Diet, systemic metabolism and cachexia
Activation of GPR81 by lactate drives tumour-induced cachexia – Xidan Liu, Shijin Li, Qionghua Cui, Bujing Guo, Wanqiu Ding, Jie Liu, Li Quan, Xiaochuan Li, Peng Xie, Li Jin, Ye Sheng, Wenxin Chen, Kai Wang, Fanxin Zeng, Yifu Qiu, Changlu Liu, Yan Zhang, Fengxiang Lv, Xinli Hu and Rui-Ping Xiao. https://www.nature.com/articles/s42255-024-01011-0
Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia – Franca Raucci, Claudio Vernieri, Maira Di Tano, Francesca Ligorio, Olga Blaževitš, Samuel Lazzeri, Anastasiya Shmahala, Giuseppe Fragale, Giulia Salvadori, Gabriele Varano, Stefano Casola, Roberta Buono, Euplio Visco, Filippo de Braud, Valter D. Longo. https://aacrjournals.org/cancerres/article/84/7/1133/742051
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy – Andrés Pastor-Fernández, Manuel Montero Gómez de las Heras, José Ignacio Escrig-Larena, Marta Barradas, Cristina Pantoja, Adrián Plaza, José Luis López-Aceituno, Esther Durán, Alejo Efeyan, Maria Mittelbrunn, Lola Martínez, Pablo José Fernández-Marcos. https://doi.org/10.1002/cac2.12535
Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis – Camille Lefevre, Morgane M. Thibaut, Audrey Loumaye, Jean-Paul Thissen, Audrey M. Neyrinck, Benoit Navez, Nathalie M. Delzenne, Olivier Feron, Laure B. Bindels. https://www.sciencedirect.com/science/article/pii/S2212877824000619
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans – Barry Scott, Emily A. Day, Katie L. O’Brien, John Scanlan, Grace Cromwell, Aine Ni Scannail, Marie E. McDonnell, David K. Finlay and Lydia Lynch. https://www.nature.com/articles/s42255-024-01018-7
Lac-Phe mediates the effects of metformin on food intake and body weight – Shuke Xiao, Veronica L. Li, Xuchao Lyu, Xudong Chen, Wei Wei, Fahim Abbasi, Joshua W. Knowles, Alan Sheng-Hwa Tung, Shuliang Deng, Gaurav Tiwari, Xu Shi, Shuning Zheng, Laurie Farrell, Zsu-Zsu Chen, Kent D. Taylor, Xiuqing Guo, Mark O. Goodarzi, Alexis C. Wood, Yii-Der Ida Chen, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Clary B. Clish, Usman A. Tahir, Robert E. Gerszten, Mark D. Benson and Jonathan Z. Long Show fewer authors. https://www.nature.com/articles/s42255-024-00999-9
Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring – Jonathan Sun, Enric Esplugues, Alicia Bort, Magdalena P. Cardelo, Inmaculada Ruz-Maldonado, Pablo Fernández-Tussy, Clara Wong, Hehe Wang, Iwao Ojima, Martin Kaczocha, Rachel Perry, Yajaira Suárez and Carlos Fernández-Hernando. https://www.nature.com/articles/s42255-024-01019-6
Glucose metabolism
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 – Li Ren Kong, Komal Gupta, Andy Jialun Wu, David Perera, Roland Ivanyi-Nagy, Syed Moiz Ahmed, Tuan Zea Tan, Shawn Lu-Wen Tan, Alessandra Fuddin, Elayanambi Sundaramoorthy, Grace Shiqing Goh, Regina Tong Xin Wong, Ana S.H. Costa, Callum Oddy, Hannan Wong, C. Pawan K. Patro, Yun Suen Kho, Xiao Zi Huang, Joan Choo, Mona Shehata, Soo Chin Lee, Boon Cher Goh, Christian Frezza, Jason J. Pitt, Ashok R. Venkitaraman. https://www.cell.com/cell/fulltext/S0092-8674(24)00255-1
Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation – Ryouhei Tsutsumi, Beatrix Ueberheide, Feng-Xia Liang, Benjamin G. Neel, Ryuichi Sakai and Yoshiro Saito. https://www.nature.com/articles/s41467-024-46971-9
Amino acids
Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis – Divya Murthy, Kuldeep S. Attri, Surendra K. Shukla, Ravi Thakur, Nina V. Chaika, Chunbo He, Dezhen Wang, Kanupriya Jha, Aneesha Dasgupta, Ryan J. King, Scott E. Mulder, Joshua Souchek, Teklab Gebregiworgis, Vikant Rai, Rohit Patel, Tuo Hu, Sandeep Rana, Sai Sundeep Kollala, Camila Pacheco, Paul M. Grandgenett, Fang Yu, Vikas Kumar, Audrey J. Lazenby, Adrian R. Black, Susanna Ulhannan, Ajay Jain, Barish H. Edil, David L. Klinkebiel, Robert Powers, Amarnath Natarajan, Michael A. Hollingsworth, Kamiya Mehla, Quan Ly, Sarika Chaudhary, Rosa F. Hwang, Kathryn E. Wellen and Pankaj K. Singh. https://www.nature.com/articles/s41556-024-01372-4
Lipid metabolism
Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis – Evelina Charidemou, Roberta Noberini, Chiara Ghirardi, Polymnia Georgiou, Panayiota Marcou, Andria Theophanous, Katerina Strati, Hector Keun, Volker Behrends, Tiziana Bonaldi, and Antonis Kirmizis. https://www.embopress.org/doi/full/10.1038/s44318-024-00053-0
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism – Khaled Tighanimine, José Américo Nabuco Leva Ferreira Freitas, Ivan Nemazanyy, Alexia Bankolé, Delphine Benarroch-Popivker, Susanne Brodesser, Gregory Doré, Lucas Robinson, Paule Benit, Sophia Ladraa, Yara Bou Saada, Bertrand Friguet, Philippe Bertolino, David Bernard, Guillaume Canaud, Pierre Rustin, Eric Gilson, Oliver Bischof, Stefano Fumagalli and Mario Pende. https://www.nature.com/articles/s42255-023-00972-y
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer – Takehiro Yamamoto, Tetsu Hayashida, Yohei Masugi, Kiyotaka Oshikawa, Noriyo Hayakawa, Mai Itoh, Chiyoko Nishime, Masami Suzuki, Aiko Nagayama, Yuko Kawai, Takako Hishiki, Tomomi Matsuura, Yoshiko Naito, Akiko Kubo, Arisa Yamamoto, Yujiro Yoshioka, Tomokazu Kurahori, Misa Nagasaka, Minako Takizawa, Naoharu Takano, Koji Kawakami, Michiie Sakamoto, Masatoshi Wakui, Takushi Yamamoto, Yuko Kitagawa, Yasuaki Kabe, Kenichi Horisawa, Atsushi Suzuki, Masaki Matsumoto, Makoto Suematsu. https://aacrjournals.org/cancerres/article/84/7/1065/742054
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition – Ribeiro CF, Rodrigues S, Bastos DC, Fanelli GN, Pakula H, Foiani M, Zadra G, Loda M. https://www.science.org/doi/10.1126/scisignal.adh1922
Nucleotides
DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer – Shaoqiang Guo, Miaomiao Miao, Yufeng Wu, Dongyue Pan, Qinyan Wu, Zhanfang Kang, Jianwen Zeng, Guoping Zhong, Chengfei Liu and Junjian Wang. https://www.nature.com/articles/s41388-024-03005-4
Mitochondria
Wild-type IDH2 is a therapeutic target for triple-negative breast cancer – Jiang-jiang Li, Tiantian Yu, Peiting Zeng, Jingyu Tian, Panpan Liu, Shuang Qiao, Shijun Wen, Yumin Hu, Qiao Liu, Wenhua Lu, Hui Zhang and Peng Huang. https://www.nature.com/articles/s41467-024-47536-6
Starvation, AMPK
AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand – Simon A. Hawley, Fiona M. Russell, D. Grahame Hardie. https://portlandpress.com/biochemj/article-abstract/481/8/587/234287
TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells – Suli Lv, Zongbiao Zhang, Zhenyong Li, Qian Ke, Xianyun Ma, Neng Li, Xuefeng Zhao, Qingli Zou, Lidong Sun, Tanjing Song. https://www.jbc.org/article/S0021-9258(24)01771-X
Hypoxia
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia – Fiona Grimm, Agustín Asuaje, Aakriti Jain, Mariana Silva dos Santos, Jens Kleinjung, Patrícia M Nunes, Stefanie Gehrig, Louise Fets, Salihanur Darici, James I MacRae, Dimitrios Anastasiou. https://www.embopress.org/doi/full/10.1038/s44318-024-00065-w
Cancer Immunometabolism
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells – Tianyu Cao, Wenyao Zhang, Qi Wang, Chen Wang, Wanqi Ma, Cangang Zhang, Minghui Ge, Miaomiao Tian, Jia Yu, Anjun Jiao, Liang Wang, Manjiao Liu, Pei Wang, Zhiyu Guo, Yun Zhou, Shuyi Chen, Wen Yin, Jing Yi, Hao Guo, Hua Han, Baojun Zhang, Kaichun Wu, Daiming Fan, Xin Wang, Yongzhan Nie, Yuanyuan Lu, Xiaodi Zhao. https://www.cell.com/cell/abstract/S0092-8674(24)00303-9
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos – Ma S, Sandhoff R, Luo X, Shang F, Shi Q, Li Z, Wu J, Ming Y, Schwarz F, Madi A, Weisshaar N, Mieg A, Hering M, Zettl F, Yan X, Mohr K, Ten Bosch N, Li Z, Poschet G, Rodewald HR, Papavasiliou N, Wang X, Gao P, Cui G.. https://www.science.org/doi/10.1126/sciimmunol.adg8817
Miscellaneous
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability – Keene L. AbbottA, hmed Ali, Bradley I. Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D. Landis, Rachel A. Hongo, Kirsten L. Young, Tenzin Kunchok, Christopher S. NabelKayla D. Crowder, Johnathan R. Kent, Maria Lucia L. Madariaga, Rakesh K. Jain, Kathryn E. Beckermann, Caroline A. Lewis, Clary B. Clish, Alexander Muir, W. Kimryn Rathmell, Jeffrey C. Rathmell, Matthew G. Vander Heiden. https://elifesciences.org/reviewed-preprints/95652
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma – ChuanJie Zhang, ZunGuo Du, Yi Gao, Kiat Shenq Lim, WenJie Zhou, Hai Huang, HongChao He, Jun Xiao, DanFeng Xu, QingQuan Li. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging – Anastasia D Komarova, Snezhana D SinyushkinaIlia D ShchechkinIrina N Druzhkova,Sofia A Smirnova, Vitaliy M Terekhov,Artem M Mozherov,Nadezhda I Ignatova, Elena E Nikonova, Evgeny A Shirshin, Vladislav I Shcheslavskiy, Marina V Shirmanova. https://elifesciences.org/reviewed-preprints/94438
Reviews
Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies – Aristotle Lau, John Blenis, Guillermo Burgos-Barragan. https://aacrjournals.org/cancerres/article-abstract/84/8/1191/742971
Dietary approaches for exploiting metabolic vulnerabilities in cancer – Otília Menyhárt, Balázs Győrffy. https://www.sciencedirect.com/science/article/pii/S0304419X23002111
Comments
A waste product’s unexpected role in wasting – Jack D. Sanford and Marcus D. Goncalves. https://www.nature.com/articles/s42255-024-01010-1
Targeting stromal metabolism in pancreatic ductal adenocarcinoma – Miao Yin and Qun-Ying Lei. https://www.nature.com/articles/s41556-023-01330-6
A glycolytic metabolite that drives BRCA2 haploinsufficiency – Peng Jiang. https://www.cell.com/cell/abstract/S0092-8674(24)00319-2
Tumor–Host Cometabolism Collaborates to Shape Cancer Immunity – Yingcheng Wu, Qiang Zou, Peng Jiang, Qiang Gao. https://aacrjournals.org/cancerdiscovery/article-abstract/14/4/653/741968
Fat matters for natural killer cell activity – Pamela Wong and Todd A. Fehniger. https://www.nature.com/articles/s41590-024-01825-w
Metabolism and Cancer articles 