MetaboList – October 2021


Diet and cancer


Low glycaemic diets alter lipid metabolism to influence tumour growth – Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin and Matthew G. Vander Heiden. https://www.nature.com/articles/s41586-021-04049-2

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition – Laura C. D. Pomatto-Watson, Monica Bodogai, Oye Bosompra, Jonathan Kato, Sarah Wong, Melissa Carpenter, Eleonora Duregon, Dolly Chowdhury, Priya Krishna, Sandy Ng, Emeline Ragonnaud, Roberto Salgado, Paula Gonzalez Ericsson, Alberto Diaz-Ruiz, Michel Bernier, Nathan L. Price, Arya Biragyn, Valter D. Longo and Rafael de Cabo. https://www.nature.com/articles/s41467-021-26431-4

Megakaryocytes Mediate Hyperglycemia-Induced Tumor Metastasis – Biying Wu, Ying Ye, Sisi Xie, Yintao Li, Xiaoting Sun, Mengyuan Lv, Ling Yang, Nan Cui, Qiying Chen, Lasse D. Jensen, Dongmei Cui, Guichun Huang, Ji Zuo, Shaochong Zhang, Wen Liu and Yunlong Yang. https://cancerres.aacrjournals.org/content/81/21/5506


Mitochondrial metabolism


Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis – Kazuki Heishima, Nobuhiko Sugito, Tomoyoshi Soga, Masashi Nishikawa, Yuko Ito, Ryo Honda, Yuki Kuranaga, Hiroki Sakai, Ryo Ito, Takayuki Nakagawa, Hiroshi Ueda, and Yukihiro Akao. https://www.jci.org/articles/view/139933

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia – Victoria da Silva-Diz, Bin Cao, Olga Lancho, Eric Chiles, Amer Alasadi, Maya Aleksandrova, Shirley Luo, Amartya Singh, Hanlin Tao, David Augeri, Sonia Minuzzo, Stefano Indraccolo, Hossein Khiabanian, Xiaoyang Su, Shengkan Jin, Daniel Herranz. https://ashpublications.org/blood/article-abstract/138/15/1317/475782/A-novel-and-highly-effective-mitochondrial

Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15 – Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore and John P. Kirwan. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00274-5

Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease – Shanshan Liu, Song Fu, Guodong Wang, Yu Cao, Lanlan Li, Xuemei Li, Jun Yang, Ning Li, Yabing Shan, Yang Cao, Yan Ma, Mengqiu Dong, Qinghua Liu, Hui Jiang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00283-7

Heme sequestration effectively suppresses the development and progression of both lung adenocarcinoma and squamous cell carcinoma – Sanchareeka Dey, Adnin Ashrafi, Chantal Vidal, Nivesh Jain, Sarada Preeta Kalainayakan, Poorva Ghosh, Parinaz Sadat Alemi, Narges Salamat, Purna Chaitanya Konduri, Jung-whan Kim and Li Zhang. https://mcr.aacrjournals.org/content/early/2021/10/11/1541-7786.MCR-21-0385.long

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer – Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb A. Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek and Funda Meric-Bernstam. https://cancerres.aacrjournals.org/content/81/21/5572


Nutrient sensing / starvation / AMPK


Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1 – Mengnan Zhu, Fukang Teng, Na Li, Li Zhang, Shuxian Zhang, Fan Xu, Jing Shao, Haipeng Sun, Huanhu Zhu. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00728-0

CCCP‐induced mitochondrial dysfunction – characterization and analysis of integrated stress response to cellular signaling and homeostasis – Ramagopal Reddy Koncha, Gayatri Ramachandran, Naresh Babu V. Sepuri, Kolluru V. A. Ramaiah. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15868

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly – Gea Cereghetti, Caroline Wilson-Zbinden, Vera M. Kissling, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, Paola Picotti, D. Allan Drummond, Uwe Sauer, Reinhard Dechant and Matthias Peter. https://www.nature.com/articles/s41556-021-00760-4

Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation – Jialiang Shao, Tiezhu Shi, Hua Yu, Yufeng Ding, Liping Li, Xiang Wang, Xiongjun Wang. https://www.embopress.org/doi/abs/10.15252/embj.2020107480

RIPK1 regulates starvation resistance by modulating aspartate catabolism – Xinyu Mei, Yuan Guo, Zhangdan Xie, Yedan Zhong, Xiaofen Wu, Daichao Xu, Ying Li, Nan Liu and Zheng-Jiang Zhu. https://www.nature.com/articles/s41467-021-26423-4

Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase – Ben Zhou, Yuyao Zhang, Sainan Li, Lianfeng Wu, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Alexander A. Soukas. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01244-4


Cancer Immunometabolism


Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity – Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart-Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, Xiaoyun Li, Zhengtao Xiao, Lydia N. Raines, Maryline Falquet, Antoine Jalil, Jason W. Locasale, Piergiorgio Percipalle, David Masson, Stanley Ching-Cheng Huang, Fabio Martinon, Julijana Ivanisevic and Ping-Chih Ho. https://www.nature.com/articles/s41590-021-01047-4

Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress – Lisa Holthaus, Virag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, Ezio Bonifacio. https://www.life-science-alliance.org/content/4/12/e202101013

Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP–Mediated Mitochondrial Dysfunction – Rong Jin, Jiaqing Hao, Yanmei Yi, Di Yin, Yuan Hua, Xiaohong Li, Hanmei Bao, Xianlin Han, Nejat K. Egilmez, Edward R. Sauter and Bing Li. https://cancerres.aacrjournals.org/content/81/20/5296

Macrophage-Derived Cholesterol Contributes to Therapeutic Resistance in Prostate Cancer – Asmaa El-Kenawi, William Dominguez-Viqueira, Min Liu, Shivanshu Awasthi, Julieta Abraham-Miranda, Aysenur Keske, KayLee K. Steiner, Leenil Noel, Amparo N. Serna, Jasreman Dhillon, Robert J. Gillies, Xiaoqing Yu, John M. Koomen, Kosj Yamoah, Robert A. Gatenby and Brian Ruffell. https://cancerres.aacrjournals.org/content/81/21/5477

Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies – Sabrina Cappello, Hsu-Min Sung, Christian Ickes, Christine S. Gibhardt, Adina Vultur, Hilal Bhat, Zhongwen Hu, Patricia Brafford, Andreas Denger, Ioana Stejerean-Todoran, Rixa-Mareike Köhn, Verena Lorenz, Nicolas Künzel, Gabriela Salinas, Hedwig Stanisz, Tobias Legler, Peter Rehling, Michael P. Schön, Karl S. Lang, Volkhard Helms, Meenhard Herlyn, Markus Hoth, Carsten Kummerow and Ivan Bogeski. https://cancerres.aacrjournals.org/content/81/21/5540

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming – Samantha M. Morrissey, Fan Zhang, Chuanlin Ding, Diego Elias Montoya-Durango, Xiaoling Hu, Chenghui Yang, Zhen Wang, Fang Yuan, Matthew Fox, Huang-ge Zhang, Haixun Guo, David Tieri, Maiying Kong, Corey T. Watson, Robert A. Mitchell, Xiang Zhang, Kelly M. McMasters, Jian Huang, Jun Yan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00421-6


Glucose metabolism


Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive hematopoietic progenitor growth – Cheuk Him Man, Francois Emile Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles Lin, Anskar YH Leung, David T Scadden. https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2021011563/477177

m6A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability – Hongjiang Liu, Shan Qin, Changqi Liu, Le Jiang, Chen Li, Jiankai Yang, Shunyao Zhang, Zhongjie Yan, Xiaopeng Liu, Jipeng Yang and Xiaofeng Sun. https://www.nature.com/articles/s41420-021-00674-y

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation – Irini Skaripa-Koukelli, David Hauton, John Walsby-Tickle, Eloïse Thomas, Joshua Owen, Abirami Lakshminarayanan, Sarah Able, James McCullagh, Robert C. Carlisle and Katherine A. Vallis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00273-6

TXNIP links anticipatory unfolded protein response to estrogen reprogramming glucose metabolism in breast cancer cells – Yuanzhong Wang, Shiuan Chen. https://doi.org/10.1210/endocr/bqab212


Cystine / Glutathione


SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells – Ying Wang, Frederick S. Yen, Xiphias Ge Zhu, Rebecca C. Timson, Ross Weber, Changrui Xing, Yuyang Liu, Benjamin Allwein, Hanzhi Luo, Hsi-Wen Yeh, Søren Heissel, Gokhan Unlu, Eric R. Gamazon, Michael G. Kharas, Richard Hite and Kıvanç Birsoy. https://www.nature.com/articles/s41586-021-04025-w

Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer – Ke-Ren Zhang, Yu-Fei Zhang, Hui-Min Lei, Ya-Bin Tang, Chun-Shuang Ma, Qian-Ming Lv, Shi-Yi Wang, Li-Ming Lu, Ying Shen, Hong-Zhuan Chen, Liang Zhu. https://www.science.org/doi/abs/10.1126/scitranslmed.abg6428

Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11 – Xinbo Wang, Yueqing Chen, Xudong Wang, Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yu’e Liu, Zhenyu Cai, Xinyuan Tong, Yi Luan, Xiao Tan, Bing Luan, Xin Ge, Hongbin Ji, Xuejun Jiang and Ping Wang. https://cancerres.aacrjournals.org/content/81/20/5217

RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11 – Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He, Luning Wang, Dan Chen, Shujun Fan, Huan Chen, Hai-Long Piao, Qinglong Qiao, Zhaochao Xu, Jinrui Zhang, Jinyao Zhao, Sirui Zhang, Yue Yin, Chao Peng, Xiaoling Li, Quentin Liu, Han Liu, Yang Wang. https://www.jci.org/articles/view/15206


Amino acid metabolism


The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells – Marc Hennequart, Christiaan F. Labuschagne, Mylène Tajan, Steven E. Pilley, Eric C. Cheung, Nathalie M. Legrave, Paul C. Driscoll and Karen H. Vousden. https://www.nature.com/articles/s41467-021-26395-5

The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress – Chunmin Ma, Ke Zheng, Kun Jiang, Qin Zhao, Nannan Sha, Wang Wang, Man Yan, Tao Chen, Yuzheng Zhao and Yuhui Jiang. https://www.nature.com/articles/s42255-021-00456-x

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1 – Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol-Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12999


Lipid metabolism


p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth – Huishan Sun, Li Li, Wei Li, Fan Yang, Zhenxi Zhang, Zizhao Liu, Wenjing Du. https://www.embopress.org/doi/abs/10.15252/embr.202152537

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer – Ser Yue Loo, Li Ping Toh, William Haowei Xie, Elina Pathak, Wilson Tan, Siming Ma, May Yin Lee, S. Shatishwaran, Joanna Zhen Zhen Yeo, Ju Yuan, Yin Ying Ho, Esther Kai Lay Peh, Magendran Muniandy, Federico Torta, Jack Chan, Tira J. Tan, Yirong Sim, Veronique Tan, Benita Tan, Preetha Madhukumar, Wei Sean Yong, Kong Wee Ong, Chow Yin Wong, Puay Hoon Tan, Yoon Sim Yap, Lih-Wen Deng, Rebecca Dent, Roger Foo, Markus R. Wenk, Soo Chin Lee, Ying Swan Ho, Elaine Hsuen Lim, Wai Leong Tam. https://www.science.org/doi/full/10.1126/sciadv.abh2443

Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC – Sagar D. Sardesai, Alexandra Thomas, Christopher Gallagher, Filipa Lynce, Yvonne Lynn Ottaviano, Tarah Jean Ballinger, Bryan P. Schneider, Anna Maria Storniolo, Amber Bauchle, Sandra K. Althouse, Susan M. Perkins, Andrea R. Masters, Robert E. Stratford Jr, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang and Kathy D. Miller. https://clincancerres.aacrjournals.org/content/27/21/5810

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells – Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez and Ruth Lupu. https://www.nature.com/articles/s41419-021-04262-x

Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements – Vasiliki Symeonidou, Hélène Jakobczyk, Salem Bashanfer, Camille Malouf, Foteini Fotopoulou, Rishi S. Kotecha, Richard A. Anderson, Andrew J. Finch, Katrin Ottersbach. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01370-X

ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells – Jillian Hattaway Luttman Jacob P. Hoj, Kevin H. Lin,  Jiaxing Lin, Jing Jin Gu,  Clay Rouse, Amanda G. Nichols, Nancie J. MacIver, Kris C. Wood, Ann Marie Pendergast. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01350-4

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma – Francesca Puca, Fei Yu, Caterina Bartolacci, Piergiorgio Pettazzoni, Alessandro Carugo, Emmet Huang-Hobbs, Jintan Liu, Ciro Zanca, Federica Carbone, Edoardo Del Poggetto, Joy Gumin, Pushan Dasgupta, Sahil Seth, Sanjana Srinivasan, Frederick F. Lang, Erik P. Sulman, Philip L. Lorenzi, Lin Tan, Mengrou Shan, Zachary P. Tolstyka, Maureen Kachman, Li Zhang, Sisi Gao, Angela K. Deem, Giannicola Genovese, Pier Paolo Scaglioni, Costas A. Lyssiotis, Andrea Viale and Giulio F. Draetta. https://cancerdiscovery.aacrjournals.org/content/11/11/2904


Miscellaneous


Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels – Isabel Kurth, Norihiro Yamaguchi, Celia Andreu-Agullo, Helen S. Tian, Subhasree Sridhar, Shugaku Takeda, Foster C. Gonsalves, Jia Min Loo, Afsar Barlas, Katia Manova-Todorova, Robert Busby, Johanna C. Bendell, James Strauss, Marwan Fakih, Autumn J. McRee, Andrew E. Hendifar, Lee S. Rosen, Andrea Cercek, Robert Wasserman, Michael Szarek, Scott L. Spector, Syed Raza, Masoud F. Tavazoie, Sohail F. Tavazoie. https://www.science.org/doi/full/10.1126/sciadv.abi7511

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy – Gang Wei, Honglin Sun, Kai Dong, Libing Hu, Qi Wang, Qian Zhuang, Yan Zhu, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang, Junli Liu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00375-2

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas – Nieves Calvo-Vidal, Nahuel Zamponi, Jan Krumsiek, Max A. Stockslager, Maria V. Revuelta, Jude M. Phillip, Rossella Marullo, Ekaterina Tikhonova, Nikita Kotlov, Jayeshkumar Patel, Shao Ning Yang, Lucy Yang, Tony Taldone, Catherine Thieblemont, John P. Leonard, Peter Martin, Giorgio Inghirami, Gabriela Chiosis, Scott R. Manalis and Leandro Cerchietti. https://cancerres.aacrjournals.org/content/81/20/5202


Reviews


Physiological impact of in vivo stable isotope tracing on cancer metabolism – Manuel Grima-Reyes, Adriana Martinez-Turtos, Ifat Abramovich, Eyal Gottlieb, Johanna Chiche, Jean-Ehrland Ricci. https://www.sciencedirect.com/science/article/pii/S2212877821001393

New roles for gluconeogenesis in vertebrates – Katharina Leithner. https://www.sciencedirect.com/science/article/pii/S2452310021000846

A map of the altered glioma metabolism – Ruhi Deshmukh, Maria Francesca Allega, Saverio Tardito. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00196-9

Redox Regulation in Cancer Cells during Metastasis – Alpaslan Tasdogan, Jessalyn M. Ubellacker, and Sean J. Morrison. https://cancerdiscovery.aacrjournals.org/content/11/11/2682

The role of lysosomal membrane proteins in glucose and lipid metabolism – Jing Gu, Mengya Geng, Mengxiang Qi, Lizhuo Wang, Yao Zhang, Jialin Gao. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202002602R

The Intersection of Purine and Mitochondrial Metabolism in Cancer – Humberto De Vitto, Danushka B. Arachchige, Brian C. Richardson and Jarrod B. French. https://www.mdpi.com/2073-4409/10/10/2603

Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward – Maria Rain Jennings, David Munn, John Blazeck. https://jitc.bmj.com/content/9/10/e003013

Pharmacological targeting of endoplasmic reticulum stress in disease – Stefan J. Marciniak, Joseph E. Chambers and David Ron. https://www.nature.com/articles/s41573-021-00320-3

Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors – Sayani Patra, Naveed Elahi, Aaron Armorer, Swathi Arunachalam, Joshua Omala, Iman Hamid, Anthony W Ashton, David Joyce, Xuanmao Jiao, Richard G Pestell.. https://www.frontiersin.org/articles/10.3389/fonc.2021.700629/full

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis – Shuo Yu, Simin Meng, Meixiang Xiang, Hong Ma. https://www.sciencedirect.com/science/article/pii/S2212877821001022


Comments


Nuclear PHGDH protects cancer cells from nutrient stress – Daniela Annibali and Sarah-Maria Fendt. https://www.nature.com/articles/s42255-021-00448-x

A leucine-derived fatty acid unlocks the mTOR to development – Chung-Yang Yeh, Dudley W. Lamming. https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00735-8

Diet comparison suggests a lipid imbalance can slow tumour growth – Giulia Salvadori and Valter D. Longo. https://www.nature.com/articles/d41586-021-02775-1

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