MetaboList – July 2017

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Starvation
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Entosis Is Induced by Glucose Starvation
Jens C. Hamann, Alexandra Surcel, Ruoyao Chen, Carolyn Teragawa, John G. Albeck, Douglas N. Robinson, Michael Overholtzer
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30851-3

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène, Marion Rubis, Veronique Secq, Stéphane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew G. Vander Heiden and Sophie Vasseur
https://www.nature.com/articles/ncomms16031

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias and Alec C. Kimmelman
https://www.nature.com/articles/ncomms15965

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
Truc B. Nguyen, Sharon M. Louie, Joseph R. Daniele, Quan Tran, Andrew Dillin, Roberto Zoncu, Daniel K. Nomura, James A. Olzmann
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30459-8

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells
Jun-Kyu Byun, Yeon-Kyung Choi, Ji-Hyun Kim, Ji Yun Jeong, Hui-Jeon Jeon, Mi-Kyung Kim, Ilseon Hwang, Shin-Yup Lee, You Mie Lee, In-Kyu Lee, Keun-Gyu Park
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30897-5

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival
Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, Lianfeng Wu, Ben Zhou, Lucydalila Cedillo, Michael C. Kacergis, Sean P. Curran, Alexander A. Soukas
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30899-9

Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells
H Takahashi, J Inoue, K Sakaguchi, M Takagi, S Mizutani and J Inazawa
http://www.nature.com/onc/journal/v36/n30/abs/onc201759a.html

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation
Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M. van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S. Sinsimer, Elisabeth A. Gavis, Christian Behrends, Catherine Rabouille
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30856-2

Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons
Cristian Gerónimo-Olvera, Teresa Montiel, Ruth Rincon-Heredia, Susana Castro-Obregón and Lourdes Massieu
http://www.nature.com/cddis/journal/v8/n6/full/cddis2017299a.html

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy
Derong Cui, Dawei Sun, Xintao Wang, Liye Yi, Ewa Kulikowicz, Michael Reyes, Junchao Zhu, Zeng-Jin Yang, Wei Jiang and Raymond C Koehler
http://www.nature.com/cddis/journal/v8/n7/abs/cddis2017318a.html

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Nutrient sensing
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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
Chen-Song Zhang ,Simon A. Hawley,Yue Zong,Mengqi Li,Zhichao Wang,Alexander Gray,Teng Ma,Jiwen Cui,Jin-Wei Feng,Mingjiang Zhu,Yu-Qing Wu,Terytty Yang Li,Zhiyun Ye,Shu-Yong Lin,Huiyong Yin, Hai-Long Piao, D. Grahame Hardie & Sheng-Cai Lin
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23275.html

Activation of the Unfolded Protein Response by Lipid Bilayer Stress
Kristina Halbleib, Kristina Pesek, Roberto Covino, Harald F. Hofbauer, Dorith Wunnicke, Inga Hänelt, Gerhard Hummer, Robert Ernst
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30439-2

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response
[yeast]
Elisa Ferrari, Christopher Bruhn, Marta Peretti, Corinne Cassani, Walter Vincenzo Carotenuto, Mohamed Elgendy, Ghadeer Shubassi, Chiara Lucca, Rodrigo Bermejo, Mario Varasi, Saverio Minucci, Maria Pia Longhese, Marco Foiani
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30367-2

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals
[yeast]
Marie-Pierre Péli-Gulli, Serena Raucci, Zehan Hu, Jörn Dengjel, Claudio De Virgilio
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30889-6

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Amino acid metabolism
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Extracellular vesicles are independent metabolic units with asparaginase activity
Nunzio Iraci, Edoardo Gaude, Tommaso Leonardi, Ana S H Costa, Chiara Cossetti, Luca Peruzzotti-Jametti, Joshua D Bernstock, Harpreet K Saini, Maurizio Gelati, Angelo Luigi Vescovi, Carlos Bastos, Nuno Faria, Luigi G Occhipinti, Anton J Enright, Christian Frezza & Stefano Pluchino
https://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2422.html

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
Yuchao Gu, Claudio P. Albuquerque, Daniel Braas, Wei Zhang, Genaro R. Villa, Junfeng Bi, Shiro Ikegami, Kenta Masui, Beatrice Gini, Huijun Yang, Timothy C. Gahman, Andrew K. Shiau, Timothy F. Cloughesy, Heather R. Christofk, Huilin Zhou, Kun-Liang Guan, Paul S. Mischel
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30394-5

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling
X Tang, C-K Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George, D P McDonnell, D S Hsu, J T Chang and J-T Chi
http://www.nature.com/onc/journal/v36/n30/abs/onc2016394a.html

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E. Johansson, Sofie Mohlin and Sven Påhlman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16904&path%5B%5D=54085

Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism
J Dong, D Xiao, Z Zhao, P Ren, C Li, Y Hu, J Shi, H Su, L Wang, H Liu, B Li, P Gao and G Qing
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201759a.html

ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma
A D Marshall, M van Geldermalsen, N J Otte, T Lum, M Vellozzi, A Thoeng, A Pang, R Nagarajah, B Zhang, Q Wang, L Anderson, J E J Rasko and J Holst
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201770a.html

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Hexose metabolism
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MPI [mannose phosphate isomerase] depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect
Nataly Shtraizent, Charles DeRossi, Shikha Nayar, Ravi Sachidanandam, Liora S Katz, Adam Prince, Anna P Koh, Adam Vincek, Yoav Hadas, Yujin Hoshida, Donald K Scott, Efrat Eliyahu, Hudson H Freeze, Kirsten C Sadler
https://elifesciences.org/articles/22477

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Surendra K. Shukla, Vinee Purohit, Kamiya Mehla, Venugopal Gunda, Nina V. Chaika, Enza Vernucci, Ryan J. King, Jaime Abrego, Gennifer D. Goode, Aneesha Dasgupta, Alysha L. Illies, Teklab Gebregiworgis, Bingbing Dai, Jithesh J. Augustine, Divya Murthy, Kuldeep S. Attri, Oksana Mashadova, Paul M. Grandgenett, Robert Powers, Quan P. Ly, Audrey J. Lazenby, Jean L. Grem, Fang Yu, José M. Matés, John M. Asara, Jung-whan Kim, Jordan H. Hankins, Colin Weekes, Michael A. Hollingsworth, Natalie J. Sarkova, Aaron R. Sasson, Jason B. Fleming, Jennifer M. Oliveto, Costas A. Lyssiotis, Lewis C. Cantley, Lyudmyla Berim, Pankaj K. Singh
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30254-4

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake
Srirupa Roy, Andrew M. Leidal, Jordan Ye, Sabrina M. Ronen, Jayanta Debnath
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30360-X

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan and S Kang
http://www.nature.com/onc/journal/v36/n27/abs/onc20176a.html

Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α
W Wan, K Peng, M Li, L Qin, Z Tong, J Yan, B Shen and C Yu
http://www.nature.com/onc/journal/v36/n27/abs/onc201713a.html

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
E A Hanse, C Ruan, M Kachman, D Wang, X H Lowman and A Kelekar
http://www.nature.com/onc/journal/v36/n27/abs/onc201736a.html

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo and Panu M. Jaakkola
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0167-y

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma
Y Shang, J He, Y Wang, Q Feng, Y Zhang, J Guo, J Li, S Li, Y Wang, G Yan, F Ren, Y Shi, J Xu, N Zeps, Y Zhai, D He and Z Chang
http://www.nature.com/onc/journal/v36/n29/abs/onc201731a.html

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Lipids
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mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
Walaa Eid, Kristin Dauner, Kevin C. Courtney, AnneMarie Gagnon, Robin J. Parks, Alexander Sorisky, and Xiaohui Zha
http://www.pnas.org/content/114/30/7999.abstract.html?etoc

Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth
Elissaveta Petrova, Arne Scholz, Juliane Paul, Andrea Sturz, Katja Haike, Franziska Siegel, Dominik Mumberg and Ningshu Liu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=12650&path%5B%5D=40079

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Mitochondria / Krebs
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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge, Estelle Saland, Fabienne de Toni, Nesrine Aroua, Mohsen Hosseini, Robin Perry, Claudie Bosc, Mayumi Sugita, Lucille Stuani, Marine Fraisse, Sarah Scotland,Clément Larrue, Héléna Boutzen, Virginie Féliu, Marie-Laure Nicolau-Travers, Stéphanie Cassant-Sourdy, Nicolas Broin, Marion David, Nizar Serhan, Audrey Sarry,Suzanne Tavitian, Tony Kaoma, Laurent Vallar, Jason Iacovoni, Laetitia K. Linares, Camille Montersino, Rémy Castellano, Emmanuel Griessinger, Yves Collette, Olivier Duchamp, Yara Barreira, Pierre Hirsch, Tony Palama, Lara Gales, François Delhommeau, Barbara H. Garmy-Susini, Jean-Charles Portais, François Vergez, Mary Selak,Gwenn Danet-Desnoyers, Martin Carroll, Christian Récher and Jean-Emmanuel Sarry
http://cancerdiscovery.aacrjournals.org/content/7/7/716

Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism
Ee Phie Tan, Steven R. McGreal, Stefan Graw, Robert Tessman, Scott J. Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E. Zachara, Devin C. Koestler, Kenneth R. Peterson, John P. Thyfault, Russell H. Swerdlow, Partha Krishnamurthy, Luciano DiTacchio, Udayan Apte, and Chad Slawson
http://www.jbc.org/content/early/2017/07/24/jbc.M117.797944.abstract

Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria
Julianna Dias Zeidler, Lorena O. Fernandes-Siqueira, Ana S. Carvalho, Eduardo Cararo-Lopes, Matheus H.S. Dias, Luisa A. Ketzer, Antonio Galina, and Andrea T. Da Poian
http://www.jbc.org/content/early/2017/06/29/jbc.M117.786582.abstract

Sorafenib Targets the Mitochondrial Electron Transport Chain Complexes and ATP Synthase to Activate the PINK1-Parkin Pathway and Modulate Cellular Drug Response
Conggang Zhang, Zeyu Liu, Eric Bunker, Adrian Ramirez, Schuyler Lee, Yinghua Peng, Aik Choon Tan, S Gail Eckhardt, Douglas A Chapnick, and Xuedong Liu
http://www.jbc.org/content/early/2017/07/03/jbc.M117.783175.abstract

Targeted exome sequencing of Krebs cycle genes reveals candidate cancer predisposing mutations in pheochromocytomas and paragangliomas.
Laura Remacha, Iñaki Comino-Méndez, Susan Richter, Laura Contreras, María Currás-Freixes, Guillermo Pita, Rocío Letón, Antonio Galarreta, Rafael Torres-Pérez, Emiliano Honrado, Scherezade Jiménez, Lorena Maestre, Sebastian Moran, Manel Esteller, Jorgina Satrústegui, Graeme Eisenhofer, Mercedes Robledo and Alberto Cascón
http://clincancerres.aacrjournals.org/content/early/2017/07/18/1078-0432.CCR-16-2250

Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma
Trisha Dwight, Un Na, Edward Kim, Ying Zhu, Anne Louise Richardson, Bruce G. Robinson, Katherine M. Tucker, Anthony J. Gill, Diana E. Benn, Roderick J. Clifton-Bligh and Dennis R. Winge
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3486-z

MITOCHONDRIAL PYRUVATE CARRIER FUNCTION DETERMINES CELL STEMNESS AND METABOLIC REPROGRAMMING IN CANCER CELLS
Xiaoli Li, Gaoyang Han, Xiaoran Li, Quancheng Kan, Zhirui Fan, Yaqing Li, Yasai Ji, Jing Zhao, Mingzhi Zhang,Mantas Grigalavicius, Viktor Berge, Mariusz Adam Goscinski, Jahn M. Nesland, and Zhenhe Suo
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18199&path%5B%5D=58346

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Hypoxia, HIFs
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Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress
Meiyan Jin, Gregory G. Fuller, Ting Han, Yao Yao, Amelia F. Alessi, Mallory A. Freeberg, Nathan P. Roach, James J. Moresco, Alla Karnovsky, Misuzu Baba, John R. Yates III, Aaron D. Gitler, Ken Inoki, Daniel J. Klionsky, John K. Kim
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30930-0

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1histone methyltransferase
Abhishek A. Chakraborty , Eijiro Nakamura, Jun Qi, Amanda Creech, Jacob D. Jaffe, Joshiawa Paulk, Jesse S. Novak, Kshithija Nagulapalli, Samuel K. McBrayer, Glenn S. Cowley, Javier Pineda, Jiaxi Song, Yaoyu E. Wang, Steven A. Carr, David E. Root, Sabina Signoretti, James E. Bradner, William G. Kaelin, Jr
http://stm.sciencemag.org/content/9/398/eaal5272

Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis
Y Zhang, Y-J Ren, L-C Guo, C Ji, J Hu, H-H Zhang, Q-H Xu, W-D Zhu, Z-J Ming, Y-S Yuan, X Ren, J Song and J-M Yang
http://www.nature.com/onc/journal/v36/n29/abs/onc201751a.html

GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness
M-C Lin, J-J Lin, C-L Hsu, H-F Juan, P-J Lou and M-C Huang
http://www.nature.com/onc/journal/v36/n30/abs/onc20178a.html

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E. Johansson, Sofie Mohlin and Sven Påhlman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16904&path%5B%5D=54085

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Metformin
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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan,R obert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real & Fredrik Bäckhed
http://www.nature.com/nm/journal/v23/n7/full/nm.4345.html

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells
Camille Loubiere, Stephan Clavel, Jerome Gilleron, Rania Harisseh, Jeremy Fauconnier, Issam Ben-Sahra, Lisa Kaminski, Kathiane Laurent, Stephanie Herkenne, Sandra Lacas-Gervais, Damien Ambrosetti, Damien Alcor, Stephane Rocchi, Mireille Cormont, Jean-François Michiels, Bernard Mari, Nathalie M. Mazure, Luca Scorrano, Alain Lacampagne, Abdallah Gharib, Jean-François Tanti & Frederic Bost
https://www.nature.com/articles/s41598-017-05052-2

Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment
Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, and Yoji Andrew Minamishima
http://mcb.asm.org/content/37/16/e00248-17.abstract?etoc

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Miscellaneous
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Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation
Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30905-1

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
Jason M Tanner, Claire Bensard, Peng Wei, Nathan M Krah, John C Schell, Jamie D Gardiner, Joshua D. Schiffman, Stephen L Lessnick and Jared Rutter
http://mcr.aacrjournals.org/content/early/2017/07/18/1541-7786.MCR-17-0182

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination
Sharanya Sivanand, Seth Rhoades, Qinqin Jiang, Joyce V. Lee, Joseph Benci, Jingwen Zhang, Salina Yuan, Isabella Viney, Steven Zhao, Alessandro Carrer, Michael J. Bennett, Andy J. Minn, Aalim M. Weljie, Roger A. Greenberg, Kathryn E. Wellen
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30435-5

Brief Report: Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma
Leo Rasche, Edgardo Angtuaco, James E. McDonald, Amy Buros, Caleb Stein, Charlotte Pawlyn, Sharmilan Thanendrarajan, Carolina Schinke, Rohan Samant, Shmuel Yaccoby, Brian A. Walker, Joshua Epstein, Maurizio Zangari, Frits van Rhee, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Richard Houlston, Bart Barlogie, Faith E. Davies, Gareth J. Morgan, and Niels Weinhold
http://bloodjournal.org/content/130/1/30.abstract?etoc

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Reviews
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Metabolic Interactions in the Tumor Microenvironment
Costas A. Lyssiotis, Alec C. Kimmelman
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Gabriela Andrejeva, Jeffrey C. Rathmell
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30346-7

Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
Hsiuchen Chen, David C. Chan
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30340-6

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Rigel J. Kishton, Madhusudhanan Sukumar, Nicholas P. Restifo
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30358-3

Ancillary Activity: Beyond Core Metabolism in Immune Cells
Daniel J. Puleston, Matteo Villa, Erika L. Pearce
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30362-5

The Mitochondrial Complex(I)ty of Cancer
Felix Urra, Felipe Muñoz, Alenka Lovy, and Cesar Cardenas
http://journal.frontiersin.org/article/10.3389/fonc.2017.00118/full

Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)
Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, and Teresa W.-M. Fan
http://m.jbc.org/content/292/28/11601.abstract.html

Nutrition, inflammation and cancer
Laurence Zitvogel, Federico Pietrocola and Guido Kroemer
http://www.nature.com/ni/journal/v18/n8/full/ni.3754.html

Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy
Sergio Rey, Luana Schito, Bradly G. Wouters, Scott Eliasof, Robert S. Kerbel
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30088-2

Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome.
Settas N, Faucz FR, Stratakis CA.
https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(17)30392-1

Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis
Dario C Altieri
http://www.nature.com/bjc/journal/v117/n3/full/bjc2017201a.html

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari et al.
http://www.nature.com/ncb/journal/v19/n8/full/ncb3578.html

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Comments
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Metabolism: Energy sensing through a sugar diphosphate
Bruce E. Kemp & Jonathan S. Oakhill
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23099.html

MUC-king with HIF May Rewire Pyrimidine Biosynthesis and Curb Gemcitabine Resistance in Pancreatic Cancer
Chi V. Dang
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30257-X

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer
Ana P. Gomes, Tanya Schild, John Blenis
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30546-4

Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells
Aaron D. Schimmer
http://cancerdiscovery.aacrjournals.org/content/7/7/670

Exploiting tumour addiction with a serine and glycine-free diet
Ivano Amelio, Gerry Melino and Christian Frezza
http://www.nature.com/cdd/journal/v24/n8/full/cdd201783a.html

Lipid Droplets Guard Mitochondria during Autophagy
Till Klecker, Ralf J. Braun, Benedikt Westermann
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30506-3

A novel role for a glycolytic pathway kinase in regulating autophagy has implications in cancer therapy
Aileen R. Ariosa & Daniel J. Klionsky
http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1321723

The skinny on obesity and cancer
Jaclyn Sceneay and Sandra S. McAllister
http://www.nature.com/ncb/journal/v19/n8/full/ncb3583.html

MetaboList – June 2017

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Amino acid and polyamine metabolism
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mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Amaia Zabala-Letona,Amaia Arruabarrena-Aristorena,Natalia Martín-Martín,Sonia Fernandez-Ruiz,James D. Sutherland, Michelle Clasquin,Julen Tomas-Cortazar,Jose Jimenez,Ines Torres,Phong Quang,Pilar Ximenez-Embun, Ruzica Bago,Aitziber Ugalde-Olano, Ana Loizaga-Iriarte,Isabel Lacasa-Viscasillas,Miguel Unda,Verónica Torrano,Diana Cabrera, Sebastiaan M. van Liempd,Ylenia Cendon,Elena Castro,Stuart Murray,Ajinkya Revandkar,Andrea Alimonti,Yinan Zhang,Amelia Barnett,Gina Lein,David Pirman,Ana R. Cortazar,Leire Arreal,Ludmila Prudkin,Ianire Astobiza,Lorea Valcarcel-Jimenez,Patricia Zuñiga-García,Itziar Fernandez-Dominguez,Marco Piva,Alfredo Caro-Maldonado, Pilar Sánchez-Mosquera,Mireia Castillo-Martín,Violeta Serra,Naiara Beraza, Antonio Gentilella, George Thomas, Mikel Azkargorta,Felix Elortza,Rosa Farràs, David Olmos,Alejo Efeyan,Juan Anguita,Javier Muñoz,Juan M. Falcón-Pérez, Rosa Barrio ,Teresa Macarulla,Jose M. Mato,Maria L. Martinez-Chantar,Carlos Cordon-Cardo,Ana M. Aransay,Kevin Marks,José Baselga,Josep Tabernero,Paolo Nuciforo, Brendan D. Manning, Katya Marjon & Arkaitz Carracedo
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature22964.html

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F. Orth, Catherine Verfaillie, Thomas G.P. Grunewald & Sarah-Maria Fendt
https://www.nature.com/articles/ncomms15267

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis
Boxi Zhang, Adi Zheng, Per Hydbring, Gorbatchev Ambroise, Amanda Tomie Ouchida, Michel Goiny, Helin Vakifahmetoglu-Norberg, Erik Norberg
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30724-6

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Glucose metabolism
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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
Haizhen Wang, Brandon N. Nicolay, Joel M. Chick, Xueliang Gao, Yan Geng, Hong Ren, Hui Gao, Guizhi Yang, Juliet A. Williams, Jan M. Suski, Mark A. Keibler, Ewa Sicinska, Ulrike Gerdemann, W. Nicholas Haining, Thomas M. Roberts, Kornelia Polyak, Steven P. Gygi, Nicholas J. Dyson & Piotr Sicinski
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature22797.html

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
S Ros, J Flöter, I Kaymak, C Da Costa, A Houddane, S Dubuis, B Griffiths, R Mitter, S Walz, S Blake, A Behrens, K M Brindle, N Zamboni, M H Rider and A Schulze
http://www.nature.com/onc/journal/v36/n23/full/onc2016477a.html

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
Pranavi Koppula, Yilei Zhang, Jiejun Shi, Wei Li, and Boyi Gan
http://www.jbc.org/content/early/2017/06/19/jbc.M117.798405.abstract

Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis
Marie C. Matrka, Miki Watanabe, Ranjithmenon Muraleedharan, Paul F. Lambert, Andrew N. Lane, Lindsey E. Romick-Rosendale , Susanne I. Wells
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177952

Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells
F Pepe, S Pagotto, S Soliman, C Rossi, P Lanuti, C Braconi, R Mariani-Costantini, R Visone and A Veronese
http://www.nature.com/oncsis/journal/v6/n5/abs/oncsis201735a.html

18F-FLUORODEOXYGLUCOSE UPTAKE PREDICTS PKM2 EXPRESSION IN LUNG ADENOCARCINOMA
Ping Huang, Xiang Zhao, Weiyuan Xiao, Yuqi Dong, and Guangyu Hu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=17377&path%5B%5D=55597

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Lipid metabolism
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Metabolic shifts in residual breast cancer drive tumor recurrence
Kristina M. Havas, Vladislava Milchevskaya, Ksenija Radic, Ashna Alladin, Eleni Kafkia, Marta Garcia, Jens Stolte, Bernd Klaus, Nicole Rotmensz, Toby J. Gibson, Barbara Burwinkel, Andreas Schneeweiss, Giancarlo Pruneri, Kiran R. Patil, Rocio Sotillo, Martin Jechlinger
http://www.jci.org/articles/view/89914

Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma
S Luo, Y Li, R Ma, J Liu, P Xu, H Zhang, K Tang, J Ma, N Liu, Y Zhang, Y Sun, T Ji, X Liang, X Yin, Y Liu, W Tong, Y Niu, N Wang, X Wang and B Huang
http://www.nature.com/onc/journal/v36/n25/abs/onc2016520a.html

NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition
Yanfen Cui, Pan Xing, Yuanyuan Wang, Miao Liu, Li Qiu, Guoguang Ying, Binghui Li
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=15936&path%5B%5D=50944

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
Javad Alizadeh, Amir A. Zeki, Nima Mirzaei, Sandipan Tewary, Adel Rezaei Moghadam, Aleksandra Glogowska, Pandian Nagakannan, Eftekhar Eftekharpour, Emilia Wiechec, Joseph W. Gordon, Fred. Y. Xu, Jared T. Field, Ken Y. Yoneda, Nicholas J. Kenyon, Mohammad Hashemi, Grant M. Hatch, Sabine Hombach-Klonisch, Thomas Klonisch & Saeid Ghavami
https://www.nature.com/articles/srep44841

A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling
H Muranaka, A Hayashi, K Minami, S Kitajima, S Kohno, Y Nishimoto, N Nagatani, M Suzuki, L A N Kulathunga, N Sasaki, N Okada, T Matsuzaka, H Shimano, H Tada and C Takahashi
http://www.nature.com/oncsis/journal/v6/n6/abs/oncsis201751a.html

TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway
F Yin, G Sharen, F Yuan, Y Peng, R Chen, X Zhou, H Wei, B Li, W Jing and J Zhao
http://www.nature.com/oncsis/journal/v6/n6/abs/oncsis201749a.html

Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism
Ting Ni, Zihao He, Yuanyuan Dai, Jingyue Yao, Qinglong Guo and Libin Wei
http://www.nature.com/cddis/journal/v8/n6/abs/cddis2017261a.html

LIPID DEGRADATION PROMOTES PROSTATE CANCER CELL SURVIVAL
Harri M. Itkonen, Michael Brown, Alfonso Urbanucci, Gregory Tredwell, Chung Ho Lau, Stefan Barfeld, Claire Hart,Ingrid J. Guldvik, Mandeep Takhar, Hannelore V. Heemers, Nicholas Erho, Katarzyna Bloch, Elai Davicioni, Rita Derua, Etienne Waelkens, James L. Mohler, Noel Clarke, Johan V. Swinnen, Hector C. Keun, Ole P. Rekvig, and Ian G. Mills
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=16123

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Mitochondria
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The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Elena Ansó, Samuel E. Weinberg, Lauren P. Diebold, Benjamin J. Thompson, Sébastien Malinge, Paul T. Schumacker, Xin Liu, Yuannyu Zhang, Zhen Shao, Mya Steadman, Kelly M. Marsh, Jian Xu, John D. Crispino & Navdeep S. Chandel
http://www.nature.com/ncb/journal/v19/n6/full/ncb3529.html

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
Xin Liu, Yuannyu Zhang, Min Ni, Hui Cao, Robert A. J. Signer, Dan Li, Mushan Li, Zhimin Gu, Zeping Hu, Kathryn E. Dickerson, Samuel E. Weinberg, Navdeep S. Chandel, Ralph J. DeBerardinis, Feng Zhou, Zhen Shao & Jian Xu
http://www.nature.com/ncb/journal/v19/n6/full/ncb3527.html

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
Alejandra Mendoza, Victoria Fang, Cynthia Chen, Madhavika Serasinghe, Akanksha Verma, James Muller, V. Sai Chaluvadi, Michael L. Dustin, Timothy Hla, Olivier Elemento, Jerry E. Chipuk & Susan R. Schwab
https://www.nature.com/nature/journal/v546/n7656/full/nature22352.html

Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition.
Andrew P. Trotta, Jesse D. Gelles, Madhavika N. Serasinghe, Patrick Loi, Jack L. Arbiser, and Jerry E. Chipuk
http://www.jbc.org/content/early/2017/05/25/jbc.M117.786442.abstract

CLUH couples mitochondrial distribution to the energetic and metabolic status
Jamal Wakim, David Goudenege, Rodolphe Perrot, Naig Gueguen, Valerie Desquiret-Dumas, Juan Manuel Chao de la Barca, Ilaria Dalla Rosa, Florence Manero, Morgane Le Mao, Stephanie Chupin, Arnaud Chevrollier, Vincent Procaccio, Dominique Bonneau, David C. Logan, Pascal Reynier, Guy Lenaers, and Salim Khiati
http://jcs.biologists.org/content/130/11/1940?etoc

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells
Davide Genini, Lara Brambilla, Erik Laurini, Jessica Merulla, Gianluca Civenni, Shusil Pandit, Rocco D’Antuono, Laurent Perez, David E. Levy, Sabrina Pricl, Giuseppina M. Carbone, and Carlo V. Catapano
http://www.pnas.org/content/114/25/E4924.abstract.html?etoc

Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells
Nathan P. Ward, Angela M. Poff, Andrew P. Koutnik, Dominic P. D’Agostino
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180061

Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming
Shujuan Sun, Jia Liu, Meisong Zhao, Yingyan Han, Pingbo Chen, Qingqing Mo, Beibei Wang, Gang Chen, Yong Fang, Yuan Tian, Jianfeng Zhou, Ding Ma, Qinglei Gao and Peng Wu
http://www.nature.com/cddis/journal/v8/n6/abs/cddis2017273a.html

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Epigenetics / IDH
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O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
Ting Wang, Qiujing Yu, Jingjie Li, Bin Hu, Qin Zhao, Chunmin Ma, Wenhua Huang, Lingang Zhuo, Houqin Fang, Lujian Liao, Y. Eugene Chin & Yuhui Jiang
http://www.nature.com/ncb/journal/v19/n7/full/ncb3562.html

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy
Xinjian Li, Willie Yu, Xu Qian, Yan Xia, Yanhua Zheng, Jong-Ho Lee, Wei Li, Jianxin Lyu, Ganesh Rao, Xiaochun Zhang, Chao-Nan Qian, Steven G. Rozen, Tao Jiang, Zhimin Lu
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30311-8

Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
Megan Reed Showalter, Jason Hatakeyama, Tomas Cajka, Kacey VanderVorst, Kermit L Carraway III, Oliver Fiehn and Reproducibility Project: Cancer Biology
https://elifesciences.org/articles/26030

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Hypoxia / angiogenesis
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Programmed mitophagy is essential for the glycolytic switch during cell differentiation
Lorena Esteban‐Martínez, Elena Sierra‐Filardi, Rebecca S McGreal, María Salazar‐Roa, Guillermo Mariño, Esther Seco, Sylvère Durand, David Enot, Osvaldo Graña, Marcos Malumbres, Ales Cvekl, Ana María Cuervo, Guido Kroemer, Patricia Boya
http://emboj.embopress.org/content/early/2017/04/27/embj.201695916.long

Imaging of hypoxia-inducible factor 1α and septin 9 interaction by bimolecular fluorescence complementation in live cancer cells
Maya Golan, Nicola J. Mabjeesh
http://impactjournals.us9.list-manage1.com/track/click?u=133779c099e52b6fa9d4dec2e&id=09057b1aa2&e=923b339f12

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression
Jing-Wen Shih, Wei-Fan Chiang, Alexander T. H. Wu, Ming-Heng Wu, Ling-Yu Wang, Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A. Changou, Yun Yen and Hsing-Jien Kung
https://www.nature.com/articles/ncomms15874

Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea
Antoni Vilaseca, Noelia Campillo, Marta Torres, Mireia Musquera, David Gozal, Josep M. Montserrat, Antonio Alcaraz, Karim A. Touijer, Ramon Farré, Isaac Almendros
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179444

A hypoxia-inducible factor 1α null splice variant lacking exon 10
Xiangyu Zhou, Weijia Zeng, Rui Peng and Hongyan Wang
http://www.nature.com/cddis/journal/v8/n6/full/cddis2017269a.html

STROMA-DERIVED HGF DRIVES METABOLIC ADAPTATION OF COLORECTAL CANCER TO ANGIOGENESIS INHIBITORS
Alessia Mira, Virginia Morello, Maria Virtudes Céspedes, Timothy Perera, Paolo M. Comoglio, Ramon Mangues, and Paolo Michieli
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=16942

The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth
Hyun Seung Ban, Bo-Kyung Kim, Hongsub Lee, Hwan Mook Kim, Dipesh Harmalkar, Miso Nam, Song-Kyu Park, Kiho Lee, Joon-Tae Park, Inhyub Kim, Kyeong Lee, Geum-Sook Hwang and Misun Won
http://www.nature.com/cddis/journal/v8/n6/abs/cddis2017235a.html

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Nutrient sensing / starvation
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Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
Natasha Emmanuel, Shoba Ragunathan, Qin Shan, Fang Wang, Andreas Giannakou, Nanni Huser, Guixian Jin, Jeremy Myers, Robert T. Abraham, Keziban Unsal-Kacmaz
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30685-X

Degradation of protein translation machinery by amino acid starvation-induced macroautophagy
Christine Gretzmeier, Sven Eiselein, Gregory R. Johnson, Rudolf Engelke, Heike Nowag, Mostafa Zarei, Victoria Küttner, Andrea C. Becker, Kristoffer T. G. Rigbolt, Maria Høyer-Hansen, Jens S. Andersen, Christian Münz, Robert F. Murphy & Jörn Dengjel
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1274485

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation
Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying Xiong, Shu-Yuan Guo, Hui-Yong Yin, Xu Lin, Qin Li, Catherine C. Y. Chang, Ta-Yuan Chang, Bo-Liang Li & Bao-Liang Song
http://www.nature.com/ncb/journal/v19/n7/full/ncb3551.html

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AMPK, mTOR, ATF4
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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
Chiara Di Malta , Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N. Eastes, Oliver Davis, Rossella De Cegli, Angela Zampelli, Luca G. Di Giovannantonio, Edoardo Nusco, Nick Platt, Alessandro Guida, Margret Helga Ogmundsdottir, Luisa Lanfrancone, Rushika M. Perera, Roberto Zoncu, Pier Giuseppe Pelicci, Carmine Settembre, Andrea Ballabio
http://science.sciencemag.org/content/356/6343/1188

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Sungki Hong, Mallory A Freeberg, Ting Han, Avani Kamath, Yao Yao, Tomoko Fukuda, Tsukasa Suzuki, John K Kim and Ken Inoki
https://elifesciences.org/articles/25237

Mitochondrial AKAP1 supports mTOR pathway and tumor growth
Laura Rinaldi, Maria Sepe, Rossella Delle Donne, Kristel Conte, Antonietta Arcella, Domenica Borzacchiello, Stefano Amente, Fernanda De Vita, Monia Porpora, Corrado Garbi, Maria A Oliva, Claudio Procaccini, Deriggio Faicchia, Giuseppe Matarese, Federica Zito Marino, Gaetano Rocco, Sara Pignatiello, Renato Franco, Luigi Insabato, Barbara Majello and Antonio Feliciello
http://www.nature.com/cddis/journal/v8/n6/abs/cddis2017241a.html

An In Vitro TORC1 Kinase Assay That Recapitulates the Gtr-Independent Glutamine-Responsive TORC1 Activation Mechanism on Yeast Vacuoles
Mirai Tanigawa and Tatsuya Maeda
http://mcb.asm.org/content/37/14/e00075-17.abstract?etoc

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Yiqun Zhang, Patrick Kwok-Shing Ng, Melanie Kucherlapati, Fengju Chen, Yuexin Liu, Yiu Huen Tsang, Guillermo de Velasco, Kang Jin Jeong, Rehan Akbani, Angela Hadjipanayis, Angeliki Pantazi, Christopher A. Bristow, Eunjung Lee, Harshad S. Mahadeshwar, Jiabin Tang, Jianhua Zhang, Lixing Yang, Sahil Seth, Semin Lee, Xiaojia Ren, Xingzhi Song, Huandong Sun, Jonathan Seidman, Lovelace J. Luquette, Ruibin Xi, Lynda Chin, Alexei Protopopov, Thomas F. Westbrook, Carl Simon Shelley, Toni K. Choueiri, Michael Ittmann, Carter Van Waes, John N. Weinstein, Han Liang, Elizabeth P. Henske, Andrew K. Godwin, Peter J. Park, Raju Kucherlapati, Kenneth L. Scott, Gordon B. Mills, David J. Kwiatkowski, Chad J. Creighton
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30168-X?

Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells
Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Kyung Min Chung, Caroline Jeeyeon Hong, Seong Who Kim, Eun-Kyoung Kim and Seong-Woon Yu
http://www.jbc.org/content/early/2017/06/27/jbc.M117.780874.abstract?papetoc

Deconvoluting AMP-dependent kinase (AMPK) adenine nucleotide binding and sensing
Xin Gu, Yan Yan, Scott J. Novick, Amanda Kovich, Devrishi Goswami, Jiyuan Ke, M. H. Eileen Tan, Lili Wang, Xiaodan Li, Parker de Waal, Martin R. Webb, Patrick R. Griffin, H. Eric Xu, and Karsten Melcher
http://www.jbc.org/content/early/2017/06/14/jbc.M117.793018.abstract

Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
Jennifer L. Bays, Hannah K. Campbell, Christy Heidema, Michael Sebbagh and Kris A. DeMali
http://www.nature.com/ncb/journal/v19/n6/full/ncb3537.html

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek & Tracy G. Anthony
https://www.nature.com/articles/s41598-017-01041-7

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
D Chen, Z Fan, M Rauh, M Buchfelder, I Y Eyupoglu and N Savaskan
http://www.nature.com.sire.ub.edu/onc/journal/vaop/ncurrent/full/onc2017146a.html

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Miscellaneous
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Mfn2 is critical for brown adipose tissue thermogenic function
Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera‐Alberni, Roy Combe, Antonio Zorzano, and Carles Cantó
http://EMBOJ.embopress.org/content/36/11/1543?etoc

Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins
Tatiana Tkatch, Elisa Greotti, Gytis Baranauskas, Diana Pendin, Soumitra Roy, Luliaoana I. Nita, Jennifer Wettmarshausen, Matthias Prigge, Ofer Yizhar, Orian S. Shirihai, Daniel Fishman, Michal Hershfinkel, Ilya A. Fleidervish, Fabiana Perocchi, Tullio Pozzan, and Israel Sekler
http://www.pnas.org/content/114/26/E5167.abstract.html?etoc

P53 SUPPRESSES RIBONUCLEOTIDE REDUCTASE VIA INHIBITING MTORC1
Zhengfu He, Xing Hu, Weijin Liu, Adrienne Dorrance, Ramiro Garzon, Peter J. Houghton, and Changxian Shen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=17440&path%5B%5D=59229

CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis
Hyunbae Kim, Ze Zheng, Paul D. Walker, Gregory Kapatos, and Kezhong Zhang
http://mcb.asm.org/content/37/14/e00048-17.abstract?etoc

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment
M Pérez-Alea, K McGrail, S Sánchez-Redondo, B Ferrer, G Fournet, J Cortés, E Muñoz, J Hernandez-Losa, S Tenbaum, G Martin, R Costello,I Ceylan, V Garcia-Patos and J A Recio
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2017160a.html

A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms
Bokai Zhu, Qiang Zhang, Yinghong Pan, Emily M. Mace, Brian York, Athanasios C. Antoulas, Clifford C. Dacso, Bert W. O’Malley
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30290-5

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism
Rongkun Tao,Yuzheng Zhao,Huanyu Chu,Aoxue Wang,Jiahuan Zhu,Xianjun Chen,Yejun Zou,Mei Shi,Renmei Liu,Ni Su,Jiulin Du,Hai-Meng Zhou,Linyong Zhu,Xuhong Qian,Haiyan Liu,Joseph Loscalzo& Yi Yang
http://www.nature.com/nmeth/journal/v14/n7/full/nmeth.4306.html

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Reviews
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Amino acid homeostasis and signalling in mammalian cells and organisms
Stefan Bröer and Angelika Bröer
http://www.biochemj.org/content/474/12/1935?etoc

Nutrient acquisition strategies of mammalian cells
Wilhelm Palm & Craig B. Thompson
http://www.nature.com/nature/journal/v546/n7657/full/nature22379.html

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
Daniel Garcia, Reuben J. Shaw
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30396-9

Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies
Guan-Zhong Qiu, Ming-Zhu Jin, Jin-Xiang Dai, Wei Sun, Ji-Hong Feng, Wei-Lin Jin
http://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147%2817%2930110-4

Fire and water: Tumor cell adaptation to metabolic conditions.
Cairns RA, Mak TW.
http://www.sciencedirect.com/science/article/pii/S0014482717302562

Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
C C Wong, Y Qian and J Yu
http://www.nature.com/onc/journal/v36/n24/full/onc2016485a.html

Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development
Lenny Dang and Shin-San Michael Su
http://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-061516-044732

Systems Biology of Metabolism
Jens Nielsen
http://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-061516-044757

Metabolite Measurement: Pitfalls to Avoid and Practices to Follow
Wenyun Lu, Xiaoyang Su, Matthias S. Klein, Ian A. Lewis, Oliver Fiehn, and Joshua D. Rabinowitz
http://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-061516-044952

The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression
Diana Pendin, Riccardo Filadi, and Paola Pizzo
http://journal.frontiersin.org/article/10.3389/fonc.2017.00102/full

Exploring Cancer Metabolism using Stable Isotope Resolved Metabolomics (SIRM)
Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, and Teresa W-M. Fan
http://www.jbc.org/content/early/2017/06/07/jbc.R117.776054.abstract

Biochimica et Biophysica Acta (BBA) – Bioenergetics special issue: Mitochondria in Cancer
Edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux
http://www.sciencedirect.com/science/article/pii/S0005272817300786

Including:
– Cancer metabolism in space and time: Beyond the Warburg effect
Pierre Danhier, Piotr Bański, Valéry L Payen, Debora Grasso, Luigi Ippolito, Pierre Sonveaux, Paolo E Porporato
– NO control of mitochondrial function in normal and transformed cells
Celia H. Tengan, Carlos T. Moraes
– Mitochondrial metabolism and energy sensing in tumor progression
Luisa Iommarini, Anna Ghelli, Giuseppe Gasparre, Anna Maria Porcelli
– Molecular and metabolic features of oncocytomas: Seeking the blueprints of indolent cancers
Monica De Luise, Giulia Girolimetti, Bernard Okere, Anna Maria Porcelli, Ivana Kurelac, Giuseppe Gasparre
– Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection
Satish Srinivasan, Manti Guha, Anna Kashina, Narayan G. Avadhani
– Calcium regulates cell death in cancer: Roles of the mitochondria and mitochondria-associated membranes (MAMs)
Alberto Danese, Simone Patergnani, Massimo Bonora, Mariusz R. Wieckowski, Maurizio Previati, Carlotta Giorgi, Paolo Pinton
– Manganese superoxide dismutase and glutathione peroxidase-1 contribute to the rise and fall of mitochondrial reactive oxygen species which drive oncogenesis
Dede N. Ekoue, Chenxia He, Alan M. Diamond, Marcelo G. Bonini
– Dysregulation of mitophagy in carcinogenesis and tumor progression
Joon Young Chang, Hyon-Seung Yi, Hyeon-Woo Kim, Minho Shong
– Expression and putative role of mitochondrial transport proteins in cancer
Oleksandr Lytovchenko, Edmund R.S. Kunji
– Mitochondrial uncoupling in cancer cells: Liabilities and opportunities
Gyorgy Baffy
– VDAC in cancer
Nathalie Mazure
– Drug discovery strategies in the field of tumor energy metabolism: Limitations by metabolic flexibility and metabolic resistance to chemotherapy
N.D. Amoedo, E. Obre, R. Rossignol
– Mitochondria and cancer chemoresistance
Flora Guerra, Arnaldo A. Arbini, Loredana Moro
– Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. A critical review of approaches and imaging biomarkers for therapeutic guidance
Bernard Gallez, Marie-Aline Neveu, Pierre Danhier, Bénédicte F. Jordan
– Energy metabolism in skin cancers: A therapeutic perspective
Mohsen Hosseini, Zeinab Kasraian, Hamid Reza Rezvani
– Metabolic synthetic lethality in cancer therapy
Vincent Zecchini, Christian Frezza

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Comments
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Cell cycle: Division enzyme regulates metabolism
Abigail S. Krall & Heather R. Christofk
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature22504.html

Cell forces meet cell metabolism
Tadamoto Isogai, Jin Suk Park & Gaudenz Danuser
http://www.nature.com/ncb/journal/v19/n6/full/ncb3542.html

NIX‐ing mitochondria: from development to pathology
Aleksandra Deczkowska, Michal Schwartz
http://emboj.embopress.org/content/early/2017/05/22/embj.201797110

Mitochondria link metabolism and epigenetics in hematopoiesis
John C. Schell and Jared Rutter
http://www.nature.com/ncb/journal/v19/n6/full/ncb3540.html

mTORC1 Controls Synthesis of Its Activator GTP
Don Benjamin, Michael N. Hall
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30685-X

The tuberous sclerosis complex gets fatter
Prashanth Gokare and Wafik S. El-Deiry
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=579f7e4ea9&e=923b339f12

METFORMIN INDUCES PROTEIN ACETYLATION IN CANCER CELLS
Ales Vancura, and Ivana Vancurova
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=017f55bfbf&e=923b339f12

Gene expression: ACSS2 boosts local histone acetylation
http://www.nature.com/nrm/journal/v18/n7/full/nrm.2017.61.html

LACTB-mediated tumour suppression by increased mitochondrial lipid metabolism
Danilo Cucchi and Claudio Mauro
http://www.nature.com/cdd/journal/v24/n7/full/cdd201760a.html

For Certain, SIRT4 Activities!
Surinder Kumar, David B. Lombard
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30105-6