MetaboList – October 2022


Amino acids and one-carbon


Metabolic regulation by p53 prevents R-loop-associated genomic instability – Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01429-2

BCAT1 redox function maintains mitotic fidelity – Liliana Francois, Pavle Boskovic, Julian Knerr, Wei He, Gianluca Sigismondo, Carsten Schwan, Tushar H. More, Magdalena Schlotter, Jeroen Krijgsveld, Karsten Hiller, Robert Grosse, Peter Lichter, Bernhard Radlwimmer. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01379-1

Asparagine bioavailability regulates the translation of MYC oncogene – Sankalp Srivastava, Jie Jiang, Jagannath Misra, Gretchen Seim, Kirk A. Staschke, Minghua Zhong, Leonardo Zhou, Yu Liu, Chong Chen, Utpal Davé, Reuben Kapur, Sandeep Batra, Chi Zhang, Jiehao Zhou, Jing Fan, Ronald C. Wek and Ji Zhang. https://www.nature.com/articles/s41388-022-02474-9

Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins – Catarina Pechincha, Sven Groessl, Robert Kalis, Melanie de Almeida, Andrea Zanotti, Marten Wittmann, Martin Schneider, Rafael P. de Campos, Sarah Rieser, Marlene Brandstetter, Alexander Schleiffer, Karin Müller-Decker, Dominic Helm, Sabrina Jabs, David Haselbach, Marius K. Lemberg, Johannes Zuber, Wilhelm Palm. https://www.science.org/doi/10.1126/science.abn5637

Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1 – Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Q. Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong. https://www.jci.org/articles/view/161408


Starvation / mTOR / UPR-ISR


An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs – Cornelius Schneider, Florian Erhard, Beyenech Binotti, Alexander Buchberger, Jörg Vogel, Utz Fischer. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01317-1

A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling – Johanna B. Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan E. Eickhoff, Peter J. Murray. https://www.jbc.org/article/S0021-9258(22)01072-9/fulltext

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells – Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas and Carmen Palacios. https://www.nature.com/articles/s41419-022-05346-y

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer – Woo Kyung Lee Doolittle, Sunmi Park, Seul Gi Lee, Seonhyang Jeong, Gibbeum Lee, Dongryeol Ryu, Kristina Schoonjans, Johan Auwerx, Jandee Lee and Young Suk Jo. https://www.nature.com/articles/s41388-022-02484-7

Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention – Laura Matabishi-Bibi, Drice Challal, Mara Barucco, Domenico Libri and Anna Babour. https://www.nature.com/articles/s41467-022-34133-8

Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner – Iris Divé, Kevin Klann, Jonas B. Michaelis, Dennis Heinzen, Joachim P. Steinbach, Christian Münch and Michael W. Ronellenfitsch. https://www.nature.com/articles/s41420-022-01195-y


Glucose metabolism


ATF4-dependent fructolysis fuels growth of glioblastoma multiforme – Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You and Xinjian Li. https://www.nature.com/articles/s41467-022-33859-9

The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans – Mehul Vora, Stephanie M. Pyonteck, Tatiana Popovitchenko, Tarmie L. Matlack, Aparna Prashar, Nanci S. Kane, John Favate, Premal Shah and Christopher Rongo. https://www.nature.com/articles/s41467-022-33849-x

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma – Qi-tao Chen, Zhi-yuan Zhang, Qiao-ling Huang, Hang-zi Chen, Wen-bin Hong, Tianwei Lin, Wen-xiu Zhao, Xiao-min Wang, Cui-yu Ju, Liu-zheng Wu, Ya-ying Huang, Pei-pei Hou, Wei-jia Wang, Dawang Zhou, Xianming Deng and Qiao Wu. https://www.nature.com/articles/s42255-022-00642-5

Glucose-6-phosphate dehydrogenase exerts anti-stress effects independently of its enzymatic activity – Xiaohan Jin, Xuexue Li, Lifang Li, Benfu Zhong, Yang Hong, Jing Niu, Binghui Li. https://www.jbc.org/article/S0021-9258(22)01030-4/fulltext

Anti‐tumour effects of a macrolide analog F806 in oesophageal squamous cell carcinoma cells by targeting and promoting GLUT1 autolysosomal degradation – Xiang Li, Liyan Li, Xiaodong Wu, Bing Wen, Wan Lin, Yufei Cao, Lei Xie, Hefeng Zhang, Geng Dong, Enmin Li, Liyan Xu, Yinwei Cheng. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16545

Structural mechanism of SGLT1 inhibitors – Yange Niu, Wenhao Cui, Rui Liu, Sanshan Wang, Han Ke, Xiaoguang Lei and Lei Chen. https://www.nature.com/articles/s41467-022-33421-7


Glucose deprivation and sensing


The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK – Chen-Song Zhang, Mengqi Li, Yu Wang, Xiaoyang Li, Yue Zong, Shating Long, Mingliang Zhang, Jin-Wei Feng, Xiaoyan Wei, Yan-Hui Liu, Baoding Zhang, Jianfeng Wu, Cixiong Zhang, Wenhua Lian, Teng Ma, Xiao Tian, Qi Qu, Yaxin Yu, Jinye Xiong, Dong-Tai Liu, Zhenhua Wu, Mingxia Zhu, Changchuan Xie, Yaying Wu, Zheni Xu, Chunyan Yang, Junjie Chen, Guohong Huang, Qingxia He, Xi Huang, Lei Zhang, Xiufeng Sun, Qingfeng Liu, Abdul Ghafoor, Fu Gui, Kaili Zheng, Wen Wang, Zhi-Chao Wang, Yong Yu, Qingliang Zhao, Shu-Yong Lin, Zhi-Xin Wang, Hai-Long Piao, Xianming Deng and Sheng-Cai Lin. https://www.nature.com/articles/s42255-022-00640-7

Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation – Yang S Chen, Wanfu Hou, Sharon Tracy, Alex T Harvey, Vince Harjono, Fan Xu, James J Moresco, John R Yates III, Brian M Zid. https://elifesciences.org/articles/76965

TSC22D4 interacts with Akt1 to regulate glucose metabolism – Sevgican Demir, Gretchen Wolff, Annika Wieder, Adriano Maida, Lea Bühler, Maik Brune, Oksana Hautzinger, Annette Feuchtinger, Tanja Poth, Julia Szendroedi, Stephan Herzig, Bilgen Ekim Üstünel. https://www.science.org/doi/full/10.1126/sciadv.abo5555


Lipid metabolism


Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner – Damian E. Berardi, Althea Bock-Hughes, Alexander R. Terry, Lauren E. Drake, Grazyna Bozek, Kay F. Macleod. https://www.science.org/doi/full/10.1126/sciadv.abo2510

ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma – Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon and Amato J. Giaccia. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00290-z

Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells – Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A Frias, David A Foster. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276579

Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids – Guangyuan Zhao, Yuying Tan, Horacio Cardenas, David Vayngart, Yinu Wang, Hao Huang, Russell Keathley, Jian-Jun Wei, Christina R. Ferreira, Sandra Orsulic, Ji-Xin Cheng and Daniela Matei. https://www.pnas.org/doi/10.1073/pnas.2203480119


Cancer Immunometabolism


A Cancer Cell–Intrinsic GOT2–PPARδ Axis Suppresses Antitumor Immunity – Jaime Abrego, Hannah Sanford-Crane, Chet Oon, Xu Xiao, Courtney B. Bett, Duanchen Sun, Shanthi Nagarajan, Luis Diaz, Holly Sandborg, Sohinee Bhattacharyya, Zheng Xia, Lisa M. Coussens, Peter Tontonoz, Mara H. Sherman. https://aacrjournals.org/cancerdiscovery/article/12/10/2414/709426

Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice – Muna Al-Habsi, Kenji Chamoto, Ken Matsumoto, Norimichi Nomura, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Aprilia Maharani, Yuka Nakajima, Yibo Wu, Yayoi Nomura, Rosemary Menzies, Masaki Tajima, Koji Kitaoka, Yasuharu Haku, Sara Delghandi, Keiko Yurimoto, Fumihiko Matsuda, So Iwata, Toshihiko Ogura, Sidonia Fagarasan, Tasuku Honjo. https://www.science.org/doi/abs/10.1126/science.abj3510

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function – Ajay Kumar, Emily L. Yarosz, Anthony Andren, Li Zhang, Costas A. Lyssiotis, Cheong-Hee Chang. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01366-3

Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment – Spencer R. Rosario, Randall J. Smith Jr, Santosh K. Patnaik, Song Liu, Joseph Barbi and Sai Yendamuri. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00292-x

Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance – Qingzhu Shi, Qicong Shen, Yanfang Liu, Yang Shi, Wenwen Huang, Xi Wang, Zhiqing Li, Yangyang Chai, Hao Wang, Xiangjia Hu, Nan Li, Qian Zhang, Xuetao Cao. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00376-2

Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion – Zenan Wang, Binghao Li, Shan Li, Wenlong Lin, Zhan Wang, Shengdong Wang, Weida Chen, Wei Shi, Tao Chen, Hao Zhou, Eloy Yinwang, Wenkan Zhang, Haochen Mou, Xupeng Chai, Jiahao Zhang, Zhimin Lu and Zhaoming Ye. https://www.nature.com/articles/s41467-022-34064-4


Mitochondria / nucleotides


Two independent respiratory chains adapt OXPHOS performance to glycolytic switch – Erika Fernández-Vizarra, Sandra López-Calcerrada, Ana Sierra-Magro, Rafael Pérez-Pérez, Luke E. Formosa, Daniella H. Hock, María Illescas, Ana Peñas, Michele Brischigliaro,Shujing Ding, Ian M. Fearnley, Charalampos Tzoulis, Robert D.S. Pitceathly, Joaquín Arenas, Miguel A. Martín, David A. Stroud, Massimo Zeviani, Michael T. Ryan, Cristina Ugalde. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00395-3

HIRA loss transforms FH-deficient cells – Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R. Maher, Grant D. Stewart, Sakari Vanharanta, David J. Adams, Christian Frezza. https://www.science.org/doi/full/10.1126/sciadv.abq8297

Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation – Hae J Park, Mark A Gregory, Vadym Zaberezhnyy, Andrew Goodspeed, Craig T Jordan, Jeffrey S Kieft, James DeGregori. https://elifesciences.org/articles/79940

Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation – Kenji Miki, Mikako Yagi, Koji Yoshimoto, Dongchon Kang and Takeshi Uchiumi. https://www.nature.com/articles/s41389-022-00437-z

Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy [methotrexate] – Ahram Jang, Boryana Petrova, Taek-Chin Cheong, Miriam E. Zawadzki, Jill K. Jones, Andrew J. Culhane, Frederick B. Shipley, Roberto Chiarle, Eric T. Wong, Naama Kanarek, Maria K. Lehtinen. https://www.cell.com/neuron/fulltext/S0896-6273(22)00741-3


Miscellaneous


Scaffold-mediated switching of lymphoma metabolism in culture – Rachana Bhatt, Dashnamoorthy Ravi, Andrew M. Evens and Biju Parekkadan. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00291-y

Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition – Samuel Ogden, Kashmala Carys, Ibrahim Ahmed, Jason Bruce and Andrew D. Sharrocks. https://www.nature.com/articles/s41388-022-02465-w

Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls – Julian O. Kim, Robert Balshaw, Connel Trevena, Shantanu Banerji, Leigh Murphy, David Dawe, Lawrence Tan, Sadeesh Srinathan, Gordon Buduhan, Biniam Kidane, Gefei Qing, Michael Domaratzki and Michel Aliani. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00294-9


Reviews


The role of lipids in cancer progression and metastasis – Miguel Martin-Perez, Uxue Urdiroz-Urricelqui, Claudia Bigas, Salvador Aznar Benitah. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00447-8

Amino acid metabolism in primary bone sarcomas – Jennifer A. Jiménez, Elizabeth R. Lawlor and Costas A. Lyssiotis. https://www.frontiersin.org/articles/10.3389/fonc.2022.1001318/full

Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers – Deborah Y. Moss, Christopher McCann, Emma M. Kerr. https://www.science.org/doi/abs/10.1126/scisignal.abj3490

GOT2 consider the tumor microenvironment – Brian T. Do, Matthew G. Vander Heiden. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00195-9

Targeting PDAC metabolism: Environment determines what has GOT2 give – Oliver J. Newsom, Lucas B. Sullivan

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00451-X

Nutrient availability as an arbiter of cell size – Douglas R. Kellogg, Petra Anne Levin. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00147-7

Non-canonical mTORC1 signaling at the lysosome – Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00117-9

Principles and functions of metabolic compartmentalization – Liron Bar-Peled and Nora Kory. https://www.nature.com/articles/s42255-022-00645-2

Metabolic guidance and stress in tumors modulate antigen-presenting cells – Jaeoh Park, Limei Wang and Ping-Chih Ho. https://www.nature.com/articles/s41389-022-00438-y

Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer – Léa Montégut, Rafael de Cabo, Laurence Zitvogel, Guido Kroemer. https://aacrjournals.org/cancerdiscovery/article-abstract/12/10/2258/709430


Comments


Nuclear TCA cycle reactions – Melina Casadio. https://www.nature.com/articles/s41556-022-01006-7

Starving cancer into submission by activating BAT – Mohammed K. Hankir, Annett Hoffmann, Florian Seyfried. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00399-0

Gliomas lean on pyrimidines – Joseph Willson. https://www.nature.com/articles/s41568-022-00515-9

Liver cancer metabolism: a hexokinase from the stars – Aveline Filliol and Robert F. Schwabe. https://www.nature.com/articles/s42255-022-00659-w

Glutamine, MTOR and autophagy: a multiconnection relationship – Clément Bodineau, Mercedes Tomé, Piedad del Socorro Murdoch and Raúl V. Durán. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2062875

Cold exposure as anti-cancer therapy – Mariia Yuneva. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00437-8

Transient Systemic Autophagy Ablation Irreversibly Inhibits Lung Tumor Cell Metabolism and Promotes T-Cell Mediated Tumor Killing – Kyle Nunn and Jessie Yanxiang Guo. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2141534

MetaboList – September 2022


Lipid and acetate metabolism


Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity – Marta Barradas, Adrián Plaza, Gonzalo Colmenarejo, Iolanda Lázaro, Luis Filipe Costa-Machado, Roberto Martín-Hernández, Victor Micó, José Luis López-Aceituno, Jesús Herranz, Cristina Pantoja, Hector Tejero, Alberto Diaz-Ruiz, Fatima Al-Shahrour, Lidia Daimiel, Viviana Loria-Kohen, Ana Ramirez de Molina, Alejo Efeyan, Manuel Serrano, Oscar J. Pozo, Aleix Sala-Vila and Pablo J. Fernandez-Marcos. https://www.nature.com/articles/s41467-022-33352-3

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells – Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia. https://elifesciences.org/articles/75908

KIF11 manipulates SREBP2‐dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma – Xiang Gu, Qunshan Zhu, Guangyu Tian, Wenbo Song, Tao Wang, Ali Wang, Xiaojun Chen, Songbing Qin. https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.4683

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer – Xiaopeng Xiong, Sumati Hasani, Lyndsay E. A. Young, Dylan R. Rivas, Ashley T. Skaggs, Rebecca Martinez, Chi Wang, Heidi L. Weiss, Matthew S. Gentry, Ramon C. Sun and Tianyan Gao. https://www.nature.com/articles/s41418-022-00974-5


Nucleotides


A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma – Sharmistha Pal, Jakub P. Kaplan, Huy Nguyen, Sylwia A. Stopka, Milan R. Savani, Michael S. Regan, Quang-De Nguyen, Kristen L. Jones, Lisa A. Moreau, Jingyu Peng, Marina G. Dipiazza, Andrew J. Perciaccante, Xiaoting Zhu, Bradley R. Hunsel, Kevin X. Liu, Sanda Alexandrescu, Rachid Drissi, Mariella G. Filbin, Samuel K. McBrayer, Nathalie Y.R. Agar, Dipanjan Chowdhury, Daphne A. Haas-Kogan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00325-7

Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer – Abhinav Achreja, Tao Yu, Anjali Mittal, Srinadh Choppara, Olamide Animasahun, Minal Nenwani, Fulei Wuchu, Noah Meurs, Aradhana Mohan, Jin Heon Jeon, Itisam Sarangi, Anusha Jayaraman, Sarah Owen, Reva Kulkarni, Michele Cusato, Frank Weinberg, Hye Kyong Kweon, Chitra Subramanian, Max S. Wicha, Sofia D. Merajver, Sunitha Nagrath, Kathleen R. Cho, Analisa DiFeo, Xiongbin Lu and Deepak Nagrath. https://www.nature.com/articles/s42255-022-00636-


IDH


Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function – Giulia Notarangelo, Jessica B. Spinelli, Elizabeth M. Perez, Gregory J. Baker, Kiran Kurmi, Ilaria Elia, Sylwia A. Stopka, Gerard Baquer, Jia-Ren Lin, Alexandra J. Golby, Shakchhi Joshi, Heide F. Baron, Jefte M. Drijvers, Peter Georgiev, Alison E. Ringel, Elma Zaganjor, Samuel K. McBrayer, Peter K. Sorger, Arlene H. Sharpe, Kai W. Wucherpfennig, Sandro Santagata, Nathalie Y. R. Agar, Mario L. Suvà, Marcia C. Haigis. https://www.science.org/doi/abs/10.1126/science.abj5104

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma – Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, Joyce H. Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy B. Cameron, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin Jr., Samuel K. McBrayer. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00324-5


Cancer Immunometabolism


Carbon source availability drives nutrient utilization in CD8+ T cells – Irem Kaymak, Katarzyna M. Luda, Lauren R. Duimstra, Eric H. Ma, Joseph Longo, Michael S. Dahabieh, Brandon Faubert, Brandon M. Oswald, McLane J. Watson, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Shelby E. Compton, Zhen Fu, Ralph J. DeBerardinis, Kelsey S. Williams, Ryan D. Sheldon, Russell G. Jones. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00311-4

Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity – Qiang Feng, Zhida Liu, Xuexin Yu, Tongyi Huang, Jiahui Chen, Jian Wang, Jonathan Wilhelm, Suxin Li, Jiwon Song, Wei Li, Zhichen Sun, Baran D. Sumer, Bo Li, Yang-Xin Fu and Jinming Gao. https://www.nature.com/articles/s41467-022-32521-8

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis – Ping Yang, Hong Qin, Yiyu Li, Anhua Xiao, Enze Zheng, Han Zeng, Chunxiao Su, Xiaoqing Luo, Qiannan Lu, Meng Liao, Lei Zhao, Li Wei, Zac Varghese, John F. Moorhead, Yaxi Chen and Xiong Z. Ruan. https://www.nature.com/articles/s41467-022-33349-y

USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer – Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song and Wenting Liao. https://www.nature.com/articles/s41467-022-33285-x

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα – Dong Guo, Yingying Tong, Xiaoming Jiang, Ying Meng, Hongfei Jiang, Linyong Du, Qingang Wu, Shan Li, Shudi Luo, Min Li, Liwei Xiao, Haiyan He, Xuxiao He, Qiujing Yu, Jing Fang, Zhimin Lu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00345-X


Mitochondria


Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway – Peng Wei, Alex J. Bott, Ahmad A. Cluntun, Jeffrey T. Morgan, Corey N. Cunningham, John C. Schell, Yeyun Ouyang, Scott B. Ficarro, Jarrod A. Marto, Nika N. Danial, Ralph J. DeBerardinis, Jared Rutter. https://www.science.org/doi/full/10.1126/sciadv.abq0117

Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions – Pu Zhang, Lindsey T. Brinton, Mehdi Gharghabi, Steven Sher, Katie Williams, Matthew Cannon, Janek S. Walker, Daniel Canfield, Larry Beaver, Casey B. Cempre, Hannah Phillips, Xuyong Chen, Pearlly Yan, Amy Lehman, Peggy Scherle, Min Wang, Kris Vaddi, Robert Baiocchi, Ruoning Wang, Deepa Sampath, Lapo Alinari, James S. Blachly, Rosa Lapalombella. https://www.science.org/doi/full/10.1126/sciadv.abp9005?et_rid=33946976

Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells – James T. Hagen, McLane M. Montgomery, Ericka M. Biagioni, Polina Krassovskaia, Filip Jevtovic, Daniel Shookster, Uma Sharma, Kang Tung, Nickolas T. Broskey, Linda May, Hu Huang, Jeffrey J. Brault, P. Darrell Neufer, Myles C. Cabot, Kelsey H. Fisher-Wellman. https://www.sciencedirect.com/science/article/abs/pii/S0005272822003851


Starvation


Sensitisation of cancer cells to radiotherapy by serine and glycine starvation – Mattia Falcone, Alejandro Huerta Uribe, Vasileios Papalazarou, Alice C. Newman, Dimitris Athineos, Katrina Stevenson, Charles-Etienne Gabriel Sauvé, Yajing Gao, Jin K. Kim, Michael Del Latto, Maria Kierstead, Chao Wu, J. Joshua Smith, Paul B. Romesser, Anthony J. Chalmers, Karen Blyth and Oliver D. K. Maddocks. https://www.nature.com/articles/s41416-022-01965-6

Mitochondrial and metabolic remodelling in human skin fibroblasts in response to glucose availability – Sónia A. Pinho, Cláudio F. Costa, Cláudia M. Deus, Sonia L. C. Pinho, Inês Miranda-Santos, Gonçalo Afonso, Olivia Bagshaw, Jeffrey A. Stuart, Paulo J. Oliveira, Teresa Cunha-Oliveira. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16413

cAMP-Protein Kinase A and Stress-Activated MAP Kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation – Armando Jesús Pérez-Díaz, Beatriz Vázquez-Marín, Jero Vicente-Soler, Francisco Prieto-Ruiz, Teresa Soto, Alejandro Franco, José Cansado and Marisa Madrid. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2125204

AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation [In collection: Metabolism] – Kuan-Jung Chen, Jia-Wei Hsu, Fang-Jen S. Lee. https://journals.biologists.com/jcs/article/135/18/jcs259609/276628


mTOR


A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids – Peter Gollwitzer, Nina Grützmacher, Sabine Wilhelm, Daniel Kümmel and Constantinos Demetriades. https://www.nature.com/articles/s41556-022-00976-y

Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition – Gianluca Figlia, Sandra Müller, Anna M. Hagenston, Susanne Kleber, Mykola Roiuk, Jan-Philipp Quast, Nora ten Bosch, Damian Carvajal Ibañez, Daniela Mauceri, Ana Martin-Villalba and Aurelio A. Teleman. https://www.nature.com/articles/s41556-022-00977-x

Brain-restricted mTOR inhibition with binary pharmacology – Ziyang Zhang, Qiwen Fan, Xujun Luo, Kevin Lou, William A. Weiss and Kevan M. Shokat. https://www.nature.com/articles/s41586-022-05213-y

Invading Bacterial Pathogens Activate Transcription Factor EB in Epithelial Cells through the Amino Acid Starvation Pathway of mTORC1 Inhibition – Liliane Cabral-Fernandes, Shawn Goyal, Armin Farahvash, Jessica Tsalikis, Dana J. Philpott, Stephen E. Girardin. https://journals.asm.org/doi/abs/10.1128/mcb.00241-22

Tissue-restricted inhibition of mTOR using chemical genetics – Douglas R. Wassarman, Kondalarao Bankapalli, Leo J. Pallanck, and Kevan M. Shokat. https://www.pnas.org/doi/10.1073/pnas.2204083119

Glucose-driven TOR–FIE–PRC2 signalling controls plant development – Ruiqiang Ye, Meiyue Wang, Hao Du, Shweta Chhajed, Jin Koh, Kun-hsiang Liu, Jinwoo Shin, Yue Wu, Lin Shi, Lin Xu, Sixue Chen, Yijing Zhang and Jen Sheen. https://www.nature.com/articles/s41586-022-05171-5

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma – Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas and Ryan M. Young. https://www.nature.com/articles/s41467-022-33142-x


Hypoxia


FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A – Xiaohai Wang, Lourdes Brea, Xiaodong Lu, Galina Gritsina, Su H. Park, Wanqing Xie, Jonathan C. Zhao and Jindan Yu. https://www.nature.com/articles/s41388-022-02423-6

Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation – Chloe-Anne Martinez, Yannasittha Jiramongkol, Neha Bal, Imala Alwis, Polina E. Nedoboy, Melissa MJ. Farnham, Mark D. White, Peter A. Cistulli, Kristina M. Cook. https://www.jbc.org/article/S0021-9258(22)00979-6


Reviews


Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer – Jacob M. Winter, Tarun Yadav, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00708-0

Glutaminase Inhibitors—Do They Have a Role in the Treatment of Metastatic Clear-Cell Renal Cell Carcinoma? – Janet E. Brown. https://jamanetwork.com/journals/jamaoncology/article-abstract/2795983

Metabolic reprogramming: a bridge between aging and tumorigenesis – Stanislav Drapela, Didem Ilter, Ana P. Gomes. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13261

Genetic approaches to understand cellular responses to oxygen availability – Brian M. Ortmann, James A. Nathan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16072

Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis – Valeria Manuelli, Chiara Pecorari, Giuseppe Filomeni, Ester Zito. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16110

Metabolic Reprogramming in Hematologic Malignancies: Advances and Clinical Perspectives – Zhuoya Yu, Xiangxiang Zhou, Xin Wang. https://aacrjournals.org/cancerres/article/82/17/2955/708282

The Central Role of mTORC1 in Amino Acid Sensing – Shusheng Yue, Guanya Li, Shanping He, Tingting Li. https://aacrjournals.org/cancerres/article-abstract/82/17/2964/708284

AMPK: An odyssey of a metabolic regulator, a tumor suppressor, and now a contextual oncogene – Vasudevarao Penugurti, Yasaswi Gayatri Mishra, Bramanandam Manavathi. https://www.sciencedirect.com/science/article/abs/pii/S0304419X2200110X


Comments


Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer – Vaibhav Jain, Ravi K. Amaravadi. https://aacrjournals.org/cancerdiscovery/article-abstract/12/9/2023/708772

Plasma L-Arginine Predicts Clinical Response to Immune Checkpoint Inhibitors – https://aacrjournals.org/cancerdiscovery/article-abstract/12/9/OF6/708788

Metabolite-driven antitumor immunity [D-2HG] – https://www.science.org/doi/10.1126/science.ade3697


Glucose metabolism


Glycolytic oscillations in HeLa cervical cancer cell spheroids – Takashi Amemiya, Kenichi Shibata, Junpei Takahashi, Masatoshi Watanabe, Satoshi Nakata, Kazuyuki Nakamura, Tomohiko Yamaguchi. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16454

ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3 – Mengnan Hu, Ruoxuan Bao, Miao Lin, Xiao-Ran Han, Ying-Jie Ai, Yun Gao, Kun-Liang Guan, Yue Xiong and Hai-Xin Yuan. https://www.nature.com/articles/s41388-022-02453-0

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma – Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnölzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt and Violaine Goidts. https://www.nature.com/articles/s41389-022-00433-3

Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression – Ya Jiang, Ting Wang, Dandan Sheng, Chaoqiang Han, Tian Xu, Peng Zhang, Weiyi You, Weiwei Fan, Zhiyong Zhang, Tengchuan Jin, Xiaotao Duan, Xiao Yuan, Xing Liu, Kaiguang Zhang, Ke Ruan, Jue Shi, Jing Guo, Aoxing Cheng, Zhenye Yang. https://www.jbc.org/article/S0021-9258(22)01005-5/fulltext


Amino acid metabolism


GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma – Sawako Suzuki, Divya Venkatesh, Hiroaki Kanda, Akitoshi Nakayama, Hiroyuki Hosokawa, Eunyoung Lee, Takashi Miki, Brent R. Stockwell, Koutaro Yokote, Tomoaki Tanaka, Carol Prives. https://aacrjournals.org/cancerres/article-abstract/82/18/3209/709027

GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors – Yunzheng Li, Binghua Li, Yanchao Xu, Liyuan Qian, Tiancheng Xu, Gang Meng, Huan Li, Ye Wang, Laizhu Zhang, Xiang Jiang, Qi Liu, Yuanyuan Xie, Chunxiao Cheng, Beicheng Sun, Decai Yu. https://aacrjournals.org/cancerres/article-abstract/82/18/3223/709031

NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling – Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson and Ze’ev A. Ronai. https://www.nature.com/articles/s41556-022-00985-x

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis – Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Robero Pili Is a corresponding author, Ronald C Wek Is a corresponding author, Kirk A Staschke. https://elifesciences.org/articles/81083

Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma. The CANTATA Randomized Clinical Trial – Nizar M. Tannir, Neeraj Agarwal, Camillo Porta, Nicola J. Lawrence, Robert Motzer, Bradley McGregor, Richard J. Lee, Rohit K. Jain, Nancy Davis, Leonard J. Appleman, Oscar Goodman Jr, Walter M. Stadler, Sunil Gandhi, Daniel M. Geynisman, Roberto Iacovelli, Begoña Mellado, Juan Manuel Sepúlveda Sánchez, Robert Figlin, Thomas Powles, Lalith Akella, Keith Orford, Bernard Escudier. https://jamanetwork.com/journals/jamaoncology/article-abstract/2795979

MetaboList – August 2022


Glucose/Warburg metabolism


Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells – Yahui Wang, Ethan Stancliffe, Ronald Fowle-Grider, Rencheng Wang, Cheng Wang, Michaela Schwaiger-Haber, Leah P. Shriver, Gary J. Patti. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00703-1 Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis – Dan He, Huijin Feng, Belen Sundberg, Jiaxing Yang, Justin Powers, Alec H. Christian, John E. Wilkinson, Cian Monnin, Daina Avizonis, Craig J. Thomas, Richard A. Friedman, Michael D. Kluger, Michael A. Hollingsworth, Paul M. Grandgenett, Kelsey A. Klute, F. Dean Toste, Christopher J. Chang, Iok In Christine Chio. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00541-X RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1 – Yifei Pei, Shuning Lv, Yong Shi, Jingwen Jia, Mengru Ma, Hailong Han, Rongying Zhang, Jieqiong Tan and Xinjun Zhang. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2114271 An Integrated Proteomic and Glycoproteomic Investigation Reveals Alterations in the N-Glycoproteomic Network Induced by 2-Deoxy-D-Glucose in Colorectal Cancer Cells – Cheng Ma, Hong-Yuan Tsai, Qi Zhang, Lakmini Senavirathna, Lian Li, Lih-Shen Chin, Ru Chen and Sheng Pan. https://www.mdpi.com/1422-0067/23/15/8251/htm#app1-ijms-23-08251 PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway – Min Liu, Runmei Li, Min Wang, Ting Liu, Qiuru Zhou, Dong Zhang, Jian Wang, Meng Shen, Xiubao Ren, Qian Sun. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13259 Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate – John N. Koberstein, Melissa L. Stewart, Chadwick B. Smith, Andrei I. Tarasov, Frances M. Ashcroft, Philip J. S. Stork and Richard H. Goodman. https://www.pnas.org/doi/10.1073/pnas.2204407119

Lipid/NADPH sensing and metabolism


Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1 – Hijai R. Shin, Y. Rose Citron, Lei Wang, Laura Tribouillard, Claire S. Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson4, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, Rushika M. Perera, Eunyong Park, Douglas F. Covey, Mathieu Laplante, Alex S. Evers, Roberto Zoncu. https://www.science.org/doi/10.1126/science.abg6621 Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma – Fangzhou Liu, Tian Tian, Zhen Zhang, Shanshan Xie, Jiecheng Yang, Linyu Zhu, Wen Wang, Chengyu Shi, Lingjie Sang, Kaiqiang Guo, Zuozhen Yang, Lei Qu, Xiangrui Liu, Jian Liu, Qingfeng Yan, Huai-qiang Ju, Wenqi Wang, Hai-long Piao, Jianzhong Shao, Tianhua Zhou and Aifu Lin. https://www.nature.com/articles/s42255-022-00616-7 Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells – Yuying Tan, Junjie Li, Guangyuan Zhao, Kai-Chih Huang, Horacio Cardenas, Yinu Wang, Daniela Matei and Ji-Xin Cheng. https://www.nature.com/articles/s41467-022-32101-w The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis – Kha The Nguyen, Sang-Hyeon Mun, Jihye Yang, Jongeun Lee, Ok-Hee Seok, Eunjeong Kim, Dasom Kim, So Young An, Dong-Young Seo, Jeong-Yong Suh, Yoontae Lee and Cheol-Sang Hwang. https://www.nature.com/articles/s41556-022-00973-1

Nutrient sensing/mTOR/AMPK


Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly – Edoardo Ratto, S. Roy Chowdhury, Nora S. Siefert, Martin Schneider, Marten Wittmann, Dominic Helm and Wilhelm Palm. https://www.nature.com/articles/s41467-022-32515-6 Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment – Yan Tang, David J. Kwiatkowski and Elizabeth P. Henske. https://www.nature.com/articles/s41467-022-32673-7 The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations – Tianzhuo Wang, Huiying Guo, Qianchen Li, Weijie Wu, Miao Yu, Lei Zhang, Cuicui Li, Jiagui Song, Zhenbin Wang, Jing Zhang, Yan Tang, Lei Kang, Hongquan Zhang, Jun Zhan https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01074-9 Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells – Younghwan Lee, Yoko Itahana, Choon Chen Ong, Koji Itahana. https://journals.biologists.com/jcs/article-abstract/135/15/jcs259090/276257 Manganese is a physiologically relevant TORC1 activator in yeast and mammals – Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, Marie-Pierre Péli-Gulli, Elisabet Fernández-García, Mercedes Tomé, Néstor García-Rodríguez, Raúl V Durán, Claudio De Virgilio Is a corresponding author, Ralf Erik Wellinger. https://elifesciences.org/articles/80497 DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting – Christopher J. Yuskaitis, Jinita B. Modasia, Sandra Schrötter, Leigh-Ana Rossitto, Karenna J. Groff, Christopher Morici, Divakar S. Mithal, Ram P. Chakrabarty, Navdeep S. Chandel, Brendan D. Manning, Mustafa Sahin. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01098-1 PTEN inhibits AMPK to control collective migration – Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense and Sandrine Etienne-Manneville. https://www.nature.com/articles/s41467-022-31842-y

Nucleotide metabolism and sensing


Nucleotide imbalance decouples cell growth from cell proliferation – Frances F. Diehl, Teemu P. Miettinen, Ryan Elbashir, Christopher S. Nabel, Alicia M. Darnell, Brian T. Do, Scott R. Manalis, Caroline A. Lewis and Matthew G. Vander Heiden. https://www.nature.com/articles/s41556-022-00965-1 The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis – Eunus S. Ali, Anna Lipońska, Brendan P. O’Hara, David R. Amici, Michael D. Torno, Peng Gao, John M. Asara, Mee-Ngan F. Yap, Marc L. Mendillo, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00544-5 SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis – Erica Pranzini, Elisa Pardella, Livio Muccillo, Angela Leo, Ilaria Nesi, Alice Santi, Matteo Parri, Tong Zhang, Alejandro Huerta Uribe, Tiziano Lottini, Lina Sabatino, Anna Caselli, Annarosa Arcangeli, Giovanni Raugei, Vittorio Colantuoni, Paolo Cirri, Paola Chiarugi, Oliver D.K. Maddocks, Paolo Paoli, Maria Letizia Taddei. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01050-6 Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth – Meng Yuan, Bo Tu, Hengchao Li, Huanhuan Pang, Nan Zhang, Minghe Fan, Jingru Bai, Wei Wang, Zhaoqi Shu, Christopher C. DuFort, Sihan Huo, Jie Zhai, Ke Yao, Lina Wang, Haoqiang Ying, Wei-Guo Zhu, Deliang Fu, Zeping Hu and Ying Zhao. https://www.nature.com/articles/s43018-022-00426-

Amino acid metabolism


Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers – Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniela Annibali and Frédéric Amant. https://www.nature.com/articles/s41467-022-32272-6 Glutamine addiction promotes glucose oxidation in triple-negative breast cancer – Lake-Ee Quek, Michelle van Geldermalsen, Yi Fang Guan, Kanu Wahi, Chelsea Mayoh, Seher Balaban, Angel Pang, Qian Wang, Mark J. Cowley, Kristin K. Brown, Nigel Turner, Andrew J. Hoy and Jeff Holst. https://www.nature.com/articles/s41388-022-02408-5 Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context – Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis. https://elifesciences.org/articles/73245 I also recommend the selection: “Glutamine cancer metabolism” by Sreeparna Banerjee – Sign up at http://biomed.news/reports

Mitochondria / heme / hypoxia


Operation of a TCA cycle subnetwork in the mammalian nucleus – Eleni Kafkia, Amparo Andres-Pons, Kerstin Ganter, Markus Seiler, Tom S. Smith, Anna Andrejeva, Paula Jouhten, Filipa Pereira, Catarina Franco, Anna Kuroshchenkova, Sergio Leone, Ritwick Sawarkar, Rebecca Boston, James Thaventhiran, Judith B. Zaugg1, Kathryn S. Lilley, Christophe Lancrin, Martin Beck, Kiran Raosaheb Patil. https://www.science.org/doi/10.1126/sciadv.abq5206 In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors – Panayotis Pachnis, Zheng Wu, Brandon Faubert, Alpaslan Tasdogan, Wen Gu, Spencer Shelton, Ashley Solmonson, Aparna D. Rao, Akash K. Kaushik,  Thomas J. Rogers, Jessalyn M. Ubellacker, Collette A. LaVigne, Chendong Yang1, Bookyung Ko1, Vijayashree Ramesh, Jessica Sudderth, Lauren G. Zacharias,  Misty S. Martin-Sandoval1, Duyen Do1, Thomas P. Mathews1, Zhiyu Zhao, Prashant Mishra, Sean J. Morrison, Ralph J. DeBerardinis. https://www.science.org/doi/10.1126/sciadv.abn9550 Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction – Isabelle Adant, Matthew Bird, Bram Decru, Petra Windmolders, Marie Wallays, Peter de Witte, Daisy Rymen, Peter Witters, Pieter Vermeersch, David Cassiman, Bart Ghesquière. https://www.sciencedirect.com/science/article/pii/S2212877822001065 Glutamine metabolism mediates sensitivity to respiratory complex II inhibition in acute myeloid leukemia – Alessia Roma,  Matthew Tcheng; Nawaz Ahmed; Sarah Walker; Preethi Jayanth; Mark D. Minden; Kristin Hope; Praveen P. Nekkar Rao; Jessica Luc; Andrew C. Doxey; Julie A. Reisz; Rachel Culp-Hill; Angelo D’Alessandro; Paul A. Spagnuolo. https://aacrjournals.org/mcr/article-abstract/doi/10.1158/1541-7786.MCR-21-1032/708293 Hypoxia‐induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R – Seung Hee Seo, Soo-Yeon Hwang, Seohui Hwang, Sunjung Han, Hyojin Park, Yun-Sil Lee, Seung Bae Rho, Youngjoo Kwon https://www.embopress.org/doi/full/10.15252/embr.202152977 Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability – Gokhan Unlu, Benjamin Prizer, Ranya Erdal, Hsi-Wen Yeh, Erol C. Bayraktar, Kıvanç Birsoy. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00491-9 I also recommend the selection: “Mitochondrial metabolism in cancer” by Christian Frezza. Sign up at http://biomed.news/reports

Starvation/the UPR/celll death


Sublethal cytochrome c release generates drug-tolerant persister cells – Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W.G. Tait, Colin R. Goding, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(22)00978-3 Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells – Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas and Jose C. Perales. https://www.nature.com/articles/s41419-022-05177-x GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment – Rindert Missiaen, Nicole M. Anderson, Laura C. Kim, Bailey Nance, Michelle Burrows, Nicolas Skuli, Madeleine Carens, Romain Riscal, An Steensels, Fuming Li, M. Celeste Simon. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00230-3 Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector – Ruizhi Li, Kristin F. Wilson and Richard A. Cerione. https://www.nature.com/articles/s41420-022-01156-5 Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling under leucine deprivation – Junki Yamamura, Sihui Ma, Huijuan Jia and Hisanori Kato. https://www.frontiersin.org/articles/10.3389/fnut.2022.965771/full The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages – Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R. Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E. Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V. Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L. Oliveira, Marco Constante, Manuela M. Santos, Carlos R. Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho and Soroush Tahmasebi. https://www.pnas.org/doi/10.1073/pnas.2121251119 Supramolecular assembly of GSK3α as a cellular response to amino acid starvation – Laura Hinze, Sabine Schreek, Andre Zeug, Nurul Khalida Ibrahim, Beate Fehlhaber, Lorent Loxha, Buesra Cinar, Evgeni Ponimaskin, James Degar, Connor McGuckin, Gabriela Chiosis, Cornelia Eckert, Gunnar Cario, Beat Bornhauser, Jean-Pierre Bourquin, Martin Stanulla, Alejandro Gutierrez. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00492-0 FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma – Junjun Li, Yongchang Zhang, Li Wang, Min Li, Jianbo Yang, Pan Chen, Jie Zhu, Xiayu Li, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, James B. McCarthy, Bo Xiang and Mei Yi. https://www.nature.com/articles/s41419-022-05150-8 I also recommend the selection: “Unfolded protein response” by Susan Logue. Sign up at http://biomed.news/reports

Cancer Immunometabolism


Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells – Ilaria Elia, Jared H. Rowe, Sheila Johnson, Shakchhi Joshi, Giulia Notarangelo, Kiran Kurmi, Sarah Weiss, Gordon J. Freeman, Arlene H. Sharpe, Marcia C. Haigis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00228-5 TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells – Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00538-X Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects [in mice] – Salvatore Cortellino, Alessandro Raveane, Claudia Chiodoni, Gloria Delfanti, Federica Pisati, Vanessa Spagnolo, Euplio Visco, Giuseppe Fragale, Federica Ferrante, Serena Magni, Fabio Iannelli, Federica Zanardi, Giulia Casorati, Francesco Bertolini, Paolo Dellabona, Mario P. Colombo, Claudio Tripodo, Valter D. Longo. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01074-9 Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response – Kazi Mokim Ahmed, Ratna Veeramachaneni, Defeng Deng, Nagireddy Putluri, Vasanta Putluri, Maria F Cardenas, David A Wheeler, William K Decker, Andy I Frederick, Sawad Kazi, Andrew G Sikora, Vlad C Sandulache and Mitchell J Frederick. https://jitc.bmj.com/content/10/8/e004752 I also recommend the selection: “Immunometabolism of infection, cancer and immune-mediated disease” by Dylan Ryan. Sign up at http://biomed.news/reports

IDH


Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells – Emily Gruber, Joan So, Alexander C. Lewis, Rheana Franich, Rachel Cole, Luciano G. Martelotto, Amy J. Rogers, Eva Vidacs, Peter Fraser, Kym Stanley, Lisa Jones, Anna Trigos, Niko Thio, Jason Li, Brandon Nicolay, Scott Daigle, Adriana E. Tron, Marc L. Hyer, Jake Shortt, Ricky W. Johnstone, Lev M. Kats. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00995-0 Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors – Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud and Christopher J. Schofield. https://www.nature.com/articles/s41467-022-32436-4
Miscellaneous
MYC sensitises cells to apoptosis by driving energetic demand – Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen and Andrew J. Finch Show fewer authors. https://www.nature.com/articles/s41467-022-32368-z Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures – Fariba Roshanzamir, Jonathan L. Robinson, Daniel Cook, Mohammad Hossein Karimi-Jafari and Jens Nielsen. https://www.pnas.org/doi/10.1073/pnas.2205456119 Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer – Rui An, Haitao Yu, Yanzhong Wang, Jie Lu, Yuzhen Gao, Xinyou Xie and Jun Zhang. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00289-6 Other recommended reports at http://biomed.news/reportsMetabolism and paracrine crosstalk between cancer and the organism” by Cristina Muñoz Pinedo “Metabolism of non-small cell lung carcinoma“, by the Muñoz Pinedo/Nadal lab “Metabolic-dependent epigenetic reprogramming in differentiation and disease“, by Alessandro Carrer.

Reviews


A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements – Ajit S. Divakaruni and Martin Jastroch. https://www.nature.com/articles/s42255-022-00619-4 Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance – Sophie Vasseur and Fabienne Guillaumond. https://www.nature.com/articles/s41389-022-00420-8 Regulation of gene expression by glycolytic and gluconeogenic enzymes – Xueli Bian, Hongfei Jiang, Ying Meng, Ying-ping Li, Jing Fang, Zhimin Lu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00036- Transsulfuration, minor player or crucial for cysteine homeostasis in cancer – Hai-Feng Zhang, Ramon I. Klein Geltink, Seth J. Parker, Poul H. Sorensen. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(22)00036-8 Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia – Benzheng Jiao, Shanshan Liu, Hongguang Zhao, Yuying Zhuang, Shumei Ma, Chenghe Lin, Jifan Hu and Xiaodong Liu. https://www.nature.com/articles/s41419-022-05114-y

Comments/other


The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation – Hyllana C.D. Medeiros, Sophia Y. Lunt. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00757-2 PYGBacking on glycogen metabolism to fuel early memory T cell recall responses – Joseph Longo, McLane J. Watson, Matthew J. Vos, Kelsey S. Williams, Russell G. Jones. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00712-2 SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate – Jessica C. Koe, Keeley G. Hewton, Seth J. Parker. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00763-8 Leucine Dieting Inhibits Immunosuppressive B Cells in Colorectal Cancer. https://aacrjournals.org/cancerdiscovery/article-abstract/12/8/OF15/707242 NUFIP1+ stroma keeps PDAC fed – Holly Sandborg and Mara H. Sherman. https://www.nature.com/articles/s43018-022-00421-x Conference: EACR “Cancer Metabolism“. Bilbao, Spain : 11 – 13 October 2022. Organizers: Arkaitz Carracedo, Christian Frezza, Sarah-Maria Fendt, Sara Zanivan. https://www.eacr.org/conference/cancermetabolism2022/scientific-programme Conference: “Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer“. Oct. 24/25th. Organizers: Payam Gammage, Stephen Tait , Tom MacVicar. Glasgow, UK. https://www.beatson.gla.ac.uk/Beatson-Workshop-October-2022/programme.html

MetaboList – July 2022


Nutrient sensing/starvation


Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila – Xin Gu, Patrick Jouandin, Pranav V. Lalgudi, Rich Binari, Max L. Valenstein, Michael A. Reid, Annamarie E. Allen, Nolan Kamitaki, Jason W. Locasale, Norbert Perrimon and David M. Sabatini. https://www.nature.com/articles/s41586-022-04960-2

Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila – Hina Kosakamoto, Naoki Okamoto, Hide Aikawa, Yuki Sugiura, Makoto Suematsu, Ryusuke Niwa, Masayuki Miura and Fumiaki Obata. https://www.nature.com/articles/s42255-022-00608-7

Structure of the nutrient-sensing hub GATOR2 – Max L. Valenstein, Kacper B. Rogala, Pranav V. Lalgudi, Edward J. Brignole, Xin Gu, Robert A. Saxton, Lynne Chantranupong, Jonas Kolibius, Jan-Philipp Quast and David M. Sabatini. https://www.nature.com/articles/s41586-022-04939-z

DRAM‐4 and DRAM‐5 are compensatory regulators of autophagy and cell survival in nutrient‐deprived conditions – Valentin J. A. Barthet, Michaela Mrschtik, Elzbieta Kania, David G. McEwan, Dan Croft, James O’Prey, Jaclyn S. Long, Kevin M. Ryan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16365

Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter – Danielle L. Schmitt, Stephanie D. Curtis, Anne C. Lyons, Jin-fan Zhang, Mingyuan Chen, Catherine Y. He, Sohum Mehta, Reuben J. Shaw and Jin Zhang. https://www.nature.com/articles/s41467-022-31190-x


Starvation – UPR


The amino acid sensor GCN2 suppresses Terminal Oligopyrimidine (TOP) mRNA translation via La-related Protein 1 (LARP1) – Zeenat Farooq, Fedho Kusuma, Phillip Burke, Catherine R. Dufour, Duckgue Lee, Negar Tabatabaei, Phoenix Toboz, Ernest Radovani, Jack Greenblatt, Jalees Rehman, Jacob Class, Arkady Khoutorsky, Bruno D. Fonseca, Justin M. Richner, Eloi Mercier, Guillaume Bourque, Vincent Giguère, Arvind R. Subramaniam, Jaeseok Han, Soroush Tahmasebi. https://www.jbc.org/article/S0021-9258(22)00719-0/fulltext

Activation of the canonical ER Stress IRE1-XBP1 Pathway by Insulin Regulates Glucose and Lipid Metabolism – Jinghua Peng, Caolitao Qin, Balamurugan Ramatchandirin, Alexia Pearah, Shaodong Guo, Mehboob Hussain, Liqing Yu, Fredric E. Wondisford, Ling He. https://www.jbc.org/article/S0021-9258(22)00725-6

FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity – Hilde Herrema, Dongxian Guan, Jae Won Choi, Xudong Feng, Mario Andres Salazar Hernandez, Farhana Faruk, Thomas Auen, Eliza Boudett, Rongya Tao, Hyonho Chun, Umut Ozcan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00227-3

Activated amino acid response pathway generates apatinib resistance by reprograming glutamine metabolism in non-small-cell lung cancer – Xiaoshu Zhou, Rui Zhou, Xinrui Rao, Jiaxin Hong, Qianwen Li, Xiaohua Jie, Jian Wang, Yingzhuo Xu, Kuikui Zhu, Zhenyu Li and Gang Wu. https://www.nature.com/articles/s41419-022-05079-y


mTOR


Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate – Swantje Liedmann, Xueyan Liu, Clifford S. Guy, Jeremy Chase Crawford, Diego A. Rodriguez, Duygu Kuzuoğlu-Öztürk, Ao Guo, Katherine C. Verbist, Jamshid Temirov, Mark J. Chen, Davide Ruggero, Hui Zhang, Paul G. Thomas, Douglas R. Green. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00327-6

Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR – Dawid Krokowski, Raul Jobava, Krzysztof J. Szkop, Chien-Wen Chen, Xu Fu, Sarah Venus, Bo-Jhih Guan, Jing Wu, Zhaofeng Gao, Wioleta Banaszuk, Marek Tchorzewski, Tingwei Mu, Phil Ropelewski, William C. Merrick, Yuanhui Mao, Aksoylu Inci Sevval, Helen Miranda, Shu-Bing Qian, Maria Manifava, Nicholas T. Ktistakis, Anastasios Vourekas, Eckhard Jankowsky, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00894-4


Hypoxia


Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression – Mohamed A. Abu el Maaty, Julie Terzic, Céline Keime, Daniela Rovito, Régis Lutzing, Darya Yanushko, Maxime Parisotto, Elise Grelet, Izzie Jacques Namer, Véronique Lindner, Gilles Laverny, Daniel Metzger. https://www.science.org/doi/full/10.1126/sciadv.abo229

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy – Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A. Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave S. B. Hoon, Henrik J. Ditzel, Ern Yu Tan, Qingfeng Chen and Qiang Yu. https://www.nature.com/articles/s41467-022-31764-9


IDH


Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors – Ali Vaziri-Gohar, Joel Cassel, Farheen S. Mohammed, Mehrdad Zarei, Jonathan J. Hue, Omid Hajihassani, Hallie J. Graor, Yellamelli V. V. Srikanth, Saadia A. Karim, Ata Abbas, Erin Prendergast, Vanessa Chen, Erryk S. Katayama, Katerina Dukleska, Imran Khokhar, Anthony Andren, Li Zhang, Chunying Wu, Bernadette Erokwu, Chris A. Flask, Mahsa Zarei, Rui Wang, Luke D. Rothermel, Andrea M. P. Romani, Jessica Bowers, Robert Getts, Curtis Tatsuoka, Jennifer P. Morton, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Joseph M. Salvino, Jonathan R. Brody and Jordan M. Winter. https://www.nature.com/articles/s43018-022-00393-y

Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity – Kexu Xiang, Christian Kalthoff, Corinna Münch, Verena Jendrossek and Johann Matschke. https://www.nature.com/articles/s41419-022-05098-9


Glucose/lactate metabolism


Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma – Shawn M. Davidson; Daniel R. Schmidt; Julia E. Heyman; James P. O’Brien; Amy C. Liu; William J. Israelsen; Talya L. Dayton; Raghav Sehgal; Roderick T. Bronson; Elizaveta Freinkman; Howard H. Mak; Giuseppe Nicolò Fanelli; Scott Malstrom; Gary Bellinger; Arkaitz Carracedo; Pier Paolo Pandolfi; Kevin D. Courtney; Abhishek Jha; Ronald A. DePinho; James W. Horner; Craig J. Thomas; Lewis C. Cantley; Massimo Loda; Matthew G. Vander Heiden. https://aacrjournals.org/cancerres/article/82/13/2403/705036/

Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation – Ina Huppertz, Joel I. Perez-Perri, Panagiotis Mantas, Thileepan Sekaran, Thomas Schwarzl, Francesco Russo, Dunja Ferring-Appel, Zuzana Koskova, Lyudmila Dimitrova-Paternoga, Eleni Kafkia, Janosch Hennig, Pierre A. Neveu, Kiran Patil, Matthias W. Hentze. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00486-5

G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis – Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, Eric J. Brown, Ben Z. Stanger, Joshua D. Rabinowitz, Xiaolu Yang. https://www.science.org/doi/full/10.1126/sciadv.abo040

The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression – Md. Wasim Khan, Alexander R. Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, Jose Cordoba-Chacon, Issam Ben-Sahra, Barton Wicksteed and Brian T. Layden. https://www.nature.com/articles/s41419-022-04999-z

Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation – Shuang Liu, Hui Zhao, Yibing Hu, Chang Yan, Yulong Mi, Xiaolan Li, Deding Tao and Jichao Qin. https://www.nature.com/articles/s41419-022-05111-1


Amino acid metabolism


Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression – Manuel Grima-Reyes, Ashaina Vandenberghe, Ivan Nemazanyy, Pauline Meola, Rachel Paul, Julie Reverso-Meinietti, Adriana Martinez-Turtos, Nicolas Nottet, Wai-Kin Chan, Philip L. Lorenzi, Sandrine Marchetti, Jean-Ehrland Ricci, Johanna Chiche. https://www.science.org/doi/full/10.1126/sciadv.abn6491

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma – Bo Zhang, Hui Peng, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E. Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo J. Hatanpaa, John A. Copland, Ralph J. DeBerardinis, Yingfei Wang, Weibo Luo. https://aacrjournals.org/cancerres/article-abstract/82/13/2388/705041

Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression – Rachana Patel, Catriona A. Ford, Lisa Rodgers, Linda K. Rushworth, Janis Fleming, Ernest Mui, Tong Zhang, David Watson, Victoria Lynch, Gillian Mackay, David Sumpton, Owen J. Sansom, Johan Vande Voorde, Hing Y. Leung. https://aacrjournals.org/cancerres/article/82/14/2565/706947

Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer – Rumi Lee, Jiexi Li, Jun Li, Chang-Jiun Wu, Shan Jiang, Wen-Hao Hsu, Deepavali Chakravarti, Peiwen Chen, Kyle A. LaBella, Jing Li, Denise J. Spring, Di Zhao, Y. Alan Wang, Ronald A. DePinho. https://aacrjournals.org/cancerdiscovery/article-abstract/12/7/1702/705207

Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis – Jingru Bai, Tong Liu, Bo Tu, Meng Yuan, Zhaoqi Shu, Minghe Fan, Sihan Huo, Yuyao Guo, Lina Wang, Hua Wang and Ying Zhao. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2093026

Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance – Jiliang Xia, Jingyu Zhang, Xuan Wu, Wanqing Du, Yinghong Zhu, Xing Liu, Zhenhao Liu, Bin Meng, Jiaojiao Guo, Qin Yang, Yihui Wang, Qinglin Wang, Xiangling Feng, Guoxiang Xie, Yi Shen, Yanjuan He, Juanjuan Xiang, Minghua Wu, Gang An, Lugui Qiu, Wei Jia and Wen Zhou. https://www.nature.com/articles/s41467-022-31248-w


Lipid metabolism


PI3K drives the de novo synthesis of coenzyme A from vitamin B5 – Christian C. Dibble, Samuel A. Barritt, Grace E. Perry, Evan C. Lien, Renee C. Geck, Sarah E. DuBois-Coyne, David Bartee, Thomas T. Zengeya, Emily B. Cohen, Min Yuan, Benjamin D. Hopkins, Jordan L. Meier, John G. Clohessy, John M. Asara, Lewis C. Cantley and Alex Toker. https://www.nature.com/articles/s41586-022-04984-8

Lipidomic profiling of exosomes from colorectal cancer cells and patients reveals potential biomarkers – Mohammed I. Y. Elmallah, Pablo Ortega-Deballon, Laure Hermite, Jean-Paul Pais-De-Barros, Jessica Gobbo, Carmen Garrido. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13223

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer – Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M. Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I. Wistuba, John D. Minna, Jeffrey G. McDonald and Pier Paolo Scaglioni. https://www.nature.com/articles/s41467-022-31963-4


Nucleotides


Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors – Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato 1, Miyuki Nishida, Hai-Feng Zhang, Marco M Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G Proud, Denis L J Lafontaine, Tsuyoshi Osawa. https://www.nature.com/articles/s41467-022-31418-w

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia – Joan So, Alexander C Lewis, Lorey K Smith, Kym Stanley, Rheana Franich, David Yoannidis, Lizzy Pijpers, Pilar Dominguez, Simon J Hogg, Stephin J Vervoort, Fiona C Brown, Ricky W Johnstone, Gabrielle McDonald, Danielle B Ulanet, Josh Murtie, Emily Gruber, Lev M Kats. https://www.embopress.org/doi/full/10.15252/emmm.202115203

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia – Mohammad Houshmand, Nicoletta Vitale, Francesca Orso, Alessandro Cignetti, Ivan Molineris, Valentina Gaidano, Stefano Sainas, Marta Giorgis, Donatella Boschi, Carmen Fava, Alice Passoni, Marta Gai, Massimo Geuna, Federica Sora, Alessandra Iurlo, Elisabetta Abruzzese, Massimo Breccia, Olga Mulas, Giovanni Caocci, Fausto Castagnetti, Daniela Taverna, Salvatore Oliviero, Fabrizio Pane, Marco Lucio Lolli, Paola Circosta and Giuseppe Saglio. https://www.nature.com/articles/s41419-022-05028-9


Mitochondria and TCA


13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo – Likun Duan, Daniel E. Cooper, Grace Scheidemantle, Jason W. Locasale, David G. Kirsch and Xiaojing Liu. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00287-8

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context – Samuel Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford , Yatrik M Shah, Costas A Lyssiotis. https://elifesciences.org/articles/73245

The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro – Max Holzknecht, Lena Guerrero-Navarro, Michele Petit, Eva Albertini, Elisabeth Damisch, Anna Simonini, Fernando Schmitt, Walther Parson, Heidelinde Fiegl, Alexander Weiss, Pidder Jansen-Duerr. https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14462


Miscellaneous


Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue – Alba Gonzalez-Franquesa, Pau Gama-Perez, Marta Kulis, Karolina Szczepanowska, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre-Pellicer, Rebeca Fernández-Ruiz, Antoni Aguilar-Mogas, Anne Hoffman, Erika Monelli, Sara Samino, Joan Miró-Blanch, GregorOemer, Xavier Duran, Estrella Sanchez-Rebordelo, Marc Schneebergerg, Merce Obac, Joel Montane, Giancarlo Castellano, Vicente Chapaprieta, Wenfei Sun, Lourdes Navarro, Ignacio Prieto, Carlos Castaño, Anna Novials, Ramon Gomis, Maria Monsalve, Marc Claret, Mariona Graupera, Guadalupe Soria, Christian Wolfrum, Joan Vendrell, Sonia Fernández-Veledo, Jose Antonio Enríque, Angel Carracedo, José Carlos Perales, Rubén Nogueiras, Laura Herrero, Aleksandra Trifunovi, Markus A.Keller, Oscar Yanes, Marta Sales-Pardo, Roger Guimerà, Matthias Blüher, José Ignacio Martín-Subero, Pablo M.Garcia-Roves. https://doi.org/10.1016/j.redox.2022.102353

Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity – Daniela D. Weber, Sepideh Aminzadeh-Gohari, Maheshwor Thapa, Anna-Sophia Redtenbacher, Luca Catalano, Tânia Capelôa, Thibaut Vazeille, Michael Emberger, Thomas K. Felder, René G. Feichtinger, Peter Koelblinger, Guido Dallmann, Pierre Sonveaux, Roland Lang and Barbara Kofler. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00288-7

The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib – Piotr Kobialka, Helena Sabata, Odena Vilalta, Leonor Gouveia, Ana Angulo-Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz-Aznar, Nagore G Olaciregui, Lucia Fanlo, Anna Esteve-Codina, Cinzia Lavarino, Biola M Javierre, Veronica Celis, Carlota Rovira, Susana López-Fernández, Eulàlia Baselga, Jaume Mora, Sandra D Castillo, Mariona Graupera. https://www.embopress.org/doi/full/10.15252/emmm.202115619

FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity – Hilde Herrema, Dongxian Guan, Jae Won Choi, Xudong Feng, Mario Andres Salazar Hernandez, Farhana Faruk, Thomas Auen, Eliza Boudett, Rongya Tao, Hyonho Chun, Umut Ozcan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00187-5


Reviews


Targeting mitochondrial metabolism for precision medicine in cancer – Lourdes Sainero-Alcolado, Judit Liaño-Pons, María Victoria Ruiz-Pérez and Marie Arsenian-Henriksson. https://www.nature.com/articles/s41418-022-01022-y

Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis – Elisa Donato, Andreas Trumpp. https://www.embopress.org/doi/full/10.15252/emmm.202216171

Polyamines in cancer: integrating organismal metabolism and antitumour immunity – Cassandra E. Holbert, Michael T. Cullen, Robert A. Casero Jr and Tracy Murray Stewart. https://www.nature.com/articles/s41568-022-00473-2

Scaling of biosynthesis and metabolism with cell size – Clotilde Cadart and Rebecca Heald. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E21-12-0627

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities – Balaraman Kalyanaraman, Gang Cheng and Micael Hardy. https://www.frontiersin.org/articles/10.3389/fonc.2022.816504/full

The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality? – Bassam Janji, Salem Chouaib. https://www.frontiersin.org/articles/10.3389/fimmu.2022.880810/full

Beyond controlling cell size: functional analyses of S6K in tumorigenesis – Xueji Wu, Wei Xie, Wenxuan Xie, Wenyi Wei and Jianping Guo. https://www.nature.com/articles/s41419-022-05081-4


Comments


Driving with Both Feet: Supplementing AKG While Inhibiting BCAT1 Leads to Synthetic Lethality in GBM – Noah Meurs, Deepak Nagrath. https://aacrjournals.org/cancerres/article-abstract/82/13/2354/705023

IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk – Kung-Chi Kao, Alison Jaccard, Ping-Chih Ho. https://aacrjournals.org/cancerdiscovery/article-abstract/12/7/1615/705216

Akt protein boosts cancer metabolism through a two-pronged attack – Philipp Poeller and Almut Schulze. https://www.nature.com/articles/d41586-022-01603-4

Low Phosphoglycerate Dehydrogenase Levels Drive Metastatic Disseminationhttps://aacrjournals.org/cancerdiscovery/article-abstract/12/7/1611/705198

Colorectal Cancer Growth Is Reduced by the Ketone Body β-Hydroxybutyratehttps://aacrjournals.org/cancerdiscovery/article-abstract/12/7/OF15/705202

Ceramide Accumulation Induces the Integrated Stress Response in AMLhttps://aacrjournals.org/cancerdiscovery/article-abstract/12/7/OF14/705203

MetaboList – June 2022


Nutrient sensing – mTOR


Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine – Andrew L. Cangelosi, Anna M. Puszynska, Justin M. Roberts, Andrea Armani, Thao P. Nguyen, Jessica B. Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A. Lewis, William C. Comb, George W. Bell, Aharon Helman, David M. Sabatini. https://www.science.org/doi/abs/10.1126/science.abi9547

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1 – Gwen R. Buel, Huy Q. Dang, John M. Asara, John Blenis, Anders P. Mutvei. https://www.jbc.org/article/S0021-9258(22)00470-7/fulltext

Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation – Hongrui Xiang, Yuexiao Tao, Zhenyan Jiang, Xian Huang, Huizi Wang, Wei Cao, Jia Li, Rui Ding, Mingyi Shen, Ru Feng, Linsen Li, Chenyang Guan, Jiamin Liu, Jun Ni, Lei Chen, Zhengting Wang, Youqiong Ye, Qing Zhong, Junling Liu, Qiang Zou, Xuefeng Wu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00725-2


Nutrient sensing – ISR


A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression – Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, J. Alan Diehl, Serge Y. Fuchs, Ellen Puré and Constantinos Koumenis. https://www.nature.com/articles/s41556-022-00918-8

Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific – Jonsson WO, Mirek ET, Wek RC, Anthony TG. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202200204RR

Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response – Aleksandra P Pitera, Maria Szaruga, Sew-Yeu Peak-Chew, Steven W Wingett, Anne Bertolotti. https://www.embopress.org/doi/full/10.15252/embj.2021109985


Nutrient sensing: AMPK


A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis – Hsing-I Tseng, Yi-Siang Zeng, Ying-Chung Jimmy Lin, Jui-Wen Huang, Chih-Lung Lin, Meng-Hsuan Lee, Fan-Wei Yang, Te-Ping Fang, Ai-Chung Mar, Jung-Chen Su. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13211

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator – Ashley J. Ovens, Yi Sing Gee, Naomi X.Y. Ling, Dingyi Yu, Justin P. Hardee, Jin D. Chung; Kevin R.W. Ngoei, Nicholas J. Waters, Nolan J. Hoffman, John W. Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W. Parker, Gordon S. Lynch, Fei Huang, Sandra Galic, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill, Christopher G. Langendorf. https://portlandpress.com/biochemj/article/479/11/1181/231304

Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation – Shijie Ma, Zizheng Dong, Yanfei Huang, Jing-Yuan Liu, Jian-Ting Zhang. https://www.jbc.org/article/S0021-9258(22)00484-7/fulltext


Nutrient sensing – miscellaneous


The polyol pathway is an evolutionarily conserved system for sensing glucose uptake – Hiroko Sano, Akira Nakamura, Mariko Yamane, Hitoshi Niwa, Takashi Nishimura, Kimi Araki, Kazumasa Takemoto, Kei-ichiro Ishiguro, Hiroki Aoki, Yuzuru Kato, Masayasu Kojima. https://www.nature.com/articles/s42255-022-00568-y

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth – Chunming Cheng, Feng Geng, Zoe Li, Yaogang Zhong, Huabao Wang, Xiang Cheng, Yue Zhao, Xiaokui Mo, Craig Horbinski, Wenrui Duan, Arnab Chakravarti, Xiaolin Cheng and Deliang Guo. https://www.nature.com/articles/s42255-022-00568-y

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors – Melvin Pan, Christiane Zorbas and Tsuyoshi Osawa. https://www.nature.com/articles/s41467-022-31418-w

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth – Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso and Michael Potente. https://www.nature.com/articles/s42255-022-00584-y


Hypoxia


Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia – Javier Garcia-Bermudez, Michael A. Badgley, Sheela Prasad, Lou Baudrier, Yuyang Liu, Konnor La, Mariluz Soula, Robert T. Williams, Norihiro Yamaguchi, Rosa F. Hwang, Laura J. Taylor, Elisa de Stanchina, Bety Rostandy, Hanan Alwaseem, Henrik Molina, Dafna Bar-Sagi and Kıvanç Birsoy. https://www.nature.com/articles/s42255-022-00583-z

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome – Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sörensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao and Susanne Schlisio. https://www.nature.com/articles/s42255-022-00593-x

Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a non-canonical mechanism – Hideaki Nakamura, Hiroki Sekine, Hiroyuki Kato, Hisao Masai, Katarina Gradin, Lorenz Poellinger. https://www.jbc.org/article/S0021-9258(22)00579-8/fulltext


Glucose metabolism


G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment – Shree Bose, Qiang Huang, Yunhan Ma, Lihua Wang, Grecia O. Rivera, Yunxin Ouyang, Regina Whitaker, Rebecca A. Gibson, Christopher D. Kontos, Andrew Berchuck, Rebecca A. Previs, Xiling Shen. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00801-4

A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect – Xuejun Wen; Changrong Shi;, Xinying Zeng, Liang Zhao, Lanlin Yao, Zhida Liu, Lixia Feng, Deliang Zhang, Jinxiong Huang, Yesen Li, Qin Lin, Haojun Chen, Rongqiang Zhuang, Xiaoyuan Chen,  Xianzhong Zhang, Zhide Guo. https://aacrjournals.org/clincancerres/article-abstract/28/13/2923/704989

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness – Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick and Aaron D. Schimmer. https://www.nature.com/articles/s41556-022-00925-9


Amino acid metabolism


Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix – Emily J. Kay, Karla Paterson, Carla Riero-Domingo, David Sumpton, J. Henry M. Däbritz, Saverio Tardito, Claudia Boldrini, Juan R. Hernandez-Fernaud, Dimitris Athineos, Sandeep Dhayade, Ekaterina Stepanova, Enio Gjerga, Lisa J. Neilson, Sergio Lilla, Ann Hedley, Grigorios Koulouras, Grace McGregor, Craig Jamieson, Radia Marie Johnson, Morag Park, Kristina Kirschner, Crispin Miller, Jurre J. Kamphorst, Fabricio Loayza-Puch, Julio Saez-Rodriguez, Massimiliano Mazzone, Karen Blyth, Michele Zagnoni and Sara Zanivan. https://www.nature.com/articles/s42255-022-00582-0

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer – Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang. https://aacrjournals.org/cancerres/article-abstract/82/12/2254/699357

Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family – Natasha Freidman, Chelsea Briot, Renae Ryan. https://www.jbc.org/article/S0021-9258(22)00620-2

mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine – Mahabub Alam, Hiroki Shima, Yoshitaka Matsuo, Nguyen Chi Long, Mitsuyo Matsumoto, Yusho Ishii, Nichika Sato, Takato Sugiyama, Risa Nobuta, Satoshi Hashimoto, Liang Liu, Mika K. Kaneko, Yukinari Kato, Toshifumi Inada, Kazuhiko Igarashi. https://www.jbc.org/article/S0021-9258(22)00525-7/fulltext

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML – Chang Liu, Waiyi Zou, Danian Nie, Shuyi Li, Chen Duan, Min Zhou, Peilong Lai, Shengyong Yang, Sen Ji, Yangqiu Li, Mei Mei, Shilai Bao, Yanli Jin, Jingxuan Pan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00131-0

Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response – Dong-Jing Cai, Zi-Yu Zhang, Yue Bu, Li Li, Yue-Zhen Deng, Lun-Quan Sun, Cheng-Ping Hu and Min Li. https://www.nature.com/articles/s41419-022-05015-0


Lipid metabolism


Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited – Zhaoqi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios, Keene L. Abbott, Justine C. Rutter, Anna M. Westermark, Elizabeth F. Gorodetsky, Lucas B. Sullivan, Matthew G. Vander Heiden and Dennis Vitkup. https://www.nature.com/articles/s42255-022-00588-8

The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition – Junfang Lyu, Mehdi Pirooznia, Yuesheng Li, and Jianhua Xiong. https://www.molbiolcell.org/doi/10.1091/mbc.E22-02-0066?ai=s5&ui=2oy6&af=T

Ct-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation – Yutang Huang, Yan Du, Yujie Zheng, Chunjie Wen, Hecun Zou, Jiafeng Huang, Honghao Zhou, Hongbo Zhao and Lanxiang Wu. https://www.nature.com/articles/s41419-022-05014-1

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma – Ling Tao, Mahmoud A. Mohammad and Eveline Barbieri. https://www.nature.com/articles/s41467-022-31331-2


Mitochondria and iron


NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins – Naiara Santana-Codina, Maria Quiles del Rey, Kevin S. Kapner, Huan Zhang, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen M. John, Douglas E. Biancur, Brandon Chen, Nupur K. Das, Kristen E. Lowder, Connor J. Hennessey, Wesley Huang, Annan Yang, Yatrik M. Shah, Jonathan A. Nowak, Andrew J. Aguirre, Joseph D. Mancias. https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0043/704854

Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer – Mirunalini Ravichandran, Jingjie Hu, Charles Cai, Nathan P. Ward, Anthony Venida, Callum Foakes, Miljan Kuljanin, Annan Yang, Connor J. Hennessey, Yang Yang, Brandon R. Desousa, Gilles Rademaker, Annelot A.L. Staes, Zeynep Cakir, Isha H. Jain, Andrew J. Aguirre, Joseph D. Mancias, Yin Shen, Gina M. DeNicola, Rushika M. Perera. https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-22-0044/706733

Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila – Shamsi Emtenani, Elliot T Martin, Attila Gyoergy, Julia Bicher, Jakob-Wendelin Genger, Thomas Köcher, Maria Akhmanova, Mariana Guarda, Marko Roblek, Andreas Bergthaler, Thomas R Hurd, Prashanth Rangan, Daria E Siekhaus. https://www.embopress.org/doi/full/10.15252/embj.2021109049


Cancer Immunometabolism


Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics – Qi Liu, Fangming Zhu, Xinnan Liu, Ying Lu, Ke Yao, Na Tian, Lingfeng Tong, David A. Figge, Xiuwen Wang, Yichao Han, Yakui Li, Yemin Zhu, Lei Hu, Yingning Ji, Nannan Xu, Dan Li, Xiaochuan Gu, Rui Liang, Guifang Gan, Lifang Wu, Ping Zhang, Tianle Xu, Hui Hu, Zeping Hu, Huji Xu, Dan Ye, Hui Yang, Bin Li and Xuemei Tong. https://www.nature.com/articles/s42255-022-00575-z

Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion – Zhiqiang Wang, Zhou Lu, Shengli Lin, Jie Xia, Ziwen Zhong, Zhangjuan Xie, Yun Xing, Jingbo Qie, Mengxia Jiao, Yifan Li, Haoyu Wen, Pengyuan Zhao, Dan Zhang, Pinghong Zhou, Jiawen Qian, Feifei Luo, Luman Wang, Hongxiu Yu, Jie Liu, Jie Gu, Ronghua Liu, Yiwei Chu. https://www.cell.com/immunity/fulltext/S1074-7613(22)00188-1

Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4+ T-cell proliferation and glycolytic activity under hypoxia and normoxia – Jonas A. Wik, Azazul Chowdhury, Shrikant Kolan, Nasser E. Bastani, Gaoyang Li, Kazi Alam, Franco Grimolizzi, Bjørn S. Skålhegg. https://portlandpress.com/biochemj/article/479/11/1221/231349

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells – Jian Gu, Jinren Zhou, Qiuyang Chen, Xiaozhang Xu, Ji Gao, Xiangyu Li, Qing Shao, Bo Zhou, Haoming Zhou, Song Wei, Qi Wang, Yuan Liang, Ling Lu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00772-0


Miscellaneous


Metformin-induced reductions in tumor growth involves modulation of the gut microbiome – Lindsay A. Broadfield, Amna Saigal, Jake C. Szamosi, Joanne A. Hammill, Ksenia Bezverbnaya, Dongdong Wang, Jaya Gautam, Evangelia E. Tsakiridis, Fiorella Di Pastena, Jamie McNicol, Jianhan Wu, Saad Syed, James S.V. Lally, Amogelang R. Raphenya, Marie-Jose Blouin, Michael Pollak, Andrea Sacconi, Giovanni Blandino, Andrew G. McArthur, Jonathan D. Schertzer. https://www.sciencedirect.com/science/article/pii/S2212877822000679

An exercise-inducible metabolite that suppresses feeding and obesity – Veronica L. Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T. Kim, Amanda L. Wiggenhorn, Julia T. Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H. Zushin, Robert S. Jansen, Basil Michael, Kang Yong Loh, Andrew C. Yang, Christian S. Carl, Christian T. Voldstedlund, Wei Wei, Stephanie M. Terrell, Benjamin C. Moeller, Rick M. Arthur, Gareth A. Wallis, Koen van de Wetering, Andreas Stahl, Bente Kiens, Erik A. Richter, Steven M. Banik, Michael P. Snyder, Yong Xu and Jonathan Z. Long. https://www.nature.com/articles/s41586-022-04828-5


Reviews


Ribosome biogenesis and the cellular energy economy – David Shore, Benjamin Albert. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00719-9

Ferroptosis at the intersection of lipid metabolism and cellular signaling – Deguang Liang, Alexander M. Minikes, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00260-X

Shaping fuel utilization by mitochondria – Lukas Alan, Luca Scorrano. https://www.cell.com/current-biology/fulltext/S0960-9822(22)00765-5

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities – Balaraman Kalyanaraman, Gang Cheng, Micael Hardy. https://www.frontiersin.org/articles/10.3389/fonc.2022.816504/full

Fatty acid synthase: a druggable driver of breast cancer brain metastasis – Javier A. Menendez and Ruth Lupu. https://www.tandfonline.com/doi/full/10.1080/14728222.2022.2077189


Comments


NAD+ regeneration drives cancer cell proliferation – Xu Han and M. Celeste Simon. https://www.nature.com/articles/s42255-022-00579-9

YAP/TAZ–TEAD link angiogenesis to nutrients – Roxana E. Oberkersch and Massimo M. Santoro. https://www.nature.com/articles/s42255-022-00579-9

TCA cycle off, ATF4 on for metabolic homeostasis – Durga Mahor, Rishikesh Pandey, Vinay Bulusu. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(22)00065-2

Research is a process – Sarah-Maria Fendt. https://www.nature.com/articles/s41556-022-00954-4

MetaboList – May 2022


Nucleotides / one carbon


Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway – Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra and Gerta Hoxhaj. https://www.nature.com/articles/s41467-022-30362-z

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells – Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis. https://www.science.org/doi/full/10.1126/sciadv.abm8786

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis – Nicole Kiweler, Catherine Delbrouck, Vitaly I. Pozdeev, Laura Neises, Leticia Soriano-Baguet, Kim Eiden, Feng Xian, Mohaned Benzarti, Lara Haase, Eric Koncina, Maryse Schmoetten, Christian Jaeger, Muhammad Zaeem Noman, Alexei Vazquez, Bassam Janji, Gunnar Dittmar, Dirk Brenner, Elisabeth Letellier and Johannes Meiser. https://www.nature.com/articles/s41467-022-30363-y

CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer – G. Filippone, D. Gaglio, R. Bonfanti, F. A. Tucci, E. Ceccacci, R. Pennisi, M. Bonanomi, G. Jodice, M. Tillhon, F. Montani, G. Bertalot, S. Freddi, M. Vecchi, A. Taglialatela, M. Romanenghi, F. Romeo, N. Bianco, E. Munzone, F. Sanguedolce, G. Vago, G. Viale, P. P. Di Fiore, S. Minucci, L. Alberghina, M. Colleoni, P. Veronesi, D. Tosoni and S. Pece. https://www.nature.com/articles/s41467-022-30375-8


Mitochondria / IDH


Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia – Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Bernard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas and Richard J. D’Andrea. https://www.nature.com/articles/s41467-022-30223-9

IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system – Anjaneyulu Murari, Naga S. V. Goparaju, Shauna-Kay Rhooms, Kaniz F. B. Hossain, Felix G. Liang, Christian J. Garcia, Cindy Osei, Tong Liu, Hong Li, Richard N. Kitsis, Rajesh Patel, Edward Owusu-Ansah. https://www.science.org/doi/full/10.1126/sciadv.abl8716

Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer – Monica De Luise, Manuela Sollazzo, Eleonora Lama, Camelia Alexandra Coadă, Licia Bressi, Maria Iorio, Beatrice Cavina, Luigi D’Angelo, Sara Milioni, Lorena Marchio, Stefano Miglietta, Sara Coluccelli, Greta Tedesco, Anna Ghelli, Silvia Lemma, Anna Myriam Perrone, Ivana Kurelac, Luisa Iommarini, Anna Maria Porcelli and Giuseppe Gasparre. https://www.nature.com/articles/s41598-022-11620-y

Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment – Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan and Dipayan Chaudhuri. https://www.nature.com/articles/s41467-022-30236-4

OXPHOS deficiencies affect peroxisome proliferation by downregulating genes controlled by the SNF1 signaling pathway [yeast] – Jean-Claude Farre , Krypton Carolino, Lou Devanneaux, Suresh Subramani. https://elifesciences.org/articles/75143

Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy – Laura Torresano, Fulvio Santacatterina, Sonia Domínguez-Zorita, Cristina Nuevo-Tapioles, Alfonso Núñez-Salgado, Pau B. Esparza-Moltó, Lucía González-Llorente, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Brenda Sánchez-Garrido, Laura Nájera, Clara Salas, Mariano Provencio and José M. Cuezva. https://www.nature.com/articles/s41389-022-00400-y

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia – Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang and Marina Konopleva. https://www.nature.com/articles/s41467-022-30396-3


Glucose metabolism


PHGDH heterogeneity potentiates cancer cell dissemination and metastasis – Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grünewald, Morag Park, Jacco van Rheenen and Sarah-Maria Fendt. https://www.nature.com/articles/s41586-022-04758-2

The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity – Helena Dragic, Audrey Barthelaix, VCédric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugière, Yohann Couté, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Verge N Manié. https://www.life-science-alliance.org/content/5/7/e202101334

TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression – Inês Baptista, Effrosyni Karakitsou, Jean-Baptiste Cazier, Ulrich L Günther, Silvia Marin, Marta Cascante. https://www.mdpi.com/1422-0067/23/7/3574

The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62 – Juan F. Linares, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Anxo Martinez-Ordoñez, Miguel Reina-Campos, Hui-Hsuan Kuo, Olivier Elemento, M. Laura Martin, Thekla Cordes, Timothy C. Thompson, Christian M. Metallo, Jorge Moscat, Maria T. Diaz-Meco. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00559-9

Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines – Tia R. Tidwell, Gro V. Røsland, Karl Johan Tronstad, Kjetil Søreide and Hanne R. Hagland. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00285-w

Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF–ERK1/2 signaling pathways – Miji Jeon, Krishna M. Chauhan, Gregory L. Szeto, Minjoung Kyoung, Songon An. https://www.jbc.org/article/S0021-9258(22)00115-6/fulltext

Molecular basis for inhibiting human glucose transporters by exofacial inhibitors – Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang and Nieng Yan. https://www.nature.com/articles/s41467-022-30326-3


Amino acids


Cysteine is a limiting factor for glioma proliferation and survival – Victor Ruiz-Rodado, Tyrone Dowdy, Adrian Lita, Tamalee Kramp, Meili Zhang, Jinkyu Jung, Ana Dios-Esponera, Lumin Zhang, Christel C. Herold-Mende, Kevin Camphausen, Mark R. Gilbert, Mioara Larion. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13148

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome – Brian J. Golbourn, Matthew E. Halbert, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E. Mbah, Nisha Kabir, Ann-Catherine J. Stanton, Abigail L. Locke, Stephanie M. Casillo, Yanhua Zhao, Lauren M. Sanders, Allison Cheney, Steven J. Mullett, Apeng Chen, Michelle Wassell, Anthony Andren, Jennifer Perez, Esther P. Jane, Daniel R. David Premkumar, Robert F. Koncar, Shideh Mirhadi, Lauren H. McCarl, Yue-Fang Chang, Yijen L. Wu, Taylor A. Gatesman, Andrea F. Cruz, Michal Zapotocky, Baoli Hu, Gary Kohanbash, Xiuxing Wang, Alenoush Vartanian, Michael F. Moran, Frank Lieberman, Nduka M. Amankulor, Stacy G. Wendell, Olena M. Vaske, Ashok Panigrahy, James Felker, Kelsey C. Bertrand, Claudia L. Kleinman, Jeremy N. Rich, Robert M. Friedlander, Alberto Broniscer, Costas Lyssiotis, Nada Jabado, Ian F. Pollack, Stephen C. Mack and Sameer Agnihotri. https://www.nature.com/articles/s43018-022-00348-3

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis – Bin Jiang, Jia Zhang, Guohui Zhao, Mengjue Liu, Jielu Hu, Furong Lin, Jinyang Wang, Wentao Zhao, Huanhuan Ma, Cixiong Zhang, Caiming Wu, Luming Yao, Qingfeng Liu, Xin Chen, Yating Cao, Yi Zheng, Chensong Zhang, Aidong Han, Donghai Lin, Qinxi Li. https://www.sciencedirect.com/science/article/abs/pii/S1097276522002544?via%3Dihub

Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model – Koichi Azuma, Huihui Xiang, Tomoyuki Tagami et al. https://jitc.bmj.com/content/10/5/e004420

Cytosolic aspartate aminotransferase moonlights as a ribosome binding modulator of Gcn2 activity during oxidative stress – Robert A Crawford, Mark Peter Ashe, Simon J Hubbard, Graham D Pavitt. https://elifesciences.org/articles/73466


Lipid metabolism


Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer – Chenchen Guo, Ruijie Wan, Yayi He, Shu-Hai Lin, Jiayu Cao, Ying Qiu, Tengfei Zhang, Qiqi Zhao, Yujia Niu, Yujuan Jin, Hsin-Yi Huang, Xue Wang, Li Tan, Roman K. Thomas, Hua Zhang, Luonan Chen, Kwok-Kin Wong, Liang Hu and Hongbin Ji. https://www.nature.com/articles/s43018-022-00358-1

27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis – Xingkai Li, Hengchi Chen, Lizhen Zhang, Li Chen, Wei Wei, Shugeng Gao, Qi Xue, Yue Li, Bing Wang, Jiagen Li, Yushun Gao and Yanliang Lin. https://www.nature.com/articles/s41388-022-02285-y

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy – Smitha Pillai, Iqbal Mahmud, Rohit Mahar, Crystal Griffith, Michael Langsen, Jonathan Nguyen, Jonathan W. Wojtkowiak, Pawel Swietach, Robert A. Gatenby, Marilyn M. Bui, Matthew E. Merritt, Patricia McDonald, Timothy J. Garrett, Robert J. Gillies. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00569-1

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis – Qiqiao Du, Pan Liu, Chunyu Zhang, Tianyu Liu, Wei Wang, Chunliang Shang, Jieyu Wu, Yuandong Liao, Yili Chen, Jiaming Huang, Hao Tan, Yunhe Zhao, Meng Xia, Junxiu Liu and Shuzhong Yao. https://www.nature.com/articles/s41419-022-04926-2

Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids – Yi-Jia Li, Johannes Francois Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, Satyendra C. Tripathi, Chunyan Zhang, Yuan Yuan, David Ann, Samir Hanash, Hua Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00645-3

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling – Maria Thürmer, André Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, René Winkler, Konstantin Löser, Julia Grander, Madlen Hotze, Sönke Harder, Annika Döding, Martina Meßner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlüter, Johanna Pachmayr, Óscar Gutiérrez-Gutiérrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Späte, Cristina González-Estévez, Christian Kosan, Aleš Svatoš, Marcel Kwiatkowski and Andreas Koeberle. https://www.nature.com/articles/s41467-022-30374-9

Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients – Yogesh M. Bramhecha, Karl-Philippe Guérard, Étienne Audet-Walsh, Shaghayegh Rouzbeh, Ola Kassem, Erwan Pernet, Eleonora Scarlata, Lucie Hamel, Fadi Brimo, Maziar Divangahi, Armen G. Aprikian, Simone Chevalier, Vincent Giguère and Jacques Lapointe. https://www.nature.com/articles/s41388-022-02276-z


Starvation, nutrient sensing


O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine – Kibum Kim, Hee Chan Yoo, Byung Gyu Kim, Sulhee Kim, Yulseung Sung, Ina Yoon, Ya Chun Yu, Seung Joon Park, Jong Hyun Kim, Kyungjae Myung, Kwang Yeon Hwang, Sunghoon Kim and Jung Min Han. https://www.nature.com/articles/s41467-022-30696-8

Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming – Lu Qiu, Qiufang Yang, Wenshan Zhao, Yadi Xing, Peng Li, Xiaowen Zhou, Haoming Ning, Ranran Shi, Shanshan Gou, Yalan Chen, Wenjie Zhai, Yahong Wu, Guodong Li, Zhenzhen Chen, Yonggang Ren, Yanfeng Gao, Yiguo Zhang and Yuanming Qi. https://www.nature.com/articles/s41419-022-04917-3

Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer – Yogev Sela, Jinyang Li, Shivahamy Maheswaran, Robert J Norgard, Salina Yuan, Maimon E Hubbi, Miriam Doepner, Jimmy P Xu, Elaine S Ho, Clementina Mesaros, Colin Sheehan, Grace Croley, Alexander Muir, Ian A Blair, Ophir Shalem, Chi V Dang, Ben Z Stanger. https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-0431/682341

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity – Qian Li, Xiaofang Zhong, Weicheng Yao, Junli Yu, Chao Wang, Zongyan Li, Shengqing Lai, Fanli Qu, Xiaoyan Fu, Xiaojia Huang, Dawei Zhang, Yujie Liu, Haiyan Li. https://www.jbc.org/article/S0021-9258(22)00193-4/fulltext


mTOR / AMPK


PET-Based Radiogenomics Supports mTOR Pathway Targeting for Hepatocellular Carcinoma – Jihyun An, Minyoung Oh, Seog-Young Kim, Yoo-Jin Oh, Bora Oh, Ji-Hye Oh, Wonkyung Kim, Jin Hwa Jung, Ha Il Kim, Jae-Seung Kim, Chang Ohk Sung, Ju Hyun Shim. https://aacrjournals.org/clincancerres/article-abstract/28/9/1821/694445

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth – Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00595-2

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation – Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein. https://www.jbc.org/article/S0021-9258(22)00190-9/fulltext

Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3 – Yuxiang Liu, Tao V. Wang, Yunfeng Cui, Shengxian Gao, Yi Rao. https://www.jbc.org/article/S0021-9258(22)00369-6/fulltext


Metabolism and angiogenesis


Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis – Roxana E. Oberkersch, Giovanna Pontarin, Matteo Astone, Marianna Spizzotin, Liaisan Arslanbaeva, Giovanni Tosi, Emiliano Panieri, Sara Ricciardi, Maria Francesca Allega, Alessia Brossa, Paolo Grumati, Benedetta Bussolati, Stefano Biffo, Saverio Tardito, Massimo M. Santoro. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00286-6

The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo – Jin Yao, Xin-yuan Wu, Qing Yu, Shuo-fei Yang, Jin Yuan, Zhi-qing Zhang, Jin-song Xue, Qin Jiang, Min-bin Chen, Guan-hua Xue, Cong Cao. https://www.science.org/doi/full/10.1126/sciadv.abn6928

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors – Xiaomin Wang, Ziqi Chen, Jun Xu, Shuai Tang, Nan An, Lei Jiang, Yixiang Zhang, Shaoying Zhang, Qingli Zhang, Yanyan Shen, Shijie Chen, Xiaojing Lan, Ting Wang, Linhui Zhai, Siyuwei Cao, Siqi Guo, Yingluo Liu, Aiwei Bi, Yuehong Chen, Xiameng Gai, Yichen Duan, Ying Zheng, Yixian Fu, Yize Li, Liang Yuan, Linjiang Tong, Kun Mo, Mingcheng Wang, Shu-Hai Lin, Minjia Tan, Cheng Luo, Yi Chen, Jia Liu, Qiansen Zhang, Leping Li, Min Huang.. https://www.nature.com/articles/s41422-022-00650-w


Cancer Immunometabolism


Obesity modulates the immune macroenvironment associated with breast cancer development – Aleida Núñez-Ruiz, Flor Sánchez-Brena, Cynthia López-Pacheco, Naray A Acevedo-Domínguez, Gloria Soldevila.. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266827


Miscellaneous


A pan-cancer metabolic atlas of the tumor microenvironment – Neha Rohatgi, Umesh Ghoshdastider, Probhonjon Baruah, Tanmay Kulshrestha, Anders Jacobsen Skanderup. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00567-8

Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer, The MA.32 Randomized Clinical Trial – Pamela J. Goodwin, Bingshu E. Chen, Karen A. Gelmon, Timothy J. Whelan, Marguerite Ennis, Julie Lemieux, Jennifer A. Ligibel, Dawn L. Hershman, Ingrid A. Mayer, MD9, Timothy J. Hobday, Judith M. Bliss, Priya Rastogi, Manuela Rabaglio-Poretti, Som D. Mukherjee, John R. Mackey, Vandana G. Abramson, Conrad Oja, Robert Wesolowski, Alastair M. Thompson, Daniel W. Rea, Paul M. Stos, Lois E. Shepherd, Vuk Stambolic, Wendy R. Parulekar. https://jamanetwork.com/journals/jama/fullarticle/2792615

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes – Sophia Maschalidi, Parul Mehrotra, Burcu N. Keçeli, Hannah K. L. De Cleene, Kim Lecomte, Renée Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-022-04754-6

Comprehensive Analysis of Metabolic Isozyme Targets in Cancer – Michal Marczyk, Vignesh Gunasekharan, David Casadevall, Tao Qing, Julia Foldi, Raghav Sehgal, Naing Lin Shan, Kim R.M. Blenman, Tess A. O’Meara, Sheila Umlauf, Yulia V. Surovtseva, Viswanathan Muthusamy, Jesse Rinehart, Rachel J. Perry, Richard Kibbey, Christos Hatzis, Lajos Pusztai. https://aacrjournals.org/cancerres/article-abstract/82/9/1698/694711


Reviews


Transcriptional control of energy metabolism by nuclear receptors – Charlotte Scholtes and Vincent Giguère. https://www.nature.com/articles/s41580-022-00486-7

Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer – Gerardo M. Nava and Luis Alberto Madrigal-Perez. https://www.tandfonline.com/doi/abs/10.1080/14737159.2022.2065196?journalCode=iero20

Targeting oncometabolism to maximize immunotherapy in malignant brain tumors – Joshua D. Bernstock, Kyung-Don Kang, Neil V. Klinger, Hannah E. Olsen, Sam Gary, Stacie K. Totsch, Gelare Ghajar-Rahimi, David Segar, Eric M. Thompson, Victor Darley-Usmar, Bryan T. Mott, Luca Peruzzotti-Jametti and Gregory K. Friedman. https://www.nature.com/articles/s41388-022-02312-y

Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer – Pasquale Saggese, Assunta Sellitto, Cesar A. Martinez, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Roberta Tarallo and Claudio Scafoglio. https://www.mdpi.com/2072-6694/12/12/3788

Targeting Stearoyl-CoA Desaturase in Solid Tumors – Casie S. Kubota; Peter J. Espenshade. https://aacrjournals.org/cancerres/article-abstract/82/9/1682/694698

Metabolic tricks of cancer cells – Katerina Hönigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska, Michal Masarik. https://www.sciencedirect.com/science/article/abs/pii/S0304419X22000300

The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors – Xuemin Wang; Christopher G. Proud. https://portlandpress.com/biochemj/article-abstract/479/10/1059/231335

mTOR substrate phosphorylation in growth control – Stefania Battaglioni, Don Benjamin, Matthias Wälchli, Timm Maier, Michael N. Hall. https://www.cell.com/cell/fulltext/S0092-8674(22)00460-3

KEAP1-Mutant NSCLC: The Catastrophic Failure of a Cell-Protecting Hub – Stefano Scalera, Marco Mazzotta, Clelia Cortile, Eriseld Krasniqi, Ruggero De Maria, Federico Cappuzzo, Gennaro Ciliberto, Marcello Maugeri-Saccà. https://www.jto.org/article/S1556-0864(22)00166-6


Comments


Metabolic diversity drives cancer cell invasion – Sanjeethan C. Baksh and Lydia W. S. Finley. https://www.nature.com/articles/d41586-022-01301-1

Who Will Benefit From Metformin? – Joanne E. Mortimer; Victoria Seewaldt. https://jamanetwork.com/journals/jamaoncology/fullarticle/2792811

Formate for tumor progression – Annalisa M. VanHook. https://www.science.org/doi/full/10.1126/scisignal.add1844

Upcoming conferences:

PIVAC – Torino, Italy. September 22.. Conference about immunotherapy, with focus on microenvironment and metabolism. https://www.pivac22.it/

CIMUS symposium, Santiago, July 22. Organized by Rubén Nogueiras, Carlos Diéguez, Miguel López, Jose L. Labandeira, Fernando Dominguez, Diana Guallar, Ricardo Villa-Bellosta, includes several sessions about metabolism and disease https://www.cimussymposium.com/en/index.php

MetaboList – April 2022


Ketones / Lipids / Acetate


β-Hydroxybutyrate suppresses colorectal cancer – Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Hélène C. Descamps, Lenka Dohnalová, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss and Maayan Levy. https://www.nature.com/articles/s41586-022-04649-6

Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression – Victoire Gouirand, Tristan Gicquel, Evan C Lien, Emilie Jaune-Pons,  Quentin Da Costa,  Pascal Finetti,  Elodie Metay, Camille Duluc, Jared R Mayers, Stephane Audebert,  Luc Camoin, Laurence Borge, Marion Rubis, Julie Leca, Jeremy Nigri, François Bertucci, Nelson Dusetti, Juan Lucio Iovanna, Richard Tomasini, Ghislain Bidaut, Fabienne Guillaumond, Matthew G Vander Heiden, Sophie Vasseur. https://www.embopress.org/doi/abs/10.15252/embj.2021110466

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer – Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman and Afshin Samali. https://www.nature.com/articles/s41467-022-30159-0

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration – Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida, Toshio Suda. https://www.embopress.org/doi/abs/10.15252/embj.2021109463

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma – Min Tang, Xin Dong […] Ya Cao. https://www.nature.com/articles/s41419-022-04730-y

Altered propionate metabolism contributes to tumour progression and aggressiveness – Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt and John Blenis. https://www.nature.com/articles/s42255-022-00553-5

Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer – Luigi Ippolito, Giuseppina Comito, Matteo Parri, Marta Iozzo, Assia Duatti, Francesca Virgilio, Nicla Lorito, Marina Bacci, Elisa Pardella, Giada Sandrini, Francesca Bianchini, Roberta Damiano, Lavinia Ferrone, Giancarlo la Marca, Sergio Serni, Pietro Spatafora, Carlo V. Catapano, Andrea Morandi, Elisa Giannoni, Paola Chiarugi. https://aacrjournals.org/cancerres/article-abstract/82/7/1267/694059


Mitochondria


Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma – Xin Ge, Mengdie Li, Jianxing Yin, Zhumei Shi, Yao Fu, Ningwei Zhao, Hongshan Chen, Longxiyu Meng, Xinjian Li, Zhibin Hu, Xiaozhi Zhao, Hongqian Guo, Xu Qian. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00105-8

Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with SDHB gene mutation – Takao Kamai, Satoshi Murakami, Kyoko Arai, Daisaku Nishihara, Toshitaka Uematsu, Kazuyuki Ishida, Toshiki Kijima. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09415-5

Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells – Jin-Song Yan, Meng-Ying Yang, Xue-Hong Zhang, Chen-Hui Luo, Cheng-Kan Du, Yue Jiang, Xuan-Jia Dong, Zhang-Man Wang, Li-Xue Yang, Yi-Dong Li, Li Xia and Ying Lu. https://www.nature.com/articles/s41419-022-04842-5

PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer – Carmen Ghilardi, Catarina Moreira-Barbosa, Laura Brunelli, Paola Ostano, Nicolò Panini, Monica Lupi, Alessia Anastasia, Fabio Fiordaliso, Monica Salio, Laura Formenti, Massimo Russo, Edoardo Arrigoni, Ferdinando Chiaradonna, Giovanna Chiorino, Giulio Draetta, Joseph R. Marszalek, Christopher P. Vellano, Roberta Pastorelli, MariaRosa Bani, Alessandra Decio, Raffaella Giavazzi. https://aacrjournals.org/cancerres/article/82/7/1423/694053

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer – Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji. https://www.sciencedirect.com/science/article/pii/S2212877822000382


Starvation / AMPK


Carbon starvation, senescence and specific mitochondrial stresses, but not nitrogen starvation and general stresses, are major triggers for mitophagy in Arabidopsis – Sylwia M. Kacprzak and Olivier Van Aken. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2054039

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux – Qionghui Zhan, Jaepyo Jeon, Ying Li, Yu Huang, Jian Xiong, Qiaochu Wang, Tian-Le Xu, Yong Li, Fu-Hai Ji, Guangwei Du and Michael X Zhu. https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1954348

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis – Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00525-3


Hypoxia


NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment – Irene Bertolini, Michela Perego, Jagadish C. Ghosh, Andrew V. Kossenkov and Dario C. Altieri. https://www.nature.com/articles/s41388-022-02280-3

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation – Koh Nakayama, Sigal Shachar, Elizabeth H. Finn, Hiroyuki Sato, AkihiroHirakawa, and Tom Misteli. https://www.molbiolcell.org/doi/10.1091/mbc.E21-11-0593?ai=25zg&ui=2oy6&af=T

Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress – Sandhya Chipurupalli, Raja Ganesan, Giulia Martini, Luigi Mele, Alessio Reggio, Marianna Esposito, Elango Kannan, Vigneshwaran Namasivayam, Paolo Grumati, Vincenzo Desiderio and Nirmal Robinson. https://www.nature.com/articles/s41419-022-04813-w


Cancer Immunometabolism


Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer – Sarah A. Best, Patrick M. Gubser, Shalini Sethumadhavan,  Ariena Kersbergen., Yashira L. Negrón Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L. Garnham, Jackson A. McDonald, Clare E. Weeden, Dovile Anderson, David Pirman, Thomas P. Roddy, Darren J. Creek, Axel Kallies, Gillian Kingsbury, Kate D. Sutherland. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00130-9

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells – Jia Xiong, Jia He, Jun Zhu, Jiongli Pan, Weijie Liao, Hongying Ye, Haofei Wang, Yinjing Song, Yue Du, Bijun Cui, Maoguang Xue, Wanling Zheng, Xiangxing Kong, Kai Jiang, Kefeng Ding, Lihua Lai, Qingqing Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00207-6

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function – Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martín, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00127-9

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer – Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang. https://aacrjournals.org/cancerres/article-abstract/82/8/1575/694351

Metabolism drives macrophage heterogeneity in the tumor microenvironment – Shasha Li, Jiali Yu, Amanda Huber, Ilona Kryczek, Zhuwen Wang, Long Jiang, Xiong Li, Wan Du, Gaopeng Li, Shuang Wei, Linda Vatan, Wojciech Szeliga, Arul M. Chinnaiyan, Michael D. Green, Marcin Cieslik, Weiping Zou. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00357-6

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy – Lupeng Ye, Jonathan J. Park, Lei Peng, Quanjun Yang, Ryan D. Chow, Matthew B. Dong, Stanley Z. Lam, Jianjian Guo, Erting Tang, Yueqi Zhang, Guangchuan Wang, Xiaoyun Dai, Yaying Du, Hyunu R. Kim, Hanbing Cao, Youssef Errami, Paul Clark, Alexey Bersenev, Ruth R. Montgomery, Sidi Chen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00053-5

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 – Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou. https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00036-8


Glucose metabolism/lactate


Hexokinase 1 cellular localization regulates the metabolic fate of glucose – Adam De Jesus, Farnaz Keyhani-Nejad, Carolina M. Pusec, Lauren Goodman, Justin A. Geier, Joshua S. Stoolman, Paulina J. Stanczyk, Tivoli Nguyen, Kai Xu, Krishna V. Suresh, Yihan Chen, Arianne E. Rodriguez, Jason S. Shapiro, Hsiang-Chun Chang, Chunlei Chen, Kriti P. Shah, Issam Ben-Sahra, Brian T. Layden, Navdeep S. Chandel, Samuel E. Weinberg, Hossein Ardehali. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00166-6

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway – Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel. https://elifesciences.org/articles/69223

NEDD9 sustains hexokinase expression to promote glycolysis – Alexander Y. Deneka, Anna S. Nikonova, Hyung-Ok Lee, Warren D. Kruger and Erica A. Golemis. https://www.nature.com/articles/s41389-022-00391-w

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth – Chunwan Lu, Dafeng Yang, John D. Klement, Yolonda L. Colson, Nicholas H. Oberlies, Cedric J. Pearce, Aaron H. Colby, Mark W. Grinstaff, Zhuoqi Liu, Huidong Shi, Han-Fei Ding and Kebin Liu. https://www.nature.com/articles/s41388-022-02283-0

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis – Xuetian Yue, Jianming Wang, Chun-yuan Chang, Juan Liu, Xue Yang, Fan Zhou, Xia Qiu, Vrushank Bhatt, Jessie Yanxiang Guo, Xiaoyang Su, Lanjing Zhang, Zhaohui Feng and Wenwei Hu. https://www.nature.com/articles/s41419-022-04820-x

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells – Vivian Morris, Dahai Wang, Zhiheng Li, William Marion, Travis Hughes, Patricia Sousa, Taku Harada, Shannan Ho Sui, Sergey Naumenko, Jérémie Kalfon, Prerana Sensharma, Marcelo Falchetti, Renan Vinicius da Silva, Tito Candelli, Pauline Schneider, Thanasis Margaritis, Frank C.P. Holstege, Yana Pikman, Marian Harris, Ronald W. Stam, Stuart H. Orkin, Angela N. Koehler, Alex K. Shalek, Trista E. North, Maxim Pimkin, George Q. Daley, Edroaldo Lummertz da Rocha, R. Grant Rowe. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00516-2

A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma – Jennifer G. Gill, Samantha N. Leef, Vijayashree Ramesh, Misty S. Martin-Sandoval, Aparna D. Rao, Lindsey West, Sarah Muh, Wen Gu, Zhiyu Zhao, Gregory A. Hosler, Travis W. Vandergriff, Alison B. Durham, Thomas P. Mathews, Arin B. Aurora. https://aacrjournals.org/cancerres/article-abstract/82/7/1251/694035

A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer – Emanuela Dylgjeri, Vishal Kothari, Ayesha A. Shafi, Galina Semenova, Peter T. Gallagher, Yi F. Guan, Angel Pang, Jonathan F. Goodwin, Swati Irani, Jennifer J. McCann, Amy C. Mandigo, Saswati Chand, Christopher M. McNair, Irina Vasilevskaya, Matthew J. Schiewer, Costas D. Lallas,  Peter A. McCue, Leonard G. Gomella, Erin L. Seifert, Jason S. Carroll, Lisa M. Butler, Jeff Holst, William K. Kelly, Karen E. Knudsen. https://aacrjournals.org/clincancerres/article/28/7/1446/682199/

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability – Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante and Jan Jacob Schuringa. https://www.nature.com/articles/s41467-022-29639-0


Amino acid metabolism


MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis – Hamed Alborzinia, Andrés F. Flórez, Sina Kreth, Lena M. Brückner, Umut Yildiz, Moritz Gartlgruber, Dorett. Odoni, Gernot Poschet, Karolina Garbowicz, Chunxuan Shao, Corinna Klein, Jasmin Meier, Petra Zeisberger, Michal Nadler-Holly, Matthias Ziehm, Franziska Paul, Jürgen Burhenne, Emma Bell, Marjan Shaikhkarami, Roberto Würth, Sabine A. Stainczyk, Elisa M. Wecht, Jochen Kreth, Michael Büttner, Naveed Ishaque, Matthias Schlesner, Barbara Nicke, Carlo Stresemann, María Llamazares-Prada, Jan H. Reiling, Matthias Fischer, Ido Amit, Matthias Selbach, Carl Herrmann, Stefan Wölfl, Kai-Oliver Henrich, Thomas Höfer, Andreas Trumpp and Frank Westermann. https://www.nature.com/articles/s43018-022-00355-4

Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial – Funda Meric-Bernstam, Nizar M. Tannir, Othon Iliopoulos, Richard J. Lee, Melinda L. Telli, Alice C. Fan, Angela DeMichele, Naomi B. Haas, Manish R. Patel, James J. Harding, Martin H. Voss, Taofeek K. Owonikoko, Bradley Carthon, Ramaprasad Srinivasan, Johanna C. Bendell, Yonchu Jenkins, Sam H. Whiting, Keith Orford, Mark K. Bennett, Todd M. Bauer. https://aacrjournals.org/clincancerres/article-abstract/28/8/1540/694145

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy – Mario R. Fernandez, Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, rank C. Dorsey, Min Liu, Meredith A. Steeves, Andrea Ballabio, Alexandar Tzankov, Zhihua Chen, John M. Koomen, Anders E. Berglund, John L. Cleveland. https://aacrjournals.org/cancerres/article/82/7/1234/694032

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML – Chang Liu, Waiyi Zou, Danian Nie, Shuyi Li, Chen Duan, Min Zhou, Peilong Lai, Shengyong Yang, Sen Ji, Yangqiu Li, Mei Mei, Shilai Bao, Yanli Jin, Jingxuan Pan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00131-0

Characterization of metabolic alterations of Chronic Lymphocytic Leukemia in the lymph node microenvironment – Zhenghao Chen,  Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, Michel van Weeghel, Dean Bryant, Jaco A. C. van Bruggen, F. S. Peters, Jeffrey C. Rathmell, G.J.W. van der Windt, Arnon P Kater, Graham Packham, Eric Eldering. https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2021013990/485126


Miscellaneous


Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia – Elisabeth Wyart, Myriam Y Hsu, Roberta Sartori, Erica Mina, Valentina Rausch, Elisa S Pierobon, Mariarosa Mezzanotte, Camilla Pezzini, Laure B Bindels, Andrea Lauria, Fabio Penna, Emilio Hirsch, Miriam Martini, Massimiliano Mazzone, Antonella Roetto, Simonetta Geninatti Crich, Hans Prenen, Marco Sandri, Alessio Menga, Paolo E Porporato. https://www.embopress.org/doi/full/10.15252/embr.202153746

Integrative metabolomic characterization identifies plasma metabolomic signature in the diagnosis of papillary thyroid cancer – Shuang Yu, Changan Liu, Yingtong Hou, Jie Li, Zhuming Guo, Xinwen Chen, Luyao Zhang, Sui Peng, Shubin Hong, Lixia Xu, Xiaoxing Li, Rengyun Liu, Shuwei Chen, Bin Li, Zongpeng Weng, Yanbing Li, Weiming Lv, Jun Yu and Haipeng Xiao. https://www.nature.com/articles/s41388-022-02254-5

Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms – James R. Larkin, Susan Anthony, Vanessa A. Johanssen, Tianrong Yeo, Megan Sealey, Abi G. Yates, Claire Friedemann Smith, Timothy D.W. Claridge, Brian D. Nicholson, Julie-Ann Moreland, Fergus Gleeson, Nicola R. Sibson, Daniel C. Anthony, Fay Probert. https://aacrjournals.org/clincancerres/article/28/8/1651/694157

Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy – Marta Mascaraque-Checa, María Gallego-Rentero, Jimena Nicolás-Morala, Mikel Portillo-Esnaola, José M. Cuezva, Salvador González, Yolanda Gilaberte, Ángeles Juarranz. https://www.sciencedirect.com/science/article/pii/S2212877822000655

An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition – Maurizio Ragni, Chiara Ruocco, Laura Tedesco, Michele O.Carruba, Alessandra Valerio, Enzo Nisoli. https://www.sciencedirect.com/science/article/pii/S2212877822000473

Atg6 promotes organismal health by suppression of cell stress and inflammation – James L. Shen, Johnna Doherty, Elizabeth Allen, Tina M. Fortier and Eric H. Baehrecke. https://www.nature.com/articles/s41418-022-01014-y


Nucleotides and NADPH


Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity – Amy Tarangelo, Jason Rodencal, Joon Tae Kim, Leslie Magtanong, Jonathan Z Long and Scott J Dixon. https://www.life-science-alliance.org/content/5/4/e202101157.abstract

NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells – Chiqi Chen, Xiaoyun Lai, Yaping Zhang, Li Xie, Zhuo Yu, Sijia Dan, Yu Jiang, Weicai Chen, Ligen Liu, Yi Yang, Dan Huang, Yuzheng Zhao, Junke Zheng. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00355-2

MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers – Omar Alhalabi, Jianfeng Chen, …, and Jianjun Gao. https://www.nature.com/articles/s41467-022-29397-z


Reviews


The two sides of creatine in cancer – Liwen Zhang, Pengcheng Bu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00230-0

Regulation of chromatin accessibility by hypoxia and HIF – Michael Batie; Julianty Frost; Dilem Shakir; Sonia Rocha. https://portlandpress.com/biochemj/article/479/6/767/230989

Glutamine, MTOR and autophagy: a multiconnection relationship – Clément Bodineau, Mercedes Tomé, Piedad del Socorro Murdoch and Raúl V. Durán. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2062875

Emerging signaling mediators in the anorexia–cachexia syndrome of cancer – Erin E. Talbert, Denis C. Guttridge. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00010-3


Comments


Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival – Dohun Kim, Gerta Hoxhaj. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00375-6

Circling back to PTEN: Fumarate inhibits canonical tumor suppressor – Sally E. Claridge, Benjamin D. Hopkins. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00222-2

Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness – Emily J. Kay and Sara Zanivan. https://www.nature.com/articles/s42255-022-00540-w

Alternative cycle for citrate – Paulina Strzyz. https://www.nature.com/articles/s41580-022-00475-w

Restored Ketosis Drives Anticancer Immunity in Colorectal Cancer – David C. Montrose, Lorenzo Galluzzi. https://aacrjournals.org/cancerres/article-abstract/82/8/1464/694347

In an Era of ctDNA, Is Metabolomics the New Kid on the Block? – Brian A. Van Tine, Costas A. Lyssiotis. https://aacrjournals.org/clincancerres/article-abstract/28/8/1477/694166

Cell scientist to watch – Lydia Finley. https://journals.biologists.com/jcs/article/135/7/jcs260023/274953

Dying cell-derived SAM switches off inflammation – Roel P. H. De Maeyer and Derek W. Gilroy. https://www.nature.com/articles/s42255-022-00556-2

A FAsT contribution: Adipocytes rewire their metabolism to acquire immune functions – Takumi Kobayashi, Dirk Brenner. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00134-6?


Profile of Ana Maria Cuervo  – Sandeep Ravindran. https://www.pnas.org/doi/10.1073/pnas.2204524119?ai=aqle&ui=c8ih&af=T

MetaboList – March 2022


Glucose metabolism


A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine – Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi, Nadia Ducano, Alessia Mira, Manasvi S. Shah, Sylwia A. Stopka, Andrew J. Perciaccante, Claudio Isella, Daniel Moya-Rull, Marianela Vara-Messler, Silvia Giordano, Elena Maldi, Niyati Desai, Diane E. Capen, Enzo Medico, Murat Cetinbas, Ruslan I. Sadreyev, Dennis Brown, Miguel N. Rivera, Anna Sapino, David T. Breault, Nathalie Y. R. Agar and Raul Mostoslavsky. https://www.nature.com/articles/s41467-022-29085-y

MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer – Cannistraci, P. Hascoet, A. Ali, P. Mundra, N. W. Clarke, V. Pavet and R. Marais. https://www.nature.com/articles/s41388-022-02178-0

Aminopyridine analogs selectively target metastatic pancreatic cancer – Rana V. Smalling, Matthew E. Bechard, Jeff Duryea, Philip J. Kingsley, Evan R. Roberts, Lawrence J. Marnett, Daniel Bilbao, Shaun R. Stauffer and Oliver G. McDonald. https://www.nature.com/articles/s41388-022-02183-3

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma – Jia Li, Zhi-Qiang Hu, Song-Yang Yu, Li Mao; Zheng-Jun Zhou, Peng-Cheng Wang, Yu Gong; Sheng Su, Jian Zhou, Jia Fan, Shao-Lai Zhou, Xiao-Wu Huang. https://aacrjournals.org/cancerres/article-abstract/82/6/1055/682071


Amino acids


Tryptophan depletion results in tryptophan-to-phenylalanine substitutants – Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S. Peeper and Reuven Agami. https://www.nature.com/articles/s41586-022-04499-2

For more papers on glutamine metabolism follow https://twitter.com/sreeparna_b

http://biomed.news/bims-glucam/2022-03-06

http://biomed.news/bims-glucam/2022-03-20

http://biomed.news/bims-glucam/2022-03-13

http://biomed.news/bims-glucam/2022-03-27


Lipid metabolism / acetate


Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia – Marissa Rashkovan, Robert Albero, Francesca Gianni, Pablo Perez-Duran, Hannah I. Miller, Adam L. Mackey, Elisabeth M. Paietta, Martin S. Tallman, Jacob M. Rowe, Mark R. Litzow, Peter H. Wiernik, Selina Luger, Maria Luisa Sulis, Rajesh K. Soni, Adolfo A. Ferrando. https://aacrjournals.org/cancerdiscovery/article/12/3/856/681883

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation – Lorela Ciraku, Zachary A. Bacigalupa, Jing Ju, Rebecca A. Moeller, Giang Le Minh, Rusia H. Lee, Michael D. Smith, Christina M. Ferrer, Sophie Trefely, Luke T. Izzo, Mary T. Doan, Wiktoria A. Gocal, Luca D’Agostino, Wenyin Shi, Joshua G. Jackson, Christos D. Katsetos, Kathryn E. Wellen, Nathaniel W. Snyder and Mauricio J. Reginato. https://www.nature.com/articles/s41388-022-02237-6


Nucleotides


Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex – Sharon Spizzichino, Dalila Boi, Giovanna Boumis, Roberta Lucchi, Francesca Romana Liberati, Davide Capelli, Roberta Montanari, Giorgio Pochetti, Roberta Piacentini, Giacomo Parisi, Alessio Paone, Serena Rinaldo, Roberto Contestabile, Angela Tramonti, Alessandro Paiardini, Giorgio Giardina, Francesca Cutruzzolà. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16248


Mitochondria and iron


CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH – Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00226-1

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death – Sylvain Garciaz, Andrew A. Guirguis, Sebastian Müller, Fiona C. Brown, Yih-Chih Chan, Ali Motazedian, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y.N. Lam, Tatiana Cañeque, Marian L. Burr, Véronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C.S. Huang, Andrew H. Wei, Kate McArthur, Raphaël Rodriguez, Mark A. Dawson. https://aacrjournals.org/cancerdiscovery/article/12/3/774/681925

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma – Julie Devin, Tatiana Cañeque, Yea-Lih Lin, Lucie Mondoulet, Jean-Luc Veyrune, Matthieu Abouladze, Elvira Garcia De Paco, Ouissem Karmous Gadacha, Guillaume Cartron, Philippe Pasero, Caroline Bret, Raphaël Rodriguez, Jerome Moreaux. https://aacrjournals.org/cancerres/article/82/6/998/682058

Mitochondrial respiration supports autophagy to provide stress resistance during quiescence – Silvia Magalhaes-Novais, Jan Blecha, Ravindra Naraine, Jana Mikesova, Pavel Abaffy, Alena Pecinova, Mirko Milosevic, Romana Bohuslavova, Jan Prochazka, Shawez Khan, Eliska Novotna, Radek Sindelka, Radek Machan, Mieke Dewerchin, Erik Vlcak, Joanna Kalucka, Sona Stemberkova Hubackova, Ales Benda, Jermaine Goveia, Tomas Mracek, Cyril Barinka, Peter Carmeliet, Jiri Neuzil, Katerina Rohlenova and Jakub Rohlena. https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2038898

Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice – Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz-Barneo, G. R. Scott Budinger and Navdeep S. Chandel. https://www.nature.com/articles/s41598-022-09074-3


Starvation / nutrient sensing


Amino acid starvation‐induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance – Ye Chen, Xiao Wu, Jing Zhang, Guopin Pan, Xiaoyun Wang, Xiaosun Guo, Jianli Wang, Xiaopei Cui, Haiqing Gao, Mei Cheng, Jingwen Yang, Cheng Zhang, Fan Jiang. https://www.embopress.org/doi/full/10.15252/embr.202153373

Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation – Kamilla M. E. Laidlaw, Katherine M. Paine, Daniel D. Bisinski, Grant Calder, Karen Hogg, Sophia Ahmed, Sally James, Peter J. O’Toole, and Chris MacDonald. https://www.molbiolcell.org/doi/full/10.1091/mbc.E21-04-0163

Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer – Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao, Peng Gao. https://aacrjournals.org/cancerres/article-abstract/82/5/805/681782


Hypoxia


Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy – Jingyi Li, Tao Zhang, Tao Ren, Xiaoyu Liao, Yilong Hao, Je Sun Lim, Jong-Ho Lee, Mi Li, Jichun Shao and Rui Liu. https://www.nature.com/articles/s41467-022-28831-6


IDH


Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma – Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E. Olander, Ramzi Adil, Amaya Pankaj, Krishna Seshu Tummala, Vajira Weeresekara, Yuanli Zhen, Qibiao Wu, Meiqi Luo, William Shen, María García-Beccaria, Mirian Fernández-Vaquero, Christine Hudson, Sebastien Ronseaux, Yi Sun; Rodrigo Saad-Berreta, Russell W. Jenkins, Tong Wang, Mathias Heikenwälder, Cristina R. Ferrone, Lipika Goyal, Brandon Nicolay, Vikram Deshpande, Rahul M. Kohli, Hongwu Zheng, Robert T. Manguso, Nabeel Bardeesy. https://aacrjournals.org/cancerdiscovery/article/12/3/812/68192


Cancer Immunometabolism


Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses – Kunle Odunsi, Feng Qian, Amit A. Lugade, Han Yu, Melissa A. Geller, Steven P. Fling, Judith C. Kaiser, Andreanne M. Lacroix, Leonard D’Amico, Nirasha Ramchurren, Chihiro Morishima, Mary L. Disis, Lucas Dennis, Patrick Danaher, Sarah Warren, Van Anh Nguyen, Sudharshan Ravi, Takemasa Tsuji, Spencer Rosario, Wenjuan Zha, Alan Hutson, Song Liu, Shashikant Lele, Emese Zsiros, A. J. Robert McGray, Jessie Chiello, Richard Koya, Thinle Chodon, Carl D. Morrison, Vasanta Putluri, Nagireddy Putluri, Donald E. Mager, Rudiyanto Gunawan, Martin A. Cheever, Sebastiano Battaglia, Junko Matsuzaki. https://www.science.org/doi/abs/10.1126/scitranslmed.abg8402

Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma – Brooks P. Leitner, Kevin B. Givechian, Shyryn Ospanova, Aray Beisenbayeva, Katerina Politi and Rachel J. Perry. https://www.nature.com/articles/s41698-021-00248-2


Miscellaneous


Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis – Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras and Patricia Aspichueta. https://www.nature.com/articles/s41467-022-28749-z

Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer – Caner Yelek, Lionel Mignion, Adrien Paquot, Caroline Bouzin, Cyril Corbet, Giulio G Muccioli, Patrice D Cani, Bénédicte F Jordan. https://www.mdpi.com/2072-6694/14/3/562

Angiocrine polyamine production regulates adiposity – Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura Herrero, Rui Benedito, Pablo Garcia-Roves, Josep Vidal, Paul Cohen, Rubén Nogueiras, Marc Claret, Arkaitz Carracedo and Mariona Graupera. https://www.nature.com/articles/s42255-022-00544-6


Reviews


NRF2: KEAPing Tumors Protected – Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos. https://aacrjournals.org/cancerdiscovery/article/12/3/625/681905

Advancing Cancer Treatment by Targeting Glutamine Metabolism-A Roadmap – Anna Halama, Karsten Suhre. https://www.mdpi.com/2072-6694/14/3/553

Structural advances in sterol-sensing domain-containing proteins – Xuelan Wu, Renhong Yan, Pingping Cao, Hongwu Qian, Nieng Yan. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(21)00274-7

Insulin and cancer: a tangled web – Brooks P. Leitner, Stephan Siebel, Ngozi D. Akingbesote, Xinyi Zhang, Rachel J. Perry. https://portlandpress.com/biochemj/article/479/5/583/230979

The central moTOR of metabolism – Judith Simcox, Dudley W. Lamming. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00126-5


Comments


IDH1 Inhibition Reawakens the Immune Response against Cholangiocarcinoma – Yan Zhu, Lawrence N. Kwong. https://aacrjournals.org/cancerdiscovery/article/12/3/604/681915

MTHFD2, metabolic mastermind of CD4+ T cell destiny – Victoire Gouirand and Michael D. Rosenblum. https://www.science.org/doi/full/10.1126/sciimmunol.abo6765

Metabolic Adaptations Alter Metastatic Fitness in Brain-Tropic Breast Cancer. https://aacrjournals.org/cancerdiscovery/article/12/3/OF5/681892

CAR T-cell Efficacy in Solid Tumors Is Affected by N-glycosylation. https://aacrjournals.org/cancerdiscovery/article/12/3/598/681906

Obesity and antitumor immunity – John F. Foley. https://www.science.org/doi/full/10.1126/scisignal.abq0080

MetaboList – February 2022


Reviews


The hallmarks of cancer metabolism: Still emerging – Natalya N. Pavlova, Jiajun Zhu, Craig B. Thompson. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00022-5

Metabolic programs tailor T cell immunity in viral infection, cancer, and aging – Sofie Hedlund Møller, Pei-Chun Hsueh, Yi-Ru Yu, Lianjun Zhang, Ping-Chih Ho. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00047-X

Clinical development of metabolic inhibitors for oncology – Kathryn M Lemberg, Sadakatali S Gori, Takashi Tsukamoto, Rana Rais, Barbara S Slusher. https://www.jci.org/articles/view/148550

Diet, lipids, and antitumor immunity – Hannah Prendeville and Lydia Lynch. https://www.nature.com/articles/s41423-021-00781-x

Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling – Michael Batie, Niall S. Kenneth, Sonia Rocha. https://portlandpress.com/biochemj/article/479/3/245/230736

Persister cancer cells: Iron addiction and vulnerability to ferroptosis – Raphaël Rodriguez, Stuart L. Schreiber, Marcus Conrad. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01038-8

Interleukin 6 as an energy allocator in muscle tissue – Timothy M. Kistner, Bente K. Pedersen and Daniel E. Lieberman. https://www.nature.com/articles/s42255-022-00538-4


Starvation/metformin


Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting – Patrick Jouandin, Zvonimir Marelja, Yung-Hsin Shih, Andrey A. Parkhitko, Miriam Dambowsky, John M. Asara, Ivan Nemazanyy, Christian C. Dibble, Matias Simons, Norbert Perrimon. https://www.science.org/doi/abs/10.1126/science.abc4203

Low-dose metformin targets the lysosomal AMPK pathway through PEN2 – Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin. https://www.nature.com/articles/s41586-022-04431-8

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis – Traci E. LaMoia,  Gina M. Butrico,  Hasini A. Kalpage,  Leigh Goedeke,  Brandon T. Hubbard,  Daniel F. Vatner,  Rafael C. Gaspar,  Xian-Man Zhang,  Gary W. Cline, Keita Nakahara, Seungwan Woo,  Atsuhiro Shimada,  Maik Hüttemann and Gerald I. Shulman. https://www.pnas.org/doi/10.1073/pnas.2122287119

An AMPKα2-specific phospho-switch controls lysosomal targeting for activation – Kaitlin R. Morrison, William J. Smiles, Naomi X.Y. Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin R.W. Ngoei, Dingyi Yu, Lisa Murray-Segal, John W. Scott, Sandra Galic, Bruce.E. Kemp, Janni Petersen, Jonathan S. Oakhill. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00086-9

SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence – J Ignacio Gutierrez, Gregory P Brittingham, Yonca B Karadeniz, Kathleen D Tran, Arnob Dutta, Alex S Holehouse, Craig L Peterson, Liam J Holt. https://elifesciences.org/articles/70344


Macropinocytosis


GCN2 adapts protein synthesis to scavenging-dependent growth – Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Li, Seunghun Han, Lance Parsons, Alexander N. Frese, Zemer Gitai, Tracy G. Anthony, Martin Wühr, David M. Sabatini, Joshua D. Rabinowitz. https://www.cell.com/cell-systems/fulltext/S2405-4712(21)00382-3

A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma – Yi-Fan Zhang, Qing Li, Pei-Qi Huang, Tong Su, Shu-Heng Jiang, Li-Peng Hu, Xue-Li Zhang, Yue Sun, Hong Pan, Xiao-Mei Yang, Jun Li, Yan-Zhi Gai, Lei Zhu, Lin-Li Yao, Dong-Xue Li, Yong-Wei Sun, Zhi-Gang Zhang, De-Jun Liu, Yan-Li Zhang and Hui-Zhen Nie. https://www.cell.com/cell-systems/fulltext/S2405-4712(21)00382-3

Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer – Misty Shuo Zhang, Jane Di Cui, Derek Lee, Vincent Wai-Hin Yuen, David Kung-Chun Chiu, Chi Ching Goh, Jacinth Wing-Sum Cheu, Aki Pui-Wah Tse, Macus Hao-Ran Bao, Bowie Po Yee Wong, Carrie Yiling Chen, Chun-Ming Wong, Irene Oi-Lin Ng and Carmen Chak-Lui Wong. https://www.nature.com/articles/s41467-022-28618-9


Pentose phosphate/glucosamines


Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival – Jessica Whitburn, Srinivasa R. Rao, Emma V. Morris, Sho Tabata, Akiyoshi Hirayama, Tomoyoshi Soga, James R. Edwards, Zeynep Kaya, Charlotte Palmer, Freddie C. Hamdy, Claire M. Edwards. https://www.science.org/doi/full/10.1126/sciadv.abf9096

Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition – Nicola Facchinello, Matteo Astone, Matteo Audano, Roxana E. Oberkersch, Marianna Spizzotin, Enrica Calura, Madalena Marques, Mihaela Crisan, Nico Mitro and Massimo M. Santoro. https://www.nature.com/articles/s42255-021-00514-4

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells – Arin B. Aurora, Vishal Khivansara, Ashley Leach, Jennifer G. Gill, Misty Martin-Sandoval, Chendong Yang, Stacy Y. Kasitinon, Divya Bezwada, Alpaslan Tasdogan, Wen Gu, Thomas P. Mathews, Zhiyu Zhao, Ralph J. DeBerardinis, and Sean J. Morrison. https://www.pnas.org/content/119/6/e2120617119.abstract?etoc

The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity – Jinguan Lin, Longzheng Xia, Linda Oyang, Jiaxin Liang, Shiming Tan, Nayiyuan Wu, Pin Yi, Qing Pan, Shan Rao, Yaqian Han, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Xiaohui Chen, Lixia Yang, Yujuan Zhou and Qianjin Liao. https://www.nature.com/articles/s41388-021-02148-y

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway – Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel. https://elifesciences.org/articles/69223


Glucose metabolism


Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells – Jason Godfrey, Romain Riscal, Nicolas Skuli and M. Celeste Simon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00280-1

PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis – Yu He, Xixi Wang, Weiliang Lu, Dan Zhang, Lan Huang, Yang Luo, Li Xiong, Haocheng Li, Peng Zhang, Qiu Li and Shufang Liang. https://www.nature.com/articles/s41419-022-04576-4

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1 – Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang, Yanping Xu, and Lei Lv. https://www.pnas.org/doi/10.1073/pnas.2114851119

PKM2 Is Essential for Bladder Cancer Growth and Maintenance – Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-Shong Tang, Tung-Tien Sun, Xue-Ru Wu. https://aacrjournals.org/cancerres/article/82/4/571/678084

Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy – Adviti Naik, Julie Decock. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13024

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma – Anna Han, Vivian Chua, Usman Baqai, Timothy J. Purwin, Nelisa Bechtel, Emily Hunter, Manoela Tiago, Erin Seifert, David W. Speicher, Zachary T. Schug, J. William Harbour and Andrew E. Aplin. https://www.nature.com/articles/s41388-021-02154-0

A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis – Catherine S. Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Soeun Kang, Prashanth Bhaskar, Alexander R. Terry, Alexandre F. Aissa, Maxim V. Frolov, Krushna C. Patra, R. Brooks Robey and Nissim Hay. https://www.nature.com/articles/s41467-022-28440-3


Amino acids


Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells – Saif Sattar Alaqbi, Lynsey Burke, Inna Guterman, Caleb Green, Kevin West, Raquel Palacios-Gallego, Hong Cai, Constantinos Alexandrou, Ni Ni Moe Myint,E mma Parrott,Lynne M. Howells, Jennifer A. Higgins, Donald J. L. Jones, Rajinder Singh, Robert G. Britton, Cristina Tufarelli, Anne Thomas, Alessandro Rufini. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262364

Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer – Lingfan Xu, Bing Zhao, William Butler, Huan Xu, Nan Song, Xufeng Chen, J. Spencer Hauck, Xia Gao, Hong Zhang, Jeff Groth, Qing Yang, Yue Zhao, David Moon, Daniel George, Yinglu Zhou, Yiping He and Jiaoti Huang. https://www.nature.com/articles/s41388-021-02155-z

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer – Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Sonia Fernandez-Ruiz, Cristina Viera, Onintza Carlevaris, Amaia Ercilla, Isabel Mendizabal, Teresa Martin, Alice Macchia, Laura Camacho, Mikel Pujana-Vaquerizo, Pilar Sanchez-Mosquera, Verónica Torrano, Natalia Martin-Martin, Patricia Zuniga-Garcia, Mireia Castillo-Martin, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Miguel Unda, Jose M. Mato, Edurne Berra, Maria L. Martinez-Chantar and Arkaitz Carracedo. https://www.nature.com/articles/s41389-022-00382-x

Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth – Jiang-Sha Zhao, Shuo Shi, Hai-Yan Qu, Zuzana Keckesova, Zi-Jian Cao, Li-Xian Yang, Xiaofu Yu, Limin Feng, Zhong Shi, Joanna Krakowiak, Ruo-Ying Mao, Yi-Tong Shen, Yu-Meng Fan, Tian-Min Fu, Cunqi Ye, Daqian Xu, Xiaofei Gao, Jia You, Wenbo Li, Tingbo Liang, Zhimin Lu and Yu-Xiong Feng. https://www.nature.com/articles/s42255-021-00524-2


Folate/Nucleotides


Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress – Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson et al. and Thomas Helleday. https://www.nature.com/articles/s43018-022-00331-y

Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma – Caitlin M. O’Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla. https://aacrjournals.org/cancerres/article/82/4/721/678077


Mitochondria / lipids


Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability – Jagadish C. Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R. Goldman, Hsin-Yao Tang, Andrew V. Kossenkov, Catherine J. Libby, Lucia R. Languino, Edward F. Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W. Speicher, M. Cecilia Caino, Joel Cassel, Joseph M. Salvino, Marie E. Robert, Valentina Vaira, and Dario C. Altieri. https://www.pnas.org/doi/10.1073/pnas.2115624119

Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas – Evelyn de Groot, Sruthy Varghese, Lin Tan, Barbara Knighton, Mary Sobieski, Nghi Nguyen, Yong Sung Park, Reid Powell, Philip L. Lorenzi, Bin Zheng, Clifford Stephan and Y. N. Vashisht Gopal. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00281-0

Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate – Mengjia Zhao, Pengbo Yao, Youxiang Mao, Jinjun Wu , Weihua Wang, Chenhui Geng, Jie Cheng, Wenjing Du and Peng Jiang. https://www.nature.com/articles/s42255-022-00532-w

SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA – Hezhi Fang, Anran Xie, Miaomiao Du, Xueyun Li, Kaiqiang Yang, Yinxu Fu, Xiangshu Yuan, Runxiao Fan, Weidong Yu, Zhuohua Zhou, Tiantian Sang, Ke Nie, Jin Li, Qiongya Zhao, Zhehui Chen, Yanling Yang, Chaoyang Hong, Jianxin Lyu. https://www.science.org/doi/abs/10.1126/scitranslmed.abl6992

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis – Sampath Katakam,  eSantosh Anand, Patricia Martin, Nicolo Riggi, Ivan Stamenkovic. https://www.life-science-alliance.org/content/5/3/e202101256.abstract?etoc


Cancer Immunometabolism


Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments – Shogo Kumagai, Shohei Koyama, Kota Itahashi, Tokiyoshi Tanegashima, Yi-tzu Lin, Yosuke Togashi, Takahiro Kamada, Takuma Irie, Genki Okumura, Hidetoshi Kono, Daisuke Ito, Rika Fujii, Sho Watanabe, Atsuo Sai, Shota Fukuoka, Eri Sugiyama, Go Watanabe, Takuya Owari, Hitomi Nishinakamura, Daisuke Sugiyama, Yuka Maeda, Akihito Kawazoe, Hiroki Yukami, Keigo Chida, Yuuki Ohara, Tatsuya Yoshida, Yuki Shinno, Yuki Takeyasu, Masayuki Shirasawa, Kenta Nakama, Keiju Aokage, Jun Suzuki, Genichiro Ishii, Takeshi Kuwata, Naoya Sakamoto, Masahito Kawazu, Toshihide Ueno, Taisuke Mori, Naoya Yamazaki, Masahiro Tsuboi, Yasushi Yatabe, Takahiro Kinoshita, Toshihiko Doi, Kohei Shitara, Hiroyuki Mano, Hiroyoshi Nishikawa. https://www.sciencedirect.com/science/article/pii/S1535610822000034

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression – De Huang, Yan Wang, J. Will Thompson, Tao Yin, Peter B. Alexander, Diyuan Qin, Poorva Mudgal, Haiyang Wu, Yaosi Liang, Lianmei Tan, Christopher Pan, Lifeng Yuan, Ying Wan, Qi-Jing Li and Xiao-Fan Wang. https://www.nature.com/articles/s41556-021-00820-9

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity – Kebria Hezaveh, Rahul S. Shinde, Andreas Klötgen, Marie Jo Halaby, Sara Lamorte, M. Teresa Ciudad, Rene Quevedo, Luke Neufeld, Zhe Qi Liu, Robbie Jin, Barbara T. Grünwald, Elisabeth G. Foerster, Danica Chaharlangi, Mengdi Guo, Priya Makhijani, Xin Zhang, Trevor J. Pugh, Devanand M. Pinto, Ileana L. Co, Alison P. McGuigan, Gun Ho Jang, Rama Khokha, Pamela S. Ohashi, Grainne M. O’Kane, Steven Gallinger, William W. Navarre, Heather Maughan, Dana J. Philpott, David G. Brooks, Tracy L. McGaha. https://www.cell.com/immunity/fulltext/S1074-7613(22)00035-8


Miscellaneous


Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer – Zuen Ren, Huizhi Liang, Phillip M. Galbo Jr, Malindrie Dharmaratne, Ameya S. Kulkarni, Atefeh Taherian Fard, Marie Louise Aoun, Nuria Martinez-Lopez, Kimita Suyama, Outhiriaradjou Benard, Wei Zheng, Yang Liu, Joseph Albanese, Deyou Zheng, Jessica C. Mar, Rajat Singh, Michael B. Prystowsky, Larry Norton, and Rachel B. Hazan. https://www.pnas.org/doi/10.1073/pnas.2107266119

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers – Chengheng Liao; Cherise Ryan Glodowski; Cheng Fan; Juan Liu; Kevin R. Mott; Akash Kaushik; Hieu Vu; Jason W. Locasale; Samuel K. McBrayer; Ralph J. DeBerardinis; Charles M. Perou; Qing Zhang. https://aacrjournals.org/cancerres/article/82/4/665/678072

SOX2 mediates metabolic reprogramming of prostate cancer cells – Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth A. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz and Donald J. Vander Griend. https://www.nature.com/articles/s41388-021-02157-x

Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis – Hitomi Yamamoto-Imoto, Satoshi Minami, Tatsuya Shioda, Yurina Yamashita, Shinsuke Sakai, Shihomi Maeda, Takeshi Yamamoto, Shinya Oki, Mizuki Takashima, Tadashi Yamamuro, Kyosuke Yanagawa, Ryuya Edahiro, Miki Iwatani, Mizue So, Ayaka Tokumura, Toyofumi Abe, Ryoichi Imamura, Norio Nonomura, Yukinori Okada, Donald E. Ayer, Hidesato Ogawa, Eiji Hara, Yoshitsugu Takabatake, Yoshitaka Isaka, Shuhei Nakamura, Tamotsu Yoshimori. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00171-1

Label-free sensing of cells with fluorescence lifetime imaging: The quest for metabolic heterogeneity – Evgeny A. Shirshin, Marina V. Shirmanova, Alexey V. Gayer, Maria M. Lukina, Elena E. Nikonova, Boris P. Yakimov, Gleb S. Budylin, Varvara V. Dudenkova, Nadezhda I. Ignatova, Dmitry V. Komarov, Vladislav V. Yakovlev, Wolfgang Becker, Elena V. Zagaynova, Vladislav I. Shcheslavskiy and Marlan O. Scully. https://www.pnas.org/doi/10.1073/pnas.2118241119

Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX – Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris and Jaromir Pastorek. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00279-8


Comments


Rag GTPases regulate cellular amino acid homeostasis – Ken Inoki and Kun-Liang Guan. https://www.pnas.org/doi/10.1073/pnas.2200788119

Immune sensing of microbial metabolites: Action at the tumor – Timothy L. Frankel, Marina Pasca di Magliano. https://www.cell.com/immunity/fulltext/S1074-7613(22)00038-3

Beating cancer one carbon at a time – Vasilis S. Dionellis and Thanos D. Halazonetis. https://www.nature.com/articles/s43018-022-00333-w

MetaboList – January 2022


Glucose metabolism


The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis – Youming Zhu, Lei Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00997-7

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1 – Tong Zhang, Linchong Sun, Yijie Hao, Caixia Suo, Shengqi Shen, Haoran Wei, Wenhao Ma, Pinggen Zhang, Ting Wang, Xuemei Gu, Shi-Ting Li, Zhaolin Chen, Ronghui Yan, Yi Zhang, Yongping Cai, Rongbin Zhou, Weidong Jia, Fang Huang, Ping Gao and Huafeng Zhang. https://www.nature.com/articles/s43018-021-00299-1

Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer – Nikita Sushentsev, Mary A. McLean and Ferdia A. Gallagher. https://www.nature.com/articles/s41467-022-28069-2

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells – Arin B. Aurora, Vishal Khivansara, Ashley Leach, Jennifer G. Gill, Misty Martin-Sandoval, Chendong Yang, Stacy Y. Kasitinon, Divya Bezwada, Alpaslan Tasdogan, Wen Gu, Thomas P. Mathews, Zhiyu Zhao, Ralph J. DeBerardinis, and Sean J. Morrison. https://www.pnas.org/content/119/6/e2120617119


Amino acids


Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors – Bo-Hyun Choi, Vipin Rawat, Jenny Högström, Philippa A. Burns, Kelly O. Conger, Mete Emir Ozgurses, Jaymin M. Patel, Tejas S. Mehta, Angelica Warren, Laura M. Selfors, Taru Muranen, Jonathan L. Coloff. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01793-9

Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions – Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00031-6


Lipids and cancer


Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity – Yanping Wang, Sungyong You, Shengchen Su, Austin Yeon, Eric M. Lo, Sungjin Kim, James L. Mohler, Michael R. Freeman and Hyung L. Kim. https://clincancerres.aacrjournals.org/content/28/2/414

MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation – Ting Zhang, Yanan Zhang, Jie Liu, Yan Ma, Qinong Ye, Xinlong Yan and Lihua Ding. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00276-3

C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer – Xiao-Zheng Liu, Anastasiia Rulina and Nils Halberg. https://www.nature.com/articles/s41467-021-27734-2

Lipidomic profiling of human serum enables detection of pancreatic cancer – Denise Wolrab, Robert Jirásko, Eva Cífková, Marcus Höring, Ding Mei, Michaela Chocholoušková, Ondřej Peterka, Jakub Idkowiak, Tereza Hrnčiarová, Ladislav Kuchař, Robert Ahrends, Radana Brumarová, David Friedecký, Gabriel Vivo-Truyols, Pavel Škrha, Jan Škrha, Radek Kučera, Bohuslav Melichar, Gerhard Liebisch, Ralph Burkhardt, Markus R. Wenk, Amaury Cazenave-Gassiot, Petr Karásek, Ivo Novotný, Kristína Greplová, Roman Hrstka and Michal Holčapek. https://www.nature.com/articles/s41467-021-27765-9

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis – Guangxi Wang, Mantang Qiu, Xudong Xing, Juntuo Zhou, Hantao Yao, Mingru Li, Rong Yin, Yan Hou, Yang Li, Shuli Pan, Yuqing Huang, Fan Yang, Fan Bai, Honggang Nie, Shuangshuang Di, Limei Guo, Zhu Meng, Jun Wang, Yuxin Yin. https://www.science.org/doi/abs/10.1126/scitranslmed.abk2756


Nucleotides


Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance – Gabriel Therizols, Zeina Bash-Imam, Baptiste Panthu, Christelle Machon, Anne Vincent, Julie Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, Maxime Garcia, Florian Laforêts, Virginie Marcel, Jihane Boubaker-Vitre, Marie-Ambre Monet, Céline Bouclier, Christophe Vanbelle, Guillaume Souahlia, Elise Berthel, Marie Alexandra Albaret, Hichem C. Mertani, Michel Prudhomme, Martin Bertrand, Alexandre David, Jean-Christophe Saurin, Philippe Bouvet, Eric Rivals, Théophile Ohlmann, Jérôme Guitton, Nicole Dalla Venezia, Julie Pannequin, Frédéric Catez and Jean-Jacques Diaz. https://www.nature.com/articles/s41467-021-27847-8


Mitochondria


Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism – Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex von Kriegsheim, Christian Frezza. https://elifesciences.org/articles/72593

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases – Esther P. Jane, Daniel R. Premkumar, Dhivyaa Rajasundaram, Swetha Thambireddy, Matthew C. Reslink, Sameer Agnihotri, Ian F. Pollack. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13025


Starvation


Leucine retention in lysosomes is regulated by starvation – Urmi Bandyopadhyay, Pavlina Todorova, Natalya N. Pavlova, Yuma Tada, Craig B. Thompson, Lydia W.S. Finley, and Michael Overholtzer. https://www.pnas.org/content/119/6/e2114912119

Endosomal cargo recycling mediated by Gpa1 and  Phosphatidylinositol-3-Kinase is inhibited by glucose starvation – Kamilla ME. Laidlaw, Katherine M. Paine, Daniel D. Bisinski, Grant Calder, Karen Hogg, Sophia Ahmed, Sally James, Peter J. O’Toole, and Chris MacDonald. https://www.molbiolcell.org/doi/10.1091/mbc.E21-04-0163?ai=25zg&ui=2oy6&af=T

The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress – Luyun Zou, Helen E Collins, Martin E Young, Jianhua Zhang, Adam R Wende, Victor M Darley-Usmar, John C Chatham.. https://www.frontiersin.org/articles/10.3389/fmolb.2021.780865/full


Hypoxia


Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions – Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00031-6

Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity – Brijesh Kumar, Adedeji K. Adebayo, Mayuri Prasad, Maegan L. Capitano, Ruizhong Wang, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Edward Simpson, Duojiao Chen, Yunlong Liu, Jeanne M. Schilder, Austyn B. Colter, Callista Maguire, Constance J. Temm, George Sandusky, Emma H. Doud, Aruna B. Wijeratne, Amber L. Mosley, Hal E. Broxmeyer, Harikrishna Nakshatri. https://www.science.org/doi/full/10.1126/sciadv.abh3375

Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers – Jialing Shen, Chunxue Yang, Misty Shuo Zhang, Don Wai-Ching Chin, For-Fan Chan, Cheuk-Ting Law, Gengchao Wang, Carol Lai-Hung Cheng, Mengnuo Chen, Rebecca Ting-Chi Wan, Mengjie Wu, Zhijian Kuang, Rakesh Sharma, Terence Kin Wah Lee, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00016-X


Cancer Immunometabolism


MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function – Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, Katherine L. Beier, Nowrin U. Chowdhury, Melissa M. Wolf, Arissa C. Young, Dalton L. Greenwood, Allison E. Sewell, Shailesh K. Shahi, Samantha N. Freedman, Alanna M. Cameron, Patrik Foerch, Tim Bourne, Juan C. Garcia-Canaveras, John Karijolich, Dawn C. Newcomb, Ashutosh K. Mangalam, Joshua D. Rabinowitz, Jeffrey C. Rathmell. https://www.cell.com/immunity/fulltext/S1074-7613(21)00448-9

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function – Lydia Dyck,  Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk, Roisin M. Loftus, Aaron Douglas, Janet McCormack, Bruce Moran, Michael Wilkinson, Evanna L. Mills, Michael Doughty, Aurelie Fabre, Helen Heneghan, Carel LeRoux, Andrew Hogan, Edward T. Chouchani, Donal O’Shea, Donal Brennan, Lydia Lynch. https://rupress.org/jem/article/219/3/e20210042/212992


Fasting


Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer – Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimondi, Darawan Rinchai, Gianmaria Frigè, Antonino Belfiore, Luca Lalli, Claudia Chiodoni, Valeria Cancila, Federica Zanardi, Arta Ajazi, Salvatore Cortellino, Viviana Vallacchi, Paola Squarcina, Agata Cova, Samantha Pesce, Paola Frati, Raghvendra Mall, Paola Antonia Corsetto, Angela Maria Rizzo, Cristina Ferraris, Secondo Folli, Marina Chiara Garassino, Giuseppe Capri, Giulia Bianchi, Mario Paolo Colombo, Saverio Minucci, Marco Foiani, Valter Daniel Longo, Giovanni Apolone, Valter Torri, Giancarlo Pruneri, Davide Bedognetti, Licia Rivoltini and Filippo de Braud. https://cancerdiscovery.aacrjournals.org/content/12/1/90

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism – Jelena Krstic, Isabel Reinisch, Katharina Schindlmaier, Markus Galhuber, Zina Riahi, Natascha Berger, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Helene Michenthaler, Christoph Nössing, Maria R. Depaoli, Jeta Ramadani-Muja, Sinem Usluer, Sarah Stryeck, Martin Pichler, Beate Rinner, Alexander J. A. Deutsch, Andreas Reinisch, Tobias Madl, Riccardo Zenezini Chiozzi, Albert J. R. Heck, Meritxell Huch, Roland Malli, Andreas Prokesch. https://www.science.org/doi/full/10.1126/sciadv.abh2635


Miscellaneous


Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors – Rupsa Datta, Sharanya Sivanand, Allison N. Lau, Logan V. Florek, Anna M. Barbeau, Jeffrey Wyckoff, Melissa C. Skala, Matthew G. Vander Heiden. https://www.science.org/doi/full/10.1126/sciadv.abg6383

Mitochondria shed their outer membrane in response to infection-induced stress – Xianhe Li, Julian Straub, Tânia Catarina Medeiros, Chahat Mehra, Fabian den Brave, Esra Peker, Ilian Atanassov, Katharina Stillger, Jonas Benjamin Michaelis, Emma Burbridge, Colin Adrain, Christian Münch, Jan Riemer, Thomas Becker, Lena F. Pernas. https://www.science.org/doi/abs/10.1126/science.abi4343


Reviews


Hypoxia-Inducible Factors in Cancer – Laura C. Kim, and M. Celeste Simon. https://cancerres.aacrjournals.org/content/82/2/195

Understanding the role of cysteine in ferroptosis: progress & paradoxes – Carson D. Poltorack, Scott J. Dixon. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15842

Amino Acid Metabolism in Cancer Drug Resistance – Hee-Chan Yoo and Jung-Min Han. https://doi.org/10.3390/cells11010140

Metabolic adaptation of lymphocytes in immunity and disease – Nicole M. Chapman, Hongbo Chi. https://www.cell.com/immunity/fulltext/S1074-7613(21)00548-3

The assembly, regulation and function of the mitochondrial respiratory chain – Irene Vercellino & Leonid A. Sazanov. https://www.nature.com/articles/s41580-021-00415-0

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma – Gabriel Alzial, Ophelie Renoult, François Paris, Catherine Gratas, Anne Clavreul and Claire Pecqueur. https://www.nature.com/articles/s41388-021-02056-1

Circulating metabolite homeostasis achieved through mass action – Xiaoxuan Li, Sheng Hui, Emily T. Mirek, William O. Jonsson, Tracy G. Anthony, Won Dong Lee, Xianfeng Zeng, Cholsoon Jang and Joshua D. Rabinowitz. https://www.nature.com/articles/s42255-021-00517-1

Built to last: lysosome remodeling and repair in health and disease – Roberto Zoncu, Rushika M.Perera. https://www.sciencedirect.com/science/article/pii/S0962892422000010

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap – Anna Halama and Karsten Suhre. https://www.mdpi.com/2072-6694/14/3/553

Cellular senescence: all roads lead to mitochondria – Hélène Martini, João F. Passos. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16361#.Yfhngl2bq4U


Comments


Metabolic transitions – Anna Dart. https://www.nature.com/articles/s41568-021-00438-x

Shifting acetylation during starvation – Wei Wong. https://www.science.org/doi/full/10.1126/scisignal.abo1065

Pentose phosphate pathway drives vascular maturation – Olga A. Cherepanova and Tatiana V. Byzova. https://www.nature.com/articles/s42255-021-00512-6

Tumor-Secreted Lipids Induce ER Stress Response to Polarize Macrophageshttps://cancerdiscovery.aacrjournals.org/content/12/1/OF5