Nucleotides
De novo and salvage purine synthesis pathways across tissues and tumors – Diem H. Tran, Dohun Kim, Rushendhiran Kesavan, Harrison Brown, Trishna Dey, Mona Hoseini Soflaee, Hieu S. Vu, Alpaslan Tasdogan, Jason Guo, Divya Bezwada, Houssam Al Saad, Feng Cai, Ashley Solmonson, Halie Rion, Rawand Chabatya, Salma Merchant, Nathan J. Manales, Vanina T. Tcheuyap, Megan Mulkey, Thomas P. Mathews, James Brugarolas, Sean J. Morrison, Hao Zhu, Ralph J. DeBerardinis, Gerta Hoxhaj. https://www.cell.com/cell/fulltext/S0092-8674%2824%2900520-8
Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance – Tommaso Scolaro, Marta Manco, Mathieu Pecqueux, Ricardo Amorim, Rosa Trotta, Heleen H. Van Acker, Matthias Van Haele, Niranjan Shirgaonkar, Stefan Naulaerts, Jan Daniluk, Fran Prenen, Chiara Varamo, Donatella Ponti, Ginevra Doglioni, Ana Margarida Ferreira Campos, Juan Fernandez Garcia, Silvia Radenkovic, Pegah Rouhi, Aleksandar Beatovic, Liwei Wang, Yu Wang, Amalia Tzoumpa, Asier Antoranz, Ara Sargsian, Mario Di Matteo, Emanuele Berardi, Jermaine Goveia, Bart Ghesquière, Tania Roskams, Stefaan Soenen, Thomas Voets, Bella Manshian, Sarah-Maria Fendt, Peter Carmeliet, Abhishek D. Garg, Ramanuj DasGupta, Baki Topal and Massimiliano Mazzone. https://www.nature.com/articles/s43018-024-00771-8
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress – Brian T. Do, Peggy P. Hsu, Sidney Y. Vermeulen. Zhishan Wang, Taghreed Hirz, Keene L. Abbott, Najihah Aziz, Joseph M. Replogle, Stefan Bjelosevic, Jonathan Paolino, Samantha A. Nelson, Samuel Block, Alicia M. Darnell, Raphael Ferreira, Hanyu Zhang, Jelena Milosevic, Daniel R. Schmidt, Christopher Chidley, Isaac S. Harris, Jonathan S. Weissman, Yana Pikman, Kimberly Stegmaier, Sihem Cheloufi, Xiaofeng A. Su, David B. Sykes, Matthew G. Vander Heiden. https://www.cell.com/developmental-cell/abstract/S1534-5807(24)00327-7
Cysteine / Glutathione
Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants – Chao Yang, Abhijeet Pataskar, Xiaodong Feng, Jasmine Montenegro Navarro, Inés Paniagua, Jacqueline J.L. Jacobs, Esther A. Zaal, Celia R. Berkers, Onno B. Bleijerveld, Reuven Agami. https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00327-7
Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC – Nathan P. Ward, Sang Jun Yoon, Tyce Flynn, Amanda M. Sherwood, Maddison A. Olley, Juliana Madej and Gina M. DeNicola. https://www.nature.com/articles/s41467-024-48695-2
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis – Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan and Albert C. Koong. https://www.nature.com/articles/s41467-024-48330-0
NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells – Laura Bottoni, Alberto Minetti, Giulia Realini, Elena Pio, Daniela Giustarini, Ranieri Rossi, Chiara Rocchio, Lorenzo Franci, Laura Salvini, Orazio Catona, Romina D’Aurizio, Mahdi Rasa, Emanuele Giurisato, Francesco Neri, Maurizio Orlandini, Mario Chiariello and Federico Galvagni. https://www.nature.com/articles/s41388-024-03025-0
Serine
ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis – Wensong Luo, Zizheng Zou, Yuan Nie, Junli Luo, Zhengnan Ming, Xiyuan Hu, Tiao Luo, Min Ouyang, Mingquan Liu, Huicheng Tang, Yuanzhu Xie, Kunjian Peng, Ling Chen, Jiang Zhou and Zhiyong Luo. https://www.nature.com/articles/s41419-024-06672-z
L-2-hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models – Anirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard Kirkman, Madhuparna Pandit, EunHee Shim, Hayley Widden, Juan Liu, Yasaman Heidarian, Nader H. Mahmoudzadeh, Alexander J. Fitt, Devin Absher, Han-Fei Ding, David K. Crossman, William J. Placzek, Jason W. Locasale, Dinesh Rakheja, Jonathan E. McConathy, Rekha Ramachandran, Sejong Bae, Jason M. Tennessen, Sunil Sudarshan. https://www.jci.org/articles/view/171294
Serine synthesis controls mitochondrial biogenesis in macrophages – Wang C, Zhao M, Bin P, Ye Y, Chen Q, Tang Z, Ren W. https://www.science.org/doi/10.1126/sciadv.adn2867
Other amino acids
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis – Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro, Yi-Heng Hao, Lizbeth Perez-Castro, Pedro A. S. Nogueira, Ashley Solmonson, Ilgen Mender, Jessica A. Kilgore, Shun Fang, Isabella N. Brown, Li Li, Emily Parks, Igor Lopes dos Santos, Mahima Bhaskar, Jiwoong Kim, Yuemeng Jia, Andrew Lemoff, Nick V. Grishin, Lisa Kinch, Lin Xu, Noelle S. Williams, Jerry W. Shay, Ralph J. DeBerardinis, Hao Zhu and Maralice Conacci-Sorrell. https://www.nature.com/articles/s41467-024-47868-3
Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies – Chiara Montironi, Zhenghao Chen, Ingrid A.M. Derks, Gaspard Cretenet, Esmée A. Krap, Eric Eldering, Helga Simon-Molas. https://www.sciencedirect.com/science/article/pii/S2589004224008629
Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma – Xing Jin, Lei Liu, Dan Liu, Jia Wu, Congcong Wang, Siliang Wang, Fengying Wang, Guanzhen Yu, Xiaoxia Jin, Yu-Wen Xue, Dan Jiang, Yan Ni, Xi Yang, Ming-Song Wang, Zhi-Wei Wang, Yuriy L. Orlov, Wei Jia, Gerry Melino, Ji-Bin Liu and Wen-Lian Chen. https://www.nature.com/articles/s41418-024-01285-7
Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions – Xindan Zhang, Zhenggang Zhao, Xuepeng Wang, Shiwei Zhang, Zilong Zhao, Wenbin Feng, Lijun Xu, Junhua Nie, Hong Li, Jia Liu, Gengmiao Xiao, Yu Zhang, Haomiao Li, Ming Lu, Jialuo Mai, Sujin Zhou, Allan Z. Zhao and Fanghong Li. https://www.nature.com/articles/s41419-024-06727-1
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma – Najla El-Hachem, Marine Leclercq, Miguel Susaeta Ruiz, Raphael Vanleyssem, Kateryna Shostak, Pierre-René Körner, Coralie Capron, Lorena Martin-Morales, Patrick Roncarati, Arnaud Lavergne, Arnaud Blomme, Silvia Turchetto, Eric Goffin, Palaniraja Thandapani, Ivan Tarassov, Laurent Nguyen, Bernard Pirotte, Alain Chariot, Jean-Christophe Marine, Michael Herfs, Francesca Rapino, Reuven Agami and Pierre Close. https://www.nature.com/articles/s41556-024-01439-2
Lipids, acetate
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc – Juhong Wang, Yannan Yang, Fei Shao, Ying Meng, Dong Guo, Jie He and Zhimin Lu. https://www.nature.com/articles/s42255-024-01037-4
STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth – Yunzhou Fan, Rui Zhang, Chao Wang, Meixia Pan, Feng Geng, Yaogang Zhong, Huali Su, Yongjun Kou, Xiaokui Mo, Etienne Lefai, Xianlin Han, Arnab Chakravarti, Deliang Guo. https://www.jbc.org/article/S0021-9258(24)01852-0/fulltext
Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions – Jonathan M. Alektiar , Mengrou Shan , Megan D. Radyk,Li Zhang, Christopher J. Halbrook, Lin Lin, Carlos Espinoza, Ivan F. Mier, Brooke L. Lavoie, Lucie Salvatore, Marina Pasca di Magliano, Lewis C. Cantley, Jacob L. Mueller, Costas A. Lyssiotis. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303577
Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma – Romain Riscal, Sarah M. Gardner, Nathan J. Coffey, Madeleine Carens, Clementina Mesaros, Jimmy P. Xu, Yizheng Xue, Leah Davis, Sara Demczyszyn, Austin Vogt, Adam Olia, Jennifer M. Finan, Jason Godfrey, David C. Schultz, Ian A. Blair, Brian Keith, Ronen Marmorstein, Nicolas Skuli, M. Celeste Simon. https://aacrjournals.org/cancerres/article-abstract/84/10/1570/745316
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer – Ningning Niu, Xuqing Shen, Zheng Wang, Yueyue Chen, Yawen Weng, Feier Yu, Yingying Tang, Ping Lu, Mingzhu Liu, Liwei Wang, Yongwei Sun, Minwei Yang, Baiyong Shen, Jiabin Jin, Zipeng Lu, Kuirong Jiang, Yufeng Shi, Jing Xue. https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00090-4
SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma – Rongrong Fu, Wenqing Xue, Jingjie Liang, Xinran Li, Juan Zheng, Lechen Wang, Min Zhang and Jing Meng. https://www.nature.com/articles/s41419-024-06711-9
Mitochondria
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers – Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R. Marszalek, Masha V. Poyurovsky, Kellen Olszewski, Boyi Gan. https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00324-1
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity – Alaa Al Assi, Solène Posty, Frédéric Lamarche, Amel Chebel, Jérôme Guitton, Cécile Cottet-Rousselle, Renaud Prudent, Laurence Lafanechère, Stéphane Giraud, Patrick Dallemagne, Peggy Suzanne, Aurélie Verney, Laurent Genestier, Marie Castets, Eric Fontaine, Marc Billaud and Martine Cordier-Bussat. https://www.nature.com/articles/s41419-024-06668-9
OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition – Yabing Nan, Xiaowei Wu, Qingyu Luo, Wan Chang, Pengfei Zhao, Lingqiang Zhang and Zhihua Liu. https://www.pnas.org/doi/10.1073/pnas.2315348121
Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain – Francesco Agostini, Leonardo Pereyra, Justin Dale, King Faisal Yambire, Silvia Maglioni, Alfonso Schiavi, Natascia Ventura, Ira Milosevic, Nuno Raimundo. https://www.jbc.org/article/S0021-9258(24)01904-5/fulltext
Starvation, metabolic stress
Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response – Chen Lior, Debra Barki, Coral Halperin, Christine A. Iacobuzio-Donahue, David Kelsen, Ruth Scherz- Shouval. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00564-3
Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity – Arin Nam, Shashi Jain, Chengsheng Wu, Alejandro Campos, Ryan M. Shepard, Ziqi Yu, Joshua P. Reddy, Tami Von Schalscha, Sara M. Weis, Mark Onaitis, Hiromi I. Wettersten, David A. Cheresh. https://doi.org/10.1158/0008-5472.CAN-23-2700
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis – Jingjing Luo, Yang Yang, Guang Zhang, Debao Fang, Kaiyue Liu, Yide Mei and Fang Wang. https://www.nature.com/articles/s41419-024-06743-1
mTOR
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism – Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat and Gabriel Leprivier. https://www.nature.com/articles/s41467-024-48386-y
A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan – Ana Ortega-Molina, Cristina Lebrero-Fernández, Alba Sanz, Miguel Calvo-Rubio, Nerea Deleyto-Seldas, Lucía de Prado-Rivas, Ana Belén Plata-Gómez, Elena Fernández-Florido, Patricia González-García, Yurena Vivas-García, Elena Sánchez García, Osvaldo Graña-Castro, Nathan L. Price, Alejandra Aroca-Crevillén, Eduardo Caleiras, Daniel Monleón, Consuelo Borrás, María Casanova-Acebes, Rafael de Cabo and Alejo Efeyan. https://www.nature.com/articles/s43587-024-00635-x
Hypoxia
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells – Joycelyn Tan, Sam Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry JM Baird, James A Horscroft, Alice P Sowton, Marcella Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley. https://www.embopress.org/doi/full/10.1038/s44318-024-00084-7
IDH
Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma – Avishay Spitzer, Simon Gritsch, Masashi Nomura, Alexander Jucht, Jerome Fortin, Ramya Raviram, Hannah R. Weisman, L. Nicolas Gonzalez Castro, Nicholas Druck, Rony Chanoch-Myers, John J.Y. Lee, Ravindra Mylvaganam, Rachel Lee Servis, Jeremy Man Fung, Christine K. Lee, Hiroaki Nagashima, Julie J. Miller, Isabel Arrillaga-Romany, David N. Louis, Hiroaki Wakimoto, Will Pisano, Patrick Y. Wen, Tak W. Mak, Marc Sanson, Mehdi Touat, Dan A. Landau, Keith L. Ligon, Daniel P. Cahill, Mario L. Suvà, Itay Tirosh. https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00093-X
Cancer Immunometabolism
C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells – Ma EH, Dahabieh MS, DeCamp LM, Kaymak I, Kitchen-Goosen SM, Roy DG, Verway MJ, Johnson RM, Samborska B, Scullion CA, Steadman M, Vos M, Roddy TP, Krawczyk CM, Williams KS, Sheldon RD, Jones RG. https://www.science.org/doi/10.1126/sciadv.adj1431
25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages – Jun Xiao, Shuang Wang, Longlong Chen, Xinyu Ding, Yuanhao Dang, Mingshun Han, Yuxiao Zheng, Huan Shen, Sifan Wu, Mingchang Wang, Dan Yang, Na Li, Chen Dong, Miao Hu, Chen Su, Weiyun Li, Lijian Hui, Youqiong Ye, Huiru Tang, Bin Wei, Hongyan Wang. https://www.cell.com/immunity/abstract/S1074-7613(24)00142-0
Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma – Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu, Fabio Scirocchi, Delia Scocozza, Barbara Peixoto, Angelica Pace, Luca D’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Filippo Veglia. https://www.cell.com/immunity/abstract/S1074-7613(24)00211-5
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression – Plebanek MP, Xue Y, Nguyen YV, DeVito NC, Wang X, Holtzhausen A, Beasley GM, Theivanthiran B, Hanks BA. https://www.science.org/doi/10.1126/sciimmunol.adi4191
Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment – Elizabeth G. Hunt, Katie E. Hurst, Brian P. Riesenberg, Andrew S. Kennedy, Evelyn J. Gandy, Alex M. Andrews, Coral del Mar Alicea Pauneto, Lauren E. Ball, Emily D. Wallace, Peng Gao, Jeremy Meier, John J. Serody, Michael F. Coleman, Jessica E. Thaxton. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00055-X
Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy – Xinyu Tang, Xinrui Mao, Peiwen Ling, Muxin Yu, Hua Pan, Jiaming Wang, Mingduo Liu, Hong Pan, Wen Qiu, Nan Che, Kai Zhang, Feifan Bao, Hongwei Peng, Qiang Ding, Shui Wang and Wenbin Zhou. https://www.nature.com/articles/s41467-024-49059-6
Glucose metabolism, glycolytic enzymes
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis – Zhi Zong, Feng Xie, Shuai Wang, Xiaojin Wu, Zhenyu Zhang, Bing Yang, Fangfang Zhou. https://www.cell.com/cell/abstract/S0092-8674(24)00397-0
The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells – Pauline de Zeeuw, Lucas Treps, Melissa García-Caballero, Ulrike Harjes, Joanna Kalucka, Carla De Legher, Katleen Brepoels, Kristel Peeters, Stefan Vinckier, Joris Souffreau, Ann Bouché, Federico Taverna, Jonas Dehairs, Ali Talebi, Bart Ghesquière, Johan Swinnen, Luc Schoonjans, Guy Eelen, Mieke Dewerchin and Peter Carmeliet. https://www.nature.com/articles/s42003-024-06186-6
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma – Yuanli Zhen, Kai Liu, Lei Shi, Simran Shah, Qin Xu, Haley Ellis, Eranga R. Balasooriya, Johannes Kreuzer, Robert Morris, Albert S. Baldwin, Dejan Juric, Wilhelm Haas and Nabeel Bardeesy. https://www.nature.com/articles/s41467-024-47514-y
Diet, systemic metabolism and cachexia
The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia – Mingyang Liu, Yu Ren, Zhijun Zhou, Jingxuan Yang, Xiuhui Shi, Yang Cai, Alex X. Arreola, Wenyi Luo, Kar-Ming Fung, Chao Xu, Ryan D. Nipp, Michael S. Bronze, Lei Zheng, Yi-Ping Li, Courtney W. Houchen, Yuqing Zhang, Min Li. https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00094-1
Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy – Sean Murphy, Sharif Rahmy, Dailin Gan, Guoqiang Liu, Yini Zhu, Maxim Manyak, Loan Duong, Jianping He, James H. Schofield, Zachary T. Schafer, Jun Li, Xuemin Lu, Xin Lu. https://aacrjournals.org/cancerres/article-abstract/84/10/1597/745315
Ketogenic diet induces p53-dependent cellular senescence in multiple organs – Wei SJ, Schell JR, Chocron ES, Varmazyad M, Xu G, Chen WH, Martinez GM, Dong FF, Sreenivas P, Trevino R Jr, Jiang H, Du Y, Saliba A, Qian W, Lorenzana B, Nazarullah A, Chang J, Sharma K, Munkácsy E, Horikoshi N, Gius D. https://www.science.org/doi/10.1126/sciadv.ado1463
Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer – Henning Tim Langer, Shakti Ramsamooj, Ezequiel Dantas, Anirudh Murthy, Mujmmail Ahmed, Tanvir Ahmed, Seo-Kyoung Hwang, Rahul Grover, Rita Pozovskiy, Roger J. Liang, Andre Lima Queiroz, Justin C. Brown, Eileen P. White, Tobias Janowitz, Marcus D. Goncalves. https://onlinelibrary.wiley.com/doi/10.1111/apha.14167
Area postrema neurons mediate interleukin-6 function in cancer cachexia – Qingtao Sun, Daniëlle van de Lisdonk, Miriam Ferrer, Bruno Gegenhuber, Melody Wu, Youngkyu Park, David A. Tuveson, Jessica Tollkuhn, Tobias Janowitz and Bo Li. https://www.nature.com/articles/s41467-024-48971-1
Miscellaneous
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments – Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden and Peter K. Sorger. https://www.nature.com/articles/s41556-024-01402-1
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability – Mariko Takahashi, Harrison B. Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J. Lazarov, Stefan Harry, Michelle Maynard, Brendan Hilbert, Ryan D. White, Heather E. Murrey, Chih-Chiang Tsou, Kira Vordermark, Jonathan Assaad, Magdy Gohar, Benedikt R. Dürr, Marianne Richter, Himani Patel, Gregory Kryukov, Natasja Brooijmans, Aliyu Sidi Omar Alghali, Karla Rubio, Antonio Villanueva, Junbing Zhang, Maolin Ge, Farah Makram, Hanna Griesshaber, Drew Harrison, Ann-Sophie Koglin, Samuel Ojeda, Barbara Karakyriakou, Alexander Healy, George Popoola, Inbal Rachmin, Neha Khandelwal, Jason R. Neil, Pei-Chieh Tien, Nicholas Chen, Tobias Hosp, Sanne van den Ouweland, Toshiro Hara, Lillian Bussema, Rui Dong, Lei Shi, Martin Q. Rasmussen, Ana Carolina Domingues, Aleigha Lawless, Jacy Fang, Satoshi Yoda, Linh Phuong Nguyen, Sarah Marie Reeves, Farrah Nicole Wakefield, Adam Acker, Sarah Elizabeth Clark, Taronish Dubash, John Kastanos, Eugene Oh, David E. Fisher, Shyamala Maheswaran, Daniel A. Haber, Genevieve M. Boland, Moshe Sade-Feldman, Russell W. Jenkins, Aaron N. Hata, Nabeel M. Bardeesy, Mario L. Suvà, Brent R. Martin, Brian B. Liau, Christopher J. Ott, Miguel N. Rivera, Michael S. Lawrence, Liron Bar-Peled. https://www.cell.com/cell/abstract/S0092-8674(24)00318-0
iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP – Jonathan S. Marvin, Alexandros C. Kokotos, Mukesh Kumar, Camila Pulido, Ariana N. Tkachuk, Jocelyn Shuxin Yao, Timothy A. Brown and Timothy A. Ryan. https://www.pnas.org/doi/10.1073/pnas.2314604121
Reviews
Cycling back to folate metabolism in cancer – Younghwan Lee, Karen H. Vousden and Marc Hennequart. https://www.nature.com/articles/s43018-024-00739-8
Amino acid transporters within the solute carrier superfamily: Underappreciated proteins and novel opportunities for cancer therapy – Kiavash Hushmandi, Behzad Einollahi, Seyed Hassan Saadat, E. Hui Clarissa Lee, Marzieh Ramezani Farani, Elena Okina, Yun Suk Huh, Noushin Nabavi, Shokooh Salimimoghadam, Alan Prem Kumar. https://www.sciencedirect.com/science/article/pii/S2212877824000838
Metabolite‐derived damage‐associated molecular patterns in immunological diseases – Na Kang, Zhenglin Ji, Yuxin Li, Ji Gao, Xinfeng Wu, Xiaoyang Zhang, Qinghui Duan, Can Zhu, Yue Xu, Luyao Wen, Xiaofei Shi, Wanli Liu. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16902?campaign=woletoc
Exploring the diverse role of pyruvate kinase M2 in cancer: Navigating beyond glycolysis and the Warburg effect – Saurabh Upadhyay, Shumayila Khan, Md. Imtaiyaz Hassan. https://www.sciencedirect.com/science/article/abs/pii/S0304419X24000209
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors – Yosuke Kitagawa, Ami Kobayashi, Daniel P. Cahill, Hiroaki Wakimoto, Shota Tanaka. https://www.sciencedirect.com/science/article/abs/pii/S0304419X24000337
Adipose tissue rearrangement in cancer cachexia: The involvement of β3-adrenergic receptor associated pathways – Inês N.R. Mota, Setareh Satari, Inês Soares Marques, Joana M.O. Santos, Rui Medeiros. https://www.sciencedirect.com/science/article/abs/pii/S0304419X24000349
Comments
Oxygen shortage: Himalayan adventures in an incubator – Nathalie M Mazure. https://www.embopress.org/doi/full/10.1038/s44318-024-00105-5
Overcoming Nutrient Stress: Integrin αvβ3-Driven Metabolic Adaptation Supports Tumor Initiation – Elena Rainero. https://aacrjournals.org/cancerres/article-abstract/84/10/1543/745305
The lactate wasteland – Wei Wong. https://www.science.org/doi/10.1126/scisignal.adq3321
Cysteine substitutants emerge in lung cancer proteomes during arginine restriction – Dennis J. Hsu, Sohail F. Tavazoie. https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00384-8
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses – Qiang Cai, Yihao Tian, Quazi T.H. Shubhra. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00127-X
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer – Shane J.F. Cronin. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00129-3
Shifting the landscape: The role of IDH inhibitors in glioma cell fate – Skylar A. Giacobetti, Howard A. Fine. https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00052-7
Metabolism and Cancer articles 