MetaboList – April 2018

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Metabolism and anti-cancer immunity
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
Camila Rubio-Patiño, Jozef P. Bossowski , Gian Marco De Donatis, Laura Mondragón, Elodie Villa, Lazaro E. Aira, Johanna Chiche, Rana Mhaidly, Cynthia Lebeaupin, Sandrine Marchetti, Konstantinos Voutetakis, Aristotelis Chatziioannou, Florence A. Castelli, Patricia Lamourette, Emeline Chu-Van, François Fenaille, Tony Avril, Thierry Passeron, John B. Patterson, Els Verhoeyen, Béatrice Bailly-Maitre, Eric Chevet, Jean-Ehrland Ricci
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30120-7

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Tina Cascone,  Jodi A. McKenzie […], Patrick Hwu, Weiyi Peng
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30178-5

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Michael D. Kornberg, Pavan Bhargava, Paul M. Kim, Vasanta Putluri, Adele M. Snowman, Nagireddy Putluri, Peter A Calabresi, Solomon H. Snyder
http://science.sciencemag.org/content/360/6387/449

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy
Srikanth Battu, Sumbul Afroz, Jeevan Giddaluru, Saima Naz, Weishan Huang, Saratchandra Singh Khumukcham, Rafiq Ahmad Khan, Saleem Yousuf Bhat, Insaf Ahmed Qureshi, Bramanandam Manavathi, Aleem Ahmed Khan, Avery August, Seyed Ehtesham Hasnain, Nooruddin Khan
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005317

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
Huilin Ye, Quanbo Zhou, Shangyou Zheng, Guolin Li, Qing Lin, Lusheng Wei, Zhiqiang Fu, Bin Zhang, Yimin Liu, Zhihua Li & Rufu Chen
https://www.nature.com/articles/s41419-018-0486-0

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Glucose metabolism
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Gang Xiao, Lai N. Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M. Weinstock, Thomas G. Graeber, Markus Müschen
http://www.cell.com/cell/fulltext/S0092-8674(18)30225-3

HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang & Zhenhua Ding
https://www.nature.com/articles/s41467-018-03914-5?

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis
Francesca Ricciardiello, Giuseppina Votta, Roberta Palorini, Isabella Raccagni, Laura Brunelli, Alice Paiotta, Francesca Tinelli, Giuseppe D’Orazio, Silvia Valtorta, Luca De Gioia, Roberta Pastorelli, Rosa Maria Moresco, Barbara La Ferla & Ferdinando Chiaradonna
https://www.nature.com/articles/s41419-018-0405-4

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC
Yan Tang, Hyokjoon Kwon, Brian A Neel, Michal Kasher-Meron, Jacob Pessin, Eijiro Yamada and Jeffrey E Pessin
http://www.jbc.org/content/early/2018/04/12/jbc.RA118.002727.abstract

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Thibault Houles, Simon-Pierre Gravel, Geneviève Lavoie, Sejeong Shin, Mathilde Savall, Antoine Méant, Benoit Grondin, Louis Gaboury, Sang-Oh Yoon, Julie St-Pierre, and Philippe P. Roux
http://cancerres.aacrjournals.org/content/78/9/2191

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
Subhamoy Dasgupta, Kimal Rajapakshe, Bokai Zhu, Bryan C. Nikolai, Ping Yi, Nagireddy Putluri, Jong Min Choi, Sung Y. Jung, Cristian Coarfa, Thomas F. Westbrook, Xiang H.-F. Zhang, Charles E. Foulds, Sophia Y. Tsai, Ming-Jer Tsai & Bert W. O’Malley
https://www.nature.com/articles/s41586-018-0018-1

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang
http://www.jbc.org/content/293/17/6623.abstract.html

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
Zhifen Zhou, Min Li, Lin Zhang, Hong Zhao, Özgür Şahin, Jing Chen, Jean J. Zhao, Zhou Songyang, and Dihua Yu
http://cancerres.aacrjournals.org/content/78/9/2248

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
[pentose phosphate pathway]
Sarah A. Best, David P. De Souza, Ariena Kersbergen, Antonia N. Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H. Gray, Matthew E. Ritchie, Malcolm J. McConville, Kate D. Sutherland
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30117-7

Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer—effects of hypoxia
Ingrit Hamann, Daniel Krys, Darryl Glubrecht, Vincent Bouvet, Alison Marshall, Larissa Vos, John R. Mackey, Melinda Wuest, and Frank Wuest
http://www.fasebj.org/doi/abs/10.1096/fj.201800360R?ai=ts&ui=ly8&af=T

GLUCOSE TRANSPORTER 1 EXPRESSION AS A MARKER OF PROGNOSIS IN OESOPHAGEAL ADENOCARCINOMA
Jaine K. Blayney, Lauren Cairns, Gerald Li, Niamh McCabe, Leanne Stevenson, Christopher J. Peters, Nathan B. Reid, Veronica J. Spence, Chintapuza Chisambo, Damian McManus, Jacqueline James, Stephen McQuaid,Stephanie Craig, Kenneth Arthur, Darragh McArt, Chin-Ann J. Ong, Pierre Lao-Sirieix, Peter Hamilton, Manuel Salto-Tellez, Martin Eatock, Helen G. Coleman, Rebecca C. Fitzgerald, Richard D. Kennedy, Richard C. Turkington, and  On behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24906&path%5B%5D=78092

THE DECREASE OF GLYCOLYTIC ENZYME HEXOKINASE 1 ACCELERATES TUMOR MALIGNANCY VIA DEREGULATING ENERGY METABOLISM BUT SENSITIZES CANCER CELLS TO 2-DEOXYGLUCOSE INHIBITION
Po-Lin Tseng, Chih-Wei Chen, Keng-Hsun Hu, Hung-Chi Cheng, Yuan-Ho Lin, Wen-Hui Tsai, Tain-Junn Cheng,Wei-Hsuan Wu, Chin-Wei Yeh, Chin-Chih Lin, Hui-Ju Tsai, Hao-Chun Chang, Jiin-Haur Chuang, Yan-Shen Shan, and  Wen-Tsan Chang
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24855&path%5B%5D=77938

Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2
Priya Londhe, Peter Y. Yu, Yuichi Ijiri, Katherine J. Ladner, Joelle M. Fenger, Cheryl London, Peter J. Houghton, and Denis C. Guttridge
https://www.frontiersin.org/articles/10.3389/fonc.2018.00104/full

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation
Lu Gong, Xiao Pan, Chuan-Bian Lim, Anna de Polo, John B. Little & Zhi-Min Yuan
http://www.nature.com/articles/s41388-017-0117-8

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Amino acid metabolism
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Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
Maren Feist, Philipp Schwarzfischer, Paul Heinrich, Xueni Sun, Judith Kemper, Frederike von Bonin, Paula Perez-Rubio, Franziska Taruttis, Thorsten Rehberg, Katja Dettmer, Wolfram Gronwald, Jörg Reinders, Julia C. Engelmann, Jan Dudek, Wolfram Klapper, Lorenz Trümper, Rainer Spang, Peter J. Oefner & Dieter Kube
https://www.nature.com/articles/s41467-018-03803-x

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza and Brian J. P. Huntly
http://bloodjournal.org/content/131/15/1639.abstract?etoc

Increased formate overflow is a hallmark of oxidative cancer
Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou & Alexei Vazquez
https://www.nature.com/articles/s41467-018-03777-w

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Lipid metabolism
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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
Mark R. Lundquist, Marcus D. Goncalves, Ryan M. Loughran, Elite Possik, Tarika Vijayaraghavan, Annan Yang, Chantal Pauli, Archna Ravi, Akanksha Verma, Zhiwei Yang, Jared L. Johnson, Jenny C.Y. Wong, Yilun Ma, Katie Seo-Kyoung Hwang, David Weinkove, Nullin Divecha, John M. Asara, Olivier Elemento, Mark A. Rubin, Alec C. Kimmelman, Arnim Pause, Lewis C. Cantley, Brooke M. Emerling
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30268-5

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation
Cong-Hui Yao, Gao-Yuan Liu, Rencheng Wang, Sung Ho Moon, Richard W. Gross, Gary J. Patti
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003782

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis
Andras Ladanyi, Abir Mukherjee, Hilary A. Kenny, Alyssa Johnson, Anirban K. Mitra, Sinju Sundaresan , Kristin M. Nieman , Gloria Pascual , Salvador Aznar Benitah , Anthony Montag , S. Diane Yamada , Nada A. Abumrad & Ernst Lengyel
http://www.nature.com/articles/s41388-017-0093-z

STAT3-ACTIVATED CD36 FACILITATES FATTY ACID UPTAKE IN CHRONIC LYMPHOCYTIC LEUKEMIA CELLS
Uri Rozovski, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Alessandra Ferrajoli, Jan Burger, Phillip Thompson, Nitin Jain, William Wierda, Michael J. Keating,  and  Zeev Estrov
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25066

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang
http://www.jbc.org/content/293/17/6623.abstract.html

Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
Jiankai Liang, Li Guo, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin & Guangmei Yan
https://www.nature.com/articles/s41467-018-03913-6

TARGETING THE MEVALONATE PATHWAY IS A NOVEL THERAPEUTIC APPROACH TO INHIBIT ONCOGENIC FOXM1 TRANSCRIPTION FACTOR IN HUMAN HEPATOCELLULAR CARCINOMA
Satoshi Ogura, Yuichi Yoshida, Tomohide Kurahashi, Mayumi Egawa, Kunimaro Furuta, Shinichi Kiso, Yoshihiro Kamada, Hayato Hikita, Hidetoshi Eguchi, Hisakazu Ogita, Yuichiro Doki, Masaki Mori, Tomohide Tatsumi,  and  Tetsuo Takehara
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24781

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Nucleotides and one carbon metabolism
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Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma
Hideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii, Masahiro Tsuboi, Atsushi Ochiai, Hiroyasu Esumi, Takehiko Sasaki, Koichi Goto, and Katsuya Tsuchihara
http://cancerres.aacrjournals.org/content/78/9/2179

One-carbon metabolism biomarkers and genetic variants in relation to colorectal cancer risk by KRAS and BRAF mutation status
Robin Myte , Björn Gylling, Jenny Häggström, Jörn Schneede, Anna Löfgren-Burström, Jeroen R. Huyghe, Göran Hallmans, Klaus Meyer, Ingegerd Johansson, Per Magne Ueland, Richard Palmqvist, Bethany Van Guelpen
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196233

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Mitochondria
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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30374-7

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations
Qiuying Chen, Kathryne Kirk, Yevgeniya I. Shurubor, Dazhi Zhao, Andrea J. Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L. Calder, Valerio Carelli, Travis T. Denton, M. Flint Beal, Steven S. Gross, Giovanni Manfredi, Marilena D’Aurelio
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30180-3

Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
Grace R. Anderson, Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell & Kris C. Wood
https://www.nature.com/articles/s41467-018-04033-x

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect
Dan Li, Chaoqun Wang, Panfei Ma, Qingan Yu, Mingqi Gu, Liqian Dong, Wenjing Jiang, Shangha Pan, Changming Xie, Jihua Han, Yaliang Lan, Jing Sun, Ping Sheng, Kunpeng Liu, Yaohua Wu, Lianxin Liu, Yong Ma & Hongchi Jiang
https://www.nature.com/articles/s41419-018-0494-0

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Starvation / nutrient sensing
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Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation
Ashish Kumar, Sagnik Giri, Chandrima Shaha
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14406?campaign=woletoc

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms
[Glc deprivation inhibits autophagy]
Chinwendu Nwadike, Leon E. Williamson, Laura E. Gallagher, Jun-Lin Guan and Edmond Y. W. Chan
http://mcb.asm.org/content/38/10/e00023-18.abstract?etoc

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
[Glc deprivation induces autophagy]
Xiaoyan Zhang, Leibin Wang, Behnam Lak, Jie Li, Eija Jokitalo, Yanzhuang Wang
https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30243-0

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
Ruth Shiloh, Yuval Gilad, Yaara Ber, Miriam Eisenstein, Dina Aweida, Shani Bialik, Shenhav Cohen & Adi Kimchi
https://www.nature.com/articles/s41467-018-03907-4

Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Giulia Allavena, Francesca Cuomo, Georg Baumgartner, Tadeja Bele, Alexander Yarar Sellgren, Kyaw Soe Oo, Kaylee Johnson, Vladimir Gogvadze, Boris Zhivotovsky & Vitaliy O Kaminskyy
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1405192

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Marc J. Tol, Martijn J.C. van der Lienden, Tanit L. Gabriel, Jacob J. Hagen, Saskia Scheij, Tineke Veenendaal, Judith Klumperman, Wilma E. Donker-Koopman, Arthur J. Verhoeve, Hermen Overkleeft, Johannes M. Aerts, Carmen A. Argmann & Marco van Eijk
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1419118

Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane
Hirofumi Ukai, Yasuhiro Araki, Shintaro Kira, Yu Oikawa, Alexander I. May, Takeshi Noda
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007334

FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction
Katarzyna Nowak, Avantika Gupta, Hugo Stocker
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007347

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation
Chi Kwan Tsang, Miao Chen, Xin Cheng, Yanmei Qi, Yin Chen, Ishani Das, Xiaoxing Li, Brinda Vallat, Li-Wu Fu, Chao-Nan Qian, Hui-Yun Wang, Eileen White, Stephen K. Burley, X.F. Steven Zheng
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30232-6

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
Toby A. Dite, Christopher G. Langendorf, Ashfaqul Hoque, Sandra Galic, Richard J. Rebello, Ashley J. Ovens, Lisa M. Lindqvist, Kevin R.W. Ngoei, Naomi X. Y. Ling, Luc Furic, Bruce E. Kemp, John Walter Scott and Jonathan S. Oakhill
http://www.jbc.org/content/early/2018/04/25/jbc.RA118.003547.abstract

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IDH
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Mutant IDH1 Promotes Glioma Formation In Vivo
Beatrice Philip, Diana X. Yu, Mark R. Silvis, Clifford H. Shin, James P. Robinson, Gemma L. Robinson, Adam E. Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua A. Sonnen, Matthew W. VanBrocklin, Richard J. Gibbons, Ryan E. Looper, Howard Colman, Sheri L. Holmen
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30521-7

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
Ovidiu C. Andronesi, Isabel C. Arrillaga-Romany, K. Ina Ly, Wolfgang Bogner, Eva M. Ratai, Kara Reitz, A. John Iafrate, Jorg Dietrich, Elizabeth R. Gerstner, Andrew S. Chi, Bruce R. Rosen, Patrick Y. Wen, Daniel P. Cahill & Tracy T. Batchelor
https://www.nature.com/articles/s41467-018-03905-6

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0178-3

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Wei Qiang Ong, Hema Artee Luchman, J. Gregory Cairncross, Bo Huang, Russell O. Pieper, Joanna J. Phillips, and Sabrina M. Ronen
http://cancerres.aacrjournals.org/content/78/9/2290

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola and Harley I. Kornblum
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0177-4

Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2–β-Catenin–BRG1 Transcriptional Network-Driven CD47 Expression
Pruthvi Gowda, Shruti Patrick, Ankita Singh, Touseef Sheikh and Ellora Sen
http://mcb.asm.org/content/38/9/e00001-18.abstract?etoc

Wild-type and mutated IDH1/2 enzymes and therapy responses
Remco J. Molenaar, Jaroslaw P. Maciejewski, Johanna W. Wilmink & Cornelis J. F. van Noorden
https://www.nature.com/articles/s41388-017-0077-z

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Hypoxia
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LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response
Ji Hee Ha, Rangasudhagar Radhakrishnan, Muralidharan Jayaraman, Mingda Yan, Jeremy D. Ward, Kar-Ming Fung, Katherine Moxley, Anil K. Sood, Ciro Isidoro, Priyabrata Mukherjee, Yong Sang Song and Danny N. Dhanasekaran
http://cancerres.aacrjournals.org/content/78/8/1923

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Yan Chen, Bo Zhang, Lei Bao, Lai Jin, Mingming Yang, Yan Peng, Ashwani Kumar, Jennifer E. Wang, Chenliang Wang, Xuan Zou, Chao Xing, Yingfei Wang, and Weibo Luo
https://www.jci.org/articles/view/95089

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Miscellaneous
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Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
Jiska van der Reest, Sergio Lilla, Liang Zheng, Sara Zanivan & Eyal Gottlieb
http://www.nature.com/articles/s41467-018-04003-3

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Jennifer Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Björn Kruspig, Ann Hedley, Gabriela Kalna, Sergio Lilla, Lisa Neilson, Martina Brucoli, Katarina Gyuraszova, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara R. Zanivan, and Daniel J. Murphy
http://cancerdiscovery.aacrjournals.org/content/8/5/632

Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
Chen Dai, Jennifer Arceo, James Arnold, Arun Sreekumar, Norman J. Dovichi, Jun Li and Laurie E. Littlepage
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0175-6

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
Wei Yan , Xiwei Wu , Weiying Zhou , Miranda Y. Fong , Minghui Cao ,Juan Liu , Xiaojing Liu ,Chih-Hong Chen , Oluwole Fadare, Donald P. Pizzo ,Jiawen Wu , Liang Liu ,Xuxiang Liu, Andrew R. Chin & &, Xiubao Ren ,Yuan Chen , Jason W. Locasale & Shizhen Emily Wang
http://www.nature.com/articles/s41556-018-0083-6

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments
Christopher Ecker, Lili Guo, Stefana Voicu, Luis Gil-de-Gómez, Andrew Medvec, Luis Cortina, Jackie Pajda, Melanie Andolina, Maria Torres-Castillo, Jennifer L. Donato, Sarya Mansour, Evan R. Zynda, Pei-Yi Lin, Angel Varela-Rohena, Ian A. Blair, James L. Riley
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30445-5

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
Jianfeng Huang, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Elias A. Castilla, Timo D. Müller, Matthias H. Tschöp, Jorge Moscat, Maria T. Diaz-Meco
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30069-2

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues
Ayana Sasaki, Takahiro Nagatake, Riku Egami, Guoqiang Gu, Ichigaku Takigawa, Wataru Ikeda, Tomoya Nakatani, Jun Kunisawa, Yasuyuki Fujita
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7

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Reviews
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Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease
Raquel Buj and Katherine M. Aird
https://www.frontiersin.org/articles/10.3389/fendo.2018.00177/full

New links between lipid accumulation and cancer progression
Joseph T. Nickels Jr.
http://www.jbc.org/content/293/17/6635.abstract.html

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
Russell A. DeBose-Boyd, Jin Ye
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30005-7

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
Simon-Pierre Gravel
https://www.frontiersin.org/articles/10.3389/fonc.2018.00075/full

Metabolic Reprogramming During Multidrug Resistance in Leukemias
Raphael Vidal, Julia Quarti, Franklin Rumjanek, and Vivian Rumjanek
https://www.frontiersin.org/articles/10.3389/fonc.2018.00090/full

Metabolic Reprogramming in Thyroid Carcinoma
Raquel Coelho, Rodrigo Fortunato, and Denise Carvalho
https://www.frontiersin.org/articles/10.3389/fonc.2018.00082/full

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo Salustiano, Luciana Gentile, Luciana Conde Rodrigues Maia, Alessandra Filardy, Tatiany Franklim, Kelli da Costa, Celio Freire-de-Lima, and Leonardo Freire-de-Lima
https://www.frontiersin.org/articles/10.3389/fonc.2018.00081/full

Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy
Sun-Hee Kim, Jason Roszik, Elizabeth Grimm, and Suhendan Ekmekcioglu
https://www.frontiersin.org/articles/10.3389/fonc.2018.00067/full

The Proline Cycle As a Potential Cancer Therapy Target.
Tanner JJ, Fendt SM, Becker DF.
https://pubs.acs.org/doi/10.1021/acs.biochem.8b00215

Metabolic features of cancer stem cells: the emerging role of lipid metabolism
Rita Mancini, Alessia Noto, Maria Elena Pisanu, Claudia De Vitis, Marcello Maugeri-Saccà & Gennaro Ciliberto
https://www.nature.com/articles/s41388-018-0141-3

Metabolomics and Isotope Tracing
Cholsoon Jang, Li Chen, Joshua D. Rabinowitz
https://www.cell.com/cell/fulltext/S0092-8674(18)30387-8

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Comments
———————-

Eating the Beast: Dietary Protein and Anticancer Immunity
Douglas R. Green
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30184-0

To Claim Growth Turf, mTOR Says SOD Off
Hyewon Kong, Navdeep S. Chandel
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30311-3

Immune Evasion in Tumor’s Own Sweet Way
Haidong Tang, Yang-Xin Fu
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30191-8

The Science and Translation of Lactate Shuttle Theory
George A. Brooks
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30186-4

Metabolic strugGLS after FLT3 inhibition in AML
Samuel J. Taylor and Ulrich Steidl
http://www.bloodjournal.org/content/131/15/1631

Breast cancer: Obesity: tipping the scales of resistance
Conor A. Bradley
http://www.nature.com/articles/nrc.2018.31

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition
Sara Lovisa, Raghu Kalluri
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30049-2

MYC sets a tumour-stroma metabolic loop
Hilary A. Coller
http://www.nature.com/articles/s41556-018-0096-1

When ER stress is bad for cancer
http://stke.sciencemag.org/content/11/528/eaau0066

MetaboList – March 2018

————————————————————-
Glycolysis and glycolytic enzymes
————————————————————-

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth
Mami Morita, Taku Sato, Miyuki Nomura, Yoshimi Sakamoto, Yui Inoue, Ryota Tanaka, Shigemi Ito, Koreyuki Kurosawa, Kazunori Yamaguchi, Yuki Sugiura, Hiroshi Takizaki, Yoji Yamashita, Ryuichi Katakura, Ikuro Sato, Masaaki Kawai, Yoshinori Okada, Hitomi Watanabe, Gen Kondoh, Shoko Matsumoto, Ayako Kishimoto, Miki Obata, Masaki Matsumoto, Tatsuro Fukuhara, Hozumi Motohashi, Makoto Suematsu, Masaaki Komatsu, Keiichi I. Nakayama, Toshio Watanabe, Tomoyoshi Soga, Hiroshi Shima, Makoto Maemondo, Nobuhiro Tanuma
http://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30057-6

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism
Ramachandran Rashmi, Xiaojing Huang, John M. Floberg, Adnan E. Elhammali, Michael L. McCormick, Gary J. Patti, Douglas R. Spitz and Julie K. Schwarz
http://cancerres.aacrjournals.org/content/78/6/1392

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
Natthakan Thongon, Chiara Zucal, Vito Giuseppe D’Agostino, Toma Tebaldi, Silvia Ravera, Federica Zamporlini, Francesco Piacente, Ruxanda Moschoi, Nadia Raffaelli, Alessandro Quattrone, Alessio Nencioni, Jean-Francois Peyron and Alessandro Provenzani
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0174-7

Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4
Wenzhi Jia, Xiaoping Zhao, Li Zhao, Hui Yan, Jiajin Li, Hao Yang, Gang Huang & Jianjun Liu
https://www.nature.com/articles/s41388-017-0072-4

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein
Tsu-Yao Cheng, Yi-Chieh Yang, Hsiu-Po Wang, Yu-Wen Tien, Chia-Tung ShunHsin-Yi Huang,Michael Hsiao & Kuo-Tai Hua
https://www.nature.com/articles/s41388-017-0086-y

Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors
Raeeka Khamari, Anne Trinh, Pierre Elliott Gabert, Paola Corazao-Rozas, Samuel Riveros-Cruz, Stephane Balayssac, Myriam Malet-Martino, Salim Dekiouk, Marie Joncquel Chevalier Curt, Patrice Maboudou, Guillaume Garçon, Laura Ravasi, Pierre Guerreschi, Laurent Mortier, Bruno Quesnel, Philippe Marchetti & Jerome Kluza
https://www.nature.com/articles/s41419-018-0340-4

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye
http://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30010-2

GLYCOGEN DEBRANCHING ENZYME (AGL) IS A NOVEL REGULATOR OF NON-SMALL CELL LUNG CANCER GROWTH
Craig S. Richmond, Darby Oldenburg, Garrett Dancik, David R. Meier, Benjamin Weinhaus, Dan Theodorescu,  and  Sunny Guin
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24676&path%5B%5D=77411

Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4
Li Wang, Jing-jing Li, Li-yu Guo, Peipei Li, Zhiqiang Zhao,  Haisheng Zhou & Li-jun Di
https://www.nature.com/articles/s41389-018-0036-8

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Annemarie Schwab, Aarif Siddiqui, Maria Eleni Vazakidou, Francesca Napoli, Martin Böttcher, Bianca Menchicchi, Umar Raza, Özge Saatci, Angela M. Krebs, Fulvia Ferrazzi, Ida Rapa, Katja Dettmer-Wilde, Maximilian J. Waldner, Arif B. Ekici, Suhail Ahmed Kabeer Rasheed, Dimitrios Mougiakakos, Peter J. Oefner, Ozgur Sahin, Marco Volante, Florian R. Greten, Thomas Brabletz and Paolo Ceppi
http://cancerres.aacrjournals.org/content/78/7/1604

Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer
Nicoletta Caronni, Francesca Simoncello, Francesca Stafetta, Corrado Guarnaccia, Juan Sebastian Ruiz-Moreno, Bastian Opitz, Thierry Galli, Veronique Proux-Gillardeaux and Federica Benvenuti
http://cancerres.aacrjournals.org/content/78/7/1685

———————–
Amino acids
———————–

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism
Xia Gao, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, Jason W. Locasale
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30346-2

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo
Hien Anh Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic, Michael Caffrey, Amanda M. Schalk, Li Liu, Damiano Rondelli, Annie Oh, Dolores L. Mahmud, Maarten C. Bosland, Andre Kajdacsy-Balla, Sofie Peirs, Tim Lammens, Veerle Mondelaers, Barbara De Moerloose, Steven Goossens, Michael J. Schlicht, Kasim K. Kabirov, Alexander V. Lyubimov, Bradley J. Merrill, Yogen Saunthararajah, Pieter Van Vlierberghe and Arnon Lavie
http://cancerres.aacrjournals.org/content/78/6/1549

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent
Tingting Wang, Lingling Liu, Xuyong Chen, Yuqing Shen, Gaojian Lian, Nilay Shah, Andrew M Davidoff, Jun Yang & Ruoning Wang
https://www.nature.com/articles/s41419-018-0295-5

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
Marta Mauro-Lizcano & Abelardo López-Rivas
https://www.nature.com/articles/s41419-018-0263-0

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30294-8

—————————–
Lipid metabolism
—————————–

Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang
http://www.jbc.org/content/early/2018/03/07/jbc.RA117.000100.abstract

Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
Yongtao Wang, Yixin Chen, Lihuan Guan, Huizheng Zhang, Yaoyao Huang, Caroline H. Johnson, Zeming Wu, Frank J. Gonzalez, Aiming Yu,Peng Huang, Ying Wang, Shouhui Yang, Pan Chen, Xiaomei Fan, Min Huang & Huichang Bi
https://www.nature.com/articles/s41418-017-0013-3

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Yang-An Wen, Xiaopeng Xiong, Yekaterina Y. Zaytseva, Dana L. Napier, Emma Vallee, Austin T. Li, Chi Wang, Heidi L. Weiss, B. Mark Evers & Tianyan Gao
https://www.nature.com/articles/s41419-018-0330-6

———————–
Nucleotides
———————–

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Marcus J. G. W. Ladds , Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson […] Sonia Laín
https://www.nature.com/articles/s41467-018-03441-3

————————-
Mitochondria
————————-

Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells
Ryo Yonashiro, Kayoko Eguchi, Masaki Wake, Norihiko Takeda and Koh Nakayama
http://cancerres.aacrjournals.org/content/78/7/1592

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
Meng-Xi Liu, Lei Jin, Si-Jia Sun, Peng Liu, Xu Feng Zhou-Li Cheng, Wei-Ren Liu, Kun-Liang Guan, Ying-Hong Shi, Hai-Xin Yuan & Yue Xiong
https://www.nature.com/articles/s41388-017-0070-6

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant & Olivier Feron
https://www.nature.com/articles/s41467-018-03525-0

Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells
Shuyan Wang, Xiaohai Shi, Shuang Wei, Ding Ma, Olutobi Ajala, Sheng-Qing Lv, Mingyao Ying, Yu Alex Zhang, Steven Michael Claypool, Paul Watkins and Shuli Xia
http://www.jbc.org/content/early/2018/03/05/jbc.RA117.001323.abstract

—————————
AMPK family
—————————

Colorectal tumors require NUAK1 for protection from oxidative stress
Jennifer L. F. Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Bjorn Kruspig, Ann Hedley, Gabriela Kalna, Sergio Lilla, Lisa Neilson, Martina Brucoli, Katarina Gyuraszova, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara Zanivan and Daniel J. Murphy
http://cancerdiscovery.aacrjournals.org/content/early/2018/03/02/2159-8290.CD-17-0533

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation
Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A. Balaji, Prashant Kumar, Sravanth K. Hindupur and Annapoorni Rangarajan
http://cancerres.aacrjournals.org/content/78/6/1497

———————-
mTOR
———————-

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu& David M. Sabatini
https://www.nature.com/articles/nature26158

Architecture of the human mTORC2 core complex
Edward Stuttfeld, Christopher HS Aylett,  Stefan Imseng,  Daniel Boehringer, Alain Scaiola,  Evelyn Sauer, Michael N Hall, Timm Maier, Nenad Ban
https://elifesciences.org/articles/33101

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth
Jianjun Zhang , Jianping Guo, Xing Qin, Bin Wang, Linli Zhang, Yingnan Wang, Wenjian Gan, Pier Paolo Pandofi, Wantao Chen, Wenyi Wei
http://stke.sciencemag.org/content/11/523/eaao1052

Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival
Thomas A. Werfel, Shan Wang, Meredith A. Jackson, Taylor E. Kavanaugh, Meghan Morrison Joly, Linus H. Lee, Donna J. Hicks, Violeta Sanchez, Paula Gonzalez Ericsson, Kameron V. Kilchrist, Somtochukwu C. Dimobi, Samantha M. Sarett, Dana M. Brantley-Sieders, Rebecca S. Cook and Craig L. Duvall
http://cancerres.aacrjournals.org/content/78/7/1845

———————————————–
Starvation, angiogenesis
———————————————–

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, Michael R. MacArthur, Abhirup Das, J. Humberto Treviño-Villarreal, Christopher Hine, Issam Ben-Sahra, Nelson H. Knudsen, Lear E. Brace, Justin Reynolds, Pedro Mejia, Ming Tao, Gaurav Sharma, Rui Wang, Jean-Marc Corpataux, Jacques-Antoine Haefliger, Kyo Han Ahn, Chih-Hao Lee, Brendan D. Manning, David A. Sinclair, Christopher S. Chen, C. Keith Ozaki, James R. Mitchell
http://www.cell.com/cell/fulltext/S0092-8674(18)30281-2

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
Annan Yang, Grit Herter-Sprie, Haikuo Zhang, Elaine Y. Lin, Douglas Biancur, Xiaoxu Wang, Jiehui Deng, Josephine Hai, Shenghong Yang, Kwok-Kin Wong and Alec C. Kimmelman
http://cancerdiscovery.aacrjournals.org/content/8/3/276

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter & Albert R. La Spada
https://www.nature.com/articles/s41467-018-03340-7

Glucose Starvation Increases V-ATPase Assembly and Activity in Mammalian Cells through AMP Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling
Christina M. McGuire and Michael Forgac
http://www.jbc.org/content/early/2018/03/14/jbc.RA117.001327.abstract

PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Higinio Dopeso, Hui-Ke Jiao, Angel M. Cuesta, Anne-Theres Henze, Liane Jurida, Michael Kracht, Amparo Acker-Palmer, Boyan K.Garvalov and Till Acker
http://cancerres.aacrjournals.org/content/78/7/1805

————————–
Miscellaneous
————————–

Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases
Arnaud Blomme, Gaetan Van Simaeys, Gilles Doumont, Brunella Costanza, Justine Bellier, Yukihiro Otaka, Félicie Sherer, Pierre Lovinfosse, Sébastien Boutry, Ana Perez Palacios, Edwin De Pauw, Touko Hirano, Takehiko Yokobori, Roland Hustinx, Akeila Bellahcène, Philippe Delvenne, Olivier Detry, Serge Goldman, Masahiko Nishiyama, Vincent Castronovo & Andrei Turtoi
https://www.nature.com/articles/s41388-017-0018-x?

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
Lifeng Li, Liping Wang, Jieyao Li, Zhirui Fan, Li Yang, Zhen Zhang, Chaoqi Zhang, Dongli Yue, Guohui Qin, Tengfei Zhang, Feng Li, Xinfeng Chen, Yu Ping, Dan Wang, Qun Gao, Qianyi He, Lan Huang, Hong Li, Jianmin Huang, Xuan Zhao, Wenhua Xue, Zhi Sun, Jingli Lu, Jane J. Yu, Jie Zhao, Bin Zhang and Yi Zhang
http://cancerres.aacrjournals.org/content/78/7/1779

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
Ching-Wen Chang, Yu-Syuan Chen, Yeou-Guang Tsay, Chia-Li Han, Yu-Ju Chen, Cheng-Chieh Yang, Kai-Feng Hung, Chao-Hsiung Lin, Tsung-Yen Huang, Shou-Yen Kao, Te-Chang Lee & Jeng-Fan Lo
https://www.nature.com/articles/s41419-017-0250-x

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova-Kostova, Richard C. Hartley, Michael P. Murphy& Luke A. O’Neill
https://www.nature.com/articles/nature25986

Unravelling the metabolic progression of breast cancer cells to bone metastasis by coupling Raman spectroscopy and a novel use of MCR-ALS algorithm
Monica Marro, Claudia Nieva, Anna De Juan, and Angels Sierra
https://pubs.acs.org/doi/10.1021/acs.analchem.7b04527

——————–
Reviews
——————–

Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response
Sophia Y. Lunt, Sarah-Maria Fendt
https://www.sciencedirect.com/science/article/pii/S245231001730183X

Metabolic exhaustion in infection, cancer and autoimmunity
E. F. McKinney & K. G. C. Smith
https://www.nature.com/articles/s41590-018-0045-y

The Role of Mitochondrial H+-ATP Synthase in Cancer
Pau Esparza-Moltó, and Jose Cuezva
https://www.frontiersin.org/articles/10.3389/fonc.2018.00053/full

The carnitine system and cancer metabolic plasticity
Melone Mariarosa Anna Beatrice, Valentino Anna, Margarucci Sabrina, Galderisi Umberto, Giordano Antonio
https://www.nature.com/articles/s41419-018-0313-7

Targeting angiogenic metabolism in disease
Xuri Li, Peter Carmeliet
http://science.sciencemag.org/content/359/6382/1335

Crosstalks between translation and metabolism in cancer
Stefano Biffo, Nicola Manfrini, Sara Ricciardi
https://www.sciencedirect.com/science/article/pii/S0959437X17300849

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer
Lisa M Lindqvist, Kristofferson Tandoc, Ivan Topisirovic, Luc Furic
https://www.sciencedirect.com/science/article/pii/S0959437X17301508

Metabolic Kinases Moonlighting as Protein Kinases
Zhimin Lu, Tony Hunter
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(18)30020-3

Extracellular matrix internalization links nutrient signalling to invasive migration
Elena Rainero
https://onlinelibrary.wiley.com/doi/abs/10.1111/iep.12265

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Comments
————————–

Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues
Annamarie E. Allen, Jason W. Locasale
http://www.cell.com.sire.ub.edu/cancer-cell/fulltext/S1535-6108(18)30061-8

Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
Estela Noguera-Ortega and Ravi K. Amaravadi
http://cancerdiscovery.aacrjournals.org/content/8/3/266

Asparagine Bioavailability Drives Breast Cancer Metastasis
http://cancerdiscovery.aacrjournals.org/content/8/4/381.2

MetaboList – February 2018

 
—————————————–
Amino acids / nucleotides
—————————————–
 
Asparagine bioavailability governs metastasis in a model of breast cancer
Simon R. V. Knott, Elvin Wagenblast, Showkhin Khan, Sun Y. Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, Clive S. D’Santos, Lisa A. Carey, John E. Wilkinson, J. Chuck Harrell, Charles M. Perou, Hani Goodarzi, George Poulogiannis & Gregory J. Hannon
 
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Michael L Schulte, Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T Smith, Jumpei Kondo, Robert J Coffey, Marc O Johnson, Jeffrey C Rathmell, Joe T Sharick, Melissa C Skala, Jarrod A Smith, Jordan Berlin, M Kay Washington, Michael L Nickels & H Charles Manning
 
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
Denise R. Minton, Minwoo Nam, Daniel J. McLaughlin, Jong Shin, Erol C. Bayraktar, Samantha W. Alvarez, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, David M. Sabatini, Kıvanç Birsoy, Richard Possemato
 
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu, Ji-Lin Wang, Tian-Hui Zou, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen & Jing-Yuan Fang
 
Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition
Seungyeon Yang, Sunsook Hwang, Minjoong Kim, Sung Bin Seo, Jeong-Hwa Lee & Seung Min Jeong
 
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Karina N. Gonzalez Herrera, Elma Zaganjor, Yoshinori Ishikawa, Jessica B. Spinelli, Haejin Yoon, Jia-Ren Lin, F. Kyle Satterstrom, Alison Ringel, Stacy Mulei, Amanda Souza, Joshua M. Gorham, Craig C. Benson, Jonathan G. Seidman, Peter K. Sorger, Clary B. Clish, Marcia C. Haigis
 
———————————–
Glycolysis and PPP
———————————–
 
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
Dongxin Zhao, Mehmet G. Badur, Jens Luebeck, Jose H. Magaña, Amanda Birmingham, Roman Sasik, Christopher S. Ahn, Trey Ideker, Christian M. Metallo, Prashant Mali
 
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
Xiaoyu Ma, Xiaoyu Ma, Lin Wang, Lin Wang, De Huang, De Huang, Yunyan Li, Yunyan Li, Dongdong Yang, Dongdong Yang, Tingting Li, Tingting Li, Fudong Li, Fudong Li, Linchong Sun, Linchong Sun, Haoran Wei, Haoran Wei, Kun He, Kun He, Fazhi Yu, Fazhi Yu, Debiao Zhao, Debiao Zhao, Lan Hu, Lan Hu, Songge Xing, Songge Xing, Zhaoji Liu, Zhaoji Liu, Kui Li, Kui Li, Jing Guo, Jing Guo, Zhenye Yang, Zhenye Yang, Xin Pan, Xin Pan, Ailing Li, Ailing Li, Yunyu Shi, Yunyu Shi, Junfeng Wang, Junfeng Wang, Ping Gao, Ping Gao, Huafeng Zhang
 
A Mathematical Model for Enzyme Clustering in Glucose Metabolism
Miji Jeon, Hye-Won Kang & Songon An
 
Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells
Touseef Sheikh, Piyushi Gupta, Pruthvi Gowda, Shruti Patrick and Ellora Sen
 
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan & Hai-Xin Yuan
 
The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose
Xiang Li, Shichang Deng, Mingliang Liu, Yan Jin, Shuai Zhu, Shijiang Deng, Jingyuan Chen, Chi He, Qi Qin, Chunyou Wang & Gang Zhao
 
SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization
Yuanyuan Weng, Xueyu Fan, Yongfeng Bai, Siwei Wang, Hui Huang, Huimin Yang, Jin Zhu & Feng Zhang
 
 
——————-
Lipids
——————-
 
IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Hong Xie, Chih-Hang Anthony Tang, Jun H. Song, Anthony Mancuso, Juan R. Del Valle, Jin Cao, Yan Xiang,Chi V. Dang, Roy Lan, Danielle J. Sanchez, Brian Keith, Chih-Chi Andrew Hu, and M. Celeste Simon
 
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Ming Chen, Jiangwen Zhang, Katia Sampieri, John G. Clohessy, Lourdes Mendez, Enrique Gonzalez-Billalabeitia, Xue-Song Liu, Yu-Ru Lee, Jacqueline Fung, Jesse M. Katon, Archita Venugopal Menon, Kaitlyn A. Webster, Christopher Ng, Maria Dilia Palumbieri, Moussa S. Diolombi, Susanne B. Breitkopf, Julie Teruya-Feldstein, Sabina Signoretti, Roderick T. Bronson, John M. Asara, Mireia Castillo-Martin, Carlos Cordon-Cardo & Pier Paolo Pandolfi
 
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D’Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero, Nicolas Delaleu, Andrea Rinaldi, Francesco Bertoni, Johann de Bono, Arkaitz Carracedo & Andrea Alimonti
 
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
Silvia Escudero, Elma Zaganjor, Susan Lee, Christopher P. Mill, Ann M. Morgan, Emily B. Crawford, Jiahao Chen, Thomas E. Wales, Rida Mourtada, James Luccarelli, Gregory H. Bird, Ulrich Steidl, John R. Engen, Marcia C. Haigis, Joseph T. Opferman, Loren D. Walensky
 
Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
Bandish Kapadia, Nahid M. Nanaji, Kavita Bhalla, Binny Bhandary, Rena Lapidus, Afshin Beheshti, Andrew M. Evens & Ronald B. Gartenhaus
 
Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer
W Han, S Gao, D Barrett, M Ahmed, D Han, J A Macoska, H H He and C Cai
 
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation
V L Sodi, Z A Bacigalupa, C M Ferrer, J V Lee, W A Gocal, D Mukhopadhyay, K E Wellen, M Ivan & M J Reginato
 
LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu and Shuzhong Yao
 
A Metabolic Basis for Endothelial-to-Mesenchymal Transition
Jianhua Xiong, Hiroyuki Kawagishi, Ye Yan, Jie Liu, Quinn S. Wells, Lia R. Edmunds, Maria M. Fergusson, Zu-Xi Yu, Ilsa I. Rovira, Evan L. Brittain, Michael J. Wolfgang, Michael J. Jurczak, Joshua P. Fessel, Toren Finkel
 
Metabolic Profile of Oral Squamous Carcinoma Cell Lines Relies on a Higher Demand of Lipid Metabolism in Metastatic Cells
Ana Carolina Sant´Anna-Silva, Gilson Costa dos Santos Junior, Samir Campos, Andre Gomes, Juan Pérez-Valencia, and Franklin Rumjanek
 
Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Kiran Kurmi, Sadae Hitosugi, Elizabeth K. Wiese, Felix Boakye-Agyeman, Wilson I. Gonsalves, Zhenkun Lou, Larry M. Karnitz, Matthew P. Goetz, Taro Hitosugi
 
 
————————
Mitochondria
————————
 
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
Edoardo Gaude, Christina Schmidt, Payam A. Gammage, Aurelien Dugourd, Thomas Blacker, Sew Peak Chew, Julio Saez-Rodriguez, John S. O’Neill, Gyorgy Szabadkai, Michal Minczuk, Christian Frezza
 
Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53
Giuseppe Arena, Madi Yann Cissé, Samuel Pyrdziak, Laurent Chatre, Romain Riscal, Maryse Fuentes, Jamie Jon Arnold, Markus Kastner, Laurie Gayte, Christelle Bertrand-Gaday, Kevin Nay, Claire Angebault-Prouteau, Kerren Murray, Beatrice Chabi, Christelle Koechlin-Ramonatxo, Béatrice Orsetti, Charles Vincent, François Casas, Jean-Christophe Marine, Sandrine Etienne-Manneville, Florence Bernex, Anne Lombès, Craig Eugene Cameron, Hervé Dubouchaud, Miria Ricchetti, Laetitia Karine Linares, Laurent Le Cam
 
Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer
Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun, Guowang Xu
 
Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α
Subhasree Basu, Keerthana Gnanapradeepan, Thibaut Barnoud, Che-Pei Kung, Michele Tavecchio, Jeremy Scott, Andrea Watters, Qing Chen, Andrew V. Kossenkov and Maureen E. Murphy
 
 
——————————–
Hypoxia and HIFs
——————————–
 
Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Felipe Paredes, Kely Sheldon, Bernard Lassègue, Holly C. Williams, Elizabeth A. Faidley, Gloria A. Benavides, Gloria Torres, Fernanda Sanhueza-Olivares, Samantha M. Yeligar, Kathy K. Griendling, Victor Darley-Usmar, and Alejandra San Martin
 
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu & Q Liu
 
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong & Yi Fan
 
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
D A Almiron Bonnin, M C Havrda, M C Lee, H Liu, Z Zhang, L N Nguyen, L X Harrington, S Hassanpour, C Cheng & M A Israel
 
The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling
Robert B. Jones, Kaitlyn A. Dorsett, Anita B Hjelmeland and Susan L. Bellis
 
FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes
Jengmin Kang, Seung-Hyun Shin, Haejin Yoon, June Huh, Hyun-Woo Shin, Yang-Sook Chun and Jong-Wan Park
 
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect
Shaoxun Xiang, Hao Gu, Lei Jin, Rick F. Thorne, Xu Dong Zhang, and Mian Wu
 
 
—————
mTOR
—————
 
Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver
Inna A. Nikonorova, Emily T. Mirek, Christina C. Signore, Michael P. Goudie, Ronald C. Wek and Tracy G. Anthony
 
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk & Eddine Saiah
 
The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
Xiaoduo Xie, Hongli Hu, […] Daming Gao
 
————————–
AMPK family
————————–
 
Phosphorylation of Cdc25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell cycle G2/M phase transition
Yuqing Shen, John William Sherman, Xuyong Chen and Ruoning Wang
 
Calcium signalling links MYC to NUAK1
T Monteverde, J Tait-Mulder, A Hedley, J R Knight, O J Sansom & D J Murphy
 
AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress
Alain Kfoury, Marzia Armaro, Caterina Collodet, Jessica Sordet‐Dessimoz, Maria Pilar Giner, Stefan Christen, Sofia Moco, Marion Leleu, Laurence de Leval, Ute Koch, Andreas Trumpp, Kei Sakamoto, Friedrich Beermann and Freddy Radtke
 
Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency
Jiaqi Gong, Haifeng Gu, Lin Zhao, Liang Wang, Pinglei Liu, Fuping Wang, Haoyu Xu & Tongbiao Zhao
 
Kinase Activity Determination of Specific AMPK Complexes/Heterotrimers in the Skeletal Muscle
Jesper B. Birk, Jørgen F. P. Wojtaszewski
 
 
——————————–
Starvation, drugs
——————————–
 
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
[amino acid deprivation]
Jun Zhou, Ji Wan, Xin Erica Shu, Yuanhui Mao, Xiao-Min Liu, Xin Yuan, Xingqian Zhang, Martin E. Hess, Jens C. Brüning, Shu-Bing Qian
 
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism
E Cuyàs, S Fernández-Arroyo, S Verdura, R Á-F García, J Stursa, L Werner, E Blanco-González, M Montes-Bayón, J Joven, B Viollet, J Neuzil & J A Menendez
 
Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins
Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Peter J. Mullen, Wail Ba-Alawi, Benjamin Haibe-Kains and Linda Z. Penn
 
 
————————–
Miscellaneous
————————–
 
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth
D Ma, X Chen, P-Y Zhang, H Zhang, L-J Wei, S Hu, J-Z Tang, M-T Zhou, C Xie, R Ou, Y Xu & K-F Tang
 
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis
Xinshou Ouyang, Sheng-Na Han, Ji-Yuan Zhang, Balazs Tamas Nemeth, Pal Pacher, Dechun Feng, Ramon Bataller, Joaquin Cabezas, Peter Stärkel, Joan Caballeria, Rebecca LePine Pongratz, Shi-Ying Cai, Bernd Schnabl, Rafaz Hoque, Yonglin Chen, Wei-hong Yang, Irma Garcia Martinez, Fu-Sheng Wang, Bin Gao, Natalie Julia Torok, Richard Glenn Kibbey, Wajahat Zafar Mehal
 
DIMETHYL FUMARATE IS HIGHLY CYTOTOXIC IN KRAS MUTATED CANCER CELLS BUT SPARES NON-TUMORIGENIC CELLS
Nathaniel Edward Bennett Saidu, Marie Bretagne, Audrey Lupo Mansuet, Pierre-Alexandre Just, Karen Leroy,Olivier Cerles, Sandrine Chouzenoux, Carole Nicco, Diane Damotte, Marco Alifano, Bruno Borghese, François Goldwasser, Frédéric Batteux,  and  Jérôme Alexandre
 
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli & Giuseppina Caretti
 
 
———————
Reviews
———————
 
Advances in Hypoxia-Inducible Factor Biology
Hani Choudhry, Adrian L. Harris
 
Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
Adam J. Wolpaw, Chi V. Dang
 
From the unfolded protein response to metabolic diseases – lipids under the spotlight
Nurulain Ho, Chengchao Xu and Guillaume Thibault
 
Ketogenic diet in cancer therapy
Daniela D. Weber, Sepideh Aminazdeh-Gohari, Barbara Kofler
 
Endothelial Cell Metabolism in Health and Disease
Katerina Rohlenova, Koen Veys, Ines Miranda-Santos, Katrien De Bock, Peter Carmeliet
 
FOXO Family in regulating Cancer and Metabolism
Ma J1, Matkar S2, He X3, Hua X4.
 
B-Cell Metabolic Remodeling and Cancer
Davide G. Franchina, Melanie Grusdat, Dirk Brenner
 
Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates
Dan Ye, Kun-Liang Guan, Yue Xiong
 
Metabolism in pluripotency: Both driver and passenger?
Perrine Dahan, Vivian Lu, Robert M.T. Nguyen, Stephanie A.L. Kennedy and Michael A. Teitell
 
Aberrant lipid metabolism in cancer cells – the role of oncolipid‐activated signaling
Upasana Ray, Sib Sankar Roy
 
DNA Damage, Repair, and Cancer Metabolism
Marc-Olivier Turgeon, Nicholas J. S. Perry and George Poulogiannis
 
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Marco B. Schaaf, Abhishek D. Garg & Patrizia Agostinis
 
Metabolism and TAM functions—it takes two to tango
Massimiliano Mazzone, Alessio Menga and Alessandra Castegna
 
Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy
Chiara Porta, Antonio Sica and Elena Riboldi
 
Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
Gopinath Prakasam, Mohammad Iqbal, Rameshwar Bamezai, and Sybille Mazurek
 
——————————-
Comments, other
——————————-
 
The Sympathetic Nervous System Drives Tumor Angiogenesis
Hubert Hondermarck, Phillip Jobling
 
m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress
Emily Nicole Powers, Gloria Ann Brar
 
Genetics of lipid metabolism in prostate cancer
Ninu Poulose, Francesca Amoroso, Rebecca E. Steele, Reema Singh, Chee Wee Ong & Ian G. Mills
 
Glutamine metabolism, the Achilles heel for medulloblastoma tumor
Maria Victoria Niklison-Chirou
 
GCN2 controls the cellular checkpoint: potential target for regulating inflammation
Xiaojing Xia, Liancheng Lei, Wanhai Qin, Lei Wang, Gaiping Zhang & Jianhe Hu
 
The interplay between mutant p53 and the mevalonate pathway
Alejandro Parrales, Elizabeth Thoenen & Tomoo Iwakuma
 
 
Free Webinar: Oxygen Sensing in Cancer and Metabolism
Speakers: Celeste Simon, Cullen Taniguchi and Othon Iliopoulos.

MetaboList – January 2018

———————–
Amino acids
———————–

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
Dana M. Gwinn, Alex G. Lee, Marcela Briones-Martin-del-Campo, Crystal S. Conn, David R. Simpson, Anna I. Scott, Anthony Le, Tina M. Cowan, Davide Ruggero, E. Alejandro Sweet-Cordero
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30555-X

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
Natalya N. Pavlova, Sheng Hui, Jonathan M. Ghergurovich, Jing Fan, Andrew M. Intlekofer, Richard M. White, Joshua D. Rabinowitz, Craig B. Thompson, Ji Zhang
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30716-7

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero & Jim C. Norman
https://www.nature.com/articles/s41467-017-02101-2

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
Xin Yang, Zhe Wang, Xin Li, Boya Liu, Minghui Liu, Lu Liu, Shuaiyi Chen, Mengmeng Ren, Yankun Wang, Miao Yu, Bo Wang, Junhua Zou, Wei-Guo Zhu, Yuxin Yin, Wei Gu and Jianyuan Luo
http://cancerres.aacrjournals.org/content/78/2/372

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yanhui Xu, Wei Xu, Shi-Min Zhao
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30629-0

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
Qingqiu Huang, Clint Stalnecker, Chengliang Zhang, Lee A. McDermott, Prema Iyer, Jason O’Neill, Shawn Reimer, Richard A. Cerione and William P. Katt
http://www.jbc.org/content/early/2018/01/09/jbc.M117.810101.abstract

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Yann Cormerais, Pierre André Massard, Milica Vucetic, Sandy Giuliano, Eric Tambutté, Jerome Durivault, Valérie Vial, Hitoshi Endou, Michael F. Wempe, Scott K. Parks and Jacques Pouyssegur
http://www.jbc.org/content/early/2018/01/11/jbc.RA117.001342.abstract

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker & Renae M Ryan
https://www.nature.com/articles/s41467-017-02444-w

————————–
Glucose, lactate
—————————

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher P. Long, Maciek R. Antoniewicz & Nissim Hay
https://www.nature.com/articles/s41467-017-02733-4

Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
K Diehl, L-A Dinges, O Helm, N Ammar, D Plundrich, A Arlt, C Röcken, S Sebens & H Schäfer
https://www.nature.com/articles/onc2017299

Coordinated Regulation of Intracellular pH by Two Glucose Sensing Pathways in Yeast
Daniel G. Isom, Stephani C. Page, Leonard B. Collins, Nicholas J. Kapolka, Geoffrey J. Taghon and Henrik G. Dohlman
http://www.jbc.org/content/early/2017/12/28/jbc.RA117.000422.abstract

GLUCOSE TRANSPORTER-1 AS AN INDEPENDENT PROGNOSTIC MARKER FOR CANCER: A META-ANALYSIS
Zheng-Xiao Zhao, Lin-Wei Lu, Jian Qiu, Qiu-Ping Li, Fei Xu, Bao-Jun Liu, Jing-Cheng Dong,  and  Wei-Yi Gong
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18964&path%5B%5D=60791

———————————————
NAD, NADP, nucleotides
———————————————

Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Xu Qian, Xinjian Li, Lin Tan, Jong-Ho Lee, Yan Xia, Qingsong Cai, Yanhua Zheng, Hongxia Wang, Philip L. Lorenzi and Zhimin Lu
http://cancerdiscovery.aacrjournals.org/content/8/1/94

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors
Wenyun Lu, Lin Wang, Li Chen, Sheng Hui, and Joshua D. Rabinowitz
http://online.liebertpub.com/doi/10.1089/ars.2017.7014

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31874-0

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
Michael T McCarthy, Gerald Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Valli, Tomoyoshi Soga, Julie Adam and Christopher A O’Callaghan
http://www.jbc.org/content/early/2018/01/03/jbc.M117.809459.abstract

————–
Lipids
————–

LOW-DOSE STATIN TREATMENT INCREASES PROSTATE CANCER AGGRESSIVENESS
Alfredo Caro-Maldonado, Laura Camacho, Amaia Zabala-Letona, Verónica Torrano, Sonia Fernández-Ruiz, Kepa Zamacola-Bascaran, Leire Arreal, Lorea Valcárcel-Jiménez, Natalia Martín-Martín, Juana M. Flores, Ana R. Cortazar, Patricia Zúñiga-García, Amaia Arruabarrena-Aristorena, Fabienne Guillaumond, Diana Cabrera, Juan M. Falcón-Perez, Ana M. Aransay, Antonio Gomez-Muñoz, Mireia Olivan, Juan Morote,  and  Arkaitz Carracedo
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22217&path%5B%5D=70335

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
Tianyi Wang, Johannes Francois Fahrmann, Heehyoung Lee, Yi-Jia Li, Satyendra C. Tripathi, Chanyu Yue, Chunyan Zhang, Veronica Lifshitz, Jieun Song, Yuan Yuan, George Somlo, Rahul Jandial, David Ann, Samir Hanash, Richard Jove, Hua Yu
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30669-1

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER
Jonathan R. Friedman, Muthukumar Kannan, Alexandre Toulmay, Calvin H. Jan, Jonathan S. Weissman, William A. Prinz, Jodi Nunnari
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30984-X

————————
Hypoxia, HIF
————————

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia
Xiaodong Zhang, Alicia M Saarinen, Taro Hitosugi, Zhenghe Wang, Liguo Wang, Thai H Ho, Jun Liu
https://elifesciences.org/articles/31132

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
Jolieke G. van Oosterwijk, Daelynn R. Buelow, Christina D. Drenberg, Aksana Vasilyeva, Lie Li, Lei Shi, Yong-Dong Wang, David Finkelstein, Sheila A. Shurtleff, Laura J. Janke, Stanley Pounds, Jeffrey E. Rubnitz, Hiroto Inaba, Navjotsingh Pabla, and Sharyn D. Baker
https://www.jci.org/articles/view/91893

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL
Ji Ae Kim, Da Kyung Choi, Jung Sun Min, Inho Kang, Jin Chul Kim, Semi Kim and Jeong Keun Ahn
http://onlinelibrary.wiley.com/doi/10.1111/febs.14322/abstract

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice
Claire-Sophie Devignes, Yetki Aslan, Audrey Brenot, Audrey Devillers, Koen Schepers, Stéphanie Fabre, Jonathan Chou, Amy-Jo Casbon, Zena Werb, and Sylvain Provot
http://www.pnas.org/content/115/5/E992?etoc=

HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis
Hui-Huang Lai, Jie-Ning Li, Ming-Yang Wang, Hsin-Yi Huang, Carlo M. Croce, Hui-Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching-Feng Chiu, Mien-Chie Hung, Hiroshi I. Suzuki, and Pai-Sheng Chen
https://www.jci.org/articles/view/89212

———————–
Starvation
———————–

Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis
Ha Yin Lee , Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H. Shawn Je, Egon Ogris, David M. Virshup, Koji Itahana
http://stke.sciencemag.org/content/11/512/eaam7893

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
Xiao-xue Li, Zhi-jing Wang, Yu Zheng, Yun-feng Guan, Peng-bo Yang, Xiang Chen, Cong Peng, Jian-ping He, Yuan-li Ai, Sheng-fu Wu, Kun-Yi Chien, Qiao Wu, Hang-zi Chen
http://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30001-7

TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation
Lei Sun, Zhaoyue Meng, Yifei Zhu, Jun Lu, Zhichao Li et al.
https://www.nature.com/articles/cdd2017166

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy
Heeseon An & J. Wade Harper
http://www.nature.com/articles/s41556-017-0007-x

Lipid droplet biogenesis is spatially coordinated at ER–vacuole contacts under nutritional stress
Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J Ryan Feathers and W Mike Henne
http://EMBOr.embopress.org/content/19/1/57?etoc

Glucose deprivation induces primary cilium formation through mTORC1 inactivation
Kengo Takahashi, Tomoaki Nagai, Shuhei Chiba, Keiko Nakayama and Kensak Mizuno
http://jcs.biologists.org/content/131/1/jcs213181?etoc

Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms
L-N Fu, Y-Q Wang, J Tan, J Xu, Q-Y Gao, Y-X Chen& J-Y Fang
https://www.nature.com/articles/onc2017345

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin
Avinash Persaud, Yann Cormerais, Jacques Pouyssegur and Daniela Rotin
http://jcs.biologists.org/content/131/1/jcs211755?etoc

Puromycin labeling does not allow protein synthesis to be measured in energy-starved cells
Ran Marciano, Gabriel Leprivier & Barak Rotblat
https://www.nature.com/articles/s41419-017-0056-x

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, Scott J. Dixon
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31914-9

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Mitochondria
———————-

A metabolic function of FGFR3-TACC3 gene fusions in cancer
Véronique Frattini, Stefano M. Pagnotta, Tala, Jerry J. Fan, Marco V. Russo, Sang Bae Lee, Luciano Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M. Castano, Luigi Cerulo, Delphine C. M. Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S. J. Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella & Antonio Iavarone
https://www.nature.com/articles/nature25171

Mitochondria are physiologically maintained at close to 50 °C
Dominique Chrétien, Paule Bénit, Hyung-Ho Ha, Susanne Keipert, Riyad El-Khoury, Young-Tae Chang, Martin Jastroch, Howard T. Jacobs, Pierre Rustin, Malgorzata Rak
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003992

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance
Allyson L. Anding, Chunxin Wang, Tsun-Kai Chang, Danielle A. Sliter, Christine M. Powers, Kay Hofmann, Richard J. Youle, Eric H. Baehrecke
http://www.cell.com/current-biology/fulltext/S0960-9822(17)31589-0

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra
https://www.nature.com/articles/s41467-017-02787-4

—————————-
mTOR / AMPK
—————————-

mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
Marta Brandt, Tatiana P. Grazioso, Mohamad-Ali Fawal, Krishna S. Tummala, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Cristian Perna, Nabil Djouder
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30674-5

Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases
Kim Hou Chia, Tomoyuki Fukuda, Fajar Sofyantoro, Takato Matsuda, Takamitsu Amai, Kazuhiro Shiozaki
https://elifesciences.org/articles/30880

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer
Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Avi Kumar, Guojing Zhang, Youna Ha, Dan Li, Gina N. Alesi, Yibin Kang, Lu Zhou, Wen-Mei Yu, Kelly R. Magliocca, Fadlo R. Khuri, Cheng-Kui Qu, Christian Metallo, Taofeek K. Owonikoko, Sumin Kang
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30884-5

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IDH
————

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Rui Su, Lei Dong, Chenying Li, Sigrid Nachtergaele, Mark Wunderlich, Ying Qing, Xiaolan Deng, Yungui Wang, Xiaocheng Weng, Chao Hu, Mengxia Yu, Jennifer Skibbe, Qing Dai, Dongling Zou, Tong Wu, Kangkang Yu, Hengyou Weng, Huilin Huang, Kyle Ferchen, Xi Qin, Bin Zhang, Jun Qi, Atsuo T. Sasaki, David R. Plas, James E. Bradner, Minjie Wei, Guido Marcucci, Xi Jiang, James C. Mulloy, Jie Jin, Chuan He, Jianjun Chen
http://www.cell.com/cell/fulltext/S0092-8674(17)31382-X

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner and Hai Yan
http://cancerres.aacrjournals.org/content/78/1/36

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Miscellaneous
—————————–

A Landscape of Metabolic Variation across Tumor Types
Ed Reznik, Augustin Luna, Bulent Arman Aksoy, Eric Minwei Liu, Konnor La, Irina Ostrovnaya, Chad J. Creighton, A. Ari Hakimi, Chris Sander
http://www.cell.com/pb-assets/journals/research/cell-systems/CELS394.pdf

Fenofibrate prevents skeletal muscle loss in mice with lung cancer
Marcus D. Goncalves, Seo-Kyoung Hwang, Chantal Pauli, Charles J. Murphy, Zhe Cheng, Benjamin D. Hopkins, David Wu, Ryan M. Loughran, Brooke M. Emerling, Guoan Zhang, Douglas T. Fearon and Lewis C. Cantley
http://www.pnas.org/content/115/4/E743?etoc=

METABOLOMIC ALTERATIONS IN INVASIVE DUCTAL CARCINOMA OF BREAST: A COMPREHENSIVE METABOLOMIC STUDY USING TISSUE AND SERUM SAMPLES
Tushar H. More, Sourav RoyChoudhury, Joel Christie, Khushman Taunk, Anupama Mane, Manas K. Santra, Koel Chaudhury,  and  Srikanth Rapole
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23626&path%5B%5D=74389

———————
Reviews
———————

AMPK: guardian of metabolism and mitochondrial homeostasis
Sebastien Herzig & Reuben J. Shaw
https://www.nature.com/articles/nrm.2017.95?lang=en

Regulation of redox balance in cancer and T cells
Hyewon Kong and Navdeep S. Chandel
http://www.jbc.org/content/early/2018/01/03/jbc.TM117.000257.abstract

Metabolic rewiring in mutant Kras lung cancer
Emma M. Kerr and Carla P. Martins
http://onlinelibrary.wiley.com/doi/10.1111/febs.14125/full

Metabolism and Transcription in Cancer: Merging Two Classic Tales
Natalia Martín-Martín, Arkaitz Carracedo and Verónica Torrano
https://www.frontiersin.org/articles/10.3389/fcell.2017.00119/full

Targeting the Warburg effect for Cancer Treatment: Ketogenic Diets for Management of Glioma.
Poff A, Kourtnik A, Egan KM, Sahebjum S, D’Agostino D, Kumar NB
http://www.sciencedirect.com/science/article/pii/S1044579X17301244

Cell-Autonomous Metabolic Reprogramming in Hypoxia
Luana Schito, Sergio Rey
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30197-6

The HIF and other quandaries in VHL disease
D Tarade and M Ohh
https://www.nature.com/articles/onc2017338

Lactate metabolism: historical context, prior misinterpretations, and current understanding
Brian S. Ferguson, Matthew J. Rogatzki, Matthew L. Goodwin, Daniel A. Kane, Zachary Rightmire, L. Bruce Gladden
https://link.springer.com/article/10.1007/s00421-017-3795-6

Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
Masa Zdralevic, Ibtissam Marchiq, Monique Meyenberg Cunha de Padua, Scott Parks, and Jacques Pouysségur
https://www.frontiersin.org/articles/10.3389/fonc.2017.00313/full

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Mark A Hawk and Zachary T Schafer
http://www.jbc.org/content/early/2018/01/16/jbc.TM117.000260.abstract

The redox requirements of proliferating mammalian cells
Aaron M Hosios and Matthew G Vander Heiden
http://www.jbc.org/content/early/2018/01/16/jbc.TM117.000239.abstract

The hypoxic tumour microenvironment
Varvara Petrova, Margherita Annicchiarico-Petruzzelli, Gerry Melino & Ivano Amelio
https://www.nature.com/articles/s41389-017-0011-9

Lipid-mediated signals that regulate mitochondrial biology
Jason R Nielson and Jared P Rutter
http://www.jbc.org/content/early/2018/01/18/jbc.R117.001655.abstract

Spermidine in health and disease
Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer
http://science.sciencemag.org/content/359/6374/eaan2788


Special Issue in Seminars in Cancer Biology
Mitochondria in Cancer
https://www.sciencedirect.com/science/journal/1044579X
Editorial by Keshav K Singh, Josephine S. Modica-Napolitano: http://www.sciencedirect.com/science/article/pii/S1044579X17302614

Research Topic in  Front. Endocrinol
Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
https://www.frontiersin.org/research-topics/4124/metabolic-adaptation-to-cell-growth-and-proliferation-in-normal-and-pathological-conditions
Editorial:  Albert Giralt and Lluis Fajas
https://www.frontiersin.org/articles/10.3389/fendo.2017.00362/full

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Comments, other
——————————

Glutamate Dehydrogenase to the Rescue
Jonathan L. Coloff
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30967-X

Fountain of youth of pancreatic cancer cells: the extracellular matrix
Victoire Gouirand & Sophie Vasseur
https://www.nature.com/articles/s41420-017-0004-7

Journal Club: Mitochondria: back to the future
Navdeep S. Chandel
https://www.nature.com/articles/nrm.2017.133

Profile of David M. Sabatini
Jennifer Viegas
http://www.pnas.org/content/115/3/438

Mutant IDH1R132H Induces Transcriptional and Epigenomic Reprogramming
http://cancerdiscovery.aacrjournals.org/content/8/1/10.2

R-2HG Targets FTO to Increase m6A Levels and Suppress Tumor Growth
http://cancerdiscovery.aacrjournals.org/content/8/2/137.2

SRPK2 Acts Downstream of MTORC1 to Promote De Novo Lipogenesis
http://cancerdiscovery.aacrjournals.org/content/8/1/OF18

mTORC2-Driven Lipid Synthesis Promotes Liver Tumorigenesis
http://cancerdiscovery.aacrjournals.org/content/8/2/OF9

FGFR3–TACC3 Activates Mitochondrial Respiration via PIN4 Phosphorylation
http://cancerdiscovery.aacrjournals.org/content/8/2/139.1

Glutaminolysis Drives Lung Cancer Metastasis via the PLAG1–GDH1 Axis
http://cancerdiscovery.aacrjournals.org/content/8/2/OF11

MetaboList – December 2018

—————————————————
Glycolysis and glucose sensing
—————————————————

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect
Yang Wang, Jia Liu, Xin Jin, Dapeng Zhang, Dongxue Li, Fengqi Hao, Yunpeng Feng, Shan Gu, Fanlin Meng, Miaomiao Tian, Yi Zheng, Ling Xin, Xinbo Zhang, Xue Han, L. Aravind, and Min Wei
http://www.pnas.org/content/114/52/13732.abstract.html

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells
Yin P Hung, Carolyn Teragawa, Nont Kosaisawe, Taryn E Gillies, Michael Pargett, Marta Minguet, Kevin Distor, Briana L Rocha-Gregg, Jonathan L Coloff, Mark A Keibler, Gregory Stephanopoulos, Gary Yellen, Joan S Brugge and John G Albeck
https://elifesciences.org/articles/27293

The Std1 Activator of the Snf1/AMPK Kinase Controls Glucose Response in Yeast by a Regulated Protein Aggregation
Kobi Simpson-Lavy, Tianchang Xu, Mark Johnston, Martin Kupiec
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30875-4

Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways
Yue Hu, Ivana Semova, Xiaowei Sun, Hong Kang, Satyapal Chahar, Anthony N Hollenberg, David Masson, Matthew D Hirschey, Ji Miao and Sudha B Biddinger
http://www.jbc.org/content/early/2017/12/08/jbc.M117.782557.abstract

GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND TRANSKETOLASE MODULATE BREAST CANCER CELL METABOLIC REPROGRAMMING AND CORRELATE WITH POOR PATIENT OUTCOME
Adrián Benito, Ibrahim H. Polat, Véronique Noé, Carlos J. Ciudad, Silvia Marin,  and  Marta Cascante
https://doi.org/10.18632/oncotarget.21601

PYRUVATE KINASE M2 PHOSPHORYLATES H2AX AND PROMOTES GENOMIC INSTABILITY IN HUMAN TUMOR CELLS
Li Xia, Kang Qin, Xin-Ran Wang, Xiao-Ling Wang, Ai-Wu Zhou, Guo-Qiang Chen,  and  Ying Lu
https://doi.org/10.18632/oncotarget.22621

HIGH GLUCOSE ENHANCES THE METASTATIC POTENTIAL OF TONGUE SQUAMOUS CELL CARCINOMA VIA THE PKM2 PATHWAY
Wei Wang, Qianting He, Wangxiang Yan, Jingjing Sun, Zujian Chen, Zhonghua Liu, Zhiyuan Lu, Jinsong Hou, Yisen Shao, Xiaofeng Zhou,  and  Anxun Wang
https://doi.org/10.18632/oncotarget.22907

Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells
Maria Rosaria Ambrosio, Vittoria D’Esposito, Valerio Costa, Domenico Liguoro, Francesca Collina, Monica Cantile, Nella Prevete, Carmela Passaro, Giusy Mosca, Michelino De Laurentiis, Maurizio Di Bonito, Gerardo Botti, Renato Franco, Francesco Beguinot, Alfredo Ciccodicola, and Pietro Formisano
https://doi.org/10.18632/oncotarget.22552

The glucose and lipid metabolism reprogramming is gradedependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell viability and proliferation
Cristina Bianchi, Chiara Meregalli, Silvia Bombelli, Vitalba Di Stefano, Francesco Salerno, Barbara Torsello, Sofia De Marco, Giorgio Bovo, Ingrid Cifola, Eleonora Mangano, Cristina Battaglia, Guido Strada, Giuseppe Lucarelli, Robert H. Weiss,  and  Roberto A. Perego
https://doi.org/10.18632/oncotarget.23056

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Amino acid metabolism and starvation
——————————————————————-

Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells
Sunyoung Hwang, H. Tobias Gustafsson, Ciara O’Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, Eduardo M. Torres
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31787-4

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis
Ming Yue, Jue Jiang, Peng Gao, Hudan Liu, Guoliang Qing
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31798-9

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
Evan C. Lien, Laura Ghisolfi, Renee C. Geck, John M. Asara, Alex Toker
http://stke.sciencemag.org/content/10/510/eaao6604

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero & Jim C. Norman
https://www.nature.com/articles/s41467-017-02101-2

ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
Juan F. Linares, Thekla Cordes, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Christopher S. Ahn, Elias A. Castilla, Jorge Moscat, Christian M. Metallo, Maria T. Diaz-Meco
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30552-1

CHAC1 DEGRADATION OF GLUTATHIONE ENHANCES CYSTINE-STARVATION-INDUCED NECROPTOSIS AND FERROPTOSIS IN HUMAN TRIPLE NEGATIVE BREAST CANCER CELLS VIA THE GCN2-EIF2Α-ATF4 PATHWAY
Meng-Shian Chen, Sheng-Fan Wang, Chih-Yi Hsu, Pen-Hui Yin, Tien-Shun Yeh, Hsin-Chen Lee,  and  Ling-Ming Tseng
https://doi.org/10.18632/oncotarget.23055

In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors
Lucia Salamanca-Cardona, Hardik Shah, Alex J. Poot, Fabian M. Correa, Valentina Di Gialleonardo, Hui Lui, Vesselin Z. Miloushev, Kristin L. Granlund, Sui S. Tee, Justin R. Cross, Craig B. Thompson, Kayvan R. Keshari
http://www.cell.com/cell-metabolism/abstract/S1550-4131(17)30613-7

A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity
Canrong Wu, Mengzhu Zheng, Suyu Gao, Shanshan Luan, Li Cheng, Liqing Wang, Jiachen Li, Lixia Chen,  and  Hua Li
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23058

IDENTIFICATION OF A CYTOGENETIC AND MOLECULAR SUBGROUP OF ACUTE MYELOID LEUKEMIAS SHOWING SENSITIVITY TO L-ASPARAGINASE
Salvatore Nicola Bertuccio, Salvatore Serravalle, Annalisa Astolfi, Annalisa Lonetti, Valentina Indio, Anna Leszl,Andrea Pession, and  Fraia Melchionda
https://doi.org/10.18632/oncotarget.18565

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors
Charalambos Kaittanis, Chrysafis Andreou, Haley Hieronymus, Ninghui Mao, Catherine A. Foss, Matthias Eiber, Gregor Weirich, Palak Panchal, Anuradha Gopalan, Juan Zurita, Samuel Achilefu, Gabriela Chiosis, Vladimir Ponomarev, Markus Schwaiger, Brett S. Carver, Martin G. Pomper and Jan Grimm
http://jem.rupress.org/content/215/1/159?etoc

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Lipids
——————-

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
Gina Lee, Yuxiang Zheng, Sungyun Cho, Cholsoon Jang, Christina England, Jamie M. Dempsey, Yonghao Yu, Xiaolei Liu, Long He, Paola M. Cavaliere, Andre Chavez, Erik Zhang, Meltem Isik, Anthony Couvillon, Noah E. Dephoure, T. Keith Blackwell, Jane J. Yu, Joshua D. Rabinowitz, Lewis C. Cantley, John Blenis
http://www.cell.com/cell/fulltext/S0092-8674(17)31263-1

mTORC2 Promotes Tumorigenesis via Lipid Synthesis
Yakir Guri, Marco Colombi, Eva Dazert, Sravanth K. Hindupur, Jason Roszik, Suzette Moes, Paul Jenoe, Markus H. Heim, Isabelle Riezman, Howard Riezman, Michael N. Hall
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30514-7

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence
Marcos Rios Garcia, Brigitte Steinbauer, Kshitij Srivastava, Mahak Singhal, Frits Mattijssen, Adriano Maida, Sven Christian, Holger Hess-Stumpp, Hellmut G. Augustin, Karin Müller-Decker, Peter P. Nawroth, Stephan Herzig, Mauricio Berriel Diaz
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30570-3

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism
Elena Ioana Braicu, Silvia Darb-Esfahani, […], and Mika Hilvo
https://doi.org/10.18632/oncotarget.22076

Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
Yue-Zhen Deng, Zhen Cai, Shuo Shi, Hao Jiang, Yu-Rong Shang, Ning Ma, Jing-Jing Wang, Dong-Xian Guan, Tian-Wei Chen, Ye-Fei Rong, Zhen-Yu Qian, Er-Bin Zhang, Dan Feng, Quan-Li Zhou, Yi-Nan Du, Dong-Ping Liu, Xing-Xu Huang, Lu-Ming Liu, Eugene Chin, Dang-Sheng Li, Xiao-Fan Wang, Xue-Li Zhang and Dong Xie
http://jem.rupress.org/content/215/1/177?etoc

——————————————–
Mitochondria / Nucleotides
——————————————–

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive D’Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R. Griffiths,  Christian Frezza
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31412-2

Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
Laia Miret-Casals, David Sebastián, José Brea, Eva M. Rico-Leo, Manuel Palacín, Pedro M. Fernández-Salguero, M. Isabel Loza, Fernando Albericio,  Antonio Zorzano
http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30428-2

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
Michael T McCarthy, Gerald Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Vali, Tomoyoshi Soga, Julie Adam and Christopher A O’Callaghan
http://www.jbc.org/content/early/2017/12/26/jbc.M117.809459.abstract

Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
Amanda E. Brinker, Carolyn J. Vivian, Devin C. Koestler, Trevor T. Tsue, Roy A. Jensen and Danny R. Welch
http://cancerres.aacrjournals.org/content/77/24/6941

Alteration of mitochondrial biogenesis promotes disease progression in multiple myeloma
Xin Zhan, Wenjie Yu, Reinaldo Franqui-Machin, Melissa L. Bates, Kalyan Nadiminti, Huojun Cao, Brad A. Amendt, Yogesh Jethava, Ivana Frech, Fenghuang Zhan, and Guido Tricot
https://doi.org/10.18632/oncotarget.22740

————–
mTOR
————–

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
Ming-Yuan Su, Kyle L. Morris, Do Jin Kim, Yangxue Fu, Rosalie Lawrence, Goran Stjepanovic, Roberto Zoncu, James H. Hurley
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30791-8

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J. Yang, Meredith Miller, Angela Yang, Ankita Dhar & Nikola P. Pavletich
https://www.nature.com/articles/nature25023

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients
Mark R Woodford, Rebecca A Sager, Elijah Marris, Diana M Dunn, Adam R Blanden, Ryan L Murphy, Nicholas Rensing, Oleg Shapiro, Barry Panaretou, Chrisostomos Prodromou, Stewart N Loh, David H Gutmann, Dimitra Bourboulia, Gennady Bratslavsky, Michael Wong, View ORCID ProfileMehdi Mollapour
http://emboj.embopress.org/content/36/24/3650?etoc

——————————————————
Angiogenesis / hypoxia / starvation
——————————————————

Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis
Ward Celus, Giusy Di Conza, Ana Isabel Oliveira, Manuel Ehling, Bruno M. Costa, Mathias Wenes, Massimiliano Mazzone
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31671-6

The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia
G. Sgarbi, S. Barbato, A. Costanzini, G. Solaini, A. Baracca
https://www.sciencedirect.com/science/article/pii/S0005272817301597

Stress-response transcription factors Msn2 and Msn4 couple TORC2-Ypk1 signaling and mitochondrial respiration to ATG8 gene expression and autophagy
[yeast]
Ariadne Vlahakis, Nerea Lopez Muniozguren & Ted Powers
http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1356949

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Epigenetics / IDH
——————————-

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation
Suman Das, Frederic Morvan, Giulio Morozzi, Benjamin Jourde, Giulia C. Minetti, Peter Kahle, Helene Rivet, Pascale Brebbia, Gauthier Toussaint, David J. Glass, Mara Fornaro
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31675-3

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
Sevin Turcan, Vladimir Makarov, Julian Taranda, Yuxiang Wang, Armida W. M. Fabius, Wei Wu, Yupeng Zheng, Nour El-Amine, Sara Haddock, Gouri Nanjangud, H. Carl LeKaye, Cameron Brennan, Justin Cross, Jason T. Huse, Neil L. Kelleher, Pavel Osten, Craig B. Thompson & Timothy A. Chan
https://www.nature.com/articles/s41588-017-0001-z

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Miscellaneous
—————————

Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling
Sriram Chandrasekaran, Jin Zhang, Zhen Sun, Li Zhang, Christian A. Ross, Yu-Chung Huang, John M. Asara, Hu Li, George Q. Daley, James J. Collins
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31027-6

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming
Prachi Mishra, Wei Tang, Vasanta Putluri, Tiffany H. Dorsey, Feng Jin, Fang Wang, Donewei Zhu, Lauren Amable, Tao Deng, Shaofei Zhang, J. Keith Killian, Yonghong Wang, Tsion Z. Minas, Harry G. Yfantis, Dong H. Lee, Arun Sreekumar, Michael Bustin, Wei Liu, Nagireddy Putluri, and Stefan Ambs
https://www.jci.org/articles/view/93815#.WiftNPQ8t4M.facebook

Energy metabolism in glioblastoma stem cells: PPARα a metabolic adaptor to intratumoral microenvironment
Alessia Fidoamore, Loredana Cristiano, Chiara Laezza, Renato Galzio, Elisabetta Benedetti, Benedetta Cinque, Andrea Antonosante, Michele d’Angelo, Vanessa Castelli, Maria Grazia Cifone, Rodolfo Ippoliti, Antonio Giordano,  and  Annamaria Cimini
https://doi.org/10.18632/oncotarget.19086

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Reviews
—————–

Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
Christopher T. Walsh, Benjamin P. Tu, and Yi Tang
http://pubs.acs.org/doi/10.1021/acs.chemrev.7b00510

AMPK: Sensing Glucose as well as Cellular Energy Status
Sheng-Cai Lin, D. Grahame Hardie
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30622-8

Advances in Hypoxia-Inducible Factor Biology
Hani Choudhry, Adrian L. Harris
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30617-4

Ribosome biogenesis in cancer: new players and therapeutic avenues
Joffrey Pelletier, George Thomas & Sinisa Volarevic
https://www.nature.com/articles/nrc.2017.104

Sphingolipid metabolism in cancer signalling and therapy
Besim Ogretmen
https://www.nature.com/articles/nrc.2017.96

Mitochondrial metabolism and cancer
Paolo Ettore Porporato, Nicoletta Filigheddu, José Manuel Bravo-San Pedro, Guido Kroemer & Lorenzo Galluzzi
https://www.nature.com/articles/cr2017155

Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease
Nabil Rabhi, Sarah Anissa Hannou, Philippe Froguel and Jean-Sébastien Annicotte
https://www.frontiersin.org/articles/10.3389/fendo.2017.00304/full

Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity
Scott M. Seki and Alban Gaultier
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01549/full

Asparagine synthetase: Function, structure, and role in disease
Carrie L. Lomelino, Jacob T. Andring, Robert McKenna and Michael S. Kilberg
http://www.jbc.org/content/292/49/19952.abstract.html

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
Niamh M. C. Connolly, Pierre Theurey, […] Jochen H. M. Prehn
https://www.nature.com/articles/s41418-017-0020-4

Lipoic acid metabolism and mitochondrial redox regulation
Ashley D Solmonson and Ralph J. DeBerardinis
http://www.jbc.org/content/early/2017/11/29/jbc.TM117.000259.abstract

Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD
Olivia I. Kolenc and Kyle P. Quinn.
http://online.liebertpub.com/doi/10.1089/ars.2017.7451

Do lipids shape the eukaryotic cell cycle?
Samuel Furse, Gemma C. Shearman
https://www.sciencedirect.com/science/article/pii/S1388198117302032

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Comments
——————–

When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade
Mengrou Shan, Costas A. Lyssiotis
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30676-9

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle
Inmaculada Martínez-Reyes, Navdeep S. Chandel
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30673-3

A cholesterol-sensing mechanism unfolds
William A. Prinz
http://www.jbc.org/content/292/49/19974.abstract.html

Glut3 Addiction: A Druggable Vulnerability in Glioblastoma
Severa Bunda, Gelareh Zadeh, Kenneth D. Aldape
http://www.cell.com/cancer-cell/abstract/S1535-6108(17)30520-2

Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex
Jacqueline Cherfils
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30886-9

PSMA brings new flavors to PI3K signaling: A role for glutamate in prostate cancer
Lavinia Palamiuc and Brooke M. Emerling
http://jem.rupress.org/content/215/1/17?etoc

Keap1 Loss Drives Kras-Mutant Lung Cancer and Glutaminolysis Dependency
http://cancerdiscovery.aacrjournals.org/content/7/12/OF8

Glucose Indirectly Fuels the TCA Cycle in Tumors via Lactate
http://cancerdiscovery.aacrjournals.org/content/7/12/OF9

Breast Cancer Cells Recycle Ammonia to Generate Amino Acids
http://cancerdiscovery.aacrjournals.org/content/7/12/1364.2

Lactate Fuels the TCA Cycle in Non–Small Cell Lung Cancer
http://cancerdiscovery.aacrjournals.org/content/7/12/OF10

SLC38A9 Links mTORC1 Activity to Lysosomal Amino Acid Release
http://cancerdiscovery.aacrjournals.org/content/7/12/OF12

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Resources
———————

Conference on Cancer Metabolism organized by A Carracedo, N Chandel, R DeBerardinins, J Seoane, J Carmona and A. Efeyan in Bilbao, Spain, 09-11 Oct 2018.
https://www.eacr.org/conference/cancermetabolism2018/scientific-programme

Conference on Metabolism in Cancer and Stromal Cells  Peter Carmeliet, Sarah-Maria Fendt, Massimiliano Mazzone,
Jo Van Ginderachter, Bart Ghesquière in Leuven, Belgium, 26-27 Nov 2018
https://vibconferences.be/event/metabolism-in-cancer-and-stromal-cells-2nd-edition

LinkedIn group / job posts
https://www.linkedin.com/groups/3694095

Facebook Cancer Metabolism page
https://www.facebook.com/CancerMetabolism

MetaboList – November 2017

———————————————-
Methods/Global approaches
———————————————-

Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing
Ramon C. Sun, Teresa W.-M. Fan, Pan Deng,  Richard M. Higashi, Andrew N. Lane, Anh-Thu Le, Timothy L. Scott, Qiushi Sun, Marc O. Warmoes & Ye Yang
https://www.nature.com/articles/s41467-017-01518-z

Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments
Anne Miller,  Csörsz Nagy, Bernhard Knapp, Johannes Laengle, Elisabeth Ponweiser, Marion Groeger, Philipp Starkl, Michael Bergmann, Oswald Wagner, Arvand Haschem
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30499-0

Metabolic Profiling of healthy and cancerous tissues in 2D and 3D
Shonagh Russell, Jonathan Wojtkowiak, Andy Neilson & Robert J. Gillies
https://www.nature.com/articles/s41598-017-15325-5

High-throughput metabolic profiling based on small amount of hepatic cells
Zhou, Lina; Yin, Peiyuan; Luo, Ping; Tang, Ling; Wang, Zhichao; Gao, Peng; Piao, Hailong; Lu, Xin; Xu, Guowang
http://onlinelibrary.wiley.com/doi/10.1002/elps.201600539/full

A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs
Yumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano, Michiyuki Matsuda
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31593-0

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Amino acids and ammonia
———————————————–

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
Monther Abu-Remaileh, Gregory A. Wyant, Choah Kim, Nouf N. Laqtom, Maria Abbasi, Sze Ham Chan, Elizaveta Freinkman, David M. Sabatini
http://science.sciencemag.org/content/358/6364/807

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Jessica B. Spinelli, Haejin Yoon, Alison E. Ringel, Sarah Jeanfavre, Clary B. Clish, Marcia C. Haigis
http://science.sciencemag.org/content/358/6365/941

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Simon Raffel, Mattia Falcone […] Andreas Trumpp
https://www.nature.com/articles/nature24294

Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging
Omran Abu Aboud, Samy L. Habib, Josephine Trott, Benjamin Stewart, Sitai Liang, Abhijit J. Chaudhari, Julie Sutcliffe and Robert H. Weiss
http://cancerres.aacrjournals.org/content/77/23/6746

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Rodrigo Romero, Volkan I Sayin[…],Thales Papagiannakopoulos
http://www.nature.com/nm/journal/v23/n11/full/nm.4407.html

PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma
Hirofumi Yoshino, Nijiro Nohata, Kazutaka Miyamoto, Masaya Yonemori, Takashi Sakaguchi, Satoshi Sugita, Toshihiko Itesako, Satoshi Kofuji, Masayuki Nakagawa, Rajvir Dahiya and Hideki Enokida
http://cancerres.aacrjournals.org/content/77/22/6321

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes
Thai Q. Tran, Mari B. Ishak Gabra, Xazmin H. Lowman, Ying Yang, Michael A. Reid, Min Pan, Timothy R. O’Connor, Mei Kong
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002810

ENDOGENOUS GLUTAMINE DECREASE IS ASSOCIATED WITH PANCREATIC CANCER PROGRESSION
Cecilia Roux, Chiara Riganti, Sammy Ferri Borgogno, Roberta Curto, Claudia Curcio, Valeria Catanzaro, Giuseppe Digilio, Sergio Padovan, Maria Paola Puccinelli, Monica Isabello, Silvio Aime, Paola Cappello,  and  Francesco Novelli
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20545&path%5B%5D=65492

The arginine metabolome in Acute Lymphoblastic Leukemia can be targeted by the PEG-recombinant Arginase I BCT-100
Carmela De Santo, Sarah Booth, Ashley Vardon, Antony Cousins, Vanessa Tubb, Tracey Perry, Boris Noyvert, Andrew Beggs, Margaret Ng, Christina Halsey, Pamela Kearns, Paul Cheng, Francis Mussai
http://onlinelibrary.wiley.com/doi/10.1002/ijc.31170/full/

LC-MS-BASED METABOLOMICS REVEALED SLC25A22 AS AN ESSENTIAL REGULATOR OF ASPARTATE-DERIVED AMINO ACIDS AND POLYAMINES IN KRAS-MUTANT COLORECTAL CANCER
Xiaona Li, Arthur C.K. Chung, Shangfu Li, Lilan Wu, Jiaying Xu, Jun Yu, Chichun Wong,  and  Zongwei Cai
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21093&path%5B%5D=67162

———————————
Glucose and lactate
———————————

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation
Changmin Peng, Yue Zhu, Wanjun Zhang, Qinchao Liao, Yali Chen, Xinyuan Zhao, Qiang Guo, Pan Shen, Bei Zhen, Xiaohong Qian, Dong Yang, Jin-San Zhang, Dongguang Xiao, Weijie Qin, Huadong Pei
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30759-1

CDK8 Kinase Activity Promotes Glycolysis
Matthew D. Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A. Bonner, Amanda A. Hill, Kelly D. Sullivan, Joaquín M. Espinosa
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31505-X

Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells
A G Trinidad, N Whalley, R Rowlinson, O Delpuech, P Dudley, C Rooney and S E Critchlow
http://www.nature.com/onc/journal/v36/n44/abs/onc2017224a.html

Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia
Monique Cunha de Padua, Giulia Delodi, Milica Vučetić, Jérôme Durivault, Valérie Vial, Pascale Bayer, Guilhermina Rodrigues Noleto, Nathalie M. Mazure, Maša Ždralević and Jacques Pouysségur
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=21007&path%5B1%5D=66903

MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases
SilviaLemma, GemmaDi Pompo, Paolo E. Porporato, Martina Sboarina, Shonagh Russell, Robert J.Gillies, Nicola Baldini, Pierre Sonveaux, Sofia Avnet
http://www.sciencedirect.com/science/article/pii/S0925443917303125?via%3Dihub

LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism
Xin Zheng, Han Han, Guang‐Ping Liu, Yan‐Xiu Ma, Ruo‐Lang Pan, Ling‐Jie Sang, Rui‐Hua Li, Luo‐Jia Yang, Jeffrey R Marks, Wenqi Wang and Aifu Lin
http://EMBOJ.embopress.org/content/36/22/3325?etoc

SALL4 promotes glycolysis and chromatin remodeling via modulating HP1α-Glut1 pathway
J Kim, S Xu, L Xiong, L Yu, X Fu and Y Xu
https://www.nature.com/articles/onc2017265

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P53 and metabolism
————————————

The p53‐inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation
Muhammad Riaz Khan, Shaoxun Xiang, Zhiyin Song and Mian Wu
http://emboj.embopress.org/content/36/23/3483?etoc

Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism
Matilda Eriksson, Gorbatchev Ambroise, Amanda Tomie Ouchida, Andre Lima Queiroz, Dominique Smith, Alfredo Gimenez-Cassina, Marcin P. Iwanicki, Patricia A. Muller, Erik Norberg and Helin Vakifahmetoglu-Norberg
http://mcb.asm.org/content/37/24/e00328-17.abstract?etoc

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma
Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai & David A Nathanson
https://www.nature.com/articles/nm.4418

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Lipids
———–

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L. Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I. Rini, Steven Campbell & Scott M. Welford
https://www.nature.com/articles/s41467-017-01965-8

Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia
E J Gallagher, Z Zelenko, B A Neel, I M Antoniou, L Rajan, N Kase and D LeRoith
https://www.nature.com/articles/onc2017247

Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids
Caroline H. Johnson, Antonio F. Santidrian, Sarah E. LeBoeuf, Michael E. Kurczy, Nicholas J. W. Rattray, Zahra Rattray, Benedikt Warth, Melissa Ritland, Linh T. Hoang, Celine Loriot, Jason Higa, James E. Hansen, Brunhilde H. Felding and Gary Siuzdak
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0171-2

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism
Lu Wang, Clayton K. Collings, Zibo Zhao, Kira Alia Cozzolino, Quanhong Ma, Kaiwei Liang, Stacy A. Marshall, Christie C. Sze, Rintaro Hashizume, Jeffrey Nicholas Savas and Ali Shilatifard
http://genesdev.cshlp.org/content/31/20/2056.abstract?etoc

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Mitochondria
————————–

Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells
A G Trinidad, N Whalley, R Rowlinson, O Delpuech, P Dudley, C Rooney and S E Critchlow
https://www.nature.com/articles/onc2017224

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism
E Cuyàs, S Fernández-Arroyo, S Verdura, R Á-F García, J Stursa, L Werner, E Blanco-González, M Montes-Bayón, J Joven, B Viollet, J Neuzil & J A Menendez
https://www.nature.com/articles/onc2017367

PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs
Sylvia Andrzejewski, Eva Klimcakova, Radia M. Johnson, Sébastien Tabariès, Matthew G. Annis, Shawn McGuirk, Jason J. Northey, Valérie Chénard, Urshila Sriram, David J. Papadopoli, Peter M. Siegel, Julie St-Pierre
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30557-0

Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation
Laura E. Jackson, Sucheta Kulkarni, Huabo Wang, Jie Lu, James M. Dolezal, Sivakama S. Bharathi, Sarangarajan Ranganathan, Mulchand S. Patel, Rahul Deshpande, Frances Alencastro, Stacy G. Wendell, Eric S. Goetzman, Andrew W. Duncan and Edward V. Prochownik
http://cancerres.aacrjournals.org/content/77/21/5795

A conserved mammalian mitochondrial isoform of acetyl-CoA carboxylase
ACC1 provides the malonyl-CoA essential for mitochondrial biogenesis in tandem with ACSF3
Geoffray Monteuuis, Fumi Suomi, Juha M. Kerätär, Ali J. Masud and Alexander J. Kastaniotis
http://www.biochemj.org/content/474/22/3783?etoc

SDHC promoter methylation, a novel pathogenic mechanism in parasympathetic paragangliomas
Cristóbal Bernardo-Castiñeira, Nuria Valdés, Marta I Sierra, Inés Sáenz-de-Santa-María, Gustavo F Bayón, Raúl F Perez, Agustín F Fernández, Mario F Fraga, Aurora Astudillo, Rafael Menéndez, Belén Fernández, Maribel del Olmo Carlos Suarez, María-Dolores Chiara
https://academic.oup.com/jcem/article-abstract/doi/10.1210/jc.2017-01702/4590228

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
Emanuel Gonçalves, Marco Sciacovelli, Ana S.H. Costa, Maxine Gia Binh Tran, Timothy Isaac Johnson, Daniel Machado, Christian Frezza, Julio Saez-Rodriguez
http://www.sciencedirect.com/science/article/pii/S1096717617303270

MITOCHONDRIAL PHOSPHOENOLPYRUVATE CARBOXYKINASE (PEPCK-M) REGULATES THE CELL METABOLISM OF PANCREATIC NEUROENDOCRINE TUMORS (PNET) AND DE-SENSITIZES PNET TO MTOR INHIBITORS
Pei-Yi Chu, Shih Sheng Jiang, Yan-Shen Shan, Wen-Chun Hung, Ming-Huang Chen, Hui-You Lin, Yu-Lin Chen,Hui-Jen Tsai,  and  Li-Tzong Chen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21665&path%5B%5D=68794

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Metabolic stress / sensing
——————————————–

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yanhui Xu, Wei Xu, Shi-Min Zhao
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30629-0

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
Xin Gu, Jose M. Orozco, Robert A. Saxton, Kendall J. Condon, Grace Y. Liu, Patrycja A. Krawczyk, Sonia M. Scaria, J. Wade Harper, Steven P. Gygi, David M. Sabatini
http://science.sciencemag.org/content/358/6364/813

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis
Rosa Martín-Pérez, Rosario Yerbes, Rocío Mora-Molina, Ana Cano-González, Joaquín Arribas, Massimiliano Mazzone, Abelardo López-Rivas and Carmen Palacios
http://oncotarget.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21458

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling
Alberto Bartolomé, Ana García-Aguilar, Shun-Ichiro Asaharad, Yoshiaki Kido, Carlos Guillén, Utpal B. Pajvani and Manuel Benito
http://mcb.asm.org/content/37/23/e00441-17.abstract?etoc

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade
Hui-wen Lue, Jennifer Podolak, Kevin Kolahi, Larry Cheng, Soumya Rao, Devin Garg, Chang-Hui Xue, Juha K. Rantala, Jeffrey W. Tyner, Kent L. Thornburg, Ann Martinez-Acevedo, Jen-Jane Liu, Christopher L. Amling, Charles Truillet, Sharon M. Louie, Kimberly E. Anderson, Michael J. Evans, Valerie B. O’Donnell, Daniel K. Nomura, Justin M. Drake, Anna Ritz and George V. Thomas
http://genesdev.cshlp.org/content/31/20/2067.abstract?etoc

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Hypoxia / hyperoxia
———————————-

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Samantha W. Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi, Thales Papagiannakopoulos, Andre L. Moreira, Sylvia Adams, David M. Sabatini, Kıvanç Birsoy & Richard Possemato
https://www.nature.com/articles/nature24637

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion
M Swayampakula, P C McDonald, M Vallejo, E Coyaud, S C Chafe, A Westerback, G Venkateswaran, J Shankar, G Gao, E M N Laurent, Y Lou, K L Bennewith, C T Supuran, I R Nabi, B Raught and S Dedhar
https://www.nature.com/articles/onc2017219

A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes
Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka and Hiroshi Harada
http://onlinelibrary.wiley.com/doi/10.1111/febs.14280/abstract

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells
Shalini Sethumadhavan, Murillo Silva, Phaethon Philbrook, Thao Nguyen, Stephen M. Hatfield, Akio Ohta, Michail V. Sitkovsky
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187314

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Juan Liu, Cen Zhang, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A. Khella, Michael L. Gatza, Dajing Xia, Jimin Gao, Eileen White, Bruce G. Haffty, Wenwei Hu & Zhaohui Feng
https://www.nature.com/articles/s41467-017-01947-w

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Miscellaneous
————————-

Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice
Jonathan M. Ploeger, Juan C. Manivel, Lauren N. Boatner and Douglas G. Mashek
http://cancerpreventionresearch.aacrjournals.org/content/10/11/660

Branched‐chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype
Lidia Santos Silva, Gernot Poschet, Yannic Nonnenmacher, Holger M Becker, Sean Sapcariu, Ann‐Christin Gaupel, Magdalena Schlotter, Yonghe Wu, Niclas Kneisel, Martina Seiffert, Rüdiger Hell, Karsten Hiller, Peter Lichter and Bernhard Radlwimmer
http://EMBOr.embopress.org/content/18/12/2172?etoc

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Benoit Bilanges, Samira Alliouachene, […] Bart Vanhaesebroeck
https://www.nature.com/articles/s41467-017-01969-4

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
Shuan Rao, Verena Sigl, Reiner Alois Wimmer, Maria Novatchkova, Alexander Jais, Gabriel Wagner, Stephan Handschuh, Iris Uribesalgo, Astrid Hagelkruys, Ivona Kozieradzki, Luigi Tortola, Roberto Nitsch, Shane J. Cronin, Michael Orthofer, Daniel Branstetter, Jude Canon, John Rossi, Manolo D’Arcangelo, Johan Botling, Patrick Micke, Linnea La Fleur, Karolina Edlund, Michael Bergqvist, Simon Ekman, Thomas Lendl, Helmut Popper, Hiroshi Takayanagi, Lukas Kenner, Fred R. Hirsch, William Dougall and Josef M. Penninger
http://genesdev.cshlp.org/content/31/20/2099.abstract?etoc

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Reviews
——————

Focus: Metabolism: MYC and tumor metabolism: chicken and egg
Francesca R Dejure and Martin Eilers
http://EMBOJ.embopress.org/content/36/23/3409?etoc

The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer
Robert G. Shulman, Douglas L. Rothman
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30193-0

Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis
Eldad Zacksenhaus, Mariusz Shrestha, Jeff C. Liu, Ioulia Vorobieva, Philip E.D. Chung, YoungJun Ju, Uri Nir, Zhe Jiang
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30176-0

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells
Inge M.N. Wortel, Laurens T. van der Meer, Michael S. Kilberg, Frank N. van Leeuwen
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(17)30100-5

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Hamoud Al-Khallaf
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-017-0165-3

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology
Hitoshi Shimano & Ryuichiro Sato
https://www.nature.com/articles/nrendo.2017.91

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells
Inge M.N. Wortel , Laurens T. van der Meer , Michael S. Kilberg, Frank N. van Leeuwen
http://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(17)30100-5

Understanding Mitochondrial Polymorphisms in Cancer
Karen M. Bussard and Linda D. Siracusa
http://cancerres.aacrjournals.org/content/77/22/6051

METABOLOMIC MAPPING OF CANCER STEM CELLS FOR REDUCING AND EXPLOITING TUMOR HETEROGENEITY
Elisabet Cuyàs, Sara Verdura, Salvador Fernández-Arroyo, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Jorge Joven,  and  Javier A. Menendez
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21834&path%5B%5D=69257

ATM Modulation of Carbon Metabolism in Cancer
Erika S. Dahl and Katherine M. Aird
https://www.frontiersin.org/articles/10.3389/fonc.2017.00291/abstract

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
Luisa Iommarini, Anna Maria Porcelli, Giuseppe Gasparre and Ivana Kurelac
https://www.frontiersin.org/articles/10.3389/fonc.2017.00286/full

E2F1, a Novel Regulator of Metabolism
Pierre-Damien Denechaud, Lluis Fajas and Albert Giralt
https://www.frontiersin.org/articles/10.3389/fendo.2017.00311/full

Mitochondria, Bioenergetics and Apoptosis in Cancer
Peter J. Burke
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30200-5

Mitochondrial Transfer in the Leukemia Microenvironment
Emmanuel Griessinger, Ruxanda Moschoi, Giulia Biondani, Jean-François Peyron
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30197-8

Drosophila as a Model to Study the Link between Metabolism and Cancer
Héctor Herranz  and Stephen M. Cohen
http://www.mdpi.com/2221-3759/5/4/15

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Comments / Previews
————————————–

Resistance Is Futile: Targeting Mitochondrial Energetics and Metabolism to Overcome Drug Resistance in Cancer Treatment
Claudie Bosc, Mary A. Selak, Jean-Emmanuel Sarry
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30627-7

AMPK: keeping the (power)house in order?
Claire Thornton
http://www.neuronalsignaling.org/content/1/2/NS20160020

The folate cycle is a new metabolic weakness of cancer
Derek Lee & Carmen Chak-Lui Wong
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1327004

Sugar industry sponsorship of germ-free rodent studies linking sucrose to hyperlipidemia and cancer: An historical analysis of internal documents
Cristin E. Kearns, Dorie Apollonio, Stanton A. Glantz
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003460

Metabolism: More lactate, please
https://www.nature.com/articles/nrc.2017.101

Serving cancer its last meal
http://stm.sciencemag.org/content/9/415/eaaq1233.full

Fatty-Acid Catabolism Promotes T-cell Revitalization in Melanoma
http://cancerdiscovery.aacrjournals.org/content/7/11/1213.2

MetaboList – October 2017

———————————————————–
Lactate metabolism and transporters
———————————————————–

Lactate Metabolism in Human Lung Tumors
Brandon Faubert, Kevin Y. Li, Ling Cai, Christopher T. Hensley, Jiyeon Kim, Lauren G. Zacharias, Chendong Yang, Quyen N. Do, Sarah Doucette, Daniel Burguete, Hong Li, Giselle Huet, Qing Yuan, Trevor Wigal, Yasmeen Butt, Min Ni, Jose Torrealba, Dwight Oliver, Robert E. Lenkinski, Craig R. Malloy, Jason W. Wachsmann, Jamey D. Young, Kemp Kernstine, Ralph J. DeBerardinis
http://www.cell.com/cell/fulltext/S0092-8674(17)31068-1

Glucose feeds the TCA cycle via circulating lactate
Sheng Hui, Jonathan M. Ghergurovich, Raphael J. Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A. Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White & Joshua D. Rabinowitz
http://www.nature.com/nature/journal/v551/n7678/full/nature24057.html

Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter
Valéry L. Payen, Myriam Y. Hsu, Kristin S. Rädecke, Elisabeth Wyart, Thibaut Vazeille, Caroline Bouzin, Paolo E. Porporato and Pierre Sonveaux
http://cancerres.aacrjournals.org/content/77/20/5591

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness
Young-Kyoung Lee, Jin J Lim, Un-woo Jeoun, Seongki Min, Eun-beom Lee, So Mee Kwon, Changhan Lee and Gyesoon Yoon
http://www.jbc.org/content/early/2017/10/04/jbc.M117.809012.abstract

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Glucose metabolism
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Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
Ken Peeters, Frederik Van Leemputte, Baptiste Fischer, Beatriz M. Bonini, Hector Quezada, Maksym Tsytlonok, Dorien Haesen, Ward Vanthienen, Nuno Bernardes, Carmen Bravo Gonzalez-Blas, Veerle Janssens, Peter Tompa, Wim Versées & Johan M. Thevelein
https://www.nature.com/articles/s41467-017-01019-z

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Fabao Liu,Fengfei Ma,Yuyuan Wang,Ling Hao,Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M. Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li& Wei Xu
http://www.nature.com/ncb/journal/v19/n11/full/ncb3630.html

DISRUPTING GLUCOSE-6-PHOSPHATE ISOMERASE FULLY SUPPRESSES THE “WARBURG EFFECT” AND ACTIVATES OXPHOS WITH MINIMAL IMPACT ON TUMOR GROWTH EXCEPT IN HYPOXIA
Monique Cunha de Padua, Giulia Delodi, Milica Vučetić, Jérôme Durivault, Valérie Vial, Pascale Bayer, Guilhermina Rodrigues Noleto, Nathalie M. Mazure, Maša Ždralević,  and  Jacques Pouysségur
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21007&path%5B%5D=66903

Regulation of Glycolytic Metabolism by Autophagy in Liver Cancer Involves Selective Autophagic Degradation of HK2 (hexokinase 2)
Lin Jiao, Hai-Liang Zhang, Dan-Dan Li, Ke-Li Yang, Jun Tang, Xuan Li, Jiao Ji, Yan Yu, Rui-Yan Wu, Senthilkumar Ravichandran, Jian-Jun Liu, Gong-Kan Feng, Min-Shan Chen, Yi-Xin Zeng, Rong Deng & Xiao-Feng Zhu
http://www.tandfonline.com/doi/abs/10.1080/15548627.2017.1381804

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress
Shady Saad,Gea Cereghetti,Yuehan Feng,Paola Picotti,Matthias Peter& Reinhard Dechant
http://www.nature.com/ncb/journal/v19/n10/full/ncb3600.html

Srebp-controlled glucose metabolism is essential for NK cell functional responses
Nadine Assmann, Katie L O’Brien, Raymond P Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M Loftus, Paul Heinrich, Peter J Oefner, Lydia Lynch, Clair M Gardiner, Katja Dettmer & David K Finlay
https://www.nature.com/articles/ni.3838

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells
Ana Rodríguez-García, Paula Samsó, Pere Fontova, Helga Simon-Molas, Anna Manzano, Esther Castaño, Jose Luis Rosa, Ubaldo Martinez-Outshoorn, Francesc Ventura, Àurea Navarro-Sabaté and Ramon Bartrons
http://onlinelibrary.wiley.com/doi/10.1111/febs.14201/abstract?campaign=woletoc

Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth
[yeast]
Zheng Kuang, Sudarshan Pinglay, Hongkai Ji and Jef D Boeke
https://elifesciences.org/articles/29938

Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect
Smriti Singh, Sathiya Pandi Narayanan, Kajal Biswas, Amit Gupta, Neha Ahuja, Sandhya Yadav, Rajendra Kumar Panday, Atul Samaiya, Shyam K. Sharan, and Sanjeev Shukla
http://www.pnas.org/content/114/43/11440.abstract.html?etoc

PKM2 ACTIVATION SENSITIZES CANCER CELLS TO GROWTH INHIBITION BY 2-DEOXY-D-GLUCOSE
Sui Seng Tee, Jae Mo Park, Ralph E. Hurd, Kyle R. Brimacombe, Matthew B. Boxer, Tarik F. Massoud, Brian K. Rutt,  and  Daniel M. Spielman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19630&path[]=62716

——————————————————–
Amino acids / proteins / Glutathione
——————————————————–

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Gregory A. Wyant, Monther Abu-Remaileh, Rachel L. Wolfson, Walter W. Chen, Elizaveta Freinkman, Laura V. Danai, Matthew G. Vander Heiden, David M. Sabatini
http://www.cell.com/cell/fulltext/S0092-8674(17)31140-6

Critical role for PI3-kinase in regulating the use of proteins as an amino acid source
Wilhelm Palm, Jingwen Araki, Bryan King, Raymond G. DeMatteo, and Craig B. Thompson
http://www.pnas.org/content/114/41/E8628.abstract.html?etoc

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K. Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G. Manfredi, Zemer Gitai, Hahn Kim, and Joshua D. Rabinowitz
http://www.pnas.org/content/114/43/11404.abstract.html?etoc

TAp73 is a marker of glutamine addiction in medulloblastoma
Maria Victoria Niklison-Chirou, Ida Erngren, Mikael Engskog, Jakob Haglöf, Daniel Picard, Marc Remke, Phelim Hugh Redmond McPolin, Matthew Selby, Daniel Williamson, Steven C. Clifford, David Michod, Michalis Hadjiandreou, Torbjörn Arvidsson, Curt Pettersson, Gerry Melino and Silvia Marino
http://genesdev.cshlp.org/content/31/17/1738.abstract?etoc

Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in triple negative breast cancer
Alexander Beatty, Lauren S. Fink, Tanu Singh, Alexander Strigun, Erik Peter, Christina M. Ferrer, Emmanuelle Nicolas, Kathy Q. Cai, Timothy P. Moran, Mauricio J. Reginato, Ulrike Rennefahrt and Jeffrey R. Peterson
http://mct.aacrjournals.org/content/early/2017/10/11/1535-7163.MCT-17-0407.long

AUTOPHAGY SUPPRESSION POTENTIATES THE ANTI-GLIOBLASTOMA EFFECT OF ASPARAGINASE IN VITRO AND IN VIVO
Qicheng Chen, Li Ye, Jiajun Fan, Xuyao Zhang, Huan Wang, Siyang Liao, Ping Song, Ziyu Wang, Shaofei Wang, Yubin Li, Jingyun Luan, Yichen Wang, Wei Chen, Wenjing Zai, Ping Yang, Zhonglian Cao,  and  Dianwen Ju
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19409&path[]=62078

Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia
S M Kang, J L Rosales, V Meier-Stephenson, S Kim, K Y Lee and A Narendran
http://www.nature.com/onc/journal/v36/n42/abs/onc2017211a.html

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Mitochondria and ROS
———————————————-

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Elodie M Kuntz, Pablo Baquero, Alison M Michie, Karen Dunn,Saverio Tardito, Tessa L Holyoake, G Vignir Helgason & Eyal Gottlieb
http://www.nature.com/nm/journal/v23/n10/full/nm.4399.html

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive D’Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R. Griffiths, Christian Frezza
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31412-2

Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue
Allison J. Richard, Hardy Hang and Jacqueline M. Stephens
http://www.jbc.org/content/early/2017/10/05/jbc.M117.811794.abstract

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission
So Hee Ko, Gee Euhn Choi, Ji Young Oh, Hyun Jik Lee, Jun Sung Kim, Chang Woo Chae, Diana Choi & Ho Jae Han
https://www.nature.com/articles/s41598-017-12692-x

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
Karthigayan Shanmugasundaram, Bijaya K. Nayak, William E. Friedrichs, Dharam Kaushik, Ronald Rodriguez & Karen Block
https://www.nature.com/articles/s41467-017-01106-1

A CRISPR screen identifies a pathway required for paraquat-induced cell death
Colleen R Reczek, Kivanc¸ Birsoy, Hyewon Kong, Inmaculada Martínez-Reyes, Tim Wang,Peng Gao, David M Sabatini& Navdeep S Chandel
https://www.nature.com/articles/nchembio.2499

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
Christopher R. Marlein, Lyubov Zaitseva, Rachel E. Piddock, Stephen D. Robinson, Dylan R. Edwards, Manar S. Shafat, Zhigang Zhou, Matthew Lawes, Kristian M. Bowles and Stuart A. Rushworth
http://bloodjournal.org/content/130/14/1649.abstract?etoc

A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
Yoav Elkis, Moshe Cohen, Etai Yaffe, Shirly Satmary-Tusk, Tal Feldman, Elad Hikri, Abraham Nyska, Ariel Feiglin, Yanay Ofran, Sally Shpungin & Uri Nir
https://www.nature.com/articles/s41467-017-00832-w

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Nucleotide metabolism
—————————————

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Alexander J. Valvezan, MarcTurner, Amine Belaid, Hilaire C. Lam, Spencer K. Miller, Molly C.McNamara, Christian Baglini, Benjamin E. Housden, Norbert Perrimon, David J.Kwiatkowski, John M.Asara, Elizabeth P.Henske, Brendan D. Manning
http://www.cell.com/cancer-cell/abstract/S1535-6108(17)30417-8

Molecular features that predict the response to antimetabolite chemotherapies
Mahya Mehrmohamadi, Seong Ho Jeong and Jason W. Locasale
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0170-3

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Fatty acids / cholesterol
————————————————

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Saber Tadros, Surendra K. Shukla, Ryan J. King, Venugopal Gunda, Enza Vernucci, Jaime Abrego, Nina V. Chaika, Fang Yu, Audrey J. Lazenby, Lyudmyla Berim, Jean Grem, Aaron R. Sasson and Pankaj K. Singh
http://cancerres.aacrjournals.org/content/77/20/5503

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Maud Voisin, Philippe de Medina, Arnaud Mallinger, Florence Dalenc, Emilie Huc-Claustre, Julie Leignadier, Nizar Serhan, Régis Soules, Grégory Ségala, Aurélie Mougel, Emmanuel Noguer, Loubna Mhamdi, Elodie Bacquié, Luigi Iuliano, Chiara Zerbinati, Magali Lacroix-Triki, Léonor Chaltiel, Thomas Filleron, Vincent Cavaillès, Talal Al Saati, Philippe Rochaix, Raphaelle Duprez-Paumier, Camille Franchet, Laetitia Ligat, Fréderic Lopez, Michel Record, Marc Poirot, and Sandrine Silvente-Poirot
http://www.pnas.org/content/114/44/E9346.abstract.html?etoc

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
Amy E. Baek, Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, Hannah B. McDowell, J. Will Thompson, Laura G. Dubois, Patrick M. Sullivan, Jongsook K. Kemper, Michael D. Gunn, Donald P. McDonnell & Erik R. Nelson
https://www.nature.com/articles/s41467-017-00910-z

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Nutrient sensing / starvation
————————————————

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31461-4

Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression.
Atsuhiro Adachi, Michiko Koizumi and Yoshinori Ohsumi
http://www.jbc.org/content/early/2017/10/17/jbc.M117.817510.abstract

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
Takeo Goji, Kazuhiko Takahara, Manabu Negishi and Hironori Katoh
http://www.jbc.org/content/early/2017/10/16/jbc.M117.814392.abstract

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
Zhen-Dong Xiao, Leng Han, Hyemin Lee, Li Zhuang, Yilei Zhang, Joelle Baddour, Deepak Nagrath, Christopher G. Wood, Jian Gu, Xifeng Wu, Han Liang & Boyi Gan
https://www.nature.com/articles/s41467-017-00902-z

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Hypoxia, HIFs
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Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation
Lauren K. Brady, Hejia Wang, Caleb M. Radens, Yue Bi, Milan Radovich, Amit Maity, Cristina Ivan, Mircea Ivan, Yoseph Barash, Constantinos Koumenis
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002623

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Kate Vandyke, Mara N. Zeissig, Duncan R. Hewett, Sally K. Martin, Krzysztof M. Mrozik, Chee Man Cheong, Peter Diamond, L. BikTo, Stan Gronthos, Daniel J. Peet, Peter I. Croucher and Andrew C.W. Zannettino
http://cancerres.aacrjournals.org/content/77/20/5452

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Angiogenesis
————————-

Adrenergic nerves activate an angio-metabolic switch in prostate cancer
Ali H. Zahalka, Anna Arnal-Estapé, Maria Maryanovich, Fumio Nakahara, Cristian D. Cruz, Lydia W. S. Finley, Paul S. Frenette
http://science.sciencemag.org/content/358/6361/321

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
D Chen, Z Fan, M Rauh, M Buchfelder, I Y Eyupoglu and N Savaskan
http://www.nature.com/onc/journal/v36/n40/abs/onc2017146a.html

————
Tor
————

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
Mariana E. G. de Araujo , Andreas Naschberger, Barbara G. Fürnrohr, Taras Stasyk, Theresia Dunzendorfer-Matt, Stefan Lechner, Stefan Welti, Leopold Kremser, Giridhar Shivalingaiah, Martin Offterdinger, Herbert H. Lindner, Lukas A. Huber, Klaus Scheffzek
http://science.sciencemag.org/content/358/6361/377

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
Manoël Prouteau, Ambroise Desfosses, Christian Sieben, Clélia Bourgoint, Nour Lydia Mozaffari, Davide Demurtas, Alok K. Mitra, Paul Guichard, Suliana Manley & Robbie Loewith
http://www.nature.com/nature/journal/vaop/ncurrent/full

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Jong Hyun Kim, Chulho Lee, […], Sunghoon Kim
https://www.nature.com/articles/s41467-017-00785-0

—————–
AMPK
—————–

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Isabel C. Lopez-Mejia, Sylviane Lagarrigue, Albert Giralt, Laia Martinez-Carreres, Nadège Zanou, Pierre-Damien Denechaud, Judit Castillo-Armengol, Carine Chavey, Meritxell Orpinell, Brigitte Delacuisine, Anita Nasrallah, Caterina Collodet, Lianjun Zhang, Benoît Viollet, D. Grahame Hardie, Lluis Fajas
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30712-8

AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β
Akihiro Nakanishi, Naoya Hatano, Yuya Fujiwara, Arian Bin Shari, Shota Takabatake, Hiroki Akano, Naoki Kanayama, Masaki Magari, Naohito Nozaki and Hiroshi Tokumitsu
http://www.jbc.org/content/early/2017/10/03/jbc.M117.805085.abstract

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Miscellaneous
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Mitochondrial Priming by CD28
Ramon I. Klein Geltink, David O’Sullivan, Mauro Corrado, Anna Bremser, Michael D. Buck, Joerg M. Buescher, Elke Firat, Xuekai Zhu, Gabriele Niedermann, George Caputa, Beth Kelly, Ursula Warthorst, Anne Rensing-Ehl, Ryan L. Kyle, Lana Vandersarren, Jonathan D. Curtis, Annette E. Patterson, Simon Lawless, Katarzyna Grzes, Jing Qiu, David E. Sanin, Oliver Kretz, Tobias B. Huber, Sophie Janssens, Bart N. Lambrecht, Angelika S. Rambold, Edward J. Pearce, Erika L. Pearce
http://www.cell.com/cell/fulltext/S0092-8674(17)30943-1

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll & Markus D. Siegelin
https://www.nature.com/articles/s41467-017-00984-9

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties
Atreyi Dasgupta, Matteo Trucco, Nino Rainusso, Ronald J. Bernardi, Ryan Shuck, Lyazat Kurenbekova, David M. Loeb and Jason T. Yustein
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20467

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Reviews
——————–

The impact of cellular metabolism on chromatin dynamics and epigenetics
Michael A. Reid, Ziwei Dai and Jason W. Locasale
http://www.nature.com/ncb/journal/v19/n11/full/ncb3629.html

AMPK: guardian of metabolism and mitochondrial homeostasis
Sébastien Herzig & Reuben J. Shaw
https://www.nature.com/nrm/journal/vaop/ncurrent/full/nrm.2017.95.html

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer
Marco Sciacovelli and Christian Frezza
http://onlinelibrary.wiley.com/doi/10.1111/febs.14090/abstract

Metabolic Interactions in the Tumor Microenvironment
Costas A. Lyssiotis, Alec C. Kimmelman
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2

Emerging Roles for the Lysosome in Lipid Metabolism
Ashley M. Thelen, Roberto Zoncu
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30124-1

Editorial: Cancer Metabolism: Molecular Targeting and Implications for Therapy
Shanmugasundaram Ganapathy-Kanniappan
https://www.frontiersin.org/articles/10.3389/fonc.2017.00232/full

The Linkage between Breast Cancer, Hypoxia, and Adipose Tissue
Linda Rausch, Nikolaus Netzer, Josef Hoegel, and Stephan Pramsohler
https://www.frontiersin.org/articles/10.3389/fonc.2017.00211/full

Oxygen availability and metabolic reprogramming in cancer
Hong Xie and M. Celeste Simon
http://www.jbc.org/content/292/41/16825.abstract

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
Takafumi Suzuki and Masayuki Yamamoto
http://www.jbc.org/content/292/41/16817.abstract.html

Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer
Cristina Aguirre-Portolés, Lara P. Fernández and Ana Ramírez de Molina
http://www.mdpi.com/2072-6643/9/10/1076

Fumarase Deficiency: A Safe and Potentially Disease Modifying Effect of High Fat/Low Carbohydrate Diet
B. Ryder, F. Moore, A. Mitchell, S. Thompson, J. Christodoulou, S. Balasubramaniam
https://link.springer.com/chapter/10.1007/8904_2017_65

Lipid metabolism fattens up hedgehog signaling
Robert Blassberg and John Jacob
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0442-y

———————————-
Previews / other
———————————-

Twenty-five years of mTOR: Uncovering the link from nutrients to growth
David M. Sabatini
http://www.pnas.org/content/early/2017/10/17/1716173114.abstract

Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal
Marco Napoli and Elsa R. Flores
http://genesdev.cshlp.org/content/31/17/1715.abstract?etoc

Mitochondria on the move: BMSCs fuel AML energy
Rosa Lapalombella
http://bloodjournal.org/content/130/14/1603?etoc

Lessons from Yeast on How to Avoid Stress Eating
Jean A. Smith, Amy S. Gladfelter
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30767-0

Mitophagy, metabolism, and cell fate
Lorena Esteban-Martínez, Elena Sierra-Filardi & Patricia Boya
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1353854

Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control
Nahum Sonenberg
http://www.pnas.org/content/114/44/11564.extract.html?etoc

MetaboList – September 2017

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Glucose metabolism
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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
Maria V. Liberti, Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O. Johnson, Neel S. Madhukar, Alexander A. Shestov, Iok I. Christine Chio, Olivier Elemento, Jeffrey C. Rathmell, Frank C. Schroeder, Donald P. McDonnell, Jason W. Locasale
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30502-8

LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism
Xin Zheng, Han Han, Guang‐Ping Liu, Yan‐Xiu Ma, Ruo‐Lang Pan, Ling‐Jie Sang, Rui‐Hua Li, Luo‐Jia Yang, Jeffrey R Marks, Wenqi Wang, Aifu Lin
http://emboj.embopress.org/content/early/2017/09/28/embj.201797609

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade
Lena-Christin Conradi, Aleksandra Brajic, Anna Rita Cantelmo, Ann Bouché, Joanna Kalucka, Andreas Pircher, Ulrike Brüning, Laure-Anne Teuwen, Stefan Vinckier, Bart Ghesquière, Mieke Dewerchin, Peter Carmeliet
https://link.springer.com/article/10.1007/s10456-017-9573-6

An engineered photoswitchable mammalian pyruvate kinase
Stefanie Gehrig, Jamie A. Macpherson, Paul C. Driscoll, Alastair Symon, Stephen R. Martin, James I. MacRae, Jens Kleinjung, Franca Fraternali and Dimitrios Anastasiou
http://onlinelibrary.wiley.com/doi/10.1111/febs.14175/abstract

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand
Tamir Epstein, Robert A. Gatenby, Joel S. Brown
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185085

SLC2A2 (GLUT2) AS A NOVEL PROGNOSTIC FACTOR FOR HEPATOCELLULAR CARCINOMA
Yun Hak Kim, Dae Cheon Jeong, Kyoungjune Pak, Myoung-Eun Han, Ji-Young Kim, Liu Liangwen, Hyun Jin Kim,Tae Woo Kim, Tae Hwa Kim, Dong Woo Hyun, and Sae-Ock Oh
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20266&path%5B%5D=64619

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Amino acid metabolism or acquired dependency
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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Volkan I Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden and Thales Papagiannakopoulos
https://elifesciences.org/articles/28083

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Rodrigo Romero, Volkan I Sayin, Shawn M Davidson, Matthew R Bauer, Simranjit X Singh, Sarah E LeBoeuf, Triantafyllia R Karakousi, Donald C Ellis, Arjun Bhutkar, Francisco J Sánchez-Rivera, Lakshmipriya Subbaraj, Britney Martinez, Roderick T Bronson, Justin R Prigge, Edward E Schmidt, Craig J Thomas, Chandra Goparaju, Angela Davies, Igor Dolgalev, Adriana Heguy, Viola Allaj, John T Poirier, Andre L Moreira, Charles M Rudin, Harvey I Pass, Matthew G Vander Heiden, Tyler Jacks & Thales Papagiannakopoulos
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4407.html

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect
Chiara Damiani, Riccardo Colombo, Daniela Gaglio, Fabrizia Mastroianni, Dario Pescini, Hans Victor Westerhoff, Giancarlo Mauri, Marco Vanoni, Lilia Alberghina
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005758

Bortezomib resistance in multiple myeloma is associated with increased serine synthesis
Esther A. Zaal, Wei Wu, Gerrit Jansen, Sonja Zweegman, Jacqueline Cloos and Celia R. Berkers
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0169-9

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition
Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Hong Cheng, Jack Pollard, Christopher Winter, Victoria Richon, Carlos Garcia-Escheverria, Francisco Adrian, Dmitri Wiederschain, Lakshmi Srinivasan
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185092

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Lipids
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Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer
Ariadna Giró-Perafita, Ariadna Sarrats, Ferran Pérez-Bueno, Glòria Oliveras, Maria Buxó, Joan Brunet, Gemma Viñas and Teresa Puig Miquel
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=4b82f887a0&e=923b339f12

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Mitochondria
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MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Kyung-min Lee, Jennifer M. Giltnane, Justin M. Balko, Luis J. Schwarz, Angel L. Guerrero-Zotano, Katherine E. Hutchinson, Mellissa J. Nixon, Mónica V. Estrada, Violeta Sánchez, Melinda E. Sanders, Taekyu Lee, Henry Gómez, Ana Lluch, J. Alejandro Pérez-Fidalgo, Melissa Magdalene Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Stephen W. Fesik, Carlos L. Arteaga
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30560-0

Architecture of Human Mitochondrial Respiratory Megacomplex I2 III2 IV2
Runyu Guo, Shuai Zong, Meng Wu, Jinke Gu, Maojun Yang
http://www.cell.com/cell/fulltext/S0092-8674(17)30887-5

Comprehensive mathematical model of oxidative phosphorylation valid for physiological and pathological conditions
Margit Heiske, Thierry Letellier, Edda Klipp
http://onlinelibrary.wiley.com/doi/10.1111/febs.14151/full

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
Elodie Villa, Emma Proïcs, Camila Rubio-Patiño, Sandrine Obba, Barbara Zunino, Jozef P. Bossowski, Romain M. Rozier, Johanna Chiche, Laura Mondragón, Joel S. Riley, Sandrine Marchetti, Els Verhoeyen, Stephen W.G. Tait, Jean-Ehrland Ricci
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31229-9

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Nucleotides
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Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
Kiyotoshi Satoh, Shinichi Yachida, Masahiro Sugimoto, Minoru Oshima, Toshitaka Nakagawa, Shintaro Akamoto, Sho Tabata, Kaori Saitoh, Keiko Kato, Saya Sato, Kaori Igarashi, Yumi Aizawa, Rie Kajino-Sakamoto, Yasushi Kojima, Teruaki Fujishita, Ayame Enomoto, Akiyoshi Hirayama, Takamasa Ishikawa, Makoto Mark Taketo, Yoshio Kushida, Reiji Haba, Keiichi Okano, Masaru Tomita, Yasuyuki Suzuki, Shinji Fukuda, Masahiro Aoki, and Tomoyoshi Soga
http://pnas.org/content/114/37/E7697.abstract.html?etoc

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism
Iñigo Apaolaza, Edurne San José-Eneriz, Luis Tobalina, Estíbaliz Miranda, Leire Garate, Xabier Agirre, Felipe Prósper & Francisco J. Planes
[Ribonucleotide reductase in multiple myeloma]
https://www.nature.com/articles/s41467-017-00555-y

Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis
Hsi-Wen Yeh, Szu-Shuo Lee, Chieh-Yu Chang, Chun-Mei Hu and Yuh-Shan Jou
http://impactjournals.us9.list-manage1.com/track/click?u=133779c099e52b6fa9d4dec2e&id=609b9c4ccf&e=923b339f12

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Hypoxia
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Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Jane Cui, Robin Kit-Ho Lai, Lynna Lan Li, Hui-Yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng & Carmen Chak-Lui Wong
https://www.nature.com/articles/s41467-017-00530-7

Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia
Dae Wui Yoon, Daeho So, Sra Min, Jiyoung Kim1, Mingyu Lee, Roza Khalmuratova1, Chung-Hyun Cho, Jong-Wan Park and Hyun-Woo Shin
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=504ebfc61a&e=923b339f12

Lactate stimulates CA IX expression in normoxic cancer cells
Elena Panisova, Martin Kery, Olga Sedlakova, Lucie Brisson, Michaela Debreova, Martina Sboarina, Pierre Sonveaux, Silvia Pastorekova and Eliska Svastova
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=12b16e857e&e=923b339f12

Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function
Yael Gropper, Tali Feferman, Tali Shalit, Tomer-Meir Salame, Ziv Porat, Guy Shakhar
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31213-5

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Starvation, mTOR
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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
Michel Nofal, Kevin Zhang, Seunghun Han, Joshua D. Rabinowitz
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30608-1

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu, Shi-Min Zhao & Wei Xu
https://www.nature.com/articles/s41467-017-00489-5

Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus
Joseph W. Briggs ,Ling Ren, Kristi R. Chakrabarti, Yien Che Tsai, Allan M. Weissman, Ryan J. Hansen, Daniel L. Gustafson, Yousuf A. Khan, Jonathan D. Dinman, Chand Khanna
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185089

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AMPK
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AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species
Rebecca C. Rabinovitch, Bozena Samborska, Brandon Faubert, Eric H. Ma, Simon-Pierre Gravel, Sylvia Andrzejewski, Thomas C. Raissi, Arnim Pause, Julie St.-Pierre, Russell G. Jones
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31301-3

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp & Jonathan S. Oakhill
https://www.nature.com/articles/s41467-017-00628-y

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
Eijiro Yamada, Shuichi Okada, Claire C. Bastie2, Manu Vatish4, Yasuyo Nakajima1, Ryo Shibusawa1, Atsushi Ozawa1, Jeffrey E. Pessin and Masanobu Yamada
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=11916&path%5B%5D=37725

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Metformin
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Metformin partially reverses the carboplatin-resistance in NSCLC by inhibiting glucose metabolism
Yong Liu, Chunxi He and Xianping Huang
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=28317ddf66&e=923b339f12

METFORMIN REQUIRES 4E-BPS TO INDUCE APOPTOSIS AND REPRESS TRANSLATION OF MCL-1 IN HEPATOCELLULAR CARCINOMA CELLS
Mamatha Bhat, Akiko Yanagiya, Tyson Graber, Nataliya Razumilava, Steve Bronk, Domenick Zammit, Yunhao Zhao, Chadi Zakaria, Peter Metrakos, Michael Pollak, Nahum Sonenberg, Gregory Gores, Maritza Jaramillo,Masahiro Morita, and Tommy Alain
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10671&path%5B%5D=33785

METFORMIN USE AND SURVIVAL OUTCOMES IN ENDOMETRIAL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS
Weimin Xie, Tianjia Li, Jing Yang, Mengmeng Shang, Ying Xiao, Qian Li, and Jiaxin Yang
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20388&path%5B%5D=64983

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Miscellaneous
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A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress
[free fatty acids]
Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, Roger J. Davis
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31132-4

Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages
Pengfei Sun, Huihui Wang, Zhiyong He, Xiangyuan Chen, Qichao Wu, Wankun Chen, Zhirong Sun, Meilin Weng, Minmin Zhu, Duan Ma and Changhong Miao
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=893e718d86&e=923b339f12

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1
Tali Mazor, Charles Chesnelong, Aleksandr Pankov, Llewellyn E. Jalbert, Chibo Hong, Josie Hayes, Ivan V. Smirnov, Roxanne Marshall, Camila F. Souza, Yaoqing Shen, Pavithra Viswanath, Houtan Noushmehr, Sabrina M. Ronen, Steven J. M. Jones, Marco A. Marra, J. Gregory Cairncross, Arie Perry, Sarah J. Nelson, Susan M. Chang, Andrew W. Bollen, Annette M. Molinaro, Henrik Bengtsson, Adam B. Olshen, Samuel Weiss, Joanna J. Phillips, H. Artee Luchman, and Joseph F. Costello
http://www.pnas.org/content/114/40/10743.abstract.html?etoc

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Reviews
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Targeting Metabolism for Cancer Therapy
Alba Luengo, Dan Y. Gui, Matthew G. Vander Heiden
http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30326-4

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease
John Blenis
http://www.cell.com/cell/fulltext/S0092-8674(17)30944-3

Game of TOR – The Target of Rapamycin Rules Four Kingdoms.
Manning BD.
http://www.nejm.org/doi/full/10.1056/NEJMcibr1709384

Mitochondrial Metabolism: Yin and Yang for Tumor Progression
Lorea Valcarcel-Jimenez, Edoardo Gaude, Veronica Torrano, Christian Frezza, Arkaitz Carracedo
http://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760%2817%2930087-5

Breaking fat: The regulation and mechanisms of lipophagy
Ryan J. Schulze, Aishwarya Sathyanarayan, Douglas G. Mashek
http://www.sciencedirect.com/science/article/pii/S1388198117301129?dgcid=raven_sd_via_email

Metabolism shapes the tumor microenvironment
Miguel Reina-Campos, Jorge Moscat, Maria Diaz-Meco
http://www.sciencedirect.com/science/article/pii/S0955067416301636

Integration of hypoxic HIF-α signaling in blood cancers
L Schito, S Rey and M Konopleva
http://www.nature.com/onc/journal/v36/n38/abs/onc2017119a.html

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling
Laurence M. Gagné, Karine Boulay, Ivan Topisirovic, Marc-Étienne Huot, Frédérick A. Mallette
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30101-0

Tumour acidosis: from the passenger to the driver’s seat
Cyril Corbet, Olivier Feron
http://www.nature.com/nrc/journal/v17/n10/abs/nrc.2017.77.html?lang=en

Exercise-dependent regulation of the tumour microenvironment
Graeme J. Koelwyn, Daniela F. Quail, Xiang Zhang, Richard M. White & Lee W. Jones
http://www.nature.com/nrc/journal/v17/n10/full/nrc.2017.78.html?WT.mc_id=FBK_NatureReviews&foxtrotcallback=true

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors
Steven S. Doerstling, Ciara H. O’Flanagan and Stephen D. Hursting
https://www.frontiersin.org/articles/10.3389/fonc.2017.00216/full

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response
Davide D’Amico, Vincenzo Sorrentino, Johan Auwerx
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30090-7

Focus: Metabolism: Modulating NAD^+ metabolism, from bench to bedside
Elena Katsyuba and Johan Auwerx
http://EMBOJ.embopress.org/content/36/18/2670?etoc

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Comments / Other
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In the news: The Lasker goes to Michael Hall
http://www.nature.com/nrm/journal/v18/n10/full/nrm.2017.97.html

An Amazing Turn of Events
Michael N. Hall
http://www.cell.com/cell/fulltext/S0092-8674(17)30946-7

The Ire1 Twist that Links Proteostatic with Lipostatic Control of the Endoplasmic Reticulum
Tomás Aragón, Eelco van Anken
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30147-2

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs
Will Bailis, Justin A. Shyer, Michael Chiorazzi, Richard A. Flavell
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30358-6

PON2 Promotes Glucose Uptake to Support PDAC Growth and Metastasis
http://cancerdiscovery.aacrjournals.org/content/7/10/1058.2

MetaboList – August 2017

———————-
Reviews
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The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
Rachel L. Wolfson, David M. Sabatini
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30422-9

Serine and Functional Metabolites in Cancer
Alice C. Newman, Oliver D.K. Maddocks
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30075-2

Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?
Sarah-Maria Fendt
http://journal.frontiersin.org/article/10.3389/fendo.2017.00150/full

Oxygen availability and metabolic reprogramming in cancer
Hong Xie and M Celeste Simon
http://www.jbc.org/content/early/2017/08/24/jbc.R117.799973.abstract

Succinate: An initiator in tumorigenesis and progression
Ting Zhao, Xianmin Mu and Qiang You
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=17734&path%5B%5D=56800

EFFECTS OF METFORMIN ON SURVIVAL OUTCOMES OF PANCREATIC CANCER: A META-ANALYSIS
Yi-wei Dong, Yan-qiang Shi, Li-wen He, Xi-yu Cui, and Pei-zhu Su
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18233&path%5B%5D=58448

Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell Fate
Maria Livia Sassano, Alexander R. van Vliet and Patrizia Agostinis
http://journal.frontiersin.org/article/10.3389/fonc.2017.00174/full

Involvement of the Warburg effect in non-tumor diseases processes
Zhe Chen, Meiqing Liu, Lanfang Li and Linxi Chen
http://onlinelibrary.wiley.com/doi/10.1002/jcp.25998/full/

NAD+ Deficits in Age-Related Diseases and Cancer
Amanda Garrido, Nabil Djouder
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30105-X

Targeting autophagy in cancer
Jean M. Mulcahy Levy, Christina G. Towers & Andrew Thorburn
http://www.nature.com/nrc/journal/v17/n9/abs/nrc.2017.53.html

Linking metabolic reprogramming to therapy resistance in cancer
Andrea Morandi, Stefano Indraccolo
http://www.sciencedirect.com/science/article/pii/S0304419X16300877

Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling
Cyril Corbet, Olivier Feron
http://www.sciencedirect.com/science/article/pii/S0304419X16300944

Focus: Metabolism: Endothelial cell metabolism in health and disease: impact of hypoxia
Brian W Wong, Elke Marsch, Lucas Treps, Myriam Baes, and Peter Carmeliet
http://EMBOJ.embopress.org/content/36/15/2187?etoc

Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities
Shanmugasundaram Ganapathy-Kanniappan
http://www.sciencedirect.com/science/article/pii/S0304419X17300495

Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress
Takafumi Suzuki and Masayuki Yamamoto
http://www.jbc.org/content/early/2017/08/24/jbc.R117.800169.abstract

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
Gianmarco Rinaldi, Matteo Rossi and Sarah-Maria Fendt
http://onlinelibrary.wiley.com/doi/10.1002/wsbm.1397/epdf?author_access_token=TDOWeHnZ_PvPbtei12n1-U4keas67K9QMdWULTWMo8P6RODk2T7cshusbeUY6fcRvBil_eSIxn4qERV9tdCd4TJwl3JNLnl0uSQzEI9MRtVfguGgJusbE2Q8s_nofoaL

Sweet Sixteenth for ChREBP: Established Roles and Future Goals
Aya Abdul-Wahed, Sandra Guilmeau, Catherine Postic
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30425-4

Novel targeted therapies for cancer cachexia
Josep M. Argilés, Francisco Javier López-Soriano, Britta Stemmler, and Sílvia Busquets
http://www.biochemj.org/content/474/16/2663?etoc

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Comments
————————–

In the Hunger Games, the Winner Takes Everything
Franziska Püschel, Cristina Muñoz-Pinedo
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30151-2

ENTOSIS ENABLES A POPULATION RESPONSE TO STARVATION
Jens C. Hamann, and Michael Overholtzer
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20066&path%5B%5D=64005

The answer’s in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance
Nadine Royla & Stefan Kempa
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1338209

Extracellular vesicles: Taking metabolism on the road
Lucas B Sullivan
http://www.nature.com/nchembio/journal/v13/n9/full/nchembio.2455.html

Hitting the target in IDH2 mutant AML
Bas J. Wouters
http://www.bloodjournal.org/content/130/6/693

The RagD GTPase Regulates mTORC1 Activity to Promote Tumor Growth
http://cancerdiscovery.aacrjournals.org/content/7/8/OF18

mTORC2 Regulates the Cystine–Glutamate Antiporter xCT
http://cancerdiscovery.aacrjournals.org/content/7/8/793.2

Cyclin D3–CDK6 Has a Metabolic Prosurvival Role in T-ALL
http://cancerdiscovery.aacrjournals.org/content/7/8/OF13

——————————————————————–
One-carbon metabolism, nucleotides
——————————————————————–

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
Guillermo Burgos-Barragan, Niek Wit, Johannes Meiser, Felix A. Dingler, Matthias Pietzke, Lee Mulderrig, Lucas B. Pontel, Ivan V. Rosado, Thomas F. Brewer, Rebecca L. Cordell, Paul S. Monks, Christopher J. Chang, Alexei Vazquez & Ketan J. Patel
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23481.html

Ribonucleotide reductase represents a novel therapeutic target in primary effusion lymphoma
L Dai, Z Lin, J Qiao, Y Chen, E K Flemington and Z Qin
http://www.nature.com/onc/journal/v36/n35/abs/onc2017122a.html

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Glucose
—————–

Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport
Arvindhan Nagarajan, Shaillay Kumar Dogra, Lisha Sun, Neeru Gandotra, Thuy Ho, Guoping Cai, Gary Cline, Priti Kumar, Robert A. Cowles, Narendra Wajapeyee
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30508-7

Evidence for a direct crosstalk between malic enzyme and the pentose phosphate pathway via structural interactions
Pengbo Yao, Huishan Sun, Chang Xu, Taiqi Chen, Bing Zou, Peng Jiang, and Wenjing Du
http://www.jbc.org/content/early/2017/08/28/jbc.M117.810309.abstract

ROLE OF GLUCOSE METABOLISM RELATED GENE GLUT1 IN THE OCCURRENCE AND PROGNOSIS OF COLORECTAL CANCER
Wenming Feng, Ge Cui, Cheng-wu Tang, Xiao-lan Zhang, Chuang Dai, Yong-qiang Xu, Hui Gong, Tao Xue, Hui-hui Guo, and Ying Bao
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18090&path%5B%5D=57966

SUPPRESSION OF PYRUVATE DEHYDROGENASE KINASE-2 RE-SENSITIZES PACLITAXEL-RESISTANT HUMAN LUNG CANCER CELLS TO PACLITAXEL
Hong Sun, Anyou Zhu, Xiang Zhou, and Fengchao Wang
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16991&path%5B%5D=54361

Pyruvate kinase M knockdown induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival
Gopinath Prakasam, Rajnish Kumar Singh, Mohammad Askandar Iqbal, Sunil Kumar Saini, Ashu Bhan Tiku, and Rameshwar N.K. Bamezai
http://www.jbc.org/content/early/2017/08/04/jbc.M117.791343.abstract

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
T H Dovmark, M Saccomano, A Hulikova, F Alves and P Swietach
http://www.nature.com/onc/journal/v36/n32/abs/onc201771a.html

——————————————-
Amino acid metabolism
——————————————-

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
Alexander Muir, Laura V Danai, Dan Y Gui, Chiara Y Waingarten, Caroline A Lewis and Matthew G Vander Heiden
https://elifesciences.org/articles/27713

Critical role for arginase 2 in obesity-associated pancreatic cancer
Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, Vicente Morales-Oyarvide, Patrick J. Lenehan, Brian M. Wolpin, Mari Mino-Kenudson, Eduardo M. Torres, Nicholas Stylopoulos, Clary B. Clish & Nada Y. Kalaany
https://www.nature.com/articles/s41467-017-00331-y

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
Hayden Weng Siong Tan, Arthur Yi Loong Sim & Yun Chau Long
https://www.nature.com/articles/s41467-017-00369-y

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
Shusaku Shibutani, Hana Okazaki, and Hiroyuki Iwata
http://www.jbc.org/content/early/2017/08/14/jbc.M117.776443.abstract

Vitamin B6 is essential for serine de novo biosynthesis
Rúben J. Ramos, Mia L. Pras-Raves, Johan Gerrits, Maria van der Ham, Marcel Willemsen, Hubertus Prinsen, Boudewijn Burgering, Judith J. Jans, Nanda M. Verhoeven-Duif
https://link.springer.com/article/10.1007/s10545-017-0061-3

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Lipids
—————–

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity
Frances K. Turrell, Emma M. Kerr, Meiling Gao, Hannah Thorpe, Gary J. Doherty, Jake Cridge, David Shorthouse, Alyson Speed, Shamith Samarajiwa, Benjamin A. Hall, Meryl Griffiths and Carla P. Martins
http://genesdev.cshlp.org/content/31/13/1339.full

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer
Hui-Ming Lin, Kate L. Mahon, Jacquelyn M. Weir, Piyushkumar A. Mundra, Calan Spielman, Karen Briscoe, Howard Gurney, Girish Mallesara, Gavin Marx, Martin R. Stockler, PRIMe Consortium, Robert G. Parton, Andrew J. Hoy, Roger J. Daly, Peter J. Meikle and Lisa G. Horvath
http://onlinelibrary.wiley.com/doi/10.1002/ijc.30903/abstract

———————————————-
Metabolic reprogramming
———————————————-

Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities
Nathan J. Lanning, Joshua P. Castle, Simar J. Singh, Andre N. Leon, Elizabeth A. Tovar, Amandeep Sanghera, Jeffrey P. MacKeigan, Fabian V. Filipp and Carrie R. Graveel
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0168-x

Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
Kiyotoshi Satoh et al, and Tomoyoshi Soga
http://www.pnas.org/content/early/2017/08/24/1710366114.short

Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer.
Roy M, Finley SD
http://journal.frontiersin.org/article/10.3389/fphys.2017.00217/full

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Hypoxia / HIFs
————————–

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway
Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L. Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J. Ratcliffe, David R. Mole, Johannes Schödel
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006872

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1
Y-L Hsu, J-Y Hung, W-A Chang, Y-S Lin, Y-C Pan, P-H Tsai, C-Y Wu and P-L Kuo
http://www.nature.com/onc/journal/v36/n34/abs/onc2017105a.html

Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity
Xiaoya Ma, Huabing Zhang, Xiang Xue, and Yatrik M Shah
http://www.jbc.org/content/early/2017/08/28/jbc.M117.805655.abstract

Hypoxia induces cancer-associated cAMP/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII
Veronika Simko, Filippo Iuliano, Lucia Csaderova
https://www.nature.com/articles/s41598-017-09549-8

————————–
Mitochondria
————————–

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
Elise Saunier, Samantha Antonio, Anne Regazzetti, Nicolas Auzeil, Olivier Laprévote, Jerry W. Shay, Xavier Coumoul, Robert Barouki, Chantal Benelli, Laurence Huc & Sylvie Bortoli
https://www.nature.com/articles/s41598-017-07006-0

Insulin-like Growth Factor-1 signalling is essential for Mitochondrial Biogenesis and Mitophagy in cancer cells
Amy Lyons, Michael Coleman, Sarah Riis, Cedric Favre, Ciara H. O’Flanagan, Alexander V. Zhdanov, Dmitri B. Papkovsky, Stephen D. Hursting, and Rosemary O’Connor
http://www.jbc.org/content/early/2017/08/18/jbc.M117.792838.abstract

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase
Jiuya He, Joe Carroll, Shujing Ding, Ian M. Fearnley, and John E. Walker
http://pnas.org/content/114/34/9086.abstract.html?etoc

Fumarate Hydratase Mutations and Alterations in Leiomyoma With Bizarre Nuclei
Qing Zhang; Kate Poropatich; Julianne Ubago; Jia Xie; Xiuhua Xu; Norma Frizzell; Julie Kim; Beihua Kong; Jian-Jun Wei
https://insights.ovid.com/crossref?an=00004347-900000000-99269

—————————————————–
Starvation, nutrient sensing
—————————————————–

MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation
Alberto Delaidelli, Gian Luca Negri, Asad Jan, Brandon Jansonius, Amal El-Naggar, Jonathan K M Lim, Debjit Khan, Htoo Zarni Oo, Christopher J Carnie, Marc Remke, John M Maris, Gabriel Leprivier and Poul H Sorensen
http://www.nature.com/cdd/journal/v24/n9/abs/cdd201779a.html

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress
J Li, Q Huang, X Long, X Guo, X Sun, X Jin, Z Li, T Ren, P Yuan, X Huang, H Zhang and J Xing
http://www.nature.com/onc/journal/v36/n34/abs/onc201798a.html

Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation
Ayano Kondo, Aya Nonaka, Teppei Shimamura, Shogo Yamamoto, Tetsuo Yoshida, Tatsuhiko Kodama, Hiroyuki Aburatani, and Tsuyoshi Osawa
http://mcb.asm.org/content/37/18/e00125-17.abstract?etoc

Glycosylation of KEAP1 links nutrient sensing to redox stress signaling
Po‐Han Chen, Timothy J Smith, Jianli Wu, Priscila F Siesser, Brittany J Bisnett, Farhan Khan, Maxwell Hogue, Erik Soderblom, Flora Tang, Jeffrey R Marks, Michael B Major, Benjamin M Swarts, Michael Boyce, and Jen‐Tsan Chi
http://EMBOJ.embopress.org/content/36/15/2233?etoc

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AMPK / mTOR
—————————

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Robert W. Myers , Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M. Kurtz, Maria Trujillo, Dinko Gonzalez Trotter, Danqing Feng, Shiyao Xu, George Eiermann, Marie A. Holahan, Daniel Rubins, Stacey Conarello, Xiaoda Niu, Sandra C. Souza, Corin Miller, Jinqi Liu, Ku Lu, Wen Feng, Ying Li, Ronald E. Painter, James A. Milligan, Huaibing He, Franklin Liu, Aimie Ogawa, Douglas Wisniewski, Rory J. Rohm, Liyang Wang, Michelle Bunzel, Ying Qian, Wei Zhu, Hongwu Wang, Bindu Bennet, Lisa LaFranco Scheuch, Guillermo E. Fernandez, Cai Li, Michael Klimas, Gaochao Zhou, Margaret van Heek, Tesfaye Biftu, Ann Weber, David E. Kelley, Nancy Thornberry, Mark D. Erion, Daniel M. Kemp, Iyassu K. Sebhat
http://science.sciencemag.org/content/357/6350/507

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells
Robin Willows, Matthew J. Sanders, Bing Xiao, Bhakti R. Patel, Stephen R.Martin, Jon Read, Jon R. Wilson, Julia Hubbard, Steven J. Gamblin and David Carling
http://www.biochemj.org/content/474/17/3059?etoc

mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression
Nahid A. Khan, Joni Nikkanen, Shuichi Yatsuga, Christopher Jackson, Liya Wang, Swagat Pradhan, Riikka Kivelä, Alberto Pessia, Vidya Velagapudi, Anu Suomalainen
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30428-

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
Sang-Oh Yoon, Sejeong Shin, Florian A. Karreth, Gwen R. Buel, Mark P. Jedrychowski, David R. Plas, Shoukat Dedhar, Steven P. Gygi, Philippe P. Roux, Noah Dephoure, John Blenis
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30491-4

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Miscellaneous
—————————

DEVELOPMENT OF HEPATOCELLULAR CANCER INDUCED BY LONG TERM LOW FAT-HIGH CARBOHYDRATE DIET IN A NAFLD/NASH MOUSE MODEL
Alessandra Tessitore, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Simona Pompili, Germana Cicciarelli, Remo Barnabei, Daria Capece, Francesca Zazzeroni, Carlo Capalbo, and Edoardo Alesse
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18585&path%5B%5D=60944

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis
Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, Douglas C. Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, Alessandra Castegna
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31033-1?elsca1=etoc&elsca2=email&elsca3=2211-1247_20170815_20_7_&elsca4=Cell%20Press%7CWebinar

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Tony Teav, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova, Charlotte Muret, Koen Debackere, Massimiliano Mazzone, Hsien-Da Huang, Sarah-Maria Fendt, Julijana Ivanisevic & Ping-Chih Ho
http://www.nature.com/ni/journal/v18/n9/full/ni.3796.html

A Dynamic Metabolic Flux Analysis of Myeloid-Derived Suppressor Cells Confirms Immunosuppression-Related Metabolic Plasticity
Guillaume Goffaux, Iness Hammami & Mario Jolicoeur
https://www.nature.com/articles/s41598-017-10464-1

Glutamine fuels proliferation but not migration of endothelial cells
Boa Kim, Jia Li, Cholsoon Jang, and Zoltan Arany
http://EMBOJ.embopress.org/content/36/16/2321?etoc

Role of glutamine and interlinked asparagine metabolism in vessel formation
Hongling Huang, Saar Vandekeere, Joanna Kalucka, Laura Bierhansl, Annalisa Zecchin, Ulrike Brüning, Asjad Visnagri, Nadira Yuldasheva, Jermaine Goveia, Bert Cruys, Katleen Brepoels, Sabine Wyns, Stephen Rayport, Bart Ghesquière, Stefan Vinckier, Luc Schoonjans, Richard Cubbon, Mieke Dewerchin, Guy Eelen, and Peter Carmeliet
http://EMBOJ.embopress.org/content/36/16/2334?etoc

MetaboList – July 2017

——————–
Starvation
——————–

Entosis Is Induced by Glucose Starvation
Jens C. Hamann, Alexandra Surcel, Ruoyao Chen, Carolyn Teragawa, John G. Albeck, Douglas N. Robinson, Michael Overholtzer
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30851-3

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène, Marion Rubis, Veronique Secq, Stéphane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew G. Vander Heiden and Sophie Vasseur
https://www.nature.com/articles/ncomms16031

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias and Alec C. Kimmelman
https://www.nature.com/articles/ncomms15965

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
Truc B. Nguyen, Sharon M. Louie, Joseph R. Daniele, Quan Tran, Andrew Dillin, Roberto Zoncu, Daniel K. Nomura, James A. Olzmann
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30459-8

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells
Jun-Kyu Byun, Yeon-Kyung Choi, Ji-Hyun Kim, Ji Yun Jeong, Hui-Jeon Jeon, Mi-Kyung Kim, Ilseon Hwang, Shin-Yup Lee, You Mie Lee, In-Kyu Lee, Keun-Gyu Park
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30897-5

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival
Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, Lianfeng Wu, Ben Zhou, Lucydalila Cedillo, Michael C. Kacergis, Sean P. Curran, Alexander A. Soukas
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30899-9

Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells
H Takahashi, J Inoue, K Sakaguchi, M Takagi, S Mizutani and J Inazawa
http://www.nature.com/onc/journal/v36/n30/abs/onc201759a.html

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation
Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M. van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S. Sinsimer, Elisabeth A. Gavis, Christian Behrends, Catherine Rabouille
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30856-2

Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons
Cristian Gerónimo-Olvera, Teresa Montiel, Ruth Rincon-Heredia, Susana Castro-Obregón and Lourdes Massieu
http://www.nature.com/cddis/journal/v8/n6/full/cddis2017299a.html

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy
Derong Cui, Dawei Sun, Xintao Wang, Liye Yi, Ewa Kulikowicz, Michael Reyes, Junchao Zhu, Zeng-Jin Yang, Wei Jiang and Raymond C Koehler
http://www.nature.com/cddis/journal/v8/n7/abs/cddis2017318a.html

—————————
Nutrient sensing
—————————

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
Chen-Song Zhang ,Simon A. Hawley,Yue Zong,Mengqi Li,Zhichao Wang,Alexander Gray,Teng Ma,Jiwen Cui,Jin-Wei Feng,Mingjiang Zhu,Yu-Qing Wu,Terytty Yang Li,Zhiyun Ye,Shu-Yong Lin,Huiyong Yin, Hai-Long Piao, D. Grahame Hardie & Sheng-Cai Lin
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23275.html

Activation of the Unfolded Protein Response by Lipid Bilayer Stress
Kristina Halbleib, Kristina Pesek, Roberto Covino, Harald F. Hofbauer, Dorith Wunnicke, Inga Hänelt, Gerhard Hummer, Robert Ernst
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30439-2

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response
[yeast]
Elisa Ferrari, Christopher Bruhn, Marta Peretti, Corinne Cassani, Walter Vincenzo Carotenuto, Mohamed Elgendy, Ghadeer Shubassi, Chiara Lucca, Rodrigo Bermejo, Mario Varasi, Saverio Minucci, Maria Pia Longhese, Marco Foiani
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30367-2

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals
[yeast]
Marie-Pierre Péli-Gulli, Serena Raucci, Zehan Hu, Jörn Dengjel, Claudio De Virgilio
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30889-6

—————————————————-
Amino acid metabolism
—————————————————-

Extracellular vesicles are independent metabolic units with asparaginase activity
Nunzio Iraci, Edoardo Gaude, Tommaso Leonardi, Ana S H Costa, Chiara Cossetti, Luca Peruzzotti-Jametti, Joshua D Bernstock, Harpreet K Saini, Maurizio Gelati, Angelo Luigi Vescovi, Carlos Bastos, Nuno Faria, Luigi G Occhipinti, Anton J Enright, Christian Frezza & Stefano Pluchino
https://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2422.html

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
Yuchao Gu, Claudio P. Albuquerque, Daniel Braas, Wei Zhang, Genaro R. Villa, Junfeng Bi, Shiro Ikegami, Kenta Masui, Beatrice Gini, Huijun Yang, Timothy C. Gahman, Andrew K. Shiau, Timothy F. Cloughesy, Heather R. Christofk, Huilin Zhou, Kun-Liang Guan, Paul S. Mischel
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30394-5

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling
X Tang, C-K Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George, D P McDonnell, D S Hsu, J T Chang and J-T Chi
http://www.nature.com/onc/journal/v36/n30/abs/onc2016394a.html

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E. Johansson, Sofie Mohlin and Sven Påhlman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16904&path%5B%5D=54085

Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism
J Dong, D Xiao, Z Zhao, P Ren, C Li, Y Hu, J Shi, H Su, L Wang, H Liu, B Li, P Gao and G Qing
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201759a.html

ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma
A D Marshall, M van Geldermalsen, N J Otte, T Lum, M Vellozzi, A Thoeng, A Pang, R Nagarajah, B Zhang, Q Wang, L Anderson, J E J Rasko and J Holst
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201770a.html

——————————–
Hexose metabolism
——————————–

MPI [mannose phosphate isomerase] depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect
Nataly Shtraizent, Charles DeRossi, Shikha Nayar, Ravi Sachidanandam, Liora S Katz, Adam Prince, Anna P Koh, Adam Vincek, Yoav Hadas, Yujin Hoshida, Donald K Scott, Efrat Eliyahu, Hudson H Freeze, Kirsten C Sadler
https://elifesciences.org/articles/22477

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Surendra K. Shukla, Vinee Purohit, Kamiya Mehla, Venugopal Gunda, Nina V. Chaika, Enza Vernucci, Ryan J. King, Jaime Abrego, Gennifer D. Goode, Aneesha Dasgupta, Alysha L. Illies, Teklab Gebregiworgis, Bingbing Dai, Jithesh J. Augustine, Divya Murthy, Kuldeep S. Attri, Oksana Mashadova, Paul M. Grandgenett, Robert Powers, Quan P. Ly, Audrey J. Lazenby, Jean L. Grem, Fang Yu, José M. Matés, John M. Asara, Jung-whan Kim, Jordan H. Hankins, Colin Weekes, Michael A. Hollingsworth, Natalie J. Sarkova, Aaron R. Sasson, Jason B. Fleming, Jennifer M. Oliveto, Costas A. Lyssiotis, Lewis C. Cantley, Lyudmyla Berim, Pankaj K. Singh
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30254-4

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake
Srirupa Roy, Andrew M. Leidal, Jordan Ye, Sabrina M. Ronen, Jayanta Debnath
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30360-X

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan and S Kang
http://www.nature.com/onc/journal/v36/n27/abs/onc20176a.html

Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α
W Wan, K Peng, M Li, L Qin, Z Tong, J Yan, B Shen and C Yu
http://www.nature.com/onc/journal/v36/n27/abs/onc201713a.html

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
E A Hanse, C Ruan, M Kachman, D Wang, X H Lowman and A Kelekar
http://www.nature.com/onc/journal/v36/n27/abs/onc201736a.html

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo and Panu M. Jaakkola
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0167-y

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma
Y Shang, J He, Y Wang, Q Feng, Y Zhang, J Guo, J Li, S Li, Y Wang, G Yan, F Ren, Y Shi, J Xu, N Zeps, Y Zhai, D He and Z Chang
http://www.nature.com/onc/journal/v36/n29/abs/onc201731a.html

————–
Lipids
————–

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
Walaa Eid, Kristin Dauner, Kevin C. Courtney, AnneMarie Gagnon, Robin J. Parks, Alexander Sorisky, and Xiaohui Zha
http://www.pnas.org/content/114/30/7999.abstract.html?etoc

Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth
Elissaveta Petrova, Arne Scholz, Juliane Paul, Andrea Sturz, Katja Haike, Franziska Siegel, Dominik Mumberg and Ningshu Liu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=12650&path%5B%5D=40079

—————————————
Mitochondria / Krebs
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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge, Estelle Saland, Fabienne de Toni, Nesrine Aroua, Mohsen Hosseini, Robin Perry, Claudie Bosc, Mayumi Sugita, Lucille Stuani, Marine Fraisse, Sarah Scotland,Clément Larrue, Héléna Boutzen, Virginie Féliu, Marie-Laure Nicolau-Travers, Stéphanie Cassant-Sourdy, Nicolas Broin, Marion David, Nizar Serhan, Audrey Sarry,Suzanne Tavitian, Tony Kaoma, Laurent Vallar, Jason Iacovoni, Laetitia K. Linares, Camille Montersino, Rémy Castellano, Emmanuel Griessinger, Yves Collette, Olivier Duchamp, Yara Barreira, Pierre Hirsch, Tony Palama, Lara Gales, François Delhommeau, Barbara H. Garmy-Susini, Jean-Charles Portais, François Vergez, Mary Selak,Gwenn Danet-Desnoyers, Martin Carroll, Christian Récher and Jean-Emmanuel Sarry
http://cancerdiscovery.aacrjournals.org/content/7/7/716

Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism
Ee Phie Tan, Steven R. McGreal, Stefan Graw, Robert Tessman, Scott J. Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E. Zachara, Devin C. Koestler, Kenneth R. Peterson, John P. Thyfault, Russell H. Swerdlow, Partha Krishnamurthy, Luciano DiTacchio, Udayan Apte, and Chad Slawson
http://www.jbc.org/content/early/2017/07/24/jbc.M117.797944.abstract

Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria
Julianna Dias Zeidler, Lorena O. Fernandes-Siqueira, Ana S. Carvalho, Eduardo Cararo-Lopes, Matheus H.S. Dias, Luisa A. Ketzer, Antonio Galina, and Andrea T. Da Poian
http://www.jbc.org/content/early/2017/06/29/jbc.M117.786582.abstract

Sorafenib Targets the Mitochondrial Electron Transport Chain Complexes and ATP Synthase to Activate the PINK1-Parkin Pathway and Modulate Cellular Drug Response
Conggang Zhang, Zeyu Liu, Eric Bunker, Adrian Ramirez, Schuyler Lee, Yinghua Peng, Aik Choon Tan, S Gail Eckhardt, Douglas A Chapnick, and Xuedong Liu
http://www.jbc.org/content/early/2017/07/03/jbc.M117.783175.abstract

Targeted exome sequencing of Krebs cycle genes reveals candidate cancer predisposing mutations in pheochromocytomas and paragangliomas.
Laura Remacha, Iñaki Comino-Méndez, Susan Richter, Laura Contreras, María Currás-Freixes, Guillermo Pita, Rocío Letón, Antonio Galarreta, Rafael Torres-Pérez, Emiliano Honrado, Scherezade Jiménez, Lorena Maestre, Sebastian Moran, Manel Esteller, Jorgina Satrústegui, Graeme Eisenhofer, Mercedes Robledo and Alberto Cascón
http://clincancerres.aacrjournals.org/content/early/2017/07/18/1078-0432.CCR-16-2250

Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma
Trisha Dwight, Un Na, Edward Kim, Ying Zhu, Anne Louise Richardson, Bruce G. Robinson, Katherine M. Tucker, Anthony J. Gill, Diana E. Benn, Roderick J. Clifton-Bligh and Dennis R. Winge
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3486-z

MITOCHONDRIAL PYRUVATE CARRIER FUNCTION DETERMINES CELL STEMNESS AND METABOLIC REPROGRAMMING IN CANCER CELLS
Xiaoli Li, Gaoyang Han, Xiaoran Li, Quancheng Kan, Zhirui Fan, Yaqing Li, Yasai Ji, Jing Zhao, Mingzhi Zhang,Mantas Grigalavicius, Viktor Berge, Mariusz Adam Goscinski, Jahn M. Nesland, and Zhenhe Suo
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18199&path%5B%5D=58346

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Hypoxia, HIFs
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Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress
Meiyan Jin, Gregory G. Fuller, Ting Han, Yao Yao, Amelia F. Alessi, Mallory A. Freeberg, Nathan P. Roach, James J. Moresco, Alla Karnovsky, Misuzu Baba, John R. Yates III, Aaron D. Gitler, Ken Inoki, Daniel J. Klionsky, John K. Kim
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30930-0

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1histone methyltransferase
Abhishek A. Chakraborty , Eijiro Nakamura, Jun Qi, Amanda Creech, Jacob D. Jaffe, Joshiawa Paulk, Jesse S. Novak, Kshithija Nagulapalli, Samuel K. McBrayer, Glenn S. Cowley, Javier Pineda, Jiaxi Song, Yaoyu E. Wang, Steven A. Carr, David E. Root, Sabina Signoretti, James E. Bradner, William G. Kaelin, Jr
http://stm.sciencemag.org/content/9/398/eaal5272

Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis
Y Zhang, Y-J Ren, L-C Guo, C Ji, J Hu, H-H Zhang, Q-H Xu, W-D Zhu, Z-J Ming, Y-S Yuan, X Ren, J Song and J-M Yang
http://www.nature.com/onc/journal/v36/n29/abs/onc201751a.html

GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness
M-C Lin, J-J Lin, C-L Hsu, H-F Juan, P-J Lou and M-C Huang
http://www.nature.com/onc/journal/v36/n30/abs/onc20178a.html

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E. Johansson, Sofie Mohlin and Sven Påhlman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16904&path%5B%5D=54085

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Metformin
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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan,R obert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real & Fredrik Bäckhed
http://www.nature.com/nm/journal/v23/n7/full/nm.4345.html

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells
Camille Loubiere, Stephan Clavel, Jerome Gilleron, Rania Harisseh, Jeremy Fauconnier, Issam Ben-Sahra, Lisa Kaminski, Kathiane Laurent, Stephanie Herkenne, Sandra Lacas-Gervais, Damien Ambrosetti, Damien Alcor, Stephane Rocchi, Mireille Cormont, Jean-François Michiels, Bernard Mari, Nathalie M. Mazure, Luca Scorrano, Alain Lacampagne, Abdallah Gharib, Jean-François Tanti & Frederic Bost
https://www.nature.com/articles/s41598-017-05052-2

Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment
Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, and Yoji Andrew Minamishima
http://mcb.asm.org/content/37/16/e00248-17.abstract?etoc

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Miscellaneous
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Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation
Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30905-1

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
Jason M Tanner, Claire Bensard, Peng Wei, Nathan M Krah, John C Schell, Jamie D Gardiner, Joshua D. Schiffman, Stephen L Lessnick and Jared Rutter
http://mcr.aacrjournals.org/content/early/2017/07/18/1541-7786.MCR-17-0182

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination
Sharanya Sivanand, Seth Rhoades, Qinqin Jiang, Joyce V. Lee, Joseph Benci, Jingwen Zhang, Salina Yuan, Isabella Viney, Steven Zhao, Alessandro Carrer, Michael J. Bennett, Andy J. Minn, Aalim M. Weljie, Roger A. Greenberg, Kathryn E. Wellen
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30435-5

Brief Report: Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma
Leo Rasche, Edgardo Angtuaco, James E. McDonald, Amy Buros, Caleb Stein, Charlotte Pawlyn, Sharmilan Thanendrarajan, Carolina Schinke, Rohan Samant, Shmuel Yaccoby, Brian A. Walker, Joshua Epstein, Maurizio Zangari, Frits van Rhee, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Richard Houlston, Bart Barlogie, Faith E. Davies, Gareth J. Morgan, and Niels Weinhold
http://bloodjournal.org/content/130/1/30.abstract?etoc

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Reviews
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Metabolic Interactions in the Tumor Microenvironment
Costas A. Lyssiotis, Alec C. Kimmelman
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Gabriela Andrejeva, Jeffrey C. Rathmell
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30346-7

Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
Hsiuchen Chen, David C. Chan
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30340-6

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Rigel J. Kishton, Madhusudhanan Sukumar, Nicholas P. Restifo
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30358-3

Ancillary Activity: Beyond Core Metabolism in Immune Cells
Daniel J. Puleston, Matteo Villa, Erika L. Pearce
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30362-5

The Mitochondrial Complex(I)ty of Cancer
Felix Urra, Felipe Muñoz, Alenka Lovy, and Cesar Cardenas
http://journal.frontiersin.org/article/10.3389/fonc.2017.00118/full

Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)
Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, and Teresa W.-M. Fan
http://m.jbc.org/content/292/28/11601.abstract.html

Nutrition, inflammation and cancer
Laurence Zitvogel, Federico Pietrocola and Guido Kroemer
http://www.nature.com/ni/journal/v18/n8/full/ni.3754.html

Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy
Sergio Rey, Luana Schito, Bradly G. Wouters, Scott Eliasof, Robert S. Kerbel
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30088-2

Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome.
Settas N, Faucz FR, Stratakis CA.
https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(17)30392-1

Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis
Dario C Altieri
http://www.nature.com/bjc/journal/v117/n3/full/bjc2017201a.html

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari et al.
http://www.nature.com/ncb/journal/v19/n8/full/ncb3578.html

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Comments
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Metabolism: Energy sensing through a sugar diphosphate
Bruce E. Kemp & Jonathan S. Oakhill
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23099.html

MUC-king with HIF May Rewire Pyrimidine Biosynthesis and Curb Gemcitabine Resistance in Pancreatic Cancer
Chi V. Dang
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30257-X

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer
Ana P. Gomes, Tanya Schild, John Blenis
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30546-4

Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells
Aaron D. Schimmer
http://cancerdiscovery.aacrjournals.org/content/7/7/670

Exploiting tumour addiction with a serine and glycine-free diet
Ivano Amelio, Gerry Melino and Christian Frezza
http://www.nature.com/cdd/journal/v24/n8/full/cdd201783a.html

Lipid Droplets Guard Mitochondria during Autophagy
Till Klecker, Ralf J. Braun, Benedikt Westermann
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30506-3

A novel role for a glycolytic pathway kinase in regulating autophagy has implications in cancer therapy
Aileen R. Ariosa & Daniel J. Klionsky
http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1321723

The skinny on obesity and cancer
Jaclyn Sceneay and Sandra S. McAllister
http://www.nature.com/ncb/journal/v19/n8/full/ncb3583.html