MetaboList – June 2018

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Glucose metabolism
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Four Key Steps Control Glycolytic Flux in Mammalian Cells
Lukas Bahati Tanner, Alexander G. Goglia, Monica H. Wei, Talen Sehgal, Lance R. Parsons, Junyoung O. Park, Eileen White, Jared E. Toettcher, Joshua D. Rabinowitz
https://www.cell.com/cell-systems/fulltext/S2405-4712(18)30243-6

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis
Pengcheng Bu, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, Lihua Wang, Rui Xi, Inna Astapova, Yan Han, Jiahe Li, Bradley B. Barth, Min Lu, Ziyang Gao, Robert Mines, Liwen Zhang, Mark Herman, David Hsu, Guo-Fang Zhang, Xiling Shen
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30244-4

Mathematical Modeling of the Function of Warburg Effect in Tumor Microenvironment
Milad Shamsi, Mohsen Saghafian, Morteza Dejam & Amir Sanati-Nezhad
https://www.nature.com/articles/s41598-018-27303-6

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai and Harvey R. Herschman
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0181-8

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino and Letizia Lanzetti
http://cancerres.aacrjournals.org/content/78/13/3432

Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis
Qian Sun, Shuzhan Li, Yanan Wang, Haiyong Peng, Xiying Zhang, Yu Zheng, Chunjia Li, Li Li, Rongrong Chen, Xinxin Chen, Wenjing Bai, Xiangli Jiang, Liang Liu, Feng Wei, Boshi Wang, Yu Zhang, Hui Li, Xiubao Ren & Hongbing Zhang
https://www.nature.com/articles/s41418-017-0034-y

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics
Shao Thing Teoh, Martin Ogrodzinski, Christina Ross, Kent Hunter, and Sophia Lunt
https://www.frontiersin.org/articles/10.3389/fonc.2018.00174/full

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0179-2

PKM2 UNDER HYPOXIC ENVIRONMENT CAUSES RESISTANCE TO MTOR INHIBITOR IN HUMAN CASTRATION RESISTANT PROSTATE CANCER
Yota Yasumizu, Hiroshi Hongo, Takeo Kosaka, Shuji Mikami, Koshiro Nishimoto, Eiji Kikuchi, and Mototsugu Oya
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25498&path%5B%5D=79840

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Amino acid metabolism and urea cycle
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Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells
Chih‐Sheng Yang, Eleni Stampouloglou, Nathan M Kingston, Liye Zhang, Stefano Monti and Xaralabos Varelas
http://EMBOr.embopress.org/content/19/6/e43577?etoc

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity
Joshua D. Ochocki, Sanika Khare, Markus Hess, Daniel Ackerman, Bo Qiu, Jennie I. Daisak, Andrew J. Worth, Nan Lin, Pearl Lee, Hong Xie, Bo Li, Bradley Wubbenhorst, Tobi G. Maguire, Katherine L. Nathanson, James C. Alwine, Ian A. Blair, Itzhak Nissim, Brian Keith, M. Celeste Simon
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30252-3

Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer
Yaping Shao, Guozhu Ye, Shancheng Ren, Hai‐Long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun, Guowang Xu
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31313#

Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells
Stephanie Lucas, Guohua Chen, Siddhesh Aras, Jian Wang
http://www.life-science-alliance.org/content/1/2/e201800036

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Lipid metabolism
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De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer
Anju Singh, Christian Ruiz, Kavita Bhalla, John A. Haley, Qing Kay Li, George Acquaah-Mensah, Emily Montal, Kuladeep R. Sudini, Ferdinandos Skoulidis, Ignacio I. Wistuba, Vassiliki Papadimitrakopoulou, John V. Heymach, Laszlo G. Boros, Edward Gabrielson, Julian Carretero, Kwok-kin Wong, John D. Haley, Shyam Biswal, and Geoffrey D. Girnun
http://www.fasebj.org/doi/abs/10.1096/fj.201800204?ai=ts&ui=ly8&af=T

Preparation of Lipid-Stripped Serum for the Study of Lipid Metabolism in Cell Culture
Aaron M. Hosios, Zhaoqi Li, Evan C. Lien, Matthew G. Vander Heiden
https://bio-protocol.org/e2876

PPARγ is dispensable for clear cell renal cell carcinoma progression
Danielle J. Sanchez, David J. Steger, Nicolas Skuli, Ankita Bansal, M. Celeste Simon
https://www.molmetab.com/article/S2212-8778(18)30439-3/abstract

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
Hideki Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30312-7

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells
Katharina Leithner, Alexander Triebl, Martin Trötzmüller, Barbara Hinteregger, Petra Leko, Beatrix I. Wieser, Gabriele Grasmann, Alexandra L. Bertsch, Thomas Züllig, Elvira Stacher, Alessandro Valli, Ruth Prassl, Andrea Olschewski, Adrian L. Harris, Harald C. Köfeler, Horst Olschewski, and Andelko Hrzenjak
http://www.pnas.org/content/115/24/6225

Structural basis for regulation of human acetyl-CoA carboxylase
Moritz Hunkeler, Anna Hagmann, Edward Stuttfeld, Mohamed Chami, Yakir Guri, Henning Stahlberg & Timm Maier
https://www.nature.com/articles/s41586-018-0201-4

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Nucleotides and NAD
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Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30387-5

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides
Olivier Sallin, Luc Reymond, Corentin Gondrand, Fabio Raith, Birgit Koch, Kai Johnsson
https://elifesciences.org/articles/32638

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
D. Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Terttu Suormala, Seraina Lutz, Rod Chalk, Oktawia Borkowska, Matthias R. Baumgartner & Wyatt W. Yue
https://www.nature.com/articles/s41467-018-04735-2

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Mitochondria
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Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism
Julie Lavie, Harmony De Belvalet, Sessinou Sonon, Ana Madalina Ion, Elodie Dumon, Su Melser, Didier Lacombe, Jean-William Dupuy, Claude Lalou, Giovanni Bénard
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30746-0

MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis
Eunjin Koh, Young Kyung Kim, Daye Shin and Kyung-Sup Kim
http://www.biochemj.org/content/475/10/1687?etoc

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
Julian Hlouschek, Christine Hansel, Verena Jendrossek, and Johann Matschke
https://www.frontiersin.org/articles/10.3389/fonc.2018.00170/full

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Starvation
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PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells
Seong M. Kim, Tricia T. Nguyen, Archna Ravi, Peter Kubiniok, Brendan T. Finicle, Vaishali Jayashankar, Leonel Malacrida, Jue Hou, Jane Robertson, Dong Gao, Jonathan Chernoff, Michelle A. Digman, Eric O. Potma, Bruce J. Tromberg, Pierre Thibault and Aimee L. Edinger
http://cancerdiscovery.aacrjournals.org/content/8/7/866

Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation
Nan Zhang, Xin Yang, Fengjie Yuan, Luyao Zhang, Yanan Wang, Lina Wang, Zebin Mao, Jianyuan Luo, Hongquan Zhang, Wei-Guo Zhu, Ying Zhao
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30724-1

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations
Raphaela Fritsche-Guenther, Christin Zasada, Guido Mastrobuoni, Nadine Royla, Roman Rainer, Florian Roßner, Matthias Pietzke, Edda Klipp, Christine Sers & Stefan Kempa
https://www.nature.com/articles/s41598-018-27394-1

Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress
Florian A. Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann S. Gallot, Aurélie Docquier, Allan F. Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, Béatrice Chabi, Marc Francaux, François Casas, Damien Freyssenet, Jennifer Rieusset, Sophie Giorgetti-Peraldi, Gilles Carnac, Vincent Ollendorff, François B. Favier
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0525-4

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Nutrient sensing
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The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect
Mónica Rosas Lemus, Elodie Roussarie, Noureddine Hammad, Alexis Mougeolle, Stéphane Ransac, Razanne Issa, Jean-Pierre Mazat, Salvador Uribe-Carvajal, Michel Rigoulet and Anne Devin
http://www.jbc.org/content/early/2018/06/15/jbc.RA118.003672.abstract

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway
Minji Lee, Jong Hyun Kim, Ina Yoon, Chulho Lee, Mohammad Fallahi Sichani, Jong Soon Kang, Jeonghyun Kang, Min Guo, Kang Young Lee, Gyoonhee Han, Sunghoon Kim, and Jung Min Han
http://www.pnas.org/content/115/23/E5279

High Glucose Reduces Megalin-Mediated Albumin Endocytosis in Renal Proximal Tubule Cells through Protein Kinase B O-GlcNAcylation
Diogo de Barros Peruchetti, Rodrigo Pacheco Silva-Aguiar, Gabriela Marques Siqueira, Wagner Barbosa Dias and Celso Caruso-Neves
http://www.jbc.org/content/early/2018/06/05/jbc.RA117.001337.abstract

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
Meng Yuan, Iain W. McNae, Yiyuan Chen, Elizabeth A. Blackburn, Martin A. Wear, Paul A.M. Michels, Linda A. Fothergill-Gilmore, Ted Hupp and Malcolm D. Walkinshaw
http://www.biochemj.org/content/475/10/1821?etoc

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Hypoxia/angiogenesis
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Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth
Elisabetta Zulato, Francesco Ciccarese, Giorgia Nardo, Marica Pinazza, Valentina Agnusdei, Micol Silic-Benussi, Vincenzo Ciminale, and Stefano Indraccolo
https://www.frontiersin.org/articles/10.3389/fonc.2018.00195/full

Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis
Eloy Moreno Roig, Ala Yaromina, Ruud Houben, Arjan J Groot, Ludwig Dubois, and Marc Vooijs
https://www.frontiersin.org/articles/10.3389/fonc.2018.00224/full

Codon-specific translation reprogramming promotes resistance to targeted therapy
Francesca Rapino, Sylvain Delaunay, […]Pierre Close
https://www.nature.com/articles/s41586-018-0243-7

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IDH
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
Courtney D. DiNardo, Eytan M. Stein, Stéphane de Botton, Gail J. Roboz, Jessica K. Altman, Alice S. Mims, Ronan Swords, Robert H. Collins, Gabriel N. Mannis, Daniel A. Pollyea, Will Donnellan, Amir T. Fathi, Arnaud Pigneux, Harry P. Erba, Gabrielle T. Prince, Anthony S. Stein, Geoffrey L. Uy, James M. Foran, Elie Traer, Robert K. Stuart, Martha L. Arellano, James L. Slack, Mikkael A. Sekeres, Christophe Willekens, Sung Choe, Hongfang Wang, Vickie Zhang, Katharine E. Yen, Stephanie M. Kapsalis, Hua Yang, David Dai, Bin Fan, Meredith Goldwasser, Hua Liu, Sam Agresta, Bin Wu, Eyal C. Attar, Martin S. Tallman, Richard M. Stone, and Hagop M. Kantarjian
https://www.nejm.org/doi/full/10.1056/NEJMoa1716984

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
Andrew M. Intlekofer, Alan H. Shih, Bo Wang, Abbas Nazir, Ariën S. Rustenburg, Steven K. Albanese, Minal Patel, Christopher Famulare, Fabian M. Correa, Naofumi Takemoto, Vidushi Durani, Hui Liu, Justin Taylor, Noushin Farnoud, Elli Papaemmanuil, Justin R. Cross, Martin S. Tallman, Maria E. Arcila, Mikhail Roshal, Gregory A. Petsko, Bin Wu, Sung Choe, Zenon D. Konteatis, Scott A. Biller, John D. Chodera, Craig B. Thompson, Ross L. Levine & Eytan M. Stein
https://www.nature.com/articles/s41586-018-0251-7

IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
Mohammed Khurshed, Niels Aarnoudse, Renske Hulsbos, Vashendriya V. V. Hira, Hanneke W. M. van Laarhoven, Johanna W. Wilmink, Remco J.Molenaar, and Cornelis J. F. van Noorden
http://www.fasebj.org/doi/abs/10.1096/fj.201800547R?ai=ts&ui=ly8&af=T

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Metformin / phenformin
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Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR
Sónia R. Veiga, Xuemei Ge, Carol A. Mercer, María I. Hernández-Álvarez, Hala Elnakat Thomas, Javier Hernandez-Losa, Santiago Ramón y Cajal, Antonio Zorzano, George Thomas and Sara C. Kozma
http://clincancerres.aacrjournals.org/content/early/2018/06/14/1078-0432.CCR-18-0177

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
Elisabet Cuyàs, Sara Verdura, Laura Llorach‐Pares, Salvador Fernández‐Arroyo, Fedra Luciano‐Mateo, Noemí Cabré, Jan Stursa, Lukas Werner, Begoña Martin‐Castillo, Benoit Viollet, Jiri Neuzil, Jorge Joven, Alfons Nonell‐Canals, Melchor Sanchez‐Martinez, Javier A. Menendez
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12772

Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo
Shilpa Thakur, Brianna Daley, Kelli Gaskins, Vasyl V. Vasko, Myriem Boufraqech, Dhaval Patel, Carole Sourbier, Jeff Reece, Sheue-Yann Cheng, Electron Kebebew, Sunita Agarwal and Joanna Klubo-Gwiezdzinska
http://clincancerres.aacrjournals.org/content/early/2018/06/20/1078-0432.CCR-17-3167

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Miscellaneous
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Altered exocrine function can drive adipose wasting in early pancreatic cancer
Laura V. Danai, Ana Babic, Michael H. Rosenthal, Emily A. Dennstedt, Alexander Muir, Evan C. Lien, Jared R. Mayers, Karen Tai, Allison N. Lau, Paul Jones-Sali, Carla M. Prado, Gloria M. Petersen, Naoki Takahashi, Motokazu Sugimoto, Jen Jen Yeh, Nicole Lopez, Nabeel Bardeesy, Carlos Fernandez-del Castillo, Andrew S. Liss, Albert C. Koong, Justin Bui, Chen Yuan, Marisa W. Welch, Lauren K. Brais, Matthew H. Kulke, Courtney Dennis, Clary B. Clish, Brian M. Wolpin & Matthew G. Vander Heiden
https://www.nature.com/articles/s41586-018-0235-7

Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nrf2 Activation.
Li Y, Chao X, Yang L, Lu Q, Li T, Ding WX, Ni HM.
https://ajp.amjpathol.org/article/S0002-9440(18)30223-2/fulltext

Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation
Catharina Bartmann, Sudha R. Janaki Raman, Jessica Flöter, Almut Schulze, Katrin Bahlke, Jana Willingstorfer, Maria Strunz, Achim Wöckel, Rainer J. Klement, Michaela Kapp, Cholpon S. Djuzenova, Christoph Otto and Ulrike Kämmerer
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0180-9

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
Nobuaki Takahashi, Hsing-Yu Chen, Isaac S. Harris, Daniel G. Stover, Laura M. Selfors, Roderick T. Bronson, Thomas Deraedt, Karen Cichowski, Alana L. Welm, Yasuo Mori, Gordon B. Mills, Joan S. Brugge
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30183-1

TAp73 contributes to the oxidative stress response by regulating protein synthesis
Alberto Marini, Barak Rotblat, Thomas Sbarrato, Maria Victoria Niklison-Chirou, John R. P. Knight, Kate Dudek, Carolyn Jones, Martin Bushell, Richard A. Knight, Ivano Amelio, Anne E. Willis, and Gerry Melino
http://www.pnas.org/content/115/24/6219

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6
Brendan T. Finicle, Manuel U. Ramirez, Gang Liu, Elizabeth M. Selwan, Alison N. McCracken, Jingwen Yu, Yoosun Joo, Jannett Nguyen, Kevin Ou, Saurabh Ghosh Roy, Victor D. Mendoza, Dania Virginia Corrales and Aimee L. Edinger
http://jcs.biologists.org/content/131/12/jcs213314

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation
Mohsen Hosseini, Léa Dousset, Walid Mahfouf, Martin Serrano-Sanchez, Isabelle Redonnet-Vernhet, Samir Mesli, Zeinab Kasraian, Emilie Obre, Marc Bonneu, Stephane Claverol, Marija Vlaski, Zoran Ivanovic, Walid Rachidi, Thierry Douki, Alain Taieb, Anne-Karine Bouzier-Sore, Rodrigue Rossignol, Hamid Reza Rezvani
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30824-6

GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma
Weiruo Zhang, Gina Bouchard, Alice Yu, Majid Shafiq, Mehran Jamali, Joseph B. Shrager, Kelsey Ayers, Shaimaa Bakr, Andrew J. Gentles, Maximilian Diehn, Andrew Quon, Robert B. West, Viswam Nair, Matt van de Rijn, Sandy Napel and Sylvia K. Plevritis
http://cancerres.aacrjournals.org/content/78/13/3445

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Reviews
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Recent advances in cancer metabolism: a technological perspective
Yun Pyo Kang, Nathan P. Ward & Gina M. DeNicola
https://www.nature.com/articles/s12276-018-0027-z

The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate
Peng Wei, Katja K. Dove, Claire Bensard, John C. Schell, Jared Rutter
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30031-X

Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Patricia Boya, Patrice Codogno, Natalia Rodriguez-Muela
http://dev.biologists.org/content/145/4/dev146506

Cancer Stem Cell Metabolism and Potential Therapeutic Targets
Vusala Snyder, Tamika Reed-Newman, Levi Arnold, Sufi Thomas, and Shrikant Anant
https://www.frontiersin.org/articles/10.3389/fonc.2018.00203/full

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication
Ernestina M. De Francesco, Federica Sotgia and Michael P. Lisanti
http://www.biochemj.org/content/475/9/1611?etoc

Hypoxia-Inducible Factor 2-Dependent Pathways Driving Von Hippel–Lindau-Deficient Renal Cancer
Florinda Melendez Rodriguez, Olga Roche, Ricardo Sanchez-Prieto, and Julián Aragones Lopez
https://www.frontiersin.org/articles/10.3389/fonc.2018.00214/full

Hypoxic Signalling in Tumour Stroma
Anu Laitala, and Janine Erler
https://www.frontiersin.org/articles/10.3389/fonc.2018.00189/full

Nutrient sensing, growth and senescence
Bernadette Carroll and Viktor I. Korolchuk
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14400

The role of DNA‐PK in aging and energy metabolism
Jay H. Chung
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14410

Regulation of chromatin and gene expression by metabolic enzymes and metabolites
Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger & Zhimin Lu
https://www.nature.com/articles/s41580-018-0029-7

Metabolic Regulation of Transcription and Chromatin
Ronald C. Conaway
https://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-062917-012600
* Willis IM, Moir RD. 2018. Signaling to and from the RNA polymerase III transcription and processing machinery.
https://www.annualreviews.org/doi/10.1146/annurev-biochem-062917-012612
* Suganuma T, Workman JL. 2018. Chromatin and metabolism.
https://www.annualreviews.org/doi/10.1146/annurev-biochem-062917-012634

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Comments
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Obesity Protects Cancer from Drugs Targeting Blood Vessels
Yihai Cao
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30321-8

A lysosomal proton pump turns on when glucose runs out
Karlett J. Parra and Summer R. Hayek
http://www.jbc.org/content/293/23/9124.full

OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!
Christos Chinopoulos
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30317-6

ROS Promotes Cancer Cell Survival through Calcium Signaling
Colleen R. Reczek, Navdeep S. Chandel
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30224-1

Basis of dATP inhibition of RNRs
Brandon L. Greene, Daniel G. Nocera and JoAnne Stubbe
http://www.jbc.org/content/293/26/10413.abstract.html

Macropinocytosis Fuels Prostate Cancer
Cosimo Commisso and Jayanta Debnath
http://cancerdiscovery.aacrjournals.org/content/8/7/800

Companies Scaling Back IDO1 Inhibitor Trials
http://cancerdiscovery.aacrjournals.org/content/8/7/OF5

Lung Cancer – Targeting Glutaminase May Overcome Resistance to mTOR Inhibition
http://cancerdiscovery.aacrjournals.org/content/8/7/OF11

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