MetaboList – December 2021


Glycolysis and the PPP


Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis – Yangmiao Duan, Jingyi Li, Fengqin Wang, Junmin Wei, Zhongfa Yang, Mingxin Sun, Jia Liu, Mingxin Wen, Wan Huang, Zhinan Chen, Zhimin Lu, Jing-Hua Yang, Guangwei Wei. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01633-8

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis – Mi Kyung Park, Li Zhang, Kyung-Won Min, Jung-Hyun Cho, Chih-Chen Yeh, Hyesu Moon, Daniel Hormaechea-Agulla, Hyejin Mun, Seungbeom Ko, Ji Won Lee, Sonali Jathar, Aubrey S. Smith, Yixin Yao, Nguyen Thu Giang, Hong Ha Vu, Victoria C. Yan, Mary C. Bridges, Antonis Kourtidis, Florian Muller, Jeong Ho Chang, Su Jung Song, Shinichi Nakagawa, Tetsuro Hirose, Je-Hyun Yoon, Min Sup Song. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00539-8

Structure and mechanism of the SGLT family of glucose transporters – Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J. Robertson, Yan Xu, Ron O. Dror, Georgios Skiniotis and Liang Feng. https://www.nature.com/articles/s41586-021-04211-w

Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin – Daniela Šimčíková, Dominik Gardáš, Kateřina Hložková, Martin Hruda, Petr Žáček, Lukáš Rob and Petr Heneberg. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00277-2

Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis – Shuyu Yu, Weicheng Zang, Yuchong Qiu, Liming Liao and Xiaofeng Zheng. https://www.nature.com/articles/s41388-021-02071-2

NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma – Zhuolin Li, Yuxin He, Yanjun Li, Juan Li, Hezhao Zhao, Guanbing Song, Makoto Miyagishi, Shourong Wu and Vivi Kasim. https://www.nature.com/articles/s41388-021-02063-2


Hexosamines


Glutamine deprivation triggers NAGK-dependent hexosamine salvage – Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen. https://elifesciences.org/articles/62644

Hyaluronic acid fuels pancreatic cancer cell growth – Peter K Kim, Christopher J Halbrook, Samuel A Kerk, Megan Radyk, Stephanie Wisner, Daniel M Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D Welling, Li Zhang, Matthew R Pratt, Kayvan R Keshari, Haoqiang Ying, Costas A Lyssiotis. https://elifesciences.org/articles/62645


Amino acids/Urea


Valine tRNA levels and availability regulate complex I assembly in leukaemia – Palaniraja Thandapani, Andreas Kloetgen, Matthew T. Witkowski, Christina Glytsou, Anna K. Lee, Eric Wang, Jingjing Wang, Sarah E. LeBoeuf, Kleopatra Avrampou, Thales Papagiannakopoulos, Aristotelis Tsirigos and Iannis Aifantis. https://www.nature.com/articles/s41586-021-04244-1

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism – Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith and M. Celeste Simon. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00271-8

Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells – Peter F. Doubleday, Luca Fornelli, Ioanna Ntai, Neil L. Kelleher. https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16111


Lipid metabolism


The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes – Lacroix M, Linares LK, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, Fau C, Gayte L, Blanchet E, Mairal A, Derua R, Cardona F, Beuzelin D, Annicotte JS, Pirot N, Torro A, Tinahones FJ, Bernex F, Bertrand-Michel J, Langin D, Fajas L, Swinnen JV, Le Cam L. https://www.nature.com/articles/s41467-021-27307-3

Induction of SREBP1 degradation coupled with suppression of SREBP1-mediated lipogenesis impacts the response of EGFR mutant NSCLC cells to osimertinib – Zhen Chen, Danlei Yu, Taofeek K. Owonikoko, Suresh S. Ramalingam and Shi-Yong Sun. https://www.nature.com/articles/s41388-021-02057-0

NAD kinase sustains lipogenesis and mitochondrial metabolism through fatty acid synthesis – Mengyao Xu, Long Ding, Jingjing Liang, Xiao Yang, Yuan Liu, Yingchun Wang, Mei Ding, Xun Huang. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01653-3?


Mitochondria


AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia – Adrien Grenier, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, Clement Larrue, Ambrine Sahal, Rudy Birsen, Victoria Ghesquier, Justine Decroocq, Fetta Mazed, Mireille Lambert, Mamy Andrianteranagna, Benoit Viollet, Patrick Auberger, Andrew A. Lane, Pierre Sujobert, Didier Bouscary, Jean-Emmanuel Sarry, Jerome Tamburini. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01701-0

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis – Divya Ramchandani, Mirela Berisa, Diamile A. Tavarez, Zhuoning Li, Matthew Miele, Yang Bai, Sharrell B. Lee, Yi Ban, Noah Dephoure, Ronald C. Hendrickson, Suzanne M. Cloonan, Dingcheng Gao, Justin R. Cross, Linda T. Vahdat and Vivek Mittal. https://www.nature.com/articles/s41467-021-27559-z

Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect – Jianong Zhang, Liang Zhang, Ji Nie, Yan Lin, Yao Li, Wei Xu, Jian-Yuan Zhao, Shi-Min Zhao & Chenji Wang. https://www.nature.com/articles/s41388-021-02065-0

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen – Mara Mennuni, Roberta Filograna, Andrea Felser, Nina A Bonekamp, Patrick Giavalisco, Oleksandr Lytovchenko, Nils-Göran Larsson. https://www.embopress.org/doi/full/10.15252/embr.202153054


Starvation


Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes – Wen-Chuan Hsieh, Benjamin M. Sutter, Holly Ruess, Spencer D. Barnes, Venkat S. Malladi, Benjamin P. Tu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)01077-7

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis – Lianggong Ding, Wenfei Sun, Miroslav Balaz, Anyuan He, Manuel Klug, Stefan Wieland, Robert Caiazzo, Violeta Raverdy, Francois Pattou, Philippe Lefebvre, Irfan J. Lodhi, Bart Staels, Markus Heim and Christian Wolfrum. https://www.nature.com/articles/s42255-021-00489-2

Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis – Hyeon-Ok Jin, Sung-Eun Hong, Ji-Young Kim, Se-Kyeong Jang and In-Chul Park. https://www.nature.com/articles/s41419-021-04417-w


Cancer Immunometabolism


Coenzyme A fuels T cell anti-tumor immunity – Michael St. Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Céline Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, Pamela S. Ohashi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00538-6

Macrophages are metabolically heterogeneous within the tumor microenvironment – Xenia Geeraerts, Juan Fernández-Garcia, Felix J. Hartmann, Kyra E. de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C. Bendall, Damya Laoui, Jan Van den Bossche, Sarah-Maria Fendt, Jo A. Van Ginderachter. https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01671-5

A purine metabolic checkpoint that prevents autoimmunity and autoinflammation – Svetlana Saveljeva, Gavin W. Sewell, Katharina Ramshorn, M. Zaeem Cader, James A. West, Simon Clare, Lea-Maxie Haag, Rodrigo Pereira de Almeida Rodrigues, Lukas W. Unger, Ana Belén Iglesias-Romero, Lorraine M. Holland, Christophe Bourges, Muhammad N. Md-Ibrahim, James O. Jones, Richard S. Blumberg, James C. Lee, Nicole C. Kaneider, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Arthur Kaser. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00628-8


Miscellaneous


Metabolic drug survey highlights cancer cell dependencies and vulnerabilities – Tea Pemovska, Johannes W. Bigenzahn, Ismet Srndic, Alexander Lercher, Andreas Bergthaler, Adrián César-Razquin, Felix Kartnig, Christoph Kornauth, Peter Valent, Philipp B. Staber and Giulio Superti-Furga. https://www.nature.com/articles/s41467-021-27329-x

Screening human lung cancer with predictive models of serum magnetic resonance spectroscopy metabolomics – Tjada A. Schult, Mara J. Lauer, Yannick Berker, Marcella R. Cardoso, Lindsey A. Vandergrift, Piet Habbel, Johannes Nowak, Matthias Taupitz, Martin Aryee, Mari A. Mino-Kenudson, David C. Christiani, and Leo L. Cheng. https://www.pnas.org/content/118/51/e2110633118.abstract?etoc

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness – Pravat Kumar Parida, Mauricio Marquez-Palencia, Vidhya Nair, Akash K. Kaushik, Kangsan Kim, Jessica Sudderth, Eduardo Quesada-Diaz, Ambar Cajigas, Vamsidhara Vemireddy, Paula I. Gonzalez-Ericsson, Melinda E. Sanders, Bret C. Mobley, Kenneth Huffman, Sunati Sahoo, Prasanna Alluri, Cheryl Lewis, Yan Peng, Robert M. Bachoo, Carlos L. Arteaga, Ariella B. Hanker, Ralph J. DeBerardinis, Srinivas Malladi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00620-3


Reviews


Targeting cancer metabolism in the era of precision oncology – Zachary E. Stine, Zachary T. Schug, Joseph M. Salvino and Chi V. Dang. https://www.nature.com/articles/s41573-021-00339-6

The N-terminal cysteine is a dual sensor of oxygen and oxidative stress – Ah Jung Heo, Su Bin Kim, Chang Hoon Ji, Dohyun Han, Su Jin Lee, Su Hyun Lee, Min Ju Lee, Ji Su Lee, Aaron Ciechanover, Bo Yeon Kim, and Yong Tae Kwon – https://www.pnas.org/content/118/50/e2107993118.abstract?etoc

Revisiting the HIF switch in the tumor and its immune microenvironment – Sophie J. Cowman, Mei Yee Koh. https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00209-0

Molecular aspects of fructose metabolism and metabolic disease – Mark A. Herman, Morris J. Birnbaum. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00429-0

“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis – Mark A. Febbraio, Michael Karin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00423-X


Comments


Dinner is served, sir: Fighting cancer with the right diet – Andrés Méndez-Lucas, Mariia Yuneva. https://www.cell.com/cell/fulltext/S0092-8674(21)01386-6

CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way – Ameeta Kelekar, Stephen C. Jameson. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00537-4

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