Nucleotides
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle – Jong Shin, Hannan Mir, Maaz A. Khurram, Kenji M. Fujihara, Brian D. Dynlacht, Timothy J. Cardozo and Richard Possemato. https://www.nature.com/articles/s42255-023-00735-9
Nucleotide metabolism is linked to cysteine availability during ferroptosis – Annamarie E. Allen, Yudong Sun, Fangchao Wei, Michael A. Reid, Jason W. Locasale. https://www.jbc.org/article/S0021-9258(23)00171-0
p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression – Jianhong Zhao, Xiaojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang, Nagarajan Elumalai, Chenhui Tian, Jinmiao Zhang, Yanliang Liu, Zhiqiang Chen, Xinyi Zhou, Mingzhi Wu, Mengjiao Li, Edward V. Prochownik, Ali Tavassoli, Congqing Jiang and Youjun Li. https://www.nature.com/articles/s41419-023-05625-
NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis – Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes. https://www.sciencedirect.com/science/article/pii/S2213231723000289
Mitochondria / Hypoxia
Mitochondrial respiration reduces exposure of the nucleus to oxygen – Mateus Prates Mori, Rozhin Penjweini, Jin Ma, Greg Alspaugh, Alessio Andreoni, Young-Chae Kim, Ping-Yuan Wang, Jay R. Knutson, Paul M. Hwang. https://www.jbc.org/article/S0021-9258(23)00150-3
Long noncoding RNA GATA2-AS1 augments endothelial Hypoxia Inducible Factor 1-α induction and regulates hypoxic signaling – H.S. Jeffrey Man, Noeline Subramaniam, Tiana Downs, Aravin N. Sukumar, Aninda D. Saha, Ranju Nair, Lucy Chen, Daniel Teitelbaum, Paul J. Turgeon, Kyung Ha Ku, Eileen Tran, Marc de Perrot, Philip A. Marsden. https://www.jbc.org/article/S0021-9258(23)00161-8
Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress – Ying Liu, Kejia Liu, Rick F. Thorne, Ronghua Shi, Qingyuan Zhang, Mian Wu, Lianxin Liu. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00052-9
Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma – Haowen Jiang, Rachel Greathouse, Sarah J. Tiche, Man Zhao, Bo He, Yang Li, Albert M. Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-Ning Zhou, Joshua J. Gruber, Erinn B. Rankin, Zhen Hu, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye. https://aacrjournals.org/cancerres/article/83/2/181/715072
Amino acid / Glucose metabolism
Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer – Seung Joon Park, Hee Chan Yoo, Eunyong Ahn, Enzhi Luo, Yeabeen Kim, Yulseung Sung, Ya Chun Yu, Kibum Kim, Do Sik Min, Hee Seung Lee, Geum-Sook Hwang, TaeJin Ahn, Junjeong Choi, Seungmin Bang, Jung Min Han. https://aacrjournals.org/cancerres/article-abstract/83/5/735/716680
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma – Kui Wang, Li Luo, Shuyue Fu, Mao Wang, Zihao Wang, Lixia Dong, Xingyun Wu, Lunzhi Dai, Yong Peng, Guobo Shen, Hai-Ning Chen, Edouard Collins Nice, Xiawei Wei and Canhua Huang. https://www.nature.com/articles/s41467-023-36708-5
Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells – Asmaa El-Kenawi, Anders Berglund, Veronica Estrella, Yonghong Zhang, Min Liu, Ryan M. Putney, Sean J. Yoder, Joseph Johnson, Joel Brown, Robert Gatenby. https://aacrjournals.org/cancerres/article/83/5/720/716681
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells – Mika B. Jekabsons, Mollie Merrell, Anna G. Skubiz, Noah Thornton, Sandra Milasta, Douglas Green, Taosheng Chen, Yan-Hong Wang, Bharathi Avula, Ikhlas A. Khan and Yu-Dong Zhou. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-023-00303-5
Starvation / mTOR
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies – Yu Zhang, Chengzhong Lin, Zheqi Liu, Yiting Sun, Mingtao Chen Yibo Guo, Wei Liu, Chenping Zhang, Wantao Chen, Jian Sun, Ronghui Xia, Yuhua Hu, Xi Yang, Jiang Li, Zhiyuan Zhang, Wei Cao, Shuyang Sun, Xu Wang, Tong Ji. https://www.sciencedirect.com/science/article/pii/S1550413122004909
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation – Marco Caligaris, Raffaele Nicastro Is a corresponding author, Zehan Hu, Farida Tripodi, Johannes Erwin Hummel, Benjamin Pillet, Marie-Anne Deprez, Joris Winderickx, Sabine Rospert, Paola Coccetti, Jörn Dengjel, Claudio De Virgilio. https://elifesciences.org/articles/84319
Monitoring the 5′UTR landscape reveals isoform switches to drive translational efficiencies in cancer – Ramona Weber, Umesh Ghoshdastider, Daniel Spies, Clara Duré, Fabiola Valdivia-Francia, Merima Forny, Mark Ormiston, Peter F. Renz, David Taborsky, Merve Yigit, Martino Bernasconi, Homare Yamahachi and Ataman Sendoel. https://www.nature.com/articles/s41388-022-02578-2
TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling – Chun-Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peeper. https://www.embopress.org/doi/abs/10.15252/embj.2022111614
IDH / Lipids
Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability – Daniel Thomas, Manhong Wu, Yusuke Nakauchi, Ming Zheng, Chloe A.L. Thompson-Peach, Kelly Lim, Niklas Landberg, Thomas Köhnke, Nirmal Robinson, Satinder Kaur, Monika Kutyna, Melissa Stafford, Devendra Hiwase, Andreas Reinisch, Gary Peltz, Ravindra Majeti. https://aacrjournals.org/cancerdiscovery/article/13/2/496/716313
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer – Keisuke Shigeta, Masanori Hasegawa, Takako Hishiki, Yoshiko Naito, Yuto Baba, Shuji Mikami, Kazuhiro Matsumoto, Ryuichi Mizuno, Akira Miyajima, Eiji Kikuchi, Hideyuki Saya, Takeo Kosaka, Mototsugu Oya. https://www.embopress.org/doi/full/10.15252/embj.2022110620
Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis – Joseph Puccini, Jia Wei, Liang Tong and Dafna Bar-Sagi. https://www.pnas.org/doi/10.1073/pnas.2213272120
Cancer Immunometabolism
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness – Hongcheng Cheng, Yajing Qiu, Yue Xu, Li Chen, Kaili Ma, Mengyuan Tao, Luke Frankiw, Hongli Yin, Ermei Xie, Xiaoli Pan, Jing Du, Zhe Wang, Wenjie Zhu, Lu Chen, Lianjun Zhang and Guideng Li. https://www.nature.com/articles/s42255-022-00730-6
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments – Ya-Ting Wang, Alissa J. Trzeciak, Waleska Saitz Rojas, Pedro Saavedra, Yan-Ting Chen, Rachel Chirayil, Jon Iker Etchegaray, Christopher D. Lucas, Daniel J. Puleston, Kayvan R. Keshari, Justin S.A. Perry. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00542-3
Miscellaneous
Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production – Francesca Romana Pellegrini, Sara De Martino, Giulia Fianco, Irene Ventura, Davide Valente, Mario Fiore, Daniela Trisciuoglio and Francesca Degrassi. https://www.tandfonline.com/doi/full/10.1080/15548627.2023.2170962
CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors – Haojian Li, Yue Liu, Yunjie Xiao, Crystal N. Wilson, Hui Jen Bai, Maxwell D. Jones, Shihchun Wang, Jennie E. DeVore, Esther Y. Maier, Stephen T. Durant, Myriem Boufraqech and Urbain Weyemi. https://www.pnas.org/doi/10.1073/pnas.2212072120
Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle – Vakil Takhaveev, Serdar Özsezen, Edward N. Smith, Andre Zylstra, Marten L. Chaillet, Haoqi Chen, Alexandros Papagiannakis, Andreas Milias-Argeitis and Matthias Heinemann. https://www.nature.com/articles/s42255-023-00741-x
Reviews
Acetyl-CoA metabolism in cancer – David A. Guertin and Kathryn E. Wellen. https://www.nature.com/articles/s41568-022-00543-5
Metabolism and epigenetics at the heart of T cell function – Leticia Soriano-Baguet, Dirk Brenner. https://www.cell.com/trends/immunology/fulltext/S1471-4906(23)00002-9
Control of immune cell function by the unfolded protein response – Giusy Di Conza, Ping-Chih Ho, Juan R. Cubillos-Ruiz and Stanley Ching-Cheng Huang. https://www.nature.com/articles/s41577-023-00838-0
The magic bullet: Niclosamide – Haowen Jiang, Albert M. Li, Jiangbin Ye. https://www.frontiersin.org/articles/10.3389/fonc.2022.1004978/full
Fasting and fasting mimicking diets in cancer prevention and therapy – Olga Blaževitš, Maira Di Tano, Valter D. Longo. https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00268-0
Unfolded protein response and angiogenesis in malignancies – Amin Izadpanah, Kurtis Willingham, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah. https://www.sciencedirect.com/science/article/abs/pii/S0304419X22001640
Effect of metabolism on the immune microenvironment of breast cancer – Yingming Zhou, Hu Wang, Yi Luo, Biguang Tuo, Xuemei Liu, Taolang Li. https://www.sciencedirect.com/science/article/pii/S0304419X23000100
Nutrient transporters: connecting cancer metabolism to therapeutic opportunities – Zeribe Chike Nwosu, Mun Gu Song, Marina Pasca di Magliano, Costas A. Lyssiotis and Sung Eun Kim. https://www.nature.com/articles/s41388-023-02593-x
Comments
Fatty acids prime the lung as a site for tumour spread – Laura V. Pinheiro, Kathryn E. Wellen. https://www.nature.com/articles/d41586-023-00538-8
Oncogenic IDH1 Mutation Imparts Therapeutically Targetable Metabolic Dysfunction in Multiple Tumor Types – Troy M. Robinson, Ross L. Levine. https://aacrjournals.org/cancerdiscovery/article-abstract/13/2/266/716305
Metabolism and Cancer articles 