Glucose metabolism
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma – Jee-Eun Choi, Carlos Sebastian, Christina M. Ferrer, Caroline A. Lewis, Moshe Sade-Feldman, Thomas LaSalle, Anna Gonye, Begona G. C. Lopez, Walid M. Abdelmoula, Michael S. Regan, Murat Cetinbas, Gloria Pascual, Gregory R. Wojtkiewicz, Giorgia G. Silveira, Ruben Boon, Kenneth N. Ross, Itay Tirosh, Srinivas V. Saladi, Leif W. Ellisen, Ruslan I. Sadreyev, Salvador Aznar Benitah, Nathalie Y. R. Agar, Nir Hacohen and Raul Mostoslavsky. https://www.nature.com/articles/s42255-021-00350-6
Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer – Yinan Xiao, Ling Jin, Chaolin Deng, Ye Guan, Eleftheria Kalogera, Upasana Ray, Prabhu Thirusangu, Julie Staub, Sayantani Sarkar Bhattacharya, Haotian Xu, Xiaoling Fang and Viji Shridhar. https://www.nature.com/articles/s41388-020-01621-4
C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism – Yu Zhang, Qian Yan, Lanqi Gong, Hang Xu, Beilei Liu, Xiaona Fang, Dandan Yu, Lei Li, Ting Wei, Ying Wang, Ching Ngar Wong, Zhaojie Lyu, Ying Tang, Pak Chung Sham and Xin-Yuan Guan. https://www.nature.com/articles/s41388-020-01593-5
The Source of Glycolytic Intermediates in Mammalian Tissues – Tara TeSlaa, Caroline R. Bartman, Connor S.R. Jankowski, Zhaoyue Zhang, Xincheng Xu, Xi Xing, Lin Wang, Wenyun Lu, Sheng Hui, Joshua D. Rabinowitz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30728-2
Cysteine / Glutathione
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals – Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning. https://elifesciences.org/articles/63326
Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis – Muyun Liu, Dan Wang, Yongde Luo, Lianghao Hu, Yawei Bi, Juntao Ji, Haojie Huang, Guoqiang Wang, Liang Zhu, Jianjia Ma, Eunice Kim, Catherine K. Luo, James L. Abbruzzese, Xiaokun Li, Vincent W. Yang, Zhaoshen Li and Weiqin Lu. https://www.nature.com/articles/s41419-021-03473-6
Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11 – Subhadip Mukhopadhyay, Douglas E. Biancur, Seth J. Parker, Keisuke Yamamoto, Robert S. Banh, Joao A. Paulo, Joseph D. Mancias, and Alec C. Kimmelman. https://www.pnas.org/content/118/6/e2021475118.abstract?etoc
Amino acid metabolism
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth – Abigail S. Krall, Peter J. Mullen, Felicia Surjono, Milica Momcilovic, Ernst W. Schmid, Christopher J. Halbrook, Apisadaporn Thambundit, Steven D. Mittelman, Costas A. Lyssiotis, David B. Shackelford, Simon R.V. Knott, Heather R. Christofk. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00057-7
Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma – Shuai Wu, Takeshi Fukumoto, Jianhuang Lin, Timothy Nacarelli, Yemin Wang, Dionzie Ong, Heng Liu, Nail Fatkhutdinov, Joseph A. Zundell, Sergey Karakashev, Wei Zhou, Lauren E. Schwartz, Hsin-Yao Tang, Ronny Drapkin, Qin Liu, David G. Huntsman, Andrew V. Kossenkov, David W. Speicher, Zachary T. Schug, Chi Van Dang and Rugang Zhang. https://www.nature.com/articles/s43018-020-00160-x
Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc− for Glutathione Synthesis in Lung Cancer – Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P. Zhou, Shu-Hai Lin and Jiong Deng. https://cancerres.aacrjournals.org/content/81/3/552
Lipid metabolism
Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer – Nicole Oatman , Nupur Dasgupta, Priyanka Arora, Kwangmin Choi, Mruniya V. Gawali, Nishtha Gupta, Sreeja Parameswaran, Joseph Salomone, Julie A. Reisz, Sean Lawler, Frank Furnari, Cameron Brennan, Jianqiang Wu, Larry Sallans, Gary Gudelsky, Pankaj Desai, Brian Gebelein, Matthew T. Weirauch, Angelo D’Alessandro, Kakajan Komurov, Biplab Dasgupta. https://advances.sciencemag.org/content/7/7/eabd7459
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer – Ramona Rudalska, Jule Harbig, Marteinn T. Snaebjornsson, Sabrina Klotz, Stefan Zwirner, Liudmyla Taranets, Florian Heinzmann, Thales Kronenberger, Michael Forster, Wei Cui, Luana D’Artista, Elias Einig, Martina Hinterleitner, Werner Schmitz, Agata Dylawerska, Tae-Won Kang, Antti Poso, Mathias T. Rosenfeldt, Nisar P. Malek, Michael Bitzer, Stefan Laufer, Bernd J. Pichler, Nikita Popov, Almut Schulze, Lars Zender and Daniel Dauch. https://www.nature.com/articles/s43018-020-00168-3
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis – Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh III, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00080-2
Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer – Ji-Yoon Lee, Miso Nam, Hye Young Son, Kwangbeom Hyun, Seo Young Jang, Jong Woo Kim, Min Wook Kim, Youngae Jung , Eunji Jang, Seon-Jin Yoon 8, Jungeun Kim, Jihye Kim, Jinho Seo, Jeong-Ki Min, Kyoung-Jin Oh, Baek-Soo Han, Won Kon Kim, Kwang-Hee Bae, Jaewhan Song, Jaehoon Kim, Yong-Min Huh, Geum-Sook Hwang, Eun-Woo Lee, Sang Chul Lee. https://www.pnas.org/content/117/51/32433.long
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth – Katelyn D. Miller, Katherine Pniewski, Caroline E. Perry, Sara B. Papp, Joshua D. Shaffer, Jesse N. Velasco-Silva, Jessica C. Casciano, Tomas M. Aramburu, Yellamelli V.V. Srikanth, Joel Cassel, Emmanuel Skordalakes, Andrew V. Kossenkov, Joseph M. Salvino and Zachary T. Schug. https://cancerres.aacrjournals.org/content/81/5/1252
The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis – Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H.K. Wong, Ben S. Wittner, Hongshan Guo, Taronish D. Dubash, Moshe Sade-Feldman, Benjamin Wesley, Elad Horwitz, Genevieve M. Boland, Dieuwke L. Marvin, Todd Bonesteel, Chenyue Lu, François Aguet, Risa Burr, Samuel S. Freeman, Laxmi Parida, Katherine Calhoun, Michelle K. Jewett, Linda T. Nieman, Nir Hacohen, Anders M. Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran and Daniel A. Haber. https://cancerdiscovery.aacrjournals.org/content/11/3/678
Mitochondria
Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells – Nont Kosaisawe, Breanne Sparta, Michael Pargett, Carolyn K. Teragawa, John G. Albeck. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00014-0
Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential – Sarah Courtois, Beatriz de Luxán-Delgado, Laure Penin-Peyta, Alba Royo-García, Beatriz Parejo-Alonso, Petra Jagust, Sonia Alcalá, Juan A. Rubiolo, Laura Sánchez 5, Bruno Sainz, Jr., Christopher Heeschen, and Patricia Sancho. https://www.mdpi.com/2072-6694/13/4/698#
BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver – Maya Z. Springer, Logan P. Poole, Lauren E. Drake, Althea Bock-Hughes, Michelle L Boland, Alexandra G. Smith, John Hart, Aparajita H. Chourasia, Ivan Liu, Grazyna Bozek and Kay F Macleod. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1877469
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities – Luciano Garofano, Simona Migliozzi, Young Taek Oh, Fulvio D’Angelo, Ryan D. Najac, Aram Ko, Brulinda Frangaj, Francesca Pia Caruso, Kai Yu, Jinzhou Yuan, Wenting Zhao, Anna Luisa Di Stefano, Franck Bielle, Tao Jiang, Peter Sims, Mario L. Suvà, Fuchou Tang, Xiao-Dong Su, Michele Ceccarelli, Marc Sanson, Anna Lasorella and Antonio Iavarone. https://www.nature.com/articles/s43018-020-00159-4
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters – Florian A. Schober, David Moore, Ilian Atanassov, Marco F. Moedas, Paula Clemente, Ákos Végvári, Najla El Fissi, Roberta Filograna, Anna-Lena Bucher, Yvonne Hinze, Matthew The, Erik Hedman, Ekaterina Chernogubova, Arjana Begzati, Rolf Wibom, Mohit Jain, Roland Nilsson, Lukas Käll, Anna Wedell, Christoph Freyer, Anna Wredenberg. https://advances.sciencemag.org/content/7/8/eabf0717
Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability – Chen-Hua Chuang, Madeleine Dorsch, Philip Dujardin, Sukrit Silas, Kristina Ueffing, Johanna M. Hölken, Dian Yang, Monte M. Winslow and Barbara M. Grüner. https://cancerres.aacrjournals.org/content/81/3/567
Starvation, AMPK
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells – Nicholas J. Rossiter, Kimberly S. Huggler, Charles H. Adelmann, Heather R. Keys, Ross W. Soens, David M. Sabatini, Jason R. Cantor.. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00061-9
Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation – Andrey V Kuznetsov, Sabzali Javadov, Raimund Margreiter, Michael Grimm, Judith Hagenbuchner, Michael J Ausserlechner. https://www.sciencedirect.com/science/article/abs/pii/S0005272821000268
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53 – Peng Jiang, Lejiao Ren, Li Zhi, Zhong Yu, Fengxiang Lv, Fengli Xu, Wei Peng, Xiaoyu Bai, Kunlun Cheng, Li Quan, Xiuqin Zhang, Xianhua Wang, Yan Zhang, Dan Yang, Xinli Hu, Rui-Ping Xiao. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30900-X
AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ – Yuejing Jiang, Ying Dong, Yifeng Luo, Shangwen Jiang, Fei-Long Meng, Minjia Tan, Jia Li, Yi Zang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00026-7
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner – Franziska Kopietz; Yazeed Alshuweishi; Silvia Bijland; Fatmah Alghamdi; Eva Degerman; Kei Sakamoto; Ian P. Salt, Olga Göransson. https://portlandpress.com/biochemj/article-abstract/478/3/633/227673/
mTOR
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling – Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van ‘t Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck. https://www.cell.com/cell/fulltext/S0092-8674(20)31694-9
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C – Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, Emma Y. Wu, Matthew Kukurugya, Claire F. Maher, Rushika M. Perera, M. Paulina Ordonez, Roberto Zoncu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30925-4
Hypoxia
Homology-directed repair protects the replicating genome from metabolic assaults – Kumar Somyajit, Julian Spies, Fabian Coscia, Ufuk Kirik, Maj-Britt Rask, Ji-Hoon Lee, Kai John Neelsen, Andreas Mund, Lars Juhl Jensen, Tanya T. Paull, Matthias Mann, Jiri Lukas. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00069-1
The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI) – Yukino Kobayashi, Ami Oguro, Yuta Hirata, Susumu Imaoka. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246531
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis – Fang Zheng, Jianing Chen and Erwei Song. https://www.nature.com/articles/s41467-021-21535-3
Cancer Immunometabolism
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid – McLane J. Watson, Paolo D. A. Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie L. Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, Dario A. A. Vignali, Timothy W. Hand, Amanda C. Poholek, Brett M. Morrison, Jeffrey D. Rothstein, Stacy G. Wendell and Greg M. Delgoffe. https://www.nature.com/articles/s41586-020-03045-2
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours – Roberta Zappasodi, Inna Serganova, Ivan J. Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M. Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok and Taha Merghoub. https://www.nature.com/articles/s41586-021-03326-4
Lipid signalling enforces functional specialization of Treg cells in tumours – Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel and Hongbo Chi. https://www.nature.com/articles/s41586-021-03235-6
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors – Jang Hyun Park, Hyun-Jin Kim, Chae Won Kim, Hyeon Cheol Kim, Yujin Jung, Hyun-Soo Lee, Yunah Lee, Young Seok Ju, Ji Eun Oh, Sung-Hong Park, Jeong Ho Lee, Sung Ki Lee and Heung Kyu Lee. https://www.nature.com/articles/s41590-020-00860-7
Miscellaneous
NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes – Anju Singh, Anneleen Daemen, Dorothee Nickles, Sang-Min Jeon, Oded Foreman, Kuladeep Sudini, Florian Gnad, Stephane Lajoie, Naina Gour, Wayne Mitzner, Samit Chatterjee, Eun-Ji Choi, Buvana Ravishankar, Amy Rappaport, Namrata Patil, Mark McCleland, Leisa Johnson, George Acquaah-Mensah, Edward Gabrielson, Shyam Biswal and Georgia Hatzivassiliou. https://clincancerres.aacrjournals.org/content/27/3/877
Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation – Jung-Chin Chang, Simei Go, Eduardo H. Gilglioni, Suzanne Duijst, Daan M. Panneman, Richard J. Rodenburg, Hang Lam Li, Hsu-Li Huang, Lonny R. Levin, Jochen Buck, Arthur J. Verhoeven, Ronald P.J. Oude Elferink. https://www.sciencedirect.com/science/article/pii/S0005272820302176
NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition – Alexandra M. Moore, Lei Zhou, Jing Cui, Luyi Li, Nanping Wu, Alice Yu, Soumya Poddar, Keke Liang, Evan R. Abt, Stephanie Kim, Razmik Ghukasyan, Nooneh Khachatourian, Kristina Pagano, Irmina Elliott, Amanda M. Dann, Rana Riahi, Thuc Le, David W. Dawson, Caius G. Radu, and Timothy R. Donahue. https://www.pnas.org/content/118/8/e2012469118.abstract?etoc
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism – Ling-Yan Cai, Shi-Jie Chen, Sen-Hao Xiao, Qin-Juan Sun, Chen-Hong Ding, Bai-Nan Zheng, Xin-Yan Zhu, Shu-Qing Liu, Feng Yang, Ya-Xi Yang, Bing Zhou, Cheng Luo, Xin Zhang and Wei-Fen Xie. https://cancerres.aacrjournals.org/content/81/4/860
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer – Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, François Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji-Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. Dannenberg, Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00056-5
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice – Padma Kadiyala, Stephen V. Carney, Jessica C. Gauss, Maria B. Garcia-Fabiani, Santiago Haase, Mahmoud S. Alghamri, Felipe J. Núñez, Yayuan Liu, Minzhi Yu, Ayman Taher, Fernando M. Nunez, Dan Li, Marta B. Edwards, Celina G. Kleer, Henry Appelman, Yilun Sun, Lili Zhao, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, and Maria G. Castro. https://www.jci.org/articles/view/139542
Reviews
The metabolism of cancer cells during metastasis – Gabriele Bergers and Sarah-Maria Fendt. https://www.nature.com/articles/s41568-020-00320-2
Flexibility and Adaptation of Cancer Cells in a Heterogenous Metabolic Microenvironment – Gabriele Grasmann, Ayusi Mondal and Katharina Leithner. https://www.mdpi.com/1422-0067/22/3/1476
Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology – Elisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo and Javier A. Menendez. https://www.frontiersin.org/articles/10.3389/fonc.2020.620641/full
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases – Yanghe Zhang, Qingfei Meng, Qianhui Sun, Zhi-Xiang Xu, Honglan Zhou, Yishu Wang. https://www.sciencedirect.com/science/article/pii/S2212877820302052
Mitophagy in tumorigenesis and metastasis – Logan P Poole, Kay F Macleod. https://link.springer.com/article/10.1007%2Fs00018-021-03774-1
Mitochondrial dynamics in cancer stem cells – Dane T. Sessions and David F. Kashatus. https://link.springer.com/article/10.1007/s00018-021-03773-2
Comments
New Insights into Oncogenic Transformation: Elevating Antioxidant and Nucleotide Levels Does the Trick – Rushendhiran Kesavan, Halie Rion, Gerta Hoxhaj. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00016-9
Lethal lipotoxicity for liver cancer therapy – Suchira Gallage, Jose Efren Barragan Avila and Mathias Heikenwalder. https://www.nature.com/articles/s43018-021-00175-y
Activating T cells with asparagine – Wei Wong. https://stke.sciencemag.org/content/14/668/eabc6178
Tumour-regulated anorexia preceding cachexia – Gang Wang, Haiying Zhang and David Lyden. https://www.nature.com/articles/s41556-021-00635-8
How does obesity promote breast cancer tumor growth? – Marc L. Reitman. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00067-X
Obesity Promotes Metabolic Rewiring That Starves Cytotoxic T Cells – https://cancerdiscovery.aacrjournals.org/content/11/2/222.1
A Lung Cancer Subtype Depends on the Hexosamine Biosynthesis Pathway – https://cancerdiscovery.aacrjournals.org/content/11/2/OF9
Cryo-EM Structures Reveal Mechanism of Anticancer MCT1 Inhibitors – https://cancerdiscovery.aacrjournals.org/content/11/3/529.2
James R. Mitchell (1971–2020) – Michael Ristow, Chih-Hao Lee, Katrien De Bock, Vadim N. Gladyshev, Gökhan S. Hotamisligil, Brendan D. Manning. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00065-6
Metabolism and Cancer articles 