MetaboList – October 2020


Amino acid metabolism


Serine restriction alters sphingolipid diversity to constrain tumour growth – Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani Gengatharan, Antonio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace, Alan Saghatelian and Christian M. Metallo. https://www.nature.com/articles/s41586-020-2609-x

Polyamine pathway activity promotes cysteine essentiality in cancer cells – Tong Zhang, Christin Bauer, Alice C. Newman, Alejandro Huerta Uribe, Dimitris Athineos, Karen Blyth and Oliver D. K. Maddocks. https://www.nature.com/articles/s42255-020-0253-2

Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells – Rohiverth Guarecuco , Robert T. Williams, Lou Baudrier, Konnor La, Maria C. Passarelli, Naz Ekizoglu, Mert Mestanoglu, Hanan Alwaseem, Bety Rostandy, Justine Fidelin, Javier Garcia-Bermudez, Henrik Molina, Kivanç Birsoy. https://advances.sciencemag.org/content/6/41/eabc7120

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer – Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards. https://elifesciences.org/articles/56749

Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers – Yao-An Shen, Jiaxin Hong, Ryoichi Asaka, Shiho Asaka, Fang-Chi Hsu, Yohan Suryo Rahmanto, Jin-Gyoung Jung, Yu-Wei Chen, Ting-Tai Yen, Alicja Tomaszewski, Cissy Zhang, Nabeel Attarwala, Angelo M. DeMarzo, Ben Davidson, Chi-Mu Chuang, Xi Chen, Stephanie Gaillard, Anne Le, Ie-Ming Shih and Tian-Li Wang. https://cancerres.aacrjournals.org/content/80/20/4514

Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting – Hawley E Kunz, Jessica M Dorschner, Taylor E Berent, Thomas Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar and Ian R. Lanza. http://www.jbc.org/content/early/2020/10/01/jbc.RA120.014884.abstract


Glucose metabolism


Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle – Shiyu Liu, Ziwei Dai, Daniel E Cooper, David G Kirsch, Jason W Locasale. https://www.sciencedirect.com/science/article/abs/pii/S1550413120304836

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma – Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31282-1

Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation – Suparno Nandi, Mortezaali Razzaghi, Dhiraj Srivastava and Mishtu Dey. http://www.jbc.org/content/early/2020/09/28/jbc.RA120.015800.abstract

Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer – Bei Li, Qian Yang, Zhiyu Li, Zhiliang Xu, Si Sun, Qi Wu, and Shengrong Sun. https://www.frontiersin.org/articles/10.3389/fonc.2020.574787/full

Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer – Jiyoung Kim, Jengmin Kang, Ye-Lim Kang, Jongmin Woo, Youngsoo Kim, June Huh and Jong-Wan Park. https://www.nature.com/articles/s41467-020-19263-1


Lipid metabolism


Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase – Angela Maria Savino, Sara Isabel Fernandes, Orianne Olivares, Anna Zemlyansky, Antony Cousins, Elke K. Markert, Shani Barel, Ifat Geron, Liron Frishman, Yehudit Birger, Cornelia Eckert, Sergey Tumanov, Gillian MacKay, Jurre J. Kamphorst, Pawel Herzyk, Jonatan Fernández-García, Ifat Abramovich, Inbal Mor, Michela Bardini, Ersilia Barin, Sudha Janaki-Raman, Justin R. Cross, Michael G. Kharas, Eyal Gottlieb, Shai Izraeli and Christina Halsey. https://www.nature.com/articles/s43018-020-00115-2

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer – Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri, Janusz Franco-Barraza, Diana Restifo, Nicole Weitz, Charline Ogier, Aaron R. Goldman, Tiffiney R. Hartman, Ralph Francescone, Yinfei Tan, Emmanuelle Nicolas, Neelima Shah, Elizabeth A. Handorf, Kathy Q. Cai, Alana M. O’Reilly, Ido Sloma, Rachel Chiaverelli, Richard A. Moffitt, Vladimir Khazak, Carolyn Y. Fang, Erica A. Golemis, Edna Cukierman, Igor Astsaturov. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30426-8

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype – Virginia Lope, Ángel Guerrero-Zotano, Ana Casas, José Manuel Baena-Cañada, Begoña Bermejo, Beatriz Pérez-Gómez, Inmaculada Criado-Navarro, Silvia Antolín, Pedro Sánchez-Rovira, Manuel Ramos-Vázquez, Antonio Antón, Adela Castelló, José Ángel García-Saénz, Montserrat Muñoz, Ana de Juan, Raquel Andrés, Antonio Llombart-Cussac, Blanca Hernando, Rosa María Franquesa, Rosalia Caballero, Feliciano Priego-Capote, Miguel Martín and Marina Pollán. https://www.mdpi.com/2072-6643/12/10/3132

Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem–Like Cells and Reduces Metastases through Effects on Lipid Anabolism – Rosanna Dattilo, Carla Mottini, Emanuela Camera, Alessia Lamolinara, Noam Auslander, Ginevra Doglioni, Michela Muscolini, Wei Tang, Melanie Planque, Cristiana Ercolani, Simonetta Buglioni, Isabella Manni, Daniela Trisciuoglio, Alessandra Boe, Sveva Grande, Anna Maria Luciani, Manuela Iezzi, Gennaro Ciliberto, Stefan Ambs, Ruggero De Maria, Sarah-Maria Fendt, Eytan Ruppin and Luca Cardone. https://cancerres.aacrjournals.org/content/80/19/4087


Mitochondria and nucleotides


MCART1/SLC25A51 is required for mitochondrial NAD transport – Nora Kory, Jelmi uit de Bos, Sanne van der Rijt, Nevena Jankovic, Miriam Güra, Nicholas Arp, Izabella A. Pena, Gyan Prakash, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini. https://advances.sciencemag.org/content/early/2020/09/08/sciadv.abe5310

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis – Zhen Cai, Chien-Feng Li, Fei Han, Chunfang Liu, Anmei Zhang, Che-Chia Hsu, Danni Peng, Xian Zhang, Guoxiang Jin, Abdol-Hossein Rezaeian, Guihua Wang, Weina Zhang, Bo-Syong Pan, Chi-Yun Wang, Yu-Hui Wang, Shih-Ying Wu, Shun-Chin Yang, Fang-Chi Hsu, Ralph B. D’Agostino Jr., Christina M. Furdui, Gregory L. Kucera, John S. Parks, Floyd H. Chilton, Chih-Yang Huang, Fuu-Jen Tsai, Boris Pasche, Kounosuke Watabe, Hui-Kuan Lin. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30648-1

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells – Sandra Valle, Sonia Alcalá, Laura Martin-Hijano, Pablo Cabezas-Sáinz, Diego Navarro, Edurne Ramos Muñoz, Lourdes Yuste, Kanishka Tiwary, Karolin Walter, Laura Ruiz-Cañas, Marta Alonso-Nocelo, Juan A. Rubiolo, Emilio González-Arnay, Christopher Heeschen, Laura Garcia-Bermejo, Patrick C. Hermann, Laura Sánchez, Patricia Sancho, Miguel Ángel Fernández-Moreno and Bruno Sainz Jr. https://www.nature.com/articles/s41467-020-18954-z

Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis – Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom and Laura C. Greaves. https://www.nature.com/articles/s43018-020-00112-5

Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma – Yu Qian, Xiao Liang, Pengzhou Kong, Yikun Cheng, Heyang Cui, Ting Yan, Jinghao Wang, Ling Zhang, Yiqian Liu, Shiping Guo, Xiaolong Cheng and Yongping Cui. https://www.nature.com/articles/s41419-020-03044-1


Starvation and metabolic stress


Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation – Chan Lee, Lilian Lamech, Eleanor Johns, Michael Overholtzer. https://www.sciencedirect.com/science/article/abs/pii/S1534580720306663

Metabolic control of acclimation to nutrient deprivation dependent on polyphosphate synthesis – Sanz-Luque , S. Saroussi, W. Huang, N. Akkawi, A. R. Grossman. https://advances.sciencemag.org/content/6/40/eabb5351

Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism – Alexander I. May, Mark Prescott and Yoshinori Ohsumi. https://www.nature.com/articles/s41467-020-18805-x

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition – Takefumi Onodera, Isao Momose, Hayamitsu Adachi, Yohko Yamazaki, Ryuichi Sawa, Shun-ichi Ohba and Manabu Kawada. http://www.jbc.org/content/early/2020/09/25/jbc.RA120.013893.abstract


Nutrient sensing / AMPK


The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids – Geoffrey G. Hesketh, Fotini Papazotos, Judy Pawling, Dushyandi Rajendran, James D. R. Knight, Sebastien Martinez, Mikko Taipale, Daniel Schramek, James W. Dennis, Anne-Claude Gingras. https://science.sciencemag.org/content/370/6514/351

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation – Steffi Heidenreich, Pamela Weber, Heike Stephanowitz, Konstantin M. Petricek, Till Schütte, Moritz Oster, Antti M. Salo, Miriam Knauer, Isabel Goehring, Na Yang, Nicole Witte, Anne Schumann, Manuela Sommerfeld, Matthias Muenzner, Johanna Myllyharju, Eberhard Krause and Michael Schupp. http://www.jbc.org/content/early/2020/10/06/jbc.RA120.014402.abstract

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking – Maria Casas, Rut Fadó, José Luis Domínguez, Aina Roig, Moena Kaku, Shigeru Chohnan, Montse Solé, Mercedes Unzeta, Alfredo Jesús Miñano-Molina, José Rodríguez-Álvarez, Eamonn James Dickson, Núria Casals. https://rupress.org/jcb/article/219/10/e201912045/152088

AMP-independent activator of AMPK for treatment of mitochondrial disorders – Tereza Moore, Rolando E Yanes, Melissa A Calton, Douglas Vollrath, Gregory M Enns, Tina M Cowan. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240517


Hypoxia


Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer – Kate E.R. Hollinshead, Seth J. Parker, Vinay V. Eapen, Joel Encarnacion-Rosado, Albert Sohn, Tugba Oncu, Michael Cammer, Joseph D. Mancias, Alec C. Kimmelman. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31220-1

Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment – Irene Bertolini, Jagadish C. Ghosh, Andrew V. Kossenkov, Sudheer Mulugu, Shiv Ram Krishn, Valentina Vaira, Jun Qin, Edward F. Plow, Lucia R. Languino, Dario C. Altieri. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30588-8

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia – Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian H. Heidel, Tina M. Schnöder, Spasenija Savic Prince, Lukas Bubendorf, Paolo Pinton, Ralph A. Schmid, Johanna Baumgartner, Stefan Freigang, Sabina A. Berezowska, Alessandro Rimessi and Georgia Konstantinidou. https://www.nature.com/articles/s41556-020-00592-8


IDH


Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition – Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert and Mioara Larion. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00229-2

Poly(ADP-ribose) Glycohydrolase Inhibition Sequesters NAD+ to Potentiate the Metabolic Lethality of Alkylating Chemotherapy in IDH-Mutant Tumor Cells – Hiroaki Nagashima, Christine K. Lee, Kensuke Tateishi, Fumi Higuchi, Megha Subramanian, Seamus Rafferty, Lisa Melamed, Julie J. Miller, Hiroaki Wakimoto and Daniel P. Cahill. https://cancerdiscovery.aacrjournals.org/content/10/11/1672  


Cancer Immunometabolism


Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells – Valentí Gómez , Thomas R. Eykyn, Rami Mustapha, Fabián Flores-Borja, Victoria Male, Paul R. Barber, Antonia Patsialou, Ryan Green, Fani Panagaki, Chun W. Li, Gilbert O. Fruhwirth, Susana Ros, Kevin M. Brindle, Tony Ng. https://stke.sciencemag.org/content/13/652/eaax4585

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis – Peishan Li, Ming Lu, Jiayuan Shi, Zheng Gong, Li Hua, Qing Li, Bora Lim, Xiang H.-F. Zhang, Xiaowen Chen, Sheng Li, Leonard D. Shultz and Guangwen Ren. https://www.nature.com/articles/s41590-020-0783-5


Metabolic inhibitors


5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation – Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers and Kang-Yell Choi. https://www.nature.com/articles/s41467-020-19173-2

Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma – Qinchao Hu, Jianmin Peng, Laibo Jiang, Wuguo Li, Qiao Su, Jiayu Zhang, Huan Li, Ming Song, Bin Cheng, Juan Xia and Tong Wu. https://www.nature.com/articles/s41419-020-03126-0


Miscellaneous


Probing single-cell metabolism reveals prognostic value of highly metabolically active circulating stromal cells in prostate cancer – Francesca Rivello , Kinga Matula, Aigars Piruska, Minke Smits, Niven Mehra, Wilhelm T. S. Huck. https://advances.sciencemag.org/content/6/40/eaaz3849

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense – Marta Bosch Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocío Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M. Templin, James E. B. Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A. Del Pozo, Matthew J. Sweet, Patricia T. Bozza, Steven P. Gross, Robert G. Parton, Albert Pol. https://science.sciencemag.org/content/370/6514/eaay8085

Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins – J.J. Hulmi, F. Penna, N. Pöllänen, T.A. Nissinen, J. Hentilä, L. Euro, J.H. Lautaoja, R. Ballarò, R. Soliymani, M. Baumann, O. Ritvos, E. Pirinen, M. Lalowski. https://www.sciencedirect.com/science/article/pii/S2212877820301204

Macrophage-derived glutamine boosts satellite cells and muscle regeneration – Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien De Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquière, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi and Massimiliano Mazzone. https://www.nature.com/articles/s41586-020-2857-9

Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling – Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo, Marco Vanoni, Christian M. Metallo, Rosa Maria Moresco and Lilia Alberghina. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00227-4


Reviews


Immunometabolic Interplay in the Tumor Microenvironment – Irem Kaymak, Kelsey S. Williams, Jason R. Cantor, Russell G. Jones. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30478-5#.X5r5lrvYA_U

The Janus-like role of proline metabolism in cancer – Lynsey Burke, Inna Guterman, Raquel Palacios Gallego, Robert G. Britton, Daniel Burschowsky, Cristina Tufarelli and Alessandro Rufini. https://www.nature.com/articles/s41420-020-00341-8

Filament formation by metabolic enzymes—A new twist on regulation – Eric M. Lynch, Justin M. Kollman, Bradley A. Webb. https://www.sciencedirect.com/science/article/abs/pii/S0955067420300521

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology – J. Kierans  C. T. Taylor. https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280572

Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy – Stephen M. Hatfield and Michail V. Sitkovsky. https://www.jci.org/articles/view/137554

Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth – Birkeland ES, Koch LM, Dechant R. https://www.frontiersin.org/articles/10.3389/fonc.2020.01561/full

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors – Marjolein M G Kes, Jan Van den Bossche, Arjan W Griffioen, Elisabeth J M Huijbers. https://www.sciencedirect.com/science/article/pii/S0304419X20301463?via%3Dihub

Metabolic compartmentalization at the leading edge of metastatic cancer cells – Kara Wolfe, Ryo Kamata, Kester Coutinho, Takanari Inoue and Atsuo T. Sasaki. https://www.frontiersin.org/articles/10.3389/fonc.2020.554272/abstract

Targeting the HIF2–VEGF axis in renal cell carcinoma – Toni K. Choueiri and William G. Kaelin Jr. https://www.nature.com/articles/s41591-020-1093-z

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity – Emma U. Hammarlund, Emily Flashman, Sofie Mohlin, Francesco Licausi. https://science.sciencemag.org/content/370/6515/eaba3512

Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies – Ruiyuan Xu, Jinshou Yang, Bo Ren, Huanyu Wang, Gang Yang, Yuan Chen, Lei You, and Yupei Zhao. https://www.frontiersin.org/articles/10.3389/fonc.2020.572722/full

Multifaceted role of branched-chain amino acid metabolism in cancer – Hui Peng, Yingfei Wang and Weibo Luo. https://www.nature.com/articles/s41388-020-01480-z

Metabolic rivalry: circadian homeostasis and tumorigenesis – Kenichiro Kinouchi and Paolo Sassone-Corsi. https://www.nature.com/articles/s41568-020-0291-9

Targeting EMT in Cancer with Repurposed Metabolic Inhibitors – Vignesh Ramesh, Thomas Brabletz, Paolo Ceppi. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30189-8

Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer – Zhaodong Ji, Yan Shen, Xu Feng, Yue Kong, Yang Shao, Jiao Meng, Xiaofei Zhang, and Gong Yang. https://www.frontiersin.org/articles/10.3389/fonc.2020.593017/full

Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function – Ariel Igal, Débora I.Sinner. https://www.sciencedirect.com/science/article/abs/pii/S1388198120302328

Editorial: Metabolic Plasticity of Cancer – Sara Rodríguez-Enríquez, Tuuli Kaambre, and Rafael Moreno-Sánchez. https://www.frontiersin.org/articles/10.3389/fonc.2020.607511/full

Editorial: Metabolism Meets Function: Untangling the Cross-Talk Between Signaling and Metabolism – Alessandra Castegna, Daniel W. McVicar, Paolo E. Porporato, Annalisa Campanella, Erika M. Palmieri, and Alessio Menga. https://www.frontiersin.org/articles/10.3389/fonc.2020.607511/full

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer – Ellen C. de Heer, Mathilde Jalving, and Adrian L. Harris. https://www.jci.org/articles/view/137552

Quantitative Fluxomics of Circulating Metabolites – Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa, Xiaoxuan Li, Caroline Bartman, Zhaoyue Zhang, Cholsoon Jang, Lin Wang, Wenyun Lu, Jennifer Rojas, Joseph Baur, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30371-5

TCA cycle signalling and the evolution of eukaryotes – Dylan G Ryan, Christian Frezza, Luke AJ O’Neill. https://www.sciencedirect.com/science/article/abs/pii/S0958166920301440


Comments


Free Asparagine or Die: Cancer Cells Require Proteasomal Protein Breakdown to Survive Asparagine Depletion – Kristian Davidsen and Lucas B. Sullivan. https://cancerdiscovery.aacrjournals.org/content/10/11/1632

The smell of death and deCYStiny: polyamines play the hero – Joseph A. Combs and Gina M. DeNicola. https://www.nature.com/articles/s42255-020-0260-3

Hitting Gliomas When They Are Down: Exploiting IDH-Mutant Metabolic Vulnerabilities – Christopher J. Pirozzi and Hai Yan. https://cancerdiscovery.aacrjournals.org/content/10/11/1629

Metabolic ageing drives tumour progression – Ulrike Harjes. https://www.nature.com/articles/s41568-020-00301-5

Immortalizing switch to OXPHOS – Paulina Strzyz. https://www.nature.com/articles/s41580-020-00301-1

Serine Restriction Alters Sphingolipid Synthesis to Lower Tumor Growth. https://cancerdiscovery.aacrjournals.org/content/10/10/1440.2

Relapse-Driving AML Cells Exhibit Pyrimidine-Synthesis Dependency. https://cancerdiscovery.aacrjournals.org/content/10/10/1438.2

Fasting May Complement Endocrine Therapy. https://cancerdiscovery.aacrjournals.org/content/10/11/1617.2

Tumor Cells Deplete Methionine via SLC43A2, Causing T-cell Dysfunction. https://cancerdiscovery.aacrjournals.org/content/10/11/1623.2

Metabolic Adaptation to Lymphoma Suppresses NK-Cell Antitumor Function. https://cancerdiscovery.aacrjournals.org/content/10/11/1621.2


Paolo Sassone-Corsi (1956–2020) – Eric Verdin. https://science.sciencemag.org/content/370/6516/532

Paolo Sassone-Corsi (1956–2020) – Selma Masri, Colin R. Goding, Todd Leff. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30481-2

MetaboList – September 2020


Amino acid metabolism


Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition – Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley and Michael E. Pacold. https://cancerdiscovery.aacrjournals.org/content/10/9/1352

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance – Nick van Gastel, Jessica B. Spinelli, Azeem Sharda, Amir Schajnovitz, Ninib Baryawno, Catherine Rhee, Toshihiko Oki, Eliane Grace, Heather J. Soled, Jelena Milosevic, David B. Sykes, Peggy P. Hsu, Matthew G. Vander Heiden, Charles Vidoudez, Sunia A. Trauger, Marcia C. Haigis, David T. Scadden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30367-3

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism – Ruoyan Xu, William Jones, Ewa Wilcz‐Villega, Ana SH Costa, Vinothini Rajeeve, Robert B Bentham, Kevin Bryson, Ai Nagano, Busra Yaman, Sheila Olendo Barasa, Yewei Wang, Claude Chelala, Pedro Cutillas, Gyorgy Szabadkai, Christian Frezza, Katiuscia Bianchi. https://www.embopress.org/doi/full/10.15252/embr.201948260

Cancer proteome and metabolite changes linked to SHMT2 – Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237981Systemic muscle wasting and coordinated tumour response drive tumourigenesis – Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets and Susumu Hirabayashi. https://www.nature.com/articles/s41467-020-18502-9

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth – Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran and Chuanyue Wu. https://www.nature.com/articles/s41467-020-18753-6


Lipid metabolism


Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer – Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash and Timothy C. Thompson. https://www.nature.com/articles/s41467-020-17645-z

Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction – Manish Chamoli, Anita Goyala, Syed Shamsh Tabrez, Atif Ahmed Siddiqui, Anupama Singh, Adam Antebi, Gordon J. Lithgow, Jennifer L. Watts and Arnab Mukhopadhyay. https://www.nature.com/articles/s41467-020-18690-4


Nucleotides and NAD/PH


Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors – Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S. Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-wei Shen, Nir Peled, Igor Ulitsky, Angel Porgador, Eytan Ruppin and Ayelet Erez. https://www.nature.com/articles/s43018-020-0106-7

Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism – Muskan Bhatia, Jyotika Thakur, Shradha Suyal, Ruchika Oniel, Rahul Chakraborty, Shalini Pradhan, Monika Sharma, Shantanu Sengupta, Sunil Laxman, Shyam Kumar Masakapalli and Anand Kumar Bachhawat. http://www.jbc.org/content/early/2020/09/15/jbc.RA120.015129.abstract

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma – Anna E. Gibson, Choh Yeung, Sameer H. Issaq, Victor J. Collins, Michael Gouzoulis, Yiping Zhang, Jiuping Ji, Arnulfo Mendoza and Christine M. Heske. https://www.nature.com/articles/s41389-020-00264-0


Glucose metabolism


Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis – Jonathan M. Ghergurovich, Mark Esposito, Zihong Chen, Joshua Z. Wang, Vrushank Bhatt, Taijin Lan, Eileen White, Yibin Kang, Jessie Yanxiang Guo and Joshua D. Rabinowitz. https://cancerres.aacrjournals.org/content/80/18/3820

Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane – Yi Rao, Seth Gammon, Niki M. Zacharias, Tracy Liu, Travis Salzillo, Yuanxin Xi, Jing Wang, Pratip Bhattacharya, and David Piwnica-Worms. https://www.pnas.org/content/117/36/22378.abstract?etoc


Mitochondria


A Cellular Mechanism to Detect and Alleviate Reductive Stress – Andrew G. Manford, Fernando Rodríguez-Pérez, Karen Y. Shih, Zhuo Shi, Charles A. Berdan, Mangyu Choe, Denis V. Titov, Daniel K. Nomura, Michael Rape. https://www.cell.com/cell/fulltext/S0092-8674(20)31076-X

Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction – Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, Benjamin Olenchock, Eugene Rhee, Andrew M. Intlekofer, Othon Iliopoulos, Edward Chouchani and Jing-Ruey Joanna Yeh. https://cancerres.aacrjournals.org/content/80/17/3492 

Metabolic rewiring in drug resistant cells exhibit higher OXPHOS and fatty acids as preferred major source to cellular energetics – Sameer Salunkhe, Saket V. Mishra, Atanu Ghorai, Aarti Hole, Pratik Chandrani, Amit Dutt, Murali Chilakapati, Shilpee Dutt. https://www.sciencedirect.com/science/article/pii/S000527282030150X 

SLC25A51 is a mammalian mitochondrial NAD+ transporter – Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne and Joseph A. Baur. https://www.nature.com/articles/s41586-020-2741-7


Starvation


Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis – Bryan King, Jingwen Araki, Wilhelm Palm and Craig B. Thompson. http://genesdev.cshlp.org/content/34/19-20/1345.abstract?etoc

GADD34 is a modulator of autophagy during starvation – Gennaro Gambardella , Leopoldo Staiano, Maria Nicoletta Moretti, Rossella De Cegli, Luca Fagnocchi, Giuseppe Di Tullio, Sara Polletti, Clarissa Braccia, Andrea Armirotti, Alessio Zippo, Andrea Ballabio, Maria Antonietta De Matteis, Diego di Bernardo. https://advances.sciencemag.org/content/6/39/eabb0205

Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming – Caitlyn B. Brashears, Meltem Barlin, William R. Ehrhardt, Richa Rathore, Matthew Schultze, Shin-Chen Tzeng, Brian A. Van Tine and Jason M. Held. https://www.nature.com/articles/s41419-020-02899-8

Differential regulation of autophagy during metabolic stress in astrocytes and neurons – Aditi Kulkarni, Audrey Dong, Vineet Vinay Kulkarni, Jessica Chen, Olivia Laxton, Anip Anand and Sandra Maday. https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1703354

Amino acid starvation inhibits autophagy in lipid droplet-deficient cells through mitochondrial dysfunction – Pierre Voisin, Marianne Bernard, Thierry Bergès, Matthieu Régnacq. https://portlandpress.com/biochemj/article-abstract/477/18/3613/226330


mTOR / AMPK


Phosphorylated Acetyl-CoA Carboxylase Is Associated with Clinical Benefit with Regorafenib in Relapsed Glioblastoma: REGOMA Trial Biomarker Analysis – Stefano Indraccolo, Gian Luca De Salvo, Martina Verza, Mario Caccese, Giovanni Esposito, Ilaria Piga, Paola Del Bianco, Marco Pizzi, Marina Paola Gardiman, Marica Eoli, Roberta Rudà, Alba Ariela Brandes, Toni Ibrahim, Simona Rizzato, Ivan Lolli, Vittorina Zagonel and Giuseppe Lombardi. https://clincancerres.aacrjournals.org/content/26/17/4478

Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling – Eleanor C. Warren, Stephanie Dooves, Eleonora Lugarà, Joseph Damstra-Oddy, Judith Schaf, Vivi M. Heine, Mathew C. Walker, and Robin S. B. Williams. https://www.pnas.org/content/117/38/23617.abstract?etoc

Cell death induced by dorsomorphin in adult T‐cell leukemia/lymphoma is AMPK‐independent – Akiyoshi Aikawa, Tomohiro Kozako, Yuichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Takeo Ohsugi, Shin‐ichiro Honda. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15239

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway – Erica De Zan , Ruud van Stiphout, Bianca V. Gapp, Vincent A. Blomen, Thijn R. Brummelkamp, Sebastian M.B. Nijman. https://stke.sciencemag.org/content/13/649/eaba5665 


IDH


Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells – Yi Xu, Yang Zhang, Juan C. García-Cañaveras, Lili Guo, Mengyuan Kan, Sixiang Yu, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang. https://science.sciencemag.org/content/369/6502/397/

Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma – Risheng Yang, Yuanlin Zhao, Yu Gu, Ying Yang, Xing Gao, Yuan Yuan, Liming Xiao, Jin Zhang, Chao Sun, Han Yang, Junhui Qin, Jing Li, Feng Zhang, Lijun Zhang and Jing Ye. https://www.nature.com/articles/s41388-020-01439-0 


Cancer Immunometabolism


Cancer SLC43A2 alters T cell methionine metabolism and histone methylation – Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Zeribe C. Nwosu, Li Zhang, Arkadiusz Czerwonka, Anna Pawłowska, Houjun Xia, Jing Li, Peng Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Rebecca Liu, Karen McLean, Marcin Cieslik, Arul M. Chinnaiyan, Witold Zgodziński, Grzegorz Wallner, Iwona Wertel, Karolina Okła, Ilona Kryczek, Costas A. Lyssiotis and Weiping Zou. https://www.nature.com/articles/s41586-020-2682-1

Seven-Gene Signature Based on Glycolysis Is Closely Related to the Prognosis and Tumor Immune Infiltration of Patients With Gastric Cancer – Shanshan Yu, Chuan Hu, Luya Cai, Xuedan Du, Fan Lin, Qiongjie Yu, Lixiao Liu, Cheng Zhang, Xuan Liu, Wenfeng Li, and Yu Zhan. https://www.frontiersin.org/articles/10.3389/fonc.2020.01778 


Metformin


AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation – Jeanine L. Van Nostrand, Kristina Hellberg, En-Ching Luo, Eric L. Van Nostrand, Alina Dayn, Jingting Yu, Maxim N. Shokhirev, Yelena Dayn, Gene W. Yeo and Reuben J. Shaw. http://genesdev.cshlp.org/content/34/19-20/1330.abstract?eto

Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial – Shuhong Wang, Yusheng Lin, Xiao Xiong, Lu Wang, Yi Guo, Yuping Chen, Shaobin Chen, Geng Wang, Peng Lin, Hongcai Chen, Sai-Ching Jim Yeung, Edwin Bremer and Hao Zhang. https://clincancerres.aacrjournals.org/content/26/18/4921

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways – Huairui Yuan, Ying Han, Xuege Wang, Ni Li, Qiuli Liu, Yuye Yin, Hanling Wang, Lulu Pan, Li Li, Kun Song, Tong Qiu, Qiang Pan, Qilong Chen, Guoying Zhang, Yi Zang, Minjia Tan, Jian Zhang, Qintong Li, Xiaoming Wang, Jun Jiang, Jun Qin. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30272-5


Miscellaneous


Age-induced accumulation of methylmalonic acid promotes tumour progression – Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt and John Blenis. https://www.nature.com/articles/s41586-020-2630-0

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas – Chan Chung, Stefan R. Sweha, Drew Pratt, Benita Tamrazi, Pooja Panwalkar, Adam Banda, Jill Bayliss, Debra Hawes, Fusheng Yang, Ho-Joon Lee, Mengrou Shan, Marcin Cieslik, Tingting Qin, Christian K. Werner, Daniel R. Wahl, Costas A. Lyssiotis, Zhiguo Bian, J. Brad Shotwell, Viveka Nand Yadav, Carl Koschmann, Arul M. Chinnaiyan, Stefan Blüml, Alexander R. Judkins, Sriram Venneti. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30369-X

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts – Wen-Chih Lee, Xing Ji, Itzhak Nissim, Fanxin Long. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31097-4

Defining the ATPome reveals cross-optimization of metabolic pathways – Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. https://www.nature.com/articles/s41467-020-18084-6

Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways – Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia and Jinglin Xia. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00225-6

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia – Martin Benej, Eliska Svastova, Radivojka Banova, Juraj Kopacek, Adriana Gibadulinova, Nicholas C. Denko, Martin Kery, Simona Arena, Andrea Scaloni, Monica Vitale, Nicola Zambrano, Ioanna Papandreou, and Silvia Pastorekova. https://www.frontiersin.org/articles/10.3389/fonc.2020.01462/full


Reviews


Mitochondrial Metabolism as a Target for Cancer Therapy – Karthik Vasan, Marie Werner, Navdeep S. Chandel. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30320-X

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take – Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt. https://www.embopress.org/doi/abs/10.15252/embr.202050635

Amino Assets: How Amino Acids Support Immunity – Beth Kelly, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30311-9 

Oxygen‐sensing mechanisms in cells – James W. Wilson, Dilem Shakir, Michael Batie, Mark Frost, Sonia Rocha. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15374 

If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease – Ffion R. Hammond, Amy Lewis, Philip M. Elks. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15476

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms – Clotilde Laussel, Sébastien Léon. https://www.sciencedirect.com/science/article/pii/S0006295220304494

Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis – Tao Jiang, Guangji Zhang and Zhaohuan Lou. https://www.frontiersin.org/articles/10.3389/fonc.2020.01788/full 

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications – Qinyao Wei, Yun Qian, Jun Yu and Chi Chun Wong. https://www.nature.com/articles/s41388-020-01432-7

Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring – Mariafrancesca Scalise, Lara Console, Filomena Rovella, Michele Galluccio, Lorena Pochini and Cesare Indiveri. https://www.mdpi.com/2073-4409/9/9/2028

Glutamine reliance in cell metabolism – Hee Chan Yoo, Ya Chun Yu, Yulseung Sung and Jung Min Han. https://www.nature.com/articles/s12276-020-00504-8

Metabolic Reprogramming is a Hallmark of Metabolism Itself – Miguel Ángel Medina. https://onlinelibrary.wiley.com/doi/10.1002/bies.202000058


Comments / other


Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation – Sharanya Sivanand and Matthew G. Vander Heiden. http://genesdev.cshlp.org/content/34/19-20/1253.abstract?etoc 

Cancer cells stock up in lymph vessels to survive – Barbara M. Grüner, Sarah-Maria Fendt. https://www.nature.com/articles/d41586-020-02383-5

ASS1igning purine dependency to cancer – Elodie Villa & Issam Ben-Sahra. https://www.nature.com/articles/s43018-020-00117-0

AMPK as a direct sensor of long-chain fatty acyl–CoA esters – D. Grahame Hardie. https://www.nature.com/articles/s42255-020-0249-y

Microenvironmental Aspartate Preserves Leukemic Cells from Therapy-Induced Metabolic Collapse – Lucille Stuani, Jean-Emmanuel Sarry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30421-6

An Antibody Attack against Body Wasting in Cancer – Maria Rohm, Stephan Herzig. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30416-2

Mitochondrial Oxidation of Ubiquinol Is Required for Tumorigenesishttps://cancerdiscovery.aacrjournals.org/content/10/9/1250.1


Paolo Sassone-Corsi (1956–2020) – Selma Masri, Colin R. Goding, Todd Leff. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30608-0

A tribute to Beth Levine (1960–2020) – Ralph J. DeBerardinis. https://www.jci.org/articles/view/142454


ISCaM 7th Annual Meeting Webinar Series, with focus on Systemic Metabolism and Cancer.

  • Systemic Metabolism and Cancer 1: Cancer Therapy and Diet. 20 October, 2020, 4pm. Karen Vousden, Valter D Longo, Jason W Locasale, Almut Schulze, 
  • Systemic Metabolism and Cancer 2: The Tumour Microenvironment. 27 October, 2020, 4pm. Jean-Ehrland Ricci, Katiuscia Bianchi, Kathrin Renner 

Direct access: https://drive.google.com/file/d/1On-B0W74p6BgZpEDX1JqQChm_dVbcifo/view?usp=sharing

EMBO Workshop: Cancer Immunometabolism

Organizers: Cristina Muñoz-Pinedo, Jean-Ehrland Ricci, Eric Eldering

Sitges (Barcelona), Spain, March 15-17 2021

https://meetings.embo.org/event/21-cancer

MetaboList – August 2020


Amino acids


Serine restriction alters sphingolipid diversity to constrain tumour growth – Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani Gengatharan, Antonio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace, Alan Saghatelian and Christian M. Metallo. https://www.nature.com/articles/s41586-020-2609-x

Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis – Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31006-8

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway – Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan and Jeffrey A. Moscow. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00214-9

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model – Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N. Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, François Vallette, Woo-Ping Ge, François Paris, Ralph J. DeBerardinis and Claire Pecqueur. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00215-8

Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours – Ziwen Zhu, Abhinav Achreja, Noah Meurs, Olamide Animasahun, Sarah Owen, Anjali Mittal, Pooja Parikh, Ting-Wen Lo, Janusz Franco-Barraza, Jiaqi Shi, Valerie Gunchick, Mara H. Sherman, Edna Cukierman, Andrew M. Pickering, Anirban Maitra, Vaibhav Sahai, Meredith A. Morgan, Sunitha Nagrath, Theodore S. Lawrence and Deepak Nagrath. https://www.nature.com/articles/s42255-020-0226-5


Glucose metabolism


HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors – Kangjing Xu, Zhongyuan He, Ming Chen, Nuofan Wang, Diancai Zhang, Li Yang, Zekuan Xu and Hao Xu. https://www.nature.com/articles/s41419-020-02768-4

p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis – Fang Wang, Xiao-Mei Qi, Ryan Wertz, Matthew Mortensen, Catherine Hagen, John Evans, Yuri Sheinin, Michael James, Pengyuan Liu, Susan Tsai, James Thomas, Alexander Mackinnon, Michael Dwinell, Charles R. Myers, Ramon Bartrons Bach, Liwu Fu and Guan Chen. https://cancerres.aacrjournals.org/content/80/16/3251

Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer – Elisabeth Smolle, Petra Leko, Elvira Stacher‐Priehse, Luka Brcic, Amin El‐Heliebi, Lilli Hofmann, Franz Quehenberger, Andelko Hrzenjak, Helmut H. Popper, Horst Olschewski, Katharina Leithner. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12780


Lipid metabolism


Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress – Xiang Cheng, Feng Geng, Meixia Pan, Xiaoning Wu, Yaogang Zhong, Chunyan Wang, Zhihua Tian, Chunming Cheng, Rui Zhang, Vinay Puduvalli, Craig Horbinski, Xiaokui Mo, Xianlin Han, Arnab Chakravarti, Deliang Guo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30303-X

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites – Claudie Bosc, Nicolas Broin, Marjorie Fanjul, Estelle Saland, Thomas Farge, Charly Courdy, Aurélie Batut, Rawand Masoud, Clément Larrue, Sarah Skuli, Nicolas Espagnolle, Jean-Christophe Pagès, Alice Carrier, Frédéric Bost, Justine Bertrand-Michel, Jérôme Tamburini, Christian Récher, Sarah Bertoli, Véronique Mansat-De Mas, Stéphane Manenti, Jean-Emmanuel Sarry and Carine Joffre. https://www.nature.com/articles/s41467-020-17882-2

Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression – Ji Hye Yang, Nam Hee Kim, Jun Seop Yun, Eunae Sandra Cho, Yong Hoon Cha, Sue Bean Cho, Seon-Hyeong Lee, So Young Cha, Soo-Youl Kim, Jiwon Choi, Tin-Tin Manh Nguyen, Sunghyouk Park, Hyun Sil Kim and Jong In Yook. https://www.life-science-alliance.org/content/3/7/e202000683.abstract

Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells – James Drury, Piotr G. Rychahou, Daheng He, Naser Jafari, Yekaterina Y. Zaytseva, Chi Wang, Eun Y. Lee, Heidi L. Weiss, and Bernard Mark Evers. https://www.frontiersin.org/articles/10.3389/fonc.2020.01185/full


Nucleotides


Purine metabolism regulates DNA repair and therapy resistance in glioblastoma – Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis and Daniel R. Wahl. https://www.nature.com/articles/s41467-020-17512-x

New regulatory mechanism‐based inhibitors of aspartate transcarbamoylase for potential anticancer drug development – Zhen Lei, Biying Wang, Zhifang Lu, Nan Wang, Hongwei Tan, Jimin Zheng, Zongchao Jia. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15220

Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage – Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31062-7


Mitochondria


Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria – Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter. https://elifesciences.org/articles/58041

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression – Yotaro Kudo, Masayuki Sugimoto, Esperanza Arias, Hiroaki Kasashima, Thekla Cordes, Juan F. Linares, Angeles Duran, Yuki Nakanishi, Naoko Nakanishi, Antoine L’Hermitte, Alex Campos, Nadia Senni, Tarmo Rooslid, Lewis R. Roberts, Ana Maria Cuervo, Christian M. Metallo, Michael Karin, Maria T. Diaz-Meco, Jorge Moscat. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30268-3

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex – Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza and James A. Nathan. https://www.nature.com/articles/s41467-020-17862-6

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite – Minervo Perez, Daniel W. Bak, Sarah E. Bergholtz, Daniel R Crooks, Bhargav Srinivas Arimilli, Youfeng Yang, Eranthie Weerapana, W. Marston Linehan and Jordan L. Meier. http://www.jbc.org/content/early/2020/08/19/jbc.AC120.014993.abstract

Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition – Alba Roca-Portoles, Giovanny Rodriguez-Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian M. Mackay, Katelyn O’Neill, Leandro Lemgruber, Xu Luo & Stephen W. G. Tait. https://www.nature.com/articles/s41419-020-02867-2


Starvation


p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth – Ada Nowosad, Pauline Jeannot, Caroline Callot, Justine Creff, Renaud Thierry Perchey, Carine Joffre, Patrice Codogno, Stephane Manenti and Arnaud Besson. https://www.nature.com/articles/s41556-020-0554-4

Glutamine deprivation alters the origin and function of cancer cell exosomes – Shih‐Jung Fan, Benjamin Kroeger, Pauline P Marie, Esther M Bridges, John D Mason, Kristie McCormick, Christos E Zois, Helen Sheldon, Nasullah Khalid Alham, Errin Johnson, Matthew Ellis, Maria Irina Stefana, Cláudia C Mendes, Stephen Mark Wainwright, Christopher Cunningham, Freddie C Hamdy, John F Morris, Adrian L Harris, Clive Wilson, Deborah CI Goberdhan. https://www.embopress.org/doi/full/10.15252/embj.2019103009


Hypoxia


Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment – Irene Bertolini. Jagadish C. Ghosh. Andrew V. Kossenkov. Sudheer Mulugu. Shiv Ram Krishn. Valentina Vaira. Jun Qin. Edward F. Plow. Lucia R. Languino. Dario C. Altieri. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30588-8

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice – Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries and Ian J. Frew. https://www.nature.com/articles/s41467-020-17873-3


Miscellaneous


Lymph protects metastasizing melanoma cells from ferroptosis – Jessalyn M. Ubellacker, Alpaslan Tasdogan, Vijayashree Ramesh, Bo Shen, Evann C. Mitchell, Misty S. Martin-Sandoval, Zhimin Gu, Michael L. McCormick, Alison B. Durham, Douglas R. Spitz, Zhiyu Zhao, Thomas P. Mathews and Sean J. Morrison. https://www.nature.com/articles/s41586-020-2623-z

Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin – Ramy Ayoub, Rebecca M. Ruddy, Elizabeth Cox, Adeoye Oyefiade, Daniel Derkach, Suzanne Laughlin, Benjamin Ades-aron, Zahra Shirzadi, Els Fieremans, Bradley J. MacIntosh, Cynthia B. de Medeiros, Jovanka Skocic, Eric Bouffet, Freda D. Miller, Cindi M. Morshead and Donald J. Mabbott. https://www.nature.com/articles/s41591-020-0985-2

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice – Rowena Suriben, Michael Chen, Jared Higbee, Julie Oeffinger, Richard Ventura, Betty Li, Kalyani Mondal, Zhengyu Gao, Dina Ayupova, Pranali Taskar, Diana Li, Shelley R. Starck, Hung-I Harry Chen, Michele McEntee, Subhash D. Katewa, Van Phung, Marilyn Wang, Avantika Kekatpure, Damodharan Lakshminarasimhan, Andre White, Andrea Olland, Raj Haldankar, Mark J. Solloway, Jer-Yuan Hsu, Yan Wang, Jie Tang, Darrin A. Lindhout and Bernard B. Allan. https://www.nature.com/articles/s41591-020-0945-x

In situ Metabolic Profiling of Ovarian Cancer Tumor Xenografts: A Digital Pathology Approach – Ilaria Piga, Martina Verza, Francesca Montenegro, Giorgia Nardo, Elisabetta Zulato, Tiziana Zanin, Paola Del Bianco, Giovanni Esposito and Stefano Indraccolo. https://www.frontiersin.org/articles/10.3389/fonc.2020.01277/full


Reviews


Lactate modulation of immune responses in inflammatory versus tumour microenvironments – Michelangelo Certo, Chin-Hsien Tsai, Valentina Pucino, Ping-Chih Ho and Claudio Mauro. https://www.nature.com/articles/s41577-020-0406-2

Glycolysis – a key player in the inflammatory response – Gonzalo Soto‐Heredero, Manuel M. Gómez de las Heras, Enrique Gabandé‐Rodríguez, Jorge Oller, María Mittelbrunn. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15327

Tracking the carbons supplying gluconeogenesis – Ankit M. Shah and Fredric E. Wondisford. http://www.jbc.org/content/early/2020/08/13/jbc.REV120.012758.abstract

Metabolism and the Epigenome: A Dynamic Relationship – Spencer A. Haws, Cassandra M. Leech, John M. Denu. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30092-X

Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks – Rachel J. Perry and Gerald I. Shulman. http://www.jbc.org/content/early/2020/08/12/jbc.REV120.008387.abstract

Metabolism of immune cells in cancer – Robert D. Leone and Jonathan D. Powell. https://www.nature.com/articles/s41568-020-0273-y

Endogenous toxic metabolites and implications in cancer therapy – Namgyu Lee, Meghan E. Spears, Anne E. Carlisle and Dohoon Kim. https://www.nature.com/articles/s41388-020-01395-9

Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth – Eivind Salmorin Birkeland, Lisa Maria Koch and Reinhard Dechant. https://www.frontiersin.org/articles/10.3389/fonc.2020.01561/full

Manipulation of Mitochondrial Plasticity Changes the Metabolic Competition Between “Foe” and “Friend” During Tumor Malignant Transformation – Hui Tian, Baofu Zhang, Liantao Li, Gang Wang, Huizhong Li and JunNian Zheng. https://www.frontiersin.org/articles/10.3389/fonc.2020.01692/full

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy – Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Daqing Zhao, Boyang Jason Wu and Xiangyan Li. https://www.frontiersin.org/articles/10.3389/fonc.2020.01510/full

The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation – Cyrielle L. Bouchez, Noureddine Hammad, Sylvain Cuvellier, Stéphane Ransac, Michel Rigoulet and Anne Devin. https://www.frontiersin.org/articles/10.3389/fonc.2020.01333/full

Oncology Therapeutics Targeting the Metabolism of Amino Acids – Muhammad N, Lee HM, Kim J. https://www.mdpi.com/2073-4409/9/8/1904

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions – Lavanya Ponnusamy, Sathan Raj Natarajan, Karthik Thangaraj, Ravi Manoharan. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20300986

Cholesterol metabolism: New functions and therapeutic approaches in cancer – Huanji Xu, Sheng Zhou, Qiulin Tang, Hongwei Xia, Feng Bi. https://www.sciencedirect.com/science/article/abs/pii/S0304419X2030113X

Inside the hypoxic tumour: reprogramming of the DDR and radioresistance – Katheryn Begg and Mahvash Tavassoli. https://www.nature.com/articles/s41420-020-00311-0


Comments


Give and take: competition for BCAAs in the tumour microenvironment – Russell E. Ericksen and Weiping Han. https://www.nature.com/articles/s42255-020-0239-0

PKCλ/ι Loss Induces Metabolic Reprogramming in Liver Cancer: Hitting Two Birds with One Stone? – Pierluigi Ramadori, Xin Li, Mathias Heikenwalder. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30364-0

Fasting-mimicking diet plus chemotherapy in breast cancer treatment – Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini and Filippo de Braud. https://www.nature.com/articles/s41467-020-18194-1

The IDH1 Inhibitor Ivosidenib May Slow IDH1-Mutant Glioma Progression – https://cancerdiscovery.aacrjournals.org/content/10/8/OF6

MetaboList – July 2020


Glucose sensing and metabolism


Dihydroxyacetone phosphate signals glucose availability to mTORC1 – Jose M. Orozco, Patrycja A. Krawczyk, Sonia M. Scaria, Andrew L. Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini. https://www.nature.com/articles/s42255-020-0250-5

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancerMaría Gutiérrez-Salmerón, José Manuel García-Martínez, Javier Martínez-Useros, María Jesús Fernández-Aceñero, Benoit Viollet, Severine Olivier, Jagat Chauhan, Silvia R. Lucena, Antonio De la Vieja, Colin R. Goding, Ana Chocarro-Calvo, Custodia García-Jiménez. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000732

Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways – Min Li, Xuxiao He, Weixing Guo, Hongming Yu, Shicheng Zhang, Ningning Wang, Guijun Liu, Rina Sa, Xia Shen, Yabo Jiang, Yufu Tang, Yujuan Zhuo, Chunzhao Yin, Qiaochu Tu, Nan Li, Xiaoqun Nie, Yu Li, Zhimin Hu, Hanwen Zhu, Jianping Ding, Zi Li, Te Liu, Fan Zhang, He Zhou, Shengxian Li, Jiang Yue, Zheng Yan, Shuqun Cheng, Yongzhen Tao and Huiyong Yin. https://www.nature.com/articles/s43018-020-0086-7

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells – M. Caillot, J. Bourgeais, H. Dakik, É. Costé, N. M. Mazure, É. Lelièvre, O. Coqueret, O. Hérault, F. Mazurier and B. Sola. https://www.nature.com/articles/s41389-020-00253-3


Amino acid metabolism


Extracellular serine controls epidermal stem cell fate and tumour initiation – Sanjeethan C. Baksh, Pavlina K. Todorova, Shiri Gur-Cohen, Brian Hurwitz, Yejing Ge, Jesse S. S. Novak, Matthew T. Tierney, June dela Cruz-Racelis, Elaine Fuchs and Lydia W. S. Finley. https://www.nature.com/articles/s41556-020-0525-9

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells – Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell. https://www.jci.org/articles/view/131859

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression – Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu and Qing-Bai She. https://www.nature.com/articles/s41467-020-17067-x

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth – Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman and Mei Kong. https://www.nature.com/articles/s41467-020-17181-w


Lipid sensing and metabolism


Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms – Stephen L. Pinkosky, John W. Scott, Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Rebecca J. Ford, Christopher G. Langendorf, Naomi X. Y. Ling, Tracy L. Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William. Smiles, Kevin R. W. Ngoei, Michael W. Parker, Yan Yan, Karsten Melcher, Bruce E. Kemp, Jonathan S. Oakhill and Gregory R. Steinberg. https://www.nature.com/articles/s42255-020-0245-2

De Novo Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma – Nima Abbassi-Ghadi, Stefan S. Antonowicz, James S. McKenzie, Sacheen Kumar, Juzheng Huang, Emrys A. Jones, Nicole Strittmatter, Gemma Petts, Hiromi Kudo, Stephen Court, Jonathan M. Hoare, Kirill Veselkov, Robert Goldin, Zoltán Takáts and George B. Hanna. https://cancerres.aacrjournals.org/content/80/13/2764


Mitochondria and hypoxia


Mitochondrial ubiquinol oxidation is necessary for tumour growth – Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S. McElroy, Marie Werner, Hermon Kihshen, Colleen R. Reczek, Samuel E. Weinberg, Peng Gao, Elizabeth M. Steinert, Raul Piseaux, G. R. Scott Budinger and Navdeep S. Chandel. https://www.nature.com/articles/s41586-020-2475-6

Na+ controls hypoxic signalling by the mitochondrial respiratory chainPablo Hernansanz-Agustín, Carmen Choya-Foces, Susana Carregal-Romero, Elena Ramos, Tamara Oliva, Tamara Villa-Piña, Laura Moreno, Alicia Izquierdo-Álvarez, J. Daniel Cabrera-García, Ana Cortés, Ana Victoria Lechuga-Vieco, Pooja Jadiya, Elisa Navarro, Esther Parada, Alejandra Palomino-Antolín, Daniel Tello, Rebeca Acín-Pérez, Juan Carlos Rodríguez-Aguilera, Plácido Navas, Ángel Cogolludo, Iván López-Montero, Álvaro Martínez-del-Pozo, Javier Egea, Manuela G. López, John W. Elrod, Jesús Ruíz-Cabello, Anna Bogdanova, José Antonio Enríquez and Antonio Martínez-Ruiz. https://www.nature.com/articles/s41586-020-2551-y

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells – Jie Li , Ekta Agarwal, Irene Bertolini, Jae Ho Seo, M. Cecilia Caino, Jagadish C. Ghosh, Andrew V. Kossenkov, Qin Liu, Hsin-Yao Tang, Aaron R. Goldman, Lucia R. Languino, David W. Speicher, Dario C. Altieri. https://stke.sciencemag.org/content/13/642/eaaz8240

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival – Cesar Cardenas , Alenka Lovy, Eduardo Silva-Pavez, Felix Urra, Craig Mizzoni, Ulises Ahumada-Castro, Galdo Bustos, Fabian Jaňa, Pablo Cruz, Paula Farias, Elizabeth Mendoza, Hernan Huerta, Paola Murgas, Martin Hunter, Melany Rios, Oscar Cerda, Irene Georgakoudi, Armen Zakarian, Jordi Molgó, J. Kevin Foskett. https://stke.sciencemag.org/content/13/640/eaay1212

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells by modulating metabolism and death pathways – J. Vial, P. Huchedé, S. Fagault, F. Basset, M. Rossi, J. Geoffray, H. Soldati, J. Bisaccia, M. H. Elsensohn, M. Creveaux, D. Neves, J. Y. Blay, F. Fauvelle, F. Bouquet, N. Streichenberger, N. Corradini, C. Bergeron, D. Maucort-Boulch, P. Castets, M. Carré, K. Weber and M. Castets. https://www.nature.com/articles/s41420-020-00302-1

Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth – L. M. Schiffmann, J. P. Werthenbach, F. Heintges-Kleinhofer, J. M. Seeger, M. Fritsch, S. D. Günther, S. Willenborg, S. Brodesser, C. Lucas, C. Jüngst, M. C. Albert, F. Schorn, A. Witt, C. T. Moraes, C. J. Bruns, M. Pasparakis, M. Krönke, S. A. Eming, O. Coutelle and H. Kashkar. https://www.nature.com/articles/s41467-020-17472-2

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells – Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00219-4


Starvation/metabolic stress


Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damageJoffrey Pelletier, Ferran Riaño‐Canalias, Eugènia Almacellas, Caroline Mauvezin, Sara Samino, Sonia Feu, Sandra Menoyo, Ana Domostegui, Marta Garcia‐Cajide, Ramon Salazar, Constanza Cortés, Ricard Marcos, Albert Tauler, Oscar Yanes, Neus Agell, Sara C Kozma, Antonio Gentilella, George Thomas. https://www.embopress.org/doi/full/10.15252/embj.2019103838

Systematic quantitative analysis of ribosome inventory during nutrient stress – Heeseon An, Alban Ordureau, Maria Körner, Joao A. Paulo and J. Wade Harper. https://www.nature.com/articles/s41586-020-2446-y

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress – Ahmad Kobiita, Svenja Godbersen, Elisa Araldi, Umesh Ghoshdastider, Marc W. Schmid, Giatgen Spinas, Holger Moch, Markus Stoffel. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30827-5


AMPK/mTOR


VRK-1 extends life span by activation of AMPK via phosphorylation – Sangsoon Park , Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, Seung-Jae V. Lee. https://advances.sciencemag.org/content/6/27/eaaw7824

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndromeGennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E. G. de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagnì, Pier Paolo Di Fiore, Lukas A. Huber and Andrea Ballabio. https://www.nature.com/articles/s41586-020-2444-0


Metabolic reprogramming (general)


Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma – Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden  . https://elifesciences.org/articles/56782

The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolismM. Carmen Lafita-Navarro, Lizbeth Perez-Castro, Lauren G. Zacharias, Spencer Barnes, Ralph J. DeBerardinis and Maralice Conacci-Sorrell. http://www.jbc.org/content/early/2020/07/01/jbc.AC120.014189.abstract 

Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells – Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova and Mónica Marín. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00216-7


Cancer Immunometabolism


An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells – Shogo Kumagai, Yosuke Togashi, Chika Sakai, Akihito Kawazoe, Masahito Kawazu, Toshihide Ueno, Eiichi Sato, Takeshi Kuwata, Takahiro Kinoshita, Masami Yamamoto, Sachiyo Nomura, Tetsuya Tsukamoto, Hiroyuki Mano, Kohei Shitara, Hiroyoshi Nishikawa. https://www.cell.com/immunity/fulltext/S1074-7613(20)30271-5

Tumors induce de novo steroid biosynthesis in T cells to evade immunity – Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields and Sarah A. Teichmann. https://www.nature.com/articles/s41467-020-17339-6

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells – Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell. https://www.jci.org/articles/view/131859


Methods


Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers – Andre Koit, Natalja Timohhina, Laura Truu, Vladimir Chekulayev, Shivakumar Gudlawar, Igor Shevchuk, Katrin Lepik, Lea Mallo, Riina Kutner, Vahur Valvere and Tuuli Kaambre. https://www.frontiersin.org/articles/10.3389/fonc.2020.01053/full

Metabolite AutoPlotter – an application to process and visualise metabolite data in the web browser – Matthias Pietzke and Alexei Vazquez. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00220-x


Miscellaneous


Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility – James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30861-5

Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscleCristina Sánchez‐González, Cristina Nuevo‐Tapioles, Juan Cruz Herrero Martín, Marta P Pereira, Sandra Serrano Sanz, Ana Ramírez de Molina, José M Cuezva, Laura Formentini. https://www.embopress.org/doi/full/10.15252/embj.2019103812

Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma – Anil R. Singh, Juan J. Gu, Qunling Zhang, Pallawi Torka, Suchitra Sundaram, Cory Mavis and Francisco J. Hernandez-Ilizaliturri. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00213-w


Reviews


Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments – Fuming Li, M. Celeste Simon. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30497-4

Lactate: the ugly duckling of energy metabolism – Joshua D. Rabinowitz and Sven Enerbäck. https://www.nature.com/articles/s42255-020-0243-4

Metabolite sensing and signaling in Cancer – Yi-Ping Wang, Jin-Tao Li, Jia Qu, Miao Yin and Qun-Ying Lei. http://www.jbc.org/content/early/2020/07/07/jbc.REV119.007624.abstract

Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer ImmunotherapyElisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo, Tomás Alarcón,Ruth Lupu, Joaquim Bosch-Barrera and Javier A. Menendez. https://www.mdpi.com/2072-6694/12/7/1757

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy? – Hannah J. Smith, Arpit Sharma, William B. Mair. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30461-5

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational ModificationsOscar A. Tarazona, Olivier Pourquié. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30543-8

Integration of Hippo-YAP Signaling with MetabolismConsuelo Ibar, Kenneth D. Irvine. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30504-9

The Lysosome at the Intersection of Cellular Growth and Destruction – Hijai R. Shin, Roberto Zoncu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30460-3

Fructose contributes to the Warburg effect for cancer growth – Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan and Richard J. Johnson. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00222-9

Mitochondrial Stress Response and Cancer – Jordan O’Malley, Rahul Kumar, Joseph Inigo, Nagendra Yadava, Dhyan Chandra. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30139-4

Metabolic Modulation of Immunity: A New Concept in Cancer ImmunotherapyLuana Guerra, Lynn Bonetti, Dirk Brenner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30829-9


Comments


A spoonful of DHAP keeps mTORC1 running on sugars – Gerta Hoxhaj, Jason W. Locasale and Issam Ben-Sahra. https://www.nature.com/articles/s42255-020-0246-1

AMPK as a direct sensor of long-chain fatty acyl–CoA estersD. Grahame Hardie. https://www.nature.com/articles/s42255-020-0249-y

A ‘fast’er way to treat breast cancer – Marcus D. Goncalves and Lewis C. Cantley. https://www.nature.com/articles/s42255-020-0225-6

Starve a cold, and perhaps a cancer – Daniel Haensel and Anthony E. Oro. https://www.nature.com/articles/s41556-020-0543-7

Integrating serine with tumour initiation – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-0287-5

MetaboList – June 2020


Serine / glycine / one carbon


Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcomaMadi Y. Cissé , Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, Hélène Delpech, Romain Riscal, Giuseppe Arena, Frédéric Chibon, Sophie Le Gellec, Aurélie Maran-Gonzalez, Marie-Christine Chateau, Charles Theillet, Sébastien Carrere, Jean-Charles Portais, Laurent Le Cam, Laetitia K. Linares. https://stm.sciencemag.org/content/12/547/eaay2163.full

SHMT Inhibition Is Effective and Synergizes With Methotrexate in T-cell Acute Lymphoblastic LeukemiaJuan C García-Cañaveras, Olga Lancho, Gregory S Ducker, Jonathan M Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D Rabinowitz. https://pubmed.ncbi.nlm.nih.gov/32382081

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencingSara Parsa, Ana Ortega-Molina, Hsia-Yuan Ying, Man Jiang, Matt Teater, Jiahui Wang, Chunying Zhao, Ed Reznik, Joyce P. Pasion, David Kuo, Prathibha Mohan, Shenqiu Wang, Jeannie M. Camarillo, Paul M. Thomas, Neeraj Jain, Javier Garcia-Bermudez, Byoung-kyu Cho, Wayne Tam, Neil L. Kelleher, Nicholas Socci, Ahmet Dogan, Elisa De Stanchina, Giovanni Ciriello, Michael R. Green, Sheng Li, Kivanc Birsoy, Ari M. Melnick and Hans-Guido Wendel. https://www.nature.com/articles/s43018-020-0080-0

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progressionJuan Liu, Cen Zhang, Hao Wu, Xiao-Xin Sun, Yanchen Li, Shan Huang, Xuetian Yue, Shou-En Lu, Zhiyuan Shen, Xiaoyang Su, Eileen White, Bruce G. Haffty, Wenwei Hu, and Zhaohui Feng. https://www.jci.org/articles/view/132876


Other amino acids


Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic CancerSeth J. Parker, Caroline R. Amendola, Kate E.R. Hollinshead, Qijia Yu, Keisuke Yamamoto, Joel Encarnación-Rosado, Rebecca E. Rose, Madeleine M. LaRue, Albert S.W. Sohn, Doug E. Biancur, Joao A. Paulo, Steven P. Gygi, Drew R. Jones, Huamin Wang, Mark R. Philips, Dafna Bar-Sagi, Joseph D. Mancias and Alec C. Kimmelman. https://cancerdiscovery.aacrjournals.org/content/10/7/1018

Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cellsAimin Cai, Hailun Zheng, Zhiwei Chen, Xinlu Lin, Chen Li, Qing yao, Yangzom D. Bhutia, Vadivel Ganapathy, Ruijie Chen, Longfa Kou. https://portlandpress.com/biochemj/article/477/10/1923/223853

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrenceChao-Chieh Lin, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, Jeremy Force, Jeffrey R. Marks, Tso-Pang Yao, James V. Alvarez and Jen-Tsan Chi. https://www.nature.com/articles/s41418-020-0499-y


Glucose metabolism


Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast CancerLisa M. Becker, Joyce T. O’Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu, Raghu Kalluri. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30671-9

PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancerDanna Yeerken, Ruoxi Hong, Yan Wang, Ying Gong, Rui Liu, Di Yang, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang, Qimin Zhan. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233750

Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor MicroenvironmentPei-pei Hou, Li-juan Luo, Hang-zi Chen, Qi-tao Chen, Xue-li Bian, Sheng-fu Wu, Jia-xin Zhou, Wen-xiu Zhao, Jian-ming Liu, Xiao-min Wang, Zhi-yuan Zhang, Lu-ming Yao, Qinghua Chen, Dawang Zhou, Qiao Wu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30305-1

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblastsAkiko Kogure, Yutaka Naito, Yusuke Yamamoto, Masakazu Yashiro, Tohru Kiyono, Kazuyoshi Yanagihara, Kosei Hirakawa, Takahiro Ochiya. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234613

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen and Ning Zhang. https://www.nature.com/articles/s41467-020-16966-3

Label-free sensing of exosomal MCT1 and CD147  for tracking metabolic reprogramming and  malignant progression in gliomaA. Thakur , G. Qiu, C. Xu, X. Han, T. Yang, S. P. NG, K. W. Y. Chan, C. M. L. Wu, Y. Lee. https://advances.sciencemag.org/content/6/26/eaaz6119


Lipid metabolism


REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumorsShuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke,  Krushna Chandra Patra, Elma Zaganjor, Kenneth Ross, Yusuke Mizukami,  Sarah Jeanfavre, Athena Chen, Mari Mino-Kenudson, Sridhar Ramaswamy,  Clary Clish, Marcia Haigis, Nabeel Bardeesy and Leif W. Ellisen. http://genesdev.cshlp.org/content/34/11-12/751.abstract?etoc

PHGDH supports liver ceramide synthesis and sustains lipid homeostasisYun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth and Gina M. DeNicola. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00212-x

Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolismErol C. Bayraktar, Konnor La, Kara Karpman, Gokhan Unlu, Ceren Ozerdem, Dylan J. Ritter, Hanan Alwaseem, Henrik Molina, Hans-Heinrich Hoffmann, Alec Millner, G. Ekin Atilla-Gokcumen, Eric R. Gamazon, Amy R. Rushing, Ela W. Knapik, Sumanta Basu and Kıvanç Birsoy. https://www.nature.com/articles/s42255-020-0206-9

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolismMichael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone and Jason Moffat. https://www.nature.com/articles/s42255-020-0211-z

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancerKaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson and Martin C. Sadowski. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00217-6

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived EicosanoidsNikos Koundouros, Evdoxia Karali, Aurelien Tripp, Adamo Valle, Paolo Inglese, Nicholas J.S. Perry, David J. Magee, Sara Anjomani Virmouni, George A. Elder, Adam L. Tyson, Maria Luisa Dória, Antoinette van Weverwijk, Renata F. Soares, Clare M. Isacke, Jeremy K. Nicholson, Robert C. Glen, Zoltan Takats, George Poulogiannis. https://www.cell.com/cell/fulltext/S0092-8674(20)30686-3


Nucleotides


ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine SynthesisEunus S. Ali, Umakant Sahu, Elodie Villa, Brendan P. O’Hara, Peng Gao, Cynthia Beaudet, Antony W. Wood, John M. Asara, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30302-6

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxiaKarolina Losenkova, Mariachiara Zuccarini, Marika Karikoski, Juha Laurila, Detlev Boison, Sirpa Jalkanen and Gennady G. Yegutkin. http://jcs.biologists.org/content/133/10/jcs241463?etoc


Mitochondria


Defective NADPH production in mitochondrial disease complex I causes inflammation and cell deathEduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench and Pere Puigserver. https://www.nature.com/articles/s41467-020-16423-1

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growthŽiva Frangež, Yuniel Fernández-Marrero, Darko Stojkov, S. Morteza Seyed Jafari, Robert E. Hunger, Valentin Djonov, Carsten Riether and Hans-Uwe Simon. https://www.nature.com/articles/s41388-020-1339-8

Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal TumorHuang WK, Gao J, Chen Z, Shi H, Yuan J, Cui HL, Yeh CN, Bränström R, Larsson C, Li S, Lui WO. https://www.mdpi.com/2073-4409/9/6/1333

ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK InhibitionWeinan Guo, Jinyuan Ma, Yuqi Yang, Sen Guo, Weigang Zhang, Tao Zhao, Xiuli Yi, Huina Wang, Shiyu Wang, Yu Liu, Wei Dai, Xuguang Chen, Qiong Shi, Gang Wang, Tianwen Gao and Chunying Li. https://clincancerres.aacrjournals.org/content/26/11/2725


Nutrient sensing / starvation


H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell DeathYilei Zhang, Jiejun Shi, Xiaoguang Liu, Zhenna Xiao, Guang Lei, Hyemin Lee, Pranavi Koppula, Weijie Cheng, Chao Mao, Li Zhuang, Li Ma, Wei Li and Boyi Gan. https://cancerres.aacrjournals.org/content/80/11/2243

Leucine regulates autophagy via acetylation of the mTORC1 component raptorSung Min Son, So Jung Park, Eleanna Stamatakou, Mariella Vicinanza, Fiona M. Menzies and David C. Rubinsztein. https://www.nature.com/articles/s41467-020-16886-2

Metabolic energy sensing by mammalian CLC anion/proton exchangersMatthias Grieschat, Raul E Guzman, Katharina Langschwager, Christoph Fahlke, Alexi K Alekov. https://www.embopress.org/doi/full/10.15252/embr.201947872?campaign=woletoc

The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERKQin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15144?campaign=woletoc

Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylationCarlo Yague-Sanz, Yann Vanrobaeys, Ronan Fernandez, Maxime Duval, Marc Larochelle, Jude Beaudoin, Julien Berro, Simon Labbé, Pierre-Étienne Jacques and François Bachand. http://genesdev.cshlp.org/content/34/13-14/883.abstract?etoc


mTOR / AMPK


Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitorsChase H. Melick, Jenna L. Jewell. https://portlandpress.com/biochemj/article/477/10/1847/222875

Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic MutationsPatrick Hansmann, Anne Brückner, Stephan Kiontke, Bianca Berkenfeld, Guiscard Seebohm, Pascal Brouillard, Miikka Vikkula, Floor E. Jansen, Mark Nellist, Andrea Oeckinghaus, Daniel Kümmel. https://www.cell.com/structure/fulltext/S0969-2126(20)30177-5

FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restrictionAvantika Gupta, Hugo Stocker. https://elifesciences.org/articles/53159

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancerArcadi Cipponi, David L. Goode, Justin Bedo, Mark J. McCabe, Marina Pajic, David R. Croucher, Alvaro Gonzalez Rajal, Simon R. Junankar, Darren N. Saunders, Pavel Lobachevsky, Anthony T. Papenfuss, Danielle Nessem, Max Nobis, Sean C. Warren, Paul Timpson, Mark Cowley, Ana C. Vargas, Min R. Qiu, Daniele G. Generali, Shivakumar Keerthikumar, Uyen Nguyen, Niall M. Corcoran, Georgina V. Long, Jean-Yves Blay, David M. Thomas. https://science.sciencemag.org/content/368/6495/1127

AMP-activated protein kinase regulates alternative pre-mRNA splicing by phosphorylation of SRSF1Eri Matsumoto, Kaho Akiyama, Takuya Saito, Yu Matsumoto, Ken-Ichi Kobayashi, Jun Inoue, Yuji Yamamoto, Tsukasa Suzuki. https://portlandpress.com/biochemj/article/477/12/2237/225005


Diet and cancer


Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trialStefanie de Groot, Rieneke T. Lugtenberg, Danielle Cohen, Marij J. P. Welters, Ilina Ehsan, Maaike P. G. Vreeswijk, Vincent T. H. B. M. Smit, Hiltje de Graaf, Joan B. Heijns, Johanneke E. A. Portielje, Agnes J. van de Wouw, Alex L. T. Imholz, Lonneke W. Kessels, Suzan Vrijaldenhoven, Arnold Baars, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Valter D. Longo, Hanno Pijl, Judith R. Kroep & Dutch Breast Cancer Research Group (BOOG). https://www.nature.com/articles/s41467-020-16138-3

Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor MacrophagesLianliang Liu, Rong Jin, Jiaqing Hao, Jun Zeng, Di Yin, Yanmei Yi, Mingming Zhu, Anita Mandal, Yuan Hua, Chin K. Ng, Nejat K. Egilmez, Edward R. Sauter and Bing Li. https://cancerres.aacrjournals.org/content/80/12/2564

A Randomized Controlled Trial of a 6-Month Low-Carbohydrate Intervention on Disease Progression in Men with Recurrent Prostate Cancer: Carbohydrate and Prostate Study 2 (CAPS2)Stephen J. Freedland, Jenifer Allen, Aubrey Jarman, Taofik Oyekunle, Andrew J. Armstrong, Judd W. Moul, Howard M. Sandler, Edwin Posadas, Dana Levin, Emily Wiggins, Lauren E. Howard, Yuan Wu and Pao-Hwa Lin. https://clincancerres.aacrjournals.org/content/26/12/3035


Biguanides / Antifolates


GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-PhosphateJianjiang Xie, Jianheng Ye, Zhiduan Cai, Yong Luo, Xuejin Zhu, Yulin Deng, Yuanfa Feng, Yingke Liang, Ren Liu, Zhaodong Han, Yuxiang Liang, Yu Zheng, Rujun Mo, Yangjia Zhuo, Yongding Wu, Funeng Jiang, Jianguo Zhu, Chin-Lee Wu and Weide Zhong. https://cancerres.aacrjournals.org/content/80/11/2150 

Repression of LKB1 by miR-1792 Sensitizes MYC-Dependent Lymphoma to Biguanide TreatmentIzreig S, Gariepy A, Kaymak I, Bridges HR, Donayo AO, Bridon G, DeCamp LM, Kitchen-Goosen SM, Avizonis D, Sheldon RD, Laister RC, Minden MD, Johnson NA, Duchaine TF, Rudoltz MS, Yoo S, Pollak MN, Williams KS, Jones RG. https://pubmed.ncbi.nlm.nih.gov/32478334/

Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma–Derived CellsYasuo Takashima, Azusa Hayano and Ryuya Yamanaka. https://clincancerres.aacrjournals.org/content/26/11/2754


Methods


Using arterial–venous analysis to characterize cancer metabolic consumption in patientsNanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G. Zacharias, Hong Lin, Hieu S. Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J. DeBerardinis, Hao Xu and Woo-ping Ge. https://www.nature.com/articles/s41467-020-16810-8

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal AdenocarcinomaKazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Shun Kishimoto, Nobu Oshima, Rajani Choudhuri, Stephen S. Adler, Elaine M. Jagoda, Keita Saito, Nallathamby Devasahayam, Peter L. Choyke, James B. Mitchell and Murali C. Krishna. https://cancerres.aacrjournals.org/content/80/11/2087

Comparative assessment of purified saponins as permeabilization agents during respirometryCorinna Dawid, Daniela Weber, Eva Musiol, Vanessa Janas, Sebastian Baur, Roman Lang, Tobias Fromme. https://www.sciencedirect.com/science/article/abs/pii/S0005272820301018


Cancer Immunometabolism


Inosine is an alternative carbon source for CD8+-T-cell function under glucose restrictionTingting Wang, J. N. Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Hayley Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Penghui Lin, Zayda Lizbeth Piedra-Quintero, Mireia Guerau-de-Arellano, Kevin A. Cassady, Song Guo Zheng, Jun Yang, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan and Ruoning Wang. https://www.nature.com/articles/s42255-020-0219-4


Miscellaneous


T cells with dysfunctional mitochondria induce multimorbidity and premature senescenceGabriela Desdín-Micó, Gonzalo Soto-Heredero, Juan Francisco Aranda, Jorge Oller, Elisa Carrasco, Enrique Gabandé-Rodríguez, Eva Maria Blanco, Arantzazu Alfranca, Lorena Cussó, Manuel Desco, Borja Ibañez, Arancha R. Gortazar, Pablo Fernández-Marcos, Maria N. Navarro, Bruno Hernaez, Antonio Alcamí, Francesc Baixauli, María Mittelbrunn. https://science.sciencemag.org/content/368/6497/1371

Intracellular pH controls WNT downstream of glycolysis in amniote embryosMasayuki Oginuma, Yukiko Harima, Oscar A. Tarazona, Margarete Diaz-Cuadros, Arthur Michaut, Tohru Ishitani, Fengzhu Xiong and Olivier Pourquié. https://www.nature.com/articles/s41586-020-2428-0

Oncometabolites suppress DNA repair by disrupting local chromatin signallingParker L. Sulkowski, Sebastian Oeck, Jonathan Dow, Nicholas G. Economos, Lily Mirfakhraie, Yanfeng Liu, Katelyn Noronha, Xun Bao, Jing Li, Brian M. Shuch, Megan C. King, Ranjit S. Bindra and Peter M. Glazer. https://www.nature.com/articles/s41586-020-2363-0

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1Rodrigo Romero, Francisco J. Sánchez-Rivera, Peter M. K. Westcott, Kim L. Mercer, Arjun Bhutkar, Alexander Muir, Tania J. González Robles, Swanny Lamboy Rodríguez, Laura Z. Liao, Sheng Rong Ng, Leanne Li, Caterina I. Colón, Santiago Naranjo, Mary Clare Beytagh, Caroline A. Lewis, Peggy P. Hsu, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks. https://www.nature.com/articles/s43018-020-0071-1

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolismHo JJD, Balukoff NC, Theodoridis PR, Wang M, Krieger JR, Schatz JH, Lee S. https://pubmed.ncbi.nlm.nih.gov/32472050/


Reviews


The Molecular Link from Diet to Cancer Cell MetabolismShree Bose, Annamarie E. Allen, Jason W. Locasale. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30319-1

Dietary Approaches to Cancer TherapyMylène Tajan, Karen H. Vousden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30204-X

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer ImmunotherapyJackie E. Bader, Kelsey Voss, Jeffrey C. Rathmell. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30355-5

Drilling for Oil: Tumor-Surrounding Adipocytes Fueling CancerCamille Attané, Catherine Muller. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30084-4

Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolismBouthelier A, Aragonés J. https://www.sciencedirect.com/science/article/abs/pii/S0167488920300914

Systemic effects of mitochondrial stressRaz BarZiv, Theodore Bolas, Andrew Dillin. https://www.embopress.org/doi/abs/10.15252/embr.202050094?campaign=woletoc

You are what you eat – How nutrition and metabolism shape the genome through epigeneticsTill Bartke, Robert Schneider. https://www.sciencedirect.com/science/article/pii/S2212877820300612

Compartmentalised acyl-CoA metabolism and roles in chromatin regulationSophie Trefely, Claudia D. Lovell, Nathaniel W. Snyder, Kathryn E. Wellen. https://www.sciencedirect.com/science/article/pii/S2212877820300077

The taming of PARP1 and its impact on NAD+ metabolismSarah Hurtado-Bagès, Gunnar Knobloch, Andreas G. Ladurner, Marcus Buschbeck. https://www.sciencedirect.com/science/article/pii/S2212877820300223

Metabolic Escape Routes of Cancer Stem Cells and Therapeutic OpportunitiesTurdo A, Porcelli G, D’Accardo C, Franco SD, Verona F, Forte S, Giuffrida D, Memeo L, Todaro M, Stassi G. https://www.mdpi.com/2072-6694/12/6/1436

Role of amino acids in regulation of ROS balance in cancerJaune-Pons E, Vasseur S. https://www.sciencedirect.com/science/article/abs/pii/S0003986120304471?via%3Dihub

Chromatin-remodeling links metabolic signaling to gene expressionAshby J.Morrison. https://www.sciencedirect.com/science/article/pii/S2212877820300466

Metabolic Regulation of Tissue Stem CellsSuzanne N. Shapira, Heather R. Christofk. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30075-1

Cytokine-like Roles for Metabolites in ImmunityZbigniew Zasłona, Luke A.J. O’Neill. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30228-8 


Comments


Extracellular serine feeds cancer skin stem cellsKim Baumann. https://www.nature.com/articles/s41580-020-0261-9

Tumour metabolites hinder DNA repairLei-Lei Chen, Yue Xiong. https://www.nature.com/articles/d41586-020-01569-1

Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancerW. Brian Dalton. https://www.jci.org/articles/view/137411

Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer – https://cancerdiscovery.aacrjournals.org/content/10/6/757.1

MetaboList – May 2020


Glucose metabolism


A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway – Jonathan M. Ghergurovich, Juan C. García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, Mari Carmen Gomez-Cabrera, Agustín Lahoz, Jing Fan, Ulf H. Beier, Hahn Kim and Joshua D. Rabinowitz. https://www.nature.com/articles/s41589-020-0533-x

N6-methyladenosine regulates glycolysis of cancer cells through PDK4 – Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin and Hongsheng Wang. https://www.nature.com/articles/s41467-020-16306-5

Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts – Kozlov AM, Lone A, Betts DH, Cumming RC. https://www.nature.com/articles/s41598-020-65193-9

Glycolytic biomarkers predict transformation in patients with follicular lymphoma – Ida Monrad, Charlotte Madsen, Kristina Lystlund Lauridsen, Bent Honoré, Trine Lindhardt Plesner, Stephen Hamilton-Dutoit, Francesco d’Amore, Maja Ludvigsen. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233449


Methionine, Serine, one-carbon


Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function – Henry Kurniawan, Davide G. Franchina, Luana Guerra, Lynn Bonetti, Leticia Soriano – Baguet, Melanie Grusdat, Lisa Schlicker, Oliver Hunewald, Catherine Dostert, Myriam P. Merz, Carole Binsfeld, Gordon S. Duncan, Sophie Farinelle, Yannic Nonnenmacher, Jillian Haight, Dennis Das Gupta, Anouk Ewen, Rabia Taskesen, Rashi Halder, Ying Chen, Christian Jäger, Markus Ollert, Paul Wilmes, Vasilis Vasiliou, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Jonathan D. Turner, Tak W. Mak, Michael Lohoff, Johannes Meiser, Karsten Hiller, Dirk Brenner. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30119-4

DISTINCT PATTERN OF ONE-CARBON METABOLISM, A NUTRIENT-SENSITIVE PATHWAY, IN INVASIVE BREAST CANCER: A METABOLOMIC STUDYJéssica Reis Santos, Dan Linetzky Waitzberg, Ismael Dale Cotrim Guerreiro da Silva, Tharcisio Citrangulo Tortelli Junior, Luciana Rodrigues Carvalho Barros, Gisele André Baptista Canuto, Andréa Tedesco Faccio, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Marina Franco Maggi Tavares, Ana Cristina Martinez, Ângela Flavia Logullo, Raquel Suzana M.M. Torrinhas, and Graziela Ravacci. https://www.oncotarget.com/article/27575/text/

Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity – Nairita Maitra, Chong He, Heidi M Blank, Mitsuhiro Tsuchiya, Birgit Schilling,  Matt Kaeberlein, Rodolfo Aramayo, Brian K Kennedy , Michael Polymenis. https://elifesciences.org/articles/53127 


Other amino acids / polyamines


Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress – Simon Schwörer, Mirela Berisa, Sara Violante, Weige Qin, Jiajun Zhu, Ronald C Hendrickson, Justin R Cross, Craig B Thompson. https://www.embopress.org/doi/abs/10.15252/embj.2019103334

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma – Tjaden B, Baum K, Marquardt V, Simon M, Trajkovic-Arsic M, Kouril T, Siebers B, Lisec J, Siveke JT, Schulte JH, Benary U, Remke M, Wolf J, Schramm A. https://www.nature.com/articles/s41598-020-64040-1

Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs – Akihiko Sakamoto, Yusuke Terui, Takeshi Uemura, Kazuei Igarashi and Keiko Kashiwagi. http://www.jbc.org/content/early/2020/05/06/jbc.RA120.013833.abstract

Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling – Shailer B. Martin, William S. Reiche, Nicholas A. Fifelski, Alexander J. Schultz, Spencer J. Stanford, Alexander A. Martin, Danielle L. Nack, Bernhard Radlwimmer, Michael P. Boyer, Elitsa A. Ananieva. https://portlandpress.com/biochemj/article/477/9/1579/222659/Leucine-and-branchedchain-amino-acid-metabolism

Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum – Cassandra E. Holbert, Matthew Dunworth, Jackson R. Foley, Tiffany T. Dunston, Tracy Murray Stewart and Robert A. Casero Jr. http://www.jbc.org/content/early/2020/05/19/jbc.RA120.013867.abstract


Nucleotides


Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex – Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A. https://www.jbc.org/content/early/2020/05/21/jbc.RA119.012175

SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network – Archan Chakraborty, Wei-Cheng Lin, Yu-Tsun Lin, Kuang-Jing Huang, Pei-Yu Wang, Ian Yi-Feng Chang, Hsiang-Iu Wang, Kung-Ting Ma, Chun-Yen Wang, Xuan-Rong Huang, Yen-Hsien Lee, Bi-Chang Chen, Ya-Ju Hsieh, Kun-Yi Chien, Tzu-Yang Lin, Ji-Long Liu, Li-Ying Sung, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai. https://jcs.biologists.org/content/133/9/jcs240200?etoc

Methotrexate Elicits Pro-Respiratory and Anti-Growth Effects by Promoting AMPK Signaling – David J Papadopoli, Eric H Ma, Dominic Roy, Mariana Russo, Gaëlle Bridon, Daina Avizonis, Russell G Jones, Julie St-Pierre. https://www.nature.com/articles/s41598-020-64460-z


Mitochondria


Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitorsÁlvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals. https://www.embopress.org/doi/full/10.15252/emmm.201911217

Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer – Jason R Brown, Daniel K. Chan, Jessica J Shank, Kent A. Griffith, Huihui Fan, Robert Szulawski, Kun Yang, R. Kevin Reynolds, Carolyn Johnston, Karen McLean, Shitanshu Uppal, J. Rebecca Liu, Lourdes Cabrera, Sarah E Taylor, Brian C. Orr, Francesmary Modugno, Pooja Mehta, Michael Bregenzer, Geeta Mehta, Hui Shen, Lan Coffman, and Ronald J. Buckanovich. https://insight.jci.org/articles/view/133247

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I – Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst,  Barrie Kellam, Anne E Willis. https://elifesciences.org/articles/55845

Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells – Kenta Kuramoto, Masahiro Yamamoto, Shuhei Suzuki, Tomomi Sanomachi, Keita Togashi, Shizuka Seino, Chifumi Kitanaka, Masashi Okada. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15187


Starvation / metabolic stress


Distinct Mitochondrial Defects Trigger the Integrated Stress Response Depending on the Metabolic State of the Cell – Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha. https://elifesciences.org/articles/49178

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy – David Pla‐Martín, Désirée Schatton, Janica L Wiederstein, Marie‐Charlotte Marx, Salim Khiati, Marcus Krüger, Elena I Rugarli. https://www.embopress.org/doi/full/10.15252/embj.2019102731

AKT Ser/Thr kinase increases V-ATPase–dependent lysosomal acidification in response to amino acid starvation in mammalian cells – Michael P. Collins, Laura A. Stransky and Michael Forgac. http://www.jbc.org/content/early/2020/05/14/jbc.RA120.013223.abstract


Nutrient sensing / ATF4


p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators – Charles N. Birts , Arindam Banerjee, Matthew Darley, Charles R. Dunlop, Sarah Nelson, Sharandip K. Nijjar, Rachel Parker, Jonathan West, Ali Tavassoli, Matthew J. J. Rose-Zerilli, Jeremy P. Blaydes. https://stke.sciencemag.org/content/13/630/eaau9529

Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1 – Jianyin Long, Daniel L. Galvan, Koki Mise, Yashpal S. Kanwar, Li Li, Naravat Poungvarin, Paul A. Overbeek, Benny H Chang and Farhad R. Danesh. http://www.jbc.org/content/early/2020/05/28/jbc.RA120.013228.abstract

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion – Aharon Helman, Andrew L. Cangelosi, Jeffrey C. Davis, Quan Pham, Arielle Rothman, Aubrey L. Faust, Juerg R. Straubhaar, David M. Sabatini, Douglas A. Melton. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30186-8

ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila – Sebastian Sorge, Jonas Theelke, Kerem Yildirim, Helen Hertenstein, Ellen McMullen, Stephan Müller, Christian Altbürger, Stefanie Schirmeier, Ingrid Lohmann. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30612-4


IDH


Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism – Di Yu, Yang Liu, Yiqiang Zhou, Victor Ruiz-Rodado, Mioara Larion, Guowang Xu, and Chunzhang Yang. https://www.pnas.org/content/117/18/9964.abstract?etoc


Miscellaneous


Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis [CAD is the deamidase] – Jun Zhao, Mao Tian, Shu Zhang, Alireza Delfarah, Ruoyun Gao, Youliang Rao, Ali Can Savas, Anjie Lu, Larissa Bubb, Xiao Lei, Rosa Moshirian, Wenjie Zhu, Cheng Peng, Taijiao Jiang, Lin Chen, Nicholas A. Graham, Pinghui Feng. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30188-1

Common biochemical properties of metabolic genes recurrently dysregulated in tumors – Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis and Sriram Chandrasekaran. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0211-1

N‐acetyl‐l‐tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals – Takashi Matsumura, Outa Uryu, Fumikazu Matsuhisa, Keiji Tajiri, Hitoshi Matsumoto, Yoichi Hayakawa. https://www.embopress.org/doi/abs/10.15252/embr.201949211

Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation – Accalia Fu, Juan Carlos Alvarez-Perez, Daina Avizonis, Tatsuya Kin, Scott B. Ficarro, Dong Wook Choi, Esra Karakose, Mehmet G. Badur, Lindsay Evans, Carolina Rosselot, Gaelle Bridon, Gregory H. Bird, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jurre J. Kamphorst, Andrew F. Stewart, A. M. James Shapiro, Jarrod A. Marto, Loren D. Walensky, Russell G. Jones, Adolfo Garcia-Ocana and Nika N. Danial. https://www.nature.com/articles/s42255-020-0199-4


Reviews


Advances into understanding metabolites as signaling molecules in cancer progression – Joyce Y. Liu, Kathryn E. Wellen. https://www.sciencedirect.com/science/article/abs/pii/S095506742030020X

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic CellsFernando Erra Díaz, Valeria Ochoa, Antonela Merlotti, Ezequiel Dantas, Ignacio Mazzitelli, Virginia Gonzalez Polo, Juan Sabatté, Sebastián Amigorena, Elodie Segura, Jorge Geffner. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30562-3

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions – Jawed A. Siddiqui, Ramesh Pothuraju, Maneesh Jain, Surinder K.Batra, Mohd W.Nasser. https://www.sciencedirect.com/science/article/abs/pii/S0304419X20300159

Cholesterol and beyond – The role of the mevalonate pathway in cancer biology – Andy Göbel, Martina Rauner, Lorenz C. Hofbauer, Tilman D. Rachner. https://www.sciencedirect.com/science/article/abs/pii/S0304419X1930174X

Death by lipids: the role of small nucleolar RNAs in metabolic stress – Jean E. Schaffer. http://www.jbc.org/content/early/2020/05/11/jbc.AW120.011105.abstract

The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance – Margot Riggi, Beata Kusmider and Robbie Loewith. http://jcs.biologists.org/content/133/9/jcs242040?etoc

Metabolic Flux Analysis: Moving beyond Static MetabolomicsSilvia Radenkovic, Ivan Vuckovic, Ian R. Lanza. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30059-1

Folding the Mitochondrial UPR into the Integrated Stress ResponseNadine S. Anderson, Cole M. Haynes. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30055-6

The Complex Interplay between Antioxidants and ROS in Cancer – Isaac S. Harris, Gina M. DeNicola. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30058-1

Emerging Mechanisms and Disease Relevance of Ferroptosis – Brent R. Stockwell, Xuejun Jiang, Wei Gu. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30054-4

Reprogramming of serine, glycine and one-carbon metabolism in cancer – Li AM, Ye J. https://pubmed.ncbi.nlm.nih.gov/32439610/

Chromatin as a key consumer in the metabolite economy – Diehl KL, Muir TW. https://www.nature.com/articles/s41589-020-0517-x

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death – Daher B, Vučetić M, Pouysségur J. https://www.frontiersin.org/articles/10.3389/fonc.2020.00723/full


Comments


Glutamine: A bad guy for antitumor immunity? – Lewis Z. Shi. https://stm.sciencemag.org/content/12/542/eabb7093

Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers – G. Aaron Hobbs, Channing J. Der. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30055-4

A BAD portion of glucose can be good for inflamed beta cells – Christian Frezza. https://www.nature.com/articles/s42255-020-0198-5

CLUHing in mitochondria to starvation – Annalisa M. VanHook. https://stke.sciencemag.org/content/13/631/eabc6690

MetaboList – April 2020


Amino acid metabolism


Cysteine depletion induces pancreatic tumor ferroptosis in mice – Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, Vinee Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Steve A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, Wei Gu, E. Scott Seeley, Everett Stone, George Georgiou, Uri Manor, Alina Iuga, Geoffrey M. Wahl, Brent R. Stockwell, Costas A. Lyssiotis, Kenneth P. Olive. https://science.sciencemag.org/content/368/6486/85

Identifying strategies to target the metabolic flexibility of tumours – Andrés Méndez-Lucas, Wei Lin, Paul C. Driscoll, Nathalie Legrave, Laura Novellasdemunt, Chencheng Xie, Mark Charles, Zena Wilson, Neil P. Jones, Stephen Rayport, Manuel Rodríguez-Justo, Vivian Li, James I. MacRae, Nissim Hay, Xin Chen and Mariia Yuneva. https://www.nature.com/articles/s42255-020-0195-8

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma – Kewen Hu, Kun Li, Jing Lv, Jie Feng, Jing Chen, Haigang Wu, Feixiong Cheng, Wenhao Jiang, Jieqiong Wang, Haixiang Pei, Paul J. Chiao, Zhenyu Cai, Yihua Chen, Mingyao Liu, and Xiufeng Pang. https://www.jci.org/articles/view/124049

Serine Catabolism Feeds NADH when Respiration Is Impaired – Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30114-5

ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase – Robert T. Williams, Rohiverth Guarecuco, Leah A. Gates, Douglas Barrows, Maria C. Passarelli, Bryce Carey, Lou Baudrier, Swarna Jeewajee, Konnor La, Benjamin Prizer, Sohail Malik, Javier Garcia-Bermudez, Xiphias Ge Zhu, Jason Cantor, Henrik Molina, Thomas Carroll, Robert G. Roeder, Omar Abdel-Wahab, C. David Allis, Kıvanç Birsoy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30123-6

EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma – Rui Yang, Xiuxiu Li, Yanan Wu, Guanghui Zhang, Xiaoran Liu, Yanping Li, Yonghua Bao, Wancai Yang and Hongjuan Cui. https://www.nature.com/articles/s41388-020-1199-2

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival – Longfei Deng, Pengbo Yao, Le Li, Fansen Ji, Shuang Zhao, Chang Xu, Xun Lan and Peng Jiang. https://www.nature.com/articles/s41467-020-15573-6

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers – Suman Mukhopadhyay, Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin, Serguei V. Kozlov, Dwight V. Nissley and Frank McCormick. https://cancerres.aacrjournals.org/content/80/8/1630

Interaction of the neutral amino acid transporter ASCT2 with basic amino acids – Elias Ndaru, Rachel-Ann A. Garibsingh, Laura Zielewicz, Avner Schlessinger, Christof Grewer. https://portlandpress.com/biochemj/article/477/8/1443/222575/Interaction-of-the-neutral-amino-acid-transporter


Glucose metabolism


KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer – Hunain Alam, Ming Tang, Mayinuer Maitituoheti, Shilpa S. Dhar, Manish Kumar, Chae Young Han, Chandrashekar R. Ambati, Samir B. Amin, Bingnan Gu, Tsai-Yu Chen, Yu-Hsi Lin, Jichao Chen, Florian L. Muller, Nagireddy Putluri, Elsa R. Flores, Francesco J. DeMayo, Laura Baseler, Kunal Rai, Min Gyu Lee. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30106-9

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3) – D. A. Richardson, P. Sritangos, A. D. James, A. Sultan and J. I. E. Bruce. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0210-2

Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis – Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang and Chunlin Shao. https://link-springer-com.sire.ub.edu/article/10.1007/s11010-020-03729-3

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition – Aaminah Khan, Emanuele Valli, Hayley Lam, David A. Scott, Jayne Murray, Kimberley M. Hanssen, Georgina Eden, Laura D. Gamble, Rupinder Pandher, Claudia L. Flemming, Sophie Allan, Andrei L. Osterman, Michelle Haber, Murray D. Norris, Jamie I. Fletcher and Denise M. T. Yu. https://www.nature.com/articles/s41388-020-1235-2

Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth – Simranjot Bawa, David S Brooks, Kathryn E Neville, Marla Tipping, Md Abdul Sagar, Joseph A Kollhoff, Geetanjali Chawla, Brian V Geisbrecht, Jason M Tennessen, Kevin W Eliceiri, Erika R Geisbrecht. https://elifesciences.org/articles/52358


Lipid metabolism


The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis – Daqian Xu, Zheng Wang, Yan Xia, Fei Shao, Weiya Xia, Yongkun Wei, Xinjian Li, Xu Qian, Jong-Ho Lee, Linyong Du, Yanhua Zheng, Guishuai Lv, Jia-shiun Leu, Hongyang Wang, Dongming Xing, Tingbo Liang, Mien-Chie Hung and Zhimin Lu. https://www.nature.com/articles/s41586-020-2183-2

Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian CancerDaniela Criscuolo, Rosario Avolio, Giovanni Calice, Chiara Laezza, Simona Paladino, Giovanna Navarra, Francesca Maddalena, Fabiana Crispo, Cristina Pagano, Maurizio Bifulco, Matteo Landriscina, Danilo Swann Matassa, Franca Esposito. https://www.mdpi.com/2073-4409/9/4/828

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling – Divya Venkatesh, Nicholas A. O’Brien, Fereshteh Zandkarimi, David R. Tong, Michael E. Stokes, Denise E. Dunn, Everett S. Kengmana, Allegra T. Aron, Alyssa M. Klein, Joleen M. Csuka, Sung-Hwan Moon, Marcus Conrad, Christopher J. Chang, Donald C. Lo, Angelo D’Alessandro, Carol Prives and Brent R. Stockwell. http://genesdev.cshlp.org/content/34/7-8/526.abstract?etoc

Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance – Abir Mukherjee, Chun-Yi Chiang, Helen A. Daifotis, Kristin M. Nieman, Johannes F. Fahrmann, Ricardo R. Lastra, Iris L. Romero, Oliver Fiehn and Ernst Lengyel. https://cancerres.aacrjournals.org/content/80/8/1748


Nucleotides


IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex – Alexander J. Valvezan, Molly C. McNamara, Spencer K. Miller, Margaret E. Torrence, John M. Asara, Elizabeth P. Henske, and Brendan D. Manning. https://insight.jci.org/articles/view/135071

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells – Vidhi Pareek, Hua Tian, Nicholas Winograd, Stephen J. Benkovic. https://science.sciencemag.org/content/368/6488/283


Mitochondria


IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism – Atsuhito Tsuji, Takumi Akao, Takahiro Masuya, Masatoshi Murai and Hideto Miyoshi. http://www.jbc.org/content/early/2020/04/14/jbc.RA120.013366.abstract

High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung – Mitchell Frederick, Heath D. Skinner, Sawad A. Kazi, Andrew G. Sikora and Vlad C. Sandulache. https://www.nature.com/articles/s41598-020-63448-z


Starvation


Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells – Franziska Püschel, Francesca Favaro, Jaime Redondo-Pedraza, Estefanía Lucendo, Raffaella Iurlaro, Sandrine Marchetti, Blanca Majem, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Eric Chevet, and Cristina Muñoz-Pinedo. https://www.pnas.org/content/early/2020/04/17/1913707117/

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer – Xiaoguang Liu, Kellen Olszewski, Yilei Zhang, Esther W. Lim, Jiejun Shi, Xiaoshan Zhang, Jie Zhang, Hyemin Lee, Pranavi Koppula, Guang Lei, Li Zhuang, M. James You, Bingliang Fang, Wei Li, Christian M. Metallo, Masha V. Poyurovsky and Boyi Gan. https://www.nature.com/articles/s41556-020-0496-x

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11) – Itsuki Yamaguchi, Shige H. Yoshimura and Hironori Katoh. http://www.jbc.org/content/early/2020/04/07/jbc.RA119.012213.abstract

Reorganization of budding yeast cytoplasm upon energy depletion – Guendalina Marinia, Elisabeth Nüskea, Weihua Lenga, Simon Albertia, and Gaia Pigino. https://www.molbiolcell.org/doi/10.1091/mbc.E20-02-0125?ai=25zg&ui=2oy6&af=T


Nutrient sensing/mTOR


Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity – Neeharika Nemani , Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, Karthik Ramachandran, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya SinghMalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Christopher E. Shannon, Warren G. Tourtellotte, Brij B. Singh, W. Brian Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Jonathan Soboloff, Muniswamy Madesh. https://stke.sciencemag.org/content/13/628/eaaz6206

Mitochondrial localization of SESN2 – Irina E Kovaleva, Artem V Tokarchuk, Andrei O Zheltukhin, Alexandra A Dalina, Grigoriy G Safronov, Alexandra G Evstafieva, Konstantin G Lyamzaev, Peter M Chumakov, Andrei V Budanov. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226862

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells – Yeonjin Kim, Mark S. Sundrud, Changqian Zhou, Maja Edenius, Davide Zocco, Kristen Powers, Miao Zhang, Ralph Mazitschek, Anjana Rao, Chang-Yeol Yeo, Erika H. Noss, Michael B. Brenner, Malcolm Whitman, and Tracy L. Keller. https://www.pnas.org/content/117/16/8900.abstract?etoc

The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4 – Thomas D Burton, Anthony O Fedele, Jianling Xie, Lauren Sandeman and Christopher G. Proud. http://www.jbc.org/content/early/2020/04/20/jbc.RA119.011864.abstract

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver – Cédric Gobet, Benjamin Dieter Weger, Julien Marquis, Eva Martin, Nagammal Neelagandan, Frédéric Gachon, and Felix Naef. https://www.pnas.org/content/117/17/9630.abstract?etoc

Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress in Saccharomyces cerevisiae – Imadeddin Hijazi, Jeffrey Knupp and Amy Chang. http://jcs.biologists.org/content/133/6/jcs241539?etoc

A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth – Chase H. Melick, Delong Meng and Jenna L. Jewell. http://www.jbc.org/content/early/2020/04/20/jbc.AC120.012595.abstract


Hypoxia


Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism – Isha H. Jain, Sarah E. Calvo, Andrew L. Markhard, Owen S. Skinner, Tsz-Leung To, Tslil Ast, Vamsi K. Mootha. https://www.cell.com/cell/fulltext/S0092-8674(20)30321-4

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia – Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates III, Sua Myong, John K Kim. https://elifesciences.org/articles/48480

HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α – Peizhan Chen, Xiaohua Duan, Xiaoguang Li, Jingquan Li, Qian Ba and Hui Wang. https://www.nature.com/articles/s41388-020-1190-y


Cancer Immunometabolism


Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages – Pan Su, Qiang Wang, Enguang Bi, Xingzhe Ma, Lintao Liu, Maojie Yang, Jianfei Qian and Qing Yi. https://cancerres.aacrjournals.org/content/80/7/1438

Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy – Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo. https://elifesciences.org/articles/52330

Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment – Prasenjit Dey, Jun Li, Jianhua Zhang, Surendra Chaurasiya, Anders Strom, Huamin Wang, Wen-Ting Liao, Frederick Cavallaro, Parker Denz, Vincent Bernard, Er-Yen Yen, Giannicola Genovese, Pat Gulhati, Jielin Liu, Deepavali Chakravarti, Pingna Deng, Tingxin Zhang, Federica Carbone, Qing Chang, Haoqiang Ying, Xiaoying Shang, Denise J. Spring, Bidyut Ghosh, Nagireddy Putluri, Anirban Maitra, Y. Alan Wang and Ronald A. DePinho. https://cancerdiscovery.aacrjournals.org/content/10/4/608


IDH


Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2 – Ritika Dutta, Tian Yi Zhang, Thomas Köhnke, Daniel Thomas, Miles Linde, Eric Gars, Melissa Stafford, Satinder Kaur, Yusuke Nakauchi, Raymond Yin, Armon Azizi, Anupama Narla, and Ravindra Majeti. https://www.jci.org/articles/view/133344

Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas – Yuxiang Wang , Aaron T. Wild, Sevin Turcan, Wei H. Wu, Carlie Sigel, David S. Klimstra, Xiaoxiao Ma, Yongxing Gong, Eric C. Holland, Jason T. Huse, Timothy A. Chan. https://advances.sciencemag.org/content/6/17/eaaz3221


Miscellaneous


Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis – Katerina Rohlenova, Jermaine Goveia, Melissa García-Caballero, Abhishek Subramanian, Joanna Kalucka, Lucas Treps, Kim D. Falkenberg, Laura P.M.H. de Rooij, Yingfeng Zheng, Lin Lin, Liliana Sokol, Laure-Anne Teuwen, Vincent Geldhof, Federico Taverna, Andreas Pircher, Lena-Christin Conradi, Shawez Khan, Steve Stegen, Dena Panovska, Frederik De Smet, Frank J.T. Staal, Rene J. Mclaughlin, Stefan Vinckier, Tine Van Bergen, Nadine Ectors, Patrik De Haes, Jian Wang, Lars Bolund, Luc Schoonjans, Tobias K. Karakach, Huanming Yang, Geert Carmeliet, Yizhi Liu, Bernard Thienpont, Mieke Dewerchin, Guy Eelen, Xuri Li, Yonglun Luo, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30124-8

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress – Hakjoo Lee, Sylvia B. Smith, Shey-Shing Sheu and Yisang Yoon. https://www.jbc.org/content/early/2020/04/03/jbc.RA119.010983.abstract

Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor – Yejun Zou, Aoxue Wang, Li Huang, Xudong Zhu, Qingxun Hu, Yinan Zhang, Xianjun Chen, Fengwen Li, Qiaohui Wang, Hu Wang, Renmei Liu, Fangting Zuo, Ting Li, Jing Yao, Yajie Qian, Mei Shi, Xiao Yue, Weicai Chen, Zhuo Zhang, Congrong Wang, Yong Zhou, Linyong Zhu, Zhenyu Ju, Joseph Loscalzo, Yi Yang, Yuzheng Zhao. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30144-1

Metabolic Imaging Using Hyperpolarized Pyruvate–Lactate Exchange Assesses Response or Resistance to the EGFR Inhibitor Cetuximab in Patient-Derived HNSCC Xenografts – Lionel Mignion, Stefania Acciardo, Florian Gourgue, Nicolas Joudiou, Xavier Caignet, Rose-Marie Goebbels, Cyril Corbet, Olivier Feron, Caroline Bouzin, Patrice D. Cani, Jean-Pascal Machiels, Sandra Schmitz and Bénédicte F. Jordan. https://clincancerres.aacrjournals.org/content/26/8/1932

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture – Dongqing Zheng, Jonathan H. Sussman, Matthew P. Jeon, Sydney T. Parrish, Melanie A. MacMullan, Alireza Delfarah and Nicholas A. Graham. http://jcs.biologists.org/content/133/7/jcs239277?etoc

GAPDH Delivers Heme to Soluble Guanylyl Cyclase – Yue Dai, Elizabeth A. Sweeny, Simon Schlanger, Arnab Ghosh and Dennis J. Stuehr. http://www.jbc.org/content/early/2020/04/30/jbc.RA120.013802.abstract


Reviews


Metabolic reprogramming and cancer progression – Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis. https://science.sciencemag.org/content/368/6487/eaaw5473

Nitrogen Metabolism in Cancer and ImmunityKiran Kurmi, Marcia C. Haigis. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30040-4 

Metabolic Reprogramming in Tumors: Contributions of the Tumor Microenvironment – Andrew N Lane, Richard M Higashi, Teresa W-M Fan. https://www.sciencedirect.com/science/article/pii/S2352304219300947?via%3Dihub

Enzyme promiscuity, metabolite damage, and metabolite damage control systems of the tricarboxylic acid cycle – Thomas D. Niehaus, Katie B. Hillmann. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15284

The integrated stress response: From mechanism to diseaseMauro Costa-Mattioli, Peter Walter. https://science.sciencemag.org/content/368/6489/eaat5314

A non-proliferative role of pyrimidine metabolism in cancerAarif Siddiqui, Paolo Ceppi. https://www.sciencedirect.com/science/article/pii/S221287782030034X?dgcid=raven_sd_via_email

On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity – Shobbir Hussain. https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30069-8

Seminars in Cell & Developmental Biology special issue: Cancer Cells & Therapeutic Targets – Edited by Massimo Donadelli, Chiara Riganti. https://www.sciencedirect.com/journal/seminars-in-cell-and-developmental-biology/vol/98/suppl/C

Including:

Mitochondrial metabolic alterations in cancer cells and related therapeutic targets

Chiara Riganti, Massimo Donadelli

Regulation of succinate dehydrogenase and role of succinate in cancer

Elisa Dalla Pozza, Ilaria Dando, Raffaella Pacchiana, Elio Liboi, … Marta Palmieri

Fumarate hydratase in cancer: A multifaceted tumour suppressor

Christina Schmidt, Marco Sciacovelli, Christian Frezza

The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?

Houda Abla, Manuela Sollazzo, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Porcelli

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

José M. Matés, Floriana J. Di Paola, José A. Campos-Sandoval, Sybille Mazurek, Javier Márquez 

Role of coenzymes in cancer metabolism

Maheshwor Thapa, Guido Dallmann

Exploiting metabolic vulnerabilities of Non small cell lung carcinoma

Blanca Majem, Ernest Nadal, Cristina Muñoz-Pinedo

Metabolic pathways regulating colorectal cancer initiation and progression

Sofia La Vecchia, Carlos Sebastián

Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness

Marina Bacci, Luigi Ippolito, Lucia Magnelli, Elisa Giannoni, Paola Chiarugi

Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?

Joanna Kopecka, Elena Gazzano, Barbara Castella, Iris C. Salaroglio, … Chiara Riganti

The multifaceted effects of metformin on tumor microenvironment

Ivana Kurelac, Nikkitha Umesh Ganesh, Maria Iorio, Anna Maria Porcelli, Giuseppe Gasparre

3D gastrointestinal models and organoids to study metabolism in human colon cancer

Catarina Silva-Almeida, Marie-Ann Ewart, Colin Wilde

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer diseas

Giovanni Blandino, Fabio Valenti, Andrea Sacconi, Silvia Di Agostino 

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond

Daria Capece, Daniela Verzella, Barbara Di Francesco, Edoardo Alesse, … Francesca Zazzeroni

Autophagy and mitophagy in cancer metabolic remodelling

Fabio Ferro, Stéphane Servais, Pierre Besson, Sébastien Roger, … Lucie Brisson

Mitochondria as playmakers of apoptosis, autophagy and senescence

Marianna Abate, Agostino Festa, Michela Falco, Angela Lombardi, … Gabriella Misso

Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer

Saharnaz Sarlak, Claude Lalou, Nivea Dias Amoedo, Rodrigue Rossignol 

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Alessandro Rimessi, Gaia Pedriali, Bianca Vezzani, Anna Tarocco, … Paolo Pinton

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

Tânia Capelôa, Zohra Benyahia, Luca X. Zampieri, Marine C.N.M. Blackman, Pierre Sonveaux

Targeting metabolic reprogramming in metastatic melanoma: The key role of nicotinamide phosphoribosyltransferase (NAMPT)

Valentina Audrito, Antonella Managò, Federica Gaudino, Silvia Deaglio

Reconciling environment-mediated metabolic heterogeneity with the oncogene-driven cancer paradigm in precision oncology

Catherine Vander Linden, Cyril Corbet

From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer

Sepideh Aminzadeh-Gohari, Daniela D. Weber, Silvia Vidali, Luca Catalano, … René G. Feichtinger


Comments


NADH Ties One-Carbon Metabolism to Cellular Respiration – Adam G. Maynard, Naama Kanarek. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30127-3

Why Warburg Works: Lactate Controls Immune Evasion through GPR81 – Kathrine Lundø, Mette Trauelsen, Stine F. Pedersen, Thue W. Schwartz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30116-9

FABP4: A New Player in Obesity-Associated Breast Cancer – Jun Zeng, Edward R. Sauter, Bing Li. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30076-9

MetaboList – March 2020

 

Research is important. Keep strong everyone

 


Mitochondria


Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway – Xiaoyan Guo, Giovanni Aviles, Yi Liu, Ruilin Tian, Bret A. Unger, Yu-Hsiu T. Lin, Arun P. Wiita, Ke Xu, M. Almira Correia and Martin Kampmann. https://www.nature.com/articles/s41586-020-2078-2

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol – Evelyn Fessler, Eva-Maria Eckl, Sabine Schmitt, Igor Alves Mancilla, Matthias F. Meyer-Bender, Monika Hanf, Julia Philippou-Massier, Stefan Krebs, Hans Zischka and Lucas T. Jae. https://www.nature.com/articles/s41586-020-2076-4

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation – Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger and Helmut Klocker. https://www.nature.com/articles/s41467-020-15237-5

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition – Aurélie Morin, Judith Goncalves, Sophie Moog, Luis-Jaime Castro-Vega, Sylvie Job, Alexandre Buffet, Marie-Joséphine Fontenille, Justine Woszczyk, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Judith Favier. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30329-6

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma – Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath and Mala Shanmugam. https://www.nature.com/articles/s41467-020-15051-z


Nutirent sensing / starvation


Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression – Niklas Mejhert, Leena Kuruvilla, Katlyn R. Gabriel, Shane D. Elliott, Marie-Aude Guie, Huajin Wang, Zon Weng Lai, Elizabeth A. Lane, Romain Christiano, Nika N. Danial, Robert V. Farese Jr., Tobias C. Walther. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30014-9

The role of Rsv1 in the transcriptional regulation of genes involved in sugar metabolism for long‐term survival [yeast] – Eun‐Jung Kim, Yong‐Joon Cho, Woo‐Hyun Chung, Jung‐Hye Roe. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15052

Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1 [yeast] – Triana Amen, Daniel Kaganovich. https://stke.sciencemag.org/content/13/623/eaaz6339

Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restrictionElena Clementi, Larissa Inglin, Erin Beebe, Corina Gsell, Zuzana Garajova and Enni Markkanen. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-020-00771-x 


AMPK / mTOR


Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability – Anders P. Mutvei, Michal J. Nagiec, Jens C. Hamann, Sang Gyun Kim, C. Theresa Vincent and John Blenis. https://www.nature.com/articles/s41467-020-15156-5

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System – Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R. Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30958-X


Cancer Immunometabolism


Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity – Hermans D, Gautam S, García-Cañaveras JC, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin JX, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers LM, Rabinowitz JD, Gattinoni L, Leonard WJ. https://doi.org/10.1073/pnas.1920413117

Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma – Arghya Ray, Yan Song, Ting Du, Dharminder Chauhan and Kenneth C. Anderson. https://www.nature.com/articles/s41388-020-1172-0


Miscellaneous


Metabolic Reprogramming in Cancer Is Induced to Increase Proton Production – Huiyan Sun, Yi Zhou, Michael Francis Skaro, Yiran Wu, Zexing Qu, Fenglou Mao, Suwen Zhao and Ying Xu. https://cancerres.aacrjournals.org/content/80/5/1143

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPCRobinson Arce-Molina, Francisca Cortés-Molina, Pamela Y Sandoval, Alex Galaz, Karin Alegría, Stefanie Schirmeier, L Felipe Barros, Alejandro San Martín. https://elifesciences.org/articles/53917

Metabolites released from apoptotic cells act as tissue messengers – Christopher B. Medina, Parul Mehrotra, Sanja Arandjelovic, Justin S. A. Perry, Yizhan Guo, Sho Morioka, Brady Barron, Scott F. Walk, Bart Ghesquière, Alexander S. Krupnick, Ulrike Lorenz and Kodi S. Ravichandran. https://www.nature.com/articles/s41586-020-2121-3


Glucose metabolism


Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion – R. Commander, C. Wei, A. Sharma, J. K. Mouw, L. J. Burton, E. Summerbell, D. Mahboubi, R. J. Peterson, J. Konen, W. Zhou, Y. Du, H. Fu, M. Shanmugam and A. I. Marcus. https://www.nature.com/articles/s41467-020-15219-7

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer – Qingjian Li, Tao Qin, Zhuofei Bi, Huangming Hong, Lin Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Man-Li Luo, Phei Er Saw, Gerburg M. Wulf, Xiaoding Xu, Erwei Song, Herui Yao and Hai Hu. https://www.nature.com/articles/s41467-020-15308-7

Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2Suparno Nandi and Mishtu Dey. http://www.jbc.org/content/early/2020/03/06/jbc.RA120.013030.abstract 

Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis – Yun-feng Guan, Qiao-ling Huang, Yuan-li Ai, Qi-tao Chen, Wen-xiu Zhao, Xiao-min Wang, Qiao Wu and Hang-zi Chen. https://www-nature-com.sire.ub.edu/articles/s41388-020-1158-y


PFKFB3


Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3 – Andrew J. Robinson, Goitseone L. Hopkins, Namrata Rastogi, Marie Hodges, Michelle Doyle, Sara Davies, Paul S. Hole, Nader Omidvar, Richard L. Darley and Alex Tonks. https://cancerres.aacrjournals.org/content/80/5/937

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3 – Huanhuan Ma, Jia Zhang, Lin Zhou, Shixiong Wen, Hsiang-Yu Tang, Bin Jiang, Fengqiong Zhang, Muhammad Suleman, Dachao Sun, Ai Chen, Wentao Zhao, Furong Lin, Ming-Tong Tsau, Lu-Min Shih, Changchuan Xie, Xiaotong Li, Donghai Lin, Li-Man Hung, Mei-Ling Cheng, Qinxi Li. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30303-X

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming – Jia Liu, Ze-Xian Liu, Qi-Nian Wu, Yun-Xin Lu, Chau-Wei Wong, Lei Miao, Yun Wang, Zixian Wang, Ying Jin, Ming-Ming He, Chao Ren, De-Shen Wang, Dong-Liang Chen, Heng-Ying Pu, Lin Feng, Bo Li, Dan Xie, Mu-Sheng Zeng, Peng Huang, Aifu Lin, Dongxin Lin, Rui-Hua Xu and Huai-Qiang Ju. https://www.nature.com/articles/s41467-020-15112-3


Glutamine metabolism and restriction


A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer – Manabu Kodama, Kiyotaka Oshikawa, Hideyuki Shimizu, Susumu Yoshioka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Chisa Tateishi, Takeshi Tomonaga, Masaki Matsumoto and Keiichi I. Nakayama. https://www.nature.com/articles/s41467-020-15136-9

Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma – L. Ren, V. Ruiz-Rodado, T. Dowdy, S. Huang, S. H. Issaq, J. Beck, H. Wang, C. Tran Hoang, A. Lita, M. Larion and A. K. LeBlanc. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-0209-8

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers – Suman Mukhopadhyay, Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin, Serguei V. Kozlov, Dwight V. Nissley and Frank McCormick. https://cancerres.aacrjournals.org/content/early/2020/02/23/0008-5472.CAN-19-1363

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer – Thai Q. Tran, Eric A. Hanse, Amber N. Habowski, Haiqing Li, Mari B. Ishak Gabra, Ying Yang, Xazmin H. Lowman, Amelia M. Ooi, Shu Y. Liao, Robert A. Edwards, Marian L. Waterman and Mei Kong. https://www.nature.com/articles/s43018-020-0035-5


Other amino acids


Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism – Albert M. Li, Gregory S. Ducker, Yang Li, Jose A. Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E. Graves, Erinn B. Rankin, Christina Curtis, Joan Massagué, Joshua D. Rabinowitz, Craig B. Thompson, Jiangbin Ye. https://mcr.aacrjournals.org/content/early/2020/01/15/1541-7786.MCR-19-0606

Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells – Białopiotrowicz E, Noyszewska-Kania M, Kachamakova-Trojanowska N, Łoboda A, Cybulska M, Grochowska A, Kopczyński M, Mikula M, Prochorec-Sobieszek M, Firczuk M, Graczyk-Jarzynka A, Zagożdżon R, Ząbek A, Młynarz P, Dulak J, Górniak P, Szydłowski M, Pyziak K, Martyka J, Sroka-Porada A, Jabłońska E, Polak A, Kowalczyk P, Szumera-Ciećkiewicz A, Chapuy B, Rzymski T, Brzózka K, Juszczyński P. https://doi.org/10.3390/cancers12030580

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma – Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W. https://link.springer.com/article/10.1007%2Fs00018-020-03483-1

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy – Renee C. Geck, Jackson R. Foley, Tracy Murray Stewart, John M. Asara, Robert A. Casero Jr. and Alex Toker. http://www.jbc.org/content/early/2020/03/05/jbc.RA119.012376.abstract

Cancer progression is mediated by proline catabolism in non-small cell lung cancer – Yating Liu, Chao Mao, Min Wang, Na Liu, Lianlian Ouyang, Shouping Liu, Haosheng Tang, Ya Cao, Shuang Liu, Xiang Wang, Desheng Xiao, Ceshi Chen, Ying Shi, Qin Yan & Yongguang Tao. https://www.nature.com/articles/s41388-019-1151-5


Lipid metabolism


Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells – Emily Clement, Ikrame Lazar, Camille Attané, Lorry Carrié, Stéphanie Dauvillier, Manuelle Ducoux‐Petit, David Esteve, Thomas Menneteau, Mohamed Moutahir, Sophie Le Gonidec, Stéphane Dalle, Philippe Valet, Odile Burlet‐Schiltz, Catherine Muller, Laurence Nieto. https://www.embopress.org/doi/abs/10.15252/embj.2019102525

Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma – Elizabeth C. Randall, Begoña G.C. Lopez, Sen Peng, Michael S. Regan, Walid M. Abdelmoula, Sankha S. Basu, Sandro Santagata, Haejin Yoon, Marcia C. Haigis, Jeffrey N. Agar, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria and Nathalie Y.R. Agar. https://cancerres.aacrjournals.org/content/80/6/1258

The MEK5–ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer – Sandra Cristea, Garry L. Coles, Daniel Hornburg, Maya Gershkovitz, Julia Arand, Siqi Cao, Triparna Sen, Stuart C. Williamson, Jun W. Kim, Alexandros P. Drainas, Andrew He, Laurent Le Cam, Lauren Averett Byers, Michael P. Snyder, Kévin Contrepois and Julien Sage. https://cancerres.aacrjournals.org/content/80/6/1293

Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis – Li Gu, Yahui Zhu, Xi Lin, Xingyu Tan, Bingjun Lu and Youjun Li. https://www.nature.com/articles/s41388-020-1156-0


Nucleotides and NADPH


MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis – Chien-Kuang Cornelia Ding, Joshua Rose, Tianai Sun, Jianli Wu, Po-Han Chen, Chao-Chieh Lin, Wen-Hsuan Yang, Kai-Yuan Chen, Hana Lee, Emily Xu, Sarah Tian, Jadesola Akinwuntan, Jinshi Zhao, Ziqiang Guan, Pei Zhou and Jen-Tsan Chi. https://www.nature.com/articles/s42255-020-0181-1

Macropinocytosis confers resistance to therapies targeting cancer anabolism – Vaishali Jayashankar and Aimee L. Edinger. https://www.nature.com/articles/s41467-020-14928-3

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors – Sona Hubackova, Eliska Davidova, Stepana Boukalova, Jaromira Kovarova, Martina Bajzikova, Ana Coelho, Mikkel G. Terp, Henrik J. Ditzel, Jakub Rohlena and Jiri Neuzil. https://www.nature.com/articles/s41419-020-2224-7

UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism – Xing Feng, Dong Ma, Jiabao Zhao, Yongxi Song, Yuekun Zhu, Qingxin Zhou, Fei Ma, Xing Liu, Mengya Zhong, Yu Liu, Yubo Xiong, Xingfeng Qiu, Zhen Zhang, Heng Zhang, Yongxiang Zhao, Kaiguang Zhang, Xuehui Hong, Zhiyong Zhang. https://www.embopress.org/doi/abs/10.15252/embj.2019102541


Hypoxia / pseudohypoxia


TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition – Aurélie Morin, Judith Goncalves, Sophie Moog, Luis-Jaime Castro-Vega, Sylvie Job, Alexandre Buffet, Marie-Joséphine Fontenille, Justine Woszczyk, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Judith Favier. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30329-6

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia – Yang Li, Joshua J. Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Lori S. Hart, John M. Maris, Howard Y. Chang, Amato J. Giaccia, Jiangbin Ye. https://www.nature.com/articles/s41419-020-2303-9


Reviews


Dietary modifications for enhanced cancer therapyNaama Kanarek, Boryana Petrova and David M. Sabatini. https://www.nature.com/articles/s41586-020-2124-0 

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer – Benjamin D. Hopkins, Marcus D. Goncalves and Lewis C. Cantley. https://www.nature.com/articles/s41574-020-0329-9

The PHGDH enigma: do cancer cells only need serine or also a redox modulator? – Albert M. Li and Jiangbin Ye. https://www.sciencedirect.com/science/article/pii/S0304383520300501

Ketogenic diet in the treatment of cancer – Where do we stand?Daniela D. Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G. Feichtinger, Barbara Kofler. https://www.sciencedirect.com/science/article/pii/S2212877819304272 

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control – Asier González, Michael N. Hall, Sheng-Cai Lin, D. Grahame Hardie. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30058-9

mTOR Regulation of Metabolism in Hematologic MalignanciesSimone Mirabilii, Maria Rosaria Ricciardi and Agostino Tafuri. https://www.mdpi.com/2073-4409/9/2/404

Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen – Safak Bayram, Susanne Fürst, Martin Forbes, Stefan Kempa. https://www.sciencedirect.com/science/article/pii/S2212877819309536

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer – Matthieu Lacroix, Romain Riscal, Giuseppe Arena, Laetitia Karine Linares, Laurent Le Cam. https://www.sciencedirect.com/science/article/pii/S2212877819309214

Formate metabolism in health and disease – Matthias Pietzke, Johannes Meiser, Alexei Vazquez. https://www.sciencedirect.com/science/article/pii/S2212877819304314

Monocarboxylate transporters in cancerValéry L. Payen, Erica Mina, Vincent F. Van Hée, Paolo E. Porporato, Pierre Sonveaux. https://www.sciencedirect.com/science/article/pii/S221287781930403X 

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion – Peter Kreuzaler, Yulia Panina, Joanna Segal, Mariia Yuneva. https://www.sciencedirect.com/science/article/pii/S2212877819309068

IGFBP2: integrative hub of developmental and oncogenic signaling network – Tao Li, M. Elizabeth Forbes, Gregory N. Fuller, Jiabo Li, Xuejun Yang and Wei Zhang. https://www.nature.com/articles/s41388-020-1154-2

mTOR at the nexus of nutrition, growth, ageing and disease – Grace Y. Liu and David M. Sabatini. https://www.nature.com/articles/s41580-019-0199-y


Comments


Restraining colorectal cancer with αKG – Dana Krauß and Eyal Gottlieb. https://www.nature.com/articles/s43018-020-0044-4

Ghostly metabolic messages from dying cells – Douglas R. Green. https://www.nature.com/articles/d41586-020-00641-0

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved! – Massimo M.Santoro. https://www.sciencedirect.com/science/article/abs/pii/S1550413119306722

Cancer metabolism – An updateAlmut Schulze. https://www.sciencedirect.com/science/article/pii/S2212877819309494 

Appetite for Arginine: Metabolic Control of Macrophage Hunger – Daniel J. Puleston, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30064-4

Metabolite Imaging at the Margin: Visualizing Metabolic Tumor Gradients Using Mass Spectrometry – Ai Wen Tan and Aalim M. Weljie. https://cancerres.aacrjournals.org/content/80/6/1231

Mitochondrial distress call moves to the cytosol to trigger a response to stress – Bradford P. Tremblay and Cole M. Haynes. https://www.nature.com/articles/d41586-020-00552-0

A new adaptation strategy to glucose starvation: modulation of the gluconate shunt and pentose phosphate pathway by the transcriptional repressor Rsv1Rodrigo Fraile, Laura Sánchez‐Mir, Elena Hidalgo. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15131 

Trimming the “fatty” intratumoral Tregs for cancer immunotherapy – Lewis Z. Shi. https://stm.sciencemag.org/content/12/534/eabb2770

Stress fibres fuel glycolysis – Joseph Willson. https://www.nature.com/articles/s41580-020-0224-1

MetaboList – February 2020

 


Glucose metabolism


Mechanical regulation of glycolysis via cytoskeleton architecture – Jin Suk Park, Christoph J. Burckhardt, Rossana Lazcano, Luisa M. Solis, Tadamoto Isogai, Linqing Li, Christopher S. Chen, Boning Gao, John D. Minna, Robert Bachoo, Ralph J. DeBerardinis and Gaudenz Danuser. https://www.nature.com/articles/s41586-020-1998-1

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy – Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30054-1

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway – Michael M. Dubreuil, David W. Morgens, Kanji Okumoto, Masanori Honsho, Kévin Contrepois, Brittany Lee-McMullen, Gavin McAllister Traber, Ria S. Sood, Scott J. Dixon, Michael P. Snyder, Yukio Fujiki, Michael C. Bassik. https://www.sciencedirect.com/science/article/pii/S221112472030022X

Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway – Caihong Wang, Shaosen Zhang, Jie Liu, Yang Tian, Boyuan Ma, Siran Xu, Yan Fu, Yongzhang Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30052-8

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing – Lili Yu, Jinchul Kim, Lei Jiang, Bingbing Feng, Yue Ying, Kai-yuan Ji, Qingshuang Tang, Wancheng Chen, Taoyi Mai, Wenlong Dou, Jianlong Zhou, Le-yang Xiang, Yang-fan He, Dinghua Yang, Qingjiao Li, Xuemei Fu and Yang Xu. https://www.nature.com/articles/s41467-020-14437-3

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis – Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann and Martin S. Denzel. https://www.nature.com/articles/s41467-020-14524-5

GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling – Wen-Lian Chen, Xing Jin, Mingsong Wang, Dan Liu, Qin Luo, Hechuan Tian, Lili Cai, Lifei Meng, Rui Bi, Lei Wang, Xiao Xie, Guanzhen Yu, Lihui Li, Changsheng Dong, Qiliang Cai, Wei Jia, Wenyi Wei and Lijun Jia. https://insight.jci.org/articles/view/131596#

CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells – Samantha Ames, Jacob T. Andring, Robert McKenna and Holger M. Becker. https://www.nature.com/articles/s41388-019-1098-6


ROS / Amino acids


Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids – Sarah E. LeBoeuf, Warren L. Wu, Triantafyllia R. Karakousi, Burcu Karadal, S. RaElle Jackson, Shawn M. Davidson, Kwok-Kin Wong, Sergei B. Koralov, Volkan I. Sayin, Thales Papagiannakopoulos. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30619-9

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer – Eric C. Cheung, Gina M. DeNicola, Colin Nixon, Karen Blyth, Christiaan F. Labuschagne, David A. Tuveson, Karen H. Vousden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30582-3


Lipid metabolism


Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis  – Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi and Hei Sook Sul. https://www.nature.com/articles/s41467-020-14617-1

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects – Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes. https://www.pnas.org/content/117/8/4158.abstract?etoc


Mitochondria


Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier – Claire L. Bensard, Dona R. Wisidagama, Kristofor A. Olson, Jordan A. Berg, Nathan M. Krah, John C. Schell, Sara M. Nowinski, Sarah Fogarty, Alex J. Bott, Peng Wei, Katja K. Dove, Jason M. Tanner, Vanja Panic, Ahmad Cluntun, Sandra Lettlova, Christian S. Earl, David F. Namnath, Karina Vázquez-Arreguín, Claudio J. Villanueva, Dean Tantin, L. Charles Murtaugh, Kimberley J. Evason, Gregory S. Ducker, Carl S. Thummel, Jared Rutter. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30609-6

A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism – Jiujie Cui, Ming Quan, Dacheng Xie, Yong Gao, Sushovan Guha, Michael B. Fallon, Jingde Chen and Keping Xie. https://www.nature.com/articles/s41388-019-1051-8

The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation – Marciano R, David HB, Akabayov B, Rotblat B. https://www.mdpi.com/1422-0067/21/3/1041


Starvation / AMPK


Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease – Fan Jia, Congwu Chi, Min Han. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30075-9

Energy-stress-mediated AMPK activation inhibits ferroptosis – Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell and Boyi Gan. https://www.nature.com/articles/s41556-020-0461-8

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise – Yang Liu, Phong T. Nguyen, Xun Wang, Yuting Zhao, Corbin E. Meacham, Zhongju Zou, Bogdan Bordieanu, Manuel Johanns, Didier Vertommen, Tobias Wijshake, Herman May, Guanghua Xiao, Sanae Shoji-Kawata, Mark H. Rider, Sean J. Morrison, Prashant Mishra and Beth Levine. https://www.nature.com/articles/s41586-020-1992-7


mTOR


Glutamine and asparagine activate mTORC1 independently of Rag GTPases – Delong Meng, Qianmei Yang, Huanyu Wang, Chase H. Melick, Rishika Navlani, Anderson R. Frank and Jenna L. Jewell. http://www.jbc.org/content/early/2020/02/04/jbc.AC119.011578.abstract

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control – Wenjian Gan, Xiaoming Dai, Xiangpeng Dai, Jun Xie, Shasha Yin, Junjie Zhu, Chen Wang, Yuchen Liu, Jianping Guo, Min Wang, Jing Liu, Jia Hu, Ryan J. Quinton, Neil J. Ganem, Pengda Liu, John M. Asara, Pier Paolo Pandolfi, Yingzi Yang, Zhigang He, Guangping Gao and Wenyi Wei. https://www.nature.com/articles/s41556-020-0463-6

DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals – Xiaoyu Chen, Xiufang Xiong, Danrui Cui, Fei Yang, Dongping Wei, Haomin Li, Jianfeng Shu, Yanli Bi, Xiaoqing Dai, Longyuan Gong, Yi Sun and Yongchao Zhao. https://www.nature.com/articles/s41388-019-1085-y

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition – Evdokia Michalopoulou, Francesca R. Auciello, Vinay Bulusu, David Strachan, Andrew D. Campbell, Jacqueline Tait-Mulder, Saadia A. Karim, Jennifer P. Morton, Owen J. Sansom, Jurre J. Kamphorst. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30105-4


Hypoxia


NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC – Prashant V. Bommi, Vaibhav Chand, Nishit K. Mukhopadhyay, Pradip Raychaudhuri and Srilata Bagchi. https://www.nature.com/articles/s41388-019-1105-y


Metformin, phenformin


GDF15 mediates the effects of metformin on body weight and energy balance – Anthony P. Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John A. Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A. Goldspink, Emily L. Miedzybrodzka, Adam R. Konopka, Raul Ruiz Esponda, Jeffrey T.-J. Huang, Y. C. Loraine Tung, Sergio Rodriguez-Cuenca, Rute A. Tomaz, Heather P. Harding, Audrey Melvin, Giles S. H. Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, K. Sreekumaran Nair, Nicholas J. Wareham, David Ron, Fiona M. Gribble, Frank Reimann, Naveed Sattar, David B. Savage, Bernard B. Allan and Stephen O’Rahilly. https://www.nature.com/articles/s41586-019-1911-y

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module – Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30033-4

Metformin Abrogates Age-Associated Ovarian Fibrosis – Curtis W. McCloskey, David P. Cook, Brendan S. Kelly, Feryel Azzi, Christian H. Allen, Amanda Forsyth, Jeremy Upham, Katey J. Rayner, Douglas A. Gray, Robert W. Boyd, Sangeeta Murugkar, Bryan Lo, Dominique Trudel, Mary K. Senterman and Barbara C. Vanderhyden. https://clincancerres.aacrjournals.org/content/26/3/632


Cancer Immunometabolism


CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors – Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius and Ping-Chih Ho. https://www.nature.com/articles/s41590-019-0589-5

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade – Daniel Ajona, Sergio Ortiz-Espinosa, Teresa Lozano, Francisco Exposito, Alfonso Calvo, Karmele Valencia, Miriam Redrado, Ana Remírez, Fernando Lecanda, Diego Alignani, Juan J. Lasarte, Irati Macaya, Yaiza Senent, Cristina Bértolo, Cristina Sainz, Ignacio Gil-Bazo, Iñaki Eguren-Santamaría, Jose M. Lopez-Picazo, Alvaro Gonzalez, Jose L. Perez-Gracia, Carlos E. de Andrea, Silvestre Vicent, Miguel F. Sanmamed, Luis M. Montuenga and Ruben Pio. https://www.nature.com/articles/s43018-019-0007-9

Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s – Marek Wagner, Kafi N. Ealey, Hiroe Tetsu, Tsuyoshi Kiniwa, Yasutaka Motomura, Kazuyo Moro, Shigeo Koyasu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30137-6


Reviews


Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer – Sharanya Sivanand, Matthew G. Vander Heiden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30581-1?dgcid=raven_jbs_etoc_email

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo – Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30263-4

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis – Guido T. Bommer, Emile Van Schaftingen, Maria Veiga-da-Cunha. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30176-8

Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment? – Ainhoa Madariaga, Pamela J. Goodwin and Amit M. Oza. https://clincancerres.aacrjournals.org/content/26/3/523

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism – Jonathan J. Ruprecht, Edmund R.S. Kunji. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30229-4

Cell cycle regulators in cancer cell metabolism – Leal-Esteban LC, Fajas L. https://www.sciencedirect.com/science/article/abs/pii/S0925443920300600

Mitochondrial functions and rare diseases – L.Dard, W.Blanchard, C.Hubert, D.Lacombe, R.Rossignol. https://www.sciencedirect.com/science/article/pii/S0098299719301177

Mechanistic Links between Obesity, Insulin, and Cancer – Rachel J. Perry, Gerald I. Shulman. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30261-4

Metabolic Regulation of Cell Fate and Function – Shohini Ghosh-Choudhary, Jie Liu, Toren Finkel. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30219-3

Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma – Erhu Zhao, Jianbing Hou and Hongjuan Cui. https://www.nature.com/articles/s41389-020-0200-9

Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities – Binlu Huang, Bao-liang Song and Chenqi Xu. https://www.nature.com/articles/s42255-020-0174-0


Comments


We need to talk about the Warburg effect – Ralph J. DeBerardinis and Navdeep S. Chandel. https://www.nature.com/articles/s42255-020-0172-2

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects – Sarah-Maria Fendt, Sophia Y. Lunt. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30048-9

Dietary Methionine in T Cell Biology and Autoimmune Disease – Shuang Tang, Xiaoling Li, Jason W. Locasale. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30007-3

Glucose Starvation Blocks Translation at Multiple Levels – Chen-Song Zhang, D. Grahame Hardie, Sheng-Cai Lin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30005-X

Tension in tumour cells keeps metabolism high – Nadia M. E. Ayad, Valerie M. Weaver. https://www.nature.com/articles/d41586-020-00314-y

Histone Lactylation: A New Role for Glucose Metabolism – Maria V. Liberti, Jason W. Locasale. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30265-8

Surviving stress during metastasis – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-0243-4

Starving tumours – Anna Dart. https://www.nature.com/articles/s41568-020-0244-3

Mechanosensing metabolically moves cancer cells – Wei Wong. https://stke.sciencemag.org/content/13/619/eabb2935

An SLC1A5 Variant Transports Glutamine to Mitochondria in Cancer Cells – https://cancerdiscovery.aacrjournals.org/content/10/2/173.2

Isoform-Specific KRAS–Hexokinase 1 Interaction Affects Metabolism – https://cancerdiscovery.aacrjournals.org/content/10/2/OF10

MetaboList – January 2020

 


Starvation / nutrient sensing


Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 – Ina Yoon, Miso Nam, Hoi Kyoung Kim, Hee-Sun Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, Seongmin Cho, YounHa Kim, Jihye Lee, Won Suk Yang, Hee Chan Yoo, Kibum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, Geum-Sook Hwang, Kwang Yeon Hwang, Jung Min Han, Jong Hyun Kim, Sunghoon Kim. https://science.sciencemag.org/content/367/6474/205

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy – Maximilian Schütter, Patrick Giavalisco, Susanne Brodesser, Martin Graef. https://www.cell.com/cell/fulltext/S0092-8674(19)31331-5

Glucose stimulates microRNA-199 expression in murine pancreatic β-cells – Joao Pedro Werneck-de-Castro, Manuel Blandino-Rosano, Denise Hilfiker-Kleiner and Ernesto Bernal-Mizrachi. http://www.jbc.org/content/early/2019/12/26/jbc.RA119.010356.abstract

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila – Kenneth Kin Lam Wong, Ta-Wei Liu, Jessica M. Parker, Donald A. R. Sinclair, Yi-Yun Chen, Kay-Hooi Khoo, David J. Vocadlo and Esther M. Verheye.
https://www.pnas.org/content/117/4/2004.abstract?etoc


mTOR


Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs – Dritan Liko, Andrzej Rzepiela, Vanja Vukojevic, Mihaela Zavolan and Michael N. Hall. https://www.pnas.org/content/117/3/1524.abstract?etoc

Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria – Eisha Shaw, Manasi Talwadekar, Zeenat Rashida, Nitya Mohan, Aishwarya Acharya, Subhash Khatri, Sunil Laxman and Ullas Kolthur-Seetharam. http://mcb.asm.org/content/40/2/e00212-19.abstract?etoc

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation – Ying-Nan Wang, Yun-Xin Lu, Jie Liu, Ying Jin, Hui-Chang Bi, Qi Zhao, Ze-Xian Liu, Ying-Qin Li, Jia-Jia Hu, Hui Sheng, Yi-Ming Jiang, Chao Zhang, Feng Tian, Yang Chen, Zhi-Zhong Pan, Gong Chen, Zhao-Lei Zeng, Kai-Yan Liu, Marcia Ogasawara, Jin-Ping Yun, Huai-Qiang Ju, Jian-Xiong Feng, Dan Xie, Song Gao, Wei-Hua Jia, Scott Kopetz, Rui-Hua Xu and Feng Wang. https://www.nature.com/articles/s41388-019-1004-2

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress – Naomi X. Y. Ling, Adrian Kaczmarek, Ashfaqul Hoque, Elizabeth Davie, Kevin R. W. Ngoei, Kaitlin R. Morrison, William J. Smiles, Gabriella M. Forte, Tingting Wang, Shervi Lie, Toby A. Dite, Christopher G. Langendorf, John W. Scott, Jonathan S. Oakhill and Janni Petersen. https://www.nature.com/articles/s42255-019-0157-1

A two-pore channel protein required for regulating mTORC1 activity on starvation – Fu-Sheng Chang, Yuntao Wang, Phillip Dmitriev, Julian Gross, Antony Galione and Catherine Pears [Dictyostelium]. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0735-4

Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis – Pengfei Cao, Sang-Jin Kim, Anqi Xing, Craig A Schenck, Lu Liu, Nan Jiang, Jie Wang, Robert L Last, Federica Brandizzi. https://elifesciences.org/articles/50747


Glucose metabolism


Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy – Nikita S. Sharma, Vineet K. Gupta, Vanessa T. Garrido, Roey Hadad, Brittany C. Durden, Kousik Kesh, Bhuwan Giri, Anthony Ferrantella, Vikas Dudeja, Ashok Saluja and Sulagna Banerjee. https://www.jci.org/articles/view/127515

A synthetic lethal drug combination mimics glucose deprivation-induced cancer cell death in the presence of glucose – James H Joly, Alireza Delfarah, Philip S Phung, Sydney Parrish and Nicholas A. Graham. http://www.jbc.org/content/early/2019/12/30/jbc.RA119.011471.abstract

O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth – Jay Prakash Singh, Kevin Qian, Jeong-Sang Lee, Jinfeng Zhou, Xuemei Han, Bichen Zhang, Qunxiang Ong, Weiming Ni, Mingzuo Jiang, Hai-Bin Ruan, Min-Dian Li, Kaisi Zhang, Zhaobing Ding, Philip Lee, Kamini Singh, Jing Wu, Raimund I. Herzog, Susan Kaech, Hans-Guido Wendel, John R. Yates III, Weiping Han, Robert S. Sherwin, Yongzhan Nie and Xiaoyong Yang. https://www.nature.com/articles/s41388-019-0975-3

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1 – Kristin L. Granlund, Sui-Seng Tee, Hebert A. Vargas, Serge K. Lyashchenko, Ed Reznik, Samson Fine, Vincent Laudone, James A. Eastham, Karim A. Touijer, Victor E. Reuter, Mithat Gonen, Ramon E. Sosa, Duane Nicholson, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb, Hedvig Hricak, Kayvan R. Keshari. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30498-X


Amino acids


Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy – Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl and Costas A. Lyssiotis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0202-2

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells – Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez and Sophia Y. Lunt. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0205-z

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy – Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero Jr. and Dominic J. Smiraglia. https://www.nature.com/articles/s41467-019-13950-4

Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine – Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Keisuke Kawasaki, Yumiko Hori, Moyu Taniguchi, Yutaka Umakoshi, Daisuke Okuzaki, Naoki Wada, Jun-ichiro Ikeda, Eiichiro Fukusaki and Eiichi Morii. https://www.nature.com/articles/s42255-019-0156-2


Lipid metabolism / Statins


Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress – Irem Kaymak, Carina R. Maier, Werner Schmitz, Andrew D. Campbell, Beatrice Dankworth, Carsten P. Ade, Susanne Walz, Madelon Paauwe, Charis Kalogirou, Hecham Marouf, Mathias T. Rosenfeldt, David M. Gay, Grace H. McGregor, Owen J. Sansom and Almut Schulze. https://cancerres.aacrjournals.org/content/80/2/189

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response – Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J. Sansom and Jurre J. Kamphorst. https://cancerres.aacrjournals.org/content/80/2/175

Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer – Joanna M. Karasinska, James T. Topham, Steve E. Kalloger, Gun Ho Jang, Robert E. Denroche, Luka Culibrk, Laura M. Williamson, Hui-Li Wong, Michael K.C. Lee, Grainne M. O’Kane, Richard A. Moore, Andrew J. Mungall, Malcolm J. Moore, Cassia Warren, Andrew Metcalfe, Faiyaz Notta, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf and David F. Schaeffer. https://clincancerres.aacrjournals.org/content/26/1/135

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer – Jessica C. Casciano, Caroline Perry, Adam J. Cohen-Nowak, Katelyn D. Miller, Johan Vande Voorde, Qifeng Zhang, Susan Chalmers, Mairi E. Sandison, Qin Liu, Ann Hedley, Tony McBryan, Hsin-Yao Tang, Nicole Gorman, Thomas Beer, David W. Speicher, Peter D. Adams, Xuefeng Liu, Richard Schlegel, John G. McCarron, Michael J. O. Wakelam, Eyal Gottlieb, Andrew V. Kossenkov and Zachary T. Schug. https://www.nature.com/articles/s41416-019-0711-3

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response – Yagmur Micoogullari, Sankha S. Basu, Jessie Ang, Nina Weisshaar, Nicholas D. Schmitt, Walid M. Abdelmoula, Begona Lopez, Jeffrey N. Agar, Nathalie Agar and John Hanna. https://www.molbiolcell.org/doi/10.1091/mbc.E19-07-0392?ai=s5&ui=2oy6&af=T

Deciphering the Elevated Lipid via CD36 in Mantle Cell Lymphoma with Bortezomib Resistance Using Synchrotron-Based Fourier Transform Infrared Spectroscopy of Single Cells – Sudjit Luanpitpong ,Montira Janan ,Kanjana Thumanu , Jirarat Poohadsuan ,Napachai Rodboon , Phatchanat Klaihmon and Surapol Issaragrisil. https://doi.org/10.3390/cancers11040576


Mitochondria


A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells – Hee Chan Yoo, Seung Joon Park, Miso Nam, Juwon Kang, Kibum Kim, Joo Hye Yeo, Joon-Ki Kim, Yunkyung Heo, Hee Seung Lee, Myeong Youl Lee, Chang Woo Lee, Jong Soon Kang, Yun-Hee Kim, Jinu Lee, Junjeong Choi, Geum-Sook Hwang, Seungmin Bang, Jung Min Han. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30664-3

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth – Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan and Wen Yi. https://www.nature.com/articles/s41467-019-13601-8

Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway – Yu Liang, Lidan Hou, Linjing Li, Lei Li, Liming Zhu, Yu Wang, Xin Huang, Yichao Hou, Danxi Zhu, Huimin Zou, Yan Gu, Xiaoling Weng, Yingying Wang, Yue Li, Tianqi Wu, Mengfei Yao, Isabelle Gross, Christian Gaiddon, Meng Luo, Jianhua Wang and Xiangjun Meng. https://www.nature.com/articles/s41388-019-1035-8


Cancer Immunometabolism


Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage – Evi Goulielmaki, Anna Ioannidou, Maria Tsekrekou, Kalliopi Stratigi, Ioanna K. Poutakidou, Katerina Gkirtzimanaki, Michalis Aivaliotis, Konstantinos Evangelou, Pantelis Topalis, Janine Altmüller, Vassilis G. Gorgoulis, Georgia Chatzinikolaou and George A. Garinis. https://www.nature.com/articles/s41467-019-13894-9


Miscellaneous


Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism – Sophie Trefely, JoyceLiu, Katharina Huber, Mary T. Doan, Helen Jiang, Jay Singh, Elianavon Krusenstiern, Anna Bostwick, Peining Xu, Juliane G.Bogner-Strauss, Kathryn E. Wellen, Nathaniel W.Snyder. https://www.sciencedirect.com/science/article/pii/S221287781930907X

Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer – Youngtae Jeong, Jessica A. Hellyer, Henning Stehr, Ngoc T. Hoang, Xiaomin Niu, Millie Das, Sukhmani K. Padda, Kavitha Ramchandran, Joel W. Neal, Heather Wakelee and Maximilian Diehn. https://clincancerres.aacrjournals.org/content/26/1/274

The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis – Vassilis Papalazarou, Tong Zhang, Nikki R. Paul, Amelie Juin, Marco Cantini, Oliver D. K. Maddocks, Manuel Salmeron-Sanchez and Laura M. Machesky. https://www.nature.com/articles/s42255-019-0159-z

Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma – Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D. Tap, Nicola Fabbri, Edward Athanasian, Patrick J. Boland, John H. Healey, Michael F. Berger, Marc Ladanyi and Meera Hameed. https://clincancerres.aacrjournals.org/content/26/2/419


Reviews


The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism – Gerta Hoxhaj and Brendan D. Manning. https://www.nature.com/articles/s41568-019-0216-7

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer – Marteinn Thor Snaebjornsson, Sudha Janaki-Raman, Almut Schulze. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30617-5

Targeting Extracellular Nutrient Dependencies of Cancer Cells – Javier Garcia-Bermudez, Robert T Williams, Rohiverth Guarecuco, Kıvanç Birsoy. https://www.sciencedirect.com/science/article/pii/S2212877819309433

The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology – Catherine J. Libby, Jonathan McConathy, Victor Darley-Usmar and Anita B. Hjelmeland. https://cancerres.aacrjournals.org/content/80/1/5

Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer – Kamiya Mehla and Pankaj K. Singh. https://clincancerres.aacrjournals.org/content/26/1/6

Tumor microenvironment differences between primary tumor and brain metastases – Cacho-Díaz B, García-Botello DR, Wegman-Ostrosky T, Reyes-Soto G, Ortiz-Sánchez E, Herrera-Montalvo LA. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-02189-8

Targeting citrate as a novel therapeutic strategy in cancer treatment – Lan Huang, Cindy Wang, Huaxi Xu, Guangyong Peng. https://www.sciencedirect.com/science/article/pii/S0304419X19301593

Dietary patterns and cancer risk – Susan E. Steck and E. Angela Murphy
https://www.nature.com/articles/s41568-019-0227-4

Loads of reviews and primary articles at the special issue in Cancers:
“Metabolic Reprogramming and Vulnerabilities in Cancer” – Guest Editor(s): Deepak Nagrath, Costas Lyssiotis. https://www.mdpi.com/journal/cancers/special_issues/metabolic-reprogram

Including:

Hodakoski, C.; Hopkins, B.D.; Zhang, G.; Su, T.; Cheng, Z.; Morris, R.; Rhee, K.Y.; Goncalves, M.D.; Cantley, L.C. Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.

Sanford-Crane, H.; Abrego, J.; Sherman, M.H. Fibroblasts as Modulators of
Local and Systemic Cancer Metabolism.

Choi, B.-H.; Coloff, J.L. The Diverse Functions of Non-Essential Amino Acids in Cancer.

Combs, J.A.; DeNicola, G.M. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival.

Villa, E.; Ali, E.S.; Sahu, U.; Ben-Sahra, I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.

Bott, A.J.; Maimouni, S.; Zong, W.-X. The Pleiotropic Effects of Glutamine Metabolism in Cancer.

Jiang, J.; Srivastava, S.; Zhang, J. Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Purohit, V.; Simeone, D.M.; Lyssiotis, C.A. Metabolic Regulation of Redox Balance in Cancer.

Petronek, M.S.; Spitz, D.R.; Buettner, G.R.; Allen, B.G. Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism.

Sharma, A.; Boise, L.H.; Shanmugam, M. Cancer Metabolism and the Evasion of
Apoptotic Cell Death.

Weinberg, F.; Ramnath, N.; Nagrath, D. Reactive Oxygen Species in the Tumor
Microenvironment: An Overview.

Cockfield, J.A.; Schafer, Z.T. Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells.

Zhou, W.; Wahl, D.R. Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance.

Guda, M.R.; Labak, C.M.; Omar, S.I.; Asuthkar, S.; Airala, S.; Tuszynski, J.; Tsung, A.J.; Velpula, K.K. GLUT1 and TUBB4 in Glioblastoma Could be Efficacious Targets.

Naffouje, R.; Grover, P.; Yu, H.; Sendilnathan, A.; Wolfe, K.; Majd, N.; Smith, E.P.; Takeuchi, K.; Senda, T.; Kofuji, S.; Sasaki, A.T. Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

Ramteke, P.; Deb, A.; Shepal, V.; Bhat, M.K.
Hyperglycemia Associated Metabolic and Molecular Alterations in Cancer Risk, Progression, Treatment, and Mortality.

Yan, L.; Raj, P.; Yao, W.; Ying, H.
Glucose Metabolism in Pancreatic Cancer.

Haley, J.A.; Ruiz, C.F.; Montal, E.D.; Wang, D.; Haley, J.D.; Girnun, G.D.
Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer.

Loponte, S.; Lovisa, S.; Deem, A.K.; Carugo, A.; Viale, A. The Many Facets of
Tumor Heterogeneity: Is Metabolism Lagging Behind?

Natarajan, S.K.; Venneti, S. Glutamine Metabolism in Brain Tumors. Cancers


Comments / other


A sugary input to leucine sensing – Elyssa Lehman, Robert T. Abraham. https://science.sciencemag.org/content/367/6474/146

How to catch a HIF-the work of Gregg Semenza’s lab on hypoxia-inducible factor 1 – Martin J. Spiering. http://www.jbc.org/content/295/3/715.full.html

Conferences:

Lactate: Unconventional roles of a nutrient along tumor landscape
Organizers: Paola Chiarugi, Pierre Sonveaux, Luigi Ippolito. Florence, Italy, May 08-10 2020. http://meetings.embo.org/event/20-lactate

Cancer Immunometabolism 2020. Rehovot, Israel, May 5-6th.
Organizers: Ayelet Erez and Eyal Gottlieb. http://www.weizmann.ac.il/conferences/CIM2020/

Cancer Metabolism and Signaling 2020. Friday, April 17, 2020, New York.
Organizers: Lydia Finley, Steven Gross, Costas Lyssiotis, Sonya Dougal, Kari Fischer. https://www.nyas.org/events/2020/cancer-metabolism-and-signaling/