Amino acid metabolism
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer – Ray Pillai, Sarah E. LeBoeuf, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Thales Papagiannakopoulos. https://www.science.org/doi/10.1126/sciadv.adm9859
Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells – Theresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak, Thomas Eichmann, Harald C Köfeler, Katharina Leithner. https://doi.org/10.1186/s40170-024-00337-3
Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer – M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin. https://www.sciencedirect.com/science/article/pii/S2212877824000310
Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer – Xinlu Han, Deyu Wang, Liao Yang, Ning Wang, Jianliang Shen, Jinghan Wang, Lei Zhang, Li Chen, Shenglan Gao, Wei-Xing Zong and Yongbo Wang. https://www.pnas.org/doi/10.1073/pnas.2319429121
Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer – Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Yiwei Huang, Tao Lu, Huan Zhang, Xing Jin, Zhencong Chen, Mengnan Zhao, Hong Fan, Qun Wang, Boyi Gan and Cheng Zhan. https://www.nature.com/articles/s41467-024-46776-w
The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling – Divya Murthy, Kuldeep S. Attri, Voddu Suresh, Girish H. Rajacharya, Carlos A. Valenzuela, Ravi Thakur, Junzhang Zhao, Surendra K. Shukla, Nina V. Chaika, Drew LaBreck, Chinthalapally V. Rao, Michael A. Hollingsworth, Kamiya Mehla and Pankaj K. Singh. https://www.pnas.org/doi/10.1073/pnas.2315509121
Filament formation drives catalysis by glutaminase enzymes important in cancer progression – Shi Feng, Cody Aplin, Thuy-Tien T. Nguyen, Shawn K. Milano and Richard A. Cerione. https://www.nature.com/articles/s41467-024-46351-3
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis – Bing Deng, Fang Liu, Nana Chen, Xinhao Li, Jie Lei, Ning Chen, Jingjing Wu, Xuan Wang, Jie Lu, Mouxiang Fang, Ailin Chen, Zijian Zhang, Bin He, Min Yan, Yuchen Zhang, Zifeng Wang and Quentin Liu. https://www.nature.com/articles/s41419-024-06577-x
Glucose metabolism, starvation
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle – Mohaned Benzarti, Laura Neises, Anais Oudin, Christina Krötz, Elodie Viry, Ernesto Gargiulo, Coralie Pulido, Maryse Schmoetten, Vitaly Pozdeev, Nadia I. Lorenz, Michael W. Ronellenfitsch, David Sumpton, Marc Warmoes, Christian Jaeger, Antoine Lesur, Björn Becker, Etienne Moussay, Jerome Paggetti, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00196-7
ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1 – Jordina Rincon-Torroella, Marco Dal Molin, Brian Mog, Gyuri Han, Evangeline Watson, Nicolas Wyhs, Shun Ishiyama, Taha AhmednaIl Minn, Nilofer S. Azad, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Bert Vogelstein, Kathleen Gabrielson, Surojit Sur. https://elifesciences.org/reviewed-preprints/94488
Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression – Fatima Khan, Yiyun Lin, Heba Ali, Lizhi Pang, Madeline Dunterman, Wen-Hao Hsu, Katie Frenis, R. Grant Rowe, Derek A. Wainwright, Kathleen McCortney, Leah K. Billingham, Jason Miska, Craig Horbinski, Maciej S. Lesniak and Peiwen Chen. https://www.nature.com/articles/s41467-024-46193-z
The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion – Shreyas Niphadkar, Lavanya Karinje, Sunil Laxman. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011202
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway – Nan Zhang, Lu Dong, Tingting Ning, Feng Du, Mengran Zhao, Junxuan Xu, Sian Xie, Si Liu, Xiujing Sun, Peng Li, Shutian Zhang and Shengtao Zhu. https://www.nature.com/articles/s41389-024-00514-5
Lipid/nucleotide metabolism
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis – Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O’Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra. https://www.science.org/doi/10.1126/science.adh2771
Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity – Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V. Tellman, Caroline F. Ribeiro, Riccardo Muzzioli, Brittany E. Jewell, Hubert Pakula, Jeffrey J. Ackroyd, Mollianne M. Murray, Jenny J. Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, Jingjing Liu, Xingzhi Song, Jianhua Zhang, Albert R. Klekers, Justin M. Drake, Michael M. Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C. Farach-Carson, Massimo Loda, Livia S. Eberlin, Daniel E. Frigo. https://aacrjournals.org/cancerres/article-abstract/84/5/703/734936
NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells – Yuhki Saito, Yanhong Yang, Misa Saito, Christopher Y. Park, Kosuke Funato, Viviane Tabar and Robert B. Darnell. https://www.pnas.org/doi/10.1073/pnas.2314695121
The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues – Hudson W. Coates, Tina B. Nguyen, Ximing Du, Ellen M. Olzomer, Rhonda Farrell, Frances L. Byrne, Hongyuan Yang, Andrew J. Brown. https://www.jbc.org/article/S0021-9258(24)01729-0/fulltext
Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1 – Tristen Wright, Meghan E. Turnis, Christy R. Grace, Xiao Li, Lauren A. Brakefield, Yong-Dong Wang, Haiyan Xu, Ewa Kaminska, Leslie K. Climer, Tresor O. Mukiza, Chi-Lun Chang, Tudor Moldoveanu, Joseph T. Opferman. https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00176-X
mTOR
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway – Grace Y. Liu, Patrick Jouandin, Raymond E. Bahng, Norbert Perrimon and David M. Sabatini. https://www.nature.com/articles/s41467-024-46680-3
Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver – Ana Belén Plata-Gómez, Lucía de Prado-Rivas, Alba Sanz, Nerea Deleyto-Seldas, Fernando García, Celia de la Calle Arregui, Camila Silva, Eduardo Caleiras, Osvaldo Graña-Castro, Elena Piñeiro-Yáñez, Joseph Krebs, Luis Leiva-Vega, Javier Muñoz, Ajay Jain, Guadalupe Sabio and Alejo Efeyan. https://www.nature.com/articles/s41467-024-46032-1
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing – Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez and G. Vignir Helgaso. https://www.nature.com/articles/s41467-024-46114-0
TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania – Elmarie Myburgh, Vincent Geoghegan, Eliza VC Alves-Ferreira, Y Romina Nievas, Jaspreet S Grewal, Elaine Brown, Karen McLuskey, Jeremy C Mottram. https://www.embopress.org/doi/full/10.1038/s44319-024-00084-y
Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes – Yoshiaki Kamada; Chiharu Umeda; Yukio Mukai; Hokuto Ohtsuka; Yoko Otsubo; Akira Yamashita; Takahiro Kosugi. https://journals.biologists.com/jcs/article/137/4/jcs261625/344020
Cancer Immunometabolism
Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells – Rui Ding, Xiaoyan Yu, Zhilin Hu, Yu Dong, Haiyan Huang, Yuerong Zhang, Qiaoqiao Han, Zhi-Yu Ni, Ren Zhao, Youqiong Ye, Qiang Zou . https://www.cell.com/immunity/abstract/S1074-7613(24)00045-1
Fatty acid oxidation fuels natural killer cell responses against infection and cancer – Sam Sheppard, Katja Srpan, Wendy Lin, Mariah Lee, Rebecca B. Delconte, Mark Owyong, Peter Carmeliet, Daniel M. Davis, Joao B. Xavier, Katharine C. Hsu and Joseph C. Sun. https://www.pnas.org/doi/10.1073/pnas.2319254121
Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation – Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McCullough, Angelo D’Alessandro, Nathaniel W. Snyder, Darren A. Cusanovich, James J. Galligan . https://www.sciencedirect.com/science/article/pii/S221287782400019X
EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth – Alexandra Kuhlmann-Hogan, Thekla Cordes, Ziyan Xu, Ramya S. Kuna, Kacie A. Traina, Camila Robles-Oteíza, Deborah Ayeni, Elizabeth M. Kwong, Stellar Levy, Anna-Maria Globig, Matthew M. Nobari, George Z. Cheng, Sandra L. Leibel, Robert J. Homer, Reuben J. Shaw, Christian M. Metallo, Katerina Politi, Susan M. Kaech. https://aacrjournals.org/cancerdiscovery/article-abstract/14/3/524/734906
Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells – Cegui Hu, Wen Qiao, Xiang Li, Zhi-kun Ning, Jiang Liu, Sumiya Dalangood, Hanjun Li, Xiang Yu, Zhen Zong, Zhenke Wen, Jun Gui. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00006-8
Mitochondria
Mitochondrial ATP generation is more proteome efficient than glycolysis – Yihui Shen, Hoang V. Dinh, Edward R. Cruz, Zihong Chen, Caroline R. Bartman, Tianxia Xiao, Catherine M. Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I. Hendry, Vinh G. Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D. Maranas, Martin Wühr and Joshua D. Rabinowitz. https://www.nature.com/articles/s41589-024-01571-y
H2S preconditioning induces long-lived perturbations in O2 metabolism – David A. Hanna, Jutta Diessl, Arkajit Guha, Roshan Kumar, Anthony Andren, Costas Lyssiotis and Ruma Banerjee. https://www.pnas.org/doi/10.1073/pnas.2319473121
The HRI branch of the integrated stress response selectively triggers mitophagy – Yogaditya Chakrabarty, Zheng Yang, Hsiuchen Chen, David C. Chan. https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00052-2
Mitochondria in AML
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia – Yongwei Su, Jenna L. Carter, Xinyu Li, Yu Fukuda, Ashley Gray, John Lynch, Holly Edwards, Jun Ma, Patrick Schreiner, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Steven A. Buck, Shondra M. Pruett-Miller, Katie Hege-Hurrish, Camenzind Robinson, Xinan Qiao, Shuang Liu, Shuangshuang Wu, Guan Wang, Jing Li, Joshua E. Allen, Varun V. Prabhu, Aaron D. Schimmer, Dhananjay Joshi, Shiva Kalhor-Monfared, Iain D. G. Watson, Richard Marcellus, Methvin B. Isaac, Rima Al-awar, Jeffrey W. Taub, Hai Lin, John D. Schuetz, Yubin Ge. https://aacrjournals.org/cancerres/article-abstract/84/7/1084/742053
Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia – Andrew J. Monteith, Haley E. Ramsey, Alexander J. Silver, Donovan Brown, Dalton Greenwood, Brianna N. Smith, Ashley D. Wise, Juan Liu, Sarah D. Olmstead, Jackson Watke, Maria P. Arrate, Agnieszka E. Gorska, Londa Fuller, Jason W. Locasale, Matthew C. Stubbs, Jeffrey C. Rathmell, Michael R. Savona. https://aacrjournals.org/cancerres/article-abstract/84/7/1101/742039
SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells – Mu-Jie Lu, Jonathan Busquets, Valeria Impedovo, Crystal N. Wilson, Hsin-Ru Chan, Yu-Tai Chang, William Matsui, Stefano Tiziani, Xiaolu A. Cambronne. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00013-5
Targeting Metabolic Dependencies Fueling the TCA Cycle to Circumvent Therapy Resistance in Acute Myeloid Leukemia – Emeline Boët; Jean-Emmanuel Sarry. https://aacrjournals.org/cancerres/article-abstract/84/7/950/742048
Miscellaneous
Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors – Léo Aubert, Estelle Bastien, Ophélie Renoult, Céline Guilbaud, Kübra Özkan, Davide Brusa, Caroline Bouzin, Elena Richiardone, Corentin Richard, Romain Boidot, Daniel Léonard, Cyril Corbet, Olivier Feron. https://www.embopress.org/doi/full/10.1038/s44319-024-00089-7
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression – Junyi Hu, Shao-Gang Wang, Yaxin Hou, Zhaohui Chen, Lilong Liu, Ruizhi Li, Nisha Li, Lijie Zhou, Yu Yang, Liping Wang, Liang Wang, Xiong Yang, Yichen Lei, Changqi Deng, Yang Li, Zhiyao Deng, Yuhong Ding, Yingchun Kuang, Zhipeng Yao, Yang Xun, Fan Li, Heng Li, Jia Hu, Zheng Liu, Tao Wang, Yi Hao, Xuanmao Jiao, Wei Guan, Zhen Tao, Shancheng Ren and Ke Chen. https://www.nature.com/articles/s41588-024-01662-5
Molecular imaging of tumor metabolism: Insight from pyruvate- and glucose-based deuterium MRI studies – Elton T Montrazi, Keren Sasson, Lilach Agemy, Avigdor Scherz, Lucio Frydman. https://www.science.org/doi/full/10.1126/sciadv.adm8600
Reviews
Growth Signaling Networks Orchestrate Cancer Metabolic Networks – Manning BD, Dibble CC. https://perspectivesinmedicine.cshlp.org/content/early/2024/03/01/cshperspect.a041543.long
The pleiotropic functions of reactive oxygen species in cancer – Katherine Wu, Ahmed Ezat El Zowalaty, Volkan I. Sayin and Thales Papagiannakopoulos. https://www.nature.com/articles/s43018-024-00738-9
The Integrated Stress Response in metabolic adaptation – Hyung Don Ryoo. https://www.jbc.org/article/S0021-9258(24)01646-6/fulltext
Metabolic interplay: tumor macrophages and regulatory T cells – Stefania Vilbois, Yingxi Xu, Ping-Chih Ho. https://www.cell.com/trends/cancer/fulltext/S2405-8033(23)00238-8
Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology – Javier A. Menendez, Elisabet Cuyàs, Jose Antonio Encinar, Travis Vander Steen, Sara Verdura, Àngela Llop-Hernández, Júlia López, Eila Serrano-Hervás, Sílvia Osuna, Begoña Martin-Castillo, Ruth Lupu. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13582
Comments
Glutamine antagonists may KEAP lung cancer in check – ELIOT B. BLATT, RALPH J. DEBERARDINIS. https://www.science.org/doi/10.1126/sciadv.ado7808
Inferring cancer metabolism from gene-expression data – Vakul Mohanty. https://www.nature.com/articles/s41568-024-00670-1
Integrating the response to stressed mitochondria – Elliot Dine, Richard J. Youle. https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00168-0
Metabolism and Cancer articles 