Reductive/oxidative stress
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production – Evan K. Noch, Laura Palma, Isaiah Yim, Nayah Bullen, Daniel Barnett, Alexander Walsh, Bhavneet Bhinder, Elisa Benedetti, Jan Krumsiek, Justin Gurvitch, Sumaiyah Khwaja, Daphne Atlas, Olivier Elemento and Lewis C. Cantley. https://www.pnas.org/doi/10.1073/pnas.2317343121
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis – Xiaojian Shi, Marisa DeCiucis, Kariona A. Grabinska, Jean Kanyo, Adam Liu, Tukiet T. Lam, Hongying Shen. https://www.cell.com/molecular-cell/abstract/S1097-2765(23)01027-4
Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner – Madlen Meinert, Christina Jessen, Anita Hufnagel, Julia Katharina Charlotte Kreß, Mychal Burnworth, Theo Däubler, Till Gallasch, Thamara Nishida Xavier da Silva, Ancély Ferreira Dos Santos, Carsten Patrick Ade, Werner Schmitz, Susanne Kneitz, José Pedro Friedmann Angeli, Svenja Meierjohann. https://www.sciencedirect.com/science/article/pii/S2213231723004123
Amino acids
An engineered biosensor enables dynamic aspartate measurements in living cells – Kristian Davidsen, Jonathan S Marvin, Abhi Aggarwa, lTimothy A Brown, Lucas B Sullivan. https://elifesciences.org/articles/90024
Lipid metabolism
p53 suppresses lipid droplet–fueled tumorigenesis through phosphatidylcholine – Xiuduan Xu, Jianqin Wang, Li Xu, Peng Li, and Peng Jiang. https://www.jci.org/articles/view/171788
Hexose metabolism
UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis – Minghe Fan, Sihan Huo, Yuyao Guo, Ruoxuan Wang, Wenqin Hao, Ziyang Zhang, Lina Wang, Ying Zhao. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00136-0
p53 promotes antiviral innate immunity by driving hexosamine metabolism – Wenjun Xia, Peng Jiang. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00052-4
Metabolic stress
Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions – Wolfe AR, Cui T, Baie S, Corrales-Guerrero S, Webb A, Castro-Aceituno V, Shyu DL, Karasinska JM, Topham JT, Renouf DJ, Schaeffer DF, Halloran M, Packard R, Robb R, Chen W, Denko N, Lisanti M, Thompson TC, Frank P, Williams TM. https://www.science.org/doi/10.1126/sciadv.adj3551
AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise – Liwei Xiao, Yujing Yin, Zongchao Sun, Jing Liu, Yuhuan Jia, Likun Yang, Yan Mao, Shujun Peng, Zhifu Xie, Lei Fang, Jingya Li, Xiaoduo Xie, Zhenji Gan. https://www.science.org/doi/10.1126/sciadv.adj2752
Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism – Magdalena Kremer, Sabrina Schulze, Nadja Eisenbruch, Felix Nagel, Robert Vogt, Leona Berndt, Babett Dörre, Gottfried J. Palm, Jens Hoppen, Britta Girbardt, Dirk Albrecht, Susanne Sievers, Mihaela Delcea, Ulrich Baumann, Karin Schnetz and Michael Lammers. https://www.nature.com/articles/s41467-024-46039-8
Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation – Jaakko Mattila, Arto Viitanen, Gaia Fabris, Tetiana Strutynska, Jerome Korzelius, Ville Hietakangas. https://www.science.org/doi/10.1126/sciadv.adi2671
Cancer Immunometabolism
A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity – Xu Wang, Sheng-Qiao Fu, Xiao Yuan, Feng Yu, Qian Ji, Hao-Wen Tang, Rong-Kun Li, Shan Huang, Pei-Qi Huang, Wei-Ting Qin, Hao Zuo, Chang Du, Lin-Li Yao, Hui Li, Jun Li, Dong-Xue Li, Yan Yang, Shu-Yu Xiao, Aziguli Tulamaiti, Xue-Feng Wang, Chun-Hua Dai, Xu Zhang, Shu-Heng Jiang, Li-Peng Hu, Xue-Li Zhang, Zhi-Gang Zhang. https://www.cell.com/molecular-cell/abstract/S1097-2765(23)01034-1
Targeting oxidative phosphorylation to increase the efficacy of immune-combination therapy in renal cell carcinoma – Jihua Tian, Jing Luo, Xing Zeng, Chunjin Ke, Yanan Wang, Zhenghao Liu, Le Li, Yangjun Zhang, Zhiquan Hu and Chunguang Yang. https://jitc.bmj.com/content/12/2/e008226
Nutrient availability regulates the secretion and function of immune cell-derived extracellular vesicles through metabolic rewiring – Wang Y, Lou P, Xie Y, Liu S, Li L, Wang C, Du D, Chen Y, Lu Y, Cheng J, Liu J.. https://www.science.org/doi/10.1126/sciadv.adj1290
Miscellaneous
NF1 deficiency drives metabolic reprogramming in ER+ breast cancer – Rachel (Rae) J. House, Elizabeth A. Tovar, Luke N. Redlon, Curt J. Essenburg, Patrick S. Dischinger, Abigail E. Ellis, Ian Beddows, Ryan D. Sheldon, Evan C. Lien, Carrie R. Graveel, Matthew R. Steensma. https://www.sciencedirect.com/science/article/pii/S2212877824000073?via%3Dihub
Reviews
Reductive stress in cancer: coming out of the shadows – Maolin Ge, Thales Papagiannakopoulos, Liron Bar-Peled. https://www.cell.com/trends/cancer/abstract/S2405-8033(23)00213-3
Lipid droplets provide metabolic flexibility for cancer progression – Rémi Safi, Pablo Menéndez, Albert Pol. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14820
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology – Carmine Settembre and Rushika M. Perera. https://www.nature.com/articles/s41580-023-00676-x
Immunosurveillance encounters cancer metabolism – Yu-Ming Chuang, Sheue-Fen Tzeng, Ping-Chih Ho, Chin-Hsien Tsai. https://www.embopress.org/doi/full/10.1038/s44319-023-00042-0
Transcellular Barriers to Glucose Delivery in the Body – Amira Klip, Katrien De Bock, Philip J. Bilan, and Erik A. Richter. https://www.annualreviews.org/doi/full/10.1146/annurev-physiol-042022-031657
Comments
SLC25A39 links mitochondrial GSH sensing with iron metabolism – Xiong Chen, Boyi Gan. https://www.cell.com/molecular-cell/abstract/S1097-2765(23)01083-3
Cholesterol-fuelled glioblastoma – Gabrielle Brewer. https://www.nature.com/articles/s41568-024-00672-z
Metabolism and Cancer articles 