Warburg metabolism
Slow TCA flux and ATP production in primary solid tumours but not metastases – Caroline R. Bartman, Daniel R. Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S. R. Jankowski, Laith Samarah, Noel R. Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn Davidson, Martin Wühr, Matthew G. Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang and Joshua D. Rabinowitz. https://www.nature.com/articles/s41586-022-05661-6
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma – Zijian Yang, Cong Yan, Jiaqiang Ma, Panpan Peng, Xuelian Ren, Shangli Cai, Xia Shen, Yingcheng Wu, Shu Zhang, Xiaoying Wang, Shuangjian Qiu, Jian Zhou, Jia Fan, He Huang and Qiang Gao. https://www.nature.com/articles/s42255-022-00710-w
Amino acid metabolism
Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells – Xiangdong Wang, Huihui Xiang, Yujiro Toyoshima, Weidong Shen, Shunsuke Shichi, Hiroki Nakamoto, Saori Kimura, Ko Sugiyama, Shigenori Homma, Yohei Miyagi, Akinobu Taketomi and Hidemitsu Kitamura. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-022-00301-z
Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis – Jingru Bai, Tong Liu, Bo Tu, Meng Yuan, Zhaoqi Shu, Minghe Fan, Sihan Huo, Yuyao Guo, Lina Wang, Hua Wang and Ying Zhao. https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2093026
Lipid metabolism
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling – Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M. Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H. Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V. Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimiliano Mazzone, Sara Zanivan, Jan Cools, Hans Wildiers, Véronique Baud, Thomas G. P. Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi and Sarah-Maria Fendt. https://www.nature.com/articles/s43018-023-00513-2
Stearate‐derived very long‐chain fatty acids are indispensable to tumor growth – Qiaoyun Chu, Ping Liu, Yihan Song, Ronghui Yang, Jing An, Xuewei Zhai, Jing Niu, Chuanzhen Yang, Binghui Li. https://www.embopress.org/doi/abs/10.15252/embj.2022111268
Mitochondria and TCA
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials – Timothy A. Yap, Naval Daver, Mikhila Mahendra, Jixiang Zhang, Carlos Kamiya-Matsuoka, Funda Meric-Bernstam, Hagop M. Kantarjian, Farhad Ravandi, Meghan E. Collins, Maria Emilia Di Francesco, Ecaterina E. Dumbrava, Siqing Fu, Sisi Gao, Jason P. Gay, Sonal Gera, Jing Han, David S. Hong, Elias J. Jabbour, Zhenlin Ju, Daniel D. Karp, Alessia Lodi, Jennifer R. Molina, Natalia Baran, Aung Naing, Maro Ohanian, Shubham Pant, Naveen Pemmaraju, Prithviraj Bose, Sarina A. Piha-Paul, Jordi Rodon, Carolina Salguero, Koji Sasaki, Anand K. Singh, Vivek Subbiah, Apostolia M. Tsimberidou, Quanyun A. Xu, Musa Yilmaz, Qi Zhang, Yuan Li, Christopher A. Bristow, Meenakshi B. Bhattacharjee, Stefano Tiziani, Timothy P. Heffernan, Christopher P. Vellano, Philip Jones, Cobi J. Heijnen, Annemieke Kavelaars, Joseph R. Marszalek and Marina Konopleva. https://www.nature.com/articles/s41591-022-02103-8
Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation – Joo Kyung Noh, Seon Rang Woo, Moonkyoo Kong, Min Kyeong Lee, Jung Woo Lee, Young Chan Lee, Seong-Gyu Ko, Young-Gyu Eun. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13328
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides – Hannah R. Bridges, James N. Blaza, Zhan Yin, Injae Chung, Michael N. Pollak, Judy Hirst. https://www.science.org/doi/abs/10.1126/science.ade3332
Starvation
The antitumour effects of caloric restriction are mediated by the gut microbiome – Yu-Qin Mao, Jia-Ting Huang, Shi-Long Zhang, Chao Kong, Zhan-Ming Li, Hui Jing, Hui-Ling Chen, Chao-Yue Kong, Sheng-Hui Huang, Pei-Ran Cai, Bing Han and Li-Shun Wang. https://www.nature.com/articles/s42255-022-00716-4
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress – Thao Thi Dang, Mi-Jeong Kim, Yoon Young Lee, Hien Thi Le, Kook Hwan Kim, Somi Nam, Seung Hwa Hyun, Hong Lim Kim, Su Wol Chung, Hun Taeg Chung, Eek-Hoon Jho, Hiderou Yoshida, Kyoungmi Kim, Chan Young Park, Myung-Shik Lee and Sung Hoon Back. https://www.tandfonline.com/doi/abs/10.1080/15548627.2023.2173900
mTOR
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation – Xiaoming Dai, Cong Jiang, Qiwei Jiang, Lan Fang, Haihong Yu, Jinhe Guo, Peiqiang Yan, Fangtao Chi, Tao Zhang, Hiroyuki Inuzuka, John M. Asara, Ping Wang, Jianping Guo and Wenyi Wei. https://www.nature.com/articles/s42255-022-00732-4
Ring domains are essential for GATOR2-dependent mTORC1 activation – Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01134-0
Dynamic metabolome profiling uncovers potential TOR signaling genes – Stella Reichling, Peter F Doubleday, Tomas Germade, Ariane Bergmann, Robbie Loewith, Uwe Sauer, Duncan Holbrook-Smith. https://elifesciences.org/articles/84295
IDH
Natural and Synthetic 2-Oxogluturate Derivatives are Substrates for Oncogenic Variants of Human Isocitrate Dehydrogenase 1 and 2 – Xiao Liu, Raphael Reinbold, Shuang Liu, Ryan A. Herold, Patrick Rabe, Stéphanie Duclos, Rahul B. Yadav, Martine I. Abboud, Sandrine Thieffine, Fraser A. Armstrong, Lennart Brewitz, Christopher J. Schofield. https://www.jbc.org/article/S0021-9258(23)00005-4/fulltext
Cancer Immunometabolism
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis – Stefanie K. Wculek, Ignacio Heras-Murillo, Annalaura Mastrangelo, Diego Mañanes, Miguel Galán, Verónica Miguel, Andrea Curtabbi, Coral Barbas, Navdeep S. Chandel, José Antonio Enríquez, Santiago Lamas, David Sancho. https://www.cell.com/immunity/pdfExtended/S1074-7613(23)00021-3
Miscellaneous
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan – Clara Correia-Melo, Stephan Kamrad, Roland Tengölics, Christoph B. Messner, Pauline Trebulle, StJohn Townsend, Sreejith Jayasree Varma, Anja Freiwald, Benjamin M. Heineike, Kate Campbell, Lucía Herrera-Dominguez, Simran Kaur Aulakh, Lukasz Szyrwiel, Jason S.L. Yu, Aleksej Zelezniak, Vadim Demichev, Michael Mülleder, Balázs Papp, Mohammad Tauqeer Alam, Markus Ralser. https://www.cell.com/cell/fulltext/S0092-8674(22)01520-3
Metabolic profiling reveals metabolic features of consolidation therapy in pediatric acute lymphoblastic leukemia – Jinqiu Fu, Aijun Zhang, Qinqin Liu, Dong Li, Xiaoming Wang and Libo Si. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-023-00302-6
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy – Michal K. Handzlik, Jivani M. Gengatharan, Katie E. Frizzi, Grace H. McGregor, Cameron Martino, Gibraan Rahman, Antonio Gonzalez, Ana M. Moreno, Courtney R. Green, Lucie S. Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis J. Fallon, Amandine Chaix, Satchidananda Panda, Prashant Mali, Martina Wallace, Rob Knight, Marin L. Gantner, Nigel A. Calcutt and Christian M. Metallo. https://www.nature.com/articles/s41586-022-05637-6
Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice – Flavia A. Graca, Anna Stephan, Yong-Dong Wang, Abbas Shirinifard, Jianqin Jiao, Peter Vogel, Myriam Labelle, Fabio Demontis. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01835-6
Reviews
Metabolites as signalling molecules – Steven Andrew Baker & Jared Rutter. https://www.nature.com/articles/s41580-022-00572-w
Diverse effects of obesity on antitumor immunity and immunotherapy – Lydia Dyck, Lydia Lynch. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(22)00294-5
Comments
Time to hit pause on mitochondria-targeting cancer therapies – Xue Zhang & Chi V. Dang. https://www.nature.com/articles/s41591-022-02129-y
AMPK knocks at the gate of GATOR – Nerea Deleyto-Seldas & Alejo Efeyan. https://www.nature.com/articles/s42255-022-00729-z
GATOR2 rings GATOR1 to speak to mTORC1 – Umakant Sahu, Issam Ben-Sahra. https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01168-6
Thrifty energy metabolism in solid tumours – https://www.nature.com/articles/d41586-023-00151-9
Metabolism and Cancer articles 