Starvation
Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids – Yao Rong, Alicia M. Darnell, Kiera M. Sapp, Matthew G. Vander Heiden, Sabrina L. Spencer. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01551-6
Bilayer tension-induced clustering of the UPR sensor IRE1 -Md Zobayer Hossain, Wylie Stroberg.. https://www.sciencedirect.com/science/article/abs/pii/S000527362300144X
Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo – Swati Gaikwad, Fardin Ghobakhlou, Hongen Zhang, Alan G. Hinnebusch. https://elifesciences.org/reviewed-preprints/92916
Nutrient sensing: mTOR
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency – Meng-Kai Ge, Cheng Zhang, Na Zhang, Ping He, Hai-Yan Cai, Song Li, Shuai Wu, Xi-Li Chu, Yu-Xue Zhang, Hong-Ming Ma, Li Xia, Shuo Yang, Jian-Xiu Yu, Shi-Ying Yao, Xiao-Long Zhou, Bing Su, Guo-Qiang Chen, Shao-Ming Shen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00385-6
VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes – Tianyu Zhao, Yuanyuan Guan, Chenchen Xu, Dong Wang, Jialiang Guan and Ying Liu. https://www.nature.com/articles/s41467-023-44241-8
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2 – Cong Jiang, Jing Liu, Shaohui He, Wei Xu, Runzhi Huang, Weijuan Pan, Xiaolong Li, Xiaoming Dai, Jianping Guo, Tao Zhang, Hiroyuki Inuzuka, Ping Wang, John M. Asara, Jianru Xiao, Wenyi Wei. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00411-4
The HACE1 E3 ligase mediates RAC1‐dependent control of mTOR signaling complexes – Busra Turgu, Amal El-Naggar, Melanie Kogler, Luigi Tortola, Hai-Feng Zhang, Mariam Hassan, Michael M Lizardo, Sonia HY Kung, Wan Lam, Josef M Penninger, Poul H Sorensen. https://www.embopress.org/doi/full/10.15252/embr.202356815
Amino acid metabolism
Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth – Aida Rashidi, Leah K. Billingham, Andrew Zolp, Tzu-yi Chia, Caylee Silvers, Joshua L. Katz, Cheol H. Park, Suzi Delay, Lauren Boland, Yuheng Geng, Steven M. Markwell, Crismita Dmello, Victor A. Arrieta, Kaylee Zilinger, Irene M. Jacob, Aurora Lopez-Rosas, David Hou, Brandyn Castro, Alicia M. Steffens, Kathleen McCortney, Jordain P. Walshon, Mariah S. Flowers, Hanchen Lin, Hanxiang Wang, Junfei Zhao, Adam Sonabend, Peng Zhang, Atique U. Ahmed, Daniel J. Brat, Dieter H. Heiland, Catalina Lee-Chang, Maciej S. Lesniak, Navdeep S. Chandel, Jason Miska. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00457-6
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells – Samantha J. Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D. Sullivan, Matthew D. Galbraith, Caroline A. Lewis, Christina M. Ferrer, Ruben Boon, Giorgia G. Silveira, Hyo Min Cho, Charles Vidoudez, Stuti Shroff, Joao P. Oliveira-Costa, Kenneth N. Ross, Rami Massri, Yusuke Matoba, Eugene Kim, Bo R. Rueda, Shannon L. Stott, Eyal Gottlieb, Joaquin M. Espinosa and Raul Mostoslavsky. https://www.nature.com/articles/s42255-023-00919-3
Phenotypic profiling of solute carriers characterizes serine transport in cancer – Vasileios Papalazarou, Alice C. Newman, Alejandro Huerta-Uribe, Nathalie M. Legrave, Mattia Falcone, Tong Zhang, Lynn McGarry, Dimitris Athineos, Emma Shanks, Karen Blyth, Karen H. Vousden and Oliver D. K. Maddocks. https://www.nature.com/articles/s42255-023-00936-2
Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway – Cheng Zhang, Jiao-Jiao Yu, Chen Yang, Zhen-Long Yuan, Hui Zeng, Jun-Jian Wang, Shuang Shang Xiao-Xi Lv, Xiao-Tong Liu Jing Liu, Qi Xue Bing Cui, Feng-Wei Tan, Fang Hua. https://www.science.org/doi/10.1126/scitranslmed.ade4113
Lipid metabolism and enzymes
Proteolytic activation of fatty acid synthase signals pan-stress resolution – Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinis and Benjamin P. Weaver. https://www.nature.com/articles/s42255-023-00939-z
Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression – Lijie Zhou, Yongbo Luo, Yuenan Liu, Youmiao Zeng, Junwei Tong, Mengting Li, Yaxin Hou, Kaixuan Du, Yabin Qi, Wenbang Pan, Yuanhao Liu, Rongli Wang, Fengyan Tian, Chaohui Gu, Ke Chen. https://aacrjournals.org/cancerres/article/83/23/3920/730147/
Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer – Ru-Hong Tu, Sheng-Ze Wu, Ze-Ning Huang, Qing Zhong, Yin-Hua Ye, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Chang-Ming Huang, Mi Lin, Jun Lu, Long-Long Cao, Ping Li. https://aacrjournals.org/cancerres/article-abstract/83/23/3868/730150
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer – Yingsheng Zhang, Meng-Ju Wu, Wan-Chi Lu, Yi-Chuan Li, Chun Ju Chang, Jer-Yen Yang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00455-2
Nucleotides
NAD+ regulates nucleotide metabolism and genomic DNA replication – Sebastian Howen Nesgaard Munk, Joanna Maria Merchut-Maya, Alba Adelantado Rubio, Arnaldur Hall, George Pappas, Giacomo Milletti, MyungHee Lee, Lea Giørtz Johnsen, Per Guldberg, Jiri Bartek and Apolinar Maya-Mendoza. https://www.nature.com/articles/s41556-023-01280-z
SERS analysis of cancer cell-secreted purines reveals a unique paracrine crosstalk in MTAP-deficient tumors – Pablo S. Valera, Javier Plou, Isabel García, Ianire Astobiza, Cristina Viera, Ana M. Aransay, José E. Martin, Ivan R. Sasselli, Arkaitz Carracedo and Luis M. Liz-Marzán. https://www.pnas.org/doi/10.1073/pnas.2311674120
Mitochondria and iron
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype – Mate Maus, Vanessa López-Polo, Lidia Mateo, Miguel Lafarga, Mònica Aguilera, Eugenia De Lama, Kathleen Meyer, Anna Sola, Cecilia Lopez-Martinez, Ines López-Alonso, Marc Guasch-Piqueras, Fernanda Hernandez-Gonzalez, Selim Chaib, Miguel Rovira, Mayka Sanchez, Rosa Faner, Alvar Agusti, Rodrigo Diéguez-Hurtado, Sagrario Ortega, Anna Manonelles, Stefan Engelhardt, Freddy Monteiro, Camille Stephan-Otto Attolini, Neus Prats, Guillermo Albaiceta, Josep M. Cruzado and Manuel Serrano. https://www.nature.com/articles/s42255-023-00928-2
CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma – Karen L. Burger; Mario R. Fernandez; Mark B. Meads; Praneeth Sudalagunta; Paula S. Oliveira, Rafael Renatino Canevarolo, Raghunandan Reddy Alugubelli, Alexandre Tungsevik, Gabe De Avila, Maria Silva, Allison I. Graeter, Hongyue A. Dai, Nicole D. Vincelette, Antony Prabhu, Dario Magaletti, Chunying Yang, Weimin Li, Amit Kulkarni, Oliver Hampton, John M. Koomen, William R. Roush, Andrii Monastyrskyi, Anders E. Berglund, Ariosto S. Silva, John L. Cleveland, and Kenneth H. Shain. https://aacrjournals.org/cancerres/article/83/23/3901/730149
Glucose metabolism
Application and development of Deuterium Metabolic Imaging in tumor glucose metabolism: visualization of different metabolic pathways – Jiayu Wan, Yusheng Guo, Hebing Chen, Peng Sun, Xiaoxiao Zhang, Tianhe Ye,, Lingli Li, Feng Pan, Lian Yang. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1285209/full
Fructose-Induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy – Yanfen Cui, Jianfei Tian, Zhaosong Wang, Hui Guo, He Zhang, Zhiyong Wang, Hui Liu, Weijie Song, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Ruifang Niu, Fei Zhang. https://aacrjournals.org/cancerres/article/83/24/4063/731563
Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence – Nikita Sushentsev, Gregory Hamm, Jack Richings, Mary A. McLean, Ines Horvat Menih, Vinay Ayyappan, Ian G. Mills, Anne Y. Warren, Vincent J. Gnanapragasam, Simon T. Barry, Richard J. A. Goodwin, Ferdia A. Gallagher and Tristan Barrett. https://www.pnas.org/doi/10.1073/pnas.2312261120
Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2 – Claudia Abbruzzese, Silvia Matteoni, Paola Matarrese, Michele Signore, Barbara Ascione, Elisabetta Iessi, Aymone Gurtner, Andrea Sacconi, Lucia Ricci-Vitiani, Roberto Pallini, Andrea Pace, Veronica Villani, Andrea Polo, Susan Costantini, Alfredo Budillon, Gennaro Ciliberto and Marco G. Paggi. https://www.nature.com/articles/s41419-023-06353-3
Cancer Immunometabolism
Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses – Yuerong Zhang, Xiaoyan Yu, Rujuan Bao, Haiyan Huang, Chuanjia Gu, Qianming Lv, Qiaoqiao Han, Xian Du, Xu-Yun Zhao, Youqiong Ye, Ren Zhao, Jiayuan Sun, Qiang Zou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00367-4
The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma – Richard Miallot, Virginie Millet, Anais Roger, Romain Fenouil, Catherine Tardivel, Jean-Charles Martin, Fabrice Tranchida, Laetitia Shintu, Paul Berchard, Juliane Sousa Lanza, Bernard Malissen, Sandrine Henri, Sophie Ugolini, Aurélie Dutour, Pascal Finetti, François Bertucci, Jean-Yves Blay, Franck Galland, Philippe Naquet. https://www.life-science-alliance.org/content/6/12/e202302200
Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity – Chen et al. https://www.science.org/doi/10.1126/sciadv.adf9522
Diet, systemic metabolism and cachexia
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation – Anni M.Y. Zhang, Yi Han Xia, Jeffrey S.H. Lin, Ken H. Chu, Wei Chuan K. Wang, Titine J.J. Ruiter, Jenny C.C. Yang, Nan Chen, Justin Chhuor, Shilpa Patil, Haoning Howard Cen, Elizabeth J. Rideout, Vincent R. Richard, David F. Schaeffer, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Janel L. Kopp. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00372-8
GDF15 is a major determinant of ketogenic diet-induced weight loss – Jun Feng Lu, Meng Qing Zhu, Bo Xia, Na Na Zhang, Xiao Peng Liu, Huan Liu, Rui Xin Zhang, Jun Ying Xiao, Hui Yang, Ying Qi Zhang, Xiao Miao Li, Jiang Wei Wu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00414-X
Breast adipose tissue‐derived extracellular vesicles from obese women alter tumor cell metabolism – Shuchen Liu, Alberto Benito-Martin, Fanny A Pelissier Vatter, Sarah Z Hanif, Catherine Liu, Priya Bhardwaj, Praveen Sethupathy, Alaa R Farghli, Phoebe Piloco, Paul Paik, Malik Mushannen, Xue Dong, David M Otterburn, Leslie Cohen, Rohan Bareja, Jan Krumsiek, Leona Cohen-Gould, Samuel Calto, Jason A Spector, Olivier Elemento, David C Lyden, Kristy A Brown. https://www.embopress.org/doi/full/10.15252/embr.202357339
Miscellaneous
Histone lactylation couples cellular metabolism with developmental gene regulatory networks – Fjodor Merkuri, Megan Rothstein and Marcos Simoes-Costa. https://www.nature.com/articles/s41467-023-44121-1
Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation – Qianmin Ou, Xinhua Qiao, Zhengshi Li, Luhan Niu, Fangcao Lei, Ruifeng Cheng, Ting Xie, Ning Yang, Yao Liu, Ling Fu, Jing Yang, Xueli Mao, Xiaoxing Kou, Chang Chen, Songtao Shi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00444-8
Glycine homeostasis requires reverse SHMT flux – Matthew J. McBride, Craig J. Hunter, Zhaoyue Zhang, Tara TeSlaa, Xincheng Xu, Gregory S. Ducker, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00452-7
Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD – Alia Ghrayeb, Alexandra C. Finney, Bella Agranovich, Daniel Peled, Sumit Kumar Anand, M. Peyton McKinney, Mahasen Sarji, Dongshan Yang, Natan Weissman, Shani Drucker, Sara Isabel Fernandes, Jonatan Fernández-García, Kyle Mahan, Zaid Abassi, Lin Tan, Philip L. Lorenzi, James Traylor, Jifeng Zhang, Ifat Abramovich, Y. Eugene Chen, Oren Rom, Inbal Mor, Eyal Gottlieb. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00464-3
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy – Cesar A. Perez-Ramirez, Haruko Nakano, Richard C. Law, Nedas Matulionis, Jennifer Thompson, Andrew Pfeiffer, Junyoung O. Park, Atsushi Nakano, Heather R. Christofk. https://www.cell.com/cell/fulltext/S0092-8674(23)01228-X
Reviews
The dual role of citrate in cancer – Philippe Icard, Luca Simula, Grit Zahn, Marco Alifano, Maria E. Mycielska. https://www.sciencedirect.com/science/article/abs/pii/S0304419X23001361
Deciphering the Warburg Effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation – Albert M. Li and Jiangbin Ye. https://www.annualreviews.org/doi/abs/10.1146/annurev-cancerbio-062822-120857
Biological function, regulatory mechanism, and clinical application of mannose in cancer – Haoyi Jin, Xi Liu, Hong-xu Liu. https://www.sciencedirect.com/science/article/abs/pii/S0304419X23001191
Dietary fat and lipid metabolism in the tumor microenvironment – Swagata Goswami, Qiming Zhang, Cigdem Elif Celik, Ethan M. Reich, Ömer H. Yilmaz. https://www.sciencedirect.com/science/article/abs/pii/S0304419X23001336
Tumor lipid metabolism: a mechanistic link between diet and cancer progression – Yu-Jin Jeong, Thomas J Rogers, Carolyn E Anderson, Evan C Lien. https://www.sciencedirect.com/science/article/abs/pii/S0958166923001039
Nutrient inputs and social metabolic control of T cell fate – Zachary A. Bacigalupa, Madelyn D. Landis, Jeffrey C. Rathmell. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00460-6
Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response – Louise Ramos, Martin Henriksson, Thomas Helleday, Alanna C. Green. https://aacrjournals.org/cancerres/article-abstract/84/1/9/731822
Comments
TAMC-derived creatine sustains glioblastoma growth – Huiwen Yan, Pengcheng Bu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00463-1
Delineating a Role for Methionine Metabolism in Colorectal Cancer – Shiyu Liu, Jason W. Locasale. https://aacrjournals.org/cancerres/article-abstract/83/23/3833/730137
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination – Estela Jacinto. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00417-5
Glioma Response to IDH Inhibition: Real-World Experience – Rimas V. Lukas, Craig Horbinski. https://aacrjournals.org/clincancerres/article-abstract/29/23/4709/730210
Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism – Michal J. Nagiec, John Blenis. https://www.cell.com/current-biology/fulltext/S0960-9822(23)01489-6
H2S serves as the immunoregulatory essence of apoptotic cell death – Christopher Hine, András K. Ponti, María Ángeles Cáliz-Molina, Alejandro Martín-Montalvo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00457-6
Spatial metabolic patterns – Anna Dart. https://www.nature.com/articles/s41568-023-00654-7
Conference
Cancer Metabolism (EACR). Bilbao, Spain : 8 – 10 October 2024
Organized by: Arkaitz Carracedo, Spain (Chair), Matthew Vander Heiden, Karen Vousden, Alexia-Ileana Zaromytidou. https://eacr.org/conference/cancermetabolism2024/index
46th Symposium on Hormones and Cell Regulation: “Cancer Signalling and Metabolism”.
Organized by: M. Sibilia, D. Carling . 9 to 12 October 2024, Mont Sainte-Odile, France. https://hormones-cell-regulation.eu/
Metabolism and Cancer articles 