MetaboList – October 2018

Glucose metabolism, glycolytic enzymes

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals – Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Peder J. Lund, Mariana Lopes, Benjamin A. Garcia, Kathryn E. Wellen, David G. Kirsch and Jason W. Locasale.

Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells – Maria R. Depaoli, Felix Karsten, Corina T. Madreiter-Sokolowski, Christiane Klec, Benjamin Gottschalk, Helmut Bischof, Emrah Eroglu, Markus Waldeck-Weiermair, Thomas Simmen, Wolfgang F. Graier and Roland Malli.

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling – Michael J. Bollong, Gihoon Lee, John S. Coukos, Hwayoung Yun, Claudio Zambaldo, Jae Won Chang, Emily N. Chin, Insha Ahmad, Arnab K. Chatterjee, Luke L. Lairson, Peter G. Schultz and Raymond E. Moellering.

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells – Haobin Ye, Biniam Adane, Nabilah Khan, Erica Alexeev, Nichole Nusbacher, Mohammad Minhajuddin, Brett M. Stevens, Amanda C. Winters, Xi Lin, John M. Ashton, Enkhtsetseg Purev, Lianping Xing, Daniel A. Pollyea, Catherine A. Lozupone, Natalie J. Serkova, Sean P. Colgan and Craig T. Jordan.

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells – Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente and Didier Y. R. Stainier.

PKM2 is not required for pancreatic ductal adenocarcinoma – Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio and Matthew G Vander Heiden.

LDH and lactate

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism – Maša Ždralević, Almut Brand, Lorenza Di Ianni, Katja Dettmer, Jörg Reinders, Katrin Singer, Katrin Peter, Annette Schnell, Christina Bruss, Sonja-Maria Decking, Gudrun Koehl, Blanca Felipe-Abrio, Jérôme Durivault, Pascale Bayer, Marie Evangelista, Thomas O’Brien, Peter J. Oefner, Kathrin Renner, Jacques Pouysségur and Marina Kreutz.

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival – Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman and Ze’ev A Ronai.

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth – Yuan Liu, Ji-Zheng Guo, Ying Liu, Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu, Shengtao Zhou, Xiao-Chen Lu, Hong-Bin Yang, Chenyue Xu, Wei Gao, Li Zhou, Yi-Ping Wang, Weiguo Hu, Yuquan Wei, Canhua Huang and Qun-Ying Lei.

Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer – Teresa Eichenlaub, René Villadsen, Flávia C.P. Freitas, Diana Andrejeva, Blanca I. Aldana, Hung Than Nguyen, Ole William Petersen, Jan Gorodkin, Héctor Herranz and Stephen M. Cohen.

Amino acids / Redox / lipid metabolism

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze.

Biosynthetic energy cost for amino acids decreases in cancer evolution – Hong Zhang, Yirong Wang, Jun Li, Han Chen, Xionglei He, Huiwen Zhang, Han Liang and Jian Lu.

Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia – Lucille Stuani, Fabien Riols, Pierre Millard, Marie Sabatier, Aurélie Batut, Estelle Saland, Fanny Viars, Laure Tonini, Sonia Zaghdoudi, Laetitia K. Linares, Jean-Charles Portais, Jean-Emmanuel Sarry and Justine Bertrand-Michel.


Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer – Anthony Cheung, James Opzoomer, Kristina M. Ilieva, Patrycja Gazinska, Ricarda M. Hoffmann, Hasan Mirza, Rebecca Marlow, Erika Francesch-Domenech, Matthew Fittall, Diana Dominguez Rodriguez, Angela Clifford, Luned Badder, Nirmesh Patel, Silvia Mele, Giulia Pellizzari, Heather J. Bax, Silvia Crescioli, Gyula Petranyi, Daniel Larcombe-Young, Debra H. Josephs, Silvana Canevari, Mariangela Figini, Sarah Pinder, Frank O. Nestle, Cheryl Gillett, James F. Spicer, Anita Grigoriadis, Andrew N.J. Tutt and Sophia N. Karagiannis.

Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools – Svetlana A. Kholodar, Ananda K. Ghosh, Katarzyna Świderek, Vicent Moliner and Amnon Kohen.


Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism – Martin Benej, Xiangqian Hong, Sandip Vibhute, Sabina Scott, Jinghai Wu, Edward Graves, Quynh-Thu Le, Albert C. Koong, Amato J. Giaccia, Bing Yu, Shih-Ching Chen, Ioanna Papandreou and Nicholas C. Denko.

Cox2p of yeast cytochrome oxidase assembles as a stand-alone subunit with the Cox1p and Cox3p modules – Leticia Veloso R. Franco, Chen Hsien Su, Gavin P. McStay, George J. Yu and Alexander Tzagoloff.

Starvation / mTOR

Chronic starvation induces noncanonical pro-death stress granules – Lucas C. Reineke, Shebna A. Cheema, Julien Dubrulle and Joel R. Neilson.

The mTOR-S6 kinase pathway promotes stress granule assembly – Aristeidis P. Sfakianos, Laura E. Mellor, Yoke Fei Pang, Paraskevi Kritsiligkou, Hope Needs, Hussein Abou-Hamdan, Laurent Désaubry, Gino B. Poulin, Mark P. Ashe and Alan J. Whitmarsh.

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux – Wei Wan, Zhiyuan You, Li Zhou, Yinfeng Xu, Chao Peng, Tianhua Zhou, Cong Yi, Yin Shi and Wei Liu.

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction – Rituraj Pal, Michela Palmieri, Arindam Chaudhury, Tiemo Jürgen Klisch, Alberto di Ronza, Joel R. Neilson, George G. Rodney and Marco Sardiello.

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin – Maria A. Gubbiotti, Erin Seifert, Ulrich Rodeck, Jan B. Hoek and Renato V. Iozzo.

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia – Peter van Galen, Nathan Mbong, Antonia Kreso, Erwin M. Schoof, Elvin Wagenblast, Stanley W.K. Ng, Gabriela Krivdova, Liqing Jin, Hiromitsu Nakauchi and John E. Dick.


Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia – Arpita Chowdhury, Abhishek Aich, Gaurav Jain, Katharina Wozny, Christian Lüchtenborg, Magnus Hartmann, Olaf Bernhard, Martina Balleiniger, Ezzaldin Ahmed Alfar, Anke Zieseniss, Karl Toischer, Kaomei Guan, Silvio O. Rizzoli, Britta Brügger, Andrè Fischer, Dörthe M. Katschinski, Peter Rehling and Jan Dudek.

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury – Roman Vozdek , Yong Long and Dengke K. Ma.

MicroRNA expression profile during different conditions of hypoxia – Donato Lacedonia, Giulia Scioscia, Grazia Pia Palladino, Crescenzio Gallo, Giovanna Elisiana Carpagnano, Roberto Sabato and Maria Pia Foschino Barbaro.

Oxygen-Enhanced and Dynamic Contrast-Enhanced Optoacoustic Tomography Provide Surrogate Biomarkers of Tumor Vascular Function, Hypoxia, and Necrosis – Michal R. Tomaszewski, Marcel Gehrung, James Joseph, Isabel Quiros-Gonzalez, Jonathan A. Disselhorst and Sarah E. Bohndiek.

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment – Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu and Gregg L. Semenza.

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α – Susana Simões-Sousa, Samantha Littler, Sarah L. Thompson, Paul Minshall, Helen Whalley, Bjorn Bakker, Klaudyna Belkot, Daniela Moralli, Daniel Bronder, Anthony Tighe, Diana C.J. Spierings, Nourdine Bah, Joshua Graham, Louisa Nelson, Catherine M. Green, Floris Foijer, Paul A. Townsend and Stephen S. Taylor.

Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen – Mathieu Deygas, Rudy Gadet, Germain Gillet, Ruth Rimokh, Philippe Gonzalo and Ivan Mikaelian.


Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells – Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan and Christian M. Metallo.

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism – Mingzhu Bai, Linlin Yang, Hong Liao, Xiaoyan Liang, Bingying Xie, Ji Xiong, Xiang Tao, Xiong Chen, Yali Cheng, Xiaojun Chen, Youji Feng, Zhenbo Zhang and Wenxin Zheng.

IDH1R132H is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment – Patricia D. B. Tiburcio, Bing Xiao, Yi Chai, Sydney Asper, Sheryl R. Tripp, David L. Gillespie, Randy L. Jensen and L. Eric Huang.[]=26203&path[]=81692

Cancer immunometabolism

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity – Minkyung Song, Tito A. Sandoval, Chang-Suk Chae, Sahil Chopra, Chen Tan, Melanie R. Rutkowski, Mahesh Raundhal, Ricardo A. Chaurio, Kyle K. Payne, Csaba Konrad, Sarah E. Bettigole, Hee Rae Shin, Michael J. P. Crowley, Juan P. Cerliani, Andrew V. Kossenkov, Ievgen Motorykin, Sheng Zhang, Giovanni Manfredi, Dmitriy Zamarin, Kevin Holcomb, Paulo C. Rodriguez, Gabriel A. Rabinovich, Jose R. Conejo-Garcia, Laurie H. Glimcher and Juan R. Cubillos-Ruiz.


Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells – Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri Li, Matthew G. Vander Heiden, Mieke Dewerchin and Peter Carmeliet.

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State – Clair Crewe, Nolwenn Joffin, Joseph M. Rutkowski, Min Kim, Fang Zhang, Dwight A. Towler, Ruth Gordillo and Philipp E. Scherer.

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response – Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko and Natalia I. Krupenko.

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases – Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen and Poul Nissen.


Emerging Technologies to Image Tissue Metabolism – Vasilis Ntziachristos, Miguel A. Pleitez, Silvio Aime and Kevin M. Brindle.

Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis – Sara M. Nowinski, Jonathan G. Van Vranken, Katja K. Dove and Jared Rutter.

The Different Routes to Metastasis via Hypoxia-Regulated Programs – Ana Rita Nobre, David Entenberg, Yarong Wang, John Condeelis and Julio A. Aguirre-Ghiso.

Targeting the IDH2 Pathway in Acute Myeloid Leukemia – Maria L. Amaya and Daniel A. Pollyea.

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti and Jean-Ehrland Ricci.

Polyamine metabolism and cancer: treatments, challenges and opportunities – Robert A. Casero Jr, Tracy Murray Stewart and Anthony E. Pegg.

Fasting and cancer: molecular mechanisms and clinical application – Alessio Nencioni, Irene Caffa, Salvatore Cortellino and Valter D. Longo.

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer – Eugene W. Gerner, Elizabeth Bruckheimer and Alfred Cohen.

The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism – Giuseppe Biamonti, Lucia Maita and Alessandra Montecucco.

Mevalonate Metabolism in Cancer Stemness and Trained Immunity – Georg Gruenbacher and Martin Thurnher.

Roles of polyamines in translation – Thomas E. Dever and Ivaylo P. Ivanov.

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions – W. Kimryn Rathmell, Jeffrey C. Rathmell and W. Marston Linehan.

Cancer Metabolism: the Known, Unknowns – Dang CV.

Editorial for this issue of BBA-Reviews on cancer with many more interesting reviews:


AMPK Regulates the Epigenome through Phosphorylation of TET2 – Eleanor C. Fiedler and Reuben J. Shaw.

ATF4‐amino acid circuits: a recipe for resistance in melanoma – Mario R Fernandez and John L Cleveland.


Metabolic Signaling. Methods and Protocols

Editors: Sarah-Maria Fendt and Sophia Y. Lunt

Springer Protocols


MetaboList – September 2018


Glucose metabolism/glycolytic enzymes

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization – William J. Sullivan, Peter J. Mullen, Ernst W. Schmid, Aimee Flores, Milica Momcilovic, Mark S. Sharpley, David Jelinek, Andrew E. Whiteley, Matthew B. Maxwell, Blake R. Wilde, Utpal Banerjee, Hilary A. Coller, David B. Shackelford, Daniel Braas, Donald E. Ayer, Thomas Q. de Aguiar Vallim, William E. Lowry, Heather R. Christofk.

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis – Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Jian Li, William M. Oldham, Galina V. Beznoussenko, Alexander A. Mironov, Joseph Loscalzo & Victor W. Hsu.

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer – Xing-Yu Zhong, Xiu-Ming Yuan, Ying-Ying Xu, Miao Yin, Wei-Wei Yan, Shao-Wu Zou, Li-Ming Wei, Hao-Jie Lu, Yi-Ping Wang, Qun-Ying Lei.

Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation – Zhizhou Ye, Donald E. Ayer.

LncRNA–FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 Signaling – Zehua Bian, Jiwei Zhang, Min Li, Yuyang Feng, Xue Wang, Jia Zhang, Surui Yao, Guoying Jin, Jun Du, Weifeng Han, Yuan Yin, Shenglin Huang, Bojian Fei, Jian Zou and Zhaohui Huang.

Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma – Richard Mair, Alan J. Wright, Susana Ros, De-en Hu, Tom Booth, Felix Kreis, Jyotsna Rao, Colin Watts and Kevin M. Brindle.

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination – Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin & Thomas Helleday.

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer – Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou.


Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures – Joo Sang Lee, Lital Adler, Hiren Karathia, Narin Carmel, Shiran Rabinovich, Noam Auslander, Rom Keshet, Noa Stettner, Alon Silberman, Lilach Agemy, Daniel Helbling, Raya Eilam, Qin Sun, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Hila Weiss, Sivan Pinto, Shelly Kalaora, Ronen Levy, Eilon Barnea, Arie Admon, David Dimmock, Noam Stern-Ginossar, Avigdor Scherz, Sandesh C.S. Nagamani, Miguel Unda, David M. Wilson III, Ronit Elhasid, Arkaitz Carracedo, Yardena Samuels, Sridhar Hannenhalli, Eytan Ruppin, Ayelet Erez.

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers – Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis.

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase – Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai.

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation – Costas Koufaris and Roland Nilsson.

Amino acid metabolism

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis – Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijssel, Giorgio Saladino, Federico Comitani, Annalisa Zecchin, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns, Joris Souffreau, Luc Schoonjans, Wouter H. Lamers, Yi Wu, Jurgen Haustraete, Johan Hofkens, Sandra Liekens, Richard Cubbon, Bart Ghesquière, Mieke Dewerchin, Francesco L. Gervasio, Xuri Li, Jaap D. van Buul, Xu Wu & Peter Carmeliet.

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes – Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, William Boyle, Ankur Karmokar, Catherine Andreadi, Jin-Li Luo, David A. Moore, Maria Viskaduraki, Matthew Blades, Graeme I. Murray, Lynne M. Howells, Anne Thomas, Karen Brown, Paul N. Cheng & Alessandro Rufini.

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression – Xiangming Ji, Jun Qian, S. M. Jamshedur Rahman, Peter J. Siska, Yong Zou, Bradford K. Harris, Megan D. Hoeksema, Irina A. Trenary, Chen Heidi, Rosana Eisenberg, Jeffrey C. Rathmell, Jamey D. Young & Pierre P. Massion.

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation – Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A Cassel, Douglas R Green, Yusen Liu, Teresa WM Fan, Ruoning Wang.

Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer – Rong Zhou, Puneet Bagga, Kavindra Nath, Hari Hariharan, David A. Mankoff and Ravinder Reddy.

Redox metabolism/sensing

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma – Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin Jr.

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling – Ming Luo, Li Shang, Michael D. Brooks, Evelyn Jiagge, Yongyou Zhu, Johanna M. Buschhaus, Sarah Conley, Melissa A. Fath, April Davis, Elizabeth Gheordunescu, Yongfang Wang, Ramdane Harouaka, Ann Lozier, Daniel Triner, Sean McDermott, Sofia D. Merajver, Gary D. Luker, Douglas R. Spitz, Max S. Wicha.

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells – Suresh K. Joseph, Michael Young, Kamil Alzayady, David I. Yule, Mehboob Ali, David M. Booth and György Hajnóczky.

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly – Elizabeth C Hinchy, Anja V. Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R. Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling and Michael P. Murphy.

Lipid metabolism

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation – Daniel Ackerman, Sergey Tumanov, Bo Qiu, Evdokia Michalopoulou, Michelle Spata, Andrew Azzam, Hong Xie, M. Celeste Simon, Jurre J. Kamphorst.

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy – Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV.

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance – Hideki Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao.

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis – Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Brüning U, Scheinok S, Treps L, Cantelmo AR, Dubois C, de Zeeuw P,  Goveia J, Zecchin A, Taverna F, Morales-Rodriguez F, Brajic A, Conradi LC, Schoors S, Harjes U, Vriens K, Pilz GA, Chen R, Cubbon R, Thienpont B, Cruys B, Wong BW, Ghesquière B, Dewerchin M, De Bock K, Sagaert X, Jessberger S, Jones EAV, Gallez B, Lambrechts D, Mazzone M, Eelen G, Li X, Fendt SM, Carmeliet P.

Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult – Yuxiao Yao, Shaoyang Sun, Jingjing Wang, Fei Fei, Zhaoru Dong, Ai-Wu Ke, Ruoyu He, Lei Wang, Lili Zhang, Min-Biao Ji, Qiang Li, Min Yu, Guo-Ming Shi, Jia Fan, Zhiyuan Gong and Xu Wang.


Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer – Young Kyuen Im, Ouafa Najyb, Simon-Pierre Gravel, Shawn McGuirk, Ryuhjin Ahn, Daina Z. Avizonis, Valérie Chénard, Valerie Sabourin, Jesse Hudson, Tony Pawson, Ivan Topisirovic, Michael Pollak, Julie St-Pierre and Josie Ursini-Siegel.

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi.

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation – Timothy I. Johnson, Ana S. H. Costa, Ashley N. Ferguson & Christian Frezza.


Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase – Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek & Tracy G. Anthony.

Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy – Seda Avcioglu Barutcu, Nomeda Girnius, Santiago Vernia & Roger J. Davis.

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis – Helen Lin, Yiyin Chung, Chun-Ting Cheng, Ching Ouyang, Yong Fu, Ching-Ying Kuo, Kevin K. Chi, Maryam Sadeghi, Peiguo Chu, Hsing-Jien Kung, Chien-Feng Li, Kirsten H. Limesand & David K. Ann.

mTOR and nutrient sensing

Whi2 is a conserved negative regulator of TORC1 in response to low amino acids – Xianghui Chen, Guiqin Wang, Yu Zhang, Margaret Dayhoff-Brannigan, Nicola L. Diny, Mingjun Zhao, Ge He, Cierra N. Sing, Kyle A. Metz, Zachary D. Stolp, Abdel Aouacheria, Wen-Chih Cheng, J. Marie Hardwick, Xinchen Teng.

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells – Tra-Ly Nguyen, Marie-Julie Nokin, Maxim Egorov, Mercedes Tomé, Clément Bodineau, Carmelo Di Primo, Lætitia Minder, Joanna Wdzieczak-Bakala, Maria Concepcion Garcia-Alvarez, Jérôme Bignon, Odile Thoison, Bernard Delpech, Georgiana Surpateanu, Yves-Michel Frapart, Fabienne Peyrot, Kahina Abbas, Silvia Terés, Serge Evrard, Abdel-Majid Khatib, Pierre Soubeyran, Bogdan I. Iorga, Raúl V. Durán and Pascal Collin.

Phospholipase D-Dependent mTORC1 Activation by Glutamine – Elyssa Bernfeld, Deepak Menon, Vishaldeep Vaghela, Ismat Zerin, Promie Faruque, Maria A. Frias and David A. Foster.

mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation – Joseph G. Moloughney1, Nicole M. Vega-Cotto1, Sharon Liu1, Chadni Patel1,Peter K. Kim2, Chang-chih Wu1, Danielle Albaciete1, Cedric Magaway1,Austin Chang1, Swati Rajput1, Xiaoyang Su3, Guy Werlen1 and Estela Jacinto.

Drugs: metformin, etomoxir, 2-DG

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo – Anila K. Madiraju, Yang Qiu, Rachel J. Perry, Yasmeen Rahimi, Xian-Man Zhangn Dongyan Zhang, João-Paulo G. Camporez, Gary W. Cline, Gina M. Butrico, Bruce E. Kemp, Gregori Casals, Gregory R. Steinberg, Daniel F. Vatner, Kitt F. Petersen & Gerald I. Shulman.

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase – Roger W. Hunter, Curtis C. Hughey, Louise Lantier, Elias I. Sundelin, Mark Peggie, Elton Zeqiraj, Frank Sicheri, Niels Jessen, David H. Wasserman & Kei Sakamoto.

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis – Ajit S. Divakaruni, Wei Yuan Hsieh, Lucía Minarrieta, Tin N. Duong, Kristen K.O. Kim, Brandon R. Desousa, Alexander Y. Andreyev, Caitlyn E. Bowman, Kacey Caradonna, Brian P. Dranka, David A. Ferrick, Marc Liesa, Linsey Stiles, George W. Rogers, Daniel Braas, Theodore P. Ciaraldi, Michael J. Wolfgang, Tim Sparwasser, Luciana Berod, Steven J. Bensinger, Anne N. Murphy.

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation – Brenda Raud, Dominic G. Roy, Ajit S. Divakaruni, Tatyana N. Tarasenko, Raimo Franke, Eric H. Ma, Bozena Samborska, Wei Yuan Hsieh, Alison H. Wong, Philipp Stüve, Catharina Arnold-Schrauf, Melanie Guderian, Matthias Lochner, Shakuntala Rampertaap, Kimberly Romito, Joseph Monsale, Mark Brönstrup, Steven J. Bensinger, Anne N. Murphy, Peter J. McGuire, Russell G. Jones, Tim Sparwasser, Luciana Berod.

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation – Feilong Wang, Song Zhang, Ivan Vuckovic, Ryounghoon Jeon, Amir Lerman, Clifford D. Folmes, Petras P. Dzeja, Joerg Herrmann.

Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1 – Federico Lucantoni, Heiko Dussmann and Jochen H. M. Prehn.


Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions – Pedro Latorre-Muro, Josue Baeza, Eric A. Armstrong, Ramón Hurtado-Guerrero, Francisco Corzana, Lindsay E. Wu, David A. Sinclair, Pascual López-Buesa, José A. Carrodeguas, John M. Denu.

High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling – Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Maria Del Carmen Rodriguez Pena, Jennifer B. Gordetsky, Eiichi Morii, Kazutake Tsujikawa, George J. Netto and Norio Nonomura.

CD38 is methylated in prostate cancer and regulates extracellular NAD+ – Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan,Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja,David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell and Andrew S. Goldstein.

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP – Shuang Wei, Jie Wang, Olutobi Oyinlade, Ding Ma, Shuyan Wang, Lisa Kratz, Bachchu Lal, Qingfu Xu, Senquan Liu, Sagar R. Shah, Hao Zhang, Yunqing Li, Alfredo Quiñones-Hinojosa, Heng Zhu, Zhi-yong Huang, Linzhao Cheng, Jiang Qian & Shuli Xia.

Extracellular Citrate and Cancer Metabolism (Letter) – Philippe Icard, Ludovic Fournel, Marco Alifano and Hubert Lincet.

Extracellular Citrate and Cancer Metabolism (Response) – Maria E. Mycielska and Edward K. Geissler.


Nutrient Sensing in Cancer – Margaret E. Torrence and Brendan D. Manning.

Rewiring urea cycle metabolism in cancer to support anabolism – Rom Keshet, Peter Szlosarek, Arkaitz Carracedo & Ayelet Erez.

The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer – Sandrine Silvente-Poirot, Florence Dalenc and Marc Poirot.

Hidden features: exploring the non-canonical functions of metabolic enzymes – Peiwei Huangyang, M. Celeste Simon.

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy – Yueming Zhu, Angela Elizabeth Dean, Nobuo Horikoshi, Collin Heer, Douglas R. Spitz, and David Gius.

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger.

Amino acid transporters revisited: New views in health and disease – Palanivel Kandasamy, Gergely Gyimesi, Yoshikatsu Kanai, Matthias A. Hediger.

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism – Ramon Bartrons, Helga Simon-Molas, Ana Rodríguez-García, Esther Castaño, Àurea Navarro-Sabaté, Anna Manzano, and Ubaldo E. Martinez-Outschoorn.

Interplay between adenylate metabolizing enzymes and AMP‐activated protein kinase – Marcella Camici, Simone Allegrini, Maria Grazia Tozzi.

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation – Myung Hee Park1 and Edith C Wolff.


A Glycolysis Outsider Steps into the Cancer Spotlight – Marcus D. Goncalves, Lewis C. Cantley.

Metabolic Frugality Marks Cancer Cells for Immune Targeting – Lucas B. Sullivan.

The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation – Xiaoyan Zhang & Yanzhuang Wang.

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology – Michael V. Berridge, Carole Crasso & Jiri Neuzil.

Autophagy-deficient tumor cells rely on extracellular amino acids to survive upon glutamine deprivation – Nan Zhang, Xin Yang, Fengjie Yuan, Wei-Guo Zhu & Ying Zhao.

It takes two to tango: IDH mutation and glutaminase inhibition in glioma – Qing Zhang.

Excess Fumarate or Succinate Impairs Homologous Recombination

Hyperglycemia Results in TET2 Destabilization to Promote Tumorigenesis

IDH Mutations Suppress T Cell–Mediated Antitumor Immunity

Disrupting Histidine Catabolism Reduces Methotrexate Sensitivity

Epigenetic control by sugar

MetaboList – August 2018


Glucose metabolism / Lactate

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies – Maria Apicella, Elisa Giannoni, Stephany Fiore, Karin Johanna Ferrari, Daniel Fernández-Pérez, Claudio Isella, Carlotta Granchi, Filippo Minutolo, Antonino Sottile, Paolo Maria Comoglio, Enzo Medico, Filippo Pietrantonio, Marco Volante, Diego Pasini, Paola Chiarugi, Silvia Giordano, Simona Corso.

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo – Kevin D. Courtney, Divya Bezwada, Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Alexander M. Funk, Jennifer Wimberly, Sarah S. McNeil, Payal Kapur, Yair Lotan, Vitaly Margulis, Jeffrey A. Cadeddu, Ivan Pedrosa, Ralph J. DeBerardinis, Craig R. Malloy, Robert M. Bachoo, Elizabeth A. Maher.

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis – Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda, Ernst Lengyel.

Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism – Maša Ždralević, Almut Brand, Lorenza Di Ianni, Katja Dettmer, Jörg Reinders, Katrin Singer, Katrin Peter, Annette Schnell, Christina Bruss, Sonja-Maria Decking, Gudrun Koehl, Blanca Felipe-Abrio, Jérôme Durivault, Pascale Bayer, Marie Evangelista, Thomas O’Brien, Peter J. Oefner, Kathrin Renner, Jacques Pouysségur and Marina Kreutz.

GAPDH with NAD+-binding site mutation competitively inhibits the wild-type and affects glucose metabolism in cancer – Kunjithapatham R, Ganapathy-Kanniappan S.

O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1 – Hiroki Sekine, Keito Okazaki, Koichiro Kato, M. Morshedul Alam, Hiroki Shima, Fumiki Katsuoka, Tadayuki Tsujita, Norio Suzuki, Akira Kobayashi, Kazuhiko Igarashi, Masayuki Yamamoto, Hozumi Motohashi.

Amino acid metabolism

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting – Furkan Alkan, Katharina E. Walter, Alba Luengo, Corina T. Madreiter-Sokolowski, Sarah Stryeck, Allison N. Lau, Wael Al-Zoughbi, Caroline A. Lewis, Craig J. Thomas, Gerald Hoefler, Wolfgang F. Graier, Tobias Madl, Matthew G. Vander Heiden, Juliane G. Bogner-Strauss.

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 – Mylène Tajan, Andreas K. Hock, Julianna Blagih, Neil A. Robertson, Christiaan F. Labuschagne, Flore Kruiswijk, Timothy J. Humpton, Peter D. Adams, Karen H. Vousden.

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response – Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara, Yuka Hasegawa, Kosei Toyoshima, Yasuko Tsuchiya, Daisuke Tomita, Jun Fujimoto, Osamu Kurasawa, Chisato Takahara, Ayumi Ando, Ryuichi Nishigaki, Yoshinori Satomi, Akito Hata, and Takahito Hara.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis – Guy Eelen, Charlotte Dubois, […] Peter Carmeliet.

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang.

CARM1 suppresses de novo serine synthesis by promoting PKM2 activity – Tharindumala Abeywardana, Myungeun Oh, Lei Jiang, Ying Yang, Mei Kong, Jikui Song and Yanzhong Yang.

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis – Patrick Murphy, Michael A. Giacomantonio, Joao A. Paulo, Robert A. Everley, Barry E. Kennedy, Gopal P. Pathak, Derek R. Clements, Youra Kim, Cathleen Dai, Tanveer Sharif, Steven P. Gygi, Shashi Gujar.

Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment – Liang Wang, Wen Peng, Tianming Wu, Pengchi Deng & Ying-Lan Zhao.

Lipid metabolism

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins – Maomao Zhang, Julie S. Di Martino, Robert L. Bowman, Nathaniel R. Campbell, Sanjeethan C. Baksh, Theresa Simon-Vermot, Isabella S. Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R. Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E. Ariyan, Kivanç Birsoy, Jedd D. Wolchok, Katherine S. Panageas, Travis Hollmann, Jose Javier Bravo-Cordero and Richard M. White.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation – Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C.S. Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F. Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V. Swinnen, Jordan L. Meier, Rhushikesh A. Kulkarni, Albert Sickmann, Bart Ghesquière, Luc Schoonjans, Xuri Li, Massimiliano Mazzone, Peter Carmeliet.

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis – Seher Balaban Lisa S Lee Bianca Varney Atqiya Aishah Quanqing Gao Robert F Shearer Darren N Saunders Thomas Grewal Andrew J. Hoy.

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer – Viktor Brovkovych, Yasir Izhar, Jeanne M. Danes, Oleskii Dubrovskyi, Isin T. Sakallioglu, Lauren M. Morrow, G. Ekin Atilla-Gokcumen & Jonna Frasor.

Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC) – Yifan Kong, Lijun Cheng, Fengyi Mao, Zhuangzhuang Zhang, Yanquan Zhang, Elia Farah, Jacob Bosler, Yunfeng Bai, Nihal Ahmad, Shihuan Kuang, Lang Li and Xiaoqi Liu.


Metabolomic profiling of human lung tumor tissues: nucleotide metabolism as a candidate for therapeutic interventions and biomarkers – Paula Moreno, Carla Jiménez‐Jiménez, Martín Garrido‐Rodríguez, Mónica Calderón‐Santiago, Susana Molina, Maribel Lara‐Chica, Feliciano Priego‐Capote, Ángel Salvatierra, Eduardo Muñoz, Marco A Calzado.


Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi.

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency – Bocca C, Kane MS, Veyrat-Durebex C, Chupin S, Alban J, Kouassi Nzoughet J, Le Mao M, Chao de la Barca JM, Amati-Bonneau P, Bonneau D, Procaccio V, Lenaers G, Simard G, Chevrollier A, Reynier P.

p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells – Hidekazu Nagano, Naoko Hashimoto, Akitoshi Nakayama, Sawako Suzuki, Yui Miyabayashi, Azusa Yamato, Seiichiro Higuchi, Masanori Fujimoto, Ikki Sakuma, Minako Beppu, Masataka Yokoyama, Yutaka Suzuki, Sumio Sugano, Kazuhiro Ikeda, Ichiro Tatsuno, Ichiro Manabe, Koutaro Yokote, Satoshi Inoue, and Tomoaki Tanaka.

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly – Jonathan G. Van Vranken, Sara M. Nowinski, Katie J. Clowers, Mi-Young Jeong, Yeyun Ouyang, Jordan A. Berg, Jeremy P. Gygi, Steven P. Gygi, Dennis R. Winge, Jared Rutter.

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation – Kathleen A. Boyle, Jonathan Van Wickle, R. Blake Hill, Adriano Marchese, Balaraman Kalyanaraman and Michael B. Dwinell.

Mitochondrial Complex I Activity Is Required for Maximal Autophagy – Hala Elnakat Thomas, Yu Zhang, Jonathan A. Stefely, Sonia R. Veiga, George Thomas, Sara C. Kozma, Carol A. Mercer.

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity – Caroline Giessner, Virginie Millet, Konrad J Mostert, Thomas Gensollen, Thien-Phong Vu Manh, Marc Garibal, Binta Dieme, Noudjoud Attaf-Bouabdallah, Lionel Chasson, Nicolas Brouilly, Caroline Laprie, Tom Lesluyes, Jean Yves Blay, Laetitia Shintu, Jean Charles Martin, Erick Strauss, Franck Galland, Philippe Naquet.

Starvation / nutrient sensing

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms – Arvin B. Tam, Lindsay S. Roberts, Vivek Chandra, Io Guane Rivera, Daniel K. Nomura, Douglass J. Forbes, Maho Niwa.

Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis – Paulo A. Gameiro, Kevin Struhl.

A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold – Rosalie E. Lawrence, Kelvin F. Cho, Ronja Rappold, Anna Thrun, Marie Tofaute.

Feedback regulation of TORC1 by its downstream effectors Npr1 and Par33 – Natalia V. Varlakhanova, Bryan A. Tornabene, and Marijn G. J. Ford.

Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism – Keren E. Shapira, Marcelo Ehrlichand, Yoav I. Henis.

Cancer immunometabolism

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 – Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung-Oe Lim, Chia-Wei Li, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Jennifer L. Hsu, Hung-Ling Wang, Chu-Wei Kuo, Wei-Chao Chang, Sirwan Hadad, Colin A. Purdie, Aaron M. McCoy, Shirong Cai, Yizheng Tu, Jennifer K. Litton, Elizabeth A. Mittendorf, Stacy L. Moulder, William F. Symmans, Alastair M. Thompson, Helen Piwnica-Worms, Chung-Hsuan Chen, Kay-Hooi Khoo, Mien-Chie Hung.

Hexokinase 2 is dispensable for T cell-dependent immunity – Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay and Navdeep S. Chandel.

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death – Tsadik Habtetsion, Zhi-Chun Ding, Wenhu Pi, Tao Li, Chunwan Lu, Tingting Chen, Caixia Xi, Helena Spartz, Kebin Liu, Zhonglin Hao, Nahid Mivechi, Yuqing Huo, Bruce R. Blazar, David H. Munn, Gang Zhou.

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression – Jingjing Cong, Xianwei Wang, Xiaohu Zheng, Dong Wang, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei.


Myc and ChREBP Transcription Factors Cooperatively Regulate Normal and Neoplastic Hepatocyte Proliferation in Mice – Huabo Wang, James M. Dolezal, Sucheta Kulkarni, Jie Lu, Jordan Mandel, Laura E. Jackson, Frances Alencastro, Andrew W. Duncan and Edward V. Prochownik.

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment – Matheus Dyczynski, Mattias Vesterlund, Ann-Charlotte Björklund, Vasilios Zachariadis, Jerry Janssen, Hector Gallart-Ayala, Evangelia Daskalaki, Craig E. Wheelock, Janne Lehtiö, Dan Grandér, Katja Pokrovskaja Tamm, Roland Nilsson.

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib – Lynn Quek, Muriel D. David, […] Paresh Vyas.

Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development – Jiaqing Hao, Yuwen Zhang, Xiaofang Yan, Fei Yan, Yanwen Sun, Jun Zeng, Sabine Waigel, Yanhui Yin, Mostafa M. Fraig, Nejat K. Egilmez, Jill Suttles, Maiying Kong, Shujun Liu, Margot P. Cleary, Edward Sauter, Bing Li.


Biological Role and Therapeutic Potential of IDH Mutations in Cancer – Matthew S. Waitkus, Bill H. Diplas, Hai Yan.

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci.

Translating In Vitro T Cell Metabolic Findings to In VivoTumor Models of Nutrient Competition – Christopher Ecker and James L. Riley.

The different axes of the mammalian mitochondrial unfolded protein response – Christian Münch.

RAS signalling in energy metabolism and rare human diseases – Dard, N. Bellance, D. Lacombe, R. Rossignol.

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies – Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden.

Regulation of chromatin and gene expression by metabolic enzymes and metabolites – Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger & Zhimin Lu.

Perspectives on IDH Mutation in Diffuse Gliomas – Yu-Ting Su, Funita P. Phan, Jing Wu.

Interplay between YAP/TAZ and Metabolism – Ja Hyun Koo, Kun-Liang Guan.

Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase – Tereza Golias, Martin Kery, Silvia Radenkovic, Ioanna Papandreou.

Metabolic Plasticity of Tumor Cell Mitochondria – Giuseppe Cannino, Francesco Ciscato, Ionica Masgras, Carlos Sánchez-Martín, and Andrea Rasola.

Understanding lymphocyte metabolism for use in cancer immunotherapy – Sarah MacPherson, Marisa Kilgour, Julian J. Lum.

The big picture: exploring the metabolic cross-talk in cancer – Almut Schulze, Mariia Yuneva.


Lysosomal catch-and-release controls mTORC1 – Aaron M. Hosios & Brendan D. Manning.

ERADicate Tumor Progression with Metformin – Lena-Sophie Dreher, Thorsten Hoppe.

An OXPHOS Inhibitor Has Antitumor Activity in Multiple Tumor Models

Second-Site IDH2 Mutations Confer Resistance to Enasidenib In Trans

Starving cancer cells to death: Cisplatin-resistant cancer cells are particularly susceptible to starvation-induced death.

MetaboList – July 2018

Amino acid metabolism

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
Anneleen Daemen, Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, David Peterson, Bianca M. Liederer, Cecile de la Cruz, Dewakar Sangaraju, Allan Jaochico, Xiaofeng Zhao, Wendy Sandoval, Thomas Hunsaker, Ron Firestein, Sheerin Latham, Deepak Sampath, Marie Evangelista, Georgia Hatzivassiliou

Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A. Lewis, Richard L. Possemato & Kıvanç Birsoy

Metabolic vulnerability of cisplatin‐resistant cancers
Florine Obrist, Judith Michels, Sylvere Durand, Alexis Chery, Jonathan Pol, Sarah Levesque, Adrien Joseph, Valentina Astesana, Federico Pietrocola, Gen Sheng Wu, Maria Castedo and Guido Kroemer

Glucose metabolism

Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging
Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong, Jing Gao, and Hongda Wang

MicroRNA-31-5p enhances the Warburg effect via targeting FIH
Biying Zhu, Xiuye Cao, Wenqiang Zhang, Guoping Pan, Qing Yi, Wenbin Zhong, and Daoguang Yan

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells
Audrey Berthe, Marie Zaffino, Claire Muller, François Foulquier, Marine Houdou, Céline Schulz, Frédéric Bost, Elia De Fay, Sabine Mazerbourg,  Stéphane Flament

Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C. Kolwicz Jr, Daniel Raftery & Rong Tian


Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis


Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma
Raj K. Gopal, Sarah E. Calvo, Angela R. Shih, Frances L. Chaves, Declan McGuone, Eran Mick, Kerry A. Pierce, Yang Li, Andrea Garofalo, Eliezer M. Van Allen, Clary B. Clish, Esther Oliva, and Vamsi K. Mootha

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma
Ying Pang, Yanxin Lu, Veronika Caisova, Yang Liu, Petra Bullova, Thanh-Truc Huynh, Yiqiang Zhou, Di Yu, Zdenek Frysak, Igor Hartmann, David Taïeb, Karel Pacak and Chunzhang Yang

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer
Harvey R. Fernandez, Shreyas M. Gadre, Mingjun Tan, Garrett T. Graham, Rami Mosaoa, Martin S. Ongkeko, Kyu Ah Kim, Rebecca B. Riggins, Erika Parasido, Iacopo Petrini, Simone Pacini, Amrita Cheema, Rency Varghese, Habtom W Ressom, Yuwen Zhang, Christopher Albanese, Aykut Üren, Mikell Paige, Giuseppe Giaccone & Maria Laura Avantaggiati

An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Jennifer R. Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi et al.  Joseph R. Marszalek

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Yonathan Lissanu Deribe, Yuting Sun, Christopher Terranova, Fatima Khan, Juan Martinez-Ledesma et al.[…] P. Andrew Futreal

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Yichong Zhang, Ji-Hoon Lee, Tanya T Paull, Sarah Gehrke, Angelo D’Alessandro, Qianhui Dou, Vadim N Gladyshev, Elizabeth A Schroeder, Samantha K Steyl, Brooke E Christian, Gerald S Shadel

LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells
Lara Gibellini, Lara Gibellini, Lorena Losi, Lorena Losi, Sara De Biasi, Sara De Biasi, Milena Nasi, Milena Nasi, Domenico Lo Tartaro, Domenico Lo Tartaro, Simone Pecorini, Simone Pecorini, Simone Patergnani, Simone Patergnani, Paolo Pinton, Paolo Pinton, Anna De Gaetano, Anna De Gaetano, Gianluca Carnevale, Gianluca Carnevale, Alessandra Pisciotta, Alessandra Pisciotta, Francesco Mariani, Luca Roncucci, Luca Roncucci, Anna Iannone, Anna Iannone, Andrea Cossarizza, Andrea Cossarizza, Marcello Pinti, and Marcello Pinti

Starvation / diet

Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
Alicia M. Darnell, Arvind R. Subramaniam, Erin K. O’Shea

Control of the polyamine biosynthesis pathway by G2-quadruplexes
Helen Louise Lightfoot, Timo Hagen, Antoine Cléry, Frédéric Hai-Trieu Allain, Jonathan Hall

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins, Chantal Pauli, Xing Du, Diana G. Wang, Xiang Li, David Wu, Solomon C. Amadiume, Marcus D. Goncalves, Cindy Hodakoski, Mark R. Lundquist, Rohan Bareja, Yan Ma, Emily M. Harris, Andrea Sboner, Himisha Beltran, Mark A. Rubin, Siddhartha Mukherjee & Lewis C. Cantley


Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins
Kalpana Deepa Priya Dorayappan, Ross Wanner, John J. Wallbillich, Uksha Saini, Roman Zingarelli, Adrian A. Suarez, David E. Cohn & Karuppaiyah Selvendiran

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways
Xiaofan Guo, Wei Qiu, Qinglin Liu, Mingyu Qian, Shaobo Wang, Zongpu Zhang, Xiao Gao, Zihang Chen, Hao Xue & Gang Li

Intermittent hypoxia induces a metastatic phenotype in breast cancer
Anna Chen, Jaclyn Sceneay, Nathan Gödde, Tanja Kinwel, Sunyoung Ham, Erik W Thompson, Patrick O Humbert & Andreas Möller

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia
Astrid A. Glück, Eleonora Orlando, Dominic Leiser, Michaela Poliaková, Lluís Nisa, Aurélie Quintin, Jacopo Gavini, Deborah M. Stroka, Sabina Berezowska, Lukas Bubendorf, Andree Blaukat, Daniel M. Aebersold, Michaela Medová & Yitzhak Zimmer


LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis
M C Poffenberger, A Metcalfe-Roach, E Aguilar, J Chen, B E Hsu, A H Wong, R M Johnson, B Flynn, B Samborska, E H Ma, S P Gravel, L Tonelli, L Devorkin, P Kim, A Hall, S Izreig, E Loginicheva, N Beauchemin, P M Siegel, M N Artyomov, J J Lum, G Zogopoulos, J Blagih, R G Jones

AMP kinase promotes glioblastoma bioenergetics and tumour growth
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M. Chow, Zaza Khuchua, Matthew Kofron, Matthew T. Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov & Biplab Dasgupta

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells


mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma
Luca Drusian, Elisa Agnese Nigro, Valeria Mannella, Roberto Pagliarini, Monika Pema, Ana S.H. Costa, Fabio Benigni, Alessandro Larcher, Marco Chiaravalli, Edoardo Gaude, Francesco Montorsi, Umberto Capitanio, Giovanna Musco, Christian Frezza, Alessandra Boletta

TORC1 inhibition enhances immune function and reduces infections in the elderly
Joan B. Mannick, Melody Morris, Hans-Ulrich P. Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins1, Tea Shavlakadze1, Weihua Zhou1, Dean Quinn, David J. Glass1 and Lloyd B. Klickstein

Metabolism and chromatin

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu, Di Hu, […] Yujiang Geno Shi

Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors
Ashley R. Maiuri, Hongde Li, Barry D. Stein, Jason M. Tennessen and Heather M. O’Hagan

α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
Sandra Atlante, Alessia Visintin, Elisabetta Marini, Matteo Savoia, Chiara Dianzani Marta Giorgis, Duran Sürün,Federica Maione, Frank Schnütgen, Antonella Farsetti, Andreas M. Zeiher, Massimo Bertinaria, Enrico Giraudo, Francesco Spallotta, Chiara Cencioni & Carlo Gaetano

Metabolic cell-cell cross-talk

Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Dhruv Kumar, Jacob New, Vikalp Vishwakarma, Radhika Joshi, Jonathan Enders, Fangchen Lin, Sumana Dasari, Wade R. Gutierrez, George Leef, Sivapriya Ponnurangam, Hemantkumar Chavan, Lydia Ganaden, Mackenzie M. Thornton, Hongying Dai, Ossama Tawfik, Jeffrey Straub, Yelizaveta Shnayder, Kiran Kakarala, Terance Ted Tsue, Douglas A. Girod, Bennett Van Houten, Shrikant Anant, Partha Krishnamurthy and Sufi Mary Thomas

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou

In vivo imaging

Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients
Vesselin Z. Miloushev, Kristin L. Granlund, Rostislav Boltyanskiy, Serge K. Lyashchenko, Lisa M. DeAngelis, Ingo K. Mellinghoff, Cameron W. Brennan, Vivian Tabar, T. Jonathan Yang, Andrei I. Holodny, Ramon E. Sosa, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb and Kayvan R. Keshari

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect
Bradley T. Scroggins, Masayuki Matsuo, Ayla O. White, Keita Saito, Jeeva P. Munasinghe, Carole Sourbier, Kazutoshi Yamamoto, Vivian Diaz, Yoichi Takakusagi, Kazuhiro Ichikawa, James B. Mitchell, Murali C. Krishna and Deborah E. Citrin


Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer
Yongliang Wang, Ali R. Nasiri, William E. Damsky, Curtis J. Perry, Xian-Man Zhang, Aviva Rabin-Court, Michael N. Pollak, Gerald I. Shulman, Rachel J. Perry

Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress
Krissie Lenting, Mohammed Khurshed, Tom H. Peeters, Corina N. A. M. van den Heuvel, Sanne A. M. van Lith, Tessa de Bitter, Wiljan Hendriks, Paul N. Span, Remco J. Molenaar, Dennis Botman, Kiek Verrijp, Arend Heerschap, Mark ter Laan, Benno Kusters, Anne van Ewijk, Martijn A. Huynen, Cornelis J. F. van Noorden, and William P. J. Leenders

Systems analysis of intracellular pH vulnerabilities for cancer therapy
Erez Persi, Miquel Duran-Frigola, Mehdi Damaghi, William R. Roush, Patrick Aloy, John L. Cleveland, Robert J. Gillies & Eytan Ruppin

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Ajit S. Divakaruni, Wei Yuan Hsieh, […], Steven J. Bensinger, Anne N. Murphy

FABP4 as a key determinant of metastatic potential of ovarian cancer
Kshipra M. Gharpure, Sunila Pradeep, […] Anil K. Sood


Metabolic Signaling to the Nucleus in Cancer
Sydney L. Campbell, Kathryn E. Wellen

Metabolic regulation of chromatin modifications and gene expression
Juan Manuel Schvartzman, Craig B. Thompson, Lydia W.S. Finley

The nutrient environment affects therapy

The multifaceted contributions of mitochondria to cellular metabolism
Jessica B. Spinelli & Marcia C. Haigis

Unraveling the Role of Angiogenesis in Cancer Ecosystems
Iratxe Zuazo-Gaztelu, and Oriol Casanovas

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Verónica Eisner, Martin Picard & György Hajnóczky

NRF2 and the Hallmarks of Cancer
Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang

Modulation of the secretory pathway by amino-acid starvation
Wessel van Leeuwen, Felix van der Krift, Catherine Rabouille

Glutathione metabolism in cancer progression and treatment resistance
Ankita Bansal, M. Celeste Simon

Comments / other

Histidine metabolism boosts cancer therapy
Christian Frezza

Pro-tumorigenic AMPK in glioblastoma
Nektaria Maria Leli & Constantinos Koumenis

Periodic fasting starves cisplatin‐resistant cancers to death
Novella Guidi and Valter D Longo

Grasping for aspartate in tumour metabolism
Accalia Fu & Nika N. Danial

A Glycolysis Outsider Steps into the Cancer Spotlight
Marcus D. Goncalves, Lewis C. Cantley

Spoon-Feeding Ribosomes to Autophagy
Hitoshi Nakatogawa

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming
Lorena Esteban-Martínez & Patricia Boya

How to eliminate MYCN-positive hepatic cancer stem cells to prevent the recurrence?
Go J. Yoshida –
Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming
Xian-Yang Qin, Naoshi Dohmae, and Soichi Kojima –

Q & A – Karen Vousden

Finding clues in the p53 maze: an interview with Karen Vousden

Erika Pearce: Fitting metabolism and immunity together, to a T

Jerry Chipuk: A powerhouse for mitochondrial biology

MetaboList – June 2018

Glucose metabolism

Four Key Steps Control Glycolytic Flux in Mammalian Cells
Lukas Bahati Tanner, Alexander G. Goglia, Monica H. Wei, Talen Sehgal, Lance R. Parsons, Junyoung O. Park, Eileen White, Jared E. Toettcher, Joshua D. Rabinowitz

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis
Pengcheng Bu, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, Lihua Wang, Rui Xi, Inna Astapova, Yan Han, Jiahe Li, Bradley B. Barth, Min Lu, Ziyang Gao, Robert Mines, Liwen Zhang, Mark Herman, David Hsu, Guo-Fang Zhang, Xiling Shen

Mathematical Modeling of the Function of Warburg Effect in Tumor Microenvironment
Milad Shamsi, Mohsen Saghafian, Morteza Dejam & Amir Sanati-Nezhad

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai and Harvey R. Herschman

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino and Letizia Lanzetti

Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis
Qian Sun, Shuzhan Li, Yanan Wang, Haiyong Peng, Xiying Zhang, Yu Zheng, Chunjia Li, Li Li, Rongrong Chen, Xinxin Chen, Wenjing Bai, Xiangli Jiang, Liang Liu, Feng Wei, Boshi Wang, Yu Zhang, Hui Li, Xiubao Ren & Hongbing Zhang

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics
Shao Thing Teoh, Martin Ogrodzinski, Christina Ross, Kent Hunter, and Sophia Lunt

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks

Yota Yasumizu, Hiroshi Hongo, Takeo Kosaka, Shuji Mikami, Koshiro Nishimoto, Eiji Kikuchi, and Mototsugu Oya

Amino acid metabolism and urea cycle

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells
Chih‐Sheng Yang, Eleni Stampouloglou, Nathan M Kingston, Liye Zhang, Stefano Monti and Xaralabos Varelas

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity
Joshua D. Ochocki, Sanika Khare, Markus Hess, Daniel Ackerman, Bo Qiu, Jennie I. Daisak, Andrew J. Worth, Nan Lin, Pearl Lee, Hong Xie, Bo Li, Bradley Wubbenhorst, Tobi G. Maguire, Katherine L. Nathanson, James C. Alwine, Ian A. Blair, Itzhak Nissim, Brian Keith, M. Celeste Simon

Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer
Yaping Shao, Guozhu Ye, Shancheng Ren, Hai‐Long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun, Guowang Xu

Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells
Stephanie Lucas, Guohua Chen, Siddhesh Aras, Jian Wang

Lipid metabolism

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer
Anju Singh, Christian Ruiz, Kavita Bhalla, John A. Haley, Qing Kay Li, George Acquaah-Mensah, Emily Montal, Kuladeep R. Sudini, Ferdinandos Skoulidis, Ignacio I. Wistuba, Vassiliki Papadimitrakopoulou, John V. Heymach, Laszlo G. Boros, Edward Gabrielson, Julian Carretero, Kwok-kin Wong, John D. Haley, Shyam Biswal, and Geoffrey D. Girnun

Preparation of Lipid-Stripped Serum for the Study of Lipid Metabolism in Cell Culture
Aaron M. Hosios, Zhaoqi Li, Evan C. Lien, Matthew G. Vander Heiden

PPARγ is dispensable for clear cell renal cell carcinoma progression
Danielle J. Sanchez, David J. Steger, Nicolas Skuli, Ankita Bansal, M. Celeste Simon

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
Hideki Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells
Katharina Leithner, Alexander Triebl, Martin Trötzmüller, Barbara Hinteregger, Petra Leko, Beatrix I. Wieser, Gabriele Grasmann, Alexandra L. Bertsch, Thomas Züllig, Elvira Stacher, Alessandro Valli, Ruth Prassl, Andrea Olschewski, Adrian L. Harris, Harald C. Köfeler, Horst Olschewski, and Andelko Hrzenjak

Structural basis for regulation of human acetyl-CoA carboxylase
Moritz Hunkeler, Anna Hagmann, Edward Stuttfeld, Mohamed Chami, Yakir Guri, Henning Stahlberg & Timm Maier

Nucleotides and NAD

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides
Olivier Sallin, Luc Reymond, Corentin Gondrand, Fabio Raith, Birgit Koch, Kai Johnsson

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
D. Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Terttu Suormala, Seraina Lutz, Rod Chalk, Oktawia Borkowska, Matthias R. Baumgartner & Wyatt W. Yue


Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism
Julie Lavie, Harmony De Belvalet, Sessinou Sonon, Ana Madalina Ion, Elodie Dumon, Su Melser, Didier Lacombe, Jean-William Dupuy, Claude Lalou, Giovanni Bénard

MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis
Eunjin Koh, Young Kyung Kim, Daye Shin and Kyung-Sup Kim

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
Julian Hlouschek, Christine Hansel, Verena Jendrossek, and Johann Matschke


PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells
Seong M. Kim, Tricia T. Nguyen, Archna Ravi, Peter Kubiniok, Brendan T. Finicle, Vaishali Jayashankar, Leonel Malacrida, Jue Hou, Jane Robertson, Dong Gao, Jonathan Chernoff, Michelle A. Digman, Eric O. Potma, Bruce J. Tromberg, Pierre Thibault and Aimee L. Edinger

Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation
Nan Zhang, Xin Yang, Fengjie Yuan, Luyao Zhang, Yanan Wang, Lina Wang, Zebin Mao, Jianyuan Luo, Hongquan Zhang, Wei-Guo Zhu, Ying Zhao

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations
Raphaela Fritsche-Guenther, Christin Zasada, Guido Mastrobuoni, Nadine Royla, Roman Rainer, Florian Roßner, Matthias Pietzke, Edda Klipp, Christine Sers & Stefan Kempa

Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress
Florian A. Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann S. Gallot, Aurélie Docquier, Allan F. Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, Béatrice Chabi, Marc Francaux, François Casas, Damien Freyssenet, Jennifer Rieusset, Sophie Giorgetti-Peraldi, Gilles Carnac, Vincent Ollendorff, François B. Favier

Nutrient sensing

The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect
Mónica Rosas Lemus, Elodie Roussarie, Noureddine Hammad, Alexis Mougeolle, Stéphane Ransac, Razanne Issa, Jean-Pierre Mazat, Salvador Uribe-Carvajal, Michel Rigoulet and Anne Devin

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway
Minji Lee, Jong Hyun Kim, Ina Yoon, Chulho Lee, Mohammad Fallahi Sichani, Jong Soon Kang, Jeonghyun Kang, Min Guo, Kang Young Lee, Gyoonhee Han, Sunghoon Kim, and Jung Min Han

High Glucose Reduces Megalin-Mediated Albumin Endocytosis in Renal Proximal Tubule Cells through Protein Kinase B O-GlcNAcylation
Diogo de Barros Peruchetti, Rodrigo Pacheco Silva-Aguiar, Gabriela Marques Siqueira, Wagner Barbosa Dias and Celso Caruso-Neves

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
Meng Yuan, Iain W. McNae, Yiyuan Chen, Elizabeth A. Blackburn, Martin A. Wear, Paul A.M. Michels, Linda A. Fothergill-Gilmore, Ted Hupp and Malcolm D. Walkinshaw


Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth
Elisabetta Zulato, Francesco Ciccarese, Giorgia Nardo, Marica Pinazza, Valentina Agnusdei, Micol Silic-Benussi, Vincenzo Ciminale, and Stefano Indraccolo

Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis
Eloy Moreno Roig, Ala Yaromina, Ruud Houben, Arjan J Groot, Ludwig Dubois, and Marc Vooijs

Codon-specific translation reprogramming promotes resistance to targeted therapy
Francesca Rapino, Sylvain Delaunay, […]Pierre Close


Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
Courtney D. DiNardo, Eytan M. Stein, Stéphane de Botton, Gail J. Roboz, Jessica K. Altman, Alice S. Mims, Ronan Swords, Robert H. Collins, Gabriel N. Mannis, Daniel A. Pollyea, Will Donnellan, Amir T. Fathi, Arnaud Pigneux, Harry P. Erba, Gabrielle T. Prince, Anthony S. Stein, Geoffrey L. Uy, James M. Foran, Elie Traer, Robert K. Stuart, Martha L. Arellano, James L. Slack, Mikkael A. Sekeres, Christophe Willekens, Sung Choe, Hongfang Wang, Vickie Zhang, Katharine E. Yen, Stephanie M. Kapsalis, Hua Yang, David Dai, Bin Fan, Meredith Goldwasser, Hua Liu, Sam Agresta, Bin Wu, Eyal C. Attar, Martin S. Tallman, Richard M. Stone, and Hagop M. Kantarjian

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
Andrew M. Intlekofer, Alan H. Shih, Bo Wang, Abbas Nazir, Ariën S. Rustenburg, Steven K. Albanese, Minal Patel, Christopher Famulare, Fabian M. Correa, Naofumi Takemoto, Vidushi Durani, Hui Liu, Justin Taylor, Noushin Farnoud, Elli Papaemmanuil, Justin R. Cross, Martin S. Tallman, Maria E. Arcila, Mikhail Roshal, Gregory A. Petsko, Bin Wu, Sung Choe, Zenon D. Konteatis, Scott A. Biller, John D. Chodera, Craig B. Thompson, Ross L. Levine & Eytan M. Stein

IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
Mohammed Khurshed, Niels Aarnoudse, Renske Hulsbos, Vashendriya V. V. Hira, Hanneke W. M. van Laarhoven, Johanna W. Wilmink, Remco J.Molenaar, and Cornelis J. F. van Noorden

Metformin / phenformin

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR
Sónia R. Veiga, Xuemei Ge, Carol A. Mercer, María I. Hernández-Álvarez, Hala Elnakat Thomas, Javier Hernandez-Losa, Santiago Ramón y Cajal, Antonio Zorzano, George Thomas and Sara C. Kozma

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
Elisabet Cuyàs, Sara Verdura, Laura Llorach‐Pares, Salvador Fernández‐Arroyo, Fedra Luciano‐Mateo, Noemí Cabré, Jan Stursa, Lukas Werner, Begoña Martin‐Castillo, Benoit Viollet, Jiri Neuzil, Jorge Joven, Alfons Nonell‐Canals, Melchor Sanchez‐Martinez, Javier A. Menendez

Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo
Shilpa Thakur, Brianna Daley, Kelli Gaskins, Vasyl V. Vasko, Myriem Boufraqech, Dhaval Patel, Carole Sourbier, Jeff Reece, Sheue-Yann Cheng, Electron Kebebew, Sunita Agarwal and Joanna Klubo-Gwiezdzinska


Altered exocrine function can drive adipose wasting in early pancreatic cancer
Laura V. Danai, Ana Babic, Michael H. Rosenthal, Emily A. Dennstedt, Alexander Muir, Evan C. Lien, Jared R. Mayers, Karen Tai, Allison N. Lau, Paul Jones-Sali, Carla M. Prado, Gloria M. Petersen, Naoki Takahashi, Motokazu Sugimoto, Jen Jen Yeh, Nicole Lopez, Nabeel Bardeesy, Carlos Fernandez-del Castillo, Andrew S. Liss, Albert C. Koong, Justin Bui, Chen Yuan, Marisa W. Welch, Lauren K. Brais, Matthew H. Kulke, Courtney Dennis, Clary B. Clish, Brian M. Wolpin & Matthew G. Vander Heiden

Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nrf2 Activation.
Li Y, Chao X, Yang L, Lu Q, Li T, Ding WX, Ni HM.

Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation
Catharina Bartmann, Sudha R. Janaki Raman, Jessica Flöter, Almut Schulze, Katrin Bahlke, Jana Willingstorfer, Maria Strunz, Achim Wöckel, Rainer J. Klement, Michaela Kapp, Cholpon S. Djuzenova, Christoph Otto and Ulrike Kämmerer

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
Nobuaki Takahashi, Hsing-Yu Chen, Isaac S. Harris, Daniel G. Stover, Laura M. Selfors, Roderick T. Bronson, Thomas Deraedt, Karen Cichowski, Alana L. Welm, Yasuo Mori, Gordon B. Mills, Joan S. Brugge

TAp73 contributes to the oxidative stress response by regulating protein synthesis
Alberto Marini, Barak Rotblat, Thomas Sbarrato, Maria Victoria Niklison-Chirou, John R. P. Knight, Kate Dudek, Carolyn Jones, Martin Bushell, Richard A. Knight, Ivano Amelio, Anne E. Willis, and Gerry Melino

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6
Brendan T. Finicle, Manuel U. Ramirez, Gang Liu, Elizabeth M. Selwan, Alison N. McCracken, Jingwen Yu, Yoosun Joo, Jannett Nguyen, Kevin Ou, Saurabh Ghosh Roy, Victor D. Mendoza, Dania Virginia Corrales and Aimee L. Edinger

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation
Mohsen Hosseini, Léa Dousset, Walid Mahfouf, Martin Serrano-Sanchez, Isabelle Redonnet-Vernhet, Samir Mesli, Zeinab Kasraian, Emilie Obre, Marc Bonneu, Stephane Claverol, Marija Vlaski, Zoran Ivanovic, Walid Rachidi, Thierry Douki, Alain Taieb, Anne-Karine Bouzier-Sore, Rodrigue Rossignol, Hamid Reza Rezvani

GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma
Weiruo Zhang, Gina Bouchard, Alice Yu, Majid Shafiq, Mehran Jamali, Joseph B. Shrager, Kelsey Ayers, Shaimaa Bakr, Andrew J. Gentles, Maximilian Diehn, Andrew Quon, Robert B. West, Viswam Nair, Matt van de Rijn, Sandy Napel and Sylvia K. Plevritis


Recent advances in cancer metabolism: a technological perspective
Yun Pyo Kang, Nathan P. Ward & Gina M. DeNicola

The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate
Peng Wei, Katja K. Dove, Claire Bensard, John C. Schell, Jared Rutter

Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Patricia Boya, Patrice Codogno, Natalia Rodriguez-Muela

Cancer Stem Cell Metabolism and Potential Therapeutic Targets
Vusala Snyder, Tamika Reed-Newman, Levi Arnold, Sufi Thomas, and Shrikant Anant

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication
Ernestina M. De Francesco, Federica Sotgia and Michael P. Lisanti

Hypoxia-Inducible Factor 2-Dependent Pathways Driving Von Hippel–Lindau-Deficient Renal Cancer
Florinda Melendez Rodriguez, Olga Roche, Ricardo Sanchez-Prieto, and Julián Aragones Lopez

Hypoxic Signalling in Tumour Stroma
Anu Laitala, and Janine Erler

Nutrient sensing, growth and senescence
Bernadette Carroll and Viktor I. Korolchuk

The role of DNA‐PK in aging and energy metabolism
Jay H. Chung

Regulation of chromatin and gene expression by metabolic enzymes and metabolites
Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger & Zhimin Lu

Metabolic Regulation of Transcription and Chromatin
Ronald C. Conaway
* Willis IM, Moir RD. 2018. Signaling to and from the RNA polymerase III transcription and processing machinery.
* Suganuma T, Workman JL. 2018. Chromatin and metabolism.


Obesity Protects Cancer from Drugs Targeting Blood Vessels
Yihai Cao

A lysosomal proton pump turns on when glucose runs out
Karlett J. Parra and Summer R. Hayek

OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!
Christos Chinopoulos

ROS Promotes Cancer Cell Survival through Calcium Signaling
Colleen R. Reczek, Navdeep S. Chandel

Basis of dATP inhibition of RNRs
Brandon L. Greene, Daniel G. Nocera and JoAnne Stubbe

Macropinocytosis Fuels Prostate Cancer
Cosimo Commisso and Jayanta Debnath

Companies Scaling Back IDO1 Inhibitor Trials

Lung Cancer – Targeting Glutaminase May Overcome Resistance to mTOR Inhibition

MetaboList – May 2018

Amino  acid metabolism

The  GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
Milica  Momcilovic, Sean T. Bailey, Jason T. Lee, Michael C. Fishbein, Daniel Braas, James Go, Thomas G. Graeber, Francesco Parlati, Susan Demo, Rui Li, Tonya C. Walser, Michael Gricowski, Robert Shuman, Julio Ibarra, Deborah Fridman, Michael E. Phelps, Karam Badran,  Maie St. John, Nicholas M. Bernthal, Noah Federman, Jane Yanagawa, Steven M. Dubinett, Saman Sadeghi, Heather R. Christofk, David B. Shackelford

xCT  (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression
Xiangming  Ji, Jun Qian, S. M. Jamshedur Rahman, Peter J. Siska, Yong Zou, Bradford K. Harris, Megan D. Hoeksema, Irina A. Trenary, Chen Heidi, Rosana Eisenberg, Jeffrey C. Rathmell, Jamey D. Young & Pierre P. Massion

Methionine  metabolism influences genomic architecture and gene expression through H3K4me3 peak width
Ziwei  Dai, Samantha J. Mentch, Xia Gao, Sailendra N. Nichenametla & Jason W. Locasale

ATF4  Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming
Xi  Yang, Rui Xia, Cuihua Yue, Wensi Zhai, Wenwen Du, Qianting Yang, Huiling Cao, Xiaojuan Chen, Danielle Obando, Yibei Zhu, Xinchun Chen, Jane-Jane Chen, Jon Piganelli, Peter Wipf, Yu Jiang, Guozhi Xiao, Changping Wu, Jingting Jiang, Binfeng Lu

Elevated  mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide
Huiyuan  Zhang, Qinyi Wang, Junzhong Gu, Le Yin, Shenghui Liang, Lida Wu, Hao Xu, Chao Zhao & Yuchun Gu

Restoration  of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan metabolic switch and attenuates cancer progression
Hua-Ling  Chen, Chao-Yun Yuan, Huei-Hsuan Cheng, Tzu-Ching Chang, Shau-Ku Huang, Cheng-Chin Kuo and Kenneth K Wu

Serine  catabolism is essential to maintain mitochondrial respiration in  mammalian cells
Stephanie  Lucas, Guohua Chen, Siddhesh Aras and Jian Wang

Glucose  metabolism

Regulation  of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2)
Lin  Jiao, Hai-Liang Zhang, Dan-Dan Li, Ke-Li Yang, Jun Tang, Xuan Li, Jiao Ji, Yan Yu, Rui-Yan Wu, Senthilkumar Ravichandran, Jian-Jun Liu, Gong-Kan Feng, Min-Shan Chen, Yi-Xin Zeng, Rong Deng & Xiao-Feng Zhu

Shamir  Cassim, Valérie-Ann Raymond, Benoit Lacoste, Pascal Lapierre,  and  Marc Bilodeau

EP300-Mediated Lysine 2-Hydroxyisobutyrylation  Regulates Glycolysis
He  Huang, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, Jason W. Locasale, Robert G. Roeder, Yingming Zhao,  Xiaoling Li

Targeting  PFKFB3 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitor
Yu  Zhu, Luo Lu, Chun Qiao, Yi Shan, Huapeng Li, Sixuan Qian, Ming Hong, Huihui Zhao, Jianyong Li , Zhongfa Yang & Yaoyu Chen

A  new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo
Luigi  Mele, Francesca Paino, Federica Papaccio, Tarik Regad, David Boocock, Paola Stiuso, Angela Lombardi, Davide Liccardo, Gabriella Aquino, Antonio Barbieri, Claudio Arra, Clare Coveney, Marcella La Noce, Gianpaolo Papaccio, Michele Caraglia, Virginia Tirino &  Vincenzo Desiderio

Transketolase  Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway
Chien-Wei  Tseng, Wen-Hung Kuo, Shih-Hsuan Chan, Hong-Lin Chan, King-Jen Chang and Lu-Hai Wang

Lipid  metabolism / citrate

Cancer  Lipid Metabolism Confers Antiangiogenic Drug Resistance
Hideki  Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao

Extracellular  Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo
Maria  E. Mycielska, Katja Dettmer, Petra Rümmele, Katharina Schmidt, Cornelia Prehn, Vladimir M. Milenkovic, Wolfgang Jagla, Gregor M. Madej, Margareta Lantow, Moritz Schladt, Alexander Cecil, Gudrun E. Koehl, Elke Eggenhofer, Christian J. Wachsmuth, Vadivel Ganapathy,  Hans J. Schlitt, Karl Kunzelmann, Christine Ziegler, Christian H. Wetzel, Andreas Gaumann, Sven A. Lang, Jerzy Adamski, Peter J. Oefner and Edward K. Geissler

Nucleotides and NAD

Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis
Keun Woo Ryu, Tulip Nandu, Jiyeon Kim, Sridevi Challa, Ralph J. DeBerardinis, W. Lee Kraus

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence
Giulia Santinon, Irene Brian, Arianna Pocaterra, Patrizia Romani, Elisa Franzolin, Chiara Rampazzo, Silvio Bicciato and Sirio Dupont

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.
Philippe C, Pinson B, Dompierre J, Pantesco V, Viollet B, Daignan-Fornier B, Moenner M.


Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II
Guoyu Yu, Chien-Jui Cheng, Song-Chang Lin, Yu-Chen Lee, Daniel E. Frigo, Li-Yuan Yu-Lee, Gary E. Gallick, Mark A. Titus, Leta K. Nutt and Sue-Hwa Lin

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling
Joyce V. Lee, Corbett T. Berry, Karla Kim, Payel Sen, Taehyong Kim, Alessandro Carrer, Sophie Trefely, Steven Zhao, Sully Fernandez, Lauren E. Barney, Alyssa D. Schwartz, Shelly R. Peyton, Nathaniel W. Snyder, Shelley L. Berger,  Bruce D. Freedman and Kathryn E. Wellen

Starvation / nutrient sensing

NUFIP1 is a ribosome receptor for starvation-induced ribophagy
Gregory A. Wyant, Monther Abu-Remaileh, Evgeni M. Frenkel, Nouf N. Laqtom, Vimisha Dharamdasani, Caroline A. Lewis, Sze Ham Chan, Ivonne Heinze, Alessandro Ori, David M. Sabatini

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
Jie Chen, Yuhui Ou, Yanyan Yang, Wen Li, Ye Xu, Yuntao Xie & Ying Liu

The Gcn2–eIF2α pathway connects iron and amino acid homeostasis in Saccharomyces cerevisiae
Marcos Caballero-Molada, María D. Planes, Helena Benlloch, Sergio Atares,Miguel A. Naranjo and Ramón Serrano

Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation
Richard S Marshall, Richard D Vierstra

Hierarchical mechanism of amino acid sensing by the T-box riboswitch
Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz & Nils G. Walter

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
Xavier Roa-Mansergas, Rut Fadó, Maher Atari, Joan F. Mir, Helena Muley, Dolors Serra & Núria Casals

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.
Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmüller G, Elemento O, Gross SS, Suhre K.

Hypoxia / ischemia

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Zandra E. Walton, Chirag H. Patel, Rebekah C. Brooks, Yongjun Yu, Arig Ibrahim-Hashim, Malini Riddle, Alessandra Porcu, Tianying Jiang, Brett L. Ecker, Feven Tameire, Constantinos Koumenis, Ashani T. Weeraratna, David K. Welsh,  Robert Gillies, James C. Alwine, Lin Zhang, Jonathan D. Powell, Chi V. Dang

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity
Jimmy Zhang, Yves T. Wang, James H. Miller, Mary M. Day, Joshua C. Munger, Paul S. Brookes

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia
Amina M. Abdul-Aziz, Manar S. Shafat, Yu Sun, Christopher R. Marlein, Rachel E. Piddock, Stephen D. Robinson, Dylan R. Edwards, Zhigang Zhou, Angela Collins, Kristian M. Bowles & Stuart A. Rushworth

Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2
Jeffrey D. Bryant, Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang and Matthias Gromeier


IDH1 R132 mutant promotes tumor formation through downregulating p53
Bin Jiang, Wentao Zhao, Minggang Shi, Jia Zhang, Ai Chen, Huanhuan Ma, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Mengjue Liu, Shixiong Wen, Cong Ouyang, Huihui Wang, Xiumin Huang, Huamin Zhou and Qinxi  Li

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma
Joydeep Mukherjee, Tor-Christian Johannessen, Shigeo Ohba, Tracy T. Chow, Lindsey Jones, Ajay Pandita and Russell O. Pieper


mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
Long He, Ana P. Gomes, Xin Wang, Sang Oh Yoon, Gina Lee, Michal J. Nagiec, Sungyun Cho, Andre Chavez, Tasnia Islam, Yonghao Yu, John M. Asara, Bo Yeon Kim, John Blenis

The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting
Hall, D. T., Griss, T., Ma, J. F., Sanchez, B. J., Sadek, J., Tremblay, A. M. K., Mubaid, S., Omer, A., Ford, R. J., Bedard, N., Pause, A., Wing, S. S., Di Marco, S., Steinberg, G. R., Jones, R. G., Gallouzi, I.-E.

Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State
Jue Hou, Joshua Williams, Elliot L. Botvinick, Eric O. Potma and Bruce J. Tromberg

A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity
Cheng-Yang Wu, Santhosh Satapati, Wenjun Gui, Richard M. Wynn, Gaurav Sharma, Mingliang Lou, Xiangbing Qi, Shawn C. Burgess, Craig Malloy, Chalermchai Khemtong, A. Dean Sherry, David Chuang and Matthew E. Merritt


Cancer metabolism gets physical
Peter DelNero, Benjamin D. Hopkins, Lewis C. Cantley and Claudia Fischbach

Metabolic Hallmarks of Metastasis Formation
Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron
Peter S. J. Bailey and James A. Nathan


Metabolite Depletion Affects Flux Profiling of Cell Lines
A. Nilsson, J.R. Haanstra, B. Teusink, J. Nielsen

Metabolite regulates differentiation
Sophie Trefely, Kathryn E. Wellen

Acetyl-CoA-directed gene transcription in cancer cells
Inmaculada Martínez-Reyes and Navdeep S. Chandel

Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential
Michael J. Lukey, William P. Katt, Richard A. Cerione

Ribosomes on the night shift
Michel Nofal, Joshua D. Rabinowitz

Dual targeting of EGFR and glutaminase in lung cancer
Milica Momcilovic & David B. Shackelford

Nutrient availability dictates the regulation of metabolism by the ribosomal protein-MDM2-p53 pathway
Derek Franklin & Yanping Zhang

Asparagine, a critical limiting metabolite during glutamine starvation
Jie Jiang, Natalya N Pavlova & Ji Zhang

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron
Peter S. J. Bailey  and James A. Nathan

l-Lactate Transport and Metabolism in Mitochondria of Hep G2 Cells—The Cori Cycle Revisited
Salvatore Passarella and Avital Schurr

Pushing the Limits of Cancer Therapy: The Nutrient Game
Daniele Lettieri-Barbato and Katia Aquilano

Fructose fuels lung adenocarcinoma through GLUT5
Yuanyuan Weng, Jin Zhu, Zhenhong Chen, Jingqi Fu & Feng Zhang



MetaboList – April 2018

Metabolism and anti-cancer immunity

Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
Camila Rubio-Patiño, Jozef P. Bossowski , Gian Marco De Donatis, Laura Mondragón, Elodie Villa, Lazaro E. Aira, Johanna Chiche, Rana Mhaidly, Cynthia Lebeaupin, Sandrine Marchetti, Konstantinos Voutetakis, Aristotelis Chatziioannou, Florence A. Castelli, Patricia Lamourette, Emeline Chu-Van, François Fenaille, Tony Avril, Thierry Passeron, John B. Patterson, Els Verhoeyen, Béatrice Bailly-Maitre, Eric Chevet, Jean-Ehrland Ricci

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Tina Cascone,  Jodi A. McKenzie […], Patrick Hwu, Weiyi Peng

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Michael D. Kornberg, Pavan Bhargava, Paul M. Kim, Vasanta Putluri, Adele M. Snowman, Nagireddy Putluri, Peter A Calabresi, Solomon H. Snyder

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy
Srikanth Battu, Sumbul Afroz, Jeevan Giddaluru, Saima Naz, Weishan Huang, Saratchandra Singh Khumukcham, Rafiq Ahmad Khan, Saleem Yousuf Bhat, Insaf Ahmed Qureshi, Bramanandam Manavathi, Aleem Ahmed Khan, Avery August, Seyed Ehtesham Hasnain, Nooruddin Khan

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
Huilin Ye, Quanbo Zhou, Shangyou Zheng, Guolin Li, Qing Lin, Lusheng Wei, Zhiqiang Fu, Bin Zhang, Yimin Liu, Zhihua Li & Rufu Chen

Glucose metabolism

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Gang Xiao, Lai N. Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M. Weinstock, Thomas G. Graeber, Markus Müschen

HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang & Zhenhua Ding

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis
Francesca Ricciardiello, Giuseppina Votta, Roberta Palorini, Isabella Raccagni, Laura Brunelli, Alice Paiotta, Francesca Tinelli, Giuseppe D’Orazio, Silvia Valtorta, Luca De Gioia, Roberta Pastorelli, Rosa Maria Moresco, Barbara La Ferla & Ferdinando Chiaradonna

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC
Yan Tang, Hyokjoon Kwon, Brian A Neel, Michal Kasher-Meron, Jacob Pessin, Eijiro Yamada and Jeffrey E Pessin

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Thibault Houles, Simon-Pierre Gravel, Geneviève Lavoie, Sejeong Shin, Mathilde Savall, Antoine Méant, Benoit Grondin, Louis Gaboury, Sang-Oh Yoon, Julie St-Pierre, and Philippe P. Roux

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
Subhamoy Dasgupta, Kimal Rajapakshe, Bokai Zhu, Bryan C. Nikolai, Ping Yi, Nagireddy Putluri, Jong Min Choi, Sung Y. Jung, Cristian Coarfa, Thomas F. Westbrook, Xiang H.-F. Zhang, Charles E. Foulds, Sophia Y. Tsai, Ming-Jer Tsai & Bert W. O’Malley

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
Zhifen Zhou, Min Li, Lin Zhang, Hong Zhao, Özgür Şahin, Jing Chen, Jean J. Zhao, Zhou Songyang, and Dihua Yu

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
[pentose phosphate pathway]
Sarah A. Best, David P. De Souza, Ariena Kersbergen, Antonia N. Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H. Gray, Matthew E. Ritchie, Malcolm J. McConville, Kate D. Sutherland

Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer—effects of hypoxia
Ingrit Hamann, Daniel Krys, Darryl Glubrecht, Vincent Bouvet, Alison Marshall, Larissa Vos, John R. Mackey, Melinda Wuest, and Frank Wuest

Jaine K. Blayney, Lauren Cairns, Gerald Li, Niamh McCabe, Leanne Stevenson, Christopher J. Peters, Nathan B. Reid, Veronica J. Spence, Chintapuza Chisambo, Damian McManus, Jacqueline James, Stephen McQuaid,Stephanie Craig, Kenneth Arthur, Darragh McArt, Chin-Ann J. Ong, Pierre Lao-Sirieix, Peter Hamilton, Manuel Salto-Tellez, Martin Eatock, Helen G. Coleman, Rebecca C. Fitzgerald, Richard D. Kennedy, Richard C. Turkington, and  On behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

Po-Lin Tseng, Chih-Wei Chen, Keng-Hsun Hu, Hung-Chi Cheng, Yuan-Ho Lin, Wen-Hui Tsai, Tain-Junn Cheng,Wei-Hsuan Wu, Chin-Wei Yeh, Chin-Chih Lin, Hui-Ju Tsai, Hao-Chun Chang, Jiin-Haur Chuang, Yan-Shen Shan, and  Wen-Tsan Chang

Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2
Priya Londhe, Peter Y. Yu, Yuichi Ijiri, Katherine J. Ladner, Joelle M. Fenger, Cheryl London, Peter J. Houghton, and Denis C. Guttridge

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation
Lu Gong, Xiao Pan, Chuan-Bian Lim, Anna de Polo, John B. Little & Zhi-Min Yuan

Amino acid metabolism

Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
Maren Feist, Philipp Schwarzfischer, Paul Heinrich, Xueni Sun, Judith Kemper, Frederike von Bonin, Paula Perez-Rubio, Franziska Taruttis, Thorsten Rehberg, Katja Dettmer, Wolfram Gronwald, Jörg Reinders, Julia C. Engelmann, Jan Dudek, Wolfram Klapper, Lorenz Trümper, Rainer Spang, Peter J. Oefner & Dieter Kube

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza and Brian J. P. Huntly

Increased formate overflow is a hallmark of oxidative cancer
Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou & Alexei Vazquez

Lipid metabolism

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
Mark R. Lundquist, Marcus D. Goncalves, Ryan M. Loughran, Elite Possik, Tarika Vijayaraghavan, Annan Yang, Chantal Pauli, Archna Ravi, Akanksha Verma, Zhiwei Yang, Jared L. Johnson, Jenny C.Y. Wong, Yilun Ma, Katie Seo-Kyoung Hwang, David Weinkove, Nullin Divecha, John M. Asara, Olivier Elemento, Mark A. Rubin, Alec C. Kimmelman, Arnim Pause, Lewis C. Cantley, Brooke M. Emerling

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation
Cong-Hui Yao, Gao-Yuan Liu, Rencheng Wang, Sung Ho Moon, Richard W. Gross, Gary J. Patti

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis
Andras Ladanyi, Abir Mukherjee, Hilary A. Kenny, Alyssa Johnson, Anirban K. Mitra, Sinju Sundaresan , Kristin M. Nieman , Gloria Pascual , Salvador Aznar Benitah , Anthony Montag , S. Diane Yamada , Nada A. Abumrad & Ernst Lengyel

Uri Rozovski, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Alessandra Ferrajoli, Jan Burger, Phillip Thompson, Nitin Jain, William Wierda, Michael J. Keating,  and  Zeev Estrov[]=25066

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang

Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
Jiankai Liang, Li Guo, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin & Guangmei Yan

Satoshi Ogura, Yuichi Yoshida, Tomohide Kurahashi, Mayumi Egawa, Kunimaro Furuta, Shinichi Kiso, Yoshihiro Kamada, Hayato Hikita, Hidetoshi Eguchi, Hisakazu Ogita, Yuichiro Doki, Masaki Mori, Tomohide Tatsumi,  and  Tetsuo Takehara[]=24781

Nucleotides and one carbon metabolism

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma
Hideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii, Masahiro Tsuboi, Atsushi Ochiai, Hiroyasu Esumi, Takehiko Sasaki, Koichi Goto, and Katsuya Tsuchihara

One-carbon metabolism biomarkers and genetic variants in relation to colorectal cancer risk by KRAS and BRAF mutation status
Robin Myte , Björn Gylling, Jenny Häggström, Jörn Schneede, Anna Löfgren-Burström, Jeroen R. Huyghe, Göran Hallmans, Klaus Meyer, Ingegerd Johansson, Per Magne Ueland, Richard Palmqvist, Bethany Van Guelpen


Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations
Qiuying Chen, Kathryne Kirk, Yevgeniya I. Shurubor, Dazhi Zhao, Andrea J. Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L. Calder, Valerio Carelli, Travis T. Denton, M. Flint Beal, Steven S. Gross, Giovanni Manfredi, Marilena D’Aurelio

Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
Grace R. Anderson, Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell & Kris C. Wood

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect
Dan Li, Chaoqun Wang, Panfei Ma, Qingan Yu, Mingqi Gu, Liqian Dong, Wenjing Jiang, Shangha Pan, Changming Xie, Jihua Han, Yaliang Lan, Jing Sun, Ping Sheng, Kunpeng Liu, Yaohua Wu, Lianxin Liu, Yong Ma & Hongchi Jiang

Starvation / nutrient sensing

Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation
Ashish Kumar, Sagnik Giri, Chandrima Shaha

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms
[Glc deprivation inhibits autophagy]
Chinwendu Nwadike, Leon E. Williamson, Laura E. Gallagher, Jun-Lin Guan and Edmond Y. W. Chan

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
[Glc deprivation induces autophagy]
Xiaoyan Zhang, Leibin Wang, Behnam Lak, Jie Li, Eija Jokitalo, Yanzhuang Wang

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
Ruth Shiloh, Yuval Gilad, Yaara Ber, Miriam Eisenstein, Dina Aweida, Shani Bialik, Shenhav Cohen & Adi Kimchi

Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Giulia Allavena, Francesca Cuomo, Georg Baumgartner, Tadeja Bele, Alexander Yarar Sellgren, Kyaw Soe Oo, Kaylee Johnson, Vladimir Gogvadze, Boris Zhivotovsky & Vitaliy O Kaminskyy

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Marc J. Tol, Martijn J.C. van der Lienden, Tanit L. Gabriel, Jacob J. Hagen, Saskia Scheij, Tineke Veenendaal, Judith Klumperman, Wilma E. Donker-Koopman, Arthur J. Verhoeve, Hermen Overkleeft, Johannes M. Aerts, Carmen A. Argmann & Marco van Eijk

Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane
Hirofumi Ukai, Yasuhiro Araki, Shintaro Kira, Yu Oikawa, Alexander I. May, Takeshi Noda

FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction
Katarzyna Nowak, Avantika Gupta, Hugo Stocker

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation
Chi Kwan Tsang, Miao Chen, Xin Cheng, Yanmei Qi, Yin Chen, Ishani Das, Xiaoxing Li, Brinda Vallat, Li-Wu Fu, Chao-Nan Qian, Hui-Yun Wang, Eileen White, Stephen K. Burley, X.F. Steven Zheng

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
Toby A. Dite, Christopher G. Langendorf, Ashfaqul Hoque, Sandra Galic, Richard J. Rebello, Ashley J. Ovens, Lisa M. Lindqvist, Kevin R.W. Ngoei, Naomi X. Y. Ling, Luc Furic, Bruce E. Kemp, John Walter Scott and Jonathan S. Oakhill


Mutant IDH1 Promotes Glioma Formation In Vivo
Beatrice Philip, Diana X. Yu, Mark R. Silvis, Clifford H. Shin, James P. Robinson, Gemma L. Robinson, Adam E. Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua A. Sonnen, Matthew W. VanBrocklin, Richard J. Gibbons, Ryan E. Looper, Howard Colman, Sheri L. Holmen

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
Ovidiu C. Andronesi, Isabel C. Arrillaga-Romany, K. Ina Ly, Wolfgang Bogner, Eva M. Ratai, Kara Reitz, A. John Iafrate, Jorg Dietrich, Elizabeth R. Gerstner, Andrew S. Chi, Bruce R. Rosen, Patrick Y. Wen, Daniel P. Cahill & Tracy T. Batchelor

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Wei Qiang Ong, Hema Artee Luchman, J. Gregory Cairncross, Bo Huang, Russell O. Pieper, Joanna J. Phillips, and Sabrina M. Ronen

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola and Harley I. Kornblum

Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2–β-Catenin–BRG1 Transcriptional Network-Driven CD47 Expression
Pruthvi Gowda, Shruti Patrick, Ankita Singh, Touseef Sheikh and Ellora Sen

Wild-type and mutated IDH1/2 enzymes and therapy responses
Remco J. Molenaar, Jaroslaw P. Maciejewski, Johanna W. Wilmink & Cornelis J. F. van Noorden


LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response
Ji Hee Ha, Rangasudhagar Radhakrishnan, Muralidharan Jayaraman, Mingda Yan, Jeremy D. Ward, Kar-Ming Fung, Katherine Moxley, Anil K. Sood, Ciro Isidoro, Priyabrata Mukherjee, Yong Sang Song and Danny N. Dhanasekaran

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Yan Chen, Bo Zhang, Lei Bao, Lai Jin, Mingming Yang, Yan Peng, Ashwani Kumar, Jennifer E. Wang, Chenliang Wang, Xuan Zou, Chao Xing, Yingfei Wang, and Weibo Luo


Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
Jiska van der Reest, Sergio Lilla, Liang Zheng, Sara Zanivan & Eyal Gottlieb

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Jennifer Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Björn Kruspig, Ann Hedley, Gabriela Kalna, Sergio Lilla, Lisa Neilson, Martina Brucoli, Katarina Gyuraszova, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara R. Zanivan, and Daniel J. Murphy

Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
Chen Dai, Jennifer Arceo, James Arnold, Arun Sreekumar, Norman J. Dovichi, Jun Li and Laurie E. Littlepage

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
Wei Yan , Xiwei Wu , Weiying Zhou , Miranda Y. Fong , Minghui Cao ,Juan Liu , Xiaojing Liu ,Chih-Hong Chen , Oluwole Fadare, Donald P. Pizzo ,Jiawen Wu , Liang Liu ,Xuxiang Liu, Andrew R. Chin & &, Xiubao Ren ,Yuan Chen , Jason W. Locasale & Shizhen Emily Wang

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments
Christopher Ecker, Lili Guo, Stefana Voicu, Luis Gil-de-Gómez, Andrew Medvec, Luis Cortina, Jackie Pajda, Melanie Andolina, Maria Torres-Castillo, Jennifer L. Donato, Sarya Mansour, Evan R. Zynda, Pei-Yi Lin, Angel Varela-Rohena, Ian A. Blair, James L. Riley

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
Jianfeng Huang, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Elias A. Castilla, Timo D. Müller, Matthias H. Tschöp, Jorge Moscat, Maria T. Diaz-Meco

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues
Ayana Sasaki, Takahiro Nagatake, Riku Egami, Guoqiang Gu, Ichigaku Takigawa, Wataru Ikeda, Tomoya Nakatani, Jun Kunisawa, Yasuyuki Fujita


Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease
Raquel Buj and Katherine M. Aird

New links between lipid accumulation and cancer progression
Joseph T. Nickels Jr.

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
Russell A. DeBose-Boyd, Jin Ye

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
Simon-Pierre Gravel

Metabolic Reprogramming During Multidrug Resistance in Leukemias
Raphael Vidal, Julia Quarti, Franklin Rumjanek, and Vivian Rumjanek

Metabolic Reprogramming in Thyroid Carcinoma
Raquel Coelho, Rodrigo Fortunato, and Denise Carvalho

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo Salustiano, Luciana Gentile, Luciana Conde Rodrigues Maia, Alessandra Filardy, Tatiany Franklim, Kelli da Costa, Celio Freire-de-Lima, and Leonardo Freire-de-Lima

Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy
Sun-Hee Kim, Jason Roszik, Elizabeth Grimm, and Suhendan Ekmekcioglu

The Proline Cycle As a Potential Cancer Therapy Target.
Tanner JJ, Fendt SM, Becker DF.

Metabolic features of cancer stem cells: the emerging role of lipid metabolism
Rita Mancini, Alessia Noto, Maria Elena Pisanu, Claudia De Vitis, Marcello Maugeri-Saccà & Gennaro Ciliberto

Metabolomics and Isotope Tracing
Cholsoon Jang, Li Chen, Joshua D. Rabinowitz


Eating the Beast: Dietary Protein and Anticancer Immunity
Douglas R. Green

To Claim Growth Turf, mTOR Says SOD Off
Hyewon Kong, Navdeep S. Chandel

Immune Evasion in Tumor’s Own Sweet Way
Haidong Tang, Yang-Xin Fu

The Science and Translation of Lactate Shuttle Theory
George A. Brooks

Metabolic strugGLS after FLT3 inhibition in AML
Samuel J. Taylor and Ulrich Steidl

Breast cancer: Obesity: tipping the scales of resistance
Conor A. Bradley

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition
Sara Lovisa, Raghu Kalluri

MYC sets a tumour-stroma metabolic loop
Hilary A. Coller

When ER stress is bad for cancer

MetaboList – March 2018

Glycolysis and glycolytic enzymes

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth
Mami Morita, Taku Sato, Miyuki Nomura, Yoshimi Sakamoto, Yui Inoue, Ryota Tanaka, Shigemi Ito, Koreyuki Kurosawa, Kazunori Yamaguchi, Yuki Sugiura, Hiroshi Takizaki, Yoji Yamashita, Ryuichi Katakura, Ikuro Sato, Masaaki Kawai, Yoshinori Okada, Hitomi Watanabe, Gen Kondoh, Shoko Matsumoto, Ayako Kishimoto, Miki Obata, Masaki Matsumoto, Tatsuro Fukuhara, Hozumi Motohashi, Makoto Suematsu, Masaaki Komatsu, Keiichi I. Nakayama, Toshio Watanabe, Tomoyoshi Soga, Hiroshi Shima, Makoto Maemondo, Nobuhiro Tanuma

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism
Ramachandran Rashmi, Xiaojing Huang, John M. Floberg, Adnan E. Elhammali, Michael L. McCormick, Gary J. Patti, Douglas R. Spitz and Julie K. Schwarz

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
Natthakan Thongon, Chiara Zucal, Vito Giuseppe D’Agostino, Toma Tebaldi, Silvia Ravera, Federica Zamporlini, Francesco Piacente, Ruxanda Moschoi, Nadia Raffaelli, Alessandro Quattrone, Alessio Nencioni, Jean-Francois Peyron and Alessandro Provenzani

Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4
Wenzhi Jia, Xiaoping Zhao, Li Zhao, Hui Yan, Jiajin Li, Hao Yang, Gang Huang & Jianjun Liu

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein
Tsu-Yao Cheng, Yi-Chieh Yang, Hsiu-Po Wang, Yu-Wen Tien, Chia-Tung ShunHsin-Yi Huang,Michael Hsiao & Kuo-Tai Hua

Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors
Raeeka Khamari, Anne Trinh, Pierre Elliott Gabert, Paola Corazao-Rozas, Samuel Riveros-Cruz, Stephane Balayssac, Myriam Malet-Martino, Salim Dekiouk, Marie Joncquel Chevalier Curt, Patrice Maboudou, Guillaume Garçon, Laura Ravasi, Pierre Guerreschi, Laurent Mortier, Bruno Quesnel, Philippe Marchetti & Jerome Kluza

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye

Craig S. Richmond, Darby Oldenburg, Garrett Dancik, David R. Meier, Benjamin Weinhaus, Dan Theodorescu,  and  Sunny Guin

Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4
Li Wang, Jing-jing Li, Li-yu Guo, Peipei Li, Zhiqiang Zhao,  Haisheng Zhou & Li-jun Di

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Annemarie Schwab, Aarif Siddiqui, Maria Eleni Vazakidou, Francesca Napoli, Martin Böttcher, Bianca Menchicchi, Umar Raza, Özge Saatci, Angela M. Krebs, Fulvia Ferrazzi, Ida Rapa, Katja Dettmer-Wilde, Maximilian J. Waldner, Arif B. Ekici, Suhail Ahmed Kabeer Rasheed, Dimitrios Mougiakakos, Peter J. Oefner, Ozgur Sahin, Marco Volante, Florian R. Greten, Thomas Brabletz and Paolo Ceppi

Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer
Nicoletta Caronni, Francesca Simoncello, Francesca Stafetta, Corrado Guarnaccia, Juan Sebastian Ruiz-Moreno, Bastian Opitz, Thierry Galli, Veronique Proux-Gillardeaux and Federica Benvenuti

Amino acids

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism
Xia Gao, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, Jason W. Locasale

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo
Hien Anh Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic, Michael Caffrey, Amanda M. Schalk, Li Liu, Damiano Rondelli, Annie Oh, Dolores L. Mahmud, Maarten C. Bosland, Andre Kajdacsy-Balla, Sofie Peirs, Tim Lammens, Veerle Mondelaers, Barbara De Moerloose, Steven Goossens, Michael J. Schlicht, Kasim K. Kabirov, Alexander V. Lyubimov, Bradley J. Merrill, Yogen Saunthararajah, Pieter Van Vlierberghe and Arnon Lavie

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent
Tingting Wang, Lingling Liu, Xuyong Chen, Yuqing Shen, Gaojian Lian, Nilay Shah, Andrew M Davidoff, Jun Yang & Ruoning Wang

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
Marta Mauro-Lizcano & Abelardo López-Rivas

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant

Lipid metabolism

Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang

Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
Yongtao Wang, Yixin Chen, Lihuan Guan, Huizheng Zhang, Yaoyao Huang, Caroline H. Johnson, Zeming Wu, Frank J. Gonzalez, Aiming Yu,Peng Huang, Ying Wang, Shouhui Yang, Pan Chen, Xiaomei Fan, Min Huang & Huichang Bi

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Yang-An Wen, Xiaopeng Xiong, Yekaterina Y. Zaytseva, Dana L. Napier, Emma Vallee, Austin T. Li, Chi Wang, Heidi L. Weiss, B. Mark Evers & Tianyan Gao


A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Marcus J. G. W. Ladds , Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson […] Sonia Laín


Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells
Ryo Yonashiro, Kayoko Eguchi, Masaki Wake, Norihiko Takeda and Koh Nakayama

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
Meng-Xi Liu, Lei Jin, Si-Jia Sun, Peng Liu, Xu Feng Zhou-Li Cheng, Wei-Ren Liu, Kun-Liang Guan, Ying-Hong Shi, Hai-Xin Yuan & Yue Xiong

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant & Olivier Feron

Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells
Shuyan Wang, Xiaohai Shi, Shuang Wei, Ding Ma, Olutobi Ajala, Sheng-Qing Lv, Mingyao Ying, Yu Alex Zhang, Steven Michael Claypool, Paul Watkins and Shuli Xia

AMPK family

Colorectal tumors require NUAK1 for protection from oxidative stress
Jennifer L. F. Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Bjorn Kruspig, Ann Hedley, Gabriela Kalna, Sergio Lilla, Lisa Neilson, Martina Brucoli, Katarina Gyuraszova, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara Zanivan and Daniel J. Murphy

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation
Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A. Balaji, Prashant Kumar, Sravanth K. Hindupur and Annapoorni Rangarajan


Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu& David M. Sabatini

Architecture of the human mTORC2 core complex
Edward Stuttfeld, Christopher HS Aylett,  Stefan Imseng,  Daniel Boehringer, Alain Scaiola,  Evelyn Sauer, Michael N Hall, Timm Maier, Nenad Ban

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth
Jianjun Zhang , Jianping Guo, Xing Qin, Bin Wang, Linli Zhang, Yingnan Wang, Wenjian Gan, Pier Paolo Pandofi, Wantao Chen, Wenyi Wei

Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival
Thomas A. Werfel, Shan Wang, Meredith A. Jackson, Taylor E. Kavanaugh, Meghan Morrison Joly, Linus H. Lee, Donna J. Hicks, Violeta Sanchez, Paula Gonzalez Ericsson, Kameron V. Kilchrist, Somtochukwu C. Dimobi, Samantha M. Sarett, Dana M. Brantley-Sieders, Rebecca S. Cook and Craig L. Duvall

Starvation, angiogenesis

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, Michael R. MacArthur, Abhirup Das, J. Humberto Treviño-Villarreal, Christopher Hine, Issam Ben-Sahra, Nelson H. Knudsen, Lear E. Brace, Justin Reynolds, Pedro Mejia, Ming Tao, Gaurav Sharma, Rui Wang, Jean-Marc Corpataux, Jacques-Antoine Haefliger, Kyo Han Ahn, Chih-Hao Lee, Brendan D. Manning, David A. Sinclair, Christopher S. Chen, C. Keith Ozaki, James R. Mitchell

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
Annan Yang, Grit Herter-Sprie, Haikuo Zhang, Elaine Y. Lin, Douglas Biancur, Xiaoxu Wang, Jiehui Deng, Josephine Hai, Shenghong Yang, Kwok-Kin Wong and Alec C. Kimmelman

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter & Albert R. La Spada

Glucose Starvation Increases V-ATPase Assembly and Activity in Mammalian Cells through AMP Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling
Christina M. McGuire and Michael Forgac

PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Higinio Dopeso, Hui-Ke Jiao, Angel M. Cuesta, Anne-Theres Henze, Liane Jurida, Michael Kracht, Amparo Acker-Palmer, Boyan K.Garvalov and Till Acker


Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases
Arnaud Blomme, Gaetan Van Simaeys, Gilles Doumont, Brunella Costanza, Justine Bellier, Yukihiro Otaka, Félicie Sherer, Pierre Lovinfosse, Sébastien Boutry, Ana Perez Palacios, Edwin De Pauw, Touko Hirano, Takehiko Yokobori, Roland Hustinx, Akeila Bellahcène, Philippe Delvenne, Olivier Detry, Serge Goldman, Masahiko Nishiyama, Vincent Castronovo & Andrei Turtoi

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
Lifeng Li, Liping Wang, Jieyao Li, Zhirui Fan, Li Yang, Zhen Zhang, Chaoqi Zhang, Dongli Yue, Guohui Qin, Tengfei Zhang, Feng Li, Xinfeng Chen, Yu Ping, Dan Wang, Qun Gao, Qianyi He, Lan Huang, Hong Li, Jianmin Huang, Xuan Zhao, Wenhua Xue, Zhi Sun, Jingli Lu, Jane J. Yu, Jie Zhao, Bin Zhang and Yi Zhang

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
Ching-Wen Chang, Yu-Syuan Chen, Yeou-Guang Tsay, Chia-Li Han, Yu-Ju Chen, Cheng-Chieh Yang, Kai-Feng Hung, Chao-Hsiung Lin, Tsung-Yen Huang, Shou-Yen Kao, Te-Chang Lee & Jeng-Fan Lo

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova-Kostova, Richard C. Hartley, Michael P. Murphy& Luke A. O’Neill

Unravelling the metabolic progression of breast cancer cells to bone metastasis by coupling Raman spectroscopy and a novel use of MCR-ALS algorithm
Monica Marro, Claudia Nieva, Anna De Juan, and Angels Sierra


Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response
Sophia Y. Lunt, Sarah-Maria Fendt

Metabolic exhaustion in infection, cancer and autoimmunity
E. F. McKinney & K. G. C. Smith

The Role of Mitochondrial H+-ATP Synthase in Cancer
Pau Esparza-Moltó, and Jose Cuezva

The carnitine system and cancer metabolic plasticity
Melone Mariarosa Anna Beatrice, Valentino Anna, Margarucci Sabrina, Galderisi Umberto, Giordano Antonio

Targeting angiogenic metabolism in disease
Xuri Li, Peter Carmeliet

Crosstalks between translation and metabolism in cancer
Stefano Biffo, Nicola Manfrini, Sara Ricciardi

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer
Lisa M Lindqvist, Kristofferson Tandoc, Ivan Topisirovic, Luc Furic

Metabolic Kinases Moonlighting as Protein Kinases
Zhimin Lu, Tony Hunter

Extracellular matrix internalization links nutrient signalling to invasive migration
Elena Rainero


Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues
Annamarie E. Allen, Jason W. Locasale

Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
Estela Noguera-Ortega and Ravi K. Amaravadi

Asparagine Bioavailability Drives Breast Cancer Metastasis

MetaboList – February 2018

Amino acids / nucleotides
Asparagine bioavailability governs metastasis in a model of breast cancer
Simon R. V. Knott, Elvin Wagenblast, Showkhin Khan, Sun Y. Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, Clive S. D’Santos, Lisa A. Carey, John E. Wilkinson, J. Chuck Harrell, Charles M. Perou, Hani Goodarzi, George Poulogiannis & Gregory J. Hannon
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Michael L Schulte, Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T Smith, Jumpei Kondo, Robert J Coffey, Marc O Johnson, Jeffrey C Rathmell, Joe T Sharick, Melissa C Skala, Jarrod A Smith, Jordan Berlin, M Kay Washington, Michael L Nickels & H Charles Manning
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
Denise R. Minton, Minwoo Nam, Daniel J. McLaughlin, Jong Shin, Erol C. Bayraktar, Samantha W. Alvarez, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, David M. Sabatini, Kıvanç Birsoy, Richard Possemato
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu, Ji-Lin Wang, Tian-Hui Zou, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen & Jing-Yuan Fang
Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition
Seungyeon Yang, Sunsook Hwang, Minjoong Kim, Sung Bin Seo, Jeong-Hwa Lee & Seung Min Jeong
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Karina N. Gonzalez Herrera, Elma Zaganjor, Yoshinori Ishikawa, Jessica B. Spinelli, Haejin Yoon, Jia-Ren Lin, F. Kyle Satterstrom, Alison Ringel, Stacy Mulei, Amanda Souza, Joshua M. Gorham, Craig C. Benson, Jonathan G. Seidman, Peter K. Sorger, Clary B. Clish, Marcia C. Haigis
Glycolysis and PPP
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
Dongxin Zhao, Mehmet G. Badur, Jens Luebeck, Jose H. Magaña, Amanda Birmingham, Roman Sasik, Christopher S. Ahn, Trey Ideker, Christian M. Metallo, Prashant Mali
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
Xiaoyu Ma, Xiaoyu Ma, Lin Wang, Lin Wang, De Huang, De Huang, Yunyan Li, Yunyan Li, Dongdong Yang, Dongdong Yang, Tingting Li, Tingting Li, Fudong Li, Fudong Li, Linchong Sun, Linchong Sun, Haoran Wei, Haoran Wei, Kun He, Kun He, Fazhi Yu, Fazhi Yu, Debiao Zhao, Debiao Zhao, Lan Hu, Lan Hu, Songge Xing, Songge Xing, Zhaoji Liu, Zhaoji Liu, Kui Li, Kui Li, Jing Guo, Jing Guo, Zhenye Yang, Zhenye Yang, Xin Pan, Xin Pan, Ailing Li, Ailing Li, Yunyu Shi, Yunyu Shi, Junfeng Wang, Junfeng Wang, Ping Gao, Ping Gao, Huafeng Zhang
A Mathematical Model for Enzyme Clustering in Glucose Metabolism
Miji Jeon, Hye-Won Kang & Songon An
Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells
Touseef Sheikh, Piyushi Gupta, Pruthvi Gowda, Shruti Patrick and Ellora Sen
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan & Hai-Xin Yuan
The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose
Xiang Li, Shichang Deng, Mingliang Liu, Yan Jin, Shuai Zhu, Shijiang Deng, Jingyuan Chen, Chi He, Qi Qin, Chunyou Wang & Gang Zhao
SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization
Yuanyuan Weng, Xueyu Fan, Yongfeng Bai, Siwei Wang, Hui Huang, Huimin Yang, Jin Zhu & Feng Zhang
IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Hong Xie, Chih-Hang Anthony Tang, Jun H. Song, Anthony Mancuso, Juan R. Del Valle, Jin Cao, Yan Xiang,Chi V. Dang, Roy Lan, Danielle J. Sanchez, Brian Keith, Chih-Chi Andrew Hu, and M. Celeste Simon
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Ming Chen, Jiangwen Zhang, Katia Sampieri, John G. Clohessy, Lourdes Mendez, Enrique Gonzalez-Billalabeitia, Xue-Song Liu, Yu-Ru Lee, Jacqueline Fung, Jesse M. Katon, Archita Venugopal Menon, Kaitlyn A. Webster, Christopher Ng, Maria Dilia Palumbieri, Moussa S. Diolombi, Susanne B. Breitkopf, Julie Teruya-Feldstein, Sabina Signoretti, Roderick T. Bronson, John M. Asara, Mireia Castillo-Martin, Carlos Cordon-Cardo & Pier Paolo Pandolfi
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D’Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero, Nicolas Delaleu, Andrea Rinaldi, Francesco Bertoni, Johann de Bono, Arkaitz Carracedo & Andrea Alimonti
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
Silvia Escudero, Elma Zaganjor, Susan Lee, Christopher P. Mill, Ann M. Morgan, Emily B. Crawford, Jiahao Chen, Thomas E. Wales, Rida Mourtada, James Luccarelli, Gregory H. Bird, Ulrich Steidl, John R. Engen, Marcia C. Haigis, Joseph T. Opferman, Loren D. Walensky
Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
Bandish Kapadia, Nahid M. Nanaji, Kavita Bhalla, Binny Bhandary, Rena Lapidus, Afshin Beheshti, Andrew M. Evens & Ronald B. Gartenhaus
Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer
W Han, S Gao, D Barrett, M Ahmed, D Han, J A Macoska, H H He and C Cai
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation
V L Sodi, Z A Bacigalupa, C M Ferrer, J V Lee, W A Gocal, D Mukhopadhyay, K E Wellen, M Ivan & M J Reginato
LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu and Shuzhong Yao
A Metabolic Basis for Endothelial-to-Mesenchymal Transition
Jianhua Xiong, Hiroyuki Kawagishi, Ye Yan, Jie Liu, Quinn S. Wells, Lia R. Edmunds, Maria M. Fergusson, Zu-Xi Yu, Ilsa I. Rovira, Evan L. Brittain, Michael J. Wolfgang, Michael J. Jurczak, Joshua P. Fessel, Toren Finkel
Metabolic Profile of Oral Squamous Carcinoma Cell Lines Relies on a Higher Demand of Lipid Metabolism in Metastatic Cells
Ana Carolina Sant´Anna-Silva, Gilson Costa dos Santos Junior, Samir Campos, Andre Gomes, Juan Pérez-Valencia, and Franklin Rumjanek
Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Kiran Kurmi, Sadae Hitosugi, Elizabeth K. Wiese, Felix Boakye-Agyeman, Wilson I. Gonsalves, Zhenkun Lou, Larry M. Karnitz, Matthew P. Goetz, Taro Hitosugi
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
Edoardo Gaude, Christina Schmidt, Payam A. Gammage, Aurelien Dugourd, Thomas Blacker, Sew Peak Chew, Julio Saez-Rodriguez, John S. O’Neill, Gyorgy Szabadkai, Michal Minczuk, Christian Frezza
Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53
Giuseppe Arena, Madi Yann Cissé, Samuel Pyrdziak, Laurent Chatre, Romain Riscal, Maryse Fuentes, Jamie Jon Arnold, Markus Kastner, Laurie Gayte, Christelle Bertrand-Gaday, Kevin Nay, Claire Angebault-Prouteau, Kerren Murray, Beatrice Chabi, Christelle Koechlin-Ramonatxo, Béatrice Orsetti, Charles Vincent, François Casas, Jean-Christophe Marine, Sandrine Etienne-Manneville, Florence Bernex, Anne Lombès, Craig Eugene Cameron, Hervé Dubouchaud, Miria Ricchetti, Laetitia Karine Linares, Laurent Le Cam
Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer
Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun, Guowang Xu
Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α
Subhasree Basu, Keerthana Gnanapradeepan, Thibaut Barnoud, Che-Pei Kung, Michele Tavecchio, Jeremy Scott, Andrea Watters, Qing Chen, Andrew V. Kossenkov and Maureen E. Murphy
Hypoxia and HIFs
Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Felipe Paredes, Kely Sheldon, Bernard Lassègue, Holly C. Williams, Elizabeth A. Faidley, Gloria A. Benavides, Gloria Torres, Fernanda Sanhueza-Olivares, Samantha M. Yeligar, Kathy K. Griendling, Victor Darley-Usmar, and Alejandra San Martin
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu & Q Liu
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong & Yi Fan
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
D A Almiron Bonnin, M C Havrda, M C Lee, H Liu, Z Zhang, L N Nguyen, L X Harrington, S Hassanpour, C Cheng & M A Israel
The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling
Robert B. Jones, Kaitlyn A. Dorsett, Anita B Hjelmeland and Susan L. Bellis
FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes
Jengmin Kang, Seung-Hyun Shin, Haejin Yoon, June Huh, Hyun-Woo Shin, Yang-Sook Chun and Jong-Wan Park
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect
Shaoxun Xiang, Hao Gu, Lei Jin, Rick F. Thorne, Xu Dong Zhang, and Mian Wu
Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver
Inna A. Nikonorova, Emily T. Mirek, Christina C. Signore, Michael P. Goudie, Ronald C. Wek and Tracy G. Anthony
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk & Eddine Saiah
The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
Xiaoduo Xie, Hongli Hu, […] Daming Gao
AMPK family
Phosphorylation of Cdc25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell cycle G2/M phase transition
Yuqing Shen, John William Sherman, Xuyong Chen and Ruoning Wang
Calcium signalling links MYC to NUAK1
T Monteverde, J Tait-Mulder, A Hedley, J R Knight, O J Sansom & D J Murphy
AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress
Alain Kfoury, Marzia Armaro, Caterina Collodet, Jessica Sordet‐Dessimoz, Maria Pilar Giner, Stefan Christen, Sofia Moco, Marion Leleu, Laurence de Leval, Ute Koch, Andreas Trumpp, Kei Sakamoto, Friedrich Beermann and Freddy Radtke
Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency
Jiaqi Gong, Haifeng Gu, Lin Zhao, Liang Wang, Pinglei Liu, Fuping Wang, Haoyu Xu & Tongbiao Zhao
Kinase Activity Determination of Specific AMPK Complexes/Heterotrimers in the Skeletal Muscle
Jesper B. Birk, Jørgen F. P. Wojtaszewski
Starvation, drugs
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
[amino acid deprivation]
Jun Zhou, Ji Wan, Xin Erica Shu, Yuanhui Mao, Xiao-Min Liu, Xin Yuan, Xingqian Zhang, Martin E. Hess, Jens C. Brüning, Shu-Bing Qian
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism
E Cuyàs, S Fernández-Arroyo, S Verdura, R Á-F García, J Stursa, L Werner, E Blanco-González, M Montes-Bayón, J Joven, B Viollet, J Neuzil & J A Menendez
Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins
Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Peter J. Mullen, Wail Ba-Alawi, Benjamin Haibe-Kains and Linda Z. Penn
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth
D Ma, X Chen, P-Y Zhang, H Zhang, L-J Wei, S Hu, J-Z Tang, M-T Zhou, C Xie, R Ou, Y Xu & K-F Tang
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis
Xinshou Ouyang, Sheng-Na Han, Ji-Yuan Zhang, Balazs Tamas Nemeth, Pal Pacher, Dechun Feng, Ramon Bataller, Joaquin Cabezas, Peter Stärkel, Joan Caballeria, Rebecca LePine Pongratz, Shi-Ying Cai, Bernd Schnabl, Rafaz Hoque, Yonglin Chen, Wei-hong Yang, Irma Garcia Martinez, Fu-Sheng Wang, Bin Gao, Natalie Julia Torok, Richard Glenn Kibbey, Wajahat Zafar Mehal
Nathaniel Edward Bennett Saidu, Marie Bretagne, Audrey Lupo Mansuet, Pierre-Alexandre Just, Karen Leroy,Olivier Cerles, Sandrine Chouzenoux, Carole Nicco, Diane Damotte, Marco Alifano, Bruno Borghese, François Goldwasser, Frédéric Batteux,  and  Jérôme Alexandre
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli & Giuseppina Caretti
Advances in Hypoxia-Inducible Factor Biology
Hani Choudhry, Adrian L. Harris
Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
Adam J. Wolpaw, Chi V. Dang
From the unfolded protein response to metabolic diseases – lipids under the spotlight
Nurulain Ho, Chengchao Xu and Guillaume Thibault
Ketogenic diet in cancer therapy
Daniela D. Weber, Sepideh Aminazdeh-Gohari, Barbara Kofler
Endothelial Cell Metabolism in Health and Disease
Katerina Rohlenova, Koen Veys, Ines Miranda-Santos, Katrien De Bock, Peter Carmeliet
FOXO Family in regulating Cancer and Metabolism
Ma J1, Matkar S2, He X3, Hua X4.
B-Cell Metabolic Remodeling and Cancer
Davide G. Franchina, Melanie Grusdat, Dirk Brenner
Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates
Dan Ye, Kun-Liang Guan, Yue Xiong
Metabolism in pluripotency: Both driver and passenger?
Perrine Dahan, Vivian Lu, Robert M.T. Nguyen, Stephanie A.L. Kennedy and Michael A. Teitell
Aberrant lipid metabolism in cancer cells – the role of oncolipid‐activated signaling
Upasana Ray, Sib Sankar Roy
DNA Damage, Repair, and Cancer Metabolism
Marc-Olivier Turgeon, Nicholas J. S. Perry and George Poulogiannis
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Marco B. Schaaf, Abhishek D. Garg & Patrizia Agostinis
Metabolism and TAM functions—it takes two to tango
Massimiliano Mazzone, Alessio Menga and Alessandra Castegna
Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy
Chiara Porta, Antonio Sica and Elena Riboldi
Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
Gopinath Prakasam, Mohammad Iqbal, Rameshwar Bamezai, and Sybille Mazurek
Comments, other
The Sympathetic Nervous System Drives Tumor Angiogenesis
Hubert Hondermarck, Phillip Jobling
m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress
Emily Nicole Powers, Gloria Ann Brar
Genetics of lipid metabolism in prostate cancer
Ninu Poulose, Francesca Amoroso, Rebecca E. Steele, Reema Singh, Chee Wee Ong & Ian G. Mills
Glutamine metabolism, the Achilles heel for medulloblastoma tumor
Maria Victoria Niklison-Chirou
GCN2 controls the cellular checkpoint: potential target for regulating inflammation
Xiaojing Xia, Liancheng Lei, Wanhai Qin, Lei Wang, Gaiping Zhang & Jianhe Hu
The interplay between mutant p53 and the mevalonate pathway
Alejandro Parrales, Elizabeth Thoenen & Tomoo Iwakuma
Free Webinar: Oxygen Sensing in Cancer and Metabolism
Speakers: Celeste Simon, Cullen Taniguchi and Othon Iliopoulos.

MetaboList – January 2018

Amino acids

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
Dana M. Gwinn, Alex G. Lee, Marcela Briones-Martin-del-Campo, Crystal S. Conn, David R. Simpson, Anna I. Scott, Anthony Le, Tina M. Cowan, Davide Ruggero, E. Alejandro Sweet-Cordero

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
Natalya N. Pavlova, Sheng Hui, Jonathan M. Ghergurovich, Jing Fan, Andrew M. Intlekofer, Richard M. White, Joshua D. Rabinowitz, Craig B. Thompson, Ji Zhang

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero & Jim C. Norman

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
Xin Yang, Zhe Wang, Xin Li, Boya Liu, Minghui Liu, Lu Liu, Shuaiyi Chen, Mengmeng Ren, Yankun Wang, Miao Yu, Bo Wang, Junhua Zou, Wei-Guo Zhu, Yuxin Yin, Wei Gu and Jianyuan Luo

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yanhui Xu, Wei Xu, Shi-Min Zhao

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
Qingqiu Huang, Clint Stalnecker, Chengliang Zhang, Lee A. McDermott, Prema Iyer, Jason O’Neill, Shawn Reimer, Richard A. Cerione and William P. Katt

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Yann Cormerais, Pierre André Massard, Milica Vucetic, Sandy Giuliano, Eric Tambutté, Jerome Durivault, Valérie Vial, Hitoshi Endou, Michael F. Wempe, Scott K. Parks and Jacques Pouyssegur

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker & Renae M Ryan

Glucose, lactate

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher P. Long, Maciek R. Antoniewicz & Nissim Hay

Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
K Diehl, L-A Dinges, O Helm, N Ammar, D Plundrich, A Arlt, C Röcken, S Sebens & H Schäfer

Coordinated Regulation of Intracellular pH by Two Glucose Sensing Pathways in Yeast
Daniel G. Isom, Stephani C. Page, Leonard B. Collins, Nicholas J. Kapolka, Geoffrey J. Taghon and Henrik G. Dohlman

Zheng-Xiao Zhao, Lin-Wei Lu, Jian Qiu, Qiu-Ping Li, Fei Xu, Bao-Jun Liu, Jing-Cheng Dong,  and  Wei-Yi Gong

NAD, NADP, nucleotides

Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Xu Qian, Xinjian Li, Lin Tan, Jong-Ho Lee, Yan Xia, Qingsong Cai, Yanhua Zheng, Hongxia Wang, Philip L. Lorenzi and Zhimin Lu

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors
Wenyun Lu, Lin Wang, Li Chen, Sheng Hui, and Joshua D. Rabinowitz

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
Michael T McCarthy, Gerald Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Valli, Tomoyoshi Soga, Julie Adam and Christopher A O’Callaghan


Alfredo Caro-Maldonado, Laura Camacho, Amaia Zabala-Letona, Verónica Torrano, Sonia Fernández-Ruiz, Kepa Zamacola-Bascaran, Leire Arreal, Lorea Valcárcel-Jiménez, Natalia Martín-Martín, Juana M. Flores, Ana R. Cortazar, Patricia Zúñiga-García, Amaia Arruabarrena-Aristorena, Fabienne Guillaumond, Diana Cabrera, Juan M. Falcón-Perez, Ana M. Aransay, Antonio Gomez-Muñoz, Mireia Olivan, Juan Morote,  and  Arkaitz Carracedo

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
Tianyi Wang, Johannes Francois Fahrmann, Heehyoung Lee, Yi-Jia Li, Satyendra C. Tripathi, Chanyu Yue, Chunyan Zhang, Veronica Lifshitz, Jieun Song, Yuan Yuan, George Somlo, Rahul Jandial, David Ann, Samir Hanash, Richard Jove, Hua Yu

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER
Jonathan R. Friedman, Muthukumar Kannan, Alexandre Toulmay, Calvin H. Jan, Jonathan S. Weissman, William A. Prinz, Jodi Nunnari

Hypoxia, HIF

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia
Xiaodong Zhang, Alicia M Saarinen, Taro Hitosugi, Zhenghe Wang, Liguo Wang, Thai H Ho, Jun Liu

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
Jolieke G. van Oosterwijk, Daelynn R. Buelow, Christina D. Drenberg, Aksana Vasilyeva, Lie Li, Lei Shi, Yong-Dong Wang, David Finkelstein, Sheila A. Shurtleff, Laura J. Janke, Stanley Pounds, Jeffrey E. Rubnitz, Hiroto Inaba, Navjotsingh Pabla, and Sharyn D. Baker

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL
Ji Ae Kim, Da Kyung Choi, Jung Sun Min, Inho Kang, Jin Chul Kim, Semi Kim and Jeong Keun Ahn

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice
Claire-Sophie Devignes, Yetki Aslan, Audrey Brenot, Audrey Devillers, Koen Schepers, Stéphanie Fabre, Jonathan Chou, Amy-Jo Casbon, Zena Werb, and Sylvain Provot

HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis
Hui-Huang Lai, Jie-Ning Li, Ming-Yang Wang, Hsin-Yi Huang, Carlo M. Croce, Hui-Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching-Feng Chiu, Mien-Chie Hung, Hiroshi I. Suzuki, and Pai-Sheng Chen


Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis
Ha Yin Lee , Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H. Shawn Je, Egon Ogris, David M. Virshup, Koji Itahana

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
Xiao-xue Li, Zhi-jing Wang, Yu Zheng, Yun-feng Guan, Peng-bo Yang, Xiang Chen, Cong Peng, Jian-ping He, Yuan-li Ai, Sheng-fu Wu, Kun-Yi Chien, Qiao Wu, Hang-zi Chen

TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation
Lei Sun, Zhaoyue Meng, Yifei Zhu, Jun Lu, Zhichao Li et al.

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy
Heeseon An & J. Wade Harper

Lipid droplet biogenesis is spatially coordinated at ER–vacuole contacts under nutritional stress
Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J Ryan Feathers and W Mike Henne

Glucose deprivation induces primary cilium formation through mTORC1 inactivation
Kengo Takahashi, Tomoaki Nagai, Shuhei Chiba, Keiko Nakayama and Kensak Mizuno

Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms
L-N Fu, Y-Q Wang, J Tan, J Xu, Q-Y Gao, Y-X Chen& J-Y Fang

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin
Avinash Persaud, Yann Cormerais, Jacques Pouyssegur and Daniela Rotin

Puromycin labeling does not allow protein synthesis to be measured in energy-starved cells
Ran Marciano, Gabriel Leprivier & Barak Rotblat

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, Scott J. Dixon


A metabolic function of FGFR3-TACC3 gene fusions in cancer
Véronique Frattini, Stefano M. Pagnotta, Tala, Jerry J. Fan, Marco V. Russo, Sang Bae Lee, Luciano Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M. Castano, Luigi Cerulo, Delphine C. M. Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S. J. Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella & Antonio Iavarone

Mitochondria are physiologically maintained at close to 50 °C
Dominique Chrétien, Paule Bénit, Hyung-Ho Ha, Susanne Keipert, Riyad El-Khoury, Young-Tae Chang, Martin Jastroch, Howard T. Jacobs, Pierre Rustin, Malgorzata Rak

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance
Allyson L. Anding, Chunxin Wang, Tsun-Kai Chang, Danielle A. Sliter, Christine M. Powers, Kay Hofmann, Richard J. Youle, Eric H. Baehrecke

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra


mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
Marta Brandt, Tatiana P. Grazioso, Mohamad-Ali Fawal, Krishna S. Tummala, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Cristian Perna, Nabil Djouder

Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases
Kim Hou Chia, Tomoyuki Fukuda, Fajar Sofyantoro, Takato Matsuda, Takamitsu Amai, Kazuhiro Shiozaki

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer
Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Avi Kumar, Guojing Zhang, Youna Ha, Dan Li, Gina N. Alesi, Yibin Kang, Lu Zhou, Wen-Mei Yu, Kelly R. Magliocca, Fadlo R. Khuri, Cheng-Kui Qu, Christian Metallo, Taofeek K. Owonikoko, Sumin Kang


R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Rui Su, Lei Dong, Chenying Li, Sigrid Nachtergaele, Mark Wunderlich, Ying Qing, Xiaolan Deng, Yungui Wang, Xiaocheng Weng, Chao Hu, Mengxia Yu, Jennifer Skibbe, Qing Dai, Dongling Zou, Tong Wu, Kangkang Yu, Hengyou Weng, Huilin Huang, Kyle Ferchen, Xi Qin, Bin Zhang, Jun Qi, Atsuo T. Sasaki, David R. Plas, James E. Bradner, Minjie Wei, Guido Marcucci, Xi Jiang, James C. Mulloy, Jie Jin, Chuan He, Jianjun Chen

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner and Hai Yan


A Landscape of Metabolic Variation across Tumor Types
Ed Reznik, Augustin Luna, Bulent Arman Aksoy, Eric Minwei Liu, Konnor La, Irina Ostrovnaya, Chad J. Creighton, A. Ari Hakimi, Chris Sander

Fenofibrate prevents skeletal muscle loss in mice with lung cancer
Marcus D. Goncalves, Seo-Kyoung Hwang, Chantal Pauli, Charles J. Murphy, Zhe Cheng, Benjamin D. Hopkins, David Wu, Ryan M. Loughran, Brooke M. Emerling, Guoan Zhang, Douglas T. Fearon and Lewis C. Cantley

Tushar H. More, Sourav RoyChoudhury, Joel Christie, Khushman Taunk, Anupama Mane, Manas K. Santra, Koel Chaudhury,  and  Srikanth Rapole


AMPK: guardian of metabolism and mitochondrial homeostasis
Sebastien Herzig & Reuben J. Shaw

Regulation of redox balance in cancer and T cells
Hyewon Kong and Navdeep S. Chandel

Metabolic rewiring in mutant Kras lung cancer
Emma M. Kerr and Carla P. Martins

Metabolism and Transcription in Cancer: Merging Two Classic Tales
Natalia Martín-Martín, Arkaitz Carracedo and Verónica Torrano

Targeting the Warburg effect for Cancer Treatment: Ketogenic Diets for Management of Glioma.
Poff A, Kourtnik A, Egan KM, Sahebjum S, D’Agostino D, Kumar NB

Cell-Autonomous Metabolic Reprogramming in Hypoxia
Luana Schito, Sergio Rey

The HIF and other quandaries in VHL disease
D Tarade and M Ohh

Lactate metabolism: historical context, prior misinterpretations, and current understanding
Brian S. Ferguson, Matthew J. Rogatzki, Matthew L. Goodwin, Daniel A. Kane, Zachary Rightmire, L. Bruce Gladden

Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
Masa Zdralevic, Ibtissam Marchiq, Monique Meyenberg Cunha de Padua, Scott Parks, and Jacques Pouysségur

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Mark A Hawk and Zachary T Schafer

The redox requirements of proliferating mammalian cells
Aaron M Hosios and Matthew G Vander Heiden

The hypoxic tumour microenvironment
Varvara Petrova, Margherita Annicchiarico-Petruzzelli, Gerry Melino & Ivano Amelio

Lipid-mediated signals that regulate mitochondrial biology
Jason R Nielson and Jared P Rutter

Spermidine in health and disease
Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer

Special Issue in Seminars in Cancer Biology
Mitochondria in Cancer
Editorial by Keshav K Singh, Josephine S. Modica-Napolitano:

Research Topic in  Front. Endocrinol
Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
Editorial:  Albert Giralt and Lluis Fajas

Comments, other

Glutamate Dehydrogenase to the Rescue
Jonathan L. Coloff

Fountain of youth of pancreatic cancer cells: the extracellular matrix
Victoire Gouirand & Sophie Vasseur

Journal Club: Mitochondria: back to the future
Navdeep S. Chandel

Profile of David M. Sabatini
Jennifer Viegas

Mutant IDH1R132H Induces Transcriptional and Epigenomic Reprogramming

R-2HG Targets FTO to Increase m6A Levels and Suppress Tumor Growth

SRPK2 Acts Downstream of MTORC1 to Promote De Novo Lipogenesis

mTORC2-Driven Lipid Synthesis Promotes Liver Tumorigenesis

FGFR3–TACC3 Activates Mitochondrial Respiration via PIN4 Phosphorylation

Glutaminolysis Drives Lung Cancer Metastasis via the PLAG1–GDH1 Axis