaelin Jr. https://www.nature.com/articles/s41568-020-00303-3

A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer – Kodama M, Nakayama KI.. https://onlinelibrary.wiley.com/doi/10.1002/bies.202000169

Current biomarker-associated procedures of cancer modeling-a reference in the context of IDH1 mutant glioma – Narges Zare Mehrjardi, Daniel Hänggi and Ulf Dietrich Kahlert. https://www.nature.com/articles/s41419-020-03196-0

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy – Michaël Cerezo and Stéphane Rocchi. https://www.nature.com/articles/s41419-020-03175-5


Comments


A Tug-of-War Over Methionine – Ke Xu, Amy Shyu, Ming O. Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30549-0

Aldolase deployed for surveilling glucose – Sheng-Cai Lin. https://www.nature.com/articles/s41580-020-00305-x

Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux – Maria I. Matias, Valérie Dardalhon, Naomi Taylor. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30783-8

The metabolic foibles of triple negative breast cancer – Emily J. Gallagher. https://stm.sciencemag.org/content/12/571/eabf7102

In PDAC, “bad” cholesterol is good – Leslie K. Ferrarelli. https://stke.sciencemag.org/content/13/657/eabf5642

Metabolic benefits of mitochondrial DNA mutations – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-00309-x

Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming – Ana M.Urbano. https://www.sciencedirect.com/science/article/pii/S0925443920303136

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The 4th edition of Cancer and Metabolism symposium – Bordeaux area, France, May 27-29th 2021 will address key questions on human tumors nutrition and metabolism. Special guest: Sir Peter J. Ratcliffe, Nobel co-Laureate in 2019. http://www.canceropole-gso.org/?p=calendrier&id=1905&mod=evenement_consulter

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For more weekly updates on papers on Glutamine metabolism follow  Sreeparna Banerjee (https://twitter.com/sreeparna_b)

For more weekly papers on mitochondrial bioenergetics and cancer follow Kelsey Fisher-Wellman (https://twitter.com/KFW_Lab) (and @Frezzalab of course)

MetaboList – October 2020


Amino acid metabolism


Serine restriction alters sphingolipid diversity to constrain tumour growth – Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani Gengatharan, Antonio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace, Alan Saghatelian and Christian M. Metallo. https://www.nature.com/articles/s41586-020-2609-x

Polyamine pathway activity promotes cysteine essentiality in cancer cells – Tong Zhang, Christin Bauer, Alice C. Newman, Alejandro Huerta Uribe, Dimitris Athineos, Karen Blyth and Oliver D. K. Maddocks. https://www.nature.com/articles/s42255-020-0253-2

Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells – Rohiverth Guarecuco , Robert T. Williams, Lou Baudrier, Konnor La, Maria C. Passarelli, Naz Ekizoglu, Mert Mestanoglu, Hanan Alwaseem, Bety Rostandy, Justine Fidelin, Javier Garcia-Bermudez, Henrik Molina, Kivanç Birsoy. https://advances.sciencemag.org/content/6/41/eabc7120

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer – Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards. https://elifesciences.org/articles/56749

Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers – Yao-An Shen, Jiaxin Hong, Ryoichi Asaka, Shiho Asaka, Fang-Chi Hsu, Yohan Suryo Rahmanto, Jin-Gyoung Jung, Yu-Wei Chen, Ting-Tai Yen, Alicja Tomaszewski, Cissy Zhang, Nabeel Attarwala, Angelo M. DeMarzo, Ben Davidson, Chi-Mu Chuang, Xi Chen, Stephanie Gaillard, Anne Le, Ie-Ming Shih and Tian-Li Wang. https://cancerres.aacrjournals.org/content/80/20/4514

Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting – Hawley E Kunz, Jessica M Dorschner, Taylor E Berent, Thomas Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar and Ian R. Lanza. http://www.jbc.org/content/early/2020/10/01/jbc.RA120.014884.abstract


Glucose metabolism


Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle – Shiyu Liu, Ziwei Dai, Daniel E Cooper, David G Kirsch, Jason W Locasale. https://www.sciencedirect.com/science/article/abs/pii/S1550413120304836

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma – Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31282-1

Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation – Suparno Nandi, Mortezaali Razzaghi, Dhiraj Srivastava and Mishtu Dey. http://www.jbc.org/content/early/2020/09/28/jbc.RA120.015800.abstract

Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer – Bei Li, Qian Yang, Zhiyu Li, Zhiliang Xu, Si Sun, Qi Wu, and Shengrong Sun. https://www.frontiersin.org/articles/10.3389/fonc.2020.574787/full

Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer – Jiyoung Kim, Jengmin Kang, Ye-Lim Kang, Jongmin Woo, Youngsoo Kim, June Huh and Jong-Wan Park. https://www.nature.com/articles/s41467-020-19263-1


Lipid metabolism


Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase – Angela Maria Savino, Sara Isabel Fernandes, Orianne Olivares, Anna Zemlyansky, Antony Cousins, Elke K. Markert, Shani Barel, Ifat Geron, Liron Frishman, Yehudit Birger, Cornelia Eckert, Sergey Tumanov, Gillian MacKay, Jurre J. Kamphorst, Pawel Herzyk, Jonatan Fernández-García, Ifat Abramovich, Inbal Mor, Michela Bardini, Ersilia Barin, Sudha Janaki-Raman, Justin R. Cross, Michael G. Kharas, Eyal Gottlieb, Shai Izraeli and Christina Halsey. https://www.nature.com/articles/s43018-020-00115-2

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer – Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri, Janusz Franco-Barraza, Diana Restifo, Nicole Weitz, Charline Ogier, Aaron R. Goldman, Tiffiney R. Hartman, Ralph Francescone, Yinfei Tan, Emmanuelle Nicolas, Neelima Shah, Elizabeth A. Handorf, Kathy Q. Cai, Alana M. O’Reilly, Ido Sloma, Rachel Chiaverelli, Richard A. Moffitt, Vladimir Khazak, Carolyn Y. Fang, Erica A. Golemis, Edna Cukierman, Igor Astsaturov. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30426-8

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype – Virginia Lope, Ángel Guerrero-Zotano, Ana Casas, José Manuel Baena-Cañada, Begoña Bermejo, Beatriz Pérez-Gómez, Inmaculada Criado-Navarro, Silvia Antolín, Pedro Sánchez-Rovira, Manuel Ramos-Vázquez, Antonio Antón, Adela Castelló, José Ángel García-Saénz, Montserrat Muñoz, Ana de Juan, Raquel Andrés, Antonio Llombart-Cussac, Blanca Hernando, Rosa María Franquesa, Rosalia Caballero, Feliciano Priego-Capote, Miguel Martín and Marina Pollán. https://www.mdpi.com/2072-6643/12/10/3132

Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem–Like Cells and Reduces Metastases through Effects on Lipid Anabolism – Rosanna Dattilo, Carla Mottini, Emanuela Camera, Alessia Lamolinara, Noam Auslander, Ginevra Doglioni, Michela Muscolini, Wei Tang, Melanie Planque, Cristiana Ercolani, Simonetta Buglioni, Isabella Manni, Daniela Trisciuoglio, Alessandra Boe, Sveva Grande, Anna Maria Luciani, Manuela Iezzi, Gennaro Ciliberto, Stefan Ambs, Ruggero De Maria, Sarah-Maria Fendt, Eytan Ruppin and Luca Cardone. https://cancerres.aacrjournals.org/content/80/19/4087


Mitochondria and nucleotides


MCART1/SLC25A51 is required for mitochondrial NAD transport – Nora Kory, Jelmi uit de Bos, Sanne van der Rijt, Nevena Jankovic, Miriam Güra, Nicholas Arp, Izabella A. Pena, Gyan Prakash, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini. https://advances.sciencemag.org/content/early/2020/09/08/sciadv.abe5310

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis – Zhen Cai, Chien-Feng Li, Fei Han, Chunfang Liu, Anmei Zhang, Che-Chia Hsu, Danni Peng, Xian Zhang, Guoxiang Jin, Abdol-Hossein Rezaeian, Guihua Wang, Weina Zhang, Bo-Syong Pan, Chi-Yun Wang, Yu-Hui Wang, Shih-Ying Wu, Shun-Chin Yang, Fang-Chi Hsu, Ralph B. D’Agostino Jr., Christina M. Furdui, Gregory L. Kucera, John S. Parks, Floyd H. Chilton, Chih-Yang Huang, Fuu-Jen Tsai, Boris Pasche, Kounosuke Watabe, Hui-Kuan Lin. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30648-1

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells – Sandra Valle, Sonia Alcalá, Laura Martin-Hijano, Pablo Cabezas-Sáinz, Diego Navarro, Edurne Ramos Muñoz, Lourdes Yuste, Kanishka Tiwary, Karolin Walter, Laura Ruiz-Cañas, Marta Alonso-Nocelo, Juan A. Rubiolo, Emilio González-Arnay, Christopher Heeschen, Laura Garcia-Bermejo, Patrick C. Hermann, Laura Sánchez, Patricia Sancho, Miguel Ángel Fernández-Moreno and Bruno Sainz Jr. https://www.nature.com/articles/s41467-020-18954-z

Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis – Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom and Laura C. Greaves. https://www.nature.com/articles/s43018-020-00112-5

Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma – Yu Qian, Xiao Liang, Pengzhou Kong, Yikun Cheng, Heyang Cui, Ting Yan, Jinghao Wang, Ling Zhang, Yiqian Liu, Shiping Guo, Xiaolong Cheng and Yongping Cui. https://www.nature.com/articles/s41419-020-03044-1


Starvation and metabolic stress


Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation – Chan Lee, Lilian Lamech, Eleanor Johns, Michael Overholtzer. https://www.sciencedirect.com/science/article/abs/pii/S1534580720306663

Metabolic control of acclimation to nutrient deprivation dependent on polyphosphate synthesis – Sanz-Luque , S. Saroussi, W. Huang, N. Akkawi, A. R. Grossman. https://advances.sciencemag.org/content/6/40/eabb5351

Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism – Alexander I. May, Mark Prescott and Yoshinori Ohsumi. https://www.nature.com/articles/s41467-020-18805-x

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition – Takefumi Onodera, Isao Momose, Hayamitsu Adachi, Yohko Yamazaki, Ryuichi Sawa, Shun-ichi Ohba and Manabu Kawada. http://www.jbc.org/content/early/2020/09/25/jbc.RA120.013893.abstract


Nutrient sensing / AMPK


The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids – Geoffrey G. Hesketh, Fotini Papazotos, Judy Pawling, Dushyandi Rajendran, James D. R. Knight, Sebastien Martinez, Mikko Taipale, Daniel Schramek, James W. Dennis, Anne-Claude Gingras. https://science.sciencemag.org/content/370/6514/351

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation – Steffi Heidenreich, Pamela Weber, Heike Stephanowitz, Konstantin M. Petricek, Till Schütte, Moritz Oster, Antti M. Salo, Miriam Knauer, Isabel Goehring, Na Yang, Nicole Witte, Anne Schumann, Manuela Sommerfeld, Matthias Muenzner, Johanna Myllyharju, Eberhard Krause and Michael Schupp. http://www.jbc.org/content/early/2020/10/06/jbc.RA120.014402.abstract

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking – Maria Casas, Rut Fadó, José Luis Domínguez, Aina Roig, Moena Kaku, Shigeru Chohnan, Montse Solé, Mercedes Unzeta, Alfredo Jesús Miñano-Molina, José Rodríguez-Álvarez, Eamonn James Dickson, Núria Casals. https://rupress.org/jcb/article/219/10/e201912045/152088

AMP-independent activator of AMPK for treatment of mitochondrial disorders – Tereza Moore, Rolando E Yanes, Melissa A Calton, Douglas Vollrath, Gregory M Enns, Tina M Cowan. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240517


Hypoxia


Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer – Kate E.R. Hollinshead, Seth J. Parker, Vinay V. Eapen, Joel Encarnacion-Rosado, Albert Sohn, Tugba Oncu, Michael Cammer, Joseph D. Mancias, Alec C. Kimmelman. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31220-1

Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment – Irene Bertolini, Jagadish C. Ghosh, Andrew V. Kossenkov, Sudheer Mulugu, Shiv Ram Krishn, Valentina Vaira, Jun Qin, Edward F. Plow, Lucia R. Languino, Dario C. Altieri. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30588-8

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia – Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian H. Heidel, Tina M. Schnöder, Spasenija Savic Prince, Lukas Bubendorf, Paolo Pinton, Ralph A. Schmid, Johanna Baumgartner, Stefan Freigang, Sabina A. Berezowska, Alessandro Rimessi and Georgia Konstantinidou. https://www.nature.com/articles/s41556-020-00592-8


IDH


Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition – Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert and Mioara Larion. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00229-2

Poly(ADP-ribose) Glycohydrolase Inhibition Sequesters NAD+ to Potentiate the Metabolic Lethality of Alkylating Chemotherapy in IDH-Mutant Tumor Cells – Hiroaki Nagashima, Christine K. Lee, Kensuke Tateishi, Fumi Higuchi, Megha Subramanian, Seamus Rafferty, Lisa Melamed, Julie J. Miller, Hiroaki Wakimoto and Daniel P. Cahill. https://cancerdiscovery.aacrjournals.org/content/10/11/1672  


Cancer Immunometabolism


Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells – Valentí Gómez , Thomas R. Eykyn, Rami Mustapha, Fabián Flores-Borja, Victoria Male, Paul R. Barber, Antonia Patsialou, Ryan Green, Fani Panagaki, Chun W. Li, Gilbert O. Fruhwirth, Susana Ros, Kevin M. Brindle, Tony Ng. https://stke.sciencemag.org/content/13/652/eaax4585

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis – Peishan Li, Ming Lu, Jiayuan Shi, Zheng Gong, Li Hua, Qing Li, Bora Lim, Xiang H.-F. Zhang, Xiaowen Chen, Sheng Li, Leonard D. Shultz and Guangwen Ren. https://www.nature.com/articles/s41590-020-0783-5


Metabolic inhibitors


5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation – Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers and Kang-Yell Choi. https://www.nature.com/articles/s41467-020-19173-2

Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma – Qinchao Hu, Jianmin Peng, Laibo Jiang, Wuguo Li, Qiao Su, Jiayu Zhang, Huan Li, Ming Song, Bin Cheng, Juan Xia and Tong Wu. https://www.nature.com/articles/s41419-020-03126-0


Miscellaneous


Probing single-cell metabolism reveals prognostic value of highly metabolically active circulating stromal cells in prostate cancer – Francesca Rivello , Kinga Matula, Aigars Piruska, Minke Smits, Niven Mehra, Wilhelm T. S. Huck. https://advances.sciencemag.org/content/6/40/eaaz3849

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense – Marta Bosch Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocío Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M. Templin, James E. B. Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A. Del Pozo, Matthew J. Sweet, Patricia T. Bozza, Steven P. Gross, Robert G. Parton, Albert Pol. https://science.sciencemag.org/content/370/6514/eaay8085

Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins – J.J. Hulmi, F. Penna, N. Pöllänen, T.A. Nissinen, J. Hentilä, L. Euro, J.H. Lautaoja, R. Ballarò, R. Soliymani, M. Baumann, O. Ritvos, E. Pirinen, M. Lalowski. https://www.sciencedirect.com/science/article/pii/S2212877820301204

Macrophage-derived glutamine boosts satellite cells and muscle regeneration – Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien De Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquière, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi and Massimiliano Mazzone. https://www.nature.com/articles/s41586-020-2857-9

Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling – Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo, Marco Vanoni, Christian M. Metallo, Rosa Maria Moresco and Lilia Alberghina. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00227-4


Reviews


Immunometabolic Interplay in the Tumor Microenvironment – Irem Kaymak, Kelsey S. Williams, Jason R. Cantor, Russell G. Jones. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30478-5#.X5r5lrvYA_U

The Janus-like role of proline metabolism in cancer – Lynsey Burke, Inna Guterman, Raquel Palacios Gallego, Robert G. Britton, Daniel Burschowsky, Cristina Tufarelli and Alessandro Rufini. https://www.nature.com/articles/s41420-020-00341-8

Filament formation by metabolic enzymes—A new twist on regulation – Eric M. Lynch, Justin M. Kollman, Bradley A. Webb. https://www.sciencedirect.com/science/article/abs/pii/S0955067420300521

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology – J. Kierans  C. T. Taylor. https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280572

Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy – Stephen M. Hatfield and Michail V. Sitkovsky. https://www.jci.org/articles/view/137554

Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth – Birkeland ES, Koch LM, Dechant R. https://www.frontiersin.org/articles/10.3389/fonc.2020.01561/full

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors – Marjolein M G Kes, Jan Van den Bossche, Arjan W Griffioen, Elisabeth J M Huijbers. https://www.sciencedirect.com/science/article/pii/S0304419X20301463?via%3Dihub

Metabolic compartmentalization at the leading edge of metastatic cancer cells – Kara Wolfe, Ryo Kamata, Kester Coutinho, Takanari Inoue and Atsuo T. Sasaki. https://www.frontiersin.org/articles/10.3389/fonc.2020.554272/abstract

Targeting the HIF2–VEGF axis in renal cell carcinoma – Toni K. Choueiri and William G. Kaelin Jr. https://www.nature.com/articles/s41591-020-1093-z

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity – Emma U. Hammarlund, Emily Flashman, Sofie Mohlin, Francesco Licausi. https://science.sciencemag.org/content/370/6515/eaba3512

Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies – Ruiyuan Xu, Jinshou Yang, Bo Ren, Huanyu Wang, Gang Yang, Yuan Chen, Lei You, and Yupei Zhao. https://www.frontiersin.org/articles/10.3389/fonc.2020.572722/full

Multifaceted role of branched-chain amino acid metabolism in cancer – Hui Peng, Yingfei Wang and Weibo Luo. https://www.nature.com/articles/s41388-020-01480-z

Metabolic rivalry: circadian homeostasis and tumorigenesis – Kenichiro Kinouchi and Paolo Sassone-Corsi. https://www.nature.com/articles/s41568-020-0291-9

Targeting EMT in Cancer with Repurposed Metabolic Inhibitors – Vignesh Ramesh, Thomas Brabletz, Paolo Ceppi. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30189-8

Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer – Zhaodong Ji, Yan Shen, Xu Feng, Yue Kong, Yang Shao, Jiao Meng, Xiaofei Zhang, and Gong Yang. https://www.frontiersin.org/articles/10.3389/fonc.2020.593017/full

Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function – Ariel Igal, Débora I.Sinner. https://www.sciencedirect.com/science/article/abs/pii/S1388198120302328

Editorial: Metabolic Plasticity of Cancer – Sara Rodríguez-Enríquez, Tuuli Kaambre, and Rafael Moreno-Sánchez. https://www.frontiersin.org/articles/10.3389/fonc.2020.607511/full

Editorial: Metabolism Meets Function: Untangling the Cross-Talk Between Signaling and Metabolism – Alessandra Castegna, Daniel W. McVicar, Paolo E. Porporato, Annalisa Campanella, Erika M. Palmieri, and Alessio Menga. https://www.frontiersin.org/articles/10.3389/fonc.2020.607511/full

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer – Ellen C. de Heer, Mathilde Jalving, and Adrian L. Harris. https://www.jci.org/articles/view/137552

Quantitative Fluxomics of Circulating Metabolites – Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa, Xiaoxuan Li, Caroline Bartman, Zhaoyue Zhang, Cholsoon Jang, Lin Wang, Wenyun Lu, Jennifer Rojas, Joseph Baur, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30371-5

TCA cycle signalling and the evolution of eukaryotes – Dylan G Ryan, Christian Frezza, Luke AJ O’Neill. https://www.sciencedirect.com/science/article/abs/pii/S0958166920301440


Comments


Free Asparagine or Die: Cancer Cells Require Proteasomal Protein Breakdown to Survive Asparagine Depletion – Kristian Davidsen and Lucas B. Sullivan. https://cancerdiscovery.aacrjournals.org/content/10/11/1632

The smell of death and deCYStiny: polyamines play the hero – Joseph A. Combs and Gina M. DeNicola. https://www.nature.com/articles/s42255-020-0260-3

Hitting Gliomas When They Are Down: Exploiting IDH-Mutant Metabolic Vulnerabilities – Christopher J. Pirozzi and Hai Yan. https://cancerdiscovery.aacrjournals.org/content/10/11/1629

Metabolic ageing drives tumour progression – Ulrike Harjes. https://www.nature.com/articles/s41568-020-00301-5

Immortalizing switch to OXPHOS – Paulina Strzyz. https://www.nature.com/articles/s41580-020-00301-1

Serine Restriction Alters Sphingolipid Synthesis to Lower Tumor Growth. https://cancerdiscovery.aacrjournals.org/content/10/10/1440.2

Relapse-Driving AML Cells Exhibit Pyrimidine-Synthesis Dependency. https://cancerdiscovery.aacrjournals.org/content/10/10/1438.2

Fasting May Complement Endocrine Therapy. https://cancerdiscovery.aacrjournals.org/content/10/11/1617.2

Tumor Cells Deplete Methionine via SLC43A2, Causing T-cell Dysfunction. https://cancerdiscovery.aacrjournals.org/content/10/11/1623.2

Metabolic Adaptation to Lymphoma Suppresses NK-Cell Antitumor Function. https://cancerdiscovery.aacrjournals.org/content/10/11/1621.2


Paolo Sassone-Corsi (1956–2020) – Eric Verdin. https://science.sciencemag.org/content/370/6516/532

Paolo Sassone-Corsi (1956–2020) – Selma Masri, Colin R. Goding, Todd Leff. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30481-2

MetaboList – September 2020


Amino acid metabolism


Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition – Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley and Michael E. Pacold. https://cancerdiscovery.aacrjournals.org/content/10/9/1352

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance – Nick van Gastel, Jessica B. Spinelli, Azeem Sharda, Amir Schajnovitz, Ninib Baryawno, Catherine Rhee, Toshihiko Oki, Eliane Grace, Heather J. Soled, Jelena Milosevic, David B. Sykes, Peggy P. Hsu, Matthew G. Vander Heiden, Charles Vidoudez, Sunia A. Trauger, Marcia C. Haigis, David T. Scadden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30367-3

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism – Ruoyan Xu, William Jones, Ewa Wilcz‐Villega, Ana SH Costa, Vinothini Rajeeve, Robert B Bentham, Kevin Bryson, Ai Nagano, Busra Yaman, Sheila Olendo Barasa, Yewei Wang, Claude Chelala, Pedro Cutillas, Gyorgy Szabadkai, Christian Frezza, Katiuscia Bianchi. https://www.embopress.org/doi/full/10.15252/embr.201948260

Cancer proteome and metabolite changes linked to SHMT2 – Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237981Systemic muscle wasting and coordinated tumour response drive tumourigenesis – Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets and Susumu Hirabayashi. https://www.nature.com/articles/s41467-020-18502-9

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth – Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran and Chuanyue Wu. https://www.nature.com/articles/s41467-020-18753-6


Lipid metabolism


Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer – Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash and Timothy C. Thompson. https://www.nature.com/articles/s41467-020-17645-z

Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction – Manish Chamoli, Anita Goyala, Syed Shamsh Tabrez, Atif Ahmed Siddiqui, Anupama Singh, Adam Antebi, Gordon J. Lithgow, Jennifer L. Watts and Arnab Mukhopadhyay. https://www.nature.com/articles/s41467-020-18690-4


Nucleotides and NAD/PH


Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors – Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S. Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-wei Shen, Nir Peled, Igor Ulitsky, Angel Porgador, Eytan Ruppin and Ayelet Erez. https://www.nature.com/articles/s43018-020-0106-7

Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism – Muskan Bhatia, Jyotika Thakur, Shradha Suyal, Ruchika Oniel, Rahul Chakraborty, Shalini Pradhan, Monika Sharma, Shantanu Sengupta, Sunil Laxman, Shyam Kumar Masakapalli and Anand Kumar Bachhawat. http://www.jbc.org/content/early/2020/09/15/jbc.RA120.015129.abstract

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma – Anna E. Gibson, Choh Yeung, Sameer H. Issaq, Victor J. Collins, Michael Gouzoulis, Yiping Zhang, Jiuping Ji, Arnulfo Mendoza and Christine M. Heske. https://www.nature.com/articles/s41389-020-00264-0


Glucose metabolism


Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis – Jonathan M. Ghergurovich, Mark Esposito, Zihong Chen, Joshua Z. Wang, Vrushank Bhatt, Taijin Lan, Eileen White, Yibin Kang, Jessie Yanxiang Guo and Joshua D. Rabinowitz. https://cancerres.aacrjournals.org/content/80/18/3820

Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane – Yi Rao, Seth Gammon, Niki M. Zacharias, Tracy Liu, Travis Salzillo, Yuanxin Xi, Jing Wang, Pratip Bhattacharya, and David Piwnica-Worms. https://www.pnas.org/content/117/36/22378.abstract?etoc


Mitochondria


A Cellular Mechanism to Detect and Alleviate Reductive Stress – Andrew G. Manford, Fernando Rodríguez-Pérez, Karen Y. Shih, Zhuo Shi, Charles A. Berdan, Mangyu Choe, Denis V. Titov, Daniel K. Nomura, Michael Rape. https://www.cell.com/cell/fulltext/S0092-8674(20)31076-X

Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction – Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, Benjamin Olenchock, Eugene Rhee, Andrew M. Intlekofer, Othon Iliopoulos, Edward Chouchani and Jing-Ruey Joanna Yeh. https://cancerres.aacrjournals.org/content/80/17/3492 

Metabolic rewiring in drug resistant cells exhibit higher OXPHOS and fatty acids as preferred major source to cellular energetics – Sameer Salunkhe, Saket V. Mishra, Atanu Ghorai, Aarti Hole, Pratik Chandrani, Amit Dutt, Murali Chilakapati, Shilpee Dutt. https://www.sciencedirect.com/science/article/pii/S000527282030150X 

SLC25A51 is a mammalian mitochondrial NAD+ transporter – Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne and Joseph A. Baur. https://www.nature.com/articles/s41586-020-2741-7


Starvation


Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis – Bryan King, Jingwen Araki, Wilhelm Palm and Craig B. Thompson. http://genesdev.cshlp.org/content/34/19-20/1345.abstract?etoc

GADD34 is a modulator of autophagy during starvation – Gennaro Gambardella , Leopoldo Staiano, Maria Nicoletta Moretti, Rossella De Cegli, Luca Fagnocchi, Giuseppe Di Tullio, Sara Polletti, Clarissa Braccia, Andrea Armirotti, Alessio Zippo, Andrea Ballabio, Maria Antonietta De Matteis, Diego di Bernardo. https://advances.sciencemag.org/content/6/39/eabb0205

Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming – Caitlyn B. Brashears, Meltem Barlin, William R. Ehrhardt, Richa Rathore, Matthew Schultze, Shin-Chen Tzeng, Brian A. Van Tine and Jason M. Held. https://www.nature.com/articles/s41419-020-02899-8

Differential regulation of autophagy during metabolic stress in astrocytes and neurons – Aditi Kulkarni, Audrey Dong, Vineet Vinay Kulkarni, Jessica Chen, Olivia Laxton, Anip Anand and Sandra Maday. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1703354

Amino acid starvation inhibits autophagy in lipid droplet-deficient cells through mitochondrial dysfunction – Pierre Voisin, Marianne Bernard, Thierry Bergès, Matthieu Régnacq. https://portlandpress.com/biochemj/article-abstract/477/18/3613/226330


mTOR / AMPK


Phosphorylated Acetyl-CoA Carboxylase Is Associated with Clinical Benefit with Regorafenib in Relapsed Glioblastoma: REGOMA Trial Biomarker Analysis – Stefano Indraccolo, Gian Luca De Salvo, Martina Verza, Mario Caccese, Giovanni Esposito, Ilaria Piga, Paola Del Bianco, Marco Pizzi, Marina Paola Gardiman, Marica Eoli, Roberta Rudà, Alba Ariela Brandes, Toni Ibrahim, Simona Rizzato, Ivan Lolli, Vittorina Zagonel and Giuseppe Lombardi. https://clincancerres.aacrjournals.org/content/26/17/4478

Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling – Eleanor C. Warren, Stephanie Dooves, Eleonora Lugarà, Joseph Damstra-Oddy, Judith Schaf, Vivi M. Heine, Mathew C. Walker, and Robin S. B. Williams. https://www.pnas.org/content/117/38/23617.abstract?etoc

Cell death induced by dorsomorphin in adult T‐cell leukemia/lymphoma is AMPK‐independent – Akiyoshi Aikawa, Tomohiro Kozako, Yuichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Takeo Ohsugi, Shin‐ichiro Honda. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15239

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway – Erica De Zan , Ruud van Stiphout, Bianca V. Gapp, Vincent A. Blomen, Thijn R. Brummelkamp, Sebastian M.B. Nijman. https://stke.sciencemag.org/content/13/649/eaba5665 


IDH


Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells – Yi Xu, Yang Zhang, Juan C. García-Cañaveras, Lili Guo, Mengyuan Kan, Sixiang Yu, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang. https://science.sciencemag.org/content/369/6502/397/

Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma – Risheng Yang, Yuanlin Zhao, Yu Gu, Ying Yang, Xing Gao, Yuan Yuan, Liming Xiao, Jin Zhang, Chao Sun, Han Yang, Junhui Qin, Jing Li, Feng Zhang, Lijun Zhang and Jing Ye. https://www.nature.com/articles/s41388-020-01439-0 


Cancer Immunometabolism


Cancer SLC43A2 alters T cell methionine metabolism and histone methylation – Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Zeribe C. Nwosu, Li Zhang, Arkadiusz Czerwonka, Anna Pawłowska, Houjun Xia, Jing Li, Peng Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Rebecca Liu, Karen McLean, Marcin Cieslik, Arul M. Chinnaiyan, Witold Zgodziński, Grzegorz Wallner, Iwona Wertel, Karolina Okła, Ilona Kryczek, Costas A. Lyssiotis and Weiping Zou. https://www.nature.com/articles/s41586-020-2682-1

Seven-Gene Signature Based on Glycolysis Is Closely Related to the Prognosis and Tumor Immune Infiltration of Patients With Gastric Cancer – Shanshan Yu, Chuan Hu, Luya Cai, Xuedan Du, Fan Lin, Qiongjie Yu, Lixiao Liu, Cheng Zhang, Xuan Liu, Wenfeng Li, and Yu Zhan. https://www.frontiersin.org/articles/10.3389/fonc.2020.01778 


Metformin


AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation – Jeanine L. Van Nostrand, Kristina Hellberg, En-Ching Luo, Eric L. Van Nostrand, Alina Dayn, Jingting Yu, Maxim N. Shokhirev, Yelena Dayn, Gene W. Yeo and Reuben J. Shaw. http://genesdev.cshlp.org/content/34/19-20/1330.abstract?eto

Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial – Shuhong Wang, Yusheng Lin, Xiao Xiong, Lu Wang, Yi Guo, Yuping Chen, Shaobin Chen, Geng Wang, Peng Lin, Hongcai Chen, Sai-Ching Jim Yeung, Edwin Bremer and Hao Zhang. https://clincancerres.aacrjournals.org/content/26/18/4921

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways – Huairui Yuan, Ying Han, Xuege Wang, Ni Li, Qiuli Liu, Yuye Yin, Hanling Wang, Lulu Pan, Li Li, Kun Song, Tong Qiu, Qiang Pan, Qilong Chen, Guoying Zhang, Yi Zang, Minjia Tan, Jian Zhang, Qintong Li, Xiaoming Wang, Jun Jiang, Jun Qin. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30272-5


Miscellaneous


Age-induced accumulation of methylmalonic acid promotes tumour progression – Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt and John Blenis. https://www.nature.com/articles/s41586-020-2630-0

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas – Chan Chung, Stefan R. Sweha, Drew Pratt, Benita Tamrazi, Pooja Panwalkar, Adam Banda, Jill Bayliss, Debra Hawes, Fusheng Yang, Ho-Joon Lee, Mengrou Shan, Marcin Cieslik, Tingting Qin, Christian K. Werner, Daniel R. Wahl, Costas A. Lyssiotis, Zhiguo Bian, J. Brad Shotwell, Viveka Nand Yadav, Carl Koschmann, Arul M. Chinnaiyan, Stefan Blüml, Alexander R. Judkins, Sriram Venneti. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30369-X

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts – Wen-Chih Lee, Xing Ji, Itzhak Nissim, Fanxin Long. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31097-4

Defining the ATPome reveals cross-optimization of metabolic pathways – Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. https://www.nature.com/articles/s41467-020-18084-6

Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways – Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia and Jinglin Xia. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00225-6

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia – Martin Benej, Eliska Svastova, Radivojka Banova, Juraj Kopacek, Adriana Gibadulinova, Nicholas C. Denko, Martin Kery, Simona Arena, Andrea Scaloni, Monica Vitale, Nicola Zambrano, Ioanna Papandreou, and Silvia Pastorekova. https://www.frontiersin.org/articles/10.3389/fonc.2020.01462/full


Reviews


Mitochondrial Metabolism as a Target for Cancer Therapy – Karthik Vasan, Marie Werner, Navdeep S. Chandel. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30320-X

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take – Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt. https://www.embopress.org/doi/abs/10.15252/embr.202050635

Amino Assets: How Amino Acids Support Immunity – Beth Kelly, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30311-9 

Oxygen‐sensing mechanisms in cells – James W. Wilson, Dilem Shakir, Michael Batie, Mark Frost, Sonia Rocha. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15374 

If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease – Ffion R. Hammond, Amy Lewis, Philip M. Elks. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15476

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms – Clotilde Laussel, Sébastien Léon. https://www.sciencedirect.com/science/article/pii/S0006295220304494

Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis – Tao Jiang, Guangji Zhang and Zhaohuan Lou. https://www.frontiersin.org/articles/10.3389/fonc.2020.01788/full 

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications – Qinyao Wei, Yun Qian, Jun Yu and Chi Chun Wong. https://www.nature.com/articles/s41388-020-01432-7

Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring – Mariafrancesca Scalise, Lara Console, Filomena Rovella, Michele Galluccio, Lorena Pochini and Cesare Indiveri. https://www.mdpi.com/2073-4409/9/9/2028

Glutamine reliance in cell metabolism – Hee Chan Yoo, Ya Chun Yu, Yulseung Sung and Jung Min Han. https://www.nature.com/articles/s12276-020-00504-8

Metabolic Reprogramming is a Hallmark of Metabolism Itself – Miguel Ángel Medina. https://onlinelibrary.wiley.com/doi/10.1002/bies.202000058


Comments / other


Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation – Sharanya Sivanand and Matthew G. Vander Heiden. http://genesdev.cshlp.org/content/34/19-20/1253.abstract?etoc 

Cancer cells stock up in lymph vessels to survive – Barbara M. Grüner, Sarah-Maria Fendt. https://www.nature.com/articles/d41586-020-02383-5

ASS1igning purine dependency to cancer – Elodie Villa & Issam Ben-Sahra. https://www.nature.com/articles/s43018-020-00117-0

AMPK as a direct sensor of long-chain fatty acyl–CoA esters – D. Grahame Hardie. https://www.nature.com/articles/s42255-020-0249-y

Microenvironmental Aspartate Preserves Leukemic Cells from Therapy-Induced Metabolic Collapse – Lucille Stuani, Jean-Emmanuel Sarry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30421-6

An Antibody Attack against Body Wasting in Cancer – Maria Rohm, Stephan Herzig. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30416-2

Mitochondrial Oxidation of Ubiquinol Is Required for Tumorigenesishttps://cancerdiscovery.aacrjournals.org/content/10/9/1250.1


Paolo Sassone-Corsi (1956–2020) – Selma Masri, Colin R. Goding, Todd Leff. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30608-0

A tribute to Beth Levine (1960–2020) – Ralph J. DeBerardinis. https://www.jci.org/articles/view/142454


ISCaM 7th Annual Meeting Webinar Series, with focus on Systemic Metabolism and Cancer.

  • Systemic Metabolism and Cancer 1: Cancer Therapy and Diet. 20 October, 2020, 4pm. Karen Vousden, Valter D Longo, Jason W Locasale, Almut Schulze, 
  • Systemic Metabolism and Cancer 2: The Tumour Microenvironment. 27 October, 2020, 4pm. Jean-Ehrland Ricci, Katiuscia Bianchi, Kathrin Renner 

Direct access: https://drive.google.com/file/d/1On-B0W74p6BgZpEDX1JqQChm_dVbcifo/view?usp=sharing

EMBO Workshop: Cancer Immunometabolism

Organizers: Cristina Muñoz-Pinedo, Jean-Ehrland Ricci, Eric Eldering

Sitges (Barcelona), Spain, March 15-17 2021

https://meetings.embo.org/event/21-cancer

MetaboList – August 2020


Amino acids


Serine restriction alters sphingolipid diversity to constrain tumour growth – Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani Gengatharan, Antonio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace, Alan Saghatelian and Christian M. Metallo. https://www.nature.com/articles/s41586-020-2609-x

Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis – Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31006-8

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway – Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan and Jeffrey A. Moscow. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00214-9

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model – Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N. Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, François Vallette, Woo-Ping Ge, François Paris, Ralph J. DeBerardinis and Claire Pecqueur. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00215-8

Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours – Ziwen Zhu, Abhinav Achreja, Noah Meurs, Olamide Animasahun, Sarah Owen, Anjali Mittal, Pooja Parikh, Ting-Wen Lo, Janusz Franco-Barraza, Jiaqi Shi, Valerie Gunchick, Mara H. Sherman, Edna Cukierman, Andrew M. Pickering, Anirban Maitra, Vaibhav Sahai, Meredith A. Morgan, Sunitha Nagrath, Theodore S. Lawrence and Deepak Nagrath. https://www.nature.com/articles/s42255-020-0226-5


Glucose metabolism


HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors – Kangjing Xu, Zhongyuan He, Ming Chen, Nuofan Wang, Diancai Zhang, Li Yang, Zekuan Xu and Hao Xu. https://www.nature.com/articles/s41419-020-02768-4

p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis – Fang Wang, Xiao-Mei Qi, Ryan Wertz, Matthew Mortensen, Catherine Hagen, John Evans, Yuri Sheinin, Michael James, Pengyuan Liu, Susan Tsai, James Thomas, Alexander Mackinnon, Michael Dwinell, Charles R. Myers, Ramon Bartrons Bach, Liwu Fu and Guan Chen. https://cancerres.aacrjournals.org/content/80/16/3251

Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer – Elisabeth Smolle, Petra Leko, Elvira Stacher‐Priehse, Luka Brcic, Amin El‐Heliebi, Lilli Hofmann, Franz Quehenberger, Andelko Hrzenjak, Helmut H. Popper, Horst Olschewski, Katharina Leithner. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12780


Lipid metabolism


Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress – Xiang Cheng, Feng Geng, Meixia Pan, Xiaoning Wu, Yaogang Zhong, Chunyan Wang, Zhihua Tian, Chunming Cheng, Rui Zhang, Vinay Puduvalli, Craig Horbinski, Xiaokui Mo, Xianlin Han, Arnab Chakravarti, Deliang Guo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30303-X

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites – Claudie Bosc, Nicolas Broin, Marjorie Fanjul, Estelle Saland, Thomas Farge, Charly Courdy, Aurélie Batut, Rawand Masoud, Clément Larrue, Sarah Skuli, Nicolas Espagnolle, Jean-Christophe Pagès, Alice Carrier, Frédéric Bost, Justine Bertrand-Michel, Jérôme Tamburini, Christian Récher, Sarah Bertoli, Véronique Mansat-De Mas, Stéphane Manenti, Jean-Emmanuel Sarry and Carine Joffre. https://www.nature.com/articles/s41467-020-17882-2

Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression – Ji Hye Yang, Nam Hee Kim, Jun Seop Yun, Eunae Sandra Cho, Yong Hoon Cha, Sue Bean Cho, Seon-Hyeong Lee, So Young Cha, Soo-Youl Kim, Jiwon Choi, Tin-Tin Manh Nguyen, Sunghyouk Park, Hyun Sil Kim and Jong In Yook. https://www.life-science-alliance.org/content/3/7/e202000683.abstract

Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells – James Drury, Piotr G. Rychahou, Daheng He, Naser Jafari, Yekaterina Y. Zaytseva, Chi Wang, Eun Y. Lee, Heidi L. Weiss, and Bernard Mark Evers. https://www.frontiersin.org/articles/10.3389/fonc.2020.01185/full


Nucleotides


Purine metabolism regulates DNA repair and therapy resistance in glioblastoma – Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis and Daniel R. Wahl. https://www.nature.com/articles/s41467-020-17512-x

New regulatory mechanism‐based inhibitors of aspartate transcarbamoylase for potential anticancer drug development – Zhen Lei, Biying Wang, Zhifang Lu, Nan Wang, Hongwei Tan, Jimin Zheng, Zongchao Jia. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15220

Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage – Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31062-7


Mitochondria


Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria – Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter. https://elifesciences.org/articles/58041

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression – Yotaro Kudo, Masayuki Sugimoto, Esperanza Arias, Hiroaki Kasashima, Thekla Cordes, Juan F. Linares, Angeles Duran, Yuki Nakanishi, Naoko Nakanishi, Antoine L’Hermitte, Alex Campos, Nadia Senni, Tarmo Rooslid, Lewis R. Roberts, Ana Maria Cuervo, Christian M. Metallo, Michael Karin, Maria T. Diaz-Meco, Jorge Moscat. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30268-3

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex – Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza and James A. Nathan. https://www.nature.com/articles/s41467-020-17862-6

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite – Minervo Perez, Daniel W. Bak, Sarah E. Bergholtz, Daniel R Crooks, Bhargav Srinivas Arimilli, Youfeng Yang, Eranthie Weerapana, W. Marston Linehan and Jordan L. Meier. http://www.jbc.org/content/early/2020/08/19/jbc.AC120.014993.abstract

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition – Alba Roca-Portoles, Giovanny Rodriguez-Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian M. Mackay, Katelyn O’Neill, Leandro Lemgruber, Xu Luo & Stephen W. G. Tait. https://www.nature.com/articles/s41419-020-02867-2


Starvation


p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth – Ada Nowosad, Pauline Jeannot, Caroline Callot, Justine Creff, Renaud Thierry Perchey, Carine Joffre, Patrice Codogno, Stephane Manenti and Arnaud Besson. https://www.nature.com/articles/s41556-020-0554-4

Glutamine deprivation alters the origin and function of cancer cell exosomes – Shih‐Jung Fan, Benjamin Kroeger, Pauline P Marie, Esther M Bridges, John D Mason, Kristie McCormick, Christos E Zois, Helen Sheldon, Nasullah Khalid Alham, Errin Johnson, Matthew Ellis, Maria Irina Stefana, Cláudia C Mendes, Stephen Mark Wainwright, Christopher Cunningham, Freddie C Hamdy, John F Morris, Adrian L Harris, Clive Wilson, Deborah CI Goberdhan. https://www.embopress.org/doi/full/10.15252/embj.2019103009


Hypoxia


Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment – Irene Bertolini. Jagadish C. Ghosh. Andrew V. Kossenkov. Sudheer Mulugu. Shiv Ram Krishn. Valentina Vaira. Jun Qin. Edward F. Plow. Lucia R. Languino. Dario C. Altieri. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30588-8

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice – Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries and Ian J. Frew. https://www.nature.com/articles/s41467-020-17873-3


Miscellaneous


Lymph protects metastasizing melanoma cells from ferroptosis – Jessalyn M. Ubellacker, Alpaslan Tasdogan, Vijayashree Ramesh, Bo Shen, Evann C. Mitchell, Misty S. Martin-Sandoval, Zhimin Gu, Michael L. McCormick, Alison B. Durham, Douglas R. Spitz, Zhiyu Zhao, Thomas P. Mathews and Sean J. Morrison. https://www.nature.com/articles/s41586-020-2623-z

Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin – Ramy Ayoub, Rebecca M. Ruddy, Elizabeth Cox, Adeoye Oyefiade, Daniel Derkach, Suzanne Laughlin, Benjamin Ades-aron, Zahra Shirzadi, Els Fieremans, Bradley J. MacIntosh, Cynthia B. de Medeiros, Jovanka Skocic, Eric Bouffet, Freda D. Miller, Cindi M. Morshead and Donald J. Mabbott. https://www.nature.com/articles/s41591-020-0985-2

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice – Rowena Suriben, Michael Chen, Jared Higbee, Julie Oeffinger, Richard Ventura, Betty Li, Kalyani Mondal, Zhengyu Gao, Dina Ayupova, Pranali Taskar, Diana Li, Shelley R. Starck, Hung-I Harry Chen, Michele McEntee, Subhash D. Katewa, Van Phung, Marilyn Wang, Avantika Kekatpure, Damodharan Lakshminarasimhan, Andre White, Andrea Olland, Raj Haldankar, Mark J. Solloway, Jer-Yuan Hsu, Yan Wang, Jie Tang, Darrin A. Lindhout and Bernard B. Allan. https://www.nature.com/articles/s41591-020-0945-x

In situ Metabolic Profiling of Ovarian Cancer Tumor Xenografts: A Digital Pathology Approach – Ilaria Piga, Martina Verza, Francesca Montenegro, Giorgia Nardo, Elisabetta Zulato, Tiziana Zanin, Paola Del Bianco, Giovanni Esposito and Stefano Indraccolo. https://www.frontiersin.org/articles/10.3389/fonc.2020.01277/full


Reviews


Lactate modulation of immune responses in inflammatory versus tumour microenvironments – Michelangelo Certo, Chin-Hsien Tsai, Valentina Pucino, Ping-Chih Ho and Claudio Mauro. https://www.nature.com/articles/s41577-020-0406-2

Glycolysis – a key player in the inflammatory response – Gonzalo Soto‐Heredero, Manuel M. Gómez de las Heras, Enrique Gabandé‐Rodríguez, Jorge Oller, María Mittelbrunn. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15327

Tracking the carbons supplying gluconeogenesis – Ankit M. Shah and Fredric E. Wondisford. http://www.jbc.org/content/early/2020/08/13/jbc.REV120.012758.abstract

Metabolism and the Epigenome: A Dynamic Relationship – Spencer A. Haws, Cassandra M. Leech, John M. Denu. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30092-X

Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks – Rachel J. Perry and Gerald I. Shulman. http://www.jbc.org/content/early/2020/08/12/jbc.REV120.008387.abstract

Metabolism of immune cells in cancer – Robert D. Leone and Jonathan D. Powell. https://www.nature.com/articles/s41568-020-0273-y

Endogenous toxic metabolites and implications in cancer therapy – Namgyu Lee, Meghan E. Spears, Anne E. Carlisle and Dohoon Kim. https://www.nature.com/articles/s41388-020-01395-9

Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth – Eivind Salmorin Birkeland, Lisa Maria Koch and Reinhard Dechant. https://www.frontiersin.org/articles/10.3389/fonc.2020.01561/full

Manipulation of Mitochondrial Plasticity Changes the Metabolic Competition Between “Foe” and “Friend” During Tumor Malignant Transformation – Hui Tian, Baofu Zhang, Liantao Li, Gang Wang, Huizhong Li and JunNian Zheng. https://www.frontiersin.org/articles/10.3389/fonc.2020.01692/full

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy – Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Daqing Zhao, Boyang Jason Wu and Xiangyan Li. https://www.frontiersin.org/articles/10.3389/fonc.2020.01510/full

The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation – Cyrielle L. Bouchez, Noureddine Hammad, Sylvain Cuvellier, Stéphane Ransac, Michel Rigoulet and Anne Devin. https://www.frontiersin.org/articles/10.3389/fonc.2020.01333/full

Oncology Therapeutics Targeting the Metabolism of Amino Acids – Muhammad N, Lee HM, Kim J. https://www.mdpi.com/2073-4409/9/8/1904

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions – Lavanya Ponnusamy, Sathan Raj Natarajan, Karthik Thangaraj, Ravi Manoharan. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20300986

Cholesterol metabolism: New functions and therapeutic approaches in cancer – Huanji Xu, Sheng Zhou, Qiulin Tang, Hongwei Xia, Feng Bi. https://www.sciencedirect.com/science/article/abs/pii/S0304419X2030113X

Inside the hypoxic tumour: reprogramming of the DDR and radioresistance – Katheryn Begg and Mahvash Tavassoli. https://www.nature.com/articles/s41420-020-00311-0


Comments


Give and take: competition for BCAAs in the tumour microenvironment – Russell E. Ericksen and Weiping Han. https://www.nature.com/articles/s42255-020-0239-0

PKCλ/ι Loss Induces Metabolic Reprogramming in Liver Cancer: Hitting Two Birds with One Stone? – Pierluigi Ramadori, Xin Li, Mathias Heikenwalder. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30364-0

Fasting-mimicking diet plus chemotherapy in breast cancer treatment – Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini and Filippo de Braud. https://www.nature.com/articles/s41467-020-18194-1

The IDH1 Inhibitor Ivosidenib May Slow IDH1-Mutant Glioma Progression – https://cancerdiscovery.aacrjournals.org/content/10/8/OF6

MetaboList – July 2020


Glucose sensing and metabolism


Dihydroxyacetone phosphate signals glucose availability to mTORC1 – Jose M. Orozco, Patrycja A. Krawczyk, Sonia M. Scaria, Andrew L. Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini. https://www.nature.com/articles/s42255-020-0250-5

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancerMaría Gutiérrez-Salmerón, José Manuel García-Martínez, Javier Martínez-Useros, María Jesús Fernández-Aceñero, Benoit Viollet, Severine Olivier, Jagat Chauhan, Silvia R. Lucena, Antonio De la Vieja, Colin R. Goding, Ana Chocarro-Calvo, Custodia García-Jiménez. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000732

Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways – Min Li, Xuxiao He, Weixing Guo, Hongming Yu, Shicheng Zhang, Ningning Wang, Guijun Liu, Rina Sa, Xia Shen, Yabo Jiang, Yufu Tang, Yujuan Zhuo, Chunzhao Yin, Qiaochu Tu, Nan Li, Xiaoqun Nie, Yu Li, Zhimin Hu, Hanwen Zhu, Jianping Ding, Zi Li, Te Liu, Fan Zhang, He Zhou, Shengxian Li, Jiang Yue, Zheng Yan, Shuqun Cheng, Yongzhen Tao and Huiyong Yin. https://www.nature.com/articles/s43018-020-0086-7

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells – M. Caillot, J. Bourgeais, H. Dakik, É. Costé, N. M. Mazure, É. Lelièvre, O. Coqueret, O. Hérault, F. Mazurier and B. Sola. https://www.nature.com/articles/s41389-020-00253-3


Amino acid metabolism


Extracellular serine controls epidermal stem cell fate and tumour initiation – Sanjeethan C. Baksh, Pavlina K. Todorova, Shiri Gur-Cohen, Brian Hurwitz, Yejing Ge, Jesse S. S. Novak, Matthew T. Tierney, June dela Cruz-Racelis, Elaine Fuchs and Lydia W. S. Finley. https://www.nature.com/articles/s41556-020-0525-9

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells – Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell. https://www.jci.org/articles/view/131859

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression – Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu and Qing-Bai She. https://www.nature.com/articles/s41467-020-17067-x

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth – Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman and Mei Kong. https://www.nature.com/articles/s41467-020-17181-w


Lipid sensing and metabolism


Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms – Stephen L. Pinkosky, John W. Scott, Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Rebecca J. Ford, Christopher G. Langendorf, Naomi X. Y. Ling, Tracy L. Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William. Smiles, Kevin R. W. Ngoei, Michael W. Parker, Yan Yan, Karsten Melcher, Bruce E. Kemp, Jonathan S. Oakhill and Gregory R. Steinberg. https://www.nature.com/articles/s42255-020-0245-2

De Novo Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma – Nima Abbassi-Ghadi, Stefan S. Antonowicz, James S. McKenzie, Sacheen Kumar, Juzheng Huang, Emrys A. Jones, Nicole Strittmatter, Gemma Petts, Hiromi Kudo, Stephen Court, Jonathan M. Hoare, Kirill Veselkov, Robert Goldin, Zoltán Takáts and George B. Hanna. https://cancerres.aacrjournals.org/content/80/13/2764


Mitochondria and hypoxia


Mitochondrial ubiquinol oxidation is necessary for tumour growth – Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S. McElroy, Marie Werner, Hermon Kihshen, Colleen R. Reczek, Samuel E. Weinberg, Peng Gao, Elizabeth M. Steinert, Raul Piseaux, G. R. Scott Budinger and Navdeep S. Chandel. https://www.nature.com/articles/s41586-020-2475-6

Na+ controls hypoxic signalling by the mitochondrial respiratory chainPablo Hernansanz-Agustín, Carmen Choya-Foces, Susana Carregal-Romero, Elena Ramos, Tamara Oliva, Tamara Villa-Piña, Laura Moreno, Alicia Izquierdo-Álvarez, J. Daniel Cabrera-García, Ana Cortés, Ana Victoria Lechuga-Vieco, Pooja Jadiya, Elisa Navarro, Esther Parada, Alejandra Palomino-Antolín, Daniel Tello, Rebeca Acín-Pérez, Juan Carlos Rodríguez-Aguilera, Plácido Navas, Ángel Cogolludo, Iván López-Montero, Álvaro Martínez-del-Pozo, Javier Egea, Manuela G. López, John W. Elrod, Jesús Ruíz-Cabello, Anna Bogdanova, José Antonio Enríquez and Antonio Martínez-Ruiz. https://www.nature.com/articles/s41586-020-2551-y

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells – Jie Li , Ekta Agarwal, Irene Bertolini, Jae Ho Seo, M. Cecilia Caino, Jagadish C. Ghosh, Andrew V. Kossenkov, Qin Liu, Hsin-Yao Tang, Aaron R. Goldman, Lucia R. Languino, David W. Speicher, Dario C. Altieri. https://stke.sciencemag.org/content/13/642/eaaz8240

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival – Cesar Cardenas , Alenka Lovy, Eduardo Silva-Pavez, Felix Urra, Craig Mizzoni, Ulises Ahumada-Castro, Galdo Bustos, Fabian Jaňa, Pablo Cruz, Paula Farias, Elizabeth Mendoza, Hernan Huerta, Paola Murgas, Martin Hunter, Melany Rios, Oscar Cerda, Irene Georgakoudi, Armen Zakarian, Jordi Molgó, J. Kevin Foskett. https://stke.sciencemag.org/content/13/640/eaay1212

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells by modulating metabolism and death pathways – J. Vial, P. Huchedé, S. Fagault, F. Basset, M. Rossi, J. Geoffray, H. Soldati, J. Bisaccia, M. H. Elsensohn, M. Creveaux, D. Neves, J. Y. Blay, F. Fauvelle, F. Bouquet, N. Streichenberger, N. Corradini, C. Bergeron, D. Maucort-Boulch, P. Castets, M. Carré, K. Weber and M. Castets. https://www.nature.com/articles/s41420-020-00302-1

Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth – L. M. Schiffmann, J. P. Werthenbach, F. Heintges-Kleinhofer, J. M. Seeger, M. Fritsch, S. D. Günther, S. Willenborg, S. Brodesser, C. Lucas, C. Jüngst, M. C. Albert, F. Schorn, A. Witt, C. T. Moraes, C. J. Bruns, M. Pasparakis, M. Krönke, S. A. Eming, O. Coutelle and H. Kashkar. https://www.nature.com/articles/s41467-020-17472-2

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells – Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00219-4


Starvation/metabolic stress


Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damageJoffrey Pelletier, Ferran Riaño‐Canalias, Eugènia Almacellas, Caroline Mauvezin, Sara Samino, Sonia Feu, Sandra Menoyo, Ana Domostegui, Marta Garcia‐Cajide, Ramon Salazar, Constanza Cortés, Ricard Marcos, Albert Tauler, Oscar Yanes, Neus Agell, Sara C Kozma, Antonio Gentilella, George Thomas. https://www.embopress.org/doi/full/10.15252/embj.2019103838

Systematic quantitative analysis of ribosome inventory during nutrient stress – Heeseon An, Alban Ordureau, Maria Körner, Joao A. Paulo and J. Wade Harper. https://www.nature.com/articles/s41586-020-2446-y

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress – Ahmad Kobiita, Svenja Godbersen, Elisa Araldi, Umesh Ghoshdastider, Marc W. Schmid, Giatgen Spinas, Holger Moch, Markus Stoffel. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30827-5


AMPK/mTOR


VRK-1 extends life span by activation of AMPK via phosphorylation – Sangsoon Park , Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, Seung-Jae V. Lee. https://advances.sciencemag.org/content/6/27/eaaw7824

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndromeGennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E. G. de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagnì, Pier Paolo Di Fiore, Lukas A. Huber and Andrea Ballabio. https://www.nature.com/articles/s41586-020-2444-0


Metabolic reprogramming (general)


Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma – Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden  . https://elifesciences.org/articles/56782

The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolismM. Carmen Lafita-Navarro, Lizbeth Perez-Castro, Lauren G. Zacharias, Spencer Barnes, Ralph J. DeBerardinis and Maralice Conacci-Sorrell. http://www.jbc.org/content/early/2020/07/01/jbc.AC120.014189.abstract 

Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells – Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova and Mónica Marín. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00216-7


Cancer Immunometabolism


An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells – Shogo Kumagai, Yosuke Togashi, Chika Sakai, Akihito Kawazoe, Masahito Kawazu, Toshihide Ueno, Eiichi Sato, Takeshi Kuwata, Takahiro Kinoshita, Masami Yamamoto, Sachiyo Nomura, Tetsuya Tsukamoto, Hiroyuki Mano, Kohei Shitara, Hiroyoshi Nishikawa. https://www.cell.com/immunity/fulltext/S1074-7613(20)30271-5

Tumors induce de novo steroid biosynthesis in T cells to evade immunity – Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields and Sarah A. Teichmann. https://www.nature.com/articles/s41467-020-17339-6

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells – Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell. https://www.jci.org/articles/view/131859


Methods


Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers – Andre Koit, Natalja Timohhina, Laura Truu, Vladimir Chekulayev, Shivakumar Gudlawar, Igor Shevchuk, Katrin Lepik, Lea Mallo, Riina Kutner, Vahur Valvere and Tuuli Kaambre. https://www.frontiersin.org/articles/10.3389/fonc.2020.01053/full

Metabolite AutoPlotter – an application to process and visualise metabolite data in the web browser – Matthias Pietzke and Alexei Vazquez. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00220-x


Miscellaneous


Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility – James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30861-5

Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscleCristina Sánchez‐González, Cristina Nuevo‐Tapioles, Juan Cruz Herrero Martín, Marta P Pereira, Sandra Serrano Sanz, Ana Ramírez de Molina, José M Cuezva, Laura Formentini. https://www.embopress.org/doi/full/10.15252/embj.2019103812

Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma – Anil R. Singh, Juan J. Gu, Qunling Zhang, Pallawi Torka, Suchitra Sundaram, Cory Mavis and Francisco J. Hernandez-Ilizaliturri. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00213-w


Reviews


Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments – Fuming Li, M. Celeste Simon. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30497-4

Lactate: the ugly duckling of energy metabolism – Joshua D. Rabinowitz and Sven Enerbäck. https://www.nature.com/articles/s42255-020-0243-4

Metabolite sensing and signaling in Cancer – Yi-Ping Wang, Jin-Tao Li, Jia Qu, Miao Yin and Qun-Ying Lei. http://www.jbc.org/content/early/2020/07/07/jbc.REV119.007624.abstract

Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer ImmunotherapyElisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo, Tomás Alarcón,Ruth Lupu, Joaquim Bosch-Barrera and Javier A. Menendez. https://www.mdpi.com/2072-6694/12/7/1757

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy? – Hannah J. Smith, Arpit Sharma, William B. Mair. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30461-5

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational ModificationsOscar A. Tarazona, Olivier Pourquié. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30543-8

Integration of Hippo-YAP Signaling with MetabolismConsuelo Ibar, Kenneth D. Irvine. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30504-9

The Lysosome at the Intersection of Cellular Growth and Destruction – Hijai R. Shin, Roberto Zoncu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30460-3

Fructose contributes to the Warburg effect for cancer growth – Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan and Richard J. Johnson. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00222-9

Mitochondrial Stress Response and Cancer – Jordan O’Malley, Rahul Kumar, Joseph Inigo, Nagendra Yadava, Dhyan Chandra. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30139-4

Metabolic Modulation of Immunity: A New Concept in Cancer ImmunotherapyLuana Guerra, Lynn Bonetti, Dirk Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30829-9


Comments


A spoonful of DHAP keeps mTORC1 running on sugars – Gerta Hoxhaj, Jason W. Locasale and Issam Ben-Sahra. https://www.nature.com/articles/s42255-020-0246-1

AMPK as a direct sensor of long-chain fatty acyl–CoA estersD. Grahame Hardie. https://www.nature.com/articles/s42255-020-0249-y

A ‘fast’er way to treat breast cancer – Marcus D. Goncalves and Lewis C. Cantley. https://www.nature.com/articles/s42255-020-0225-6

Starve a cold, and perhaps a cancer – Daniel Haensel and Anthony E. Oro. https://www.nature.com/articles/s41556-020-0543-7

Integrating serine with tumour initiation – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-0287-5