Systemic metabolism and cancer
Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity – Mualla Ozcan, Zhen Guo, Carla Valenzuela Ripoll, Ahmed Diab, Antonino Picataggi, David Rawnsley, Aynaz Lotfinaghsh, Carmen Bergom, Jeff Szymanski, Daniel Hwang, Aarti Asnani, Mikhail Kosiborod, Jie Zheng, Robert J. Hayashi, Pamela K. Woodard, Attila Kovacs, Kenneth B. Margulies, Joel Schilling, Babak Razani, Abhinav Diwan, Ali Javaheri. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00042-6
Tumour extracellular vesicles and particles induce liver metabolic dysfunction – Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang and David Lyden. https://www.nature.com/articles/s41586-023-06114-4
Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status – Alexandra Chovsepian, Olga Prokopchuk, Gabriela Petrova, Tefta Gjini, Hanna Kuzi, Simone Heisz, Klaus-Peter Janssen, Marc E. Martignoni, Helmut Friess, Hans Hauner, Maria Rohm. https://www.sciencedirect.com/science/article/pii/S2212877823000637
Obesity and breast cancer prognosis: pre-diagnostic anthropometric measures in relation to patient, tumor, and treatment characteristics – Sixten Harborg, Maria Feldt, Deirdre Cronin-Fenton, Marie Klintman, Susanne O. Dalton, Ann H. Rosendahl and Signe Borgquist. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-023-00308-0
Glucose metabolism
Increased glucose availability sensitizes pancreatic cancer to chemotherapy – Ali Vaziri-Gohar, Jonathan J. Hue, Ata Abbas, Hallie J. Graor, Omid Hajihassani, Mehrdad Zarei, George Titomihelakis, John Feczko, Moeez Rathore, Sylwia Chelstowska, Alexander W. Loftus, Rui Wang, Mahsa Zarei, Maryam Goudarzi, Renliang Zhang, Belinda Willard, Li Zhang, Adam Kresak, Joseph E. Willis, Gi-Ming Wang, Curtis Tatsuoka, Joseph M. Salvino, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Jonathan R. Brody and Jordan M. Winter. https://www.nature.com/articles/s41467-023-38921-8
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness – Li Gu, Yahui Zhu, Kosuke Watari, Maiya Lee, Junlai Liu, Sofia Perez, Melinda Thai, Joshua E. Mayfield, Bichen Zhang, Karina Cunha e Rocha, Fuming Li, Laura C. Kim, Alexander C. Jones, Igor H. Wierzbicki, Xiao Liu, Alexandra C. Newton, Tatiana Kisseleva, Jun Hee Lee, Wei Ying, David J. Gonzalez, Alan R. Saltiel, M. Celeste Simon, Michael Karin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00126-2
Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling – Nevraj S Kejiou, Lena Ilan, Stefan Aigner, Enching Luo, Tori Tonn, Hakan Ozadam, Muyoung Lee, Gregory B Cole, Ines Rabano, Nishani Rajakulendran, Brian A Yee, Hamed S Najafabadi, Trevor F Moraes, Stephane Angers, Gene W Yeo, Can Cenik, Alexander F Palazzo. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad440/7177888
PKM2 controls the translation of TFE3 to maintain the integrity of the Golgi apparatus for the survival of HeLa and ME‐180 cervical cancer cells – Yuki Taguchi, Kengo Ito, Fumi Kano. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16740
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression – Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, and Ni Tang. https://www.jci.org/articles/view/161713
Cystine / Glutathione / Redox
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells – Yuelong Yan, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber Horbath, Xiaoguang Liu, Chao Mao, Shiqi Wu, Li Zhuang, M. James You, Masha V. Poyurovsky, Li Ma, Kellen Olszewski and Boyi Gan. https://www.nature.com/articles/s41467-023-39401-9
Cellular redox homeostasis maintained by malic enzyme 2 is essential for MYC-driven T cell lymphomagenesis – Wei Li, Junjie Kou, Zhenxi Zhang, Haoyue Li, Li Li and Wenjing Du. https://www.pnas.org/doi/10.1073/pnas.2217869120
Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis – Austin C. Boese, JiHoon Kang, Jung Seok Hwang, Jaehyun Kim, Kiyoung Eun, Courteney M. Malin, Kelly R. Magliocca, Chaoyun Pan, Lingtao Jin and Sumin Kang. https://www.pnas.org/doi/10.1073/pnas.2217332120
Amino acid starvation
Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis – Juan J Apiz Saab, Lindsey N Dzierozynski, Patrick B Jonker, Roya AminiTabrizi, Hardik Shah, Rosa Elena Menjivar, Andrew J Scott, Zeribe C Nwosu, Zhou Zhu, Riona N Chen, Moses Oh, Colin Sheehan, Daniel R Wahl, Marina Pasca di Magliano, Costas A Lyssiotis, Kay F Macleod, Christopher R Weber, Alexander Muir. https://elifesciences.org/articles/81289
Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response” – Julia A. Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R. Yates III, Taisuke Kanaji, Xiang-Lei Yang. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00643-5
Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity – Lan Fang, Yun Hao, Haihong Yu, Xuemei Gu, Qiao Peng, Huimin Zhuo, Yaxu Li, Zhiyuan Liu, Jia Wang, Yunfei Chen, Jiawen Zhang, Hongling Tian, Yaohui Gao, Renyuan Gao, Hongqi Teng, Zezhi Shan, Jiali Zhu, Zhiqiang Li, Yu’e Liu, Yiyi Zhang, Fei Yu, Zhang Lin, Yujun Hao, Xin Ge, Jian Yuan, Hong-Gang Hu, Yanlei Ma, Huan-Long Qin, Ping Wang. https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00173-3
Mitochondria
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma – Giulio Donati, Paola Nicoli, Alessandro Verrecchia, Veronica Vallelonga, Ottavio Croci, Simona Rodighiero, Matteo Audano, Laura Cassina, Aya Ghsein, Giorgio Binelli, Alessandra Boletta, Nico Mitro, Bruno Amati. https://www.embopress.org/doi/full/10.15252/emmm.202216910
A cytosolic surveillance mechanism activates the mitochondrial UPR – X – Reymond Sutandy, Ines Gößner, Georg Tascher and Christian Münch. https://www.nature.com/articles/s41586-023-06142-0
The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering non-imported proteins – Katharina Knöringer, Carina Groh, Lena Krämer, Kevin C. Stein, Katja G. Hansen, Jannik Zimmermann, Bruce Morgan, Johannes M. Herrmann, Judith Frydman, and Felix Boos. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E23-05-0205
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria – Déborah Naón, María Isabel Hernández-Alvarez, Satoko Shinjo, Milosz Wieczor, Saska Ivanova, Olga Martins de Brito, Albert Quintana, Juan Hidalgo, Manuel Palacín, Pilar Aparicio, Juan Castellanos, Luis Lores, David Sebastián, Sonia Fernández-Veledo, Joan Vendrell, Jorge Joven, Modesto Orozco, Antonio Zorzano, Luca Scorrano. https://www.science.org/doi/abs/10.1126/science.adh9351
A mitochondrial iron-responsive pathway regulated by DELE1 – Yusuke Sekine, Ryan Houston, Eva-Maria Eckl, Evelyn Fessler, Derek P. Narendra, Lucas T. Jae, Shiori Sekine. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00413-6
Structure of the human ATP synthase – Yuezheng Lai, Yuying Zhang, Shan Zhou, Jinxu Xu, Zhanqiang Du, Ziyan Feng, Long Yu, Ziqing Zhao, Weiwei Wang, Yanting Tang, Xiuna Yang, Luke W. Guddat, Fengjiang Liu, Yan Gao, Zihe Rao, Hongri Gong. https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00324-6
Mitochondrial uncoupling inhibits reductive carboxylation in cancer cells – Haowen Jiang, Clifford Jiajun He, Albert M. Li, Bo He, Yang Li, Meng-Ning Zhou, Jiangbin Ye. https://aacrjournals.org/mcr/article/doi/10.1158/1541-7786.MCR-23-0049/727512
AMPK
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1 – Tao Zhang, Daichao Xu, Elijah Trefts, Mingming Lv, Hiroyuki Inuzuka, Guobin Song, Min Liu, Jianlin Lu, Jianping Liu, Chen Chu, Min Wang, Huibing Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Dongxian Guan, Yuqin Men, Shuwen Jiang, Cong Jiang, Xiaoming Dai, Jing Liu, Zhen Wang, Peiqiang Yan, Jingchao Wang, Zhenbo Tu, Mrigya Babuta, Emily Erickson, Alissandra L. Hillis, Christian C. Dibble, John M. Asara, Gyongy Szabo, Piotr Sicinski, Ji Miao, Yu-Ru Lee, Lifeng Pan, Reuben J. Shaw, Junying Yuan, Wenyi Wei. https://www.science.org/doi/10.1126/science.abn1725
Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response – Ivan Tan, Shengli Xu, Jianxin Huo, Yuhan Huang, Hong-Hwa Lim, Kong-Peng Lam. https://www.jbc.org/article/S0021-9258(23)01934-8/fulltext
Metabolic regulation of misfolded protein import into mitochondria – Yuhao Wang, Linhao Ruan, Jin Zhu, Xi Zhang, Alexander Chih-Chieh Chang, Alexis Tomaszewski, Rong Li. https://elifesciences.org/reviewed-preprints/87518
Hypoxia
Glutamate dehydrogenase1 supports HIF‐1α stability to promote colorectal tumorigenesis under hypoxia – Kunhua Hu, Yufeng Ding, Hongwen Zhu, Xiaoqian Jing, Weiling He, Hua Yu, Xiongjun Wang. https://www.embopress.org/doi/abs/10.15252/embj.2022112675
Hypoxia induced responses are reflected in the stromal proteome of breast cancer – Silje Kjølle, Kenneth Finne, Even Birkeland, Vandana Ardawatia, Ingeborg Winge, Sura Aziz, Gøril Knutsvik, Elisabeth Wik, Joao A. Paulo, Heidrun Vethe, Dimitrios Kleftogiannis and Lars A. Akslen. https://www.nature.com/articles/s41467-023-39287-7
Cancer Immunometabolism
Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation – Sana Hibino, Shotaro Eto, Sho Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, Tsuyoshi Osawa, Tomoyoshi Soga, Tadatsugu Taniguchi and Hideyuki Yanai. https://www.pnas.org/doi/10.1073/pnas.2305245120
Reprogramming tumour-associated macrophages to outcompete cancer cells – Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan and Ming O. Li. https://www.nature.com/articles/s41586-023-06256-5
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment – Jie Cheng, Jinxin Yan, Ying Liu, Jiangzhou Shi, Haoyu Wang, Hanyang Zhou, Yinglin Zhou, Tongcun Zhang, Lina Zhao, Xianbin Meng, Haipeng Gong, Xinxiang Zhang, Haichuan Zhu, Peng Jiang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00171-7
Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignancies – Ernesto Lopez, Rajesh Karattil, Francesco Nannin, Gordon Weng-Kit Cheung, Lilian Denzler, Felipe Galvez-Cancino, Sergio Quezada and Martin A Pule. https://jitc.bmj.com/content/11/6/e006287
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma – Yu Qian, Ana Galan-Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Alissa Poteete, Fahao Zhang, Qi Wang, Jing Wang, Edwin Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I. Wistuba, Svena Verma, Taha Merghoub, Jedd D. Wolchok, Kwok-Kin Wong, Ralph J. DeBerardinis, John D. Minna, Natalie I. Vokes, Catherine B. Meador, Justin F. Gainor, Linghua Wang, Alexandre Reuben, John V. Heymach. https://www.sciencedirect.com/science/article/abs/pii/S1535610823001824
Arginase 1 is a key driver of immune suppression in pancreatic cancer – Rosa E Menjivar, Zeribe C Nwosu, Wenting Du, Katelyn L Donahue, Hanna S Hong, Carlos Espinoza, Kristee Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison Bischoff, Padma Kadiyala, Daniel Salas-Escabillas, Howard C Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J Halbrook, Costas A Lyssiotis, Marina Pasca di Magliano. https://elifesciences.org/articles/80721
Lipid metabolism
CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis – Jenna K. Minami, Danielle Morrow, Nicholas A. Bayley, Elizabeth G. Fernandez, Jennifer J. Salinas, Christopher Tse, Henan Zhu, Baolong Su, Rhea Plawat, Anthony Jones, Alessandro Sammarco, Linda M. Liau, Thomas G. Graeber, Kevin J. Williams, Timothy F. Cloughesy, Scott J. Dixon, Steven J. Bensinger, David A. Nathanson. https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00168-X
Miscellaneous
Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2 – Johanna Michl, Stefania Monterisi, Bobby White, Wiktoria Blaszczak, Alzbeta Hulikova, Gulnar Abdullayeva, Esther Bridges, Zinan Yin, Walter F. Bodmer, Pawel Swietach. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00612-5
Reviews
The metabolic cross-talk between cancer and T cells – Silvia Cadenas-De Miguel, Giulia Lucianer, Ilaria Elia. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(23)00080-4
Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages – Goutham Venkata Naga Davuluri, Chia-Hsin Chan. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16465
Comments
Staving off cell death – Grahame Hardie. https://www.science.org/doi/abs/10.1126/science.adi6827
A paradigm shift: AMPK negatively regulates ULK1 activity – Ji-Man Park and Do-Hyung Kim. https://www.tandfonline.com/doi/abs/10.1080/15548627.2023.2223465
Fumarate disarms CD8+ T cells against cancer – Luigi Nezi, Teresa Manzo. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00182-1
Autophagy fuels mitochondrial function through regulation of iron metabolism in pancreatic cancer – Subhadip Mukhopadhyay, Joel Encarnacion-Rosado and Alec C. Kimmelman. https://www.tandfonline.com/doi/abs/10.1080/15548627.2023.2223473
An Unexpected Partnership: Histone Deacetylase 6 and Glutaminase Inhibition Provide an Opportunity to Overcome Resistance in KRAS and LKB1 Co-mutant Lung Tumors – Brandon Nadres, Milica Momcilovic, David B. Shackelford, Aaron Lisberg. https://linkinghub.elsevier.com/retrieve/pii/S1556-0864(23)00516-6
LXR Signaling-Mediated Cholesterol Metabolism Reprogramming Regulates Cancer Cell Metastasis – Pankaj K. Singh, Kamiya Mehla. https://aacrjournals.org/cancerres/article-abstract/83/11/1759/726443
The pyrimidinosome is cancer’s Achilles’ heel – Matthew Dodson and Donna D. Zhang. https://www.nature.com/articles/s41556-023-01159-z
Other
Gina DeNicola: In vivo veritas – Lucia Morgado-Palacin. https://rupress.org/jcb/article/222/6/e202305044/214131
ISCaM 10th Annual Meeting – Systemic metabolism and cancer
London UK, The Francis Crick Institute. 17-19 September 2023
Metabolism and Cancer articles 