mTOR
Structural basis for the docking of mTORC1 on the lysosomal surface – Kacper B. Rogala, Xin Gu, Jibril F. Kedir, Monther Abu-Remaileh, Laura F. Bianchi, Alexia M. S. Bottino, Rikke Dueholm, Anna Niehaus, Daan Overwijn, Ange-Célia Priso Fils, Sherry X. Zhou, Daniel Leary, Nouf N. Laqtom, Edward J. Brignole, David M. Sabatini. https://science.sciencemag.org/content/366/6464/468
Architecture of human Rag GTPase heterodimers and their complex with mTORC1 – Madhanagopal Anandapadamanaban, Glenn R. Masson, Olga Perisic, Alex Berndt, Jonathan Kaufman, Chris M. Johnson, Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Roger L. Williams. https://science.sciencemag.org/content/366/6462/203
mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux – Florian Beaumatin, Jim O’Prey, Valentin J.A. Barthet, Barbara Zunino, Jean-Philippe Parvy, Alexis Maximilien Bachmann, Margaret O’Prey, Elżbieta Kania, Pablo Sierra Gonzalez, Robin Macintosh, Laurence Y. Lao, Colin Nixon, Jonathan Lopez, Jaclyn S. Long, Stephen W.G. Tait, Kevin M. Ryan. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30551-9
Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1 – Eugènia Almacellas, Joffrey Pelletier, Anna Manzano, Antonio Gentilella, Santiago Ambrosio, Caroline Mauvezin, Albert Tauler. https://www.cell.com/iscience/fulltext/S2589-0042(19)30379-7
Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment – Brittany Angarola and Shawn M. Ferguson. https://www.molbiolcell.org/doi/10.1091/mbc.E19-03-0146?ai=s5&ui=2oy6&af=T
The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast – Sophie Reidman, Adiel Cohen, Martin Kupiec and Ronit Weisman. http://www.jbc.org/content/early/2019/10/22/jbc.RA119.010101.abstract
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival – Laia Martínez-Carreres, Julien Puyal, Lucía C. Leal-Esteban, Meritxell Orpinell, Judit Castillo-Armengol, Albert Giralt, Oleksandr Dergai, Catherine Moret, Valentin Barquissau, Anita Nasrallah, Angélique Pabois, Lianjun Zhang, Pedro Romero, Isabel C. Lopez-Mejia and Lluis Fajas. https://cancerres.aacrjournals.org/content/79/20/5245
Starvation / nutrient sensing
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development – Xiongjun Wang, Ruilong Liu, Xiujuan Qu, Hua Yu, Huiying Chu, Yajuan Zhang, Wencheng Zhu, Xueyuan Wu, Hong Gao, Bangbao Tao, Wenfeng Li, Ji Liang, Guohui Li, Weiwei Yang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30537-4
Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast – Fan Zheng, Bowen Jia, Fenfen Dong, Ling Liu, Faiz Rasul, Jiajia He and Chuanhai Fu. http://www.jbc.org/content/early/2019/09/27/jbc.RA119.010185.abstract
Phosphorylation of Arabidopsis eIF4E and eIFiso4E by SnRK1 inhibits translation – Aaron N. Bruns, Sizhun Li, Gireesha Mohannath, David M. Bisaro. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14935
ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing – Roland Imle, Bei-Tzu Wang, Nicolas Stützenberger, Jana Birkenhagen, Amol Tandon, Matthias Carl, Nastassja Himmelreich, Christian Thiel, Hermann-Josef Gröne, Gernot Poschet, Mirko Völkers, Karsten Gülow, Anne Schröder, Sara Carillo, Stefan Mittermayr, Jonathan Bones, Marcin Mikołaj Kamiński, Stefan Kölker and Sven Wolfgang Sauer. https://www.nature.com/articles/s41598-019-50566-6
The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing – Travis B. Lear, Karina C. Lockwood, Yurong Ouyang, John W. Evankovich, Mads B. Larsen, Bo Lin, Yuan Liu and Bill B. Chen. http://www.jbc.org/content/early/2019/10/04/jbc.AC119.010671.abstract
AMPK
Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells – Karin Bartel, Rolf Müller and Karin von Schwarzenberg. http://www.jbc.org/content/early/2019/10/11/jbc.RA119.010243.abstract
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC – Pablo E. Hollstein, Lillian J. Eichner, Sonja N. Brun, Anwesh Kamireddy, Robert U. Svensson, Liliana I. Vera, Debbie S. Ross, T.J. Rymoff, Amanda Hutchins, Hector M. Galvez, April E. Williams, Maxim N. Shokhirev, Robert A. Screaton, Rebecca Berdeaux and Reuben J. Shaw. https://cancerdiscovery.aacrjournals.org/content/9/11/1606
Glucose / lactate
Metabolic regulation of gene expression by histone lactylation – Di Zhang, Zhanyun Tang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel Czyz, Rong Hu, Zhen Ye, Maomao He, Y. George Zheng, Howard A. Shuman, Lunzhi Dai, Bing Ren, Robert G. Roeder, Lev Becker and Yingming Zhao. https://www.nature.com/articles/s41586-019-1678-1
Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays – Jun O. Liu, Zufeng Guo, Zhiqiang Cheng, Jingxin Wang, Wukun Liu, Hanjing Peng, Yuefan Wang, Subba Rao, Ruojing Li, Xue Ying, Preethi Korangath, Maria Liberti, Yingjun Li, Yongmei Xie, Sam Hong, Cordelia Schiene-Fischer, Gunter Fischer, Jason Locasale, Saraswati Sukumar, Heng Zhu. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201905578
Near-equilibrium glycolysis supports metabolic homeostasis and energy yield – Junyoung O. Park, Lukas B. Tanner, Monica H. Wei, Daven B. Khana, Tyler B. Jacobson, Zheyun Zhang, Sara A. Rubin, Sophia Hsin-Jung Li, Meytal B. Higgins, David M. Stevenson, Daniel Amador-Noguez and Joshua D. Rabinowitz. https://www.nature.com/articles/s41589-019-0364-9
Hexosamines / gluconeogenesis
Inhibiting the hexosamine biosynthetic pathway lowers O-GlcNAcylation levels and sensitizes cancer to environmental stress – Lisa A Walter, Yu Hsuan Lin, Christopher J Halbrook, Kelly N Chuh, Lina He, Nichole J Pedowitz, Anna R Batt, Caroline K Brennan, Bangyan L. Stiles, Costas Andreas Lyssiotis, Matthew R. Pratt. https://pubs.acs.org/doi/abs/10.1021/acs.biochem.9b00560#
The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability – Vineeth Vengayil, Zeenat Rashida and Sunil Laxman. http://www.jbc.org/content/early/2019/10/11/jbc.RA119.009822.abstract
Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer – Chatchadawalai Chokchaitaweesuk, Takashi Kobayashi, Tomomi Izumikawa and Naoki Itano. https://www.nature.com/articles/s41419-019-2034-y
Cystine / Glutathione / ROS
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation – Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB. https://www.sciencedirect.com/science/article/abs/pii/S1550413119305121
Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma – Frauke Goeman, Francesca De Nicola, Stefano Scalera, Francesca Sperati, Enzo Gallo, Ludovica Ciuffreda, Matteo Pallocca, Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Patrizia Vici, Maddalena Barba, Simonetta Buglioni, Beatrice Casini, Paolo Visca, Edoardo Pescarmona, Marco Mazzotta, Ruggero De Maria, Maurizio Fanciulli, Gennaro Ciliberto, Marcello Maugeri-Saccà. https://www.jto.org/article/S1556-0864(19)30560-X/fulltext
Other amino acids
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism – Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31244-6
CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression – Sara Cano-Crespo, Josep Chillarón, Alexandra Junza, Gonzalo Fernández-Miranda, Judit García, Christine Polte, Laura R. de la Ballina, Zoya Ignatova, Óscar Yanes, Antonio Zorzano, Camille Stephan-Otto Attolini and Manuel Palacín. https://www.nature.com/articles/s41598-019-50547-9
Promoter demethylation of the asparagine synthetase gene is required for an ATF4-dependent adaptation to asparagine depletion – Jie Jiang, Sankalp Srivastava, Gretchen Seim, Natalya N Pavlova, Bryan King, Lihua Zou, Chi Zhang, Minghua Zhong, Hui Feng, Reuben Kapur, Ronald C. Wek, Jing Fan and Ji Zhang. http://www.jbc.org/content/early/2019/10/28/jbc.RA119.010447.abstract
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation – Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, Rachael Natrajan, Eric S. Christenson, Barbara Roman, Samarjit Das, Liang Zhao, Robert D. Leone, Daniel Shinn, Taylor Groginski, Anil K. Madugundu, Arun Patil, Daniel J. Zabransky, Arielle Medford, Justin Lee, Alex J. Cole, Marc Rosen, Maya Thakar, Alexander Ambinder, Joshua Donaldson, Amy E. DeZern, Karen Cravero, David Chu, Rafael Madero-Marroquin, Akhilesh Pandey, Paula J. Hurley, Josh Lauring and Ben Ho Park. https://www.jci.org/articles/view/125022
Nucleotides
Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers – Aarif Siddiqui, Paradesi Naidu Gollavilli, Annemarie Schwab, Maria Eleni Vazakidou, Pelin G. Ersan, Mallika Ramakrishnan, Dick Pluim, Si’Ana Coggins, Ozge Saatci, Laura Annaratone, Jan HM Schellens, Baek Kim, Irfan Ahmed Asangani, Suhail Ahmed Kabeer Rasheed, Caterina Marchiò, Ozgur Sahin and Paolo Ceppi. https://www.nature.com/articles/s41418-019-0289-6
Mitochondria
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer – Milica Momcilovic, Anthony Jones, Sean T. Bailey, Christopher M. Waldmann, Rui Li, Jason T. Lee, Gihad Abdelhady, Adrian Gomez, Travis Holloway, Ernst Schmid, David Stout, Michael C. Fishbein, Linsey Stiles, Deepa V. Dabir, Steven M. Dubinett, Heather Christofk, Orian Shirihai, Carla M. Koehler, Saman Sadeghi and David B. Shackelford. https://www.nature.com/articles/s41586-019-1715-0
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies – Romain Guièze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández-Sánchez, Aina Martinez Zurita, Jing Sun, Elisa Ten Hacken, Kaitlyn Baranowski, Philip A. Thompson, Jin-Mi Heo, Zachary Cartun, Ozan Aygün, J. Bryan Iorgulescu, Wandi Zhang, Giulia Notarangelo, Dimitri Livitz, Shuqiang Li, Matthew S. Davids, Anat Biran, Stacey M. Fernandes, Jennifer R. Brown, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, Derin B. Keskin, Namrata D. Udeshi, William G. Wierda, Kenneth J. Livak, Anthony G. Letai, Donna Neuberg, J. Wade Harper, Steven A. Carr, Federica Piccioni, Christopher J. Ott, Ignaty Leshchiner, Cory M. Johannessen, John Doench, Vamsi K. Mootha, Gad Getz, Catherine J. Wu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30373-3
The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II – Hye-Young Min, Hyun-Ji Jang, Kwan Hee Park, Seung Yeob Hyun, So Jung Park, Ji Hye Kim, Jaekyoung Son, Sam Sik Kang and Ho-Young Lee. https://www.nature.com/articles/s41419-019-2041-z
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response – David Sharon, Severine Cathelin, Sara Mirali, Justin M. Di Trani, David J. Yanofsky, Kristine A. Keon, John L. Rubinstein, Aaron D. Schimmer, Troy Ketela and Steven M. Chan. https://stm.sciencemag.org/content/11/516/eaax2863
Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats – Min Hee Lee, Ralph J. DeBerardinis, Xiaodong Wen, Ian R.Corbin, A. Dean Sherry, Craig R. Malloy, Eunsook S.Jin. https://www.sciencedirect.com/science/article/abs/pii/S0026049519302082
Hypoxia
Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells – Ke Tang, Yuandong Yu, Liyan Zhu, Pingwei Xu, Jie Chen, Jingwei Ma, Huafeng Zhang, Haiqing Fang, Weiwei Sun, Li Zhou, Keke Wei, Fei Li, Jiadi Lv, Jing Xie, Yuying Liu and Bo Huang. https://www.nature.com/articles/s41388-019-0932-1
Effect of hypoxia on human equilibrative nucleoside transporters hENT1 and hENT2 in breast cancer – Daniel Krys, Ingrit Hamann, Melinda Wuest and Frank Wuest. https://www.fasebj.org/doi/abs/10.1096/fj.201900870RR
Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma – Jinkyu Jung, Ying Zhang, Orieta Celiku, Wei Zhang, Hua Song, Brian J. Williams, Amber J. Giles, Jeremy N. Rich, Roger Abounader, Mark R. Gilbert and Deric M. Park. https://cancerres.aacrjournals.org/content/79/20/5218
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression – Yulin Shi, Songqing Fan, Mengge Wu, Zhixiang Zuo, Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu, Lin Zeng, Yongchun Zhou, Yunchao Huang, Zuozhang Yang, Jumin Zhou, Jing Gao, Hu Zhou, Shuhua Xu, Hongbin Ji, Peng Shi, Dong-Dong Wu, Cuiping Yang and Yongbin Chen. https://www.nature.com/articles/s41467-019-12801-6
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species – Hilary E. Nicholson , Zeshan Tariq, Benjamin E. Housden, Rebecca B. Jennings, Laura A. Stransky, Norbert Perrimon, Sabina Signoretti, William G. Kaelin Jr. https://stke.sciencemag.org/content/12/601/eaay0482
IDH
Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma – Makoto Nakagawa, Fumihiko Nakatani, Hironori Matsunaga, Takahiko Seki, Makoto Endo, Yoko Ogawara, Yukino Machida, Takuo Katsumoto, Kazutsune Yamagata, Ayuna Hattori, Shuhei Fujita, Yukiko Aikawa, Takamasa Ishikawa, Tomoyoshi Soga, Akira Kawai, Hirokazu Chuman, Nobuhiko Yokoyama, Suguru Fukushima, Kenichiro Yahiro, Atsushi Kimura, Eijiro Shimada, Takeshi Hirose, Toshifumi Fujiwara, Nokitaka Setsu, Yoshihiro Matsumoto, Yukihide Iwamoto, Yasuharu Nakashima and Issay Kitabayashi. https://www.nature.com/articles/s41388-019-0929-9
The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis – Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan and Hai-Xin Yuan. https://www.nature.com/articles/s41419-019-1984-4
Increased 14C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with 11C-acetate PET imaging – Koyasu S, Shimizu Y, Morinibu A, Saga T, Nakamoto Y, Togashi K, Harada H. https://link.springer.com/article/10.1007%2Fs11060-019-03322-9
Miscellaneous
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy – Marin L. Gantner, Kevin Eade, […], Christian M. Metallo and Martin Friedlander. https://www.nejm.org/doi/full/10.1056/NEJMoa1815111
Structural basis of species-selective antagonist binding to the succinate receptor – Matthias Haffke, Dominique Fehlmann, Gabriele Rummel, Jacques Boivineau, Myriam Duckely, Nina Gommermann, Simona Cotesta, Finton Sirockin, Felix Freuler, Amanda Littlewood-Evans, Klemens Kaupmann and Veli-Pekka Jaakola. https://www.nature.com/articles/s41586-019-1663-8
Reviews
A framework for examining how diet impacts tumour metabolism – Evan C. Lien and Matthew G. Vander Heiden. https://www.nature.com/articles/s41568-019-0198-5
Methionine metabolism in health and cancer: a nexus of diet and precision medicine – Sydney M. Sanderson, Xia Gao, Ziwei Dai and Jason W. Locasale. https://www.nature.com/articles/s41568-019-0187-8
The metabolic engine of endothelial cells – Kim D. Falkenberg, Katerina Rohlenova, Yonglun Luo and Peter Carmeliet. https://www.sciencedirect.com/science/article/abs/pii/S1567724919301394
Oncometabolites in renal cancer – Cissy Yong, Grant D. Stewart and Christian Frezza. https://www.nature.com/articles/s41581-019-0210-z
Growth Factors Stimulate Anabolic Metabolism by Directing Nutrient Uptake – Craig B. Thompson and Agata A. Bielska. http://www.jbc.org/content/early/2019/10/18/jbc.AW119.008146.abstract
Mitochondria orchestrate proteostatic and metabolic stress responses – Claes Andréasson, Martin Ott, Sabrina Büttner. https://www.embopress.org/doi/full/10.15252/embr.201947865
Even Cancer Cells Watch Their Cholesterol! – Romain Riscal, Nicolas Skuli, M. Celeste Simon. https://www.sciencedirect.com/science/article/abs/pii/S1097276519306938
Metabolic dependencies and vulnerabilities in leukemia – Marissa Rashkovan and Adolfo Ferrando. http://genesdev.cshlp.org/content/33/21-22/1460.abstract?etoc
Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease – Shijia Huang, Yuying Xing and Yong Liu. http://www.jbc.org/content/early/2019/10/30/jbc.REV119.007036.abstract
Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function – Xiaozhen Dai, Xiaoqing Yan, Kupper A. Wintergerst, Lu Cai, Bradley B. Keller, Yi Tan. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30246-1
The Rise of Physiologic Media – Jason R. Cantor. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30145-X
Comments
Histone lactylation links metabolism and gene regulation – Luke T. Izzo, Kathryn E. Wellen. https://www.nature.com/articles/d41586-019-03122-1
Metabolic vulnerability in tumours illuminated – Aparna D. Rao and Ralph J. DeBerardinis. https://www.nature.com/articles/d41586-019-03239-3
Mutations in the Antioxidant KEAP1/NRF2 Pathway Define an Aggressive Subset of NSCLC Resistant to Conventional Treatments – Ernest Nadal, Ramon Palmero, Cristina Muñoz-Pinedo. https://www.jto.org/article/S1556-0864(19)30672-0/fulltext
Suppressed fate [alpha-KG] – Anna Dart. https://www.nature.com/articles/s41568-019-0215-8
Arkaitz Carracedo: If the scientific question is good, the result will be interesting – Houston S. http://jem.rupress.org/content/early/2019/10/14/jem.20191880.long
Metabolism and Cancer articles 